@article{MaaresKeilKozaetal.2018, author = {Maares, Maria and Keil, Claudia and Koza, Jenny and Straubing, Sophia and Schwerdtle, Tanja and Haase, Hajo}, title = {In Vitro Studies on Zinc Binding and Buffering by Intestinal Mucins}, series = {International Journal of Molecular Sciences}, volume = {19}, journal = {International Journal of Molecular Sciences}, number = {9}, issn = {1422-0067}, doi = {10.3390/ijms19092662}, pages = {20}, year = {2018}, abstract = {The investigation of luminal factors influencing zinc availability and accessibility in the intestine is of great interest when analyzing parameters regulating intestinal zinc resorption. Of note, intestinal mucins were suggested to play a beneficial role in the luminal availability of zinc. Their exact zinc binding properties, however, remain unknown and the impact of these glycoproteins on human intestinal zinc resorption has not been investigated in detail. Thus, the aim of this study is to elucidate the impact of intestinal mucins on luminal uptake of zinc into enterocytes and its transfer into the blood. In the present study, in vitro zinc binding properties of mucins were analyzed using commercially available porcine mucins and secreted mucins of the goblet cell line HT-29-MTX. The molecular zinc binding capacity and average zinc binding affinity of these glycoproteins demonstrates that mucins contain multiple zinc-binding sites with biologically relevant affinity within one mucin molecule. Zinc uptake into the enterocyte cell line Caco-2 was impaired by zinc-depleted mucins. Yet this does not represent their form in the intestinal lumen in vivo under zinc adequate conditions. In fact, zinc-uptake studies into enterocytes in the presence of mucins with differing degree of zinc saturation revealed zinc buffering by these glycoproteins, indicating that mucin-bound zinc is still available for the cells. Finally, the impact of mucins on zinc resorption using three-dimensional cultures was studied comparing the zinc transfer of a Caco-2/HT-29-MTX co-culture and conventional Caco-2 monoculture. Here, the mucin secreting co-cultures yielded higher fractional zinc resorption and elevated zinc transport rates, suggesting that intestinal mucins facilitate the zinc uptake into enterocytes and act as a zinc delivery system for the intestinal epithelium.}, language = {en} } @article{NitzeGrosseJonesetal.2018, author = {Nitze, Ingmar and Grosse, Guido and Jones, Benjamin M. and Romanovsky, Vladimir E. and Boike, Julia}, title = {Remote sensing quantifies widespread abundance of permafrost region disturbances across the Arctic and Subarctic}, series = {Nature Communications}, volume = {9}, journal = {Nature Communications}, publisher = {Nature Publ. Group}, address = {London}, issn = {2041-1723}, doi = {10.1038/s41467-018-07663-3}, pages = {11}, year = {2018}, abstract = {Local observations indicate that climate change and shifting disturbance regimes are causing permafrost degradation. However, the occurrence and distribution of permafrost region disturbances (PRDs) remain poorly resolved across the Arctic and Subarctic. Here we quantify the abundance and distribution of three primary PRDs using time-series analysis of 30-m resolution Landsat imagery from 1999 to 2014. Our dataset spans four continental-scale transects in North America and Eurasia, covering similar to 10\% of the permafrost region. Lake area loss (-1.45\%) dominated the study domain with enhanced losses occurring at the boundary between discontinuous and continuous permafrost regions. Fires were the most extensive PRD across boreal regions (6.59\%), but in tundra regions (0.63\%) limited to Alaska. Retrogressive thaw slumps were abundant but highly localized (< 10(-5)\%). Our analysis synergizes the global-scale importance of PRDs. The findings highlight the need to include PRDs in next-generation land surface models to project the permafrost carbon feedback.}, language = {en} } @article{KathBoitGuilletal.2018, author = {Kath, Nadja J. and Boit, Alice and Guill, Christian and Gaedke, Ursula}, title = {Accounting for activity respiration results in realistic trophic transfer efficiencies in allometric trophic network (ATN) models}, series = {Theoretical ecology}, volume = {11}, journal = {Theoretical ecology}, number = {4}, publisher = {Springer}, address = {Heidelberg}, issn = {1874-1738}, doi = {10.1007/s12080-018-0378-z}, pages = {453 -- 463}, year = {2018}, abstract = {Allometric trophic network (ATN) models offer high flexibility and scalability while minimizing the number of parameters and have been successfully applied to investigate complex food web dynamics and their influence on food web diversity and stability. However, the realism of ATN model energetics has never been assessed in detail, despite their critical influence on dynamic biomass and production patterns. Here, we compare the energetics of the currently established original ATN model, considering only biomass-dependent basal respiration, to an extended ATN model version, considering both basal and assimilation-dependent activity respiration. The latter is crucial in particular for unicellular and invertebrate organisms which dominate the metabolism of pelagic and soil food webs. Based on metabolic scaling laws, we show that the extended ATN version reflects the energy transfer through a chain of four trophic levels of unicellular and invertebrate organisms more realistically than the original ATN version. Depending on the strength of top-down control, the original ATN model yields trophic transfer efficiencies up to 71\% at either the third or the fourth trophic level, which considerably exceeds any realistic values. In contrast, the extended ATN version yields realistic trophic transfer efficiencies 30\% at all trophic levels, in accordance with both physiological considerations and empirical evidence from pelagic systems. Our results imply that accounting for activity respiration is essential for consistently implementing the metabolic theory of ecology in ATN models and for improving their quantitative predictions, which makes them more powerful tools for investigating the dynamics of complex natural communities.}, language = {en} } @misc{FritzRosaSicard2018, author = {Fritz, Michael Andre and Rosa, Stefanie and Sicard, Adrien}, title = {Mechanisms Underlying the Environmentally Induced Plasticity of Leaf Morphology}, series = {Frontiers in genetics}, volume = {9}, journal = {Frontiers in genetics}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-8021}, doi = {10.3389/fgene.2018.00478}, pages = {25}, year = {2018}, abstract = {The primary function of leaves is to provide an interface between plants and their environment for gas exchange, light exposure and thermoregulation. Leaves have, therefore a central contribution to plant fitness by allowing an efficient absorption of sunlight energy through photosynthesis to ensure an optimal growth. Their final geometry will result from a balance between the need to maximize energy uptake while minimizing the damage caused by environmental stresses. This intimate relationship between leaf and its surroundings has led to an enormous diversification in leaf forms. Leaf shape varies between species, populations, individuals or even within identical genotypes when those are subjected to different environmental conditions. For instance, the extent of leaf margin dissection has, for long, been found to inversely correlate with the mean annual temperature, such that Paleobotanists have used models based on leaf shape to predict the paleoclimate from fossil flora. Leaf growth is not only dependent on temperature but is also regulated by many other environmental factors such as light quality and intensity or ambient humidity. This raises the question of how the different signals can be integrated at the molecular level and converted into clear developmental decisions. Several recent studies have started to shed the light on the molecular mechanisms that connect the environmental sensing with organ-growth and patterning. In this review, we discuss the current knowledge on the influence of different environmental signals on leaf size and shape, their integration as well as their importance for plant adaptation.}, language = {en} } @article{WaltherGuanterHeimetal.2018, author = {Walther, Sophia and Guanter, Luis and Heim, Birgit and Jung, Martin and Duveiller, Gregory and Wolanin, Aleksandra and Sachs, Torsten}, title = {Assessing the dynamics of vegetation productivity in circumpolar regions with different satellite indicators of greenness and photosynthesis}, series = {Biogeosciences}, volume = {15}, journal = {Biogeosciences}, number = {20}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1726-4170}, doi = {10.5194/bg-15-6221-2018}, pages = {6221 -- 6256}, year = {2018}, abstract = {High-latitude treeless ecosystems represent spatially highly heterogeneous landscapes with small net carbon fluxes and a short growing season. Reliable observations and process understanding are critical for projections of the carbon balance of the climate-sensitive tundra. Space-borne remote sensing is the only tool to obtain spatially continuous and temporally resolved information on vegetation greenness and activity in remote circumpolar areas. However, confounding effects from persistent clouds, low sun elevation angles, numerous lakes, widespread surface inundation, and the sparseness of the vegetation render it highly challenging. Here, we conduct an extensive analysis of the timing of peak vegetation productivity as shown by satellite observations of complementary indicators of plant greenness and photosynthesis. We choose to focus on productivity during the peak of the growing season, as it importantly affects the total annual carbon uptake. The suite of indicators are as follows: (1) MODIS-based vegetation indices (VIs) as proxies for the fraction of incident photosynthetically active radiation (PAR) that is absorbed (fPAR), (2) VIs combined with estimates of PAR as a proxy of the total absorbed radiation (APAR), (3) sun-induced chlorophyll fluorescence (SIF) serving as a proxy for photosynthesis, (4) vegetation optical depth (VOD), indicative of total water content and (5) empirically upscaled modelled gross primary productivity (GPP). Averaged over the pan-Arctic we find a clear order of the annual peak as APAR <= GPP < SIF < VIs/VOD. SIF as an indicator of photosynthesis is maximised around the time of highest annual temperatures. The modelled GPP peaks at a similar time to APAR. The time lag of the annual peak between APAR and instantaneous SIF fluxes indicates that the SIF data do contain information on light-use efficiency of tundra vegetation, but further detailed studies are necessary to verify this. Delayed peak greenness compared to peak photosynthesis is consistently found across years and land-cover classes. A particularly late peak of the normalised difference vegetation index (NDVI) in regions with very small seasonality in greenness and a high amount of lakes probably originates from artefacts. Given the very short growing season in circumpolar areas, the average time difference in maximum annual photosynthetic activity and greenness or growth of 3 to 25 days (depending on the data sets chosen) is important and needs to be considered when using satellite observations as drivers in vegetation models.}, language = {en} } @article{SchaalRutlohWeidenfeldetal.2018, author = {Schaal, Frederik and Rutloh, Michael and Weidenfeld, Susanne and Stumpe, Joachim and Michler, Peter and Pruss, Christof and Osten, Wolfgang}, title = {Optically addressed modulator for tunable spatial polarization control}, series = {Optics express : the international electronic journal of optics}, volume = {26}, journal = {Optics express : the international electronic journal of optics}, number = {21}, publisher = {Optical Society of America}, address = {Washington}, issn = {1094-4087}, doi = {10.1364/OE.26.028119}, pages = {28119 -- 28130}, year = {2018}, abstract = {We present an optically addressed non-pixelated spatial light modulator. The system is based on reversible photoalignment of a LC cell using a red light sensitive novel azobenzene photoalignment layer. It is an electrode-free device that manipulates the liquid crystal orientation and consequently the polarization via light without artifacts caused by electrodes. The capability to miniaturize the spatial light modulator allows the integration into a microscope objective. This includes a miniaturized 200 channel optical addressing system based on a VCSEL array and hybrid refractive-diffractive beam shapers. As an application example, the utilization as a microscope objective integrated analog phase contrast modulator is shown. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement}, language = {en} } @article{PengLiuWangetal.2018, author = {Peng, Junjie and Liu, Danxu and Wang, Yingtao and Zeng, Ying and Cheng, Feng and Zhang, Wenqiang}, title = {Weight-based strategy for an I/O-intensive application at a cloud data center}, series = {Concurrency and computation : practice \& experience}, volume = {30}, journal = {Concurrency and computation : practice \& experience}, number = {19}, publisher = {Wiley}, address = {Hoboken}, issn = {1532-0626}, doi = {10.1002/cpe.4648}, pages = {14}, year = {2018}, abstract = {Applications with different characteristics in the cloud may have different resources preferences. However, traditional resource allocation and scheduling strategies rarely take into account the characteristics of applications. Considering that an I/O-intensive application is a typical type of application and that frequent I/O accesses, especially small files randomly accessing the disk, may lead to an inefficient use of resources and reduce the quality of service (QoS) of applications, a weight allocation strategy is proposed based on the available resources that a physical server can provide as well as the characteristics of the applications. Using the weight obtained, a resource allocation and scheduling strategy is presented based on the specific application characteristics in the data center. Extensive experiments show that the strategy is correct and can guarantee a high concurrency of I/O per second (IOPS) in a cloud data center with high QoS. Additionally, the strategy can efficiently improve the utilization of the disk and resources of the data center without affecting the service quality of applications.}, language = {en} } @article{TraxlerHanssenLautenbacheretal.2018, author = {Traxler, Juliane and Hanssen, Marjolein M. and Lautenbacher, Stefan and Ottawa, Fabian and Peters, Madelon L.}, title = {General versus pain-specific cognitions}, series = {European journal of pain}, volume = {23}, journal = {European journal of pain}, number = {1}, publisher = {Wiley}, address = {Hoboken}, issn = {1090-3801}, doi = {10.1002/ejp.1294}, pages = {150 -- 159}, year = {2018}, abstract = {Background Previous studies found evidence that dispositional optimism is related to lower pain sensitivity. Recent findings suggest that temporarily increasing optimism by means of imagining a positive future may also have pain-alleviating effects. Objectives The present experiment was designed to investigate conditioned pain modulation (CPM) as a potential underlying mechanism of this pain-alleviating effect of induced optimism. Methods For this purpose, 45 healthy participants were randomized into an optimistic or neutral imagery condition. Additionally, participants completed questionnaires on dispositional optimism, pain catastrophizing and pain expectations. CPM was assessed by delivering a series of five heat pain stimuli on the nondominant hand before and during immersion of the dominant hand in water of 5 degrees C for 70 s. Results A clear CPM effect was found, that is heat pain reports were lower during simultaneous cold water stimulation. Although the optimism manipulation successfully increased optimism, it did not affect pain ratings or CPM. Post hoc analyses indicated that dispositional optimism was not associated with the magnitude of CPM, but pain catastrophizing and pain expectations did significantly correlate with the CPM effect. Conclusion Pain-specific but not general cognitions appear to influence endogenous pain modulation. Significance Conditioned pain modulation is not the underlying mechanism of the pain-alleviating effects of induced optimism. However, pain-specific cognitions including pain catastrophizing and pain expectations affect endogenous pain modulation which should be taken into account in treatment and CPM research.}, language = {en} } @article{MaesPerringVanhellemontetal.2018, author = {Maes, Sybryn L. and Perring, Michael P. and Vanhellemont, Margot and Depauw, Leen and Van den Bulcke, Jan and Brumelis, Guntis and Brunet, Jorg and Decocq, Guillaume and den Ouden, Jan and H{\"a}rdtle, Werner and Hedl, Radim and Heinken, Thilo and Heinrichs, Steffi and Jaroszewicz, Bogdan and Kopeck{\´y}, Martin and Malis, Frantisek and Wulf, Monika and Verheyen, Kris}, title = {Environmental drivers interactively affect individual tree growth across temperate European forests}, series = {Global change biology}, volume = {25}, journal = {Global change biology}, number = {1}, publisher = {Wiley}, address = {Hoboken}, issn = {1354-1013}, doi = {10.1111/gcb.14493}, pages = {201 -- 217}, year = {2018}, abstract = {Forecasting the growth of tree species to future environmental changes requires abetter understanding of its determinants. Tree growth is known to respond to global-change drivers such as climate change or atmospheric deposition, as well as to localland-use drivers such as forest management. Yet, large geographical scale studiesexamining interactive growth responses to multiple global-change drivers are relativelyscarce and rarely consider management effects. Here, we assessed the interactiveeffects of three global-change drivers (temperature, precipitation and nitrogen deposi-tion) on individual tree growth of three study species (Quercus robur/petraea, Fagus syl-vatica and Fraxinus excelsior). We sampled trees along spatial environmental gradientsacross Europe and accounted for the effects of management for Quercus. We collectedincrement cores from 267 trees distributed over 151 plots in 19 forest regions andcharacterized their neighbouring environment to take into account potentially confounding factors such as tree size, competition, soil conditions and elevation. Wedemonstrate that growth responds interactively to global-change drivers, with species -specific sensitivities to the combined factors. Simultaneously high levels of precipita-tion and deposition benefited Fraxinus, but negatively affected Quercus' growth, high-lighting species-specific interactive tree growth responses to combined drivers. ForFagus, a stronger growth response to higher temperatures was found when precipita-tion was also higher, illustrating the potential negative effects of drought stress underwarming for this species. Furthermore, we show that past forest management canmodulate the effects of changing temperatures on Quercus' growth; individuals in plotswith a coppicing history showed stronger growth responses to higher temperatures.Overall, our findings highlight how tree growth can be interactively determined by glo-bal-change drivers, and how these growth responses might be modulated by past for-est management. By showing future growth changes for scenarios of environmentalchange, we stress the importance of considering multiple drivers, including past man-agement and their interactions, when predicting tree growth.}, language = {en} } @article{FiedlerHainzlZoelleretal.2018, author = {Fiedler, Bernhard and Hainzl, Sebastian and Z{\"o}ller, Gert and Holschneider, Matthias}, title = {Detection of Gutenberg-Richter b-Value Changes in Earthquake Time Series}, series = {Bulletin of the Seismological Society of America}, volume = {108}, journal = {Bulletin of the Seismological Society of America}, number = {5A}, publisher = {Seismological Society of America}, address = {Albany}, issn = {0037-1106}, doi = {10.1785/0120180091}, pages = {2778 -- 2787}, year = {2018}, abstract = {The Gutenberg-Richter relation for earthquake magnitudes is the most famous empirical law in seismology. It states that the frequency of earthquake magnitudes follows an exponential distribution; this has been found to be a robust feature of seismicity above the completeness magnitude, and it is independent of whether global, regional, or local seismicity is analyzed. However, the exponent b of the distribution varies significantly in space and time, which is important for process understanding and seismic hazard assessment; this is particularly true because of the fact that the Gutenberg-Richter b-value acts as a proxy for the stress state and quantifies the ratio of large-to-small earthquakes. In our work, we focus on the automatic detection of statistically significant temporal changes of the b-value in seismicity data. In our approach, we use Bayes factors for model selection and estimate multiple change-points of the frequency-magnitude distribution in time. The method is first applied to synthetic data, showing its capability to detect change-points as function of the size of the sample and the b-value contrast. Finally, we apply this approach to examples of observational data sets for which b-value changes have previously been stated. Our analysis of foreshock and after-shock sequences related to mainshocks, as well as earthquake swarms, shows that only a portion of the b-value changes is statistically significant.}, language = {en} } @misc{GalbeteSchwingshacklSchwedhelmetal.2018, author = {Galbete, Cecilia and Schwingshackl, Lukas and Schwedhelm, Carolina and Boeing, Heiner and Schulze, Matthias Bernd}, title = {Evaluating Mediterranean diet and risk of chronic disease in cohort studies}, series = {European journal of epidemiology}, volume = {33}, journal = {European journal of epidemiology}, number = {10}, publisher = {Springer}, address = {Dordrecht}, issn = {0393-2990}, doi = {10.1007/s10654-018-0427-3}, pages = {909 -- 931}, year = {2018}, abstract = {Several meta-analyses have been published summarizing the associations of the Mediterranean diet (MedDiet) with chronic diseases. We evaluated the quality and credibility of evidence from these meta-analyses as well as characterized the different indices used to define MedDiet and re-calculated the associations with the different indices identified. We conducted an umbrella review of meta-analyses on cohort studies evaluating the association of the MedDiet with type 2 diabetes, cardiovascular disease, cancer and cognitive-related diseases. We used the AMSTAR (A MeaSurement Tool to Assess systematic Reviews) checklist to evaluate the methodological quality of the meta-analyses, and the NutriGrade scoring system to evaluate the credibility of evidence. We also identified different indices used to define MedDiet; tests for subgroup differences were performed to compare the associations with the different indices when at least 2 studies were available for different definitions. Fourteen publications were identified and within them 27 meta-analyses which were based on 70 primary studies. Almost all meta-analyses reported inverse associations between MedDiet and risk of chronic disease, but the credibility of evidence was rated low to moderate. Moreover, substantial heterogeneity was observed on the use of the indices assessing adherence to the MedDiet, but two indices were the most used ones [Trichopoulou MedDiet (tMedDiet) and alternative MedDiet (aMedDiet)]. Overall, we observed little difference in risk associations comparing different MedDiet indices in the subgroup meta-analyses. Future prospective cohort studies are advised to use more homogenous definitions of the MedDiet to improve the comparability across meta-analyses.}, language = {en} } @article{VerchHirschmuellerMuelleretal.2018, author = {Verch, Ronald and Hirschm{\"u}ller, Anja and M{\"u}ller, Juliane and Baur, Heiner and Mayer, Frank and M{\"u}ller, Steffen}, title = {Is in-toing gait physiological in children?}, series = {Gait \& posture}, volume = {66}, journal = {Gait \& posture}, publisher = {Elsevier}, address = {Clare}, issn = {0966-6362}, doi = {10.1016/j.gaitpost.2018.08.019}, pages = {70 -- 75}, year = {2018}, abstract = {Research question: This study aimed to establish reference values in 1-14 year old healthy children and to implement FPA-percentile curves for daily clinical use. Methods: 5910 healthy children performed at least 3 repetitions of barefoot walking over an instrumented walkway using a pressure measurement platform. The FPA [degrees] was extracted and analyzed by age and gender (mean +/- standard deviation; median with percentiles, MANOVA (age, gender) and Wilcoxon-Signed-Rank test for intra-individual side differences (alpha = 0.05). Results: FPA maximum was observed in 2-year-old children and diminished significant until the age of 4 to moderate out-toeing. For ages 5-14, no statistically significant differences in FPA values were present (p > 0.05). MANOVA confirmed age (p < 0.001) and gender (p < 0.001) as significant FPA influencing factors, without combined effect (p > 0.05). In every age group, right feet showed significantly greater out-toeing (p < 0.05). Significance: Percentile values indicate a wide FPA range in children. FPA development in young children shows a spontaneous shift towards moderate external rotation (age 2-4), whereby in-toeing <= 1-5 degrees can be present, but can return to normal. Bilateral in-toeing after the age of four and unilateral in-toeing after the age of seven should be monitored.}, language = {en} } @article{TapeJonesArpetal.2018, author = {Tape, Ken D. and Jones, Benjamin M. and Arp, Christopher D. and Nitze, Ingmar and Grosse, Guido}, title = {Tundra be dammed}, series = {Global change biology}, volume = {24}, journal = {Global change biology}, number = {10}, publisher = {Wiley}, address = {Hoboken}, issn = {1354-1013}, doi = {10.1111/gcb.14332}, pages = {4478 -- 4488}, year = {2018}, abstract = {Increasing air temperatures are changing the arctic tundra biome. Permafrost is thawing, snow duration is decreasing, shrub vegetation is proliferating, and boreal wildlife is encroaching. Here we present evidence of the recent range expansion of North American beaver (Castor canadensis) into the Arctic, and consider how this ecosystem engineer might reshape the landscape, biodiversity, and ecosystem processes. We developed a remote sensing approach that maps formation and disappearance of ponds associated with beaver activity. Since 1999, 56 new beaver pond complexes were identified, indicating that beavers are colonizing a predominantly tundra region (18,293km(2)) of northwest Alaska. It is unclear how improved tundra stream habitat, population rebound following overtrapping for furs, or other factors are contributing to beaver range expansion. We discuss rates and likely routes of tundra beaver colonization, as well as effects on permafrost, stream ice regimes, and freshwater and riparian habitat. Beaver ponds and associated hydrologic changes are thawing permafrost. Pond formation increases winter water temperatures in the pond and downstream, likely creating new and more varied aquatic habitat, but specific biological implications are unknown. Beavers create dynamic wetlands and are agents of disturbance that may enhance ecosystem responses to warming in the Arctic.}, language = {en} } @article{KoehlerKoehlerDeckwartetal.2018, author = {Koehler, Friedrich and Koehler, Kerstin and Deckwart, Oliver and Prescher, Sandra and Wegscheider, Karl and Winkler, Sebastian and Vettorazzi, Eik and Polze, Andreas and Stangl, Karl and Hartmann, Oliver and Marx, Almuth and Neuhaus, Petra and Scherf, Michael and Kirwan, Bridget-Anne and Anker, Stefan D.}, title = {Telemedical Interventional Management in Heart Failure II (TIM-HF2), a randomised, controlled trial investigating the impact of telemedicine on unplanned cardiovascular hospitalisations and mortality in heart failure patients}, series = {European Journal of Heart Failure}, volume = {20}, journal = {European Journal of Heart Failure}, number = {10}, publisher = {Wiley}, address = {Hoboken}, issn = {1388-9842}, doi = {10.1002/ejhf.1300}, pages = {1485 -- 1493}, year = {2018}, abstract = {Background Heart failure (HF) is a complex, chronic condition that is associated with debilitating symptoms, all of which necessitate close follow-up by health care providers. Lack of disease monitoring may result in increased mortality and more frequent hospital readmissions for decompensated HF. Remote patient management (RPM) in this patient population may help to detect early signs and symptoms of cardiac decompensation, thus enabling a prompt initiation of the appropriate treatment and care before a manifestation of HF decompensation. Objective The objective of the present article is to describe the design of a new trial investigating the impact of RPM on unplanned cardiovascular hospitalisations and mortality in HF patients. Methods The TIM-HF2 trial is designed as a prospective, randomised, controlled, parallel group, open (with randomisation concealment), multicentre trial with pragmatic elements introduced for data collection. Eligible patients with HF are randomised (1:1) to either RPM + usual care or to usual care only and are followed for 12 months. The primary outcome is the percentage of days lost due to unplanned cardiovascular hospitalisations or all-cause death. The main secondary outcomes are all-cause and cardiovascular mortality. Conclusion The TIM-HF2 trial will provide important prospective data on the potential beneficial effect of telemedical monitoring and RPM on unplanned cardiovascular hospitalisations and mortality in HF patients.}, language = {en} } @misc{AlbersUestuenWitzeletal.2018, author = {Albers, Philip and Uestuen, Suayib and Witzel, Katja and Bornke, Frederik}, title = {Identification of a novel target of the bacterial effector HopZ1a}, series = {Phytopathology}, volume = {108}, journal = {Phytopathology}, number = {10}, publisher = {American Phytopathological Society}, address = {Saint Paul}, issn = {0031-949X}, pages = {1}, year = {2018}, abstract = {The plant pathogen Pseudomonas syringae is a gram-negative bacterium which infects a wide range of plant species including important crops plants. To suppress plant immunity and cause disease P.syringae injects type-III effector proteins (T3Es) into the plant cell cytosol. In this study, we identified a novel target of the well characterized bacterial T3E HopZ1a. HopZ1a is an acetyltransferase that was shown to disrupt vesicle transport during innate immunity by acetylating tubulin. Using a yeast-two-hybrid screen approach, we identified a REMORIN (REM) protein from tobacco as a novel HopZ1a target. HopZ1a interacts with REM at the plasma membrane (PM) as shown by split-YFP experiments. Interestingly, we found that PBS1, a well-known kinase involved in plant immunity also interacts with REM in pull-down assays, and at the PM as shown by BiFC. Furthermore, we confirmed that REM is phosphorylated by PBS1 in vitro. Overexpression of REM provokes the upregulation of defense genes and leads to disease-like phenotypes pointing to a role of REM in plant immune signaling. Further protein-protein interaction studies reveal novel REM binding partners with a possible role in plant immune signaling. Thus, REM might act as an assembly hub for an immune signaling complex targeted by HopZ1a. Taken together, this is the first report describing that a REM protein is targeted by a bacterial effector. How HopZ1a might mechanistically manipulate the plant immune system through interfering with REM function will be discussed.}, language = {en} } @article{FrancoObregonCambriaGreutertetal.2018, author = {Franco-Obregon, Alfredo and Cambria, Elena and Greutert, Helen and Wernas, Timon and Hitzl, Wolfgang and Egli, Marcel and Sekiguchi, Miho and Boos, Norbert and Hausmann, Oliver and Ferguson, Stephen J. and Kobayashi, Hiroshi and W{\"u}rtz-Kozak, Karin}, title = {TRPC6 in simulated microgravity of intervertebral disc cells}, series = {European Spine Journal}, volume = {27}, journal = {European Spine Journal}, number = {10}, publisher = {Springer}, address = {New York}, issn = {0940-6719}, doi = {10.1007/s00586-018-5688-8}, pages = {2621 -- 2630}, year = {2018}, abstract = {Purpose Prolonged bed rest and microgravity in space cause intervertebral disc (IVD) degeneration. However, the underlying molecular mechanisms are not completely understood. Transient receptor potential canonical (TRPC) channels are implicated in mechanosensing of several tissues, but are poorly explored in IVDs. Methods Primary human IVD cells from surgical biopsies composed of both annulus fibrosus and nucleus pulposus (passage 1-2) were exposed to simulated microgravity and to the TRPC channel inhibitor SKF-96365 (SKF) for up to 5days. Proliferative capacity, cell cycle distribution, senescence and TRPC channel expression were analyzed. Results Both simulated microgravity and TRPC channel antagonism reduced the proliferative capacity of IVD cells and induced senescence. While significant changes in cell cycle distributions (reduction in G1 and accumulation in G2/M) were observed upon SKF treatment, the effect was small upon 3days of simulated microgravity. Finally, downregulation of TRPC6 was shown under simulated microgravity. Conclusions Simulated microgravity and TRPC channel inhibition both led to reduced proliferation and increased senescence. Furthermore, simulated microgravity reduced TRPC6 expression. IVD cell senescence and mechanotransduction may hence potentially be regulated by TRPC6 expression. This study thus reveals promising targets for future studies.}, language = {en} } @article{HoffmannCortesGarciaWarschburger2018, author = {Hoffmann, Svenja Sarah Helen and Cortes-Garcia, Laura and Warschburger, Petra}, title = {Weight/shape and muscularity concerns and emotional problems in adolescent boys and girls}, series = {Journal of adolescence}, volume = {68}, journal = {Journal of adolescence}, publisher = {Elsevier}, address = {London}, issn = {0140-1971}, doi = {10.1016/j.adolescence.2018.07.005}, pages = {70 -- 77}, year = {2018}, abstract = {Introduction: The goal of the present study was to identify the prospective relations between weight/shape and muscularity concerns and emotional problems in adolescents. Methods: Self-report data of 966 German male and female adolescents were analyzed in a cross lagged panel design. Results: Analyses of latent means revealed significant correlations between weight/shape concern and emotional problems as well as between muscularity concern and emotional problems in both genders. Moreover, weight/shape concern predicted emotional problems prospectively, but only in girls. Regarding muscularity concern, we could not find any prospective relation with emotional problems In boys or girls from the general population. Conclusions: It is assumed that as appearance is highly relevant for the self-concept in girls, concerns about the look might promote emotional problems. Thus, weight/shape concern should be addressed in the prevention of emotional problems in adolescent girls, whereas further research is necessary investigating the contribution of muscularity concern in this context.}, language = {en} } @article{EmbersonGalyHovius2018, author = {Emberson, Robert and Galy, Albert and Hovius, Niels}, title = {Weathering of Reactive Mineral Phases in Landslides Acts as a Source of Carbon Dioxide in Mountain Belts}, series = {Journal of geophysical research : Earth surface}, volume = {123}, journal = {Journal of geophysical research : Earth surface}, number = {10}, publisher = {American Geophysical Union}, address = {Washington}, issn = {2169-9003}, doi = {10.1029/2018JF004672}, pages = {2695 -- 2713}, year = {2018}, abstract = {Bedrock landsliding in mountain belts can elevate overall chemical weathering rates through rapid dissolution of exhumed reactive mineral phases in transiently stored deposits. This link between a key process of erosion and the resultant weathering affects the sequestering of carbon dioxide through weathering of silicate minerals and broader links between erosion in active orogens and climate change. Here we address the effect on the carbon cycle of weathering induced by bedrock landsliding in Taiwan and the Western Southern Alps of New Zealand. Using solute chemistry data from samples of seepage from landslide deposits and river discharge from catchments with variable proportions of landsliding, we model the proportion of silicate and carbonate weathering and the balance of sulfuric and carbonic acids that act as weathering agents. We correct for secondary precipitation, geothermal, and cyclic input, to find a closer approximation of the weathering explicitly occurring within landslide deposits. We find highly variable proportions of sulfuric and carbonic acids driving weathering in landslides and stable hillslopes. Despite this variability, the predominance of rapid carbonate weathering within landslides and catchments where mass wasting is prevalent results at best in limited sequestration of carbon dioxide by this process of rapid erosion. In many cases where sulfuric acid is a key weathering agent, a net release of CO2 to the atmosphere occurs. This suggests that a causal link between erosion in mountain belts and climate change through the sequestration of CO2, if it exists, must operate through a process other than chemical weathering driven by landsliding. Plain Language Summary There is a long-standing debate surrounding the link between erosion and climate. It is often suggested that as temperatures increase, rainier and stormier weather could increase erosion of rock; as that rock is exposed, silicate minerals within could break down, which, on long time scales, can remove CO2 from the atmosphere, lowering global temperatures and acting as a negative feedback. Recent studies have shown that landslide deposits are key locations for the link between chemical weathering and physical erosion in some mountain belts. To test how landslides affect the erosion-climate link, we used samples of water seeping through landslides in Taiwan and New Zealand to calculate the amount of carbon dioxide that is either absorbed or released through this chemical reaction. We find that the large amount of freshly exposed rock in Taiwanese landslide deposits contains significant carbonate rock and sulfide minerals; the net result of the weathering of these minerals is a release of carbon dioxide, which inverts the traditional perspective on the role erosion plays in controlling carbon dioxide release. In some mountain belts, it seems that increased erosion and resulting landsliding may act to increase carbon dioxide in the air, opening further questions into the nature of erosional-climatic links.}, language = {en} } @article{MurrayBraunReiners2018, author = {Murray, Kendra E. and Braun, Jean and Reiners, Peter W.}, title = {Toward Robust Interpretation of Low-Temperature Thermochronometers in Magmatic Terranes}, series = {Geochemistry, geophysics, geosystems}, volume = {19}, journal = {Geochemistry, geophysics, geosystems}, number = {10}, publisher = {American Geophysical Union}, address = {Washington}, issn = {1525-2027}, doi = {10.1029/2018GC007595}, pages = {3739 -- 3763}, year = {2018}, abstract = {Many regions central to our understanding of tectonics and landscape evolution are active or ancient magmatic terranes, and robust interpretation of low-temperature thermochronologic ages in these settings requires careful attention to the drivers of rock heating and cooling, including magmatism. However, we currently lack a quantitative framework for evaluating the potential role of magmatic coolingthat is, post-magmatic thermal relaxationin shaping cooling age patterns in regions with a history of intrusive magmatism. Here we use analytical approximations and numerical models to characterize how low-temperature thermochronometers document cooling inside and around plutons in steadily exhuming environments. Our models predict that the thermal field a pluton intrudes into, specifically the ambient temperatures relative to the closure temperature of a given thermochronometer, is as important as the pluton size and temperature in controlling the pattern and extent of thermochronometer resetting in the country rocks around a pluton. We identify one advective and several conductive timescales that govern the relationship between the crystallization and cooling ages inside a pluton. In synthetic vertical age-elevation relationships (AERs), resetting next to plutons results in changes in AER slope that could be misinterpreted as past changes in exhumation rate if the history of magmatism is not accounted for. Finally, we find that large midcrustal plutons, such as those emplaced at similar to 10-15-km depth, can reset the low-temperature thermochronometers far above them in the upper crusta result with considerable consequences for thermochronology in arcs and regions with a history of magmatic activity that may not have a surface expression.}, language = {en} } @article{SchmaelzlinMoralejoGersondeetal.2018, author = {Schm{\"a}lzlin, Elmar Gerd and Moralejo, Benito and Gersonde, Ingo and Schleusener, Johannes and Darvin, Maxim E. and Thiede, Gisela and Roth, Martin M.}, title = {Nonscanning large-area Raman imaging for ex vivo/in vivo skin cancer discrimination}, series = {Journal of biomedical optics}, volume = {23}, journal = {Journal of biomedical optics}, number = {10}, publisher = {SPIE}, address = {Bellingham}, issn = {1083-3668}, doi = {10.1117/1.JBO.23.10.105001}, pages = {11}, year = {2018}, abstract = {Imaging Raman spectroscopy can be used to identify cancerous tissue. Traditionally, a step-by-step scanning of the sample is applied to generate a Raman image, which, however, is too slow for routine examination of patients. By transferring the technique of integral field spectroscopy (IFS) from astronomy to Raman imaging, it becomes possible to record entire Raman images quickly within a single exposure, without the need for a tedious scanning procedure. An IFS-based Raman imaging setup is presented, which is capable of measuring skin ex vivo or in vivo. It is demonstrated how Raman images of healthy and cancerous skin biopsies were recorded and analyzed. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.}, language = {en} }