@article{MassonBambergStrickeretal.2019, author = {Masson, Torsten and Bamberg, Sebastian and Stricker, Michael and Heidenreich, Anna}, title = {"We can help ourselves": does community resilience buffer against the negative impact of flooding on mental health?}, series = {Natural hazards and earth system sciences}, volume = {19}, journal = {Natural hazards and earth system sciences}, number = {11}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1561-8633}, doi = {10.5194/nhess-19-2371-2019}, pages = {2371 -- 2384}, year = {2019}, abstract = {Empirical evidence of the relationship between social support and post-disaster mental health provides support for a general beneficial effect of social support (main-effect model; Wheaton, 1985). From a theoretical perspective, a buffering effect of social support on the negative relationship between disaster-related stress and mental health also seems plausible (stress-buffering model; Wheaton, 1985). Previous studies, however, (a) have paid less attention to the buffering effect of social support and (b) have mainly relied on interpersonal support (but not collective-level support such as community resilience) when investigating this issue. This previous work might have underestimated the effect of support on post-disaster mental health. Building on a sample of residents in Germany recently affected by flooding (N = 118), we show that community resilience to flooding (but not general interpersonal social support) buffered against the negative effects of flooding on post-disaster mental health. The results support the stress-buffering model and call for a more detailed look at the relationship between support and resilience and post-disaster adjustment, including collective-level variables.}, language = {en} } @incollection{Thorau2019, author = {Thorau, Christian}, title = {"What ought to be heard" : touristic listening and the guided ear}, series = {The Oxford handbook of music listening in the 19th and 20th centuries}, booktitle = {The Oxford handbook of music listening in the 19th and 20th centuries}, publisher = {Oxford University Press}, address = {New York}, isbn = {978-0-19-046696-1}, pages = {207 -- 227}, year = {2019}, language = {en} } @article{SchwarzenthalJuangSchachneretal.2019, author = {Schwarzenthal, Miriam and Juang, Linda P. and Schachner, Maja Katharina and van de Vijver, Fons J. R.}, title = {"When birds of a different feather flock together" - intercultural socialization in adolescents' friendships}, series = {International Journal of Intercultural Relations}, volume = {72}, journal = {International Journal of Intercultural Relations}, publisher = {Elsevier}, address = {Oxford}, issn = {0147-1767}, doi = {10.1016/j.ijintrel.2019.07.001}, pages = {61 -- 75}, year = {2019}, abstract = {We conclude that intercultural friendships are associated with important skills that are needed in increasingly multicultural societies if students experience and discuss cultural variations in these friendships.}, language = {en} } @incollection{Brendel2019, author = {Brendel, Nina}, title = {(How) do students reflect on sustainability?}, series = {Issues in Teaching and Learning of Education for Sustainability}, booktitle = {Issues in Teaching and Learning of Education for Sustainability}, editor = {Chang, Chew-Hung and Kidman, Gillian and Wi, Andy}, publisher = {Routledge}, address = {Abingdon}, isbn = {978-0-429-45043-3}, doi = {10.4324/9780429450433}, pages = {117 -- 126}, year = {2019}, abstract = {The ability to reflect is considered an essential element of Education for Sustainable Development (ESD) and a key competence for learners and educators in ESD (UNECE Strategy for ESD, 2012). In contrast to its high importance, little is known about how reflective thinking can be identified, influenced or increased in the classroom. Therefore, the objective of this study is to address this need by developing an empirical multi-stage model designed to help educators diagnose different levels of reflective thinking and to identify factors that influence students' reflective thinking about sustainability. Based on a 4-8-week project with grade 10 and 11 students studying sustainability, reflective thinking performance using weblogs as reflective journals was analysed. In addition, qualitative semi-structured interviews were conducted with the teachers to comprehend the learning environment and the personal value they assigned to ESD in their geography class. To determine the levels of reflective thinking achieved by the students, the study built on the work of Dewey (1933) and pre-existing multi-stage models of reflective thinking (Bain, Ballantyne, \& Packer, 1999; Chen, Wei, Wu, \& Uden, 2009). Using a qualitative, iterative data analysis, the study adapted the stage models to be applicable in ESD and found great differences in the students' reflection levels. Furthermore, the study identified eight factors that influence students' reflective thinking about sustainability. The outcomes of this study may be valuable for educators in high school and higher education, who seek to diagnose their students' reflective thinking performance and facilitate reflection about sustainability.}, language = {en} } @article{CarlaUhink2019, author = {Carl{\`a}-Uhink, Filippo}, title = {(Re-)Founding Italy: The Social War, Its Aftermath and the Construction of a Roman-Italic Identity in the Roman Republic}, series = {History in Flux: Journal of the Department of History, Faculty of Humanities, Juraj Dobrila University of Pula}, volume = {1}, journal = {History in Flux: Journal of the Department of History, Faculty of Humanities, Juraj Dobrila University of Pula}, number = {1}, doi = {10.32728/flux.2019.1.1}, pages = {3 -- 19}, year = {2019}, abstract = {The Social War (91-88 BCE) is one of the most significant episodes in Roman history: from this war, in which Rome fought against her Italic allies, emerged the elite that would lead the Republic in the last decades of its existence and that would provide the senatorial aristocracy of the early imperial age. The Italic rebels were defeated militarily, yet they achieved their political aims. As such, this war - and its elaboration and memorialization in Roman cultural memory - provides a very interesting case study about how "victory" and "defeat" are constructed discursively after a disruptive war, and how its narration is "functionalized" for a re-foundation of the civic body.}, language = {en} } @article{WiesnerReinholdBarknowitzFlorianetal.2019, author = {Wiesner-Reinhold, Melanie and Barknowitz, Gitte and Florian, Simone and Mewis, Inga and Schumacher, Fabian and Schreiner, Monika and Glatt, Hansruedi}, title = {1-Methoxy-3-indolylmethyl DNA adducts in six tissues, and blood protein adducts, in mice under pak choi diet: time course and persistence}, series = {Archives of toxicology : official journal of EUROTOX}, volume = {93}, journal = {Archives of toxicology : official journal of EUROTOX}, number = {6}, publisher = {Springer}, address = {Heidelberg}, issn = {0340-5761}, doi = {10.1007/s00204-019-02452-3}, pages = {1515 -- 1527}, year = {2019}, abstract = {We previously showed that purified 1-methoxy-3-indolylmethyl (1-MIM) glucosinolate, a secondary plant metabolite in Brassica species, is mutagenic in various in vitro systems and forms DNA and protein adducts in mouse models. In the present study, we administered 1-MIM glucosinolate in a natural matrix to mice, by feeding a diet containing pak choi powder and extract. Groups of animals were killed after 1, 2, 4 and 8 days of pak choi diet, directly or, in the case of the 8-day treatment, after 0, 8 and 16 days of recovery with pak choi-free diet. DNA adducts [N-2-(1-MIM)-dG, N-6-(1-MIM)-dA] in six tissues, as well as protein adducts [tau N-(1-MIM)-His] in serum albumin (SA) and hemoglobin (Hb) were determined using UPLC-MS/MS with isotopically labeled internal standards. None of the samples from the 12 control animals under standard diet contained any 1-MIM adducts. All groups receiving pak choi diet showed DNA adducts in all six tissues (exception: lung of mice treated for a single day) as well as SA and Hb adducts. During the feeding period, all adduct levels continuously increased until day 8 (in the jejunum until day 4). During the 14-day recovery period, N-2-(1-MIM)-dG in liver, kidney, lung, jejunum, cecum and colon decreased to 52, 41, 59, 11, 7 and 2\%, respectively, of the peak level. The time course of N-6-(1-MIM)-dA was similar. Immunohistochemical analyses indicated that cell turnover is a major mechanism of DNA adduct elimination in the intestine. In the same recovery period, protein adducts decreased more rapidly in SA than in Hb, to 0.7 and 37\%, respectively, of the peak level, consistent with the differential turnover of these proteins. In conclusion, the pak choi diet lead to the formation of high levels of adducts in mice. Cell and protein turnover was a major mechanism of adduct elimination, at least in gut and blood.}, language = {en} } @article{ShainyanSuslovaTranDinhPhienetal.2019, author = {Shainyan, Bagrat A. and Suslova, Elena N. and Tran Dinh Phien, and Shlykov, Sergey A. and Heydenreich, Matthias and Kleinpeter, Erich}, title = {1-Methylthio-1-phenyl-1-silacyclohexane: Synthesis, conformational preferences in gas and solution by GED, NMR and theoretical calculations}, series = {Tetrahedron}, volume = {75}, journal = {Tetrahedron}, number = {46}, publisher = {Elsevier}, address = {Oxford}, issn = {0040-4020}, doi = {10.1016/j.tet.2019.130677}, pages = {9}, year = {2019}, abstract = {1-Methylthio-1-phenyl-1-silacyclohexane 1, the first silacyclohexane with the sulfur atom at silicon, was synthesized and its molecular structure and conformational preferences studied by gas-phase electron diffraction (GED) and low temperature C-13 and Si-29 NMR spectroscopy (LT NMR). Quantum-chemical calculations were carried out both for the isolated species and solvate complexes in gas and in polar medium. The predominance of the 1-MeSaxPheq conformer in gas phase (1-Ph-eq :1-Ph-ax = 55:45, Delta G degrees = 0.13 kcal/mol) determined from GED is consistent with that measured in the freon solution by LT NMR (1-Ph-eq:1-Ph-ax = 65:35, Delta G degrees = 0.12 kcal/mol), the experimentally measured ratios being close to that estimated by quantum chemical calculations at both the DFT and MP2 levels of theory. (C) 2019 Elsevier Ltd. All rights reserved.}, language = {en} } @book{Juchler2019, author = {Juchler, Ingo}, title = {1989 in Berlin}, publisher = {bebra}, address = {Berlin}, isbn = {978-3-8148-0236-7}, pages = {128}, year = {2019}, abstract = {Als Hauptstadt der DDR war Ost-Berlin ein wichtiges Zentrum der Friedlichen Revolution von 1989. Ingo Juchler nimmt die Leserinnen und Leser mit zu den zentralen Schaupl{\"a}tzen der Ereignisse, wobei er den Bogen vom 17. Juni 1953 {\"u}ber die Protestbewegung der 1970er Jahre bis hin zu den Demonstrationen im Herbst 1989 und den Ereignissen rund um den Mauerfall schl{\"a}gt. Informative Texte zu den Hintergr{\"u}nden, zahlreiche Abbildungen und eine {\"U}bersichtskarte machen das Buch zu einem anschaulichen Zeitreisef{\"u}hrer in die j{\"u}ngere deutsche Geschichte.}, language = {de} } @book{Juchler2019, author = {Juchler, Ingo}, title = {1989 in Deutschland}, publisher = {bebra}, address = {Berlin}, isbn = {978-3-89809-158-9}, pages = {128}, year = {2019}, abstract = {Kaum ein Ereignis in der zweiten H{\"a}lfte des 20. Jahrhunderts war so bedeutsam wie die Friedliche Revolution von 1989, mit der die Bev{\"o}lkerung der DDR sich vom SED - Regime befreite. Dieses Buch nimmt die Leserinnen und Leser mit zu den zentralen Schaupl{\"a}tzen der Protestbewegung in Deutschland - in Leipzig, Berlin, Dresden, Chemnitz, Plauen, Rostock, Potsdam, Stendal und an vielen anderen Orten. Informative Texte zu den Hintergr{\"u}nden der Ereignisse und umfangreiches Bildmaterial machen das Buch zu einem anschaulichen Zeitreisef{\"u}hrer in die j{\"u}ngere deutsche Geschichte.}, language = {de} } @article{GholamrezaieScheckWenderothBottetal.2019, author = {Gholamrezaie, Ershad and Scheck-Wenderoth, Magdalena and Bott, Judith and Heidbach, Oliver and Strecker, Manfred}, title = {3-D crustal density model of the Sea of Marmara}, series = {Solid Earth}, volume = {10}, journal = {Solid Earth}, publisher = {Copernicus Publ.}, address = {G{\"o}ttingen}, issn = {1869-9510}, doi = {10.5194/se-10-785-2019}, pages = {785 -- 807}, year = {2019}, abstract = {Abstract. The Sea of Marmara, in northwestern Turkey, is a transition zone where the dextral North Anatolian Fault zone (NAFZ) propagates westward from the Anatolian Plate to the Aegean Sea Plate. The area is of interest in the context of seismic hazard of Istanbul, a metropolitan area with about 15 million inhabitants. Geophysical observations indicate that the crust is heterogeneous beneath the Marmara basin, but a detailed characterization of the crustal heterogeneities is still missing. To assess if and how crustal heterogeneities are related to the NAFZ segmentation below the Sea of Marmara, we develop new crustal-scale 3-D density models which integrate geological and seismological data and that are additionally constrained by 3-D gravity modeling. For the latter, we use two different gravity datasets including global satellite data and local marine gravity observation. Considering the two different datasets and the general non-uniqueness in potential field modeling, we suggest three possible "end-member" solutions that are all consistent with the observed gravity field and illustrate the spectrum of possible solutions. These models indicate that the observed gravitational anomalies originate from significant density heterogeneities within the crust. Two layers of sediments, one syn-kinematic and one pre-kinematic with respect to the Sea of Marmara formation are underlain by a heterogeneous crystalline crust. A felsic upper crystalline crust (average density of 2720 kgm⁻³) and an intermediate to mafic lower crystalline crust (average density of 2890 kgm⁻³) appear to be cross-cut by two large, dome-shaped mafic highdensity bodies (density of 2890 to 3150 kgm⁻³) of considerable thickness above a rather uniform lithospheric mantle (3300 kgm⁻³). The spatial correlation between two major bends of the main Marmara fault and the location of the highdensity bodies suggests that the distribution of lithological heterogeneities within the crust controls the rheological behavior along the NAFZ and, consequently, maybe influences fault segmentation and thus the seismic hazard assessment in the region.}, language = {en} } @article{GuillemoteauSimonHulinetal.2019, author = {Guillemoteau, Julien and Simon, Francois-Xavier and Hulin, Guillaume and Dousteyssier, Bertrand and Dacko, Marion and Tronicke, Jens}, title = {3-D imaging of subsurface magnetic permeability/susceptibility with portable frequency domain electromagnetic sensors for near surface exploration}, series = {Geophysical journal international}, volume = {219}, journal = {Geophysical journal international}, number = {3}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0956-540X}, doi = {10.1093/gji/ggz382}, pages = {1773 -- 1785}, year = {2019}, abstract = {The in-phase response collected by portable loop-loop electromagnetic induction (EMI) sensors operating at low and moderate induction numbers (<= 1) is typically used for sensing the magnetic permeability (or susceptibility) of the subsurface. This is due to the fact that the in-phase response contains a small induction fraction and a preponderant induced magnetization fraction. The magnetization fraction follows the magneto-static equations similarly to the magnetic method but with an active magnetic source. The use of an active source offers the possibility to collect data with several loop-loop configurations, which illuminate the subsurface with different sensitivity patterns. Such multiconfiguration soundings thereby allows the imaging of subsurface magnetic permeability/susceptibility variations through an inversion procedure. This method is not affected by the remnant magnetization and theoretically overcomes the classical depth ambiguity generally encountered with passive geomagnetic data. To invert multiconfiguration in-phase data sets, we propose a novel methodology based on a full-grid 3-D multichannel deconvolution (MCD) procedure. This method allows us to invert large data sets (e.g. consisting of more than a hundred thousand of data points) for a dense voxel-based 3-D model of magnetic susceptibility subject to smoothness constraints. In this study, we first present and discuss synthetic examples of our imaging procedure, which aim at simulating realistic conditions. Finally, we demonstrate the applicability of our method to field data collected across an archaeological site in Auvergne (France) to image the foundations of a Gallo-Roman villa built with basalt rock material. Our synthetic and field data examples demonstrate the potential of the proposed inversion procedure offering new and complementary ways to interpret data sets collected with modern EMI instruments.}, language = {en} } @article{GomezGarciaMeessenScheckWenderothetal.2019, author = {Gomez-Garcia, Angela Maria and Meeßen, Christian and Scheck-Wenderoth, Magdalena and Monsalve, Gaspar and Bott, Judith and Bernhardt, Anne and Bernal, Gladys}, title = {3-D Modeling of Vertical Gravity Gradients and the Delimitation of Tectonic Boundaries: The Caribbean Oceanic Domain as a Case Study}, series = {Geochemistry, geophysics, geosystems}, volume = {20}, journal = {Geochemistry, geophysics, geosystems}, number = {11}, publisher = {American Geophysical Union}, address = {Washington}, issn = {1525-2027}, doi = {10.1029/2019GC008340}, pages = {5371 -- 5393}, year = {2019}, abstract = {Geophysical data acquisition in oceanic domains is challenging, implying measurements with low and/or nonhomogeneous spatial resolution. The evolution of satellite gravimetry and altimetry techniques allows testing 3-D density models of the lithosphere, taking advantage of the high spatial resolution and homogeneous coverage of satellites. However, it is not trivial to discretise the source of the gravity field at different depths. Here, we propose a new method for inferring tectonic boundaries at the crustal level. As a novelty, instead of modeling the gravity anomalies and assuming a flat Earth approximation, we model the vertical gravity gradients (VGG) in spherical coordinates, which are especially sensitive to density contrasts in the upper layers of the Earth. To validate the methodology, the complex oceanic domain of the Caribbean region is studied, which includes different crustal domains with a tectonic history since Late Jurassic time. After defining a lithospheric starting model constrained by up-to-date geophysical data sets, we tested several a-priory density distributions and selected the model with the minimum misfits with respect to the VGG calculated from the EIGEN-6C4 data set. Additionally, the density of the crystalline crust was inferred by inverting the VGG field. Our methodology enabled us not only to refine, confirm, and/or propose tectonic boundaries in the study area but also to identify a new anomalous buoyant body, located in the South Lesser Antilles subduction zone, and high-density bodies along the Greater, Lesser, and Leeward Antilles forearcs.}, language = {en} } @article{IbarraLiuMeessenetal.2019, author = {Ibarra, Federico and Liu, Sibiao and Meeßen, Christian and Prezzi, Claudia Beatriz and Bott, Judith and Scheck-Wenderoth, Magdalena and Sobolev, Stephan Vladimir and Strecker, Manfred}, title = {3D data-derived lithospheric structure of the Central Andes and its implications for deformation: Insights from gravity and geodynamic modelling}, series = {Tectonophysics : international journal of geotectonics and the geology and physics of the interior of the earth}, volume = {766}, journal = {Tectonophysics : international journal of geotectonics and the geology and physics of the interior of the earth}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0040-1951}, doi = {10.1016/j.tecto.2019.06.025}, pages = {453 -- 468}, year = {2019}, abstract = {We present a new three-dimensional density model of the Central Andes characterizing the structure and composition of the lithosphere together with a geodynamic simulation subjected to continental intraplate shortening. The principal aim of this study is to assess the link between heterogeneities in the lithosphere and different deformation patterns and styles along the orogen-foreland system of the Central Andes. First, we performed a 3D integration of new geological and geophysical data with previous models through forward modelling of Bouguer anomalies. Subsequently, a geodynamic model was set-up and parametrized from the previously obtained 3D structure and composition. We do not find a unambigous correlation between the resulting density configuration and terrane boundaries proposed by other authors. Our models reproduce the observed Bouguer anomaly and deformation patterns in the foreland. We find that thin-skinned deformation in the Subandean fold-and thrust belt is controlled by a thick sedimentary layer and coeval underthrusting of thin crust of the foreland beneath the thick crust of the Andean Plateau. In the adjacent thick-skinned deformation province of the inverted Cretaceous extensional Santa Barbara System sedimentary strata are much thinner and crustal thickness transitions from greater values in the Andean to a more reduced thickness in the foreland. Our results show that deformation processes occur where the highest gradients of lithospheric strength are present between the orogen and the foreland, thus suggesting a spatial correlation between deformation and lithospheric strength.}, language = {en} } @article{BrellSeglGuanteretal.2019, author = {Brell, Maximilian and Segl, Karl and Guanter, Luis and Bookhagen, Bodo}, title = {3D hyperspectral point cloud generation}, series = {ISPRS journal of photogrammetry and remote sensing : official publication of the International Society for Photogrammetry and Remote Sensing}, volume = {149}, journal = {ISPRS journal of photogrammetry and remote sensing : official publication of the International Society for Photogrammetry and Remote Sensing}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0924-2716}, doi = {10.1016/j.isprsjprs.2019.01.022}, pages = {200 -- 214}, year = {2019}, abstract = {Remote Sensing technologies allow to map biophysical, biochemical, and earth surface parameters of the land surface. Of especial interest for various applications in environmental and urban sciences is the combination of spectral and 3D elevation information. However, those two data streams are provided separately by different instruments, namely airborne laser scanner (ALS) for elevation and a hyperspectral imager (HSI) for high spectral resolution data. The fusion of ALS and HSI data can thus lead to a single data entity consistently featuring rich structural and spectral information. In this study, we present the application of fusing the first pulse return information from ALS data at a sub-decimeter spatial resolution with the lower-spatial resolution hyperspectral information available from the HSI into a hyperspectral point cloud (HSPC). During the processing, a plausible hyperspectral spectrum is assigned to every first-return ALS point. We show that the complementary implementation of spectral and 3D information at the point-cloud scale improves object-based classification and information extraction schemes. This improvements have great potential for numerous land cover mapping and environmental applications.}, language = {en} } @misc{KubatovaHamannKubatetal.2019, author = {Kubatova, Brankica and Hamann, Wolf-Rainer and Kubat, Jiri and Oskinova, Lida}, title = {3D Monte Carlo Radiative Transfer in Inhomogeneous Massive Star Winds}, series = {Radiative signatures from the cosmos}, volume = {519}, journal = {Radiative signatures from the cosmos}, publisher = {Astronomical soc pacific}, address = {San Fransisco}, isbn = {978-1-58381-925-8}, issn = {1050-3390}, pages = {209 -- 212}, year = {2019}, abstract = {Already for decades it has been known that the winds of massive stars are inhomogeneous (i.e. clumped). To properly model observed spectra of massive star winds it is necessary to incorporate the 3-D nature of clumping into radiative transfer calculations. In this paper we present our full 3-D Monte Carlo radiative transfer code for inhomogeneous expanding stellar winds. We use a set of parameters to describe dense as well as the rarefied wind components. At the same time, we account for non-monotonic velocity fields. We show how the 3-D density and velocity wind inhomogeneities strongly affect the resonance line formation. We also show how wind clumping can solve the discrepancy between P v and H alpha mass-loss rate diagnostics.}, language = {en} } @article{Brechenmacher2019, author = {Brechenmacher, Thomas}, title = {70 Jahre Israel}, series = {Historisch-politische Mitteilungen : Archiv f{\"u}r Christlich-Demokratische Politik}, volume = {26}, journal = {Historisch-politische Mitteilungen : Archiv f{\"u}r Christlich-Demokratische Politik}, publisher = {B{\"o}hlau}, address = {Wien}, isbn = {978-3-412-51847-9}, pages = {5 -- 15}, year = {2019}, abstract = {Schon kurz nach dem Zweiten Weltkrieg wurde die These vertreten, die Shoah sei ein wichtiger, wenn nicht gar entscheidender Faktor f{\"u}r die Gr{\"u}ndung des Staates Israel gewesen. Der Essay arbeitet heraus, dass der nationalsozialistische Judenmord sicherlich eine moralisch-legitimatorische Funktion gehabt hat, ein unmittelbarer kausaler Zusammenhang mit der Staatsgr{\"u}ndung aber nicht nachzuweisen ist.}, language = {de} } @article{ZhangBramskiTutusetal.2019, author = {Zhang, Shuhao and Bramski, Julia and Tutus, Murat and Pietruszka, J{\"o}rg and B{\"o}ker, Alexander and Reinicke, Stefan}, title = {A Biocatalytically Active Membrane Obtained from Immobilization of 2-Deoxy-D-ribose-5-phosphate Aldolase on a Porous Support}, series = {ACS applied materials \& interfaces}, volume = {11}, journal = {ACS applied materials \& interfaces}, number = {37}, publisher = {American Chemical Society}, address = {Washington}, issn = {1944-8244}, doi = {10.1021/acsami.9b12029}, pages = {34441 -- 34453}, year = {2019}, abstract = {Aldol reactions play an important role in organic synthesis, as they belong to the class of highly beneficial C-C-linking reactions. Aldol-type reactions can be efficiently and stereoselectively catalyzed by the enzyme 2-deoxy-D-ribose-5-phosphate aldolase (DERA) to gain key intermediates for pharmaceuticals such as atorvastatin. The immobilization of DERA would open the opportunity for a continuous operation mode which gives access to an efficient, large-scale production of respective organic intermediates. In this contribution, we synthesize and utilize DERA/polymer conjugates for the generation and fixation of a DERA bearing thin film on a polymeric membrane support. The conjugation strongly increases the tolerance of the enzyme toward the industrial relevant substrate acetaldehyde while UV-cross-linkable groups along the conjugated polymer chains provide the opportunity for covalent binding to the support. First, we provide a thorough characterization of the conjugates followed by immobilization tests on representative, nonporous cycloolefinic copolymer supports. Finally, immobilization on the target supports constituted of polyacrylonitrile (PAN) membranes is performed, and the resulting enzymatically active membranes are implemented in a simple membrane module setup for the first assessment of biocatalytic performance in the continuous operation mode using the combination hexanal/acetaldehyde as the substrate.}, language = {en} } @article{WuttkeLiLietal.2019, author = {Wuttke, Matthias and Li, Yong and Li, Man and Sieber, Karsten B. and Feitosa, Mary F. and Gorski, Mathias and Tin, Adrienne and Wang, Lihua and Chu, Audrey Y. and Hoppmann, Anselm and Kirsten, Holger and Giri, Ayush and Chai, Jin-Fang and Sveinbjornsson, Gardar and Tayo, Bamidele O. and Nutile, Teresa and Fuchsberger, Christian and Marten, Jonathan and Cocca, Massimiliano and Ghasemi, Sahar and Xu, Yizhe and Horn, Katrin and Noce, Damia and Van der Most, Peter J. and Sedaghat, Sanaz and Yu, Zhi and Akiyama, Masato and Afaq, Saima and Ahluwalia, Tarunveer Singh and Almgren, Peter and Amin, Najaf and Arnlov, Johan and Bakker, Stephan J. L. and Bansal, Nisha and Baptista, Daniela and Bergmann, Sven and Biggs, Mary L. and Biino, Ginevra and Boehnke, Michael and Boerwinkle, Eric and Boissel, Mathilde and B{\"o}ttinger, Erwin and Boutin, Thibaud S. and Brenner, Hermann and Brumat, Marco and Burkhardt, Ralph and Butterworth, Adam S. and Campana, Eric and Campbell, Archie and Campbell, Harry and Canouil, Mickael and Carroll, Robert J. and Catamo, Eulalia and Chambers, John C. and Chee, Miao-Ling and Chee, Miao-Li and Chen, Xu and Cheng, Ching-Yu and Cheng, Yurong and Christensen, Kaare and Cifkova, Renata and Ciullo, Marina and Concas, Maria Pina and Cook, James P. and Coresh, Josef and Corre, Tanguy and Sala, Cinzia Felicita and Cusi, Daniele and Danesh, John and Daw, E. Warwick and De Borst, Martin H. and De Grandi, Alessandro and De Mutsert, Renee and De Vries, Aiko P. J. and Degenhardt, Frauke and Delgado, Graciela and Demirkan, Ayse and Di Angelantonio, Emanuele and Dittrich, Katalin and Divers, Jasmin and Dorajoo, Rajkumar and Eckardt, Kai-Uwe and Ehret, Georg and Elliott, Paul and Endlich, Karlhans and Evans, Michele K. and Felix, Janine F. and Foo, Valencia Hui Xian and Franco, Oscar H. and Franke, Andre and Freedman, Barry I. and Freitag-Wolf, Sandra and Friedlander, Yechiel and Froguel, Philippe and Gansevoort, Ron T. and Gao, He and Gasparini, Paolo and Gaziano, J. Michael and Giedraitis, Vilmantas and Gieger, Christian and Girotto, Giorgia and Giulianini, Franco and Gogele, Martin and Gordon, Scott D. and Gudbjartsson, Daniel F. and Gudnason, Vilmundur and Haller, Toomas and Hamet, Pavel and Harris, Tamara B. and Hartman, Catharina A. and Hayward, Caroline and Hellwege, Jacklyn N. and Heng, Chew-Kiat and Hicks, Andrew A. and Hofer, Edith and Huang, Wei and Hutri-Kahonen, Nina and Hwang, Shih-Jen and Ikram, M. Arfan and Indridason, Olafur S. and Ingelsson, Erik and Ising, Marcus and Jaddoe, Vincent W. V. and Jakobsdottir, Johanna and Jonas, Jost B. and Joshi, Peter K. and Josyula, Navya Shilpa and Jung, Bettina and Kahonen, Mika and Kamatani, Yoichiro and Kammerer, Candace M. and Kanai, Masahiro and Kastarinen, Mika and Kerr, Shona M. and Khor, Chiea-Chuen and Kiess, Wieland and Kleber, Marcus E. and Koenig, Wolfgang and Kooner, Jaspal S. and Korner, Antje and Kovacs, Peter and Kraja, Aldi T. and Krajcoviechova, Alena and Kramer, Holly and Kramer, Bernhard K. and Kronenberg, Florian and Kubo, Michiaki and Kuhnel, Brigitte and Kuokkanen, Mikko and Kuusisto, Johanna and La Bianca, Martina and Laakso, Markku and Lange, Leslie A. and Langefeld, Carl D. and Lee, Jeannette Jen-Mai and Lehne, Benjamin and Lehtimaki, Terho and Lieb, Wolfgang and Lim, Su-Chi and Lind, Lars and Lindgren, Cecilia M. and Liu, Jun and Liu, Jianjun and Loeffler, Markus and Loos, Ruth J. F. and Lucae, Susanne and Lukas, Mary Ann and Lyytikainen, Leo-Pekka and Magi, Reedik and Magnusson, Patrik K. E. and Mahajan, Anubha and Martin, Nicholas G. and Martins, Jade and Marz, Winfried and Mascalzoni, Deborah and Matsuda, Koichi and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Metspalu, Andres and Mikaelsdottir, Evgenia K. and Milaneschi, Yuri and Miliku, Kozeta and Mishra, Pashupati P. and Program, V. A. Million Veteran and Mohlke, Karen L. and Mononen, Nina and Montgomery, Grant W. and Mook-Kanamori, Dennis O. and Mychaleckyj, Josyf C. and Nadkarni, Girish N. and Nalls, Mike A. and Nauck, Matthias and Nikus, Kjell and Ning, Boting and Nolte, Ilja M. and Noordam, Raymond and Olafsson, Isleifur and Oldehinkel, Albertine J. and Orho-Melander, Marju and Ouwehand, Willem H. and Padmanabhan, Sandosh and Palmer, Nicholette D. and Palsson, Runolfur and Penninx, Brenda W. J. H. and Perls, Thomas and Perola, Markus and Pirastu, Mario and Pirastu, Nicola and Pistis, Giorgio and Podgornaia, Anna I. and Polasek, Ozren and Ponte, Belen and Porteous, David J. and Poulain, Tanja and Pramstaller, Peter P. and Preuss, Michael H. and Prins, Bram P. and Province, Michael A. and Rabelink, Ton J. and Raffield, Laura M. and Raitakari, Olli T. and Reilly, Dermot F. and Rettig, Rainer and Rheinberger, Myriam and Rice, Kenneth M. and Ridker, Paul M. and Rivadeneira, Fernando and Rizzi, Federica and Roberts, David J. and Robino, Antonietta and Rossing, Peter and Rudan, Igor and Rueedi, Rico and Ruggiero, Daniela and Ryan, Kathleen A. and Saba, Yasaman and Sabanayagam, Charumathi and Salomaa, Veikko and Salvi, Erika and Saum, Kai-Uwe and Schmidt, Helena and Schmidt, Reinhold and Ben Schottker, and Schulz, Christina-Alexandra and Schupf, Nicole and Shaffer, Christian M. and Shi, Yuan and Smith, Albert V. and Smith, Blair H. and Soranzo, Nicole and Spracklen, Cassandra N. and Strauch, Konstantin and Stringham, Heather M. and Stumvoll, Michael and Svensson, Per O. and Szymczak, Silke and Tai, E-Shyong and Tajuddin, Salman M. and Tan, Nicholas Y. Q. and Taylor, Kent D. and Teren, Andrej and Tham, Yih-Chung and Thiery, Joachim and Thio, Chris H. L. and Thomsen, Hauke and Thorleifsson, Gudmar and Toniolo, Daniela and Tonjes, Anke and Tremblay, Johanne and Tzoulaki, Ioanna and Uitterlinden, Andre G. and Vaccargiu, Simona and Van Dam, Rob M. and Van der Harst, Pim and Van Duijn, Cornelia M. and Edward, Digna R. Velez and Verweij, Niek and Vogelezang, Suzanne and Volker, Uwe and Vollenweider, Peter and Waeber, Gerard and Waldenberger, Melanie and Wallentin, Lars and Wang, Ya Xing and Wang, Chaolong and Waterworth, Dawn M. and Bin Wei, Wen and White, Harvey and Whitfield, John B. and Wild, Sarah H. and Wilson, James F. and Wojczynski, Mary K. and Wong, Charlene and Wong, Tien-Yin and Xu, Liang and Yang, Qiong and Yasuda, Masayuki and Yerges-Armstrong, Laura M. and Zhang, Weihua and Zonderman, Alan B. and Rotter, Jerome I. and Bochud, Murielle and Psaty, Bruce M. and Vitart, Veronique and Wilson, James G. and Dehghan, Abbas and Parsa, Afshin and Chasman, Daniel I. and Ho, Kevin and Morris, Andrew P. and Devuyst, Olivier and Akilesh, Shreeram and Pendergrass, Sarah A. and Sim, Xueling and Boger, Carsten A. and Okada, Yukinori and Edwards, Todd L. and Snieder, Harold and Stefansson, Kari and Hung, Adriana M. and Heid, Iris M. and Scholz, Markus and Teumer, Alexander and Kottgen, Anna and Pattaro, Cristian}, title = {A catalog of genetic loci associated with kidney function from analyses of a million individuals}, series = {Nature genetics}, volume = {51}, journal = {Nature genetics}, number = {6}, publisher = {Nature Publ. Group}, address = {New York}, organization = {Lifelines COHort Study}, issn = {1061-4036}, doi = {10.1038/s41588-019-0407-x}, pages = {957 -- +}, year = {2019}, abstract = {Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.}, language = {en} } @misc{HalfpapSchlosser2019, author = {Halfpap, Stefan and Schlosser, Rainer}, title = {A Comparison of Allocation Algorithms for Partially Replicated Databases}, series = {2019 IEEE 35th International Conference on Data Engineering (ICDE)}, journal = {2019 IEEE 35th International Conference on Data Engineering (ICDE)}, publisher = {IEEE}, address = {New York}, isbn = {978-1-5386-7474-1}, issn = {1084-4627}, doi = {10.1109/ICDE.2019.00226}, pages = {2008 -- 2011}, year = {2019}, abstract = {Increasing demand for analytical processing capabilities can be managed by replication approaches. However, to evenly balance the replicas' workload shares while at the same time minimizing the data replication factor is a highly challenging allocation problem. As optimal solutions are only applicable for small problem instances, effective heuristics are indispensable. In this paper, we test and compare state-of-the-art allocation algorithms for partial replication. By visualizing and exploring their (heuristic) solutions for different benchmark workloads, we are able to derive structural insights and to detect an algorithm's strengths as well as its potential for improvement. Further, our application enables end-to-end evaluations of different allocations to verify their theoretical performance.}, language = {en} } @article{BaroniSchalgeRakovecetal.2019, author = {Baroni, Gabriele and Schalge, Bernd and Rakovec, Oldrich and Kumar, Rohini and Sch{\"u}ler, Lennart and Samaniego, Luis and Simmer, Clemens and Attinger, Sabine}, title = {A Comprehensive Distributed Hydrological Modeling Intercomparison to Support Process Representation and Data Collection Strategies}, series = {Water resources research}, volume = {55}, journal = {Water resources research}, number = {2}, publisher = {American Geophysical Union}, address = {Washington}, issn = {0043-1397}, doi = {10.1029/2018WR023941}, pages = {990 -- 1010}, year = {2019}, abstract = {The improvement of process representations in hydrological models is often only driven by the modelers' knowledge and data availability. We present a comprehensive comparison between two hydrological models of different complexity that is developed to support (1) the understanding of the differences between model structures and (2) the identification of the observations needed for model assessment and improvement. The comparison is conducted on both space and time and by aggregating the outputs at different spatiotemporal scales. In the present study, mHM, a process-based hydrological model, and ParFlow-CLM, an integrated subsurface-surface hydrological model, are used. The models are applied in a mesoscale catchment in Germany. Both models agree in the simulated river discharge at the outlet and the surface soil moisture dynamics, lending their supports for some model applications (drought monitoring). Different model sensitivities are, however, found when comparing evapotranspiration and soil moisture at different soil depths. The analysis supports the need of observations within the catchment for model assessment, but it indicates that different strategies should be considered for the different variables. Evapotranspiration measurements are needed at daily resolution across several locations, while highly resolved spatially distributed observations with lower temporal frequency are required for soil moisture. Finally, the results show the impact of the shallow groundwater system simulated by ParFlow-CLM and the need to account for the related soil moisture redistribution. Our comparison strategy can be applied to other models types and environmental conditions to strengthen the dialog between modelers and experimentalists for improving process representations in Earth system models.}, language = {en} } @article{ChapmanLantOhashietal.2019, author = {Chapman, Eric M. and Lant, Benjamin and Ohashi, Yota and Yu, Bin and Schertzberg, Michael and Go, Christopher and Dogra, Deepika and Koskimaki, Janne and Girard, Romuald and Li, Yan and Fraser, Andrew G. and Awad, Issam A. and Abdelilah-Seyfried, Salim and Gingras, Anne-Claude and Derry, William Brent}, title = {A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis}, series = {Nature Communications}, volume = {10}, journal = {Nature Communications}, publisher = {Nature Publ. Group}, address = {London}, issn = {2041-1723}, doi = {10.1038/s41467-019-09829-z}, pages = {15}, year = {2019}, abstract = {Apoptotic death of cells damaged by genotoxic stress requires regulatory input from surrounding tissues. The C. elegans scaffold protein KRI-1, ortholog of mammalian KRIT1/CCM1, permits DNA damage-induced apoptosis of cells in the germline by an unknown cell non-autonomous mechanism. We reveal that KRI-1 exists in a complex with CCM-2 in the intestine to negatively regulate the ERK-5/MAPK pathway. This allows the KLF-3 transcription factor to facilitate expression of the SLC39 zinc transporter gene zipt-2.3, which functions to sequester zinc in the intestine. Ablation of KRI-1 results in reduced zinc sequestration in the intestine, inhibition of IR-induced MPK-1/ERK1 activation, and apoptosis in the germline. Zinc localization is also perturbed in the vasculature of krit1(-/-) zebrafish, and SLC39 zinc transporters are mis-expressed in Cerebral Cavernous Malformations (CCM) patient tissues. This study provides new insights into the regulation of apoptosis by cross-tissue communication, and suggests a link between zinc localization and CCM disease.}, language = {en} } @article{WinterSchneebergerDungetal.2019, author = {Winter, Benjamin and Schneeberger, Klaus and Dung, N. V. and Huttenlau, M. and Achleitner, S. and St{\"o}tter, J. and Merz, Bruno and Vorogushyn, Sergiy}, title = {A continuous modelling approach for design flood estimation on sub-daily time scale}, series = {Hydrological sciences journal = Journal des sciences hydrologiques}, volume = {64}, journal = {Hydrological sciences journal = Journal des sciences hydrologiques}, number = {5}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0262-6667}, doi = {10.1080/02626667.2019.1593419}, pages = {539 -- 554}, year = {2019}, abstract = {Design flood estimation is an essential part of flood risk assessment. Commonly applied are flood frequency analyses and design storm approaches, while the derived flood frequency using continuous simulation has been getting more attention recently. In this study, a continuous hydrological modelling approach on an hourly time scale, driven by a multi-site weather generator in combination with a -nearest neighbour resampling procedure, based on the method of fragments, is applied. The derived 100-year flood estimates in 16 catchments in Vorarlberg (Austria) are compared to (a) the flood frequency analysis based on observed discharges, and (b) a design storm approach. Besides the peak flows, the corresponding runoff volumes are analysed. The spatial dependence structure of the synthetically generated flood peaks is validated against observations. It can be demonstrated that the continuous modelling approach can achieve plausible results and shows a large variability in runoff volume across the flood events.}, language = {en} } @article{EberliBernoulliVecseietal.2019, author = {Eberli, Gregor P. and Bernoulli, Daniel and Vecsei, Adam and Sekti, Rizky and Grasmueck, Mark and L{\"u}dmann, Thomas and Anselmetti, Flavio S. and Mutti, Maria and Della Porta, Giovanna}, title = {A Cretaceous carbonate delta drift in the Montagna della Maiella, Italy}, series = {Sedimentology : the journal of the International Association of Sedimentologists}, volume = {66}, journal = {Sedimentology : the journal of the International Association of Sedimentologists}, number = {4}, publisher = {Wiley}, address = {Hoboken}, issn = {0037-0746}, doi = {10.1111/sed.12590}, pages = {1266 -- 1301}, year = {2019}, abstract = {The Upper Cretaceous (Campanian-Maastrichtian) bioclastic wedge of the Orfento Formation in the Montagna della Maiella, Italy, is compared to newly discovered contourite drifts in the Maldives. Like the drift deposits in the Maldives, the Orfento Formation fills a channel and builds a Miocene delta-shaped and mounded sedimentary body in the basin that is similar in size to the approximately 350 km(2) large coarse-grained bioclastic Miocene delta drifts in the Maldives. The composition of the bioclastic wedge of the Orfento Formation is also exclusively bioclastic debris sourced from the shallow-water areas and reworked clasts of the Orfento Formation itself. In the near mud-free succession, age-diagnostic fossils are sparse. The depositional textures vary from wackestone to float-rudstone and breccia/conglomerates, but rocks with grainstone and rudstone textures are the most common facies. In the channel, lensoid convex-upward breccias, cross-cutting channelized beds and thick grainstone lobes with abundant scours indicate alternating erosion and deposition from a high-energy current. In the basin, the mounded sedimentary body contains lobes with a divergent progradational geometry. The lobes are built by decametre thick composite megabeds consisting of sigmoidal clinoforms that typically have a channelized topset, a grainy foreset and a fine-grained bottomset with abundant irregular angular clasts. Up to 30 m thick channels filled with intraformational breccias and coarse grainstones pinch out downslope between the megabeds. In the distal portion of the wedge, stacked grainstone beds with foresets and reworked intraclasts document continuous sediment reworking and migration. The bioclastic wedge of the Orfento Formation has been variously interpreted as a succession of sea-level controlled slope deposits, a shoaling shoreface complex, or a carbonate tidal delta. Current-controlled delta drifts in the Maldives, however, offer a new interpretation because of their similarity in architecture and composition. These similarities include: (i) a feeder channel opening into the basin; (ii) an excavation moat at the exit of the channel; (iii) an overall mounded geometry with an apex that is in shallower water depth than the source channel; (iv) progradation of stacked lobes; (v) channels that pinch out in a basinward direction; and (vi) smaller channelized intervals that are arranged in a radial pattern. As a result, the Upper Cretaceous (Campanian-Maastrichtian) bioclastic wedge of the Orfento Formation in the Montagna della Maiella, Italy, is here interpreted as a carbonate delta drift.}, language = {en} } @article{ZechAttingerBellinetal.2019, author = {Zech, Alraune and Attinger, Sabine and Bellin, Alberto and Cvetkovic, Vladimir and Dietrich, Peter and Fiori, Aldo and Teutsch, Georg and Dagan, Gedeon}, title = {A Critical Analysis of Transverse Dispersivity Field Data}, series = {Groundwater : journal of the Association of Ground-Water Scientists and Engineers, a division of the National Ground Water Association}, volume = {57}, journal = {Groundwater : journal of the Association of Ground-Water Scientists and Engineers, a division of the National Ground Water Association}, number = {4}, publisher = {Wiley}, address = {Hoboken}, issn = {0017-467X}, doi = {10.1111/gwat.12838}, pages = {632 -- 639}, year = {2019}, abstract = {Transverse dispersion, or tracer spreading orthogonal to the mean flow direction, which is relevant e.g, for quantifying bio-degradation of contaminant plumes or mixing of reactive solutes, has been studied in the literature less than the longitudinal one. Inferring transverse dispersion coefficients from field experiments is a difficult and error-prone task, requiring a spatial resolution of solute plumes which is not easily achievable in applications. In absence of field data, it is a questionable common practice to set transverse dispersivities as a fraction of the longitudinal one, with the ratio 1/10 being the most prevalent. We collected estimates of field-scale transverse dispersivities from existing publications and explored possible scale relationships as guidance criteria for applications. Our investigation showed that a large number of estimates available in the literature are of low reliability and should be discarded from further analysis. The remaining reliable estimates are formation-specific, span three orders of magnitude and do not show any clear scale-dependence on the plume traveled distance. The ratios with the longitudinal dispersivity are also site specific and vary widely. The reliability of transverse dispersivities depends significantly on the type of field experiment and method of data analysis. In applications where transverse dispersion plays a significant role, inference of transverse dispersivities should be part of site characterization with the transverse dispersivity estimated as an independent parameter rather than related heuristically to longitudinal dispersivity.}, language = {en} } @article{LuetkecosmannFaupelPorstmannetal.2019, author = {Luetkecosmann, Steffi and Faupel, Thomas and Porstmann, Silvia and Porstmann, Tomas and Micheel, Burkhard and Hanack, Katja}, title = {A cross-reactive monoclonal antibody as universal detection antibody in autoantibody diagnostic assays}, series = {Clinica chimica acta}, volume = {499}, journal = {Clinica chimica acta}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0009-8981}, doi = {10.1016/j.cca.2019.09.003}, pages = {87 -- 92}, year = {2019}, abstract = {Diagnostics of Autoimmune Diseases involve screening of patient samples for containing autoantibodies against various antigens. To ensure quality of diagnostic assays a calibrator is needed in each assay system. Different calibrators as recombinant human monoclonal antibodies as well as chimeric antibodies against the autoantigens of interest are described. A less cost-intensive and also more representative possibility covering different targets on the antigens is the utilization of polyclonal sera from other species. Nevertheless, the detection of human autoantibodies as well as the calibration reagent containing antibodies from other species in one assay constitutes a challenge in terms of assay calibration. We therefore developed a cross-reactive monoclonal antibody which binds human as well as rabbit sera with similar affinities in the nanomolar range. We tested our monoclonal antibody S38CD11B12 successfully in the commercial Serazym (R) Anti-Cardiolipin-beta 2-GPI IgG/IgM assay and could thereby prove the eligibility of S38CD11B12 as detection antibody in autoimmune diagnostic assays using rabbit derived sera as reference material.}, language = {en} } @article{DemalHeiseReizetal.2019, author = {Demal, Till Joscha and Heise, Melina and Reiz, Benedikt and Dogra, Deepika and Braenne, Ingrid and Reichenspurner, Hermann and M{\"a}nner, J{\"o}rg and Aherrahrou, Zouhair and Schunkert, Heribert and Erdmann, Jeanette and Abdelilah-Seyfried, Salim}, title = {A familial congenital heart disease with a possible multigenic origin involving a mutation in BMPR1A}, series = {Scientific reports}, volume = {9}, journal = {Scientific reports}, publisher = {Nature Publ. Group}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-019-39648-7}, pages = {12}, year = {2019}, abstract = {The genetics of many congenital heart diseases (CHDs) can only unsatisfactorily be explained by known chromosomal or Mendelian syndromes. Here, we present sequencing data of a family with a potentially multigenic origin of CHD. Twelve of nineteen family members carry a familial mutation [NM_004329.2:c.1328 G > A (p.R443H)] which encodes a predicted deleterious variant of BMPR1A. This mutation co-segregates with a linkage region on chromosome 1 that associates with the emergence of severe CHDs including Ebstein's anomaly, atrioventricular septal defect, and others. We show that the continuous overexpression of the zebrafish homologous mutation bmpr1aap.R438H within endocardium causes a reduced AV valve area, a downregulation of Wnt/ß-catenin signalling at the AV canal, and growth of additional tissue mass in adult zebrafish hearts. This finding opens the possibility of testing genetic interactions between BMPR1A and other candidate genes within linkage region 1 which may provide a first step towards unravelling more complex genetic patterns in cardiovascular disease aetiology.}, language = {en} } @article{EmuoyibofarheAkindeleRonkeetal.2019, author = {Emuoyibofarhe, Justice O. and Akindele, Akinyinka Tosin and Ronke, Babatunde Seyi and Omotosho, Adebayo and Meinel, Christoph}, title = {A Fuzzy Rule-Based Model for Remote Monitoring of Preterm in the Intensive Care Unit of Hospitals}, series = {International Journal of Medical Research \& Health Sciences}, volume = {8}, journal = {International Journal of Medical Research \& Health Sciences}, number = {5}, publisher = {Sumathi}, address = {Trichy}, issn = {2319-5886}, pages = {33 -- 44}, year = {2019}, abstract = {The use of Remote patient monitoring (RPM) systems to monitor critically ill patients in the Intensive Care Unit (ICU) has enabled quality and real-time healthcare management. Fuzzy logic as an approach to designing RPM systems provides a means for encapsulating the subjective decision-making process of medical experts in an algorithm suitable for computer implementation. In this paper, a remote monitoring system for preterm in neonatal ICU incubators is modeled and simulated. The model was designed with 4 input variables (body temperature, heart rate, respiratory rate, and oxygen level saturation), and 1 output variable (action performed represented as ACT). ACT decides whether-an alert is generated or not and also determines the message displayed when a notification is required. ACT classifies the clinical priority of the monitored preterm into 5 different fields: code blue, code red, code yellow, code green, and-code black. The model was simulated using a fuzzy logic toolbox of MATLAB R2015A. About 216 IF_THEN rules were formulated to monitor the inputs data fed into the model. The performance of the model was evaluated using-the confusion matrix to determine the model's accuracy, precision, sensitivity, specificity, and false alarm rate. The-experimental results obtained shows that the fuzzy-based system is capable of producing satisfactory results when used for monitoring and classifying the clinical statuses of neonates in ICU incubators.}, language = {en} } @article{LontsiGarciaJerezCamiloMolinaVillegasetal.2019, author = {Lontsi, Agostiny Marrios and Garcia-Jerez, Antonio and Camilo Molina-Villegas, Juan and Jose Sanchez-Sesma, Francisco and Molkenthin, Christian and Ohrnberger, Matthias and Kr{\"u}ger, Frank and Wang, Rongjiang and Fah, Donat}, title = {A generalized theory for full microtremor horizontal-to-vertical [H/V(z,f)] spectral ratio interpretation in offshore and onshore environments}, series = {Geophysical journal international}, volume = {218}, journal = {Geophysical journal international}, number = {2}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0956-540X}, doi = {10.1093/gji/ggz223}, pages = {1276 -- 1297}, year = {2019}, abstract = {Advances in the field of seismic interferometry have provided a basic theoretical interpretation to the full spectrum of the microtremor horizontal-to-vertical spectral ratio [H/V(f)]. The interpretation has been applied to ambient seismic noise data recorded both at the surface and at depth. The new algorithm, based on the diffuse wavefield assumption, has been used in inversion schemes to estimate seismic wave velocity profiles that are useful input information for engineering and exploration seismology both for earthquake hazard estimation and to characterize surficial sediments. However, until now, the developed algorithms are only suitable for on land environments with no offshore consideration. Here, the microtremor H/V(z, f) modelling is extended for applications to marine sedimentary environments for a 1-D layered medium. The layer propagator matrix formulation is used for the computation of the required Green's functions. Therefore, in the presence of a water layer on top, the propagator matrix for the uppermost layer is defined to account for the properties of the water column. As an application example we analyse eight simple canonical layered earth models. Frequencies ranging from 0.2 to 50 Hz are considered as they cover a broad wavelength interval and aid in practice to investigate subsurface structures in the depth range from a few meters to a few hundreds of meters. Results show a marginal variation of 8 per cent at most for the fundamental frequency when a water layer is present. The water layer leads to variations in H/V peak amplitude of up to 50 per cent atop the solid layers.}, language = {en} } @misc{BeisnerGrossartGasol2019, author = {Beisner, Beatrix E. and Grossart, Hans-Peter and Gasol, Josep M.}, title = {A guide to methods for estimating phago-mixotrophy in nanophytoplankton}, series = {Journal of plankton research}, volume = {41}, journal = {Journal of plankton research}, number = {2}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0142-7873}, doi = {10.1093/plankt/fbz008}, pages = {77 -- 89}, year = {2019}, abstract = {Growing attention to phytoplankton mixotrophy as a trophic strategy has led to significant revisions of traditional pelagic food web models and ecosystem functioning. Although some empirical estimates of mixotrophy do exist, a much broader set of in situ measurements are required to (i) identify which organisms are acting as mixotrophs in real time and to (ii) assess the contribution of their heterotrophy to biogeochemical cycling. Estimates are needed through time and across space to evaluate which environmental conditions or habitats favour mixotrophy: conditions still largely unknown. We review methodologies currently available to plankton ecologists to undertake estimates of plankton mixotrophy, in particular nanophytoplankton phago-mixotrophy. Methods are based largely on fluorescent or isotopic tracers, but also take advantage of genomics to identify phylotypes and function. We also suggest novel methods on the cusp of use for phago-mixotrophy assessment, including single-cell measurements improving our capacity to estimate mixotrophic activity and rates in wild plankton communities down to the single-cell level. Future methods will benefit from advances in nanotechnology, micromanipulation and microscopy combined with stable isotope and genomic methodologies. Improved estimates of mixotrophy will enable more reliable models to predict changes in food web structure and biogeochemical flows in a rapidly changing world.}, language = {en} } @misc{MyachykovFischer2019, author = {Myachykov, Andriy and Fischer, Martin H.}, title = {A hierarchical view of abstractness}, series = {Physics of life reviews}, volume = {29}, journal = {Physics of life reviews}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1571-0645}, doi = {10.1016/j.plrev.2019.04.005}, pages = {161 -- 163}, year = {2019}, language = {en} } @article{JantzenWozniakKappeletal.2019, author = {Jantzen, Friederike and Wozniak, Natalia Joanna and Kappel, Christian and Sicard, Adrien and Lenhard, Michael}, title = {A high‑throughput amplicon‑based method for estimating outcrossing rates}, series = {Plant Methods}, volume = {15}, journal = {Plant Methods}, number = {47}, publisher = {BioMed Central}, address = {London}, issn = {1746-4811}, doi = {10.1186/s13007-019-0433-9}, pages = {14}, year = {2019}, abstract = {Background: The outcrossing rate is a key determinant of the population-genetic structure of species and their long-term evolutionary trajectories. However, determining the outcrossing rate using current methods based on PCRgenotyping individual offspring of focal plants for multiple polymorphic markers is laborious and time-consuming. Results: We have developed an amplicon-based, high-throughput enabled method for estimating the outcrossing rate and have applied this to an example of scented versus non-scented Capsella (Shepherd's Purse) genotypes. Our results show that the method is able to robustly capture differences in outcrossing rates. They also highlight potential biases in the estimates resulting from differential haplotype sharing of the focal plants with the pollen-donor population at individual amplicons. Conclusions: This novel method for estimating outcrossing rates will allow determining this key population-genetic parameter with high-throughput across many genotypes in a population, enabling studies into the genetic determinants of successful pollinator attraction and outcrossing.}, language = {en} } @misc{GonzalezLopezPufahl2019, author = {Gonzalez-Lopez, Fernanda and Pufahl, Luise}, title = {A Landscape for Case Models}, series = {Enterprise, Business-Process and Information Systems Modeling}, volume = {352}, journal = {Enterprise, Business-Process and Information Systems Modeling}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-030-20618-5}, issn = {1865-1348}, doi = {10.1007/978-3-030-20618-5_6}, pages = {87 -- 102}, year = {2019}, abstract = {Case Management is a paradigm to support knowledge-intensive processes. The different approaches developed for modeling these types of processes tend to result in scattered models due to the low abstraction level at which the inherently complex processes are therein represented. Thus, readability and understandability is more challenging than that of traditional process models. By reviewing existing proposals in the field of process overviews and case models, this paper extends a case modeling language - the fragment-based Case Management (fCM) language - with the goal of modeling knowledge-intensive processes from a higher abstraction level - to generate a so-called fCM landscape. This proposal is empirically evaluated via an online experiment. Results indicate that interpreting an fCM landscape might be more effective and efficient than interpreting an informationally equivalent case model.}, language = {en} } @article{SchefflerImmenhauserPourteauetal.2019, author = {Scheffler, Franziska and Immenhauser, Adrian and Pourteau, Amaury and Natalicchio, Marcello and Candan, Osman and Oberh{\"a}nsli, Roland}, title = {A lost Tethyan evaporitic basin}, series = {Sedimentology : the journal of the International Association of Sedimentologists}, volume = {66}, journal = {Sedimentology : the journal of the International Association of Sedimentologists}, number = {7}, publisher = {Wiley}, address = {Hoboken}, issn = {0037-0746}, doi = {10.1111/sed.12606}, pages = {2627 -- 2660}, year = {2019}, abstract = {Ancient evaporite deposits are geological archives of depositional environments characterized by a long-term negative precipitation balance and bear evidence for global ocean element mass balance calculations. Here, Cretaceous selenite pseudomorphs from western Anatolia ('Rosetta Marble') — characterized by their exceptional morphological preservation — and their 'marine' geochemical signatures are described and interpreted in a process-oriented context. These rocks recorded Late Cretaceous high-pressure/low-temperature, subduction-related metamorphism with peak conditions of 1·0 to 1·2 GPa and 300 to 400°C. Metre-scale, rock-forming radiating rods, now present as fibrous calcite marble, clearly point to selenitic gypsum as the precursor mineral. Stratigraphic successions are recorded along a reconstructed proximal to distal transect. The cyclical alternation of selenite beds and radiolarian ribbon-bedded cherts in the distal portions are interpreted as a two type of seawater system. During arid intervals, shallow marine brines cascaded downward into basinal settings and induced precipitation. During more humid times, upwelling-induced radiolarian blooms caused the deposition of radiolarite facies. Interestingly, there is no comparable depositional setting known from the Cenozoic world. Meta-selenite geochemical data (δ13C, δ18O and 87Sr/86Sr) plot within the range of reconstructed middle Cretaceous seawater signatures. Possible sources for the 13C-enriched (mean 2·2 per mille) values include methanogenesis, gas hydrates and cold seep fluid exhalation. Spatially resolved component-specific analysis of a rock slab displays isotopic variances between meta-selenite crystals (mean δ13C 2·2 per mille) and host matrix (mean δ13C 1·3 per mille). The Cretaceous evaporite-pseudomorphs of Anatolia represent a basin wide event coeval with the Aptian evaporites of the Proto-Atlantic and the pseudomorphs share many attributes, including lateral distribution of 600 km and stratigraphic thickness of 1·5 to 2·0 km, with the evaporites formed during the younger Messinian salinity crisis. The Rosetta Marble of Anatolia may represent the best-preserved selenite pseudomorphs worldwide and have a clear potential to act as a template for the study of meta-selenite in deep time.}, language = {en} } @article{SchiroColangeliMueller2019, author = {Schiro, Gabriele and Colangeli, Pierluigi and M{\"u}ller, Marina E. H.}, title = {A Metabarcoding Analysis of the Mycobiome of Wheat Ears Across a Topographically Heterogeneous Field}, series = {Frontiers in microbiology}, volume = {10}, journal = {Frontiers in microbiology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-302X}, doi = {10.3389/fmicb.2019.02095}, pages = {12}, year = {2019}, language = {en} } @article{PornsawadSapsakulBoeckmann2019, author = {Pornsawad, Pornsarp and Sapsakul, Nantawan and B{\"o}ckmann, Christine}, title = {A modified asymptotical regularization of nonlinear ill-posed problems}, series = {Mathematics}, volume = {7}, journal = {Mathematics}, edition = {5}, publisher = {MDPI}, address = {Basel, Schweiz}, issn = {2227-7390}, doi = {10.3390/math7050419}, pages = {19}, year = {2019}, abstract = {In this paper, we investigate the continuous version of modified iterative Runge-Kutta-type methods for nonlinear inverse ill-posed problems proposed in a previous work. The convergence analysis is proved under the tangential cone condition, a modified discrepancy principle, i.e., the stopping time T is a solution of ∥𝐹(𝑥𝛿(𝑇))-𝑦𝛿∥=𝜏𝛿+ for some 𝛿+>𝛿, and an appropriate source condition. We yield the optimal rate of convergence.}, language = {en} } @article{SchwarzenthalJuangSchachneretal.2019, author = {Schwarzenthal, Miriam and Juang, Linda P. and Schachner, Maja Katharina and van de Vijver, Fons J. R.}, title = {A multimodal measure of cultural intelligence for adolescents growing up in culturally diverse societies}, series = {International Journal of Intercultural Relations}, volume = {72}, journal = {International Journal of Intercultural Relations}, publisher = {Elsevier}, address = {Oxford}, issn = {0147-1767}, doi = {10.1016/j.ijintrel.2019.07.007}, pages = {109 -- 121}, year = {2019}, abstract = {Adolescents growing up in culturally diverse societies need to develop intercultural competence. To better understand how to develop intercultural competence we need measures specifically relating to the everyday intercultural experiences of adolescents. However, few measures of intercultural competence are available for this target group. Based on the cultural intelligence (CQ) model (Earley \& Ang, 2003), we developed a measure that combines a self-report questionnaire and situational judgment tests (SJTs). The latter comprise a brief description of intercultural situations, followed by questions asking the adolescents to interpret and provide a reaction to the situations. The reliability, factor structure, measurement equivalence, and validity of the new measure was tested in two samples of adolescents in culturally diverse regions in North Rhine-Westphalia (N = 631, 48\% female, M-a(ge) = 13.69 years, SDage = 1.83) and Berlin (N = 1,335, 48\% female, M-age = 14.69 years, SDage, = 0.74) in Germany. The self-report CQ scale showed good reliability and a four-dimensional factor structure with a higher-order CQ factor. The responses to the SJTs were coded based on a coding manual and the ratings loaded onto one factor. The measurement models showed metric to scalar measurement equivalence across immigrant background, gender, and grade. The CQ factor and the SJT factor were positively correlated with each other, as well as with related constructs such as openness, perspective-taking, and diversity beliefs. We conclude that the new measure offers a reliable and valid method to assess the intercultural competence of adolescents growing up in culturally diverse societies.}, language = {en} } @article{ChaabeneNegraCapranicaetal.2019, author = {Chaabene, Helmi and Negra, Yassine and Capranica, Laura and Prieske, Olaf and Granacher, Urs}, title = {A Needs Analysis of Karate Kumite With Recommendations for Performance Testing and Training}, series = {Strength and conditioning journal}, volume = {41}, journal = {Strength and conditioning journal}, number = {3}, publisher = {Lippincott Williams \& Wilkins}, address = {Philadelphia}, issn = {1524-1602}, doi = {10.1519/SSC.0000000000000445}, pages = {35 -- 46}, year = {2019}, abstract = {An effective training program needs to be customized to the specific demands of the redpective sport. Therefore, it is important to conduct a needs analysis to gain information on the unique characteristics of the sport. The objectives of thes review were (A) to conduct a systematic needs analysis of karate kumite and (B) to provide practical recommendations for sport-specific performance testing and training of karate kumite athletes.}, language = {en} } @article{OzturkMalikCheungetal.2019, author = {Ozturk, Ugur and Malik, Nishant and Cheung, Kevin and Marwan, Norbert and Kurths, J{\"u}rgen}, title = {A network-based comparative study of extreme tropical and frontal storm rainfall over Japan}, series = {Climate dynamics : observational, theoretical and computational research on the climate system}, volume = {53}, journal = {Climate dynamics : observational, theoretical and computational research on the climate system}, number = {1-2}, publisher = {Springer}, address = {New York}, issn = {0930-7575}, doi = {10.1007/s00382-018-4597-1}, pages = {521 -- 532}, year = {2019}, abstract = {Frequent and intense rainfall events demand innovative techniques to better predict the extreme rainfall dynamics. This task requires essentially the assessment of the basic types of atmospheric processes that trigger extreme rainfall, and then to examine the differences between those processes, which may help to identify key patterns to improve predictive algorithms. We employ tools from network theory to compare the spatial features of extreme rainfall over the Japanese archipelago and surrounding areas caused by two atmospheric processes: the Baiu front, which occurs mainly in June and July (JJ), and the tropical storms from August to November (ASON). We infer from complex networks of satellite-derived rainfall data, which are based on the nonlinear correlation measure of event synchronization. We compare the spatial scales involved in both systems and identify different regions which receive rainfall due to the large spatial scale of the Baiu and tropical storm systems. We observed that the spatial scales involved in the Baiu driven rainfall extremes, including the synoptic processes behind the frontal development, are larger than tropical storms, which even have long tracks during extratropical transitions. We further delineate regions of coherent rainfall during the two seasons based on network communities, identifying the horizontal (east-west) rainfall bands during JJ over the Japanese archipelago, while during ASON these bands align with the island arc of Japan.}, language = {en} } @article{RheinwahltGoswamiBookhagen2019, author = {Rheinwahlt, Aljoscha and Goswami, Bedartha and Bookhagen, Bodo}, title = {A network-based flow accumulation algorithm for point clouds}, series = {Journal of geophysical research : Earth surface}, volume = {124}, journal = {Journal of geophysical research : Earth surface}, number = {7}, publisher = {American Geophysical Union}, address = {Washington}, issn = {2169-9003}, doi = {10.1029/2018JF004827}, pages = {2013 -- 2033}, year = {2019}, abstract = {Flow accumulation algorithms estimate the steady state of flow on real or modeled topographic surfaces and are crucial for hydrological and geomorphological assessments, including delineation of river networks, drainage basins, and sediment transport processes. Existing flow accumulation algorithms are typically designed to compute flows on regular grids and are not directly applicable to arbitrarily sampled topographic data such as lidar point clouds. In this study we present a random sampling scheme that generates homogeneous point densities, in combination with a novel flow path tracing approach-the Facet-Flow Network (FFN)-that estimates flow accumulation in terms of specific catchment area (SCA) on triangulated surfaces. The random sampling minimizes biases due to spatial sampling and the FFN allows for direct flow estimation from point clouds. We validate our approach on a Gaussian hill surface and study the convergence of its SCA compared to the analytical solution. Here, our algorithm outperforms the multiple flow direction algorithm, which is optimized for divergent surfaces. We also compute the SCA of a 6-km(2)-steep, vegetated catchment on Santa Cruz Island, California, based on airborne lidar point-cloud data. Point-cloud-based SCA values estimated by our method compare well with those estimated by the D-infinity or multiple flow direction algorithm on gridded data. The advantage of computing SCA from point clouds becomes relevant especially for divergent topography and for small drainage areas: These are depicted with much more detail due to the higher sampling density of point clouds.}, language = {en} } @misc{AwasthiKaminskiRappetal.2019, author = {Awasthi, Swapnil and Kaminski, Jakob and Rapp, Michael Armin and Schlagenhauf, Florian and Walter, Henrik and Ruggeri, Barbara and Ripke, Stephan and Schumann, Gunter and Heinz, Andreas}, title = {A neural signature of malleability}, series = {European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology}, volume = {29}, journal = {European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0924-977X}, doi = {10.1016/j.euroneuro.2017.08.139}, pages = {S858 -- S859}, year = {2019}, abstract = {General intelligence has a substantial genetic background in children, adolescents, and adults, but environmental factors also strongly correlate with cognitive performance as evidenced by a strong (up to one SD) increase in average intelligence test results in the second half of the previous century. This change occurred in a period apparently too short to accommodate radical genetic changes. It is highly suggestive that environmental factors interact with genotype by possible modification of epigenetic factors that regulate gene expression and thus contribute to individual malleability. This modification might as well be reflected in recent observations of an association between dopamine-dependent encoding of reward prediction errors and cognitive capacity, which was modulated by adverse life events.}, language = {en} } @article{SaguTchewonpiHuschekBoenicketal.2019, author = {Sagu Tchewonpi, Sorel and Huschek, Gerd and B{\"o}nick, Josephine and Homann, Thomas and Rawel, Harshadrai Manilal}, title = {A New Approach of Extraction of α-Amylase/trypsin Inhibitors from Wheat (Triticum aestivum L.), Based on Optimization Using Plackett-Burman and Box-Behnken Designs}, series = {molecules}, volume = {24}, journal = {molecules}, number = {19}, publisher = {MDPI}, address = {Basel}, issn = {1420-3049}, doi = {10.3390/molecules24193589}, pages = {18}, year = {2019}, abstract = {Wheat is one of the most consumed foods in the world and unfortunately causes allergic reactions which have important health effects. The α-amylase/trypsin inhibitors (ATIs) have been identified as potentially allergen components of wheat. Due to a lack of data on optimization of ATI extraction, a new wheat ATIs extraction approach combining solvent extraction and selective precipitation is proposed in this work. Two types of wheat cultivars (Triticum aestivum L.), Julius and Ponticus were used and parameters such as solvent type, extraction time, temperature, stirring speed, salt type, salt concentration, buffer pH and centrifugation speed were analyzed using the Plackett-Burman design. Salt concentration, extraction time and pH appeared to have significant effects on the recovery of ATIs (p < 0.01). In both wheat cultivars, Julius and Ponticus, ammonium sulfate substantially reduced protein concentration and inhibition of amylase activity (IAA) compared to sodium chloride. The optimal conditions with desirability levels of 0.94 and 0.91 according to the Doehlert design were: salt concentrations of 1.67 and 1.22 M, extraction times of 53 and 118 min, and pHs of 7.1 and 7.9 for Julius and Ponticus, respectively. The corresponding responses were: protein concentrations of 0.31 and 0.35 mg and IAAs of 91.6 and 83.3\%. Electrophoresis and MALDI-TOF/MS analysis showed that the extracted ATIs masses were between 10 and 20 kDa. Based on the initial LC-MS/MS analysis, up to 10 individual ATIs were identified in the extracted proteins under the optimal conditions. The positive implication of the present study lies in the quick assessment of their content in different varieties especially while considering their allergenic potential.}, language = {en} } @article{KellerMuench2019, author = {Keller, Matthias and M{\"u}nch, Florentin}, title = {A new discrete Hopf-Rinow theorem}, series = {Discrete Mathematics}, volume = {342}, journal = {Discrete Mathematics}, number = {9}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0012-365X}, doi = {10.1016/j.disc.2019.03.014}, pages = {2751 -- 2757}, year = {2019}, abstract = {We prove a version of the Hopf-Rinow theorem with respect to path metrics on discrete spaces. The novel aspect is that we do not a priori assume local finiteness but isolate a local finiteness type condition, called essentially locally finite, that is indeed necessary. As a side product we identify the maximal weight, called the geodesic weight, generating the path metric in the situation when the space is complete with respect to any of the equivalent notions of completeness proven in the Hopf-Rinow theorem. As an application we characterize the graphs for which the resistance metric is a path metric induced by the graph structure.}, language = {en} } @article{YuanBraunGueritetal.2019, author = {Yuan, Xiaoping P. and Braun, Jean and Guerit, Laure and Rouby, D. and Cordonnier, G.}, title = {A New Efficient Method to Solve the Stream Power Law Model Taking Into Account Sediment Deposition}, series = {Journal of geophysical research : Earth surface}, volume = {124}, journal = {Journal of geophysical research : Earth surface}, number = {6}, publisher = {American Geophysical Union}, address = {Washington}, issn = {2169-9003}, doi = {10.1029/2018JF004867}, pages = {1346 -- 1365}, year = {2019}, abstract = {The stream power law model has been widely used to represent erosion by rivers but does not take into account the role played by sediment in modulating erosion and deposition rates. Davy and Lague (2009, ) provide an approach to address this issue, but it is computationally demanding because the local balance between erosion and deposition depends on sediment flux resulting from net upstream erosion. Here, we propose an efficient (i.e., O(N) and implicit) method to solve their equation. This means that, unlike other methods used to study the complete dynamics of fluvial systems (e.g., including the transition from detachment-limited to transport-limited behavior), our method is unconditionally stable even when large time steps are used. We demonstrate its applicability by performing a range of simulations based on a simple setup composed of an uplifting region adjacent to a stable foreland basin. As uplift and erosion progress, the mean elevations of the uplifting relief and the foreland increase, together with the average slope in the foreland. Sediments aggrade in the foreland and prograde to reach the base level where sediments are allowed to leave the system. We show how the topography of the uplifting relief and the stratigraphy of the foreland basin are controlled by the efficiency of river erosion and the efficiency of sediment transport by rivers. We observe the formation of a steady-state geometry in the uplifting region, and a dynamic steady state (i.e., autocyclic aggradation and incision) in the foreland, with aggradation and incision thicknesses up to tens of meters.}, language = {en} } @article{ChoiSchmidtTinnefeldetal.2019, author = {Choi, Youngeun and Schmidt, Carsten and Tinnefeld, Philip and Bald, Ilko and R{\"o}diger, Stefan}, title = {A new reporter design based on DNA origami nanostructures for quantification of short oligonucleotides using microbeads}, series = {Scientific Reports}, journal = {Scientific Reports}, number = {9}, publisher = {Macmillan Publishers Limited}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-019-41136-x}, pages = {8}, year = {2019}, abstract = {The DNA origami technique has great potential for the development of brighter and more sensitive reporters for fluorescence based detection schemes such as a microbead-based assay in diagnostic applications. The nanostructures can be programmed to include multiple dye molecules to enhance the measured signal as well as multiple probe strands to increase the binding strength of the target oligonucleotide to these nanostructures. Here we present a proof-of-concept study to quantify short oligonucleotides by developing a novel DNA origami based reporter system, combined with planar microbead assays. Analysis of the assays using the VideoScan digital imaging platform showed DNA origami to be a more suitable reporter candidate for quantification of the target oligonucleotides at lower concentrations than a conventional reporter that consists of one dye molecule attached to a single stranded DNA. Efforts have been made to conduct multiplexed analysis of different targets as well as to enhance fluorescence signals obtained from the reporters. We therefore believe that the quantification of short oligonucleotides that exist in low copy numbers is achieved in a better way with the DNA origami nanostructures as reporters.}, language = {en} } @article{SrokaGodunkoRutschmannetal.2019, author = {Sroka, Pavel and Godunko, Roman J. and Rutschmann, Sereina and Angeli, Kamila B. and Salles, Frederico F. and Gattolliat, Jean-Luc}, title = {A new species of Bungona in Turkey (Ephemeroptera, Baetidae)}, series = {Zoosytematics and evolution}, volume = {95}, journal = {Zoosytematics and evolution}, number = {1}, publisher = {Pensoft Publ.}, address = {Sofia}, issn = {1860-0743}, doi = {10.3897/zse.95.29487}, pages = {1 -- 13}, year = {2019}, abstract = {By using an integrative approach, we describe a new species of mayfly, Bungona (Chopralla) pontica sp. n., from Turkey. The discovery of a representative of the tropical mayfly genus Bungona in the Middle East is rather unexpected. The new species shows all the main morphological characters of the subgenus Chopralla, which has its closest related species occurring in southeastern Asia. Barcoding clearly indicated that the new species represents an independent lineage isolated for a very long time from other members of the complex. The claw is equipped with two rows of three or four flattened denticles. This condition is a unique feature of Bungona (Chopralla) pontica sp. n. among West Palaearctic mayfly species. Within the subgenus Chopralla, the species can be identified by the presence of a simple, not bifid right prostheca (also present only in Bungona (Chopralla) liebenauae (Soldan, Braasch \& Muu, 1987)), the shape of the labial palp, and the absence of protuberances on pronotum.}, language = {en} } @article{Turner2019, author = {Turner, Bryan S.}, title = {A Nineteenth-Century Turning Point}, series = {Regimes of happiness : comparative and historical studies}, journal = {Regimes of happiness : comparative and historical studies}, publisher = {Anthem Press.}, address = {London}, isbn = {978-1-78308-886-7}, pages = {235 -- 248}, year = {2019}, abstract = {Happiness as the ultimate goal of human endeavour is a thread running through theology and philosophy from the ancient Greeks to modern times. Such a claim raises immediately a host of critical objections and problems relating to the idea of cultural relativism. Can the theme of happiness be continuous and how would we know that? One way to overcome this dilemma is to identify 'regimes of happiness' - that is, clusters of ideas, practices and institutions that in one way or another connect to broad ideas of human wellbeing, flourishing and satisfaction or Eudaimonia to use the word that dominates Aristotle's Nicomachean Ethics (Contreras- Vejar and Turner, 2018). Contemporary discussions of happiness almost invariably start with Aristotle (Nagel, 1972). However, the methodology here is to some extent borrowed from Michel Foucault to understand the 'genealogy' of happiness across different social and cultural formations. In the Western world one could identify an Aristotelian regime of happiness based on the idea of a sound polity and flourishing citizens. There is also a Christian regime of happiness around such figures as St. Augustine and within which there have been radical shifts most notably brought about by Luther and the Protestant Reformation. Regimes of happiness can overlap with each other and their borders are obviously fuzzy. Some regimes may last a long time in various forms. For example, Aristotle's treatment of happiness is one of the most cited versions of happiness across the West. The idea of happiness is, however, not confined to the West. For example, the Vietnamese Constitution that was devised by Ho Chi Minh, an admirer of America society, crafted the 1945 Constitution with three key words as its primary values - Independence-freedom-happiness (or niem hanh phuc). The 2013 version of the Constitution in Article 3 says, 'The state guarantees […] that people enjoy what is abundant and free for a happy life with conditions for all- round development.' One further notion behind our discussion of 'regimes of happiness' is that in principle we can detect important shifts in regimes that are associated both with specific networks of individual thinkers, and with institutional changes in the location of intellectuals in these networks. In this chapter I am especially interested in the transitions in thinking about happiness from the late eighteenth century and through the nineteenth century.}, language = {en} } @article{KagelBierFrohmeetal.2019, author = {Kagel, Heike and Bier, Frank Fabian and Frohme, Marcus and Gl{\"o}kler, J{\"o}rn F.}, title = {A Novel Optical Method To Reversibly Control Enzymatic Activity Based On Photoacids}, series = {Scientific reports}, volume = {9}, journal = {Scientific reports}, publisher = {Nature Publishing Group}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-019-50867-w}, pages = {6}, year = {2019}, abstract = {Most biochemical reactions depend on the pH value of the aqueous environment and some are strongly favoured to occur in an acidic environment. A non-invasive control of pH to tightly regulate such reactions with defined start and end points is a highly desirable feature in certain applications, but has proven difficult to achieve so far. We report a novel optical approach to reversibly control a typical biochemical reaction by changing the pH and using acid phosphatase as a model enzyme. The reversible photoacid G-acid functions as a proton donor, changing the pH rapidly and reversibly by using high power UV LEDs as an illumination source in our experimental setup. The reaction can be tightly controlled by simply switching the light on and off and should be applicable to a wide range of other enzymatic reactions, thus enabling miniaturization and parallelization through non-invasive optical means.}, language = {en} } @article{KearneyShemlavanKnippenbergetal.2019, author = {Kearney, Eric and Shemla, Meir and van Knippenberg, Daan and Scholz, Florian A.}, title = {A paradox perspective on the interactive effects of visionary and empowering leadership}, series = {Organizational Behavior and Human Decision Processes}, volume = {155}, journal = {Organizational Behavior and Human Decision Processes}, publisher = {Elsevier}, address = {San Diego}, issn = {0749-5978}, doi = {10.1016/j.obhdp.2019.01.001}, pages = {20 -- 30}, year = {2019}, abstract = {In a multi-source, lagged design field study of 197 leader-follower dyads, we test a model that predicts positive interactive effects of visionary and empowering leadership on follower performance. Based on the paradox perspective, we argue that visionary and empowering leadership are synergistic in that their combination enables leaders to address a key paradox inherent to leader behavior identified by Waldman and Bowen (2016): Maintaining control while simultaneously letting go of control. We argue that visionary leadership addresses the former and empowering leadership addresses the latter pole of this pair of opposites. Hence, in line with paradox thinking, we posit that leaders will engender more positive effects on follower performance when they enact visionary and empowering leadership behaviors simultaneously and adopt a "both-and" approach, rather than focus on one of these behaviors without the other. Our results support our hypothesized interactive effect of visionary and empowering leadership on goal clarity, as well as a conditional indirect effect such that goal clarity mediates the interactive effect of visionary and empowering leadership on individual follower performance.}, language = {en} } @article{BoumaRichterFechner2019, author = {Bouma, Sietske Jeltje Deirdre and Richter, Philipp and Fechner, Cora}, title = {A population of high-velocity absorption-line systems residing in the Local Group}, series = {Astronomy and astrophysics : an international weekly journal}, volume = {627}, journal = {Astronomy and astrophysics : an international weekly journal}, publisher = {EDP Sciences}, address = {Les Ulis}, issn = {1432-0746}, doi = {10.1051/0004-6361/201935078}, pages = {12}, year = {2019}, abstract = {Aims. We investigated the ionisation conditions and distances of Galactic high-velocity clouds (HVCs) in the Galactic halo and beyond in the direction of the Local Group (LG) barycentre and anti-barycentre, by studying spectral data of 29 extragalactic background sources obtained with the Cosmic Origins Spectropgraph (COS) installed on the Hubble Space Telescope (HST). Methods. We model column-densities of low, intermediate, and high ions such as Si ii, C ii, Si iii, Si vi, and C iv, and use these data to construct a set of Cloudy ionisation models. Results. In total, we found 69 high-velocity absorption components along the 29 lines of sight. The components in the direction of the LG barycentre span the entire range of studied velocities, 100 less than or similar to vertical bar nu(LSR)vertical bar less than or similar to 400 km s(-1), while those in the anti-barycentre sample have velocities up to about 300 km s(-1). For 49 components, we infer the gas densities. In the direction of the LG barycentre, the gas densities exhibit a wide range from log nH = -3.96 to -2.55, while in the anti-barycentre direction the densities are systematically higher, log nH > -3.25. The barycentre absorbers can be split into two groups based on their density: a high-density group with log nH > -3.54, which can be affected by the Milky Way radiation field, and a low-density group (log nH <= -3.54). The latter has very low thermal pressures of P/k < 7.3 Kcm(-3). Conclusions. Our study shows that part of the absorbers in the LG barycentre direction trace gas at very low gas densities and thermal pressures. These properties indicate that the absorbers are located beyond the virial radius of the Milky Way. Our study also confirms results from earlier, single-sightline studies, suggesting the presence of a metal-enriched intragroup medium filling the LG near its barycentre.}, language = {en} } @article{Scianna2019, author = {Scianna, Bastian Matteo}, title = {A predisposition to brutality?}, series = {Small wars and insurgencies}, volume = {30}, journal = {Small wars and insurgencies}, number = {4-5}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0959-2318}, doi = {10.1080/09592318.2019.1638551}, pages = {968 -- 993}, year = {2019}, abstract = {The German Sonderweg thesis has been discarded in most research fields. Yet in regards to the military, things differ: all conflicts before the Second World War are interpreted as prelude to the war of extermination between 1939-1945. This article specifically looks at the Franco-Prussian War 1870-71 and German behaviour vis-a-vis regular combatants, civilians and irregular guerrilla fighters, the so-called francs-tireurs. The author argues that the counter-measures were not exceptional for nineteenth century warfare and also shows how selective reading of the existing secondary literature has distorted our view on the war.}, language = {en} } @article{LorenzMatthiasPieperetal.2019, author = {Lorenz, Robert C. and Matthias, Katja and Pieper, Dawid and Wegewitz, Uta Elke and Morche, Johannes and Nocon, Marc and Rissling, Olesja and Schirm, Jaqueline and Jacobs, Anja}, title = {A psychometric study found AMSTAR 2 to be a valid and moderately reliable appraisal tool}, series = {Journal of Clinical Epidemiology}, volume = {114}, journal = {Journal of Clinical Epidemiology}, publisher = {Elsevier}, address = {New York}, issn = {0895-4356}, doi = {10.1016/j.jclinepi.2019.05.028}, pages = {133 -- 140}, year = {2019}, abstract = {Objectives: The objectives of this study were to determine the interrater reliability (IRR) of assessment of multiple systematic reviews (AMSTAR) 2 for reviews of pharmacological or psychological interventions for the treatment of major depression, to compare it to that of AMSTAR and risk of bias in systematic reviews (ROBIS), and to assess the convergent validity between the appraisal tools. Results: The median kappa values as a measure of IRR indicated a moderate agreement for AMSTAR 2 (median = 0.51), a substantial agreement for AMSTAR (median = 0.62), and a fair agreement for ROBIS (median = 0.27). Validity results showed a positive association for AMSTAR and AMSTAR 2 (r = 0.91) as well as ROBIS and AMSTAR 2 (r = 0.84). For the overall rating, AMSTAR 2 showed a high concordance with ROBIS and a lower concordance with AMSTAR. Conclusion: The IRR of AMSTAR 2 was found to be slightly lower than the IRR of AMSTAR and higher than the IRR of ROBIS. Validity measurements indicate that AMSTAR 2 is closely related to both ROBIS and AMSTAR. (C) 2019 Elsevier Inc. All rights reserved.}, language = {en} } @article{HeimannVasyuraBathkeSudhausetal.2019, author = {Heimann, Sebastian and Vasyura-Bathke, Hannes and Sudhaus, Henriette and Isken, Marius Paul and Kriegerowski, Marius and Steinberg, Andreas and Dahm, Torsten}, title = {A Python framework for efficient use of pre-computed Green's functions in seismological and other physical forward and inverse source problems}, series = {Solid earth}, volume = {10}, journal = {Solid earth}, number = {6}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1869-9510}, doi = {10.5194/se-10-1921-2019}, pages = {1921 -- 1935}, year = {2019}, abstract = {The computation of such synthetic GFs is computationally and operationally demanding. As a consequence, the onthe-fly recalculation of synthetic GFs in each iteration of an optimisation is time-consuming and impractical. Therefore, the pre-calculation and efficient storage of synthetic GFs on a dense grid of source to receiver combinations enables the efficient lookup and utilisation of GFs in time-critical scenarios. We present a Python-based framework and toolkit - Pyrocko-GF - that enables the pre-calculation of synthetic GF stores, which are independent of their numerical calculation method and GF transfer function. The framework aids in the creation of such GF stores by interfacing a suite of established numerical forward modelling codes in seismology (computational back ends). So far, interfaces to back ends for layered Earth model cases have been provided; however, the architecture of Pyrocko-GF is designed to cover back ends for other geometries (e.g. full 3-D heterogeneous media) and other physical quantities (e.g. gravity, pressure, tilt). Therefore, Pyrocko-GF defines an extensible GF storage format suitable for a wide range of GF types, especially handling elasticity and wave propagation problems. The framework assists with visualisations, quality control, and the exchange of GF stores, which is supported through an online platform that provides many pre-calculated GF stores for local, regional, and global studies. The Pyrocko-GF toolkit comes with a well-documented application programming interface (API) for the Python programming language to efficiently facilitate forward modelling of geophysical processes, e.g. synthetic waveforms or static displacements for a wide range of source models.}, language = {en} } @inproceedings{GruenerMuehleGayvoronskayaetal.2019, author = {Gr{\"u}ner, Andreas and M{\"u}hle, Alexander and Gayvoronskaya, Tatiana and Meinel, Christoph}, title = {A quantifiable trustmModel for Blockchain-based identity management}, series = {IEEE 2018 International Congress on Cybermatics / 2018 IEEE Conferences on Internet of Things, Green Computing and Communications, cyber, physical and Social Computing, Smart Data, Blockchain, Computer and Information Technology}, booktitle = {IEEE 2018 International Congress on Cybermatics / 2018 IEEE Conferences on Internet of Things, Green Computing and Communications, cyber, physical and Social Computing, Smart Data, Blockchain, Computer and Information Technology}, publisher = {IEEE}, address = {New York}, isbn = {978-1-5386-7975-3}, doi = {10.1109/Cybermatics_2018.2018.00250}, pages = {1475 -- 1482}, year = {2019}, language = {en} } @article{BouaklineFischerSaalfrank2019, author = {Bouakline, Foudhil and Fischer, E. W. and Saalfrank, Peter}, title = {A quantum-mechanical tier model for phonon-driven vibrational relaxation dynamics of adsorbates at surfaces}, series = {The journal of chemical physics : bridges a gap between journals of physics and journals of chemistr}, volume = {150}, journal = {The journal of chemical physics : bridges a gap between journals of physics and journals of chemistr}, number = {24}, publisher = {American Institute of Physics}, address = {Melville}, issn = {0021-9606}, doi = {10.1063/1.5099902}, pages = {14}, year = {2019}, abstract = {We present a quantum-mechanical tier model for vibrational relaxation of low-lying excited states of an adsorbate vibrational mode (system), coupled to surface phonons (bath), at zero temperature. The tier model, widely used in studies of intramolecular vibrational energy redistribution in polyatomics, is adapted here to adsorbate-surface systems with the help of an embedded cluster approach, using orthogonal coordinates for the system and bath modes, and a phononic expansion of their interaction. The key idea of the model is to organize the system-bath zeroth-order vibrational space into a hierarchical structure of vibrational tiers and keep therein only vibrational states that are sequentially generated from the system-bath initial vibrational state. Each tier is generated from the previous one by means of a successor operator, derived from the system-bath interaction Hamiltonian. This sequential procedure leads to a drastic reduction of the dimension of the system-bath vibrational space. We notably show that for harmonic vibrational motion of the system and linear system-bath couplings in the system coordinate, the dimension of the tier-model vibrational basis scales as similar to N-lxv. Here, N is the number of bath modes, l is the highest-order of the phononic expansion, and l is the size of the system vibrational basis. This polynomial scaling is computationally far superior to the exponential scaling of the original zeroth-order vibrational basis, similar to M-N, with M being the number of basis functions per bath mode. In addition, since each tier is coupled only to its adjacent neighbors, the matrix representation of the system-bath Hamiltonian in this new vibrational basis has a symmetric block-tridiagonal form, with each block being very sparse. This favors the combination of the tier-model with iterative Krylov techniques, such as the Lanczos algorithm, to solve the time-dependent Schrodinger equation for the full Hamiltonian. To illustrate the method, we study vibrational relaxation of a D-Si bending mode, coupled via two-and (mainly) one-phonon interactions to a fully D-covered Si(100)-(2 x 1) surface, using a recent first-principles system-bath Hamiltonian. The results of the tier model are compared with those obtained by the Lindblad formalism of the reduced density matrix. We find that the tier model provides much more information and insight into mechanisms of vibration-phonon couplings at surfaces, and gives more reliable estimates of the adsorbate vibrational lifetimes. Moreover, the tier model might also serve as a benchmark for other approximate quantum-dynamics methods, such as multiconfiguration wavefunction approaches. Published under license by AIP Publishing.}, language = {en} } @article{KoppMuellerPohletal.2019, author = {Kopp, Johannes Florian and M{\"u}ller, Sandra Marie and Pohl, Gabriele and Lossow, Kristina and Kipp, Anna Patricia and Schwerdtle, Tanja}, title = {A quick and simple method for the determination of six trace elements in mammalian serum samples using ICP-MS/MS}, series = {Journal of trace elements in medicine and biology}, volume = {54}, journal = {Journal of trace elements in medicine and biology}, publisher = {Elsevier}, address = {M{\"u}nchen}, issn = {0946-672X}, doi = {10.1016/j.jtemb.2019.04.015}, pages = {221 -- 225}, year = {2019}, abstract = {In order to assess the individual trace element status of humans for either medical or scientific purposes, amongst others, blood serum levels are determined. Furthermore, animal models are used to study interactions of trace elements. Most published methods require larger amounts (500-1000 mu L) of serum to achieve a reliable determination of multiple trace elements. However, oftentimes, these amounts of serum cannot be dedicated to a single analysis and the amount available for TE-determination is much lower. Therefore, a published ICP-MS/MS method for trace element determination in serum was miniaturized, optimized and validated for the measurement of Mn, Fe, Cu Zn, I and Se in as little as 50 mu L of human and murine serum and is presented in this work. For validation, recoveries of multiple LOTs and levels from commercially available human reference serum samples were determined, infra- and inter-day variations were assessed and limits of detection and quantification determined. It is shown, that the method is capable of giving accurate and reproducible results for all six elements within the relevant concentration ranges for samples from humans living in central Europe as well as from laboratory mice. As a highlight, the achieved limits of detection and quantification for Mn were found to be at 0.02 mu g/L serum and 0.05 mu g/L serum, respectively, while using an alkaline diluent for the parallel determination of iodine.}, language = {en} } @article{BayonaViverosvonSpechtStraderetal.2019, author = {Bayona Viveros, Jose Antonio and von Specht, Sebastian and Strader, Anne and Hainzl, Sebastian and Cotton, Fabrice Pierre and Schorlemmer, Danijel}, title = {A Regionalized Seismicity Model for Subduction Zones Based on Geodetic Strain Rates, Geomechanical Parameters, and Earthquake-Catalog Data}, series = {Bulletin of the Seismological Society of America}, volume = {109}, journal = {Bulletin of the Seismological Society of America}, number = {5}, publisher = {Seismological Society of America}, address = {Albany}, issn = {0037-1106}, doi = {10.1785/0120190034}, pages = {2036 -- 2049}, year = {2019}, abstract = {The Seismic Hazard Inferred from Tectonics based on the Global Strain Rate Map (SHIFT_GSRM) earthquake forecast was designed to provide high-resolution estimates of global shallow seismicity to be used in seismic hazard assessment. This model combines geodetic strain rates with global earthquake parameters to characterize long-term rates of seismic moment and earthquake activity. Although SHIFT_GSRM properly computes seismicity rates in seismically active continental regions, it underestimates earthquake rates in subduction zones by an average factor of approximately 3. We present a complementary method to SHIFT_GSRM to more accurately forecast earthquake rates in 37 subduction segments, based on the conservation of moment principle and the use of regional interface seismicity parameters, such as subduction dip angles, corner magnitudes, and coupled seismogenic thicknesses. In seven progressive steps, we find that SHIFT_GSRM earthquake-rate underpredictions are mainly due to the utilization of a global probability function of seismic moment release that poorly captures the great variability among subduction megathrust interfaces. Retrospective test results show that the forecast is consistent with the observations during the 1 January 1977 to 31 December 2014 period. Moreover, successful pseudoprospective evaluations for the 1 January 2015 to 31 December 2018 period demonstrate the power of the regionalized earthquake model to properly estimate subduction-zone seismicity.}, language = {en} } @article{SedaghatmehrThirumalaikumarKamranfaretal.2019, author = {Sedaghatmehr, Mastoureh and Thirumalaikumar, Venkatesh P. and Kamranfar, Iman and Marmagne, Anne and Masclaux-Daubresse, Celine and Balazadeh, Salma}, title = {A regulatory role of autophagy for resetting the memory of heat stress in plants}, series = {Plant, cell \& environment : cell physiology, whole-plant physiology, community physiology}, volume = {42}, journal = {Plant, cell \& environment : cell physiology, whole-plant physiology, community physiology}, number = {3}, publisher = {Wiley}, address = {Hoboken}, issn = {0140-7791}, doi = {10.1111/pce.13426}, pages = {1054 -- 1064}, year = {2019}, abstract = {As sessile life forms, plants are repeatedly confronted with adverse environmental conditions, which can impair development, growth, and reproduction. During evolution, plants have established mechanisms to orchestrate the delicate balance between growth and stress tolerance, to reset cellular biochemistry once stress vanishes, or to keep a molecular memory, which enables survival of a harsher stress that may arise later. Although there are several examples of memory in diverse plants species, the molecular machinery underlying the formation, duration, and resetting of stress memories is largely unknown so far. We report here that autophagy, a central self-degradative process, assists in resetting cellular memory of heat stress (HS) in Arabidopsis thaliana. Autophagy is induced by thermopriming (moderate HS) and, intriguingly, remains high long after stress termination. We demonstrate that autophagy mediates the specific degradation of heat shock proteins at later stages of the thermorecovery phase leading to the accumulation of protein aggregates after the second HS and a compromised heat tolerance. Autophagy mutants retain heat shock proteins longer than wild type and concomitantly display improved thermomemory. Our findings reveal a novel regulatory mechanism for HS memory in plants.}, language = {en} } @article{AlbersUestuenWitzeletal.2019, author = {Albers, Philip and {\"U}st{\"u}n, Suayib and Witzel, Katja and Kraner, Max Erdmund and B{\"o}rnke, Frederik}, title = {A Remorin from Nicotiana benthamiana Interacts with the Pseudomonas Type-III Effector Protein HopZ1a and is Phosphorylated by the Immune-Related Kinase PBS1}, series = {Molecular Plant-Microbe Interactions}, volume = {32}, journal = {Molecular Plant-Microbe Interactions}, number = {9}, publisher = {Amer phytopathological SOC}, address = {ST Paul}, issn = {0894-0282}, doi = {10.1094/MPMI-04-19-0105-R}, pages = {1229 -- 1242}, year = {2019}, abstract = {The plasma membrane (PM) is at the interface of plant-pathogen interactions and, thus, many bacterial type-III effector (T3E) proteins target membrane-associated processes to interfere with immunity. The Pseudomonas syringae T3E HopZ1a is a host cell PM-localized effector protein that has several immunity-associated host targets but also activates effector-triggered immunity in resistant backgrounds. Although HopZ1a has been shown to interfere with early defense signaling at the PM, no dedicated PM-associated HopZ1a target protein has been identified until now. Here, we show that HopZ1a interacts with the PM-associated remorin protein NbREM4 from Nicotiana benthamiana in several independent assays. NbREM4 relocalizes to membrane nanodomains after treatment with the bacterial elicitor flg22 and transient overexpression of NbREM4 in N. benthamiana induces the expression of a subset of defense-related genes. We can further show that NbREM4 interacts with the immune-related receptor-like cytoplasmic kinase avrPphB-susceptible 1 (PBS1) and is phosphorylated by PBS1 on several residues in vitro. Thus, we conclude that NbREM4 is associated with early defense signaling at the PM. The possible relevance of the HopZ1a-NbREM4 interaction for HopZ1a virulence and avirulence functions is discussed.}, language = {en} } @article{PingelFayUrbach2019, author = {Pingel, Ruta and Fay, Doris and Urbach, Tina}, title = {A resources perspective on when and how proactive work behaviour leads to employee withdrawal}, series = {Journal of occupational and organizational psychology}, volume = {92}, journal = {Journal of occupational and organizational psychology}, number = {2}, publisher = {Wiley}, address = {Hoboken}, issn = {0963-1798}, doi = {10.1111/joop.12254}, pages = {410 -- 435}, year = {2019}, abstract = {Previous organizational behaviour research has mainly focused on the benefits of proactivity while disregarding its possible drawbacks. The present study examines the ways in which proactive behaviour may foster counterproductive behaviour through increased emotional and cognitive strain. Drawing on conservation of resources theory, we propose that proactive behaviour is a resource-consuming activity that causes irritability and work-related rumination, which, in turn, leads to instrumentally driven employee withdrawal. Further, we hypothesize that external motivation towards proactivity amplifies its strain-eliciting effects. We conducted a longitudinal three-wave questionnaire study (N = 231) and tested hypotheses using an autoregressive, time-lagged model with latent variables. Results showed that when external motivation for proactivity was high, proactivity led to increased irritability and rumination; irritability was, in turn, related to higher levels of withdrawal. The moderated mediation analysis revealed that when external motivation towards proactive behaviour was high, proactive behaviour had an indirect effect on withdrawal behaviour via irritability. The direct effect of proactivity on work-related rumination was in the expected direction, but failed to reach conventional levels of significance (beta = .09, p = .08). Our results indicate that proactivity is not without costs, most clearly if motivated by external reasons.}, language = {en} } @article{SolgerKunzFinketal.2019, author = {Solger, Franziska and Kunz, Tobias C. and Fink, Julian and Paprotka, Kerstin and Pfister, Pauline and Hagen, Franziska and Schumacher, Fabian and Kleuser, Burkhard and Seibel, J{\"u}rgen and Rudel, Thomas}, title = {A role of sphingosine in the intracellular survival of Neisseria gonorrhoeae}, series = {Frontiers in Cellular and Infection Microbiology}, volume = {10}, journal = {Frontiers in Cellular and Infection Microbiology}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {2235-2988}, doi = {10.3389/fcimb.2020.00215}, pages = {12}, year = {2019}, abstract = {Obligate human pathogenic Neisseria gonorrhoeae are the second most frequent bacterial cause of sexually transmitted diseases. These bacteria invade different mucosal tissues and occasionally disseminate into the bloodstream. Invasion into epithelial cells requires the activation of host cell receptors by the formation of ceramide-rich platforms. Here, we investigated the role of sphingosine in the invasion and intracellular survival of gonococci. Sphingosine exhibited an anti-gonococcal activity in vitro. We used specific sphingosine analogs and click chemistry to visualize sphingosine in infected cells. Sphingosine localized to the membrane of intracellular gonococci. Inhibitor studies and the application of a sphingosine derivative indicated that increased sphingosine levels reduced the intracellular survival of gonococci. We demonstrate here, that sphingosine can target intracellular bacteria and may therefore exert a direct bactericidal effect inside cells.}, language = {en} } @article{RojasJimenezRieckWurzbacheretal.2019, author = {Rojas-Jimenez, Keilor and Rieck, Angelika and Wurzbacher, Christian and J{\"u}rgens, Klaus and Labrenz, Matthias and Grossart, Hans-Peter}, title = {A Salinity Threshold Separating Fungal Communities in the Baltic Sea}, series = {Frontiers in Microbiology}, volume = {10}, journal = {Frontiers in Microbiology}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {1664-302X}, doi = {10.3389/fmicb.2019.00680}, pages = {9}, year = {2019}, abstract = {Salinity is a significant factor for structuring microbial communities, but little is known for aquatic fungi, particularly in the pelagic zone of brackish ecosystems. In this study, we explored the diversity and composition of fungal communities following a progressive salinity decline (from 34 to 3 PSU) along three transects of ca. 2000 km in the Baltic Sea, the world's largest estuary. Based on 18S rRNA gene sequence analysis, we detected clear changes in fungal community composition along the salinity gradient and found significant differences in composition of fungal communities established above and below a critical value of 8 PSU. At salinities below this threshold, fungal communities resembled those from freshwater environments, with a greater abundance of Chytridiomycota, particularly of the orders Rhizophydiales, Lobulomycetales, and Gromochytriales. At salinities above 8 PSU, communities were more similar to those from marine environments and, depending on the season, were dominated by a strain of the LKM11 group (Cryptomycota) or by members of Ascomycota and Basidiomycota. Our results highlight salinity as an important environmental driver also for pelagic fungi, and thus should be taken into account to better understand fungal diversity and ecological function in the aquatic realm.}, language = {en} } @article{KucharskiErgintavAhmadetal.2019, author = {Kucharski, Maciej and Ergintav, Arzu and Ahmad, Wael Abdullah and Krstić, Miloš and Ng, Herman Jalli and Kissinger, Dietmar}, title = {A Scalable 79-GHz Radar Platform Based on Single-Channel Transceivers}, series = {IEEE Transactions on Microwave Theory and Techniques}, volume = {67}, journal = {IEEE Transactions on Microwave Theory and Techniques}, number = {9}, publisher = {Inst. of Electr. and Electronics Engineers}, address = {Piscataway}, issn = {0018-9480}, doi = {10.1109/TMTT.2019.2914104}, pages = {3882 -- 3896}, year = {2019}, abstract = {This paper presents a scalable E-band radar platform based on single-channel fully integrated transceivers (TRX) manufactured using 130-nm silicon-germanium (SiGe) BiCMOS technology. The TRX is suitable for flexible radar systems exploiting massive multiple-input-multipleoutput (MIMO) techniques for multidimensional sensing. A fully integrated fractional-N phase-locked loop (PLL) comprising a 39.5-GHz voltage-controlled oscillator is used to generate wideband frequency-modulated continuous-wave (FMCW) chirp for E-band radar front ends. The TRX is equipped with a vector modulator (VM) for high-speed carrier modulation and beam-forming techniques. A single TRX achieves 19.2-dBm maximum output power and 27.5-dB total conversion gain with input-referred 1-dB compression point of -10 dBm. It consumes 220 mA from 3.3-V supply and occupies 3.96 mm(2) silicon area. A two-channel radar platform based on full-custom TRXs and PLL was fabricated to demonstrate high-precision and high-resolution FMCW sensing. The radar enables up to 10-GHz frequency ramp generation in 74-84-GHz range, which results in 1.5-cm spatial resolution. Due to high output power, thus high signal-to-noise ratio (SNR), a ranging precision of 7.5 mu m for a target at 2 m was achieved. The proposed architecture supports scalable multichannel applications for automotive FMCW using a single local oscillator (LO).}, language = {en} } @article{Buerger2019, author = {B{\"u}rger, Gerd}, title = {A seamless filter for daily to seasonal forecasts, with applications to Iran and Brazil}, series = {Quarterly Journal of the Royal Meteorological Society}, volume = {146}, journal = {Quarterly Journal of the Royal Meteorological Society}, number = {726}, publisher = {WILEY-VCH}, address = {Weinheim}, pages = {14}, year = {2019}, abstract = {A digital filter is introduced which treats the problem of predictability versus time averaging in a continuous, seamless manner. This seamless filter (SF) is characterized by a unique smoothing rule that determines the strength of smoothing in dependence on lead time. The rule needs to be specified beforehand, either by expert knowledge or by user demand. As a result, skill curves are obtained that allow a predictability assessment across a whole range of time-scales, from daily to seasonal, in a uniform manner. The SF is applied to downscaled SEAS5 ensemble forecasts for two focus regions in or near the tropical belt, the river basins of the Karun in Iran and the Sao Francisco in Brazil. Both are characterized by strong seasonality and semi-aridity, so that predictability across various time-scales is in high demand. Among other things, it is found that from the start of the water year (autumn), areal precipitation is predictable with good skill for the Karun basin two and a half months ahead; for the Sao Francisco it is only one month, longer-term prediction skill is just above the critical level.}, language = {en} } @article{ArcherBenbowBirdetal.2019, author = {Archer, A. and Benbow, Wystan and Bird, Ralph and Brose, Robert and Buchovecky, M. and Buckley, J. H. and Chromey, A. J. and Cui, Wei and Falcone, A. and Feng, Qi and Finley, J. P. and Fortson, Lucy and Furniss, Amy and Gent, A. and Gueta, O. and Hanna, David and Hassan, T. and Hervet, Olivier and Holder, J. and Hughes, G. and Humensky, T. B. and Johnson, Caitlin A. and Kaaret, Philip and Kar, P. and Kelley-Hoskins, N. and Kertzman, M. and Kieda, David and Krennrich, F. and Kumar, S. and Lang, M. J. and Lin, T. T. Y. and McCann, A. and Moriarty, P. and Mukherjee, Reshmi and Ong, R. A. and Otte, Adam Nepomuk and Pandel, D. and Park, N. and Petrashyk, A. and Pohl, Martin and Pueschel, Elisa and Quinn, J. and Ragan, K. and Richards, Gregory T. and Roache, E. and Sadeh, I and Santander, Marcos and Scott, S. S. and Sembroski, G. H. and Shahinyan, Karlen and Sushch, Iurii and Tyler, J. and Wakely, S. P. and Weinstein, A. and Wells, R. M. and Wilcox, P. and Wilhelm, Alina and Williams, D. A. and Williamson, T. J. and Zitzer, B.}, title = {A Search for Pulsed Very High-energy Gamma-Rays from 13 Young Pulsars in Archival VERITAS Data}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, volume = {876}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, number = {2}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {0004-637X}, doi = {10.3847/1538-4357/ab14f4}, pages = {14}, year = {2019}, abstract = {We conduct a search for periodic emission in the very high-energy (VHE) gamma-ray band (E > 100 GeV) from a total of 13 pulsars in an archival VERITAS data set with a total exposure of over 450 hr. The set of pulsars includes many of the brightest young gamma-ray pulsars visible in the Northern Hemisphere. The data analysis resulted in nondetections of pulsed VHE gamma-rays from each pulsar. Upper limits on a potential VHE gamma-ray flux are derived at the 95\% confidence level above three energy thresholds using two methods. These are the first such searches for pulsed VHE emission from each of the pulsars, and the obtained limits constrain a possible flux component manifesting at VHEs as is seen for the Crab pulsar.}, language = {en} } @article{GailletonMuddClubbetal.2019, author = {Gailleton, Boris and Mudd, Simon M. and Clubb, Fiona J. and Peifer, Daniel and Hurst, Martin D.}, title = {A segmentation approach for the reproducible extraction and quantification of knickpoints from river long profiles}, series = {Earth surface dynamics}, volume = {7}, journal = {Earth surface dynamics}, number = {1}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {2196-6311}, doi = {10.5194/esurf-7-211-2019}, pages = {211 -- 230}, year = {2019}, abstract = {Changes in the steepness of river profiles or abrupt vertical steps (i.e. waterfalls) are thought to be indicative of changes in erosion rates, lithology or other factors that affect landscape evolution. These changes are referred to as knickpoints or knickzones and are pervasive in bedrock river systems. Such features are thought to reveal information about landscape evolution and patterns of erosion, and therefore their locations are often reported in the geomorphic literature. It is imperative that studies reporting knickpoints and knickzones use a reproducible method of quantifying their locations, as their number and spatial distribution play an important role in interpreting tectonically active landscapes. In this contribution we introduce a reproducible knickpoint and knickzone extraction algorithm that uses river profiles transformed by integrating drainage area along channel length (the so-called integral or chi method). The profile is then statistically segmented and the differing slopes and step changes in the elevations of these segments are used to identify knickpoints, knickzones and their relative magnitudes. The output locations of identified knickpoints and knickzones compare favourably with human mapping: we test the method on Santa Cruz Island, CA, using previously reported knickzones and also test the method against a new dataset from the Quadrilatero Ferrifero in Brazil. The algorithm allows for the extraction of varying knickpoint morphologies, including stepped, positive slope-break (concave upward) and negative slope-break knickpoints. We identify parameters that most affect the resulting knickpoint and knickzone locations and provide guidance for both usage and outputs of the method to produce reproducible knickpoint datasets.}, language = {en} } @article{LiebigHenningSarhanetal.2019, author = {Liebig, Ferenc and Henning, Ricky and Sarhan, Radwan Mohamed and Prietzel, Claudia Christina and Schmitt, Clemens Nikolaus Zeno and Bargheer, Matias and Koetz, Joachim}, title = {A simple one-step procedure to synthesise gold nanostars in concentrated aqueous surfactant solutions}, series = {RSC Advances}, volume = {9}, journal = {RSC Advances}, publisher = {RSC Publishing}, address = {London}, issn = {2046-2069}, doi = {10.1039/C9RA02384D}, pages = {23633 -- 23641}, year = {2019}, abstract = {Due to the enhanced electromagnetic field at the tips of metal nanoparticles, the spiked structure of gold nanostars (AuNSs) is promising for surface-enhanced Raman scattering (SERS). Therefore, the challenge is the synthesis of well designed particles with sharp tips. The influence of different surfactants, i.e., dioctyl sodium sulfosuccinate (AOT), sodium dodecyl sulfate (SDS), and benzylhexadecyldimethylammonium chloride (BDAC), as well as the combination of surfactant mixtures on the formation of nanostars in the presence of Ag⁺ ions and ascorbic acid was investigated. By varying the amount of BDAC in mixed micelles the core/spike-shell morphology of the resulting AuNSs can be tuned from small cores to large ones with sharp and large spikes. The concomitant red-shift in the absorption toward the NIR region without losing the SERS enhancement enables their use for biological applications and for time-resolved spectroscopic studies of chemical reactions, which require a permanent supply with a fresh and homogeneous solution. HRTEM micrographs and energy-dispersive X-ray (EDX) experiments allow us to verify the mechanism of nanostar formation according to the silver underpotential deposition on the spike surface in combination with micelle adsorption.}, language = {en} } @article{SchlemmLevermann2019, author = {Schlemm, Tanja and Levermann, Anders}, title = {A simple stress-based cliff-calving law}, series = {The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union}, volume = {13}, journal = {The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union}, number = {9}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1994-0416}, doi = {10.5194/tc-13-2475-2019}, pages = {2475 -- 2488}, year = {2019}, abstract = {Over large coastal regions in Greenland and Antarctica the ice sheet calves directly into the ocean. In contrast to ice-shelf calving, an increase in calving from grounded glaciers contributes directly to sea-level rise. Ice cliffs with a glacier freeboard larger than approximate to 100 m are currently not observed, but it has been shown that such ice cliffs are increasingly unstable with increasing ice thickness. This cliff calving can constitute a self-amplifying ice loss mechanism that may significantly alter sea-level projections both of Greenland and Antarctica. Here we seek to derive a minimalist stress-based parametrization for cliff calving from grounded glaciers whose freeboards exceed the 100m stability limit derived in previous studies. This will be an extension of existing calving laws for tidewater glaciers to higher ice cliffs. To this end we compute the stress field for a glacier with a simplified two-dimensional geometry from the two-dimensional Stokes equation. First we assume a constant yield stress to derive the failure region at the glacier front from the stress field within the glacier. Secondly, we assume a constant response time of ice failure due to exceedance of the yield stress. With this strongly constraining but very simple set of assumptions we propose a cliff-calving law where the calving rate follows a power-law dependence on the freeboard of the ice with exponents between 2 and 3, depending on the relative water depth at the calving front. The critical freeboard below which the ice front is stable decreases with increasing relative water depth of the calving front. For a dry water front it is, for example, 75 m. The purpose of this study is not to provide a comprehensive calving law but to derive a particularly simple equation with a transparent and minimalist set of assumptions.}, language = {en} } @article{PickEffenbergerZhelavskayaetal.2019, author = {Pick, Leonie and Effenberger, Frederic and Zhelavskaya, Irina and Korte, Monika}, title = {A Statistical Classifier for Historical Geomagnetic Storm Drivers Derived Solely From Ground-Based Magnetic Field Measurements}, series = {Earth and Space Science}, volume = {6}, journal = {Earth and Space Science}, publisher = {American Geophysical Union}, address = {Malden, Mass.}, issn = {2333-5084}, doi = {10.1029/2019EA000726}, pages = {2000 -- 2015}, year = {2019}, abstract = {Solar wind observations show that geomagnetic storms are mainly driven by interplanetary coronal mass ejections (ICMEs) and corotating or stream interaction regions (C/SIRs). We present a binary classifier that assigns one of these drivers to 7,546 storms between 1930 and 2015 using ground-based geomagnetic field observations only. The input data consists of the long-term stable Hourly Magnetospheric Currents index alongside the corresponding midlatitude geomagnetic observatory time series. This data set provides comprehensive information on the global storm time magnetic disturbance field, particularly its spatial variability, over eight solar cycles. For the first time, we use this information statistically with regard to an automated storm driver identification. Our supervised classification model significantly outperforms unskilled baseline models (78\% accuracy with 26[19]\% misidentified interplanetary coronal mass ejections [corotating or stream interaction regions]) and delivers plausible driver occurrences with regard to storm intensity and solar cycle phase. Our results can readily be used to advance related studies fundamental to space weather research, for example, studies connecting galactic cosmic ray modulation and geomagnetic disturbances. They are fully reproducible by means of the underlying open-source software (Pick, 2019, http://doi.org/10.5880/GFZ.2.3.2019.003)}, language = {en} } @article{GoettgensHusserKamannetal.2019, author = {G{\"o}ttgens, Fabian and Husser, Tim-Oliver and Kamann, Sebastian and Dreizler, Stefan and Giesers, Benjamin and Kollatschny, Wolfram and Weilbacher, Peter Michael and Roth, Martin M. and Wendt, Martin}, title = {A stellar census in globular clusters with MUSE: A spectral catalogue of emission-line sources}, series = {Astronomy and astrophysics : an international weekly journal}, volume = {631}, journal = {Astronomy and astrophysics : an international weekly journal}, publisher = {EDP Sciences}, address = {Les Ulis}, issn = {0004-6361}, doi = {10.1051/0004-6361/201936485}, pages = {16}, year = {2019}, abstract = {Aims. Globular clusters produce many exotic stars due to a much higher frequency of dynamical interactions in their dense stellar environments. Some of these objects were observed together with several hundred thousand other stars in our MUSE survey of 26 Galactic globular clusters. Assuming that at least a few exotic stars have exotic spectra (i.e. spectra that contain emission lines), we can use this large spectroscopic data set of over a million stellar spectra as a blind survey to detect stellar exotica in globular clusters. Methods. To detect emission lines in each spectrum, we modelled the expected shape of an emission line as a Gaussian curve. This template was used for matched filtering on the di fferences between each observed 1D spectrum and its fitted spectral model. The spectra with the most significant detections of H alpha emission are checked visually and cross-matched with published catalogues. Results. We find 156 stars with H alpha emission, including several known cataclysmic variables (CV) and two new CVs, pulsating variable stars, eclipsing binary stars, the optical counterpart of a known black hole, several probable sub-subgiants and red stragglers, and 21 background emission-line galaxies. We find possible optical counterparts to 39 X-ray sources, as we detected H alpha emission in several spectra of stars that are close to known positions of Chandra X-ray sources. This spectral catalogue can be used to supplement existing or future X-ray or radio observations with spectra of potential optical counterparts to classify the sources.}, language = {en} } @article{GiesersKamannDreizleretal.2019, author = {Giesers, Benjamin David and Kamann, Sebastian and Dreizler, Stefan and Husser, Tim-Oliver and Askar, Abbas and G{\"o}ttgens, Fabian and Brinchmann, Jarle and Latour, Marilyn and Weilbacher, Peter Michael and Wendt, Martin and Roth, Martin M.}, title = {A stellar census in globular clusters with MUSE: Binaries in NGC 3201}, series = {Astronomy and astrophysics : an international weekly journal}, volume = {632}, journal = {Astronomy and astrophysics : an international weekly journal}, publisher = {EDP Sciences}, address = {Les Ulis}, issn = {0004-6361}, doi = {10.1051/0004-6361/201936203}, pages = {20}, year = {2019}, abstract = {We utilise multi-epoch MUSE spectroscopy to study binary stars in the core of the Galactic globular cluster NGC 3201. Our sample consists of 3553 stars with 54 883 spectra in total comprising 3200 main-sequence stars up to 4 magnitudes below the turn-off. Each star in our sample has between 3 and 63 (with a median of 14) reliable radial velocity measurements within five years of observations. We introduce a statistical method to determine the probability of a star showing radial velocity variations based on the whole inhomogeneous radial velocity sample. Using HST photometry and an advanced dynamical MOCCA simulation of this specific cluster we overcome observational biases that previous spectroscopic studies had to deal with. This allows us to infer a binary frequency in the MUSE field of view and enables us to deduce the underlying true binary frequency of (6.75 +/- 0.72)\% in NGC 3201. The comparison of the MUSE observations with the MOCCA simulation suggests a large portion of primordial binaries. We can also confirm a radial increase in the binary fraction towards the cluster centre due to mass segregation. We discovered that in the core of NGC 3201 at least (57.5 +/- 7.9)\% of blue straggler stars are in a binary system. For the first time in a study of globular clusters, we were able to fit Keplerian orbits to a significant sample of 95 binaries. We present the binary system properties of eleven blue straggler stars and the connection to SX Phoenicis-type stars. We show evidence that two blue straggler formation scenarios, the mass transfer in binary (or triple) star systems and the coalescence due to binary-binary interactions, are present in our data. We also describe the binary and spectroscopic properties of four sub-subgiant (or red straggler) stars. Furthermore, we discovered two new black hole candidates with minimum masses (M sin i) of (7.68 +/- 0.50)M-circle dot, (4.4 +/- 2.8)M-circle dot, and refine the minimum mass estimate on the already published black hole to (4.53 +/- 0.21)M-circle dot, These black holes are consistent with an extensive black hole subsystem hosted by NGC 3201.}, language = {en} } @article{LatourHusserGiesersetal.2019, author = {Latour, Marlyn and Husser, Tim Oliver and Giesers, Benjamin David and Kamann, S. and G{\"o}ttgens, Fabian and Dreizler, Stefan and Brinchmann, Jan and Bastian, Nate and Wendt, Martin and Weilbacher, Peter Michael and Molinski, N. S.}, title = {A stellar census in globular clusters with MUSE: multiple populations chemistry in NGC 2808 star star star}, series = {Astronomy and astrophysics : an international weekly journal}, volume = {631}, journal = {Astronomy and astrophysics : an international weekly journal}, publisher = {EDP Sciences}, address = {Les Ulis}, issn = {1432-0746}, doi = {10.1051/0004-6361/201936242}, pages = {14}, year = {2019}, abstract = {Context. Galactic globular clusters (GCs) are now known to host multiple populations displaying particular abundance variations. The different populations within a GC can be well distinguished following their position in the pseudo two-colors diagrams, also referred to as "chromosome maps". These maps are constructed using optical and near-UV photometry available from the Hubble Space Telescope (HST) UV survey of GCs. However, the chemical tagging of the various populations in the chromosome maps is hampered by the fact that HST photometry and elemental abundances are both only available for a limited number of stars. Aims. The spectra collected as part of the MUSE survey of globular clusters provide a spectroscopic counterpart to the HST photometric catalogs covering the central regions of GCs. In this paper, we use the MUSE spectra of 1115 red giant branch (RGB) stars in NGC 2808 to characterize the abundance variations seen in the multiple populations of this cluster. Methods. We used the chromosome map of NGC 2808 to divide the RGB stars into their respective populations. We then combined the spectra of all stars belonging to a given population, resulting in one high signal-to-noise ratio spectrum representative of each population. Results. Variations in the spectral lines of O, Na, Mg, and Al are clearly detected among four of the populations. In order to quantify these variations, we measured equivalent width differences and created synthetic populations spectra that were used to determine abundance variations with respect to the primordial population of the cluster. Our results are in good agreement with the values expected from previous studies based on high-resolution spectroscopy. We do not see any significant variations in the spectral lines of Ca, K, and Ba. We also do not detect abundance variations among the stars belonging to the primordial population of NGC 2808. Conclusions. We demonstrate that in spite of their low resolution, the MUSE spectra can be used to investigate abundance variations in the context of multiple populations.}, language = {en} } @misc{Richly2019, author = {Richly, Keven}, title = {A survey on trajectory data management for hybrid transactional and analytical workloads}, series = {IEEE International Conference on Big Data (Big Data)}, journal = {IEEE International Conference on Big Data (Big Data)}, publisher = {IEEE}, address = {New York}, isbn = {978-1-5386-5035-6}, issn = {2639-1589}, doi = {10.1109/BigData.2018.8622394}, pages = {562 -- 569}, year = {2019}, abstract = {Rapid advances in location-acquisition technologies have led to large amounts of trajectory data. This data is the foundation for a broad spectrum of services driven and improved by trajectory data mining. However, for hybrid transactional and analytical workloads, the storing and processing of rapidly accumulated trajectory data is a non-trivial task. In this paper, we present a detailed survey about state-of-the-art trajectory data management systems. To determine the relevant aspects and requirements for such systems, we developed a trajectory data mining framework, which summarizes the different steps in the trajectory data mining process. Based on the derived requirements, we analyze different concepts to store, compress, index, and process spatio-temporal data. There are various trajectory management systems, which are optimized for scalability, data footprint reduction, elasticity, or query performance. To get a comprehensive overview, we describe and compare different exciting systems. Additionally, the observed similarities in the general structure of different systems are consolidated in a general blueprint of trajectory management systems.}, language = {en} } @article{BalderjahnLeeSeegebarthetal.2019, author = {Balderjahn, Ingo and Lee, Michael S. W. and Seegebarth, Barbara and Peyer, Mathias}, title = {A sustainable pathway to consumer wellbeing}, series = {The Journal of consumer affairs}, volume = {54}, journal = {The Journal of consumer affairs}, number = {2}, publisher = {Wiley}, address = {Malden, Mass.}, issn = {0022-0078}, doi = {10.1111/joca.12278}, pages = {456 -- 488}, year = {2019}, abstract = {This study investigates the effect of different anticonsumption constructs on consumer wellbeing. The study assumes that people will only lower their level of consumption if doing so does not also lower personal wellbeing. More precisely, this research investigates how specific subtypes of sustainable anticonsumption (e.g., voluntary simplicity, collaborative consumption, and debt-free living) relate to different states of consumer's wellbeing (e.g., financial, psychosocial, and subjective wellbeing). This work also examines whether consumer empowerment can improve personal wellbeing and strengthen the anticonsumption wellbeing relationship. The results show that voluntarily foregoing consumption does not reduce wellbeing and consumer empowerment plays a significant role in supporting sustainable pathways to consumer wellbeing. This study reasons that empowerment improves consumer sovereignty, but may be detrimental for consumers heavily concerned about debt-free living. The present investigation concludes by proposing implications for public and consumer policymakers wishing to promote appropriate sustainable (anticonsumption) pathways to consumer wellbeing.}, language = {en} } @article{CordonnierBovyBraun2019, author = {Cordonnier, Guillaume and Bovy, Benoit and Braun, Jean}, title = {A versatile, linear complexity algorithm for flow routing in topographies with depressions}, series = {Earth surface dynamics}, volume = {7}, journal = {Earth surface dynamics}, number = {2}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {2196-6311}, doi = {10.5194/esurf-7-549-2019}, pages = {549 -- 562}, year = {2019}, abstract = {We present a new algorithm for solving the common problem of flow trapped in closed depressions within digital elevation models, as encountered in many applications relying on flow routing. Unlike other approaches (e.g., the Priority-Flood depression filling algorithm), this solution is based on the explicit computation of the flow paths both within and across the depressions through the construction of a graph connecting together all adjacent drainage basins. Although this represents many operations, a linear time complexity can be reached for the whole computation, making it very efficient. Compared to the most optimized solutions proposed so far, we show that this algorithm of flow path enforcement yields the best performance when used in landscape evolution models. In addition to its efficiency, our proposed method also has the advantage of letting the user choose among different strategies of flow path enforcement within the depressions (i.e., filling vs. carving). Furthermore, the computed graph of basins is a generic structure that has the potential to be reused for solving other problems as well, such as the simulation of erosion. This sequential algorithm may be helpful for those who need to, e.g., process digital elevation models of moderate size on single computers or run batches of simulations as part of an inference study.}, language = {en} } @article{AbdallaAdamAharonianetal.2019, author = {Abdalla, Hassan E. and Adam, R. and Aharonian, Felix A. and Benkhali, F. Ait and Ang{\"u}ner, Ekrem Oǧuzhan and Arakawa, M. and Arcaro, C. and Armand, C. and Ashkar, H. and Backes, M. and Martins, V. Barbosa and Barnard, M. and Becherini, Y. and Berge, D. and Bernloehr, K. and Bissaldi, E. and Blackwell, R. and Boettcher, M. and Boisson, C. and Bolmont, J. and Bonnefoy, S. and Bregeon, J. and Breuhaus, M. and Brun, F. and Brun, P. and Bryan, M. and Buechele, M. and Bulik, T. and Bylund, T. and Capasso, M. and Caroff, S. and Carosi, A. and Casanova, Sabrina and Cerruti, M. and Chand, T. and Chandra, S. and Chen, A. and Colafrancesco, S. and Curylo, M. and Davids, I. D. and Deil, C. and Devin, J. and deWilt, P. and Dirson, L. and Djannati-Atai, A. and Dmytriiev, A. and Donath, A. and Doroshenko, V and Dyks, J. and Egberts, Kathrin and Emery, G. and Ernenwein, J-P and Eschbach, S. and Feijen, K. and Fegan, S. and Fiasson, A. and Fontaine, G. and Funk, S. and Fussling, Matthias and Gabici, S. and Gallant, Y. A. and Gate, F. and Giavitto, G. and Giunti, L. and Glawion, D. and Glicenstein, J. F. and Gottschall, D. and Grondin, M-H and Hahn, J. and Haupt, M. and Heinzelmann, G. and Henri, G. and Hermann, G. and Hinton, J. A. and Hofmann, W. and Hoischen, Clemens and Holch, T. L. and Holler, M. and Horns, D. and Huber, D. and Iwasaki, H. and Jamrozy, M. and Jankowsky, D. and Jankowsky, F. and Jardin-Blicq, A. and Jung-Richardt, I and Kastendieck, M. A. and Katarzynski, K. and Katsuragawa, M. and Katz, U. and Khangulyan, D. and Khelifi, B. and King, J. and Klepser, S. and Kluzniak, W. and Komin, Nu and Kosack, K. and Kostunin, D. and Kreter, M. and Lamanna, G. and Lemiere, A. and Lemoine-Goumard, M. and Lenain, J-P and Leser, Eva and Levy, C. and Lohse, T. and Lypova, I and Mackey, J. and Majumdar, J. and Malyshev, D. and Marandon, V and Marcowith, Alexandre and Mares, A. and Mariaud, C. and Marti-Devesa, G. and Marx, R. and Maurin, G. and Meintjes, P. J. and Mitchell, A. M. W. and Moderski, R. and Mohamed, M. and Mohrmann, L. and Moore, C. and Moulin, Emmanuel and Muller, J. and Murach, T. and Nakashima, S. and de Naurois, M. and Ndiyavala, H. and Niederwanger, F. and Niemiec, J. and Oakes, L. and Odaka, H. and Ohm, S. and Wilhelmi, E. de Ona and Ostrowski, M. and Oya, I and Panter, M. and Parsons, R. D. and Perennes, C. and Petrucci, P-O and Peyaud, B. and Piel, Q. and Pita, S. and Poireau, V and Noel, A. Priyana and Prokhorov, D. A. and Prokoph, H. and Puehlhofer, G. and Punch, M. and Quirrenbach, A. and Raab, S. and Rauth, R. and Reimer, A. and Reimer, O. and Remy, Q. and Renaud, M. and Rieger, F. and Rinchiuso, L. and Romoli, C. and Rowell, G. and Rudak, B. and Ruiz-Velasco, E. and Sahakian, V and Sailer, S. and Saito, S. and Sanchez, D. A. and Santangelo, A. and Sasaki, M. and Schlickeiser, R. and Schussler, F. and Schulz, A. and Schutte, H. M. and Schwanke, U. and Schwemmer, S. and Seglar-Arroyo, M. and Senniappan, M. and Seyffert, A. S. and Shafi, N. and Shiningayamwe, K. and Simoni, R. and Sinha, A. and Sol, H. and Specovius, A. and Spir-Jacob, M. and Stawarz, L. and Steenkamp, R. and Stegmann, Christian and Steppa, Constantin Beverly and Takahashi, T. and Tavernier, T. and Taylor, A. M. and Terrier, R. and Tiziani, D. and Tluczykont, M. and Trichard, C. and Tsirou, M. and Tsuji, N. and Tuffs, R. and Uchiyama, Y. and van der Walt, D. J. and van Eldik, C. and van Rensburg, C. and van Soelen, B. and Vasileiadis, G. and Veh, J. and Venter, C. and Vincent, P. and Vink, J. and Voelk, H. J. and Vuillaume, T. and Wadiasingh, Z. and Wagner, S. J. and White, R. and Wierzcholska, A. and Yang, R. and Yoneda, H. and Zacharias, M. and Zanin, R. and Zdziarski, A. A. and Zech, Alraune and Ziegler, A. and Zorn, J. and Zywucka, N. and de Palma, F. and Axelsson, M. and Roberts, O. J.}, title = {A very-high-energy component deep in the gamma-ray burst afterglow}, series = {Nature : the international weekly journal of science}, volume = {575}, journal = {Nature : the international weekly journal of science}, number = {7783}, publisher = {Nature Publ. Group}, address = {London}, issn = {0028-0836}, doi = {10.1038/s41586-019-1743-9}, pages = {464 -- +}, year = {2019}, abstract = {Gamma-ray bursts (GRBs) are brief flashes of gamma-rays and are considered to be the most energetic explosive phenomena in the Universe(1). The emission from GRBs comprises a short (typically tens of seconds) and bright prompt emission, followed by a much longer afterglow phase. During the afterglow phase, the shocked outflow-produced by the interaction between the ejected matter and the circumburst medium-slows down, and a gradual decrease in brightness is observed(2). GRBs typically emit most of their energy via.-rays with energies in the kiloelectronvolt-to-megaelectronvolt range, but a few photons with energies of tens of gigaelectronvolts have been detected by space-based instruments(3). However, the origins of such high-energy (above one gigaelectronvolt) photons and the presence of very-high-energy (more than 100 gigaelectronvolts) emission have remained elusive(4). Here we report observations of very-high-energy emission in the bright GRB 180720B deep in the GRB afterglow-ten hours after the end of the prompt emission phase, when the X-ray flux had already decayed by four orders of magnitude. Two possible explanations exist for the observed radiation: inverse Compton emission and synchrotron emission of ultrarelativistic electrons. Our observations show that the energy fluxes in the X-ray and gamma-ray range and their photon indices remain comparable to each other throughout the afterglow. This discovery places distinct constraints on the GRB environment for both emission mechanisms, with the inverse Compton explanation alleviating the particle energy requirements for the emission observed at late times. The late timing of this detection has consequences for the future observations of GRBs at the highest energies.}, language = {en} } @article{GonzalezFortesTassiTrucchietal.2019, author = {Gonzalez-Fortes, Gloria M. and Tassi, F. and Trucchi, E. and Henneberger, K. and Paijmans, Johanna L. A. and Diez-del-Molino, D. and Schroeder, H. and Susca, R. R. and Barroso-Ruiz, C. and Bermudez, F. J. and Barroso-Medina, C. and Bettencourt, A. M. S. and Sampaio, H. A. and Salas, A. and de Lombera-Hermida, A. and Fabregas Valcarce, Ram{\´o}n and Vaquero, M. and Alonso, S. and Lozano, Marina and Rodriguez-Alvarez, Xose Pedro and Fernandez-Rodriguez, C. and Manica, Andrea and Hofreiter, Michael and Barbujani, Guido}, title = {A western route of prehistoric human migration from Africa into the Iberian Peninsula}, series = {Proceedings of the Royal Society of London : B, Biological sciences}, volume = {286}, journal = {Proceedings of the Royal Society of London : B, Biological sciences}, number = {1895}, publisher = {Royal Society}, address = {London}, issn = {0962-8452}, doi = {10.1098/rspb.2018.2288}, pages = {10}, year = {2019}, abstract = {Being at the western fringe of Europe, Iberia had a peculiar prehistory and a complex pattern of Neolithization. A few studies, all based on modern populations, reported the presence of DNA of likely African origin in this region, generally concluding it was the result of recent gene flow, probably during the Islamic period. Here, we provide evidence of much older gene flow from Africa to Iberia by sequencing whole genomes from four human remains from northern Portugal and southern Spain dated around 4000 years BP (from the Middle Neolithic to the Bronze Age). We found one of them to carry an unequivocal sub-Saharan mitogenome of most probably West or West-Central African origin, to our knowledge never reported before in prehistoric remains outside Africa. Our analyses of ancient nuclear genomes show small but significant levels of sub-Saharan African affinity in several ancient Iberian samples, which indicates that what we detected was not an occasional individual phenomenon, but an admixture event recognizable at the population level. We interpret this result as evidence of an early migration process from Africa into the Iberian Peninsula through a western route, possibly across the Strait of Gibraltar.}, language = {en} } @article{AlkerSchwerdtleSchomburgetal.2019, author = {Alker, Wiebke and Schwerdtle, Tanja and Schomburg, Lutz and Haase, Hajo}, title = {A Zinpyr-1-based Fluorimetric Microassay for Free Zinc in Human Serum}, series = {International journal of molecular sciences}, volume = {20}, journal = {International journal of molecular sciences}, number = {16}, publisher = {MDPI}, address = {Basel}, issn = {1661-6596}, doi = {10.3390/ijms20164006}, pages = {13}, year = {2019}, abstract = {Zinc is an essential trace element, making it crucial to have a reliable biomarker for evaluating an individual's zinc status. The total serum zinc concentration, which is presently the most commonly used biomarker, is not ideal for this purpose, but a superior alternative is still missing. The free zinc concentration, which describes the fraction of zinc that is only loosely bound and easily exchangeable, has been proposed for this purpose, as it reflects the highly bioavailable part of serum zinc. This report presents a fluorescence-based method for determining the free zinc concentration in human serum samples, using the fluorescent probe Zinpyr-1. The assay has been applied on 154 commercially obtained human serum samples. Measured free zinc concentrations ranged from 0.09 to 0.42 nM with a mean of 0.22 ± 0.05 nM. It did not correlate with age or the total serum concentrations of zinc, manganese, iron or selenium. A negative correlation between the concentration of free zinc and total copper has been seen for sera from females. In addition, the free zinc concentration in sera from females (0.21 ± 0.05 nM) was significantly lower than in males (0.23 ± 0.06 nM). The assay uses a sample volume of less than 10 µL, is rapid and cost-effective and allows us to address questions regarding factors influencing the free serum zinc concentration, its connection with the body's zinc status, and its suitability as a future biomarker for an individual's zinc status.}, language = {en} } @article{NorellEckertVanKuikenetal.2019, author = {Norell, Jesper and Eckert, Sebastian and Van Kuiken, Benjamin E. and F{\"o}hlisch, Alexander and Odelius, Michael}, title = {Ab initio simulations of complementary K-edges and solvatization effects for detection of proton transfer in aqueous 2-thiopyridone}, series = {The journal of chemical physics : bridges a gap between journals of physics and journals of chemistr}, volume = {151}, journal = {The journal of chemical physics : bridges a gap between journals of physics and journals of chemistr}, number = {11}, publisher = {American Institute of Physics}, address = {Melville}, issn = {0021-9606}, doi = {10.1063/1.5109840}, pages = {12}, year = {2019}, abstract = {The nitrogen and sulfur K-edge X-ray absorption spectra of aqueous 2-thiopyridone, a model system for excited-state proton transfer in several recent time-resolved measurements, have been simulated from ab initio molecular dynamics. Spectral signatures of the local intra- and inter-molecular structure are identified and rationalized, which facilitates experimental interpretation and optimization. In particular, comparison of aqueous and gas phase spectrum simulations assesses the previously unquantified solvatization effects, where hydrogen bonding is found to yield solvatochromatic shifts up to nearly 1 eV of the main peak positions. Thereby, while each K-edge can still decisively determine the local protonation of its core-excited site, only their combined, complementary fingerprints allow separating all of the three relevant molecular forms, giving a complete picture of the proton transfer.}, language = {en} } @article{CortiCioniFranceschinietal.2019, author = {Corti, Giacomo and Cioni, Raffaello and Franceschini, Zara and Sani, Federico and Scaillet, Stephane and Molin, Paola and Isola, Ilaria and Mazzarini, Francesco and Brune, Sascha and Keir, Derek and Erbello Doelesso, Asfaw and Muluneh, Ameha and Illsley-Kemp, Finnigan and Glerum, Anne}, title = {Aborted propagation of the Ethiopian rift caused by linkage with the Kenyan rift}, series = {Nature Communications}, volume = {10}, journal = {Nature Communications}, publisher = {Nature Publ. Group}, address = {London}, issn = {2041-1723}, doi = {10.1038/s41467-019-09335-2}, pages = {11}, year = {2019}, abstract = {Continental rift systems form by propagation of isolated rift segments that interact, and eventually evolve into continuous zones of deformation. This process impacts many aspects of rifting including rift morphology at breakup, and eventual ocean-ridge segmentation. Yet, rift segment growth and interaction remain enigmatic. Here we present geological data from the poorly documented Ririba rift (South Ethiopia) that reveals how two major sectors of the East African rift, the Kenyan and Ethiopian rifts, interact. We show that the Ririba rift formed from the southward propagation of the Ethiopian rift during the Pliocene but this propagation was short-lived and aborted close to the Pliocene-Pleistocene boundary. Seismicity data support the abandonment of laterally offset, overlapping tips of the Ethiopian and Kenyan rifts. Integration with new numerical models indicates that rift abandonment resulted from progressive focusing of the tectonic and magmatic activity into an oblique, throughgoing rift zone of near pure extension directly connecting the rift sectors.}, language = {en} } @article{BarthaDoeringAlexopoulosGiordanoetal.2019, author = {Bartha-Doering, Lisa and Alexopoulos, Johanna and Giordano, Vito and Stelzer, Lisa and Kainz, Theresa and Benavides-Varela, Silvia and Wartenburger, Isabell and Klebermass-Schrehof, Katrin and Olischar, Monika and Seidl, Rainer Otis and Berger, Angelika}, title = {Absence of neural speech discrimination in preterm infants at term-equivalent age}, series = {Developmental cognitive neuroscience : a journal for cognitive, affective and social developmental neuroscience}, volume = {39}, journal = {Developmental cognitive neuroscience : a journal for cognitive, affective and social developmental neuroscience}, publisher = {Elsevier}, address = {Oxford}, issn = {1878-9293}, doi = {10.1016/j.dcn.2019.100679}, pages = {8}, year = {2019}, abstract = {Children born preterm are at higher risk to develop language deficits. Auditory speech discrimination deficits may be early signs for language developmental problems. The present study used functional near-infrared spectroscopy to investigate neural speech discrimination in 15 preterm infants at term-equivalent age compared to 15 full term neonates. The full term group revealed a significantly greater hemodynamic response to forward compared to backward speech within the left hemisphere extending from superior temporal to inferior parietal and middle and inferior frontal areas. In contrast, the preterm group did not show differences in their hemodynamic responses during forward versus backward speech, thus, they did not discriminate speech from nonspeech. Groups differed significantly in their responses to forward speech, whereas they did not differ in their responses to backward speech. The significant differences between groups point to an altered development of the functional network underlying language acquisition in preterm infants as early as in term-equivalent age.}, language = {en} } @article{EdlundGrisicSteenholdtetal.2019, author = {Edlund, Helena and Grisic, Ana-Marija and Steenholdt, Casper and Ainsworth, Mark Andrew and Brynskov, Torn and Huisinga, Wilhelm and Kloft, Charlotte}, title = {Absence of Relationship Between Crohn's Disease Activity Index or C-Reactive Protein and Infliximab Exposure Calls for Objective Crohn's Disease Activity Measures for the Evaluation of Treatment Effects at Treatment Failure}, series = {Therapeutic drug monitoring : official journal of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology}, volume = {41}, journal = {Therapeutic drug monitoring : official journal of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology}, number = {2}, publisher = {Lippincott Williams \& Wilkins}, address = {Philadelphia}, issn = {0163-4356}, doi = {10.1097/FTD.0000000000000590}, pages = {235 -- 242}, year = {2019}, abstract = {Background: Circulating infliximab (IFX) concentrations correlate with clinical outcomes, forming the basis of the IFX concentration monitoring in patients with Crohn's disease. This study aims to investigate and refine the exposure-response relationship by linking the disease activity markers "Crohn's disease activity index" (CDAI) and C-reactive protein (CRP) to IFX exposure. In addition, we aim to explore the correlations between different disease markers and exposure metrics. Methods: Data from 47 Crohn's disease patients of a randomized controlled trial were analyzed post hoc. All patients had secondary treatment failure at inclusion and had received intensified IFX of 5 mg/kg every 4 weeks for up to 20 weeks. Graphical analyses were performed to explore exposure-response relationships. Metrics of exposure included area under the concentration-time curve (AUC) and trough concentrations (Cmin). Disease activity was measured by CDAI and CRP values, their change from baseline/last visit, and response/remission outcomes at week 12. Results: Although trends toward lower Cmin and lower AUC in nonresponders were observed, neither CDAI nor CRP showed consistent trends of lower disease activity with higher IFX exposure across the 30 evaluated relationships. As can be expected, Cmin and AUC were strongly correlated with each other. Contrarily, the disease activity markers were only weakly correlated with each other. Conclusions: No significant relationship between disease activity, as evaluated by CDAI or CRP, and IFX exposure was identified. AUC did not add benefit compared with Cmin. These findings support the continued use of Cmin and call for stringent objective disease activity (bio-)markers (eg, endoscopy) to form the basis of personalized IFX therapy for Crohn's disease patients with IFX treatment failure.}, language = {en} } @article{BogdanovaMiklashevskyBogdanovaetal.2019, author = {Bogdanova, Oksana Yu and Miklashevsky, Alex A. and Bogdanova, Elena L. and Soldatenkova, O. B.}, title = {Academic Achievement in Math and Foreign Language: Individual Characteristics and Gender Stereotypes}, series = {Sibirskiy psikholoicheskiy zurnal - Siberian of Journal psychology}, journal = {Sibirskiy psikholoicheskiy zurnal - Siberian of Journal psychology}, number = {73}, publisher = {Tomsk state univ}, address = {Tomsk}, issn = {1726-7080}, doi = {10.17223/17267080/73/11}, pages = {176 -- 196}, year = {2019}, abstract = {The study aims to investigate the contribution of individual characteristics and gender stereotypes of secondary school pupils in academic achievement in math and foreign language. A sample of pupils reported in 6th and 7th grades (three waves) their self-perceived ability and motivation for math and foreign language learning, math and foreign language gender stereotypes, implicit theories of intelligence; academic achievement (grades) in math in foreign language is also included in the analysis. Regression analysis and Mann Whitney U Test demonstrated that self-perceived ability in math and incremental theory of intelligence are significant predictors for academic achievement in maths. Boys are characterised by higher level of self-perceived abilities and motivation for learning math. However, academic achievement of girls in maths and foreign languages are higher as compared to boys. Pupils learning two foreign languages demonstrate higher level of self-perceived abilities for motivation and learning math and less expressed gender stereotypes about success in learning math and foreign languages. Study findings can be used for designing educational programmes for mathematics and foreign languages, professional development and finding solutions for individualized approach in school education.}, language = {ru} } @inproceedings{GrumRappGronauetal.2019, author = {Grum, Marcus and Rapp, Simon and Gronau, Norbert and Albers, Albert}, title = {Accelerating knowledge}, series = {Business modeling and software design}, volume = {356}, booktitle = {Business modeling and software design}, editor = {Shishkov, Boris}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-24853-6}, doi = {10.1007/978-3-030-24854-3_7}, pages = {95 -- 113}, year = {2019}, abstract = {As knowledge-intensive processes are often carried out in teams and demand for knowledge transfers among various knowledge carriers, any optimization in regard to the acceleration of knowledge transfers obtains a great economic potential. Exemplified with product development projects, knowledge transfers focus on knowledge acquired in former situations and product generations. An adjustment in the manifestation of knowledge transfers in its concrete situation, here called intervention, therefore can directly be connected to the adequate speed optimization of knowledge-intensive process steps. This contribution presents the specification of seven concrete interventions following an intervention template. Further, it describes the design and results of a workshop with experts as a descriptive study. The workshop was used to assess the practical relevance of interventions designed as well as the identification of practical success factors and barriers of their implementation.}, language = {en} } @phdthesis{Eckert2019, author = {Eckert, Sebastian}, title = {Accessing active sites of molecular proton dynamics}, doi = {10.25932/publishup-42587}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-425870}, school = {Universit{\"a}t Potsdam}, pages = {xviii, 193}, year = {2019}, abstract = {The unceasing impact of intense sunlight on earth constitutes a continuous source of energy fueling countless natural processes. On a molecular level, the energy contained in the electromagnetic radiation is transferred through photochemical processes into chemical or thermal energy. In the course of such processes, photo-excitations promote molecules into thermally inaccessible excited states. This induces adaptations of their molecular geometry according to the properties of the excited state. Decay processes towards energetically lower lying states in transient molecular geometries result in the formation of excited state relaxation pathways. The photo-chemical relaxation mechanisms depend on the studied system itself, the interactions with its chemical environment and the character of the involved states. This thesis focuses on systems in which photo-induced deprotonation processes occur at specific atomic sites. To detect these excited-state proton dynamics at the affected atoms, a local probe of molecular electronic structure is required. Therefore, site-selective and orbital-specific K-edge soft X-ray spectroscopy techniques are used here to detect photo-induced proton dynamics in gaseous and liquid sample environments. The protonation of nitrogen (N) sites in organic molecules and the oxygen (O) atom in the water molecule are probed locally through transitions between 1s orbitals and the p-derived molecular valence electronic structure. The used techniques are X-ray absorption spectroscopy (XAS) and resonant inelastic X-ray scattering (RIXS). Both yield access to the unoccupied local valence electronic structure, whereas the latter additionally probes occupied states. We apply these probes in optical pump X-ray probe experiments to investigate valence excited-state proton transfer capabilities of aqueous 2-thiopyridone. A characteristic shift of N K-edge X-ray absorption resonances as well as a distinct X-ray emission line are established by us as spectral fingerprints of N deprotonation in the system. We utilize them to identify photo-induced N deprotonation of 2-thiopyridone on femtosecond timescales, in optical pump N K-edge RIXS probe measurements. We further establish excited state proton transfer mechanisms on picosecond and nanosecond timescales along the dominant relaxation pathways of 2-thiopyridone using transient N K-edge XAS. Despite being an excellent probe mechanism for valence excited-state proton dynamics, the K-edge core-excitation itself also disturbs the electronic structure at specific sites of a molecule. The rapid reaction of protons to 1s photo-excitations can yield directional structural distortions within the femtosecond core-excited state lifetime. These directional proton dynamics can change the energetic separation of eigenstates of the system and alter probabilities for radiative decay between them. Both effects yield spectral signatures of the dynamics in RIXS spectra. Using these signatures of RIXS transitions into electronically excited states, we investigate proton dynamics induced by N K-edge excitation in the amino-acid histidine. The minor core-excited state dynamics of histidine in basic and neutral chemical environments allow us to establish XAS and RIXS spectral signatures of different N protonation states at its imidazole N sites. Based on these signatures, we identify an excitation-site-independent N-H dissociation for N K-edge excitation under acidic conditions. Such directional structural deformations, induced by core-excitations, also make proton dynamics in electronic ground states accessible through RIXS transitions into vibrationally excited states. In that context, we interpret high resolution RIXS spectra of the water molecule for three O K-edge resonances based on quantum-chemical wave packet propagation simulations. We show that highly oriented ground state vibrational modes of coupled nuclear motion can be populated through RIXS processes by preparation of core-excited state nuclear wave packets with the same directionality. Based on that, we analytically derive the possibility to extract one-dimensional directional cuts through potential energy surfaces of molecular systems from the corresponding RIXS spectra. We further verify this concept through the extraction of the gas-phase water ground state potential along three coordinates from experimental data in comparison to quantum-chemical simulations of the potential energy surface. This thesis also contains contributions to instrumentation development for investigations of photo-induced molecular dynamics at high brilliance X-ray light sources. We characterize the setup used for the transient valence-excited state XAS measurements of 2-thiopyridone. Therein, a sub-micrometer thin liquid sample environment is established employing in-vacuum flat-jet technology, which enables a transmission experimental geometry. In combination with a MHz-laser system, we achieve a high detection sensitivity for photo-induced X-ray absorption changes. Additionally, we present conceptual improvements for temporal X-ray optical cross-correlation techniques based on transient changes of multilayer optical properties, which are crucial for the realization of femtosecond time-resolved studies at synchrotrons and free-electron lasers.}, language = {en} } @article{GefenTrevesKedemWeissetal.2019, author = {Gefen-Treves, Shany and Kedem, Isaac and Weiss, Gad and Wagner, Dirk and Tchernov, Dan and Kaplan, Aaron}, title = {Acclimation of a rocky shore algal reef builder Neogoniolithon sp. to changing illuminations}, series = {Limnology and oceanography e-lectures / Association for the Sciences of Limnology and Oceanography}, volume = {65}, journal = {Limnology and oceanography e-lectures / Association for the Sciences of Limnology and Oceanography}, number = {1}, publisher = {Wiley}, address = {Hoboken}, issn = {0024-3590}, doi = {10.1002/lno.11245}, pages = {27 -- 36}, year = {2019}, abstract = {Vermetid reefs and rocky shores are hot spots of biodiversity, often referred to as the subtropical equivalent of coral reefs. The development of the ecosystem depends on the activity of several reef builders, including red crustose coralline algae (CCA) such as Neogoniolithon brassica-florida. Despite its importance, little is known about Neogoniolithon sp. acclimation to rapid changes in light intensity and corresponding photosynthetic activity. To overcome the large spatial variability in the light field (due to location and the porous nature of the rocks) we grew Neogoniolithon sp. on glass slides and characterized its photosynthetic performance in response to various light intensities by following O-2 exchange and fluorescence parameters. This was also performed on rock-inhabiting thalli collected from the east Mediterranean basin. Generally, maximal photosynthetic rate was reached when Neogoniolithon sp. thalli grown under low illumination (such as in protected niches where the light intensity can be as low as 1\% of surface illumination) were examined. When exposed to light intensities higher than those experienced during growth, Neogoniolithon sp. activates adaptive/protective mechanisms such as state transition and nonphotochemical fluorescence quenching and increases the dark respiration thereafter. We find that the Fv/Fm parameter (variable/maximal fluorescence) is not suitable to assess photosynthetic performance in Neogoniolithon sp. and propose using instead an alternative parameter recently developed. Our findings help to clarify why Neogoniolithon sp. is usually observed in shaded niches along the reef surfaces.}, language = {en} } @article{YousfiBatoulisWeske2019, author = {Yousfi, Alaaeddine and Batoulis, Kimon and Weske, Mathias}, title = {Achieving Business Process Improvement via Ubiquitous Decision-Aware Business Processes}, series = {ACM Transactions on Internet Technology}, volume = {19}, journal = {ACM Transactions on Internet Technology}, number = {1}, publisher = {Association for Computing Machinery}, address = {New York}, issn = {1533-5399}, doi = {10.1145/3298986}, pages = {19}, year = {2019}, abstract = {Business process improvement is an endless challenge for many organizations. As long as there is a process, it must he improved. Nowadays, improvement initiatives are driven by professionals. This is no longer practical because people cannot perceive the enormous data of current business environments. Here, we introduce ubiquitous decision-aware business processes. They pervade the physical space, analyze the ever-changing environments, and make decisions accordingly. We explain how they can be built and used for improvement. Our approach can be a valuable improvement option to alleviate the workload of participants by helping focus on the crucial rather than the menial tasks.}, language = {en} } @article{CasselRischMayeretal.2019, author = {Cassel, Michael and Risch, Lucie and Mayer, Frank and Kaplick, Hannes and Engel, Aaron and Kulig, Kornelia and Bashford, Greg}, title = {Achilles tendon morphology assessed using image based spatial frequency analysis is altered among healthy elite adolescent athletes compared to recreationally active controls}, series = {Journal of science and medicine in sport : official journal of Sports Medicine Australia}, volume = {22}, journal = {Journal of science and medicine in sport : official journal of Sports Medicine Australia}, number = {8}, publisher = {Elsevier}, address = {Oxford}, issn = {1440-2440}, doi = {10.1016/j.jsams.2019.03.011}, pages = {882 -- 886}, year = {2019}, abstract = {Objectives: Although expected, tendon adaptations in adolescent elite athletes have been underreported. Morphologically, adaptations may occur by an increase in collagen fiber density and/or organization. These characteristics can be captured using spatial frequency parameters extracted from ultrasound images. This study aims to compare Achilles tendon (AT) morphology among sports-specific cohorts of elite adolescent athletes and to compare these findings to recreationally active controls by use of spatial frequency analysis. Design: Cross-sectional observational study. Method: In total, 334 healthy adolescent athletes from four sport categories (ball, combat, endurance, explosive strength) and 35 healthy controls were included. Longitudinal ultrasound scans were performed at the AT insertion and midportion. Intra-tendinous-morphology was quantified by performing spatial frequency analysis assessing eight parameters at standardized ROls. Increased values in five parameters suggest a higher structural organization, and in two parameters higher fiber density. One parameter represents a quotient combining both organization and fiber density. Results: Among athletes, only ball sport athletes exhibited an increase in one summative parameter at pre-insertion site compared to athletes from other sport categories. When compared to athletes, controls had significantly higher values of four parameters at pre-insertion and three parameters at midportion site reflecting differences in both, fiber organization and density. Conclusions: Intra-tendinous-morphology was similar in all groups of adolescent athletes. Higher values found in non-athletes might suggest higher AT fiber density and organization. It is yet unclear whether the lesser structural organization in young athletes represents initial AT pathology, or a physiological adaptive response at the fiber cross-linking level. (C) 2019 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.}, language = {en} } @article{ZeitlerYeAndreyevaetal.2019, author = {Zeitler, Stefanie and Ye, Lian and Andreyeva, Aksana and Schumacher, Fabian and Monti, Juliana and N{\"u}rnberg, Bernd and Nowak, Gabriel and Kleuser, Burkhard and Reichel, Martin and Fejtova, Anna and Kornhuber, Johannes and Rhein, Cosima and Friedland, Kristina}, title = {Acid sphingomyelinase - a regulator of canonical transient receptor potential channel 6 (TRPC6) activity}, series = {Journal of neurochemistry}, volume = {150}, journal = {Journal of neurochemistry}, number = {6}, publisher = {Wiley}, address = {Hoboken}, issn = {0022-3042}, doi = {10.1111/jnc.14823}, pages = {678 -- 690}, year = {2019}, abstract = {Recent investigations propose the acid sphingomyelinase (ASM)/ceramide system as a novel target for antidepressant action. ASM catalyzes the breakdown of the abundant membrane lipid sphingomyelin to the lipid messenger ceramide. This ASM-induced lipid modification induces a local shift in membrane properties, which influences receptor clustering and downstream signaling. Canonical transient receptor potential channels 6 (TRPC6) are non-selective cation channels located in the cell membrane that play an important role in dendritic growth, synaptic plasticity and cognition in the brain. They can be activated by hyperforin, an ingredient of the herbal remedy St. John's wort for treatment of depression disorders. Because of their role in the context of major depression, we investigated the crosstalk between the ASM/ceramide system and TRPC6 ion channels in a pheochromocytoma cell line 12 neuronal cell model (PC12 rat pheochromocytoma cell line). Ca2+ imaging experiments indicated that hyperforin-induced Ca2+ influx through TRPC6 channels is modulated by ASM activity. While antidepressants, known as functional inhibitors of ASM activity, reduced TRPC6-mediated Ca2+ influx, extracellular application of bacterial sphingomyelinase rebalanced TRPC6 activity in a concentration-related way. This effect was confirmed in whole-cell patch clamp electrophysiology recordings. Lipidomic analyses revealed a decrease in very long chain ceramide/sphingomyelin molar ratio after ASM inhibition, which was connected with changes in the abundance of TRPC6 channels in flotillin-1-positive lipid rafts as visualized by western blotting. Our data provide evidence that the ASM/ceramide system regulates TRPC6 channels likely by controlling their recruitment to specific lipid subdomains and thereby fine-tuning their physical properties.}, language = {en} } @article{BeckmannBeckerKadowetal.2019, author = {Beckmann, Nadine and Becker, Katrin Anne and Kadow, Stephanie and Schumacher, Fabian and Kramer, Melanie and Kuehn, Claudine and Schulz-Schaeffer, Walter J. and Edwards, Michael J. and Kleuser, Burkhard and Gulbins, Erich and Carpinteiro, Alexander}, title = {Acid Sphingomyelinase Deficiency Ameliorates Farber Disease}, series = {International journal of molecular sciences}, volume = {20}, journal = {International journal of molecular sciences}, number = {24}, publisher = {MDPI}, address = {Basel}, issn = {1422-0067}, doi = {10.3390/ijms20246253}, pages = {18}, year = {2019}, abstract = {Farber disease is a rare lysosomal storage disorder resulting from acid ceramidase deficiency and subsequent ceramide accumulation. No treatments for Farber disease are clinically available, and affected patients have a severely shortened lifespan. We have recently reported a novel acid ceramidase deficiency model that mirrors the human disease closely. Acid sphingomyelinase is the enzyme that generates ceramide upstream of acid ceramidase in the lysosomes. Using our acid ceramidase deficiency model, we tested if acid sphingomyelinase could be a potential novel therapeutic target for the treatment of Farber disease. A number of functional acid sphingomyelinase inhibitors are clinically available and have been used for decades to treat major depression. Using these as a therapeutic for Farber disease, thus, has the potential to improve central nervous symptoms of the disease as well, something all other treatment options for Farber disease can't achieve so far. As a proof-of-concept study, we first cross-bred acid ceramidase deficient mice with acid sphingomyelinase deficient mice in order to prevent ceramide accumulation. Double-deficient mice had reduced ceramide accumulation, fewer disease manifestations, and prolonged survival. We next targeted acid sphingomyelinase pharmacologically, to test if these findings would translate to a setting with clinical applicability. Surprisingly, the treatment of acid ceramidase deficient mice with the acid sphingomyelinase inhibitor amitriptyline was toxic to acid ceramidase deficient mice and killed them within a few days of treatment. In conclusion, our study provides the first proof-of-concept that acid sphingomyelinase could be a potential new therapeutic target for Farber disease to reduce disease manifestations and prolong survival. However, we also identified previously unknown toxicity of the functional acid sphingomyelinase inhibitor amitriptyline in the context of Farber disease, strongly cautioning against the use of this substance class for Farber disease patients.}, language = {en} } @article{AndresDelgadoErnstGalardiCastillaetal.2019, author = {Andr{\´e}s-Delgado, Laura and Ernst, Alexander and Galardi-Castilla, Mar{\´i}a and Bazaga, David and Peralta, Marina and M{\"u}nch, Juliane and Gonzalez-Rosa, Juan M. and Marques, In{\^e}s and Tessadori, Federico and de la Pompa, Jos{\´e} Luis and Vermot, Julien and Mercader, Nadia}, title = {Actin dynamics and the Bmp pathway drive apical extrusion of proepicardial cells}, series = {Development : Company of Biologists}, volume = {146}, journal = {Development : Company of Biologists}, number = {13}, publisher = {The Company of Biologists Ltd}, address = {Cambridge}, issn = {0950-1991}, doi = {10.1242/dev.174961}, pages = {15}, year = {2019}, abstract = {The epicardium, the outer mesothelial layer enclosing the myocardium, plays key roles in heart development and regeneration. During embryogenesis, the epicardium arises from the proepicardium (PE), a cell cluster that appears in the dorsal pericardium (DP) close to the venous pole of the heart. Little is known about how the PE emerges from the pericardial mesothelium. Using a zebrafish model and a combination of genetic tools, pharmacological agents and quantitative in vivo imaging, we reveal that a coordinated collective movement of DP cells drives PE formation. We found that Bmp signaling and the actomyosin cytoskeleton promote constriction of the DP, which enables PE cells to extrude apically. We provide evidence that cell extrusion, which has been described in the elimination of unfit cells from epithelia and the emergence of hematopoietic stem cells, is also a mechanism for PE cells to exit an organized mesothelium and fulfil their developmental fate to form a new tissue layer, the epicardium.}, language = {en} } @phdthesis{Adam2019, author = {Adam, Maurits}, title = {Action-goal predictions in infancy}, school = {Universit{\"a}t Potsdam}, pages = {137}, year = {2019}, language = {en} } @article{ZinkeGebelGranacheretal.2019, author = {Zinke, Fridolin and Gebel, Arnd and Granacher, Urs and Prieske, Olaf}, title = {Acute Effects of Short-Term Local Tendon Vibration on Plantar Flexor Torque, Muscle Contractile Properties, Neuromuscular and Brain Activity in Young Athletes}, series = {Journal of sports science \& medicine}, volume = {18}, journal = {Journal of sports science \& medicine}, number = {2}, publisher = {Department of Sports Medicine, Medical Faculty of Uludag University}, address = {Bursa}, issn = {1303-2968}, pages = {327 -- 336}, year = {2019}, abstract = {The purpose of this study was to examine the acute effects of short-term Achilles tendon vibration on plantar flexor torque, twitch contractile properties as well as muscle and cortical activity in young athletes. Eleven female elite soccer players aged 15.6 +/- 0.5 years participated in this study. Three different conditions were applied in randomized order: Achilles tendon vibration (80 Hz) for 30 and 300 s, and a passive control condition (300 s). Tests at baseline and following conditions included the assessment of peak plantar flexor torque during maximum voluntary contraction, electrically evoked muscle twitches (e.g., potentiated twitch peak torque [PT]), and electromyographic (EMG) activity of the plantar flexors. Additionally, electroencephalographic (EEG) activity of the primary motor and somatosensory cortex were assessed during a submaximal dynamic concentric-eccentric plantar flexion exercise using an elastic rubber band. Large-sized main effects of condition were found for EEG absolute alpha-1 and beta-1 band power (p <= 0.011; 1.5 <= d <= 2.6). Post-hoc tests indicated that alpha-1 power was significantly lower at 30 and 300 s (p = 0.009; d = 0.8) and beta-1 power significantly lower at 300 s (p < 0.001; d = 0.2) compared to control condition. No significant effect of condition was found for peak plantar flexor torque, electrical evoked muscle twitches, and EMG activity. In conclusion, short-term local Achilles tendon vibration induced lower brain activity (i.e., alpha-1 and beta-1 band power) but did not affect lower limb peak torque, twitch contractile properties, and muscle activity. Lower brain activity following short-term local Achilles tendon vibration may indicate improved cortical function during a submaximal dynamic exercise in female young soccer players.}, language = {en} } @article{ChaabeneBehmNegraetal.2019, author = {Chaabene, Helmi and Behm, David George and Negra, Yassine and Granacher, Urs}, title = {Acute Effects of Static Stretching on Muscle Strength and Power}, series = {Frontiers in Physiology}, volume = {10}, journal = {Frontiers in Physiology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-042X}, doi = {10.3389/fphys.2019.01468}, pages = {8}, year = {2019}, abstract = {The effects of static stretching (StS) on subsequent strength and power activities has been one of the most debated topics in sport science literature over the past decades. The aim of this review is (1) to summarize previous and current findings on the acute effects of StS on muscle strength and power performances; (2) to update readers' knowledge related to previous caveats; and (3) to discuss the underlying physiological mechanisms of short-duration StS when performed as single-mode treatment or when integrated into a full warm-up routine. Over the last two decades, StS has been considered harmful to subsequent strength and power performances. Accordingly, it has been recommended not to apply StS before strength- and power-related activities. More recent evidence suggests that when performed as a single-mode treatment or when integrated within a full warm-up routine including aerobic activity, dynamic-stretching, and sport-specific activities, short-duration StS (≤60 s per muscle group) trivially impairs subsequent strength and power activities (∆1-2\%). Yet, longer StS durations (>60 s per muscle group) appear to induce substantial and practically relevant declines in strength and power performances (∆4.0-7.5\%). Moreover, recent evidence suggests that when included in a full warm-up routine, short-duration StS may even contribute to lower the risk of sustaining musculotendinous injuries especially with high-intensity activities (e.g., sprint running and change of direction speed). It seems that during short-duration StS, neuromuscular activation and musculotendinous stiffness appear not to be affected compared with long-duration StS. Among other factors, this could be due to an elevated muscle temperature induced by a dynamic warm-up program. More specifically, elevated muscle temperature leads to increased muscle fiber conduction-velocity and improved binding of contractile proteins (actin, myosin). Therefore, our previous understanding of harmful StS effects on subsequent strength and power activities has to be updated. In fact, short-duration StS should be included as an important warm-up component before the uptake of recreational sports activities due to its potential positive effect on flexibility and musculotendinous injury prevention. However, in high-performance athletes, short-duration StS has to be applied with caution due to its negligible but still prevalent negative effects on subsequent strength and power performances, which could have an impact on performance during competition.}, language = {en} } @phdthesis{Paraskevopoulou2019, author = {Paraskevopoulou, Sofia}, title = {Adaptive genetic variation and responses to thermal stress in brachionid rotifers}, pages = {IV, 177}, year = {2019}, abstract = {The importance of cryptic diversity in rotifers is well understood regarding its ecological consequences, but there remains an in depth comprehension of the underlying molecular mechanisms and forces driving speciation. Temperature has been found several times to affect species spatio-temporal distribution and organisms' performance, but we lack information on the mechanisms that provide thermal tolerance to rotifers. High cryptic diversity was found recently in the freshwater rotifer "Brachionus calyciflorus", showing that the complex comprises at least four species: B. calyciflorus sensu stricto (s.s.), B. fernandoi, B. dorcas, and B. elevatus. The temporal succession among species which have been observed in sympatry led to the idea that temperature might play a crucial role in species differentiation. The central aim of this study was to unravel differences in thermal tolerance between species of the former B. calyciflorus species complex by comparing phenotypic and gene expression responses. More specifically, I used the critical maximum temperature as a proxy for inter-species differences in heat-tolerance; this was modeled as a bi-dimensional phenotypic trait taking into consideration the intention and the duration of heat stress. Significant differences on heat-tolerance between species were detected, with B. calyciflorus s.s. being able to tolerate higher temperatures than B. fernandoi. Based on evidence of within species neutral genetic variation, I further examined adaptive genetic variability within two different mtDNA lineages of the heat tolerant B. calyciflorus s.s. to identify SNPs and genes under selection that might reflect their adaptive history. These analyses did not reveal adaptive genetic variation related to heat, however, they show putatively adaptive genetic variation which may reflect local adaptation. Functional enrichment of putatively positively selected genes revealed signals of adaptation in genes related to "lipid metabolism", "xenobiotics biodegradation and metabolism" and "sensory system", comprising candidate genes which can be utilized in studies on local adaptation. An absence of genetically-based differences in thermal adaptation between the two mtDNA lineages, together with our knowledge that B. calyciflorus s.s. can withstand a broad range of temperatures, led to the idea to further investigate shared transcriptomic responses to long-term exposure to high and low temperatures regimes. With this, I identified candidate genes that are involved in the response to temperature imposed stress. Lastly, I used comparative transcriptomics to examine responses to imposed heat-stress in heat-tolerant and heat-sensitive Brachionus species. I found considerably different patterns of gene expression in the two species. Most striking are patterns of expression regarding the heat shock proteins (hsps) between the two species. In the heat-tolerant, B. calyciflorus s.s., significant up-regulation of hsps at low temperatures was indicative of a stress response at the cooler end of the temperature regimes tested here. In contrast, in the heat-sensitive B. fernandoi, hsps generally exhibited up-regulation of these genes along with rising temperatures. Overall, identification of differences in expression of genes suggests suppression of protein biosynthesis to be a mechanism to increase thermal tolerance. Observed patterns in population growth are correlated with the hsp gene expression differences, indicating that this physiological stress response is indeed related to phenotypic life history performance.}, language = {en} } @article{RadchukReedTeplitskyetal.2019, author = {Radchuk, Viktoriia and Reed, Thomas and Teplitsky, Celine and van de Pol, Martijn and Charmantier, Anne and Hassall, Christopher and Adamik, Peter and Adriaensen, Frank and Ahola, Markus P. and Arcese, Peter and Miguel Aviles, Jesus and Balbontin, Javier and Berg, Karl S. and Borras, Antoni and Burthe, Sarah and Clobert, Jean and Dehnhard, Nina and de Lope, Florentino and Dhondt, Andre A. and Dingemanse, Niels J. and Doi, Hideyuki and Eeva, Tapio and Fickel, J{\"o}rns and Filella, Iolanda and Fossoy, Frode and Goodenough, Anne E. and Hall, Stephen J. G. and Hansson, Bengt and Harris, Michael and Hasselquist, Dennis and Hickler, Thomas and Jasmin Radha, Jasmin and Kharouba, Heather and Gabriel Martinez, Juan and Mihoub, Jean-Baptiste and Mills, James A. and Molina-Morales, Mercedes and Moksnes, Arne and Ozgul, Arpat and Parejo, Deseada and Pilard, Philippe and Poisbleau, Maud and Rousset, Francois and R{\"o}del, Mark-Oliver and Scott, David and Carlos Senar, Juan and Stefanescu, Constanti and Stokke, Bard G. and Kusano, Tamotsu and Tarka, Maja and Tarwater, Corey E. and Thonicke, Kirsten and Thorley, Jack and Wilting, Andreas and Tryjanowski, Piotr and Merila, Juha and Sheldon, Ben C. and Moller, Anders Pape and Matthysen, Erik and Janzen, Fredric and Dobson, F. Stephen and Visser, Marcel E. and Beissinger, Steven R. and Courtiol, Alexandre and Kramer-Schadt, Stephanie}, title = {Adaptive responses of animals to climate change are most likely insufficient}, series = {Nature Communications}, volume = {10}, journal = {Nature Communications}, publisher = {Nature Publ. Group}, address = {London}, issn = {2041-1723}, doi = {10.1038/s41467-019-10924-4}, pages = {14}, year = {2019}, abstract = {Biological responses to climate change have been widely documented across taxa and regions, but it remains unclear whether species are maintaining a good match between phenotype and environment, i.e. whether observed trait changes are adaptive. Here we reviewed 10,090 abstracts and extracted data from 71 studies reported in 58 relevant publications, to assess quantitatively whether phenotypic trait changes associated with climate change are adaptive in animals. A meta-analysis focussing on birds, the taxon best represented in our dataset, suggests that global warming has not systematically affected morphological traits, but has advanced phenological traits. We demonstrate that these advances are adaptive for some species, but imperfect as evidenced by the observed consistent selection for earlier timing. Application of a theoretical model indicates that the evolutionary load imposed by incomplete adaptive responses to ongoing climate change may already be threatening the persistence of species.}, language = {en} } @article{BenderThiemeGronauetal.2019, author = {Bender, Benedict and Thieme, Johanna Luise and Gronau, Norbert and Wenig, Christoph and Menold, Paul}, title = {Adaptive Spielifizierung im KVP}, series = {ERP Management}, volume = {15}, journal = {ERP Management}, number = {3}, publisher = {Gito}, address = {Berlin}, issn = {1860-6725}, pages = {57 -- 59}, year = {2019}, abstract = {F{\"u}r die Wettbewerbsf{\"a}higkeit von Unternehmen hat der Kontinuierliche Verbesserungsprozess (KVP) eine hohe Bedeutung. Hinsichtlich der Qualit{\"a}t und Quantit{\"a}t der Beitr{\"a}ge f{\"u}r den KVP durch die Mitarbeitenden stoßen Unternehmen, insbesondere KMU, jedoch auf vielf{\"a}ltige Herausforderungen. Diesen Problemen k{\"o}nnen Unternehmen durch das KVP-Tool begegnen, welches im Projekt „Adaptive Spielifizierung im KVP" entwickelt wird. Durch die Digitalisierung und Spielifizierung des Prozes- ses im KVP-Tool wird die kontinuierliche Beteiligung nachhaltig durch intrinsische Anreize gef{\"o}rdert. Die Neuartigkeit des Projektes ergibt sich aus der Adaptivit{\"a}t der Spielifizierung, also die Wechselwirkung zu den Nutzenden. Dabei werden zwei Aspekte fokussiert: unterschiedliche Spielertypen und Marktdynamik.}, language = {de} } @article{NeiberKahlWiggeringetal.2019, author = {Neiber, Marco Thomas and Kahl, Sandra M. and Wiggering, Benedikt and Glaubrecht, Matthias}, title = {Adding the West-African riverine component}, series = {Zootaxa : an international journal of zootaxonomy ; a rapid international journal for animal taxonomists}, volume = {4674}, journal = {Zootaxa : an international journal of zootaxonomy ; a rapid international journal for animal taxonomists}, number = {3}, publisher = {Magnolia Press}, address = {Auckland}, issn = {1175-5326}, doi = {10.11646/zootaxa.4674.3.1}, pages = {301 -- 328}, year = {2019}, abstract = {While Africa's lacustrine gastropod fauna, in particular of Lake Tanganyika, has received much attention, the continent's riverine malacofauna has long been neglected. Pseudocleopatra is a relatively poorly known paludomid gastropod genus with species found throughout the lower reaches of the West African Volta and Congo rivers. In the course of ongoing systematic revisions of African paludomids, we present here a morphometric analysis and revision of the recent species assigned to the genus, i.e., P. togoensis, P. voltana, P. dartevellei and P. bennikei, to improve taxonomic acuity for this group. We use available museum material for geometric morphometrics, multivariate ratio analysis and comparisons of radular and opercular characters. Our results demonstrate that the four recent species of Pseudocleopatra are clearly distinguishable on the basis of ratios of shell measurements as well as radular and opercular characters. Pseudocleopatra has generic-level synapomorphies including: concentric opercula with relatively large paucispiral nuclei, and rachidian radular teeth with usually 13-20 cusps. On the basis of this characterisation, the nominal species Cleopatra broecki is transferred to Pseudocleopatra. Additionally, the nominal taxon P. bennikei is synonymized with P. broecki n. comb. The phylogenetic relationships of Pseudocleopatra are currently unknown, but the observed tendency of some fossil taxa assigned to Pseudocleopatra towards thalassoidism, i.e., the resemblance to marine gastropods, has led to the hypothesis that some of the thalassoid endemics in Lake Tanganyika may have originated from or be related to Pseudocleopatra. Should this hypothesis be correct, which is in need of testing by molecular genetic methods when suitable samples become available, Pseudocleopatra may play a crucial role in understanding of the evolution of thalassoidism in African Paludomidae.}, language = {en} } @misc{HesseMatthiesSinzigetal.2019, author = {Hesse, G{\"u}nter and Matthies, Christoph and Sinzig, Werner and Uflacker, Matthias}, title = {Adding Value by Combining Business and Sensor Data}, series = {Database Systems for Advanced Applications}, volume = {11448}, journal = {Database Systems for Advanced Applications}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-18590-9}, issn = {0302-9743}, doi = {10.1007/978-3-030-18590-9_80}, pages = {528 -- 532}, year = {2019}, abstract = {Industry 4.0 and the Internet of Things are recent developments that have lead to the creation of new kinds of manufacturing data. Linking this new kind of sensor data to traditional business information is crucial for enterprises to take advantage of the data's full potential. In this paper, we present a demo which allows experiencing this data integration, both vertically between technical and business contexts and horizontally along the value chain. The tool simulates a manufacturing company, continuously producing both business and sensor data, and supports issuing ad-hoc queries that answer specific questions related to the business. In order to adapt to different environments, users can configure sensor characteristics to their needs.}, language = {en} } @article{WrightWachs2019, author = {Wright, Michelle F. and Wachs, Sebastian}, title = {Adolescents' Psychological Consequences and Cyber Victimization}, series = {International Journal of Environmental Research and Public Health}, volume = {16}, journal = {International Journal of Environmental Research and Public Health}, publisher = {MDPI AG}, address = {Basel}, issn = {1661-7827}, doi = {10.3390/ijerph16142493}, pages = {11}, year = {2019}, abstract = {Cyber victimization research reveals various personal and contextual correlations and negative consequences associated with this experience. Despite increasing attention on cyber victimization, few studies have examined such experiences among ethnic minority adolescents. The purpose of the present study was to examine the moderating effect of ethnicity in the longitudinal associations among cyber victimization, school-belongingness, and psychological consequences (i.e., depression, loneliness, anxiety). These associations were investigated among 416 Latinx and white adolescents (46\% female; M age = 13.89, SD = 0.41) from one middle school in the United States. They answered questionnaires on cyber victimization, school belongingness, depression, loneliness, and anxiety in the 7th grade (Time 1). One year later, in the 8th grade (Time 2), they completed questionnaires on depression, loneliness, and anxiety. Low levels of school-belongingness strengthened the positive relationships between cyber victimization and Time 2 depression and anxiety, especially among Latinx adolescents. The positive association between cyber victimization and Time 2 loneliness was strengthened for low levels of school-belongingness for all adolescents. These findings may indicate that cyber victimization threatens adolescents' school-belongingness, which has implications for their emotional adjustment. Such findings underscore the importance of considering diverse populations when examining cyber victimization.}, language = {en} } @article{BonacheGonzalezMendezKrahe2019, author = {Bonache, Helena and Gonzalez-Mendez, Rosaura and Krahe, Barbara}, title = {Adult attachment styles, destructive conflict resolution, and the experience of intimate partner violence}, series = {Journal of interpersonal violence : concerned with the study and treatment of victims and perpetrators of physical and sexual violence}, volume = {34}, journal = {Journal of interpersonal violence : concerned with the study and treatment of victims and perpetrators of physical and sexual violence}, number = {2}, publisher = {Sage Publ.}, address = {Thousand Oaks}, issn = {0886-2605}, doi = {10.1177/0886260516640776}, pages = {287 -- 309}, year = {2019}, abstract = {Although there is ample evidence linking insecure attachment styles and intimate partner violence (IPV), little is known about the psychological processes underlying this association, especially from the victim's perspective. The present study examined how attachment styles relate to the experience of sexual and psychological abuse, directly or indirectly through destructive conflict resolution strategies, both self-reported and attributed to their opposite-sex romantic partner. In an online survey, 216 Spanish undergraduates completed measures of adult attachment style, engagement and withdrawal conflict resolution styles shown by self and partner, and victimization by an intimate partner in the form of sexual coercion and psychological abuse. As predicted, anxious and avoidant attachment styles were directly related to both forms of victimization. Also, an indirect path from anxious attachment to IPV victimization was detected via destructive conflict resolution strategies. Specifically, anxiously attached participants reported a higher use of conflict engagement by themselves and by their partners. In addition, engagement reported by the self and perceived in the partner was linked to an increased probability of experiencing sexual coercion and psychological abuse. Avoidant attachment was linked to higher withdrawal in conflict situations, but the paths from withdrawal to perceived partner engagement, sexual coercion, and psychological abuse were non-significant. No gender differences in the associations were found. The discussion highlights the role of anxious attachment in understanding escalating patterns of destructive conflict resolution strategies, which may increase the vulnerability to IPV victimization.}, language = {en} }