@article{HortobagyiLesinskiGaebleretal.2015, author = {Hortob{\´a}gyi, Tibor and Lesinski, Melanie and G{\"a}bler, Martijn and VanSwearingen, Jessie M. and Malatesta, Davide and Granacher, Urs}, title = {Effects of three types of exercise interventions on healthy old adults' gait speed}, series = {Sports medicine}, volume = {45}, journal = {Sports medicine}, publisher = {Springer}, address = {Berlin}, issn = {1179-2035}, doi = {10.1007/s40279-015-0371-2}, pages = {1627 -- 1643}, year = {2015}, abstract = {Background: Habitual walking speed predicts many clinical conditions later in life, but it declines with age. However, which particular exercise intervention can minimize the age-related gait speed loss is unclear. Purpose: Our objective was to determine the effects of strength, power, coordination, and multimodal exercise training on healthy old adults' habitual and fast gait speed. Methods: We performed a computerized systematic literature search in PubMed and Web of Knowledge from January 1984 up to December 2014. Search terms included 'Resistance training', 'power training', 'coordination training', 'multimodal training', and 'gait speed (outcome term). Inclusion criteria were articles available in full text, publication period over past 30 years, human species, journal articles, clinical trials, randomized controlled trials, English as publication language, and subject age C65 years. The methodological quality of all eligible intervention studies was assessed using the Physiotherapy Evidence Database (PEDro) scale. We computed weighted average standardized mean differences of the intervention-induced adaptations in gait speed using a random-effects model and tested for overall and individual intervention effects relative to no-exercise controls. Results: A total of 42 studies (mean PEDro score of 5.0 +/- 1.2) were included in the analyses (2495 healthy old adults; age 74.2 years [64.4-82.7]; body mass 69.9 +/- 4.9 kg, height 1.64 +/- 0.05 m, body mass index 26.4 +/- 1.9 kg/m(2), and gait speed 1.22 +/- 0.18 m/s). The search identified only one power training study, therefore the subsequent analyses focused only on the effects of resistance, coordination, and multimodal training on gait speed. The three types of intervention improved gait speed in the three experimental groups combined (n = 1297) by 0.10 m/s (+/- 0.12) or 8.4 \% (+/- 9.7), with a large effect size (ES) of 0.84. Resistance (24 studies; n = 613; 0.11 m/s; 9.3 \%; ES: 0.84), coordination (eight studies, n = 198; 0.09 m/s; 7.6 \%; ES: 0.76), and multimodal training (19 studies; n = 486; 0.09 m/s; 8.4 \%, ES: 0.86) increased gait speed statistically and similarly. Conclusions: Commonly used exercise interventions can functionally and clinically increase habitual and fast gait speed and help slow the loss of gait speed or delay its onset.}, language = {en} } @misc{HortobagyiLesinskiGaebleretal.2015, author = {Hortob{\´a}gyi, Tibor and Lesinski, Melanie and G{\"a}bler, Martijn and VanSwearingen, Jessie M. and Malatesta, Davide and Granacher, Urs}, title = {Effects of three types of exercise interventions on healthy old adults' gait speed}, series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, issn = {1866-8364}, doi = {10.25932/publishup-43115}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-431150}, pages = {17}, year = {2015}, abstract = {Background: Habitual walking speed predicts many clinical conditions later in life, but it declines with age. However, which particular exercise intervention can minimize the age-related gait speed loss is unclear. Purpose: Our objective was to determine the effects of strength, power, coordination, and multimodal exercise training on healthy old adults' habitual and fast gait speed. Methods: We performed a computerized systematic literature search in PubMed and Web of Knowledge from January 1984 up to December 2014. Search terms included 'Resistance training', 'power training', 'coordination training', 'multimodal training', and 'gait speed (outcome term). Inclusion criteria were articles available in full text, publication period over past 30 years, human species, journal articles, clinical trials, randomized controlled trials, English as publication language, and subject age C65 years. The methodological quality of all eligible intervention studies was assessed using the Physiotherapy Evidence Database (PEDro) scale. We computed weighted average standardized mean differences of the intervention-induced adaptations in gait speed using a random-effects model and tested for overall and individual intervention effects relative to no-exercise controls. Results: A total of 42 studies (mean PEDro score of 5.0 +/- 1.2) were included in the analyses (2495 healthy old adults; age 74.2 years [64.4-82.7]; body mass 69.9 +/- 4.9 kg, height 1.64 +/- 0.05 m, body mass index 26.4 +/- 1.9 kg/m(2), and gait speed 1.22 +/- 0.18 m/s). The search identified only one power training study, therefore the subsequent analyses focused only on the effects of resistance, coordination, and multimodal training on gait speed. The three types of intervention improved gait speed in the three experimental groups combined (n = 1297) by 0.10 m/s (+/- 0.12) or 8.4 \% (+/- 9.7), with a large effect size (ES) of 0.84. Resistance (24 studies; n = 613; 0.11 m/s; 9.3 \%; ES: 0.84), coordination (eight studies, n = 198; 0.09 m/s; 7.6 \%; ES: 0.76), and multimodal training (19 studies; n = 486; 0.09 m/s; 8.4 \%, ES: 0.86) increased gait speed statistically and similarly. Conclusions: Commonly used exercise interventions can functionally and clinically increase habitual and fast gait speed and help slow the loss of gait speed or delay its onset.}, language = {en} } @misc{Kittel2015, author = {Kittel, Ren{\´e}}, title = {Therapeutisches Klettern - das Praxisbuch}, edition = {2}, publisher = {TKS-Verlag}, address = {Bad Feilnbach}, isbn = {978-3-9817341-0-2}, pages = {118}, year = {2015}, abstract = {Das Prasxisbuch ist DER praktische Ratgeber zum Thema Therapeutisches Klettern. In konkreten Anwendungsbeispielen werden genau beschriebene Therapieboulder vorgestellt. Behandelt werden dabei: Wirbels{\"a}ule, Schultergelenk, Kniegelenk und Sprunggelenk. Praktische Hinweise zu Therapiekletterw{\"a}nden und Therapieklettergriffen, sowie Informationen zu Physiologoie und Anatomie sind ebenfalls enthalten. Therapeutisches Klettern - Das Praxisbuch vermittelt die n{\"o}tigen Kenntnisse um mit Patienten an der Therapie Kletterwand arbeiten zu k{\"o}nnen.}, language = {de} } @article{PrieskeMuehlbauerKruegeretal.2015, author = {Prieske, Olaf and M{\"u}hlbauer, Thomas and Kr{\"u}ger, Tom and Kibele, Armin and Behm, David George and Granacher, Urs}, title = {Role of the trunk during drop jumps on stable and unstable surfaces}, series = {European journal of applied physiology}, volume = {115}, journal = {European journal of applied physiology}, number = {1}, publisher = {Springer}, address = {New York}, issn = {1439-6319}, doi = {10.1007/s00421-014-3004-9}, pages = {139 -- 146}, year = {2015}, abstract = {The present study investigated associations between trunk muscle strength, jump performance, and lower limb kinematics during drop jumps on stable and unstable surfaces. Next to this behavioral approach, correlations were also computed on a neuromuscular level between trunk and leg muscle activity during the same test conditions. Twenty-nine healthy and physically active subjects (age 23 +/- A 3 years) were enrolled in this study. Peak isokinetic torque (PIT) of the trunk flexors and extensors was assessed separately on an isokinetic device. In addition, tests included drop jumps (DJ) on a force plate under stable and unstable (i.e., balance pad on top of the force plate) surfaces. Lower limb kinematics as well as electromyographic activity of selected trunk and leg muscles were analyzed. Significant positive but small correlations (0.50 a parts per thousand currency sign r a parts per thousand currency sign 0.66, p < 0.05) were detected between trunk extensor PIT and athletic performance measures (i.e., DJ height, DJ performance index), irrespective of surface condition. Further, significant negative but small correlation coefficients were examined between trunk extensor PIT and knee valgus motion under stable and unstable surface conditions (-0.48 a parts per thousand currency sign r a parts per thousand currency sign -0.45, p < 0.05). In addition, significant positive but small correlations (0.45 a parts per thousand currency sign r a parts per thousand currency sign 0.68, p < 0.05) were found between trunk and leg muscle activity, irrespective of surface condition. Behavioral and neuromuscular data from this study indicate that, irrespective of the surface condition (i.e., jumping on stable or unstable ground), the trunk plays a minor role for leg muscle performance/activity during DJ. This implies only limited effects of trunk muscle strengthening on jump performance in the stretch-shortening cycle.}, language = {en} } @article{HaegeleSchlagenhaufRappetal.2015, author = {Haegele, Claudia and Schlagenhauf, Florian and Rapp, Michael A. and Sterzer, Philipp and Beck, Anne and Bermpohl, Felix and Stoy, Meline and Stroehle, Andreas and Wittchen, Hans-Ulrich and Dolan, Raymond J. and Heinz, Andreas}, title = {Dimensional psychiatry: reward dysfunction and depressive mood across psychiatric disorders}, series = {Psychopharmacology}, volume = {232}, journal = {Psychopharmacology}, number = {2}, publisher = {Springer}, address = {New York}, issn = {0033-3158}, doi = {10.1007/s00213-014-3662-7}, pages = {331 -- 341}, year = {2015}, abstract = {A dimensional approach in psychiatry aims to identify core mechanisms of mental disorders across nosological boundaries. We compared anticipation of reward between major psychiatric disorders, and investigated whether reward anticipation is impaired in several mental disorders and whether there is a common psychopathological correlate (negative mood) of such an impairment. During reward anticipation, we observed significant group differences in ventral striatal (VS) activation: patients with schizophrenia, alcohol dependence, and major depression showed significantly less ventral striatal activation compared to healthy controls. Depressive symptoms correlated with dysfunction in reward anticipation regardless of diagnostic entity. There was no significant correlation between anxiety symptoms and VS functional activation. Our findings demonstrate a neurobiological dysfunction related to reward prediction that transcended disorder categories and was related to measures of depressed mood. The findings underline the potential of a dimensional approach in psychiatry and strengthen the hypothesis that neurobiological research in psychiatric disorders can be targeted at core mechanisms that are likely to be implicated in a range of clinical entities.}, language = {en} } @article{PrieskeMuehlbauerKruegeretal.2015, author = {Prieske, Olaf and M{\"u}hlbauer, Thomas and Kr{\"u}ger, Tom and Kibele, A. and Behm, David George and Granacher, Urs}, title = {Sex-Specific effects of surface instability on drop jump and landing biomechanics}, series = {International journal of sports medicine}, volume = {36}, journal = {International journal of sports medicine}, number = {1}, publisher = {Thieme}, address = {Stuttgart}, issn = {0172-4622}, doi = {10.1055/s-0034-1384549}, pages = {75 -- 81}, year = {2015}, abstract = {This study investigated sex-specific effects of surface instability on kinetics and lower extremity kinematics during drop jumping and landing. Ground reaction forces as well as knee valgus and flexion angles were tested in 14 males (age: 23 +/- 2 years) and 14 females (age: 24 +/- 3 years) when jumping and landing on stable and unstable surfaces. Jump height was found to be significantly lower (9 \%, p < 0.001) when drop jumps were performed on unstable vs. stable surface. Significantly higher peak ground reaction forces were observed when jumping was performed on unstable vs. stable surfaces (5 \%, p = 0.022). Regarding frontal plane kinematics during jumping and landing, knee valgus angles were higher on unstable compared to stable surfaces (1932 \%, p < 0.05). Additionally, at the onset of ground contact during landings, females showed higher knee valgus angles than males (222 \%, p = 0.027). Sagittal plane kinematics indicated significantly smaller knee flexion angles (6-35 \%, p < 0.05) when jumping and landing on unstable vs. stable surfaces. During drop jumps and landings, women showed smaller knee flexion angles at ground contact compared to men (27-33 \%, p < 0.05). These findings imply that knee motion strategies were modified by surface instability and sex during drop jumps and landings.}, language = {en} } @article{HoffSchaeferHeinkeetal.2015, author = {Hoff, Marko and Schaefer, Laura and Heinke, Nancy and Bittmann, Frank}, title = {Report on adaptive force, a specific neuromuscular function}, series = {European journal of translational myology}, volume = {25}, journal = {European journal of translational myology}, number = {3}, publisher = {PAGEPress}, address = {Pavia}, issn = {2037-7452}, doi = {10.4081/ejtm.2015.5183}, pages = {183 -- 189}, year = {2015}, language = {en} } @article{IntziegianniCasselKoenigetal.2015, author = {Intziegianni, Konstantina and Cassel, Michael and K{\"o}nig, Niklas and M{\"u}ller, Steffen and Fr{\"o}hlich, Katja and Mayer, Frank}, title = {Ultrasonography for the assessment of the structural properties of the Achilles tendon in asymptomatic individuals: An intra-rater reproducibility study}, series = {Isokinetics and exercise science : official journal of the European Isokinetic Society}, volume = {23}, journal = {Isokinetics and exercise science : official journal of the European Isokinetic Society}, number = {4}, publisher = {IOS Press}, address = {Amsterdam}, issn = {0959-3020}, doi = {10.3233/IES-150586}, pages = {263 -- 270}, year = {2015}, abstract = {BACKGROUND: Reproducible measurements of tendon structural properties are a prerequisite for accurate diagnosis of tendon disorders and for determination of their mechanical properties. Despite the widely used application of Ultrasonography (US) in musculoskeletal assessment, its operator dependency and lack of standardization influences the consistency of the measurement. OBJECTIVE: To evaluate the intra-rater reproducibility of a standardized US method assessing the structural properties of the Achilles tendon (AT). METHODS: Sixteen asymptomatic participants were positioned prone on an isokinetic dynamometer with the knee extended and ankle at 90. flexion. US was used to assess AT-length, cross-sectional area (CSA), and AT-elongation during isometric plantarflexion contraction. The intra-rater reproducibility was assessed by ICC (2.1), Test-Retest Variability (TRV, \%), Bland-Altman analyses (Bias +/- LoA [1.96*SD]), and Standard-Error of Measurement (SEM). RESULTS: Measurements of AT-length demonstrated an ICC of 0.93, TRV of 4.5 +/- 3.9\%, Bias +/- LoA of -2.8 +/- 25.0 mm and SEM of 6.6 mm. AT-CSA showed an ICC of 0.79, TRV of 8.7 +/- 9.6\%, Bias +/- LoA of 1.7 +/- 19.4 mm(2) and SEM of 5.3 mm(2). AT-elongation revealed an ICC of 0.92, TRV of 12.9 +/- 8.9\%, Bias +/- LoA of 0.3 +/- 5.7 mm and SEM of 1.5 mm. CONCLUSIONS: The presented methodology allows a reproducible assessment of Achilles tendon structural properties when performed by a single rater.}, language = {en} } @misc{PiepoliCorraAbreuetal.2015, author = {Piepoli, Massimo F. and Corra, Ugo and Abreu, Ana and Cupples, Margaret and Davos, Costantinos and Doherty, Patrick and Hoefer, Stephan and Garcia-Porrero, Esteban and Rauchi, Bernhard and Vigorito, Carlo and V{\"o}ller, Heinz and Schmid, Jean-Paul}, title = {Challenges in secondary prevention of cardiovascular diseases A review of the current practice}, series = {International journal of cardiology}, volume = {180}, journal = {International journal of cardiology}, publisher = {Elsevier}, address = {Clare}, organization = {European Assoc Cardiovasc Preventi}, issn = {0167-5273}, doi = {10.1016/j.ijcard.2014.11.107}, pages = {114 -- 119}, year = {2015}, abstract = {With the changing demography of populations and increasing prevalence of co-morbidity, frail patients and more complex cardiac conditions, the modern medicine is facing novel challenges leading to rapid innovation where evidence and experiences are lacking. This scenario is also evident in cardiovascular disease prevention, which continuously needs to accommodate its ever changing strategies, settings, and goals. The present paper summarises actual challenges of secondary prevention, and discusses how this intervention should not only be effective but also efficient. By this way the paper tries to bridge the gaps between research and real-world findings and thereby may find ways to improve standard care. (C) 2014 Elsevier Ireland Ltd. All rights reserved.}, language = {en} } @article{TreuschMajicPageetal.2015, author = {Treusch, Yvonne and Majic, Tomislav and Page, Julie and Gutzmann, Hans and Heinz, Andreas and Rapp, Michael A.}, title = {Apathy in nursing home residents with dementia: Results from a cluster-randomized controlled trial}, series = {European psychiatry : the journal of the Association of European Psychiatrists}, volume = {30}, journal = {European psychiatry : the journal of the Association of European Psychiatrists}, number = {2}, publisher = {Elsevier}, address = {Paris}, issn = {0924-9338}, doi = {10.1016/j.eurpsy.2014.02.004}, pages = {7}, year = {2015}, abstract = {Purpose: Here we evaluate an interdisciplinary occupational and sport therapy intervention for dementia patients suffering from apathy. Subjects and methods: A prospective, controlled, rater-blinded, clinical trial with two follow-ups was conducted as part of a larger cluster-randomized trial in 18 nursing homes in Berlin. n = 117 dementia patients with apathy, defined as a score of 40 or more on the apathy evaluation scale (AES) or presence of apathy on the Neuropsychiatric Inventory (NPI), were randomly assigned to intervention or control group. The intervention included 10 months of brief activities, provided once a week. The primary outcome measure was the total score on the AES scale measured directly after the intervention period and again after 12 months. Results: We found significant group differences with respect to apathy during the 10 month intervention period (F-2,F-82 = 7.79, P < 0.01), which reflected an increase in apathy in the control group, but not in the intervention group. Within one year after the intervention was ceased, the treatment group worsened and no longer differed significantly from the control group (P = 0.55). Conclusions: Our intervention was effective for the therapy of apathy in dementia, when applied, but not one year after cessation of therapy. (C) 2014 Elsevier Masson SAS. All rights reserved.}, language = {en} } @article{FriedelSchlagenhaufBecketal.2015, author = {Friedel, Eva and Schlagenhauf, Florian and Beck, Anne and Dolan, Raymond J. and Huys, Quentin J. M. and Rapp, Michael A. and Heinz, Andreas}, title = {The effects of life stress and neural learning signals on fluid intelligence}, series = {European archives of psychiatry and clinical neuroscience : official organ of the German Society for Biological Psychiatry}, volume = {265}, journal = {European archives of psychiatry and clinical neuroscience : official organ of the German Society for Biological Psychiatry}, number = {1}, publisher = {Springer}, address = {Heidelberg}, issn = {0940-1334}, doi = {10.1007/s00406-014-0519-3}, pages = {35 -- 43}, year = {2015}, abstract = {Fluid intelligence (fluid IQ), defined as the capacity for rapid problem solving and behavioral adaptation, is known to be modulated by learning and experience. Both stressful life events (SLES) and neural correlates of learning [specifically, a key mediator of adaptive learning in the brain, namely the ventral striatal representation of prediction errors (PE)] have been shown to be associated with individual differences in fluid IQ. Here, we examine the interaction between adaptive learning signals (using a well-characterized probabilistic reversal learning task in combination with fMRI) and SLES on fluid IQ measures. We find that the correlation between ventral striatal BOLD PE and fluid IQ, which we have previously reported, is quantitatively modulated by the amount of reported SLES. Thus, after experiencing adversity, basic neuronal learning signatures appear to align more closely with a general measure of flexible learning (fluid IQ), a finding complementing studies on the effects of acute stress on learning. The results suggest that an understanding of the neurobiological correlates of trait variables like fluid IQ needs to take socioemotional influences such as chronic stress into account.}, language = {en} } @unpublished{HeinzCharletRapp2015, author = {Heinz, Andreas and Charlet, Katrin and Rapp, Michael A.}, title = {Public mental health: a call to action}, series = {World psychiatry}, volume = {14}, journal = {World psychiatry}, number = {1}, publisher = {Wiley-Blackwell}, address = {Hoboken}, issn = {1723-8617}, doi = {10.1002/wps.20182}, pages = {49 -- 50}, year = {2015}, language = {en} } @article{RoehrigSalzwedelLinckEleftheriadisetal.2015, author = {R{\"o}hrig, Bernd and Salzwedel, Annett and Linck-Eleftheriadis, Sigrid and V{\"o}ller, Heinz and Nosper, Manfred}, title = {Outcome Based Center Comparisons in Inpatient Cardiac Rehabilitation Results from the EVA-Reha (R) Cardiology Project}, series = {Die Rehabilitation : Zeitschrift f{\"u}r Praxis und Forschung in der Rehabilitation}, volume = {54}, journal = {Die Rehabilitation : Zeitschrift f{\"u}r Praxis und Forschung in der Rehabilitation}, number = {1}, publisher = {Thieme}, address = {Stuttgart}, issn = {0034-3536}, doi = {10.1055/s-0034-1395556}, pages = {45 -- 52}, year = {2015}, abstract = {Background: So far, for center comparisons in inpatient cardiac rehabilitation (CR), the objective outcome quality was neglected because of challenges in quantifying the overall success of CR. In this article, a multifactorial benchmark model measuring the individual rehabilitation success is presented. Methods: In 21 rehabilitation centers, 5 123 patients were consecutively enrolled between 01/2010 and 12/2012 in the prospective multicenter registry EVA-Reha (R) Cardiology. Changes in 13 indicators in the areas cardiovascular risk factors, physical performance and subjective health during rehabilitation were evaluated according to levels of severity. Changes were only rated for patients who needed a medical intervention. Additionally, the changes had to be clinically relevant. Therefore Minimal Important Differences (MID) were predefined. Ratings were combined to a single score, the multiple outcome criterion (MEK). Results: The MEK was determined for all patients (71.7 +/- 7.4 years, 76.9 \% men) and consisted of an average of 5.6 indicators. After risk adjustment for sociodemographic and clinical baseline parameters, MEK was used for center ranking. In addition, individual results of indicators were compared with means of all study sites. Conclusion: With the method presented here, the outcome quality can be quantified and outcome-based comparisons of providers can be made.}, language = {de} } @article{HeidlerBiduFriedrichetal.2015, author = {Heidler, Maria-Dorothea and Bidu, Laura and Friedrich, Nele and V{\"o}ller, Heinz}, title = {Oral feeding of long-term ventilated patients with a tracheotomy tube. Underestimated danger of dysphagia}, series = {Medizinische Klinik, Intensivmedizin und Notfallmedizin}, volume = {110}, journal = {Medizinische Klinik, Intensivmedizin und Notfallmedizin}, number = {1}, publisher = {Springer}, address = {New York}, issn = {2193-6218}, doi = {10.1007/s00063-014-0397-5}, pages = {55 -- 60}, year = {2015}, abstract = {In long-term mechanically ventilated patients, dysphagia is a common and potentially life-threatening complication, which can lead to aspiration and pneumonia. Nevertheless, many intensive care unit (ICU) patients are fed by mouth without evaluation of their deglutition capability. The goal of this work was to evaluate the prevalence of aspiration due to swallowing disorders in long-term ventilated patients who were fed orally in the ICU while having a blocked tracheotomy tube. In all, 43 patients participated-each underwent a fiberoptic investigation of deglutition on the day of admission to the rehabilitation clinic. A total of 65 \% of the patients aspirated, 71 \% of these silently. There were no associations between aspiration and any of the following: gender, indication for mechanical ventilation (underlying disease) or the duration of intubation and ventilation by tracheotomy tube. However, the association between aspiration and age was statistically significant (p = 0.041). Aspirating patients were older (arithmetic mean = 70 years, median = 74 years) than patients who did not aspirate (arithmetic mean = 66 years, median = 67 years). Intubation and add-on tracheotomies can lead to potentially life-threatening swallowing disorders that cause aspiration, independent of the underlying disease. Before feeding long-term mechanically ventilated patients by mouth, their ability to swallow needs to be investigated using fiberoptic endoscopic evaluation of swallowing (FEES) or a saliva dye test, if a cuff deflation and the use of a speaking valve are possible during spontaneous respiration.}, language = {de} } @article{DesernoBeckHuysetal.2015, author = {Deserno, Lorenz and Beck, Anne and Huys, Quentin J. M. and Lorenz, Robert C. and Buchert, Ralph and Buchholz, Hans-Georg and Plotkin, Michail and Kumakara, Yoshitaka and Cumming, Paul and Heinze, Hans-Jochen and Grace, Anthony A. and Rapp, Michael A. and Schlagenhauf, Florian and Heinz, Andreas}, title = {Chronic alcohol intake abolishes the relationship between dopamine synthesis capacity and learning signals in the ventral striatum}, series = {European journal of neuroscience}, volume = {41}, journal = {European journal of neuroscience}, number = {4}, publisher = {Wiley-Blackwell}, address = {Hoboken}, issn = {0953-816X}, doi = {10.1111/ejn.12802}, pages = {477 -- 486}, year = {2015}, abstract = {Drugs of abuse elicit dopamine release in the ventral striatum, possibly biasing dopamine-driven reinforcement learning towards drug-related reward at the expense of non-drug-related reward. Indeed, in alcohol-dependent patients, reactivity in dopaminergic target areas is shifted from non-drug-related stimuli towards drug-related stimuli. Such hijacked' dopamine signals may impair flexible learning from non-drug-related rewards, and thus promote craving for the drug of abuse. Here, we used functional magnetic resonance imaging to measure ventral striatal activation by reward prediction errors (RPEs) during a probabilistic reversal learning task in recently detoxified alcohol-dependent patients and healthy controls (N=27). All participants also underwent 6-[F-18]fluoro-DOPA positron emission tomography to assess ventral striatal dopamine synthesis capacity. Neither ventral striatal activation by RPEs nor striatal dopamine synthesis capacity differed between groups. However, ventral striatal coding of RPEs correlated inversely with craving in patients. Furthermore, we found a negative correlation between ventral striatal coding of RPEs and dopamine synthesis capacity in healthy controls, but not in alcohol-dependent patients. Moderator analyses showed that the magnitude of the association between dopamine synthesis capacity and RPE coding depended on the amount of chronic, habitual alcohol intake. Despite the relatively small sample size, a power analysis supports the reported results. Using a multimodal imaging approach, this study suggests that dopaminergic modulation of neural learning signals is disrupted in alcohol dependence in proportion to long-term alcohol intake of patients. Alcohol intake may perpetuate itself by interfering with dopaminergic modulation of neural learning signals in the ventral striatum, thus increasing craving for habitual drug intake.}, language = {en} } @article{ReibisJannowitzHalleetal.2015, author = {Reibis, Rona Katharina and Jannowitz, Christina and Halle, Martin and Pittrow, David and Gitt, Anselm and V{\"o}ller, Heinz}, title = {Management and outcomes of patients with reduced ejection fraction after acute myocardial infarction in cardiac rehabilitation centers}, series = {Current medical research and opinion}, volume = {31}, journal = {Current medical research and opinion}, number = {2}, publisher = {Taylor \& Francis Group}, address = {London}, issn = {0300-7995}, doi = {10.1185/03007995.2014.977854}, pages = {211 -- 219}, year = {2015}, abstract = {Background: We aimed to describe the contemporary management of patients with systolic chronic heart failure (CHF) during a cardiac rehabilitation (CR) stay and present outcomes with focus on lipids, blood pressure, exercise capacity, and clinical events. Methods: Comparison of 3199 patients with moderately or severely impaired left ventricular ejection fraction (low EF, 13.3\%) and 20,913 patients with slightly reduced or normal LVEF (normal EF, 86.7\%) who underwent an inpatient CR period of about 3 weeks in 2009-2010. Results: Patients with low EF compared to those with normal EF were somewhat older (65.1 vs. 63.0 years, p<0.0001), and more often had risk factors such as diabetes mellitus (39.7\% vs. 32.0\%, p<0.0001) or other comorbidities. The overall rate of patients with regular physical activity of at least 90 minutes per week prior to CR was low overall (54.4\%), and reduced in patients with low EF compared to those with normal EF (47.7\% vs. 55.5\%, p<0.0001). The rate of patients that achieved lower LDL cholesterol (5100 mg/dl), total cholesterol (<200 mg/dl) and triglyceride (<150 mg/dl) values at discharge increased compared to baseline. Mean blood pressure was substantially lower in the low EF group compared to the normal EF group both at baseline (124/75 vs. 130/78 mmHg, p<0.0001) and at discharge (119/72 vs. 124/74 mmHg, p<0.0001). Maximum exercise improved substantially in both groups (at baseline 71 vs. 91 Watts, p<0.0001; at discharge 85 vs. 105 Watts, p<0.0001). Event rates during CR were low, and only 0.3\% in the low EF group died. As limitations to this study, information on brain natriuretic peptide (BNP), N-terminal pro-brain natriuretic peptide (NT-pro BNP) and/or cardiac troponin were not documented, and no long-term information was collected beyond the 3-week CR stay. Conclusions: Patients with CHF account for a considerable proportion of patients in CR. Also patients with moderate/severe EF benefited from participation in CR, as their lipid profile and physical fitness improved.}, language = {en} } @article{BrandSchweizer2015, author = {Brand, Ralf and Schweizer, Geoffrey}, title = {Going to the Gym or to the Movies?: Situated Decisions as a Functional Link Connecting Automatic and Reflective Evaluations of Exercise With Exercising Behavior}, series = {Journal of sport \& exercise psychology}, volume = {37}, journal = {Journal of sport \& exercise psychology}, number = {1}, publisher = {Human Kinetics Publ.}, address = {Champaign}, issn = {0895-2779}, doi = {10.1123/jsep.2014-0018}, pages = {63 -- 73}, year = {2015}, abstract = {The goal of the present paper is to propose a model for the study of automatic cognition and affect in exercise. We have chosen a dual-system approach to social information processing to investigate the hypothesis that situated decisions between behavioral alternatives form a functional link between automatic and reflective evaluations and the time spent on exercise. A new questionnaire is introduced to operationalize this link. A reaction-time based evaluative priming task was used to test participants' automatic evaluations. Affective and cognitive reflective evaluations, as well as exercising time, were requested via self-report. Path analyses suggest that the affective reflective (beta =.71) and the automatic evaluation (beta =.15) independently explain situated decisions, which, in turn (beta =.60) explain time spent on exercise. Our findings highlight the concept of contextualized decisions. They can serve as a starting point from which the so far seldom investigations of automatic cognition and affect in exercise can be integrated with multitudinous results from studies on reflective psychological determinants of health behavior.}, language = {en} } @article{DiehlMayerMayeretal.2015, author = {Diehl, Katharina and Mayer, Manfred and Mayer, Frank and G{\"o}rig, Tatiana and Bock, Christina and Herr, Raphael M. and Schneider, Sven}, title = {Physical Activity Counseling by Primary Care Physicians: Attitudes, Knowledge, Implementation, and Perceived Success}, series = {Journal of physical activity and health}, volume = {12}, journal = {Journal of physical activity and health}, number = {2}, publisher = {Human Kinetics Publ.}, address = {Champaign}, issn = {1543-3080}, doi = {10.1123/jpah.2013-0273}, pages = {216 -- 223}, year = {2015}, abstract = {Background: In physical activity (PA) counseling, primary care physicians (PCPs) play a key role because they are in regular contact with large sections of the population and are important contact people in all health-related issues. However, little is known about their attitudes, knowledge, and perceived success, as well as about factors associated with the implementation of PA counseling. Methods: We collected data from 4074 PCPs including information on physician and practice characteristics, attitudes toward cardiovascular disease (CVD) prevention, and measures used during routine practice to prevent CVD. Here, we followed widely the established 5 A's strategy (Assess, Advise, Agree, Assist, Arrange). Results: The majority (87.2\%) of PCPs rated their own level of competence in PA counseling as 'high,' while 52.3\% rated their own capability to motivate patients to increase PA as 'not good.' Nine of ten PCPs routinely provided at least 1 measure of the modified 5 A's strategy, while 9.5\% routinely used all 5 intervention strategies. Conclusions: The positive attitude toward PA counseling among PCPs should be supported by other stakeholders in the field of prevention and health promotion. An example would be the reimbursement of health counseling services by compulsory health insurance, which would enable PCPs to invest more time in individualized health promotion.}, language = {en} } @inproceedings{BraunSawadaPinketal.2015, author = {Braun, Monique and Sawada, Stefanie and Pink, Mario and Meckert, Christine and Oberemm, Axel and Braeuning, Albert and Lampen, Alfonso}, title = {Proteomic analysis of 3-MCPD and its palmitic ester in rat kidney using a refined tissue extraction method}, series = {NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY}, volume = {388}, booktitle = {NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY}, publisher = {Springer}, address = {New York}, issn = {0028-1298}, pages = {S88 -- S88}, year = {2015}, language = {en} } @article{BeurskensGollhoferMuehlbaueretal.2015, author = {Beurskens, Rainer and Gollhofer, Albert and M{\"u}hlbauer, Thomas and Cardinale, Marco and Granacher, Urs}, title = {Effects of Heavy-Resistance Strength and Balance Training on Unilateral and Bilateral Leg Strength Performance in Old Adults}, series = {PLoS one}, volume = {10}, journal = {PLoS one}, number = {2}, publisher = {PLoS}, address = {San Fransisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0118535}, pages = {13}, year = {2015}, abstract = {The term "bilateral deficit" (BLD) has been used to describe a reduction in performance during bilateral contractions when compared to the sum of identical unilateral contractions. In old age, maximal isometric force production (MIF) decreases and BLD increases indicating the need for training interventions to mitigate this impact in seniors. In a cross-sectional approach, we examined age-related differences in MIF and BLD in young (age: 20-30 years) and old adults (age: > 65 years). In addition, a randomized-controlled trial was conducted to investigate training-specific effects of resistance vs. balance training on MIF and BLD of the leg extensors in old adults. Subjects were randomly assigned to resistance training (n = 19), balance training (n = 14), or a control group (n = 20). Bilateral heavy-resistance training for the lower extremities was performed for 13 weeks (3 x /week) at 80\% of the one repetition maximum. Balance training was conducted using predominately unilateral exercises on wobble boards, soft mats, and uneven surfaces for the same duration. Pre-and post-tests included uni-and bilateral measurements of maximal isometric leg extension force. At baseline, young subjects outperformed older adults in uni-and bilateral MIF (all p < .001; d = 2.61-3.37) and in measures of BLD (p < .001; d = 2.04). We also found significant increases in uni-and bilateral MIF after resistance training (all p < .001, d = 1.8-5.7) and balance training (all p < .05, d = 1.3-3.2). In addition, BLD decreased following resistance (p < .001, d = 3.4) and balance training (p < .001, d = 2.6). It can be concluded that both training regimens resulted in increased MIF and decreased BLD of the leg extensors (HRT-group more than BAL-group), almost reaching the levels of young adults.}, language = {en} }