@unpublished{Alsaedy2016,
  author    = {Alsaedy, Ammar},
  title     = {Variational primitive of a differential form},
  volume    = {5},
  number    = {4},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {2193-6943},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-89223},
  pages     = {8},
  year      = {2016},
  abstract  = {In this paper we specify the Dirichlet to Neumann operator related to the Cauchy problem for the gradient operator with data on a part of the boundary. To this end, we consider a nonlinear relaxation of this problem which is a mixed boundary problem of Zaremba type for the p-Laplace equation.},
  language  = {en}
}
@unpublished{AlsaedyTarkhanov2016,
  author    = {Alsaedy, Ammar and Tarkhanov, Nikolai Nikolaevich},
  title     = {A Hilbert boundary value problem for generalised Cauchy-Riemann equations},
  volume    = {5},
  number    = {1},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {2193-6943},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-86109},
  pages     = {21},
  year      = {2016},
  abstract  = {We elaborate a boundary Fourier method for studying an analogue of the Hilbert problem for analytic functions within the framework of generalised Cauchy-Riemann equations. The boundary value problem need not satisfy the Shapiro-Lopatinskij condition and so it fails to be Fredholm in Sobolev spaces. We show a solvability condition of the Hilbert problem, which looks like those for ill-posed problems, and construct an explicit formula for approximate solutions.},
  language  = {en}
}
@phdthesis{Berner2016,
  author    = {Berner, Nadine},
  title     = {Deciphering multiple changes in complex climate time series using Bayesian inference},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-100065},
  school      = {Universit{\"a}t Potsdam},
  pages     = {xvi, 135},
  year      = {2016},
  abstract  = {Change points in time series are perceived as heterogeneities in the statistical or dynamical characteristics of the observations. Unraveling such transitions yields essential information for the understanding of the observed system's intrinsic evolution and potential external influences. A precise detection of multiple changes is therefore of great importance for various research disciplines, such as environmental sciences, bioinformatics and economics. The primary purpose of the detection approach introduced in this thesis is the investigation of transitions underlying direct or indirect climate observations. In order to develop a diagnostic approach capable to capture such a variety of natural processes, the generic statistical features in terms of central tendency and dispersion are employed in the light of Bayesian inversion. In contrast to established Bayesian approaches to multiple changes, the generic approach proposed in this thesis is not formulated in the framework of specialized partition models of high dimensionality requiring prior specification, but as a robust kernel-based approach of low dimensionality employing least informative prior distributions. First of all, a local Bayesian inversion approach is developed to robustly infer on the location and the generic patterns of a single transition. The analysis of synthetic time series comprising changes of different observational evidence, data loss and outliers validates the performance, consistency and sensitivity of the inference algorithm. To systematically investigate time series for multiple changes, the Bayesian inversion is extended to a kernel-based inference approach. By introducing basic kernel measures, the weighted kernel inference results are composed into a proxy probability to a posterior distribution of multiple transitions. The detection approach is applied to environmental time series from the Nile river in Aswan and the weather station Tuscaloosa, Alabama comprising documented changes. The method's performance confirms the approach as a powerful diagnostic tool to decipher multiple changes underlying direct climate observations. Finally, the kernel-based Bayesian inference approach is used to investigate a set of complex terrigenous dust records interpreted as climate indicators of the African region of the Plio-Pleistocene period. A detailed inference unravels multiple transitions underlying the indirect climate observations, that are interpreted as conjoint changes. The identified conjoint changes coincide with established global climate events. In particular, the two-step transition associated to the establishment of the modern Walker-Circulation contributes to the current discussion about the influence of paleoclimate changes on the environmental conditions in tropical and subtropical Africa at around two million years ago.},
  language  = {en}
}
@unpublished{BlanchardKraemer2016,
  author    = {Blanchard, Gilles and Kr{\"a}mer, Nicole},
  title     = {Convergence rates of kernel conjugate gradient for random design regression},
  volume    = {5},
  number    = {8},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {2193-6943},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-94195},
  pages     = {31},
  year      = {2016},
  abstract  = {We prove statistical rates of convergence for kernel-based least squares regression from i.i.d. data using a conjugate gradient algorithm, where regularization against overfitting is obtained by early stopping. This method is related to Kernel Partial Least Squares, a regression method that combines supervised dimensionality reduction with least squares projection. Following the setting introduced in earlier related literature, we study so-called "fast convergence rates" depending on the regularity of the target regression function (measured by a source condition in terms of the kernel integral operator) and on the effective dimensionality of the data mapped into the kernel space. We obtain upper bounds, essentially matching known minimax lower bounds, for the L^2 (prediction) norm as well as for the stronger Hilbert norm, if the true regression function belongs to the reproducing kernel Hilbert space. If the latter assumption is not fulfilled, we obtain similar convergence rates for appropriate norms, provided additional unlabeled data are available.},
  language  = {en}
}
@unpublished{BlanchardMuecke2016,
  author    = {Blanchard, Gilles and M{\"u}cke, Nicole},
  title     = {Optimal rates for regularization of statistical inverse learning problems},
  volume    = {5},
  number    = {5},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {2193-6943},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-89782},
  pages     = {36},
  year      = {2016},
  abstract  = {We consider a statistical inverse learning problem, where we observe the image of a function f through a linear operator A at i.i.d. random design points X_i, superposed with an additional noise. The distribution of the design points is unknown and can be very general. We analyze simultaneously the direct (estimation of Af) and the inverse (estimation of f) learning problems. In this general framework, we obtain strong and weak minimax optimal rates of convergence (as the number of observations n grows large) for a large class of spectral regularization methods over regularity classes defined through appropriate source conditions. This improves on or completes previous results obtained in related settings. The optimality of the obtained rates is shown not only in the exponent in n but also in the explicit dependence of the constant factor in the variance of the noise and the radius of the source condition set.},
  language  = {en}
}
@unpublished{DereudreMazzonettoRoelly2016,
  author    = {Dereudre, David and Mazzonetto, Sara and Roelly, Sylvie},
  title     = {Exact simulation of Brownian diffusions with drift admitting jumps},
  volume    = {5},
  number    = {7},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {2193-6943},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-91049},
  pages     = {25},
  year      = {2016},
  abstract  = {Using an algorithm based on a retrospective rejection sampling scheme, we propose an exact simulation of a Brownian diffusion whose drift admits several jumps. We treat explicitly and extensively the case of two jumps, providing numerical simulations. Our main contribution is to manage the technical difficulty due to the presence of two jumps thanks to a new explicit expression of the transition density of the skew Brownian motion with two semipermeable barriers and a constant drift.},
  language  = {en}
}
@unpublished{FedchenkoTarkhanov2016,
  author    = {Fedchenko, Dmitry and Tarkhanov, Nikolai Nikolaevich},
  title     = {Boundary value problems for elliptic complexes},
  volume    = {5},
  number    = {3},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {2193-6943},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-86705},
  pages     = {12},
  year      = {2016},
  abstract  = {The aim of this paper is to bring together two areas which are of great importance for the study of overdetermined boundary value problems. The first area is homological algebra which is the main tool in constructing the formal theory of overdetermined problems. And the second area is the global calculus of pseudodifferential operators which allows one to develop explicit analysis.},
  language  = {en}
}
@unpublished{GairingHoegeleKosenkova2016,
  author    = {Gairing, Jan and H{\"o}gele, Michael and Kosenkova, Tetiana},
  title     = {Transportation distances and noise sensitivity of multiplicative L{\´e}vy SDE with applications},
  volume    = {5},
  number    = {2},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {2193-6943},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-86693},
  pages     = {24},
  year      = {2016},
  abstract  = {This article assesses the distance between the laws of stochastic differential equations with multiplicative L{\´e}vy noise on path space in terms of their characteristics. The notion of transportation distance on the set of L{\´e}vy kernels introduced by Kosenkova and Kulik yields a natural and statistically tractable upper bound on the noise sensitivity. This extends recent results for the additive case in terms of coupling distances to the multiplicative case. The strength of this notion is shown in a statistical implementation for simulations and the example of a benchmark time series in paleoclimate.},
  language  = {en}
}
@phdthesis{Gopalakrishnan2016,
  author    = {Gopalakrishnan, Sathej},
  title     = {Mathematical modelling of host-disease-drug interactions in HIV disease},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-100100},
  school      = {Universit{\"a}t Potsdam},
  pages     = {121},
  year      = {2016},
  abstract  = {The human immunodeficiency virus (HIV) has resisted nearly three decades of efforts targeting a cure. Sustained suppression of the virus has remained a challenge, mainly due to the remarkable evolutionary adaptation that the virus exhibits by the accumulation of drug-resistant mutations in its genome. Current therapeutic strategies aim at achieving and maintaining a low viral burden and typically involve multiple drugs. The choice of optimal combinations of these drugs is crucial, particularly in the background of treatment failure having occurred previously with certain other drugs. An understanding of the dynamics of viral mutant genotypes aids in the assessment of treatment failure with a certain drug combination, and exploring potential salvage treatment regimens. Mathematical models of viral dynamics have proved invaluable in understanding the viral life cycle and the impact of antiretroviral drugs. However, such models typically use simplified and coarse-grained mutation schemes, that curbs the extent of their application to drug-specific clinical mutation data, in order to assess potential next-line therapies. Statistical models of mutation accumulation have served well in dissecting mechanisms of resistance evolution by reconstructing mutation pathways under different drug-environments. While these models perform well in predicting treatment outcomes by statistical learning, they do not incorporate drug effect mechanistically. Additionally, due to an inherent lack of temporal features in such models, they are less informative on aspects such as predicting mutational abundance at treatment failure. This limits their application in analyzing the pharmacology of antiretroviral drugs, in particular, time-dependent characteristics of HIV therapy such as pharmacokinetics and pharmacodynamics, and also in understanding the impact of drug efficacy on mutation dynamics. In this thesis, we develop an integrated model of in vivo viral dynamics incorporating drug-specific mutation schemes learned from clinical data. Our combined modelling approach enables us to study the dynamics of different mutant genotypes and assess mutational abundance at virological failure. As an application of our model, we estimate in vivo fitness characteristics of viral mutants under different drug environments. Our approach also extends naturally to multiple-drug therapies. Further, we demonstrate the versatility of our model by showing how it can be modified to incorporate recently elucidated mechanisms of drug action including molecules that target host factors. Additionally, we address another important aspect in the clinical management of HIV disease, namely drug pharmacokinetics. It is clear that time-dependent changes in in vivo drug concentration could have an impact on the antiviral effect, and also influence decisions on dosing intervals. We present a framework that provides an integrated understanding of key characteristics of multiple-dosing regimens including drug accumulation ratios and half-lifes, and then explore the impact of drug pharmacokinetics on viral suppression. Finally, parameter identifiability in such nonlinear models of viral dynamics is always a concern, and we investigate techniques that alleviate this issue in our setting.},
  language  = {en}
}
@phdthesis{Ludewig2016,
  author    = {Ludewig, Matthias},
  title     = {Path integrals on manifolds with boundary and their asymptotic expansions},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-94387},
  school      = {Universit{\"a}t Potsdam},
  pages     = {146},
  year      = {2016},
  abstract  = {It is "scientific folklore" coming from physical heuristics that solutions to the heat equation on a Riemannian manifold can be represented by a path integral. However, the problem with such path integrals is that they are notoriously ill-defined. One way to make them rigorous (which is often applied in physics) is finite-dimensional approximation, or time-slicing approximation: Given a fine partition of the time interval into small subintervals, one restricts the integration domain to paths that are geodesic on each subinterval of the partition. These finite-dimensional integrals are well-defined, and the (infinite-dimensional) path integral then is defined as the limit of these (suitably normalized) integrals, as the mesh of the partition tends to zero. In this thesis, we show that indeed, solutions to the heat equation on a general compact Riemannian manifold with boundary are given by such time-slicing path integrals. Here we consider the heat equation for general Laplace type operators, acting on sections of a vector bundle. We also obtain similar results for the heat kernel, although in this case, one has to restrict to metrics satisfying a certain smoothness condition at the boundary. One of the most important manipulations one would like to do with path integrals is taking their asymptotic expansions; in the case of the heat kernel, this is the short time asymptotic expansion. In order to use time-slicing approximation here, one needs the approximation to be uniform in the time parameter. We show that this is possible by giving strong error estimates. Finally, we apply these results to obtain short time asymptotic expansions of the heat kernel also in degenerate cases (i.e. at the cut locus). Furthermore, our results allow to relate the asymptotic expansion of the heat kernel to a formal asymptotic expansion of the infinite-dimensional path integral, which gives relations between geometric quantities on the manifold and on the loop space. In particular, we show that the lowest order term in the asymptotic expansion of the heat kernel is essentially given by the Fredholm determinant of the Hessian of the energy functional. We also investigate how this relates to the zeta-regularized determinant of the Jacobi operator along minimizing geodesics.},
  language  = {en}
}