@article{BehlZhaoLendlein2020,
  author    = {Behl, Marc and Zhao, Qian and Lendlein, Andreas},
  title     = {Glucose-responsive shape-memory cryogels},
  series = {Journal of materials research : JMR},
  volume    = {35},
  journal   = {Journal of materials research : JMR},
  number    = {18},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {0884-2914},
  doi       = {10.1557/jmr.2020.204},
  pages     = {2396 -- 2404},
  year      = {2020},
  abstract  = {Boronic ester bonds can be reversibly formed between phenylboronic acid (PBA) and triol moieties. Here, we aim at a glucose-induced shape-memory effect by implementing such bonds as temporary netpoints, which are cleavable by glucose and by minimizing the volume change upon stimulation by a porous cryogel structure. The polymer system consisted of a semi-interpenetrating network (semi-IPN) architecture, in which the triol moieties were part of the permanent network and the PBA moieties were located in the linear polymer diffused into the semi-IPN. In an alkaline medium (pH = 10), the swelling ratio was approximately 35, independent of C-glu varied between 0 and 300 mg/dL. In bending experiments, shape fixity R-f approximate to 80\% and shape recovery R-r approximate to 100\% from five programming/recovery cycles could be determined. R-r was a function of C-glu in the range from 0 to 300 mg/dL, which accords with the fluctuation range of C-glu in human blood. In this way, the shape-memory hydrogels could play a role in future diabetes treatment options.},
  language  = {en}
}