@article{HaemaelaeinenDammhahnAujardetal.2014,
  author    = {Haemaelaeinen, Anni and Dammhahn, Melanie and Aujard, Fabienne and Eberle, Manfred and Hardy, Isabelle and Kappeler, Peter M. and Perret, Martine and Schliehe-Diecks, Susanne and Kraus, Cornelia},
  title     = {Senescence or selective disappearance? Age trajectories of body mass in wild and captive populations of a small-bodied primate},
  series = {Proceedings of the Royal Society of London : B, Biological sciences},
  volume    = {281},
  journal   = {Proceedings of the Royal Society of London : B, Biological sciences},
  number    = {1791},
  publisher = {Royal Society},
  address   = {London},
  issn      = {0962-8452},
  doi       = {10.1098/rspb.2014.0830},
  pages     = {10},
  year      = {2014},
  abstract  = {Classic theories of ageing consider extrinsic mortality (EM) a major factor in shaping longevity and ageing, yet most studies of functional ageing focus on species with low EM. This bias may cause overestimation of the influence of senescent declines in performance over condition-dependent mortality on demographic processes across taxa. To simultaneously investigate the roles of functional senescence (FS) and intrinsic, extrinsic and condition-dependent mortality in a species with a high predation risk in nature, we compared age trajectories of body mass (BM) in wild and captive grey mouse lemurs (Microcebus murinus) using longitudinal data (853 individuals followed through adulthood). We found evidence of non-random mortality in both settings. In captivity, the oldest animals showed senescence in their ability to regain lost BM, whereas no evidence of FS was found in the wild. Overall, captive animals lived longer, but a reversed sex bias in lifespan was observed between wild and captive populations. We suggest that even moderately condition-dependent EM may lead to negligible FS in the wild. While high EM may act to reduce the average lifespan, this evolutionary process may be counteracted by the increased fitness of the long-lived, high-quality individuals.},
  language  = {en}
}
@article{LorenzGleichBecketal.2014,
  author    = {Lorenz, Robert C. and Gleich, Tobias and Beck, Anne and Poehland, Lydia and Raufelder, Diana and Sommer, Werner and Rapp, Michael Armin and Kuehn, Simone and Gallinat, J{\"u}rgen},
  title     = {Reward anticipation in the adolescent and aging brain},
  series = {Human brain mapping : a journal devoted to functional neuroanatomy and neuroimaging},
  volume    = {35},
  journal   = {Human brain mapping : a journal devoted to functional neuroanatomy and neuroimaging},
  number    = {10},
  publisher = {Wiley-Blackwell},
  address   = {Hoboken},
  issn      = {1065-9471},
  doi       = {10.1002/hbm.22540},
  pages     = {5153 -- 5165},
  year      = {2014},
  abstract  = {Processing of reward is the basis of adaptive behavior of the human being. Neural correlates of reward processing seem to be influenced by developmental changes from adolescence to late adulthood. The aim of this study is to uncover these neural correlates during a slot machine gambling task across the lifespan. Therefore, we used functional magnetic resonance imaging to investigate 102 volunteers in three different age groups: 34 adolescents, 34 younger adults, and 34 older adults. We focused on the core reward areas ventral striatum (VS) and ventromedial prefrontal cortex (VMPFC), the valence processing associated areas, anterior cingulate cortex (ACC) and insula, as well as information integration associated areas, dorsolateral prefrontal cortex (DLPFC), and inferior parietal lobule (IPL). Results showed that VS and VMPFC were characterized by a hyperactivation in adolescents compared with younger adults. Furthermore, the ACC and insula were characterized by a U-shape pattern (hypoactivation in younger adults compared with adolescents and older adults), whereas the DLPFC and IPL were characterized by a J-shaped form (hyperactivation in older adults compared with younger groups). Furthermore, a functional connectivity analysis revealed an elevated negative functional coupling between the inhibition-related area rIFG and VS in younger adults compared with adolescents. Results indicate that lifespan-related changes during reward anticipation are characterized by different trajectories in different reward network modules and support the hypothesis of an imbalance in maturation of striatal and prefrontal cortex in adolescents. Furthermore, these results suggest compensatory age-specific effects in fronto-parietal regions. Hum Brain Mapp 35:5153-5165, 2014. (c) 2014 Wiley Periodicals, Inc.},
  language  = {en}
}