@article{ThiemBagheriGrosseSiestrupetal.2016,
  author    = {Thiem, A. and Bagheri, M. and Grosse-Siestrup, C. and Zehbe, Rolf},
  title     = {Gelatin-poly(lactic-co-glycolic acid) scaffolds with oriented pore channel architecture - From in vitro to in vivo testing},
  series = {Vision research : an international journal for functional aspects of vision.},
  volume    = {62},
  journal   = {Vision research : an international journal for functional aspects of vision.},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0928-4931},
  doi       = {10.1016/j.msec.2016.02.019},
  pages     = {585 -- 595},
  year      = {2016},
  abstract  = {A gelatin-poly(lactic-co-glycolic acid), PLGA, composite scaffold, featuring a highly oriented pore channel structure, was developed as a template for articular cartilage regeneration. As a design principle the composite scaffold was optimized to contain only medical grade educts and accordingly no chemical cross linking agents or other toxicological relevant substances or methods were used. Scaffolds were synthesized using a freeze structuring method combined with an electrochemical process followed by freeze-drying. Finally, cross linking was performed using dehydrothermal treatment, which was simultaneously used for sterilization purposes. These composite scaffolds were analyzed in regard to structural and biomechanical properties, and to their degradation behavior. Furthermore, cell culture performance was tested using chondrocytes originated from joint articular cartilage tissue from 6 to 10 months old domestic pigs. Finally, the scaffolds were tested for tissue biocompatibility and their ability for tissue integration in a rat model. The scaffolds showed both excellent functional performance and high biocompatibility in vitro and in vivo. We expect that these gelatin-PLGA scaffolds can effectively support chondrogenesis in vivo demonstrating great potential for the use in cartilage defect treatment. (C) 2016 Elsevier B.V. All rights reserved.},
  language  = {en}
}
@article{ZehbeZaslanskyMochalesetal.2016,
  author    = {Zehbe, Rolf and Zaslansky, Paul and Mochales, Carolina and Mueller, Wolf-Dieter and Fleck, Claudia},
  title     = {Synchrotron micro tomographic evaluation of multilayered zirconia ceramics-Volumetric effects after indentation},
  series = {Journal of the European Ceramic Society},
  volume    = {36},
  journal   = {Journal of the European Ceramic Society},
  publisher = {Elsevier},
  address   = {Oxford},
  issn      = {0955-2219},
  doi       = {10.1016/j.jeurceramsoc.2015.09.015},
  pages     = {171 -- 177},
  year      = {2016},
  abstract  = {Electrophoretic deposition was used to produce zirconia specimen consisting of alternating layers of fully stabilized cubic zirconia and partially stabilized tetragonal zirconia. In this configuration, the tetragonal stabilized zirconia layers can undergo transformation toughening upon mechanical induced stresses, while the cubic stabilized layers can act as confining element. To understand the volumetric changes due to transformation toughening in these layered materials after indentation, we used an advanced synchrotron-based X-ray mu CT setup and compared the results with surface sensitive methods like Raman spectroscopy, AFM and white light interferometry. The high spatial resolution and the adapted beam energy between the absorption edges of zirconia and yttria allowed discriminating between individual layers due to differences in their yttria content. Furthermore we were able to identify single indents and link volume changes to different physical effects in the different stabilized zirconia parts and visualize the three dimensional volume around only few micrometre sized indents. (C) 2015 Elsevier Ltd. All rights reserved.},
  language  = {en}
}
@article{ZehbeZehbe2016,
  author    = {Zehbe, Rolf and Zehbe, Kerstin},
  title     = {Strontium doped poly-epsilon-caprolactone composite scaffolds made by reactive foaming},
  series = {The European journal of the history of economic thought},
  volume    = {67},
  journal   = {The European journal of the history of economic thought},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0928-4931},
  doi       = {10.1016/j.msec.2016.05.045},
  pages     = {259 -- 266},
  year      = {2016},
  abstract  = {In the reconstruction and regeneration of bone tissue, a primary goal is to initiate bone growth and to stabilize the surrounding bone. In this regard, a potentially useful component in biomaterials for bone tissue engineering is strontium, which acts as cationic active agent, triggering certain intracellular pathways and acting as so called dual action bone agent which inhibits bone resorption while stimulating bone regeneration. In this study we established a novel processing for the foaming of a polymer (poly-epsilon-caprolactone) and simultaneous chemical reaction of a mixture of calcium and strontium hydroxides to the respective carbonates using supercritical carbon dioxide. The resultant porous composite scaffold was optimized in composition and strontium content and was characterized via different spectroscopic (infrared and Raman spectroscopy, energy dispersive X-ray spectroscopy), imaging (SEM, mu CT), mechanical testing and in vitro methods (fluorescence vital staining, MTT-assay). As a result, the composite scaffold showed good in vitro biocompatibility with partly open pore structure and the expected chemistry. First mechanical testing results indicate sufficient mechanical stability to support future in vivo applications. (C) 2016 Elsevier B.V. All rights reserved.},
  language  = {en}
}
@article{ZehbeMochalesRadziketal.2016,
  author    = {Zehbe, Rolf and Mochales, Carolina and Radzik, Daniela and Mueller, Wolf-Dieter and Fleck, Claudia},
  title     = {Electrophoretic deposition of multilayered (cubic and tetragonal stabilized) zirconia ceramics for adapted crack deflection},
  series = {Journal of the European Ceramic Society},
  volume    = {36},
  journal   = {Journal of the European Ceramic Society},
  publisher = {Elsevier},
  address   = {Oxford},
  issn      = {0955-2219},
  doi       = {10.1016/j.jeurceramsoc.2015.08.022},
  pages     = {357 -- 364},
  year      = {2016},
  abstract  = {The electrophoretic deposition process was used to produce multi-layered ceramics consisting of alternating layers of fully stabilized cubic zirconia and partially stabilized tetragonal zirconia to make use of their different mechanical behaviour, investigating the possibility to deflect advancing cracks at the interfaces of the different layers. This crack deflection is apparently impacted by a toughening mechanism only found in the tetragonal stabilized zirconia polymorph and is characterized by the stress induced transformation of the metastable tetragonal phase into the monoclinic one, which is accompanied by a volume increase resulting in a closing mechanism for advancing cracks. While improving the electrophoretic deposition process, we investigated the transformation toughening mechanism at the layer interfaces and their effect on crack propagation. Investigations involved a combination of different imaging methods, including light microscopy, white light interferometry, atomic force microscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy and Raman spectroscopy. (C) 2015 Elsevier Ltd. All rights reserved.},
  language  = {en}
}