@article{BuyinzaDereseNdakalaetal.2021,
  author    = {Buyinza, Daniel and Derese, Solomon and Ndakala, Albert and Heydenreich, Matthias and Yenesew, Abiy and Koch, Andreas and Oriko, Richard},
  title     = {A coumestan and a coumaronochromone from Millettia lasiantha},
  series = {Biochemical systematics and ecology},
  volume    = {97},
  journal   = {Biochemical systematics and ecology},
  publisher = {Elsevier},
  address   = {Oxford},
  issn      = {0305-1978},
  doi       = {10.1016/j.bse.2021.104277},
  pages     = {5},
  year      = {2021},
  abstract  = {The manuscript describes the phytochemical investigation of the roots, leaves and stem bark of Millettia lasiantha resulting in the isolation of twelve compounds including two new isomeric isoflavones lascoumestan and las-coumaronochromone. The structures of the new compounds were determined using different spectroscopic techniques.},
  language  = {en}
}
@article{KleinpeterHeydenreichShainyan2021,
  author    = {Kleinpeter, Erich and Heydenreich, Matthias and Shainyan, Bagrat A.},
  title     = {At the experimental limit of the NMR conformational analysis},
  series = {Organic letters},
  volume    = {23},
  journal   = {Organic letters},
  number    = {2},
  publisher = {American Chemical Society},
  address   = {Washington},
  issn      = {1523-7060},
  doi       = {10.1021/acs.orglett.0c03878},
  pages     = {405 -- 409},
  year      = {2021},
  abstract  = {The low temperature (95 K) NMR study of 1-Ph-1-t-Bu-silacyclohexane (1) showed the conformational equilibrium to be extremely one-sided toward thePh(ax),t-Bueq conformer. The barrier to interconversion has been measured (4.2-4.6 kcal/mol) and the conformational equilibrium [Delta nu = 1990.64 ppm (Si-29), 618.9 ppm (C-13), 1-Ph-ax:1-Pheq = (95.6-96.6\%):(3.4-4.4\%), K = 25 +/- 3, Delta G degrees = -RT ln K = 0.58-0.63 kcal/mol] analyzed. The assignment and quantification of the NMR signals is supported by MP2 and DFT calculations.},
  language  = {en}
}
@article{MawireMozirandiHeydenreichetal.2021,
  author    = {Mawire, Phillip and Mozirandi, Winnie and Heydenreich, Matthias and Chi, Godloves Fru and Mukanganyama, Stanley},
  title     = {Isolation and antimicrobial activities of phytochemicals from Parinari curatellifolia (Chrysobalanaceae)},
  series = {Advances in pharmacological and pharmaceutical sciences},
  journal   = {Advances in pharmacological and pharmaceutical sciences},
  publisher = {Hindawi},
  address   = {London},
  issn      = {2633-4682},
  doi       = {10.1155/2021/8842629},
  pages     = {18},
  year      = {2021},
  abstract  = {The widespread use of antimicrobial agents to treat infectious diseases has led to the emergence of antibiotic resistant pathogens. Plants have played a central role in combating many ailments in humans, and Parinari curatellifolia has been used for medicinal purposes. Seven extracts from P. curatellifolia leaves were prepared using serial exhaustive extraction of nonpolar to polar solvents. The microbroth dilution method was used to evaluate antimicrobial bioactivities of extracts. Five of the extracts were significantly active against at least one test microbe. Mycobacterium smegmatis was the most susceptible to most extracts. The methanol and ethanol extracts were the most active against M. smegmatis with an MIC of 25 mu g/mL. The hexane extract was the most active against Candida krusei with an MIC of 25 mu g/mL. None of the extracts significantly inhibited growth of Klebsiella pneumoniae and Staphylococcus aureus. Active extracts were selected for fractionation and isolation of pure compounds using gradient elution column chromatography. TLC analyses was carried out for pooling fractions of similar profiles. A total of 43 pools were obtained from 428 fractions. Pools 7 and 10 were selected for further isolation of single compounds. Four compounds, Pc4963r, Pc4962w, Pc6978p, and Pc6978o, were isolated. Evaluation of antimicrobial activities of Pc4963r, Pc4962w, and Pc6978p showed that the compounds were most active against C. krusei with MFC values ranging from 50 to 100 mu g/mL. Only Pc6978p was shown to be pure. Using spectroscopic analyses, the structure of Pc6978p was determined to be beta-sitosterol. The antifungal effects of beta-sitosterol were evaluated against C. krusei in vitro and on fabrics. Results showed that beta-sitosterol reduced the growth of C. krusei attached to Mendy fabric by 83\%. Therefore, P. curatellifolia can be a source of lead compounds for prospective development of novel antimicrobial agents. Further work needs to be done to improve the antifungal activity of the isolated compound using quantitative structure-activity relationships.},
  language  = {en}
}
@article{OloyaNamukobeHeydenreichetal.2021,
  author    = {Oloya, Benson and Namukobe, Jane and Heydenreich, Matthias and Ssengooba, Willy and Schmidt, Bernd and Byamukama, Robert},
  title     = {Antimycobacterial activity of the extract and isolated compounds from the stem bark of Zanthoxylum leprieurii Guill. and Perr.},
  series = {Natural product communications : an international journal for communications and reviews},
  volume    = {16},
  journal   = {Natural product communications : an international journal for communications and reviews},
  number    = {8},
  publisher = {Sage Publ.},
  address   = {Thousand Oaks},
  issn      = {1934-578X},
  doi       = {10.1177/1934578X211035851},
  pages     = {8},
  year      = {2021},
  abstract  = {Zanthoxylum leprieurii Guill. and Perr. (Rutaceae) stem bark is used locally in Uganda for treating tuberculosis (TB) and cough-related infections. Lupeol (1), sesamin (2), trans-fagaramide (3), arnottianamide (4), (S)-marmesinin (5), and hesperidin (6) were isolated from the chloroform/methanol (1:1) extract of Z. leprieurii stem bark. Their structures were elucidated using spectroscopic techniques and by comparison with literature data. Furthermore, the extract and isolated compounds were subjected to antimycobacterial activity. The extract exhibited moderate activity against the susceptible (H(37)Rv) TB strain, but weak activity against the multidrug resistant (MDR)-TB strain with minimum inhibitory concentrations (MICs) of 586.0 and 1172.0 mu g/mL, respectively. Compound 3 (trans-fagaramide) showed significant antimycobacterial activity against the susceptible (H(37)Rv) TB strain (MIC 6 mu g/mL), but moderate activity against the MDR-TB strain (MIC 12.2 mu g/mL). Compounds 2, 5, 6, and 1 showed moderate activities against the susceptible (H(37)Rv) strain (MIC 12.2-98.0 mu g/mL) and moderate to weak activities against the MDR-TB strain (MIC 24.4-195.0 mu g/mL). This study reports for the first time the isolation of compounds 1 to 6 from the stem bark of Z leprieurii. trans-Fagaramide (3) may present a vital template in pursuit of novel and highly effective TB drugs.},
  language  = {en}
}