@misc{MutludeEspinosaMeier2011, author = {Mutlu, Hatice and de Espinosa, Lucas Montero and Meier, Michael A. R.}, title = {Acyclic diene metathesis a versatile tool for the construction of defined polymer architectures}, series = {Chemical Society reviews}, volume = {40}, journal = {Chemical Society reviews}, number = {3}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {0306-0012}, doi = {10.1039/b924852h}, pages = {1404 -- 1445}, year = {2011}, abstract = {Two decades have passed since the metathesis polymerisation of alpha,omega-dienes was successfully demonstrated by the group of Wagener and the term acyclic diene metathesis (ADMET) polymerisation was coined. Since then, the advances of metathesis chemistry have allowed to expand the scope of this versatile polymerisation reaction that nowadays finds applications in different fields, such as polymer, material, or medicinal chemistry. This critical review provides an insight into the historical aspects of ADMET and a detailed overview of the work done to date applying this versatile polymerisation reaction (221 references).}, language = {en} } @misc{KitaTokarczykJungingerBelegrinouetal.2011, author = {Kita-Tokarczyk, Katarzyna and Junginger, Mathias and Belegrinou, Serena and Taubert, Andreas}, title = {Amphiphilic polymers at interfaces}, series = {Advances in polymer science}, volume = {242}, journal = {Advances in polymer science}, number = {1}, editor = {Muller, AHE and Borisov, O}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-642-22297-9}, issn = {0065-3195}, doi = {10.1007/12_2010_58}, pages = {151 -- 201}, year = {2011}, abstract = {Self-assembly phenomena in block copolymer systems are attracting considerable interest from the scientific community and industry alike. Particularly interesting is the behavior of amphiphilic copolymers, which can self-organize into nanoscale-sized objects such as micelles, vesicles, or tubes in solution, and which form well-defined assemblies at interfaces such as air-liquid, air-solid, or liquid-solid. Depending on the polymer chemistry and architecture, various types of organization at interfaces can be expected, and further exploited for applications in nanotechnology, electronics, and biomedical sciences. In this article, we discuss the formation and characterization of Langmuir monolayers from various amphiphilic block copolymers, including chargeable and thus pH-responsivematerials. Solid-supported polymer films are reviewed in the context of alteration of surface properties by ultrathin polymer layers and the possibilities for application in tissue engineering, sensors and biomaterials. Finally, we focus on how organic and polymer monolayers influence the growth of inorganic materials. This is a truly biomimetic approach since Nature uses soft interfaces to control the nucleation, growth, and morphology of biominerals such as calcium phosphate, calcium carbonate, and silica.}, language = {en} } @misc{HeckMichaeliBaldetal.2018, author = {Heck, Christian and Michaeli, Yael and Bald, Ilko and Ebenstein, Yuval}, title = {Analytical epigenetics}, series = {Current Opinion in Biotechnology}, volume = {55}, journal = {Current Opinion in Biotechnology}, publisher = {Elsevier}, address = {London}, issn = {0958-1669}, doi = {10.1016/j.copbio.2018.09.006}, pages = {151 -- 158}, year = {2018}, abstract = {The field of epigenetics describes the relationship between genotype and phenotype, by regulating gene expression without changing the canonical base sequence of DNA. It deals with molecular genomic information that is encoded by a rich repertoire of chemical modifications and molecular interactions. This regulation involves DNA, RNA and proteins that are enzymatically tagged with small molecular groups that alter their physical and chemical properties. It is now clear that epigenetic alterations are involved in development and disease, and thus, are the focus of intensive research. The ability to record epigenetic changes and quantify them in rare medical samples is critical for next generation diagnostics. Optical detection offers the ultimate single-molecule sensitivity and the potential for spectral multiplexing. Here we review recent progress in ultrasensitive optical detection of DNA and histone modifications.}, language = {en} } @misc{SuriyanarayananCywinskiMoroetal.2012, author = {Suriyanarayanan, Subramanian and Cywinski, Piotr J. and Moro, Artur J. and Mohr, Gerhard J. and Kutner, Wlodzimierz}, title = {Chemosensors based on molecularly imprinted polymers}, series = {Topics in current chemistry}, volume = {325}, journal = {Topics in current chemistry}, number = {4}, editor = {Haupt, K}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-642-28421-2}, issn = {0340-1022}, doi = {10.1007/128_2010_92}, pages = {165 -- 265}, year = {2012}, language = {en} } @misc{UnuabonahTaubert2014, author = {Unuabonah, Emmanuel Iyayi and Taubert, Andreas}, title = {Clay-polymer nanocomposites (CPNs): Adsorbents of the future for water treatment}, series = {Applied clay science : an international journal on the application and technology of clays and clay minerals}, volume = {99}, journal = {Applied clay science : an international journal on the application and technology of clays and clay minerals}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0169-1317}, doi = {10.1016/j.clay.2014.06.016}, pages = {83 -- 92}, year = {2014}, abstract = {A class of adsorbents currently receiving growing attention is the clay-polymer nanocomposite (CPN) adsorbents. CPNs effectively treat water by adsorption and flocculation of both inorganic and organic micropollutants from aqueous solutions. Some of these CPNs - when modified with biocides - also have the ability to efficiently remove microorganisms such as Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans from water. CPNs are far more easily recovered from aqueous media than neat clay. They also exhibit far better treatment times than either polymer or clay adsorbents. They have higher adsorption capacity and better life cycles compared with clay alone. CPNs therefore show an excellent potential as highly efficient water and waste treatment agents. This article reviews the various CPNs that have been prepared recently and used as adsorbents in the removal of micropollutants (inorganic, organic and biological) from aqueous solutions. A special focus is placed on CPNs that are not only interesting from an academic point of view but also effectively reduce the concentration of micropollutants in water to safe limits and also on new developments bordering on CPN use as water treatment agent that have not yet realized their full potential. (C) 2014 Elsevier B.V. All rights reserved.}, language = {en} } @misc{MotaCoelhoLeimkuehleretal.2018, author = {Mota, Cristiano and Coelho, Catarina and Leimk{\"u}hler, Silke and Garattini, Enrico and Terao, Mineko and Santos-Silva, Teresa and Romao, Maria Joao}, title = {Critical overview on the structure and metabolism of human aldehyde oxidase and its role in pharmacokinetics}, series = {Coordination chemistry reviews}, volume = {368}, journal = {Coordination chemistry reviews}, publisher = {Elsevier}, address = {Lausanne}, issn = {0010-8545}, doi = {10.1016/j.ccr.2018.04.006}, pages = {35 -- 59}, year = {2018}, abstract = {Aldehyde oxidases are molybdenum and flavin dependent enzymes characterized by a very wide substrate specificity and performing diverse reactions that include oxidations (e.g., aldehydes and azaheterocycles), hydrolysis of amide bonds, and reductions (e.g., nitro, S-oxides and N-oxides). Oxidation reactions and amide hydrolysis occur at the molybdenum site while the reductions are proposed to occur at the flavin site. AOX activity affects the metabolism of different drugs and xenobiotics, some of which designed to resist other liver metabolizing enzymes (e.g., cytochrome P450 monooxygenase isoenzymes), raising its importance in drug development. This work consists of a comprehensive overview on aldehyde oxidases, concerning the genetic evolution of AOX, its diversity among the human population, the crystal structures available, the known catalytic reactions and the consequences in pre-clinical pharmacokinetic and pharmacodynamic studies. Analysis of the different animal models generally used for pre-clinical trials and comparison between the human (hAOX1), mouse homologs as well as the related xanthine oxidase (XOR) are extensively considered. The data reviewed also include a systematic analysis of representative classes of molecules that are hAOX1 substrates as well as of typical and well characterized hAOX1 inhibitors. The considerations made on the basis of a structural and functional analysis are correlated with reported kinetic and metabolic data for typical classes of drugs, searching for potential structural determinants that may dictate substrate and/or inhibitor specificities.}, language = {en} } @misc{YarmanKurbanogluJetzschmannetal.2018, author = {Yarman, Aysu and Kurbanoglu, Sevinc and Jetzschmann, Katharina J. and Ozkan, Sibel A. and Wollenberger, Ulla and Scheller, Frieder W.}, title = {Electrochemical MIP-Sensors for Drugs}, series = {Current Medicinal Chemistry}, volume = {25}, journal = {Current Medicinal Chemistry}, number = {33}, publisher = {Bentham Science Publishers LTD}, address = {Sharjah}, issn = {0929-8673}, doi = {10.2174/0929867324666171005103712}, pages = {4007 -- 4019}, year = {2018}, abstract = {In order to replace bio-macromolecules by stable synthetic materials in separation techniques and bioanalysis biomimetic receptors and catalysts have been developed: Functional monomers are polymerized together with the target analyte and after template removal cavities are formed in the "molecularly imprinted polymer" (MIP) which resemble the active sites of antibodies and enzymes. Starting almost 80 years ago, around 1,100 papers on MIPs were published in 2016. Electropolymerization allows to deposit MIPs directly on voltammetric electrodes or chips for quartz crystal microbalance (QCM) and surface plasmon resonance (SPR). For the readout of MIPs for drugs amperometry, differential pulse voltammetry (DPV) and impedance spectroscopy (EIS) offer higher sensitivity as compared with QCM or SPR. Application of simple electrochemical devices allows both the reproducible preparation of MIP sensors, but also the sensitive signal generation. Electrochemical MIP-sensors for the whole arsenal of drugs, e.g. the most frequently used analgesics, antibiotics and anticancer drugs have been presented in literature and tested under laboratory conditions. These biomimetic sensors typically have measuring ranges covering the lower nano-up to millimolar concentration range and they are stable under extreme pH and in organic solvents like nonaqueous extracts.}, language = {en} } @misc{Taubert2015, author = {Taubert, Andreas}, title = {Electrospinning of Ionogels: Current Status and Future Perspectives}, series = {European journal of inorganic chemistry : a journal of ChemPubSoc Europe}, journal = {European journal of inorganic chemistry : a journal of ChemPubSoc Europe}, number = {7}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1434-1948}, doi = {10.1002/ejic.201402490}, pages = {1148 -- 1159}, year = {2015}, abstract = {Ionogels (IGs), also termed ion gels, are functional hybrid materials based on an ionic liquid (IL) and a polymeric, hybrid, or inorganic matrix. IGs combine the properties of the matrix such as mechanical strength with IL properties like high ionic conductivity, high thermal stability, or catalytic activity. IGs are thus attractive for many applications, but the vast majority of IGs made and published so far are bulk materials or dense films. Applications like sensing or catalysis, however, would benefit from IGs with high surface areas or defined surface morphologies or architectures. In spite of this, only relatively few examples of high-surface-area IGs have been made so far; this has mostly been achieved by electrospinning, which has proven to be a promising strategy towards advanced IGs. The current review discusses first developments and outlines the future potential of electrospun ionogels, predominantly from a materials and inorganic chemistry perspective.}, language = {en} } @misc{SchoeneRochSchulzetal.2017, author = {Sch{\"o}ne, Anne-Christin and Roch, Toralf and Schulz, Burkhard and Lendlein, Andreas}, title = {Evaluating polymeric biomaterial-environment interfaces by Langmuir monolayer techniques}, series = {Interface : journal of the Royal Society}, volume = {14}, journal = {Interface : journal of the Royal Society}, publisher = {Royal Society}, address = {London}, issn = {1742-5689}, doi = {10.1098/rsif.2016.1028}, pages = {18}, year = {2017}, abstract = {Polymeric biomaterials are of specific relevance in medical and pharmaceutical applications due to their wide range of tailorable properties and functionalities. The knowledge about interactions of biomaterials with their biological environment is of crucial importance for developing highly sophisticated medical devices. To achieve optimal in vivo performance, a description at the molecular level is required to gain better understanding about the surface of synthetic materials for tailoring their properties. This is still challenging and requires the comprehensive characterization of morphological structures, polymer chain arrangements and degradation behaviour. The review discusses selected aspects for evaluating polymeric biomaterial-environment interfaces by Langmuir monolayer methods as powerful techniques for studying interfacial properties, such as morphological and degradation processes. The combination of spectroscopic, microscopic and scattering methods with the Langmuir techniques adapted to polymers can substantially improve the understanding of their in vivo behaviour.}, language = {en} } @misc{BandraukParamonov2014, author = {Bandrauk, Andre D. and Paramonov, Guennaddi K.}, title = {Excitation of muonic molecules dd mu and dt mu by super-intense attosecond soft X-ray laser pulses: Shaped post-laser-pulse muonic oscillations and enhancement of nuclear fusion}, series = {International journal of modern physics : E, Nuclear physics}, volume = {23}, journal = {International journal of modern physics : E, Nuclear physics}, number = {9}, publisher = {World Scientific}, address = {Singapore}, issn = {0218-3013}, doi = {10.1142/S0218301314300148}, pages = {34}, year = {2014}, abstract = {The quantum dynamics of muonic molecular ions dd mu and dt mu excited by linearly polarized along the molecular (z)-axis super-intense laser pulses is studied beyond the Born-Oppenheimer approximation by the numerical solution of the time-dependent Schrodinger equation within a three-dimensional model, including the internuclear distance R and muon coordinates z and rho. The peak-intensity of the super-intense laser pulses used in our simulations is I-0 = 3.51 x 10(22) W/cm(2) and the wavelength is lambda(l) = 5nm. In both dd mu and dt mu, expectation values < z > and of muon demonstrate "post-laser-pulse" oscillations after the ends of the laser pulses. In dd mu post-laser-pulse z-oscillations appear as shaped nonoverlapping "echo-pulses". In dt mu post-laser-pulse muonic z-oscillations appear as comparatively slow large-amplitude oscillations modulated with small-amplitude pulsations. The post-laser-pulse rho-oscillations in both dd mu and dt mu appear, for the most part, as overlapping "echo-pulses". The post-laser-pulse oscillations do not occur if the Born-Oppenheimer approximation is employed. Power spectra generated due to muonic motion along both optically active z and optically passive rho degrees of freedom are calculated. The fusion probability in dt mu can be increased by more than 11 times by making use of three sequential super-intense laser pulses. The energy released from the dt fusion in dt mu can by more than 20 GeV exceed the energy required to produce a usable muon and the energy of the laser pulses used to enhance the fusion. The possibility of power production from the laser-enhanced muon-catalyzed fusion is discussed.}, language = {en} }