@book{Katagi2012, author = {Katagi, Jun}, title = {Kommunale Gebietsreform und Dezentralisierung : Vergleich zwischen Japan und Deutschland ; Welches Land liegt weiter vorn?}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-166-0}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-57864}, publisher = {Universit{\"a}t Potsdam}, pages = {103}, year = {2012}, abstract = {In Japan wurden die sogenannten „Heisei no Daigappei" (Große kommunale Gebietsreform) im Zeitraum von 1999 bis 2006 durchgef{\"u}hrt. Im Ergebnis hat sich die Anzahl der Gemeinden von 3.232 auf 1.727 - also um die H{\"a}lfte - reduziert. Auch in den neuen Bundesl{\"a}ndern in Deutschland sind in den letzten Jahren wieder kommunale Gebietsreformen (Gemeindefusionen) durchgef{\"u}hrt worden. Trotzdem gibt es in Deutschland noch etwa 12.000 Gemeinden. Im Vergleich mit Japan ist die Gemeindegr{\"o}ße also deutlich geringer. Mit dem vorliegenden Beitrag sollen die Reformunterschiede zwischen Deutschland und Japan erkl{\"a}rt werden. Gefragt wird nach der „Richtung" und der „St{\"a}rke" der verschiedenen Vektoren (Einflussfaktoren) im Reformprozess der Gemeindefusionen. Besonders reformf{\"o}rdernd wirken in Japan die Vektoren Dezentralisierungsdruck und {\"o}ffentliche Finanzkrise. Die Unterschiede zwischen Japan und Deutschland beim Vektor demographischer Wandel konnten nicht betrachtet werden. In Deutschland sind f{\"u}r den Reformfortschritt vor allem die Vektoren b{\"u}rgernahe Demokratie, {\"o}rtliche Verbundenheit, die Existenz des Ehrenamtsprinzips sowie die Erg{\"a}nzungsfunktion der Kreise und {\"A}mter ausschlaggebend. Insgesamt betrachtet wirken die Vektoren in Japan st{\"a}rker reformf{\"o}rdernd als in Deutschland. Deshalb sind im Reformergebnis die Gebietsstrukturen der Gemeinden in Japan derzeit gr{\"o}ßer als in Deutschland.}, language = {de} } @misc{MorrisSaltRailaetal.2012, author = {Morris, Penelope J. and Salt, Carina and Raila, Jens and Brenten, Thomas and Kohn, Barbara and Schweigert, Florian J. and Zentek, J{\"u}rgen}, title = {Safety evaluation of vitamin A in growing dogs}, series = {Potsprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Potsprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {686}, doi = {10.25932/publishup-41492}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-414929}, pages = {10}, year = {2012}, abstract = {The safe upper limit for inclusion of vitamin A in complete diets for growing dogs is uncertain, with the result that current recommendations range from 5.24 to 104.80 mu mol retinol (5000 to 100 000 IU vitamin A)/4184 kJ (1000 kcal) metabolisable energy (ME). The aim of the present study was to determine the effect of feeding four concentrations of vitamin A to puppies from weaning until 1 year of age. A total of forty-nine puppies, of two breeds, Labrador Retriever and Miniature Schnauzer, were randomly assigned to one of four treatment groups. Following weaning at 8 weeks of age, puppies were fed a complete food supplemented with retinyl acetate diluted in vegetable oil and fed at 1ml oil/100 g diet to achieve an intake of 5.24, 13.10, 78.60 and 104.80 mu mol retinol (5000, 12 500, 75 000 and 100 000 IU vitamin A)/4184 kJ (1000 kcal) ME. Fasted blood and urine samples were collected at 8, 10, 12, 14, 16, 20, 26, 36 and 52 weeks of age and analysed for markers of vitamin A metabolism and markers of safety including haematological and biochemical variables, bone-specific alkaline phosphatase, cross-linked carboxyterminal telopeptides of type I collagen and dual-energy X-ray absorptiometry. Clinical examinations were conducted every 4 weeks. Data were analysed by means of a mixed model analysis with Bonferroni corrections for multiple endpoints. There was no effect of vitamin A concentration on any of the parameters, with the exception of total serum retinyl esters, and no effect of dose on the number, type and duration of adverse events. We therefore propose that 104.80 mu mol retinol (100 000 IU vitamin A)/4184 kJ (1000 kcal) is a suitable safe upper limit for use in the formulation of diets designed for puppy growth.}, language = {en} } @misc{CaliendoHogenacker2012, author = {Caliendo, Marco and Hogenacker, Jens}, title = {The German labor market after the Great Recession}, series = {Postprints der Universit{\"a}t Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe}, number = {129}, issn = {1867-5808}, doi = {10.25932/publishup-43519}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-435195}, pages = {26}, year = {2012}, abstract = {The reaction of the German labor market to the Great Recession 2008/09 was relatively mild - especially compared to other countries. The reason lies not only in the specific type of the recession - which was favorable for the German economy structure - but also in a series of labor market reforms initiated between 2002 and 2005 altering, inter alia, labor supply incentives. However, irrespective of the mild response to the Great Recession, there are a number of substantial future challenges the German labor market will soon have to face. Female labor supply still lies well below that of other countries and a massive demographic change over the next 50 years will have substantial effects on labor supply as well as the pension system. In addition, due to a skill-biased technological change over the next decades, firms will face problems of finding employees with adequate skills. The aim of this paper is threefold. First, we outline why the German labor market reacted in such a mild fashion, describe current economic trends of the labor market in light of general trends in the European Union, and reveal some of the main associated challenges. Thereafter, the paper analyzes recent reforms of the main institutional settings of the labor market which influence labor supply. Finally, based on the status quo of these institutional settings, the paper gives a brief overview of strategies to combat adequately the challenges in terms of labor supply and to ensure economic growth in the future.}, language = {en} } @misc{KleessenNikoloski2012, author = {Kleessen, Sabrina and Nikoloski, Zoran}, title = {Dynamic regulatory on/off minimization for biological systems under internal temporal perturbations}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe}, number = {852}, issn = {1866-8372}, doi = {10.25932/publishup-43112}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-431128}, pages = {15}, year = {2012}, abstract = {Background: Flux balance analysis (FBA) together with its extension, dynamic FBA, have proven instrumental for analyzing the robustness and dynamics of metabolic networks by employing only the stoichiometry of the included reactions coupled with adequately chosen objective function. In addition, under the assumption of minimization of metabolic adjustment, dynamic FBA has recently been employed to analyze the transition between metabolic states. Results: Here, we propose a suite of novel methods for analyzing the dynamics of (internally perturbed) metabolic networks and for quantifying their robustness with limited knowledge of kinetic parameters. Following the biochemically meaningful premise that metabolite concentrations exhibit smooth temporal changes, the proposed methods rely on minimizing the significant fluctuations of metabolic profiles to predict the time-resolved metabolic state, characterized by both fluxes and concentrations. By conducting a comparative analysis with a kinetic model of the Calvin-Benson cycle and a model of plant carbohydrate metabolism, we demonstrate that the principle of regulatory on/off minimization coupled with dynamic FBA can accurately predict the changes in metabolic states. Conclusions: Our methods outperform the existing dynamic FBA-based modeling alternatives, and could help in revealing the mechanisms for maintaining robustness of dynamic processes in metabolic networks over time.}, language = {en} } @misc{KrippendorffOyarzunHuisinga2012, author = {Krippendorff, Ben-Fillippo and Oyarz{\´u}n, Diego A. and Huisinga, Wilhelm}, title = {Predicting the F(ab)-mediated effect of monoclonal antibodies in vivo by combining cell-level kinetic and pharmacokinetic modelling}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {958}, issn = {1866-8372}, doi = {10.25932/publishup-43105}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-431051}, pages = {125 -- 139}, year = {2012}, abstract = {Cell-level kinetic models for therapeutically relevant processes increasingly benefit the early stages of drug development. Later stages of the drug development processes, however, rely on pharmacokinetic compartment models while cell-level dynamics are typically neglected. We here present a systematic approach to integrate cell-level kinetic models and pharmacokinetic compartment models. Incorporating target dynamics into pharmacokinetic models is especially useful for the development of therapeutic antibodies because their effect and pharmacokinetics are inherently interdependent. The approach is illustrated by analysing the F(ab)-mediated inhibitory effect of therapeutic antibodies targeting the epidermal growth factor receptor. We build a multi-level model for anti-EGFR antibodies by combining a systems biology model with in vitro determined parameters and a pharmacokinetic model based on in vivo pharmacokinetic data. Using this model, we investigated in silico the impact of biochemical properties of anti-EGFR antibodies on their F(ab)-mediated inhibitory effect. The multi-level model suggests that the F(ab)-mediated inhibitory effect saturates with increasing drug-receptor affinity, thereby limiting the impact of increasing antibody affinity on improving the effect. This indicates that observed differences in the therapeutic effects of high affinity antibodies in the market and in clinical development may result mainly from Fc-mediated indirect mechanisms such as antibody-dependent cell cytotoxicity.}, language = {en} } @misc{Schulz2012, author = {Schulz, Michael Karl}, title = {Antony Polonsky: The Jews in Poland and Russia. - (1350 to 1881 ; 1) \ [rezensiert von] Michał Szulc}, series = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien e.V.}, journal = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien e.V.}, number = {18}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1614-6492}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-61646}, pages = {170 -- 172}, year = {2012}, abstract = {rezensiertes Werk: Antony Polonsky: The Jews in Poland and Russia. - (Bd. 1: 1350 to 1881 ; Bd. 2: 1881 to1914). - Oxford/Portland, Oregon : The Littman Library of Jewish Civilization, 2010. - 568 S. ISBN 978-1-874774-64-8}, language = {de} } @misc{DallmeyerClaussenWangetal.2012, author = {Dallmeyer, Anne and Claussen, Martin and Wang, Yongbo and Herzschuh, Ulrike}, title = {Spatial variability of Holocene changes in the annual precipitation pattern}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {905}, issn = {1866-8372}, doi = {10.25932/publishup-43277}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-432771}, pages = {20}, year = {2012}, abstract = {This study provides a detailed analysis of the mid-Holocene to present-day precipitation change in the Asian monsoon region. We compare for the first time results of high resolution climate model simulations with a standardised set of mid-Holocene moisture reconstructions. Changes in the simulated summer monsoon characteristics (onset, withdrawal, length and associated rainfall) and the mechanisms causing the Holocene precipitation changes are investigated. According to the model, most parts of the Indian subcontinent received more precipitation (up to 5 mm/day) at mid-Holocene than at present-day. This is related to a stronger Indian summer monsoon accompanied by an intensified vertically integrated moisture flux convergence. The East Asian monsoon region exhibits local inhomogeneities in the simulated annual precipitation signal. The sign of this signal depends on the balance of decreased pre-monsoon and increased monsoon precipitation at mid-Holocene compared to present-day. Hence, rainfall changes in the East Asian monsoon domain are not solely associated with modifications in the summer monsoon circulation but also depend on changes in the mid-latitudinal westerly wind system that dominates the circulation during the pre-monsoon season. The proxy-based climate reconstructions confirm the regional dissimilarities in the annual precipitation signal and agree well with the model results. Our results highlight the importance of including the pre-monsoon season in climate studies of the Asian monsoon system and point out the complex response of this system to the Holocene insolation forcing. The comparison with a coarse climate model simulation reveals that this complex response can only be resolved in high resolution simulations.}, language = {en} } @misc{AdamBovend'EerdtDoorenetal.2012, author = {Adam, Jos J. and Bovend'Eerdt, Thamar J. H. and Dooren, Fleur E. P. van and Fischer, Martin H. and Pratt, Jay}, title = {The closer the better}, series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, number = {607}, issn = {1866-8364}, doi = {10.25932/publishup-43296}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-432963}, pages = {1533 -- 1538}, year = {2012}, abstract = {A growing literature has suggested that processing of visual information presented near the hands is facilitated. In this study, we investigated whether the near-hands superiority effect also occurs with the hands moving. In two experiments, participants performed a cyclical bimanual movement task requiring concurrent visual identification of briefly presented letters. For both the static and dynamic hand conditions, the results showed improved letter recognition performance with the hands closer to the stimuli. The finding that the encoding advantage for near-hand stimuli also occurred with the hands moving suggests that the effect is regulated in real time, in accordance with the concept of a bimodal neural system that dynamically updates hand position in external space.}, language = {en} } @phdthesis{Ballnat2012, author = {Ballnat, Silvana}, title = {Das Verh{\"a}ltnis zwischen den Begriffen "Erfahrung" und "Sprache" ausgehend von Hans-Georg Gadamers "Wahrheit und Methode" : eine antireduktionistische Lesart gegen Relativismusvorw{\"u}rfe}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-176-9}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-59047}, school = {Universit{\"a}t Potsdam}, pages = {358}, year = {2012}, abstract = {Meiner nichtreduktionistischen Lesart Gadamers, derzufolge eine wechselseitige konstitutive Relation zwischen „Sprache" und „Erfahrung" besteht, ist es gestattet, den Vorwurf, die Sprachphilosophie Gadamers f{\"u}hre in den Relativismus, den man h{\"a}ufig gegen{\"u}ber sprachphilosophischen Positionen erhebt, abzuweisen. Manchen Denkern zufolge haben die Philosophen der Postmoderne, zu denen auch Gadamer gez{\"a}hlt wurde, eine einfache Umkehrung der beiden Pole des modernen Verh{\"a}ltnisses „Sprache" - „Erfahrung" vollzogen: W{\"a}hrend die Sprache in der Moderne in ihrer Bedingtheit zur Erfahrung und als bloßes Ausdrucksmittel verstanden wurde, wurde dieses Verh{\"a}ltnis in der neueren Philosophie nur umgekehrt, insofern die Philosophie in der Sprache das Fundament f{\"u}r die Erfahrung sehe, wonach die Erfahrung als ein Ausdruck der Sprache erscheine. Die vorliegende Arbeit setzt sich mit diesem Relativismusvorwurf auseinander und beabsichtigt, eine wechselseitige Abh{\"a}ngigkeit zwischen Sprache und Erfahrung ausgehend von Hans-Georg Gadamers Werk zu entwickeln. Um das zu erreichen, wurden zun{\"a}chst eine doppelte negative-positive Erfahrungsstruktur und dann einige ph{\"a}nomenologische und transzendentale Merkmale der Erfahrung auf dem historischen Hintergrund f{\"u}r Gadamers Erfahrungsbegriff herausgearbeitet. Somit machte sich die konstitutive Sprachlichkeit der Erfahrung erkennbar. In einer Auseinandersetzung mit dem Sprachbegriff auf der anderen Seite wurde sein dialogischer und welterschließender Charakter veranschaulicht, so dass auch seine Angewiesenheit auf die Welterfahrung offenkundig wurde.}, language = {de} } @article{MuehlJaeckel2012, author = {M{\"u}hl-J{\"a}ckel, Margarete}, title = {Erfahrungen mit der Privatisierung in der Praxis}, series = {KWI-Schriften}, journal = {KWI-Schriften}, number = {6}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1867-951X}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-62232}, pages = {33 -- 47}, year = {2012}, abstract = {Inhalt: I. Vorbemerkung II. Was wird privatisiert? III. Warum privatisieren Kommunen? IV. Der rechtliche Ausgangspunkt f{\"u}r Privatisierungsbestrebungen V. Ausgew{\"a}hlte Themenbereiche 1. Bundesrecht und Unternehmenssteuerung 2. Privatisierung und Vergaberecht 3. Privatisierung und Konkurrentenschutz}, language = {de} }