@article{PazBecerraSilvaetal.2015,
  author    = {Paz, Cristian and Becerra, Jose and Silva, Mario and Burgos, Viviana and Heydenreich, Matthias and Schmidt, Bernd and Thu Tran, and Vetter, Irina},
  title     = {(-)-Pentylsedinine, a New Alkaloid from the Leaves of Lobelia tupa with Agonist Activity at Nicotinic Acetylcholine Receptor},
  series = {Natural product communications : an international journal for communications and reviews},
  volume    = {10},
  journal   = {Natural product communications : an international journal for communications and reviews},
  number    = {8},
  publisher = {NPC},
  address   = {Westerville},
  issn      = {1934-578X},
  pages     = {1355 -- 1357},
  year      = {2015},
  abstract  = {Lobelia tupa, also called devil's tobacco, is a native plant from the center-south of Chile which has been used by the native people of Chile as a hallucinogenic and anesthetic plant. A new piperidine alkaloid, called pentylsedinine, which comprises five carbons in the side chain, was isolated from the aerial part of L. tupa, along with lobeline and lobelanidine. The structure was established on the basis of 1D and 2D NMR spectroscopy. While lobeline is a neutral antagonist at alpha 3 beta 2/alpha 3 beta 4 nAChR and alpha 7 nAChR, both lobelanidine and pentylsedinine act as partial agonists at nAChR},
  language  = {en}
}