@article{AltenbergerMejiaJimenezGuenteretal.2012, author = {Altenberger, Uwe and Mejia Jimenez, D. M. and G{\"u}nter, C. and Sierra Rodriguez, G. I. and Scheffler, F. and Oberh{\"a}nsli, Roland}, title = {The Garzn Massif, Colombia-a new ultrahigh-temperature metamorphic complex in the early Neoproterozoic of northern South America}, series = {Mineralogy and petrology}, volume = {105}, journal = {Mineralogy and petrology}, number = {3-4}, publisher = {Springer}, address = {Wien}, issn = {0930-0708}, doi = {10.1007/s00710-012-0202-1}, pages = {171 -- 185}, year = {2012}, abstract = {The Garzn Complex of the Garzn Massif in SW Colombia is composed of the Vergel Granulite Unit (VG) and the Las Margaritas Migmatite Unit (LMM). Previous studies reveal peak temperature conditions for the VG of about 740 A degrees C. The present study considers the remarkable exsolution phenomena in feldspars and pyroxenes and titanium-in-quartz thermometry. Recalculated ternary feldspar compositions indicate temperatures around 900-1,000 A degrees C just at or above the ultra-high temperature-metamorphism (UHTM) boundary of granulites. The calculated temperatures range of exsolved ortho- and clinopyroxenes also supports the existence of an UHTM event. In addition, titanium-in-quartz thermometry points towards ultra-high temperatures. It is the first known UHTM crustal segment in the northern part of South America. Although a mean geothermal gradient of ca 38 A degrees C km(-1) could imply additional heat supply in the lower crust controlling this extreme of peak metamorphism, an alternative model is suggested. The formation of the Vergel Granulite Unit is supposed to be formed in a continental back-arc environment with a thinned and weakened crust behind a magmatic arc (Guapotn-Mancagua Gneiss) followed by collision. In contrast, rocks of the adjacent Las Margaritas Migmatite Unit display "normal" granulite facies temperatures and are formed in a colder lower crust outside the arc, preserved by the Guapotn-Mancagu Gneiss. Back-arc formation was followed by inversion and thickening of the basin. The three units that form the modern-day Garzn Massif, were juxtaposed upon each other during collision (at ca. 1,000 Ma) and exhumation. The collision leading to the deformation of the studied area is part of the Grenville orogeny leading to the amalgamation of Rodinia.}, language = {en} } @article{GoepelHoelzleKnyphausenAufsess2012, author = {G{\"o}pel, Monique and H{\"o}lzle, Katharina and Knyphausen-Aufsess, Dodo Zu}, title = {Individuals' innovation response behaviour a framework of antecedents and opportunities for future research}, series = {Creativity and innovation management}, volume = {21}, journal = {Creativity and innovation management}, number = {4}, publisher = {Wiley-Blackwell}, address = {Hoboken}, issn = {0963-1690}, doi = {10.1111/caim.12000}, pages = {412 -- 426}, year = {2012}, abstract = {Innovation response behaviour is defined as individuals novelty-supporting or novelty-impeding action when navigating innovation initiatives through the organization. A typology of innovation response behaviour is developed, distinguishing between active and passive modes of conduct for novelty-supporting and novelty-impeding behaviour, respectively. The antecedents of innovation response behaviour are delineated based on West and Farr's five-factor model of individual innovation. Moreover, we argue that within organizational contexts, individuals often fail to implement their ideas due to innovation barriers, perceived as factors that are beyond their control. Based on the theory of planned behaviour, we reveal how these barriers influence individuals intentional and exhibited innovation response behaviour. Propositions about proximal and distal antecedents of individuals innovation response behaviour are derived. Proposing a research framework to study the organizational process of innovation from an actor-based perspective, this paper intends to link existing research on individual innovation with the process of innovation at the organizational level, explicitly accounting for the socio-political dynamics and arising managerial problems associated with successful innovation implementation within organizational realities. Implications for research in innovation management are discussed and avenues for future research outlined.}, language = {en} } @inproceedings{ListekMicheelHeilmann2012, author = {Listek, Martin and Micheel, Burkhard and Heilmann, K.}, title = {Insertion of artificial cell surface receptors for antigen-specific labelling of hybridoma cells}, series = {Immunology : an official journal of the British Society for Immunology}, volume = {137}, booktitle = {Immunology : an official journal of the British Society for Immunology}, publisher = {Wiley-Blackwell}, address = {Hoboken}, issn = {0019-2805}, pages = {651 -- 651}, year = {2012}, language = {en} } @article{BorchardtTrauth2012, author = {Borchardt, Sven and Trauth, Martin H.}, title = {Remotely-sensed evapotranspiration estimates for an improved hydrological modeling of the early holocene mega-lake Suguta, northern Kenya Rift}, series = {Palaeogeography, palaeoclimatology, palaeoecology : an international journal for the geo-sciences}, volume = {361}, journal = {Palaeogeography, palaeoclimatology, palaeoecology : an international journal for the geo-sciences}, number = {22}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0031-0182}, doi = {10.1016/j.palaeo.2012.07.009}, pages = {14 -- 20}, year = {2012}, abstract = {The actual evapotranspiration is an important, but difficult to determine, element in the water balance of lakes and their catchment areas. Reliable data on evapotranspiration are not available for most lake basins for which paleoclimate reconstructions and modeling have been performed, particularly those in remote parts of Africa. We have used thermal infrared multispectral data for 14 ASTER scenes from the TERRA satellite to estimate the actual evapotranspiration in the 12,800 km(2) catchment of the Suguta Valley, northern Kenya Rift Evidence from sediments and paleo-shorelines indicates that, during the African Humid Period (AHP, 14.8 to 5.5 kyrs BP), this valley contained a large lake, 280 m deep and covering similar to 2200 km(2), which has now virtually disappeared. Evapotranspiration estimates for the Suguta Basin were generated using the Surface Energy Balance Algorithm for Land (SEBAL). Climate data required for the model were extracted from a high-resolution gridded dataset obtained from the Climatic Research Unit (East Anglia, UK). Results suggest significant spatial variations in evapotranspiration within the catchment area (ranging from 450 mm/yr in the basin to the north to 2000 mm/yr in more elevated areas) and precipitation that was similar to 20\% higher during the AHP than in recent times. These results are in agreement with other estimates of paleo-precipitation in East Africa. The extreme response of the lake system (similar to 280 m greater water depth than today, and a lake surface area of 2200 km(2)) to only moderately higher precipitation illustrates the possible sensitivity of this area to future climate change.}, language = {en} } @article{StrolloParolaiBindietal.2012, author = {Strollo, Angelo and Parolai, Stefano and Bindi, Dino and Chiauzzi, Leonardo and Pagliuca, Rossella and Mucciarelli, Marco and Zschau, Jochen}, title = {Microzonation of Potenza (Southern Italy) in terms of spectral intensity ratio using joint analysis of earthquakes and ambient noise}, series = {Bulletin of earthquake engineering : official publication of the European Association for Earthquake Engineering}, volume = {10}, journal = {Bulletin of earthquake engineering : official publication of the European Association for Earthquake Engineering}, number = {2}, publisher = {Springer}, address = {Dordrecht}, issn = {1570-761X}, doi = {10.1007/s10518-011-9256-4}, pages = {493 -- 516}, year = {2012}, abstract = {A temporary seismic network composed of 11 stations was installed in the city of Potenza (Southern Italy) to record local and regional seismicity within the context of a national project funded by the Italian Department of Civil Protection (DPC). Some stations were moved after a certain time in order to increase the number of measurement points, leading to a total of 14 sites within the city by the end of the experiment. Recordings from 26 local earthquakes (M-l 2.2-3.8 ) were analyzed to compute the site responses at the 14 sites by applying both reference and non-reference site techniques. Furthermore, the Spectral Intensity (SI) for each local earthquake, as well as their ratios with respect to the values obtained at a reference site, were also calculated. In addition, a field survey of 233 single station noise measurements within the city was carried out to increase the information available at localities different from the 14 monitoring sites. By using the results of the correlation analysis between the horizontal-to-vertical spectral ratios computed from noise recordings (NHV) at the 14 selected sites and those derived by the single station noise measurements within the town as a proxy, the spectral intensity correction factors for site amplification obtained from earthquake analysis were extended to the entire city area. This procedure allowed us to provide a microzonation map of the urban area that can be directly used when calculating risk scenarios for civil defence purposes. The amplification factors estimated following this approach show values increasing along the main valley toward east where the detrital and alluvial complexes reach their maximum thickness.}, language = {en} } @misc{MorrisSaltRailaetal.2012, author = {Morris, Penelope J. and Salt, Carina and Raila, Jens and Brenten, Thomas and Kohn, Barbara and Schweigert, Florian J. and Zentek, J{\"u}rgen}, title = {Safety evaluation of vitamin A in growing dogs}, series = {Potsprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Potsprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {686}, doi = {10.25932/publishup-41492}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-414929}, pages = {10}, year = {2012}, abstract = {The safe upper limit for inclusion of vitamin A in complete diets for growing dogs is uncertain, with the result that current recommendations range from 5.24 to 104.80 mu mol retinol (5000 to 100 000 IU vitamin A)/4184 kJ (1000 kcal) metabolisable energy (ME). The aim of the present study was to determine the effect of feeding four concentrations of vitamin A to puppies from weaning until 1 year of age. A total of forty-nine puppies, of two breeds, Labrador Retriever and Miniature Schnauzer, were randomly assigned to one of four treatment groups. Following weaning at 8 weeks of age, puppies were fed a complete food supplemented with retinyl acetate diluted in vegetable oil and fed at 1ml oil/100 g diet to achieve an intake of 5.24, 13.10, 78.60 and 104.80 mu mol retinol (5000, 12 500, 75 000 and 100 000 IU vitamin A)/4184 kJ (1000 kcal) ME. Fasted blood and urine samples were collected at 8, 10, 12, 14, 16, 20, 26, 36 and 52 weeks of age and analysed for markers of vitamin A metabolism and markers of safety including haematological and biochemical variables, bone-specific alkaline phosphatase, cross-linked carboxyterminal telopeptides of type I collagen and dual-energy X-ray absorptiometry. Clinical examinations were conducted every 4 weeks. Data were analysed by means of a mixed model analysis with Bonferroni corrections for multiple endpoints. There was no effect of vitamin A concentration on any of the parameters, with the exception of total serum retinyl esters, and no effect of dose on the number, type and duration of adverse events. We therefore propose that 104.80 mu mol retinol (100 000 IU vitamin A)/4184 kJ (1000 kcal) is a suitable safe upper limit for use in the formulation of diets designed for puppy growth.}, language = {en} } @misc{CaliendoHogenacker2012, author = {Caliendo, Marco and Hogenacker, Jens}, title = {The German labor market after the Great Recession}, series = {Postprints der Universit{\"a}t Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe}, number = {129}, issn = {1867-5808}, doi = {10.25932/publishup-43519}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-435195}, pages = {26}, year = {2012}, abstract = {The reaction of the German labor market to the Great Recession 2008/09 was relatively mild - especially compared to other countries. The reason lies not only in the specific type of the recession - which was favorable for the German economy structure - but also in a series of labor market reforms initiated between 2002 and 2005 altering, inter alia, labor supply incentives. However, irrespective of the mild response to the Great Recession, there are a number of substantial future challenges the German labor market will soon have to face. Female labor supply still lies well below that of other countries and a massive demographic change over the next 50 years will have substantial effects on labor supply as well as the pension system. In addition, due to a skill-biased technological change over the next decades, firms will face problems of finding employees with adequate skills. The aim of this paper is threefold. First, we outline why the German labor market reacted in such a mild fashion, describe current economic trends of the labor market in light of general trends in the European Union, and reveal some of the main associated challenges. Thereafter, the paper analyzes recent reforms of the main institutional settings of the labor market which influence labor supply. Finally, based on the status quo of these institutional settings, the paper gives a brief overview of strategies to combat adequately the challenges in terms of labor supply and to ensure economic growth in the future.}, language = {en} } @misc{KleessenNikoloski2012, author = {Kleessen, Sabrina and Nikoloski, Zoran}, title = {Dynamic regulatory on/off minimization for biological systems under internal temporal perturbations}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe}, number = {852}, issn = {1866-8372}, doi = {10.25932/publishup-43112}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-431128}, pages = {15}, year = {2012}, abstract = {Background: Flux balance analysis (FBA) together with its extension, dynamic FBA, have proven instrumental for analyzing the robustness and dynamics of metabolic networks by employing only the stoichiometry of the included reactions coupled with adequately chosen objective function. In addition, under the assumption of minimization of metabolic adjustment, dynamic FBA has recently been employed to analyze the transition between metabolic states. Results: Here, we propose a suite of novel methods for analyzing the dynamics of (internally perturbed) metabolic networks and for quantifying their robustness with limited knowledge of kinetic parameters. Following the biochemically meaningful premise that metabolite concentrations exhibit smooth temporal changes, the proposed methods rely on minimizing the significant fluctuations of metabolic profiles to predict the time-resolved metabolic state, characterized by both fluxes and concentrations. By conducting a comparative analysis with a kinetic model of the Calvin-Benson cycle and a model of plant carbohydrate metabolism, we demonstrate that the principle of regulatory on/off minimization coupled with dynamic FBA can accurately predict the changes in metabolic states. Conclusions: Our methods outperform the existing dynamic FBA-based modeling alternatives, and could help in revealing the mechanisms for maintaining robustness of dynamic processes in metabolic networks over time.}, language = {en} } @misc{KrippendorffOyarzunHuisinga2012, author = {Krippendorff, Ben-Fillippo and Oyarz{\´u}n, Diego A. and Huisinga, Wilhelm}, title = {Predicting the F(ab)-mediated effect of monoclonal antibodies in vivo by combining cell-level kinetic and pharmacokinetic modelling}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {958}, issn = {1866-8372}, doi = {10.25932/publishup-43105}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-431051}, pages = {125 -- 139}, year = {2012}, abstract = {Cell-level kinetic models for therapeutically relevant processes increasingly benefit the early stages of drug development. Later stages of the drug development processes, however, rely on pharmacokinetic compartment models while cell-level dynamics are typically neglected. We here present a systematic approach to integrate cell-level kinetic models and pharmacokinetic compartment models. Incorporating target dynamics into pharmacokinetic models is especially useful for the development of therapeutic antibodies because their effect and pharmacokinetics are inherently interdependent. The approach is illustrated by analysing the F(ab)-mediated inhibitory effect of therapeutic antibodies targeting the epidermal growth factor receptor. We build a multi-level model for anti-EGFR antibodies by combining a systems biology model with in vitro determined parameters and a pharmacokinetic model based on in vivo pharmacokinetic data. Using this model, we investigated in silico the impact of biochemical properties of anti-EGFR antibodies on their F(ab)-mediated inhibitory effect. The multi-level model suggests that the F(ab)-mediated inhibitory effect saturates with increasing drug-receptor affinity, thereby limiting the impact of increasing antibody affinity on improving the effect. This indicates that observed differences in the therapeutic effects of high affinity antibodies in the market and in clinical development may result mainly from Fc-mediated indirect mechanisms such as antibody-dependent cell cytotoxicity.}, language = {en} } @unpublished{LaubrockHohenstein2012, author = {Laubrock, Jochen and Hohenstein, Sven}, title = {Orthographic consistency and parafoveal preview benefit: A resource-sharing account of language differences in processing of phonological and semantic codes}, series = {Behavioral and brain sciences : an international journal of current research and theory with open peer commentary}, volume = {35}, journal = {Behavioral and brain sciences : an international journal of current research and theory with open peer commentary}, number = {5}, publisher = {Cambridge Univ. Press}, address = {New York}, issn = {0140-525X}, doi = {10.1017/S0140525X12000209}, pages = {292 -- 293}, year = {2012}, abstract = {Parafoveal preview benefit (PB) is an implicit measure of lexical activation in reading. PB has been demonstrated for orthographic and phonological but not for semantically related information in English. In contrast, semantic PB is obtained in German and Chinese. We propose that these language differences reveal differential resource demands and timing of phonological and semantic decoding in different orthographic systems.}, language = {en} }