@article{Jung2021,
  author    = {Jung, Jana},
  title     = {Does youth matter?},
  series = {Longitudinal and life course studies : LLCS ; international journal / Society for Longitudinal and Life Course Studies},
  volume    = {12},
  journal   = {Longitudinal and life course studies : LLCS ; international journal / Society for Longitudinal and Life Course Studies},
  number    = {2},
  publisher = {Longview},
  address   = {London},
  issn      = {1757-9597},
  doi       = {10.1332/175795920X15980339169308},
  pages     = {201 -- 225},
  year      = {2021},
  abstract  = {Previous research has mainly concentrated on the study of certain transitions and the influence of economic and socio-structural factors on partnership status. From a life course perspective, it remains unclear how factors anchored in youth are related to the diversity of partnership biographies. Arguing that individuals act and behave based on prior experiences and resources, I analyse how personal and social resources as well as socio-demographic characteristics influence the turbulence of longitudinal partnership trajectories. Using a longitudinal dataset from the German LifE Study, I examine partnership histories from the ages 16 to 45. The results suggest that in addition to the influence of an individual's socio-demographic placement (for example, religious commitment and regional living conditions), personal and social resources anchored in youth also have a long-term effect on the diversity of partnership trajectories. This article shows that women are influenced by their attitudes towards marriage and family, while men are influenced by their attitudes towards their careers.},
  language  = {en}
}
@misc{HessSaffertLiebetonetal.2015,
  author    = {Hess, Anne-Katrin and Saffert, Paul and Liebeton, Klaus and Ignatova, Zoya},
  title     = {Optimization of translation profiles enhances protein expression and solubility},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {518},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-40957},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-409574},
  pages     = {14},
  year      = {2015},
  abstract  = {mRNA is translated with a non-uniform speed that actively coordinates co-translational folding of protein domains. Using structure-based homology we identified the structural domains in epoxide hydrolases (EHs) and introduced slow-translating codons to delineate the translation of single domains. These changes in translation speed dramatically improved the solubility of two EHs of metagenomic origin in Escherichia coli. Conversely, the importance of transient attenuation for the folding, and consequently solubility, of EH was evidenced with a member of the EH family from Agrobacterium radiobacter, which partitions in the soluble fraction when expressed in E. coli. Synonymous substitutions of codons shaping the slow-transiting regions to fast-translating codons render this protein insoluble. Furthermore, we show that low protein yield can be enhanced by decreasing the free folding energy of the initial 5'-coding region, which can disrupt mRNA secondary structure and enhance ribosomal loading. This study provides direct experimental evidence that mRNA is not a mere messenger for translation of codons into amino acids but bears an additional layer of information for folding, solubility and expression level of the encoded protein. Furthermore, it provides a general frame on how to modulate and fine-tune gene expression of a target protein.},
  language  = {en}
}
@misc{GambaJonesTeasdaleetal.2014,
  author    = {Gamba, Cristina and Jones, Eppie R. and Teasdale, Matthew D. and McLaughlin, Russell L. and Gonz{\´a}lez-Fortes, Gloria M. and Mattiangeli, Valeria and Dombor{\´o}czki, L{\´a}szl{\´o} and Kőv{\´a}ri, Ivett and Pap, Ildik{\´o} and Anders, Alexandra and Whittle, Alasdair and Dani, J{\´a}nos and Raczky, P{\´a}l and Higham, Thomas F. G. and Hofreiter, Michael and Bradley, Daniel G. and Pinhasi, Ron},
  title     = {Genome flux and stasis in a five millennium transect of European prehistory},
  series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  volume    = {5},
  journal   = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {1332},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-43799},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-437999},
  pages     = {9},
  year      = {2014},
  abstract  = {The Great Hungarian Plain was a crossroads of cultural transformations that have shaped European prehistory. Here we analyse a 5,000-year transect of human genomes, sampled from petrous bones giving consistently excellent endogenous DNA yields, from 13 Hungarian Neolithic, Copper, Bronze and Iron Age burials including two to high (similar to 22x) and seven to similar to 1x coverage, to investigate the impact of these on Europe's genetic landscape. These data suggest genomic shifts with the advent of the Neolithic, Bronze and Iron Ages, with interleaved periods of genome stability. The earliest Neolithic context genome shows a European hunter-gatherer genetic signature and a restricted ancestral population size, suggesting direct contact between cultures after the arrival of the first farmers into Europe. The latest, Iron Age, sample reveals an eastern genomic influence concordant with introduced Steppe burial rites. We observe transition towards lighter pigmentation and surprisingly, no Neolithic presence of lactase persistence.},
  language  = {en}
}
@misc{GallegoLlorenteSarahJonesetal.2016,
  author    = {Gallego-Llorente, Marcos and Sarah, Connell and Jones, Eppie R. and Merrett, Deborah C. and Jeon, Y. and Eriksson, Anders and Siska, Veronika and Gamba, Cristina and Meiklejohn, Christopher and Beyer, Robert and Jeon, Sungwon and Cho, Yun Sung and Hofreiter, Michael and Bhak, Jong and Manica, Andrea and Pinhasi, Ron},
  title     = {The genetics of an early Neolithic pastoralist from the Zagros, Iran},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {952},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-43935},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-439355},
  pages     = {9},
  year      = {2016},
  abstract  = {The agricultural transition profoundly changed human societies. We sequenced and analysed the first genome (1.39x) of an early Neolithic woman from Ganj Dareh, in the Zagros Mountains of Iran, a site with early evidence for an economy based on goat herding, ca. 10,000 BP. We show that Western Iran was inhabited by a population genetically most similar to hunter-gatherers from the Caucasus, but distinct from the Neolithic Anatolian people who later brought food production into Europe. The inhabitants of Ganj Dareh made little direct genetic contribution to modern European populations, suggesting those of the Central Zagros were somewhat isolated from other populations of the Fertile Crescent. Runs of homozygosity are of a similar length to those from Neolithic farmers, and shorter than those of Caucasus and Western Hunter-Gatherers, suggesting that the inhabitants of Ganj Dareh did not undergo the large population bottleneck suffered by their northern neighbours. While some degree of cultural diffusion between Anatolia, Western Iran and other neighbouring regions is possible, the genetic dissimilarity between early Anatolian farmers and the inhabitants of Ganj Dareh supports a model in which Neolithic societies in these areas were distinct.},
  language  = {en}
}