@article{RottlerVormoorFranckeetal.2021, author = {Rottler, Erwin and Vormoor, Klaus Josef and Francke, Till and Bronstert, Axel}, title = {Hydro Explorer}, series = {River research and applications}, volume = {37}, journal = {River research and applications}, number = {4}, publisher = {Wiley}, address = {New York}, issn = {1535-1459}, doi = {10.1002/rra.3772}, pages = {544 -- 554}, year = {2021}, abstract = {Climatic changes and anthropogenic modifications of the river basin or river network have the potential to fundamentally alter river runoff. In the framework of this study, we aim to analyze and present historic changes in runoff timing and runoff seasonality observed at river gauges all over the world. In this regard, we develop the Hydro Explorer, an interactive web app, which enables the investigation of >7,000 daily resolution discharge time series from the Global Runoff Data Centre (GRDC). The interactive nature of the developed web app allows for a quick comparison of gauges, regions, methods, and time frames. We illustrate the available analytical tools by investigating changes in runoff timing and runoff seasonality in the Rhine River Basin. Since we provide the source code of the application, existing analytical approaches can be modified, new methods added, and the tool framework can be re-used to visualize other data sets.}, language = {en} } @article{KrausMathewStephenSchapranow2021, author = {Kraus, Sara Milena and Mathew-Stephen, Mariet and Schapranow, Matthieu-Patrick}, title = {Eatomics}, series = {Journal of proteome research}, volume = {20}, journal = {Journal of proteome research}, number = {1}, publisher = {American Chemical Society}, address = {Washington}, issn = {1535-3893}, doi = {10.1021/acs.jproteome.0c00398}, pages = {1070 -- 1078}, year = {2021}, abstract = {Quantitative proteomics data are becoming increasingly more available, and as a consequence are being analyzed and interpreted by a larger group of users. However, many of these users have less programming experience. Furthermore, experimental designs and setups are getting more complicated, especially when tissue biopsies are analyzed. Luckily, the proteomics community has already established some best practices on how to conduct quality control, differential abundance analysis and enrichment analysis. However, an easy-to-use application that wraps together all steps for the exploration and flexible analysis of quantitative proteomics data is not yet available. For Eatomics, we utilize the R Shiny framework to implement carefully chosen parts of established analysis workflows to (i) make them accessible in a user-friendly way, (ii) add a multitude of interactive exploration possibilities, and (iii) develop a unique experimental design setup module, which interactively translates a given research hypothesis into a differential abundance and enrichment analysis formula. In this, we aim to fulfill the needs of a growing group of inexperienced quantitative proteomics data analysts. Eatomics may be tested with demo data directly online via https://we.analyzegenomes.com/now/eatomics/or with the user's own data by installation from the Github repository at https://github.com/Millchmaedchen/Eatomics.}, language = {en} }