@article{GienowWolff1997, author = {Gienow, Wilfried and Wolff, Dieter}, title = {Lernertexte und Lernwerkzeuge im prozeßorientierten Englischunterricht : Anmerkungen zum Anliegen der Sektion "Prozeßorientierte Medienpraxis"}, year = {1997}, language = {de} } @article{GienowHellwig1998, author = {Gienow, Wilfried and Hellwig, Karlheinz}, title = {Medien prozeßorientierter Sprachbegegnung}, year = {1998}, language = {de} } @article{GienowHellwig1997, author = {Gienow, Wilfried and Hellwig, Karlheinz}, title = {Prozeßorientierung als subjekt- und medienbezogenes Konzept : Sprach- und Sinnbildung im neusprachlichen Unterricht}, year = {1997}, language = {de} } @article{GienowHellwig1996, author = {Gienow, Wilfried and Hellwig, Karlheinz}, title = {Sprach- und Sprachbildtexte als Anregung zu spiel-handelndem Sprechen}, year = {1996}, language = {de} } @article{GienowHellwig1996, author = {Gienow, Wilfried and Hellwig, Karlheinz}, title = {Prozeßorientierung - ein integratives fremdsprachendidaktisches Konzept}, year = {1996}, language = {de} } @article{GienowHellwig1993, author = {Gienow, Wilfried and Hellwig, Karlheinz}, title = {Prozeßorientierte Mediendidaktik f{\"u}r den Fremdsprachenunterricht}, year = {1993}, language = {de} } @article{Gienow1998, author = {Gienow, Wilfried}, title = {Medien im modernen Fremdsprachenunterricht}, year = {1998}, language = {de} } @article{Gienow1998, author = {Gienow, Wilfried}, title = {Filmsequenzen und Lernertexte: Fremdsprachenerwerb als interaktiv-konstruktiver Prozess}, year = {1998}, language = {de} } @article{Gienow1996, author = {Gienow, Wilfried}, title = {Lernen : Medien, Prozesse, Produkte}, year = {1996}, language = {de} } @article{Gienow1995, author = {Gienow, Wilfried}, title = {Vielfalt und Differenziertheit im Fremdsprachenunterricht mit Texten und Medien sichern : warum, was, wie?}, year = {1995}, language = {de} } @article{Gienow1997, author = {Gienow, Wilfried}, title = {Visualit{\"a}t im fremdsprachlichen Schreibprozeß : Begr{\"u}ndungen und Beispiele aus dem Englischunterricht}, year = {1997}, language = {de} } @article{Gienow1997, author = {Gienow, Wilfried}, title = {Aspekte prozeßorientierten Umgangs mit Medien beim Fremdsprachenerwerb}, year = {1997}, language = {de} } @article{Gienow1993, author = {Gienow, Wilfried}, title = {Integrating change : perspectives in english language teaching}, year = {1993}, language = {en} } @article{Gienow1993, author = {Gienow, Wilfried}, title = {Differenzierte Informationspr{\"a}sentation und -verarbeitung : eine Begr{\"u}ndung prozeßorientierter Arbeit mit Medien im Fremdsprachenunterricht}, year = {1993}, language = {de} } @article{Gienow1992, author = {Gienow, Wilfried}, title = {2nd English Studies Conference at the Freie Universit{\"a}t Berlin}, year = {1992}, language = {en} } @article{Gienow1995, author = {Gienow, Wilfried}, title = {Thesen zur Weiterentwicklung einer neusprachlichen Mediendidaktik}, year = {1995}, language = {de} } @article{Gienow1995, author = {Gienow, Wilfried}, title = {Textvielfalt im Englischunterricht - eine Voraussetzung f{\"u}r bildenden Fremdsprachenerwerb?}, year = {1995}, language = {de} } @article{Gienow1994, author = {Gienow, Wilfried}, title = {Gegen mediale Abstinenz und Maßlosigkeit f{\"u}r eine prozeßorientierte Medienpraxis im Fremdsprachenunterricht}, year = {1994}, language = {de} } @article{Gienow1994, author = {Gienow, Wilfried}, title = {Verst{\"a}ndiger werden im Englischunterricht? : Beispiele prozeßorientierten Medieneinsatzes, m{\"o}gliche Wirkungen und Begr{\"u}ndungen}, year = {1994}, language = {de} } @article{Gienow1991, author = {Gienow, Wilfried}, title = {Zum Verst{\"a}ndnis von Veranschaulichung beim Fremdsprachenerwerb}, isbn = {3-923549-43-1}, year = {1991}, language = {de} } @article{Gienow1999, author = {Gienow, Wilfried}, title = {Mediale Textvielfalt und Lerneraktivit{\"a}t : Sprach- und Sinnbildung in Grundlagen und Beispielen des Englischunterrichts}, year = {1999}, language = {de} } @article{GiengRailaRosales2005, author = {Gieng, S. H. and Raila, Jens and Rosales, F. J.}, title = {Accumulation of retinol in the liver after prolonged hyporetinolemia in the vitamin A-sufficient rat}, issn = {0022-2275}, year = {2005}, abstract = {We assessed the effects of prolonged reduction of plasma retinol concentrations (hyporetinolemia) on the distribution of tissue vitamin A (VA) and of its active compounds using a model of continuous recombinant human interleukin-6 (rhIL-6) infusion via osmotic minipumps in VA-sufficient male rats. Plasma retinol and retinol-binding protein (RBP) concentrations remained decreased and lower in rhIL-6- treated rats compared with controls from 7.5 h throughout 7 days of infusion (P < 0.001). This reduction was accompanied by a 68\% increase in hepatic retinol concentration by 7 days (P < 0.05). Hepatic and renal retinyl palmitate and retinoic acid concentrations did not change, and renal megalin content remained unchanged; hepatic RBP concentrations were 41\% lower in rhIL-6-treated rats compared with controls (P < 0.05). These results indicate that instead of being lost, retinol accumulated in the liver during inflammation and that hyporetinolemia was attributable to a decrease in the availability of hepatic RBP. A plausible consequence of the effect of rhIL-6-induced hyporetinolemia is that by 7 days tissues that are dependent on plasma retinol may become deprived of VA. These results have important implications in understanding the mechanism by which measles infection induces hyporetinolemia and VA deficiency of extrahepatic tissues}, language = {en} } @article{Giel2015, author = {Giel, Barbara}, title = {Sprachtherapeutische F{\"o}rderung bei Kindern mit Down-Syndrom (SF-KiDS)}, series = {Spektrum Patholinguistik (Band 8) - Schwerpunktthema: Besonders behandeln? : Sprachtherapie im Rahmen prim{\"a}rer St{\"o}rungsbilder}, journal = {Spektrum Patholinguistik (Band 8) - Schwerpunktthema: Besonders behandeln? : Sprachtherapie im Rahmen prim{\"a}rer St{\"o}rungsbilder}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-79731}, pages = {41 -- 56}, year = {2015}, language = {de} } @article{GiegSchianchiDietrichetal.2022, author = {Gieg, Henrique and Schianchi, Federico and Dietrich, Tim and Ujevic, Maximiliano}, title = {Incorporating a Radiative Hydrodynamics Scheme in the Numerical-Relativity Code BAM}, series = {Universe : open access journal}, volume = {8}, journal = {Universe : open access journal}, number = {7}, publisher = {MDPI}, address = {Basel}, issn = {2218-1997}, doi = {10.3390/universe8070370}, pages = {25}, year = {2022}, abstract = {To study binary neutron star systems and to interpret observational data such as gravitational-wave and kilonova signals, one needs an accurate description of the processes that take place during the final stages of the coalescence, for example, through numerical-relativity simulations. In this work, we present an updated version of the numerical-relativity code BAM in order to incorporate nuclear-theory-based equations of state and a simple description of neutrino interactions through a neutrino leakage scheme. Different test simulations, for stars undergoing a neutrino-induced gravitational collapse and for binary neutron stars systems, validate our new implementation. For the binary neutron stars systems, we show that we can evolve stably and accurately distinct microphysical models employing the different equations of state: SFHo, DD2, and the hyperonic BHB Lambda phi. Overall, our test simulations have good agreement with those reported in the literature.}, language = {en} } @article{GieblerSchulzReicheetal.1999, author = {Giebler, Rainer and Schulz, Burkhard and Reiche, J{\"u}rgen and Brehmer, Ludwig and W{\"u}hn, Mario and W{\"o}ll, Christoph and Smith, Andrew Phillip and Urquhart, Steven G. and Ade, Harald W. and Unger, Wolfgang E. S.}, title = {Near-edge x-ray absorption fine structure spectroscopy on ordered films of an amphiphilic derivate of 2,5- Diphenyl-1,3,4-oxadiazole}, year = {1999}, abstract = {The surfaces of ordered films formed from an amphiphilic derivative of 2,5-diphenyl-1,3,4-oxadiazole by the Langmuir-Blodgett (LB) technique and organic molecular beam deposition (OMBD) were investigated by the use of near-edge X-ray absorption fine structure (NEXAFS) spectroscopy. For the assignment of the spectral features of the C, N, and O K- edge absorption spectra, fingerprint spectra of poly(p-phenylene terephthalamide)(Kevlar), poly(ethylene terephthalate), poly(p-phenylene-1,3,4-oxadiazole), and 2,5-di- (pentadecyl)-1,3,4-oxadiazole, which contain related chemical moieties, were recorded. Ab initio molecular orbital calculations, performed with explicit treatment of the core hole, are used to support the spectral interpretations. Angle-resolved NEXAFS spectroscopy at the C, N, and O K-edges suggests a preferentially upright orientation of the oxadiazole derivative in the outermost layer of the films. X-ray specular reflectivity data and molecular modeling results suggest a similar interpretation.}, language = {en} } @misc{GieblerRuthTanneberg2018, author = {Giebler, Heiko and Ruth, Saskia P. and Tanneberg, Dag}, title = {Why choice matters}, series = {Politics and Governance}, volume = {6}, journal = {Politics and Governance}, number = {1}, publisher = {Cogitatio Press}, address = {Lisbon}, issn = {2183-2463}, doi = {10.17645/pag.v6i1.1428}, pages = {1 -- 10}, year = {2018}, abstract = {Measures of democracy are in high demand. Scientific and public audiences use them to describe political realities and to substantiate causal claims about those realities. This introduction to the thematic issue reviews the history of democracy measurement since the 1950s. It identifies four development phases of the field, which are characterized by three recurrent topics of debate: (1) what is democracy, (2) what is a good measure of democracy, and (3) do our measurements of democracy register real-world developments? As the answers to those questions have been changing over time, the field of democracy measurement has adapted and reached higher levels of theoretical and methodological sophistication. In effect, the challenges facing contemporary social scientists are not only limited to the challenge of constructing a sound index of democracy. Today, they also need a profound understanding of the differences between various measures of democracy and their implications for empirical applications. The introduction outlines how the contributions to this thematic issue help scholars cope with the recurrent issues of conceptualization, measurement, and application, and concludes by identifying avenues for future research.}, language = {en} } @misc{GieblerRuthTanneberg2018, author = {Giebler, Heiko and Ruth, Saskia P. and Tanneberg, Dag}, title = {Why choice matters}, series = {Postprints der Universit{\"a}t Potsdam Wirtschafts- und Sozialwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam Wirtschafts- und Sozialwissenschaftliche Reihe}, number = {104}, issn = {1867-5808}, doi = {10.25932/publishup-42789}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-427891}, pages = {10}, year = {2018}, abstract = {Measures of democracy are in high demand. Scientific and public audiences use them to describe political realities and to substantiate causal claims about those realities. This introduction to the thematic issue reviews the history of democracy measurement since the 1950s. It identifies four development phases of the field, which are characterized by three recurrent topics of debate: (1) what is democracy, (2) what is a good measure of democracy, and (3) do our measurements of democracy register real-world developments? As the answers to those questions have been changing over time, the field of democracy measurement has adapted and reached higher levels of theoretical and methodological sophistication. In effect, the challenges facing contemporary social scientists are not only limited to the challenge of constructing a sound index of democracy. Today, they also need a profound understanding of the differences between various measures of democracy and their implications for empirical applications. The introduction outlines how the contributions to this thematic issue help scholars cope with the recurrent issues of conceptualization, measurement, and application, and concludes by identifying avenues for future research.}, language = {en} } @article{GiebingObermannFuerstetal.1997, author = {Giebing, Thomas and Obermann, Wolfgang and F{\"u}rst, Dieter Oswald and D'Haese, Jochen}, title = {C-terminally deleted fragments of 40-kDa earthworm actin modulator still shows gelsolin activities}, year = {1997}, language = {en} } @article{GiebingToelleJuergensenetal.2005, author = {Giebing, G{\"u}nter and T{\"o}lle, Markus and J{\"u}rgensen, Jana and Eichhorst, Jenny and Furkert, Jens and Beyermann, Michael and Neusch{\"a}fer-Rube, Frank and Rosenthal, Walter and Zidek, Walter and van der Giet, Markus and Oksche, Alexander}, title = {Arrestin-independent internalization and recycling of the urotensin receptor contribute to long-lasting urotensin II - Mediated vasoconstriction}, issn = {0009-7330}, year = {2005}, abstract = {Urotensin II (UII), which acts on the G protein-coupled urotensin ( UT) receptor, elicits long-lasting vasoconstriction. The role of UT receptor internalization and intracellular trafficking in vasoconstriction has yet not been analyzed. Therefore, UII-mediated contractile responses of aortic ring preparations in wire myography and rat UT (rUT) receptor internalization and intracellular trafficking in binding and imaging analyses were compared. UII elicited a concentration-dependent vasoconstriction of rat aorta (-log EC50, mol/L:9.0 +/- 0.1). A second application of UII after 30 minutes elicited a reduced contraction (36 +/- 4\% of the initial response), but when applied after 60 minutes elicited a full contraction. In internalization experiments with radioactive labeled VII (I-125-UII), approximate to 70\% of rUT receptors expressed on the cell surface of human embryonic kidney 293 cells were sequestered within 30 minutes (half life [t(h)]: 5.6 +/- 0.2 minutes), but recycled quantitatively within 60 minutes (t(h) 31.9 +/- 2.6 minutes). UII- bound rUT receptors were sorted to early and recycling endosomes, as evidenced by colocalization of rUT receptors with the early endosomal antigen and the transferrin receptor. Real-time imaging with a newly developed fluorescent UII (Cy3- UII) revealed that rUT receptors recruited arrestin3 green fluorescent protein to the plasma membrane. Arrestin3 was not required for the endocytosis of the rUT receptor, however, as internalization of Cy3-UII was not altered in mouse embryonic fibroblasts lacking endogenous arrestin2/arrestin3 expression. The data demonstrate that the rUT receptor internalizes arrestin independently and recycles quantitatively. The continuous externalization of rUT receptors provides the basis for repetitive and lasting UII-mediated vasoconstriction}, language = {en} } @phdthesis{Giebel1993, author = {Giebel, Birgit}, title = {Diagnostik der Rhythmusf{\"a}higkeit : Ergebnisse einer Studie an 13-j{\"a}hrigen Kindern}, year = {1993}, language = {de} } @article{GidionGerhard2018, author = {Gidion, Gunnar and Gerhard, Reimund}, title = {The Bow on a String}, series = {Acta Acustica united with Acustica}, volume = {104}, journal = {Acta Acustica united with Acustica}, number = {2}, publisher = {Hirzel Verlag}, address = {Stuttgart}, issn = {1610-1928}, doi = {10.3813/AAA.919174}, pages = {315 -- 322}, year = {2018}, abstract = {The interaction between a bowed string instrument and its player is conveyed by the bow, the vibrational properties of which can be measured either separately on the bow or during the bowing procedure. Here, two piezoelectric film sensors, made of a ferroelectret material, are installed on a violin bow, one sensor at the tip and one at the frog. With these sensors, a violin is played under normal conditions, and the signals are analysed. The features in the resulting spectrograms are identified as string harmonics and longitudinal bow-hair resonances. The bow-hair sections on both sides of the bow-string contact exhibit separate resonances which are observed as absorption dips in the spectra. Owing to the sensor positions at the bow-hair terminations, it can be inferred that the two bow-hair sections act as mutual vibration absorbers. From a regression of the observed resonances, the longitudinal bow-hair velocity can be obtained. With additional film sensors under the violin bridge, body vibrations were also detected providing further details of the coupling mechanisms.}, language = {en} } @phdthesis{Gidion2018, author = {Gidion, Gunnar}, title = {Akustische Resonatoren zur Analyse und Kontrolle von schwingungsf{\"a}higen Systemen am Beispiel von Streichinstrumenten und Dielektrischen Elastomeraktoren}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-411772}, school = {Universit{\"a}t Potsdam}, pages = {190}, year = {2018}, abstract = {Die Klangeigenschaften von Musikinstrumenten werden durch das Zusammenwirken der auf ihnen anregbaren akustischen Schwingungsmoden bestimmt, welche sich wiederum aus der geometrischen Struktur des Resonators in Kombination mit den verwendeten Materialien ergeben. In dieser Arbeit wurde das Schwingungsverhalten von Streichinstrumenten durch den Einsatz minimal-invasiver piezoelektrischer Polymerfilmsensoren untersucht. Die studierten Kopplungsph{\"a}nomene umfassen den sogenannten Wolfton und Schwingungstilger, die zu dessen Abschw{\"a}chung verwendet werden, sowie die gegenseitige Beeinflussung von Bogen und Instrument beim Spielvorgang. An Dielektrischen Elastomeraktormembranen wurde dagegen der Einfluss der elastischen Eigenschaften des Membranmaterials auf das akustische und elektromechanische Schwingungsverhalten gezeigt. Die Dissertation gliedert sich in drei Teile, deren wesentliche Ergebnisse im Folgenden zusammengefasst werden. In Teil I wurde die Funktionsweise eines abstimmbaren Schwingungstilgers zur D{\"a}mpfung von Wolft{\"o}nen auf Streichinstrumenten untersucht. Durch Abstimmung der Resonanzfrequenz des Schwingungstilgers auf die Wolftonfrequenz kann ein Teil der Saitenschwingungen absorbiert werden, so dass die zu starke Anregung der Korpusresonanz vermieden wird, die den Wolfton verursacht. Der Schwingungstilger besteht aus einem „Wolft{\"o}ter", einem Massest{\"u}ck, welches auf der Nachl{\"a}nge der betroffenen Saite (zwischen Steg und Saitenhalter) installiert wird. Hier wurde gezeigt, wie die Resonanzen dieses Schwingungstilgers von der Masse des Wolft{\"o}ters und von dessen Position auf der Nachl{\"a}nge abh{\"a}ngen. Aber auch die Geometrie des Wolft{\"o}ters stellte sich als ausschlaggebend heraus, insbesondere bei einem nicht-rotationssymmetrischen Wolft{\"o}ter: In diesem Fall entsteht - basierend auf den zu erwartenden nicht-harmonischen Moden einer massebelasteten Saite - eine zus{\"a}tzliche Mode, die von der Polarisationsrichtung der Saitenschwingung abh{\"a}ngt. Teil II der Dissertation befasst sich mit Elastomermembranen, die als Basis von Dielektrischen Elastomeraktoren dienen, und die wegen der Membranspannung auch akustische Resonanzen aufweisen. Die Ansprache von Elastomeraktoren h{\"a}ngt unter anderem von der Geschwindigkeit der elektrischen Anregung ab. Die damit zusammenh{\"a}ngenden viskoelastischen Eigenschaften der hier verwendeten Elastomere, Silikon und Acrylat, wurden einerseits in einer frequenzabh{\"a}ngigen dynamisch-mechanischen Analyse des Elastomers erfasst, andererseits auch optisch an vollst{\"a}ndigen Aktoren selbst gemessen. Die h{\"o}here Viskosit{\"a}t des Acrylats, das bei tieferen Frequenzen h{\"o}here Aktuationsdehnungen als das Silikon zeigt, f{\"u}hrt zu einer Verminderung der Dehnungen bei h{\"o}heren Frequenzen, so dass {\"u}ber etwa 40 Hertz mit Silikon gr{\"o}ßere Aktuationsdehnungen erreicht werden. Mit den untersuchten Aktoren konnte die Gitterkonstante weicher optischer Beugungsgitter kontrolliert werden, die als zus{\"a}tzlicher Film auf der Membran installiert wurden. {\"U}ber eine Messung der akustischen Resonanzfrequenz von Elastomermebranen aus Acrylat in 1Abh{\"a}ngigkeit von ihrer Vorstreckung konnte in Verbindung mit einer Modellierung des hyperelastischen Verhaltens des Elastomers (Ogden-Modell) der Schermodul bestimmt werden. Schließlich wird in Teil III die Untersuchung von Geigen und ihrer Streichanregung mit Hilfe minimal-invasiver piezoelektrischer Polymerfilme geschildert. Es konnten am Bogen und am Steg von Geigen - unter den beiden F{\"u}ßen des Stegs - jeweils zwei Filmsensoren installiert werden. Mit den beiden Sensoren am Steg wurden Frequenzg{\"a}nge von Geigen gemessen, welche eine Bestimmung der frequenzabh{\"a}ngigen Stegbewegung erlaubten. Diese Methode erm{\"o}glicht damit auch eine umfassende Charakterisierung der Signaturmoden in Bezug auf die Stegdynamik. Die Ergebnisse der komplement{\"a}ren Methoden von Impulsanregung und nat{\"u}rlichem Spielen der Geigen konnten dank der Sensoren verglichen werden. F{\"u}r die Nutzung der Sensoren am Bogen - insbesondere f{\"u}r eine Messung des Bogendrucks - wurde eine Kalibrierung des Bogen-Sensor-Systems mit Hilfe einer Materialpr{\"u}fmaschine durchgef{\"u}hrt. Bei einer Messung w{\"a}hrend des nat{\"u}rlichen Spielens wurde mit den Sensoren am Bogen einerseits die {\"U}bertragung der Saitenschwingung auf den Bogen festgestellt. Dabei konnten außerdem longitudinale Bogenhaarresonanzen identifiziert werden, die von der Position der Saite auf dem Bogen abh{\"a}ngen. Aus der Analyse dieses Ph{\"a}nomens konnte die longitudinale Wellengeschwindigkeit der Bogenhaare bestimmt werden, die eine wichtige Gr{\"o}ße f{\"u}r die Kopplung zwischen Saite und Bogen ist. Mit Hilfe des Systems aus Sensoren an Bogen und Steg werden auf Grundlage der vorliegenden Arbeit Studien an Streichinstrumenten vorgeschlagen, in denen die Bespielbarkeit der Instrumente zu den jeweils angeregten Steg- und Bogenschwingungen in Beziehung gesetzt werden kann. Damit k{\"o}nnte nicht zuletzt auch die bisher nicht vollst{\"a}ndig gekl{\"a}rte Rolle des Bogens f{\"u}r Klang und Bespielbarkeit besser beurteilt werden}, language = {de} } @article{GibsonSotiropoulouTobinetal.2019, author = {Gibson, Mark and Sotiropoulou, Stavroula and Tobin, Stephen and Gafos, Adamantios I.}, title = {Temporal Aspects of Word Initial Single Consonants and Consonants in Clusters in Spanish}, series = {Phonetic}, volume = {76}, journal = {Phonetic}, number = {6}, publisher = {Karger}, address = {Basel}, issn = {0031-8388}, doi = {10.1159/000501508}, pages = {448 -- 478}, year = {2019}, abstract = {We examined gestural coordination in C1C2 (C1 stop, C2 lateral or tap) word initial clusters using articulatory (electromagnetic articulometry) and acoustic data from six speakers of Standard Peninsular Spanish. We report on patterns of voice onset time (VOT), gestural plateau duration of C1, C2, and their overlap. For VOT, as expected, place of articulation is a major factor, with velars exhibiting longer VOTs than labials. Regarding C1 plateau duration, voice and place effects were found such that voiced consonants are significantly shorter than voiceless consonants, and velars show longer duration than labials. For C2 plateau duration, lateral duration was found to vary as a function of onset complexity (C vs. CC). As for overlap, unlike in French, where articulatory data for clusters have also been examined, clusters where both C1 and C2 are voiced show more overlap than where voicing differs. Further, overlap was affected by the C2 such that clusters where C2 is a tap show less overlap than clusters where C2 is a lateral. We discuss these results in the context of work aiming to uncover phonetic (e.g., articulatory or perceptual) and phonological forces (e.g., syllabic organization) on timing.}, language = {en} } @phdthesis{Gibert2021, author = {Gibert, Arthur}, title = {Influence of Amyloid Aggregates on the Trafficking and Signaling of GPCRs}, doi = {10.25932/publishup-50665}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-506659}, school = {Universit{\"a}t Potsdam}, pages = {100}, year = {2021}, abstract = {The prevalence of diseases associated with misfolded proteins increases with age. When cellular defense mechanisms become limited, misfolded proteins form aggregates and may also develop more stable cross-β structures ultimately forming amyloid aggregates. Amyloid aggregates are associated with neurodegenerative diseases such as Alzheimer's disease and Huntington's disease. The formation of amyloid deposits, their toxicity and cellular defense mechanisms have been intensively studied. However, surprisingly little is known about the effects of protein aggregates on cellular signal transduction. It is also not understood whether the presence of aggregation-prone, but still soluble proteins affect signal transduction. In this study, the still soluble aggregation-prone HttExon1Q74 and its amyloid aggregates were used to analyze the effect of amyloid aggregates on internalization and receptor activation of G protein-coupled receptors (GPCRs), the largest protein family of mammalian cell surface receptors involved in signal transduction. The aggregated HttExon1Q74, but not its soluble form, could inhibit ligand-induced clathrin-mediated endocytosis (CME) of various GPCRs. Most likely this inhibitory effect is based on a terminal sequestration of the HSC70 chaperone to the aggregates which is necessary for CME. Using the vasopressinV1a receptor (V1aR) and the corticotropin-releasing factor receptor 1 (CRF1R) as a model, it could be shown that the presence of HttExon1Q74 aggregates and the inhibition of ligand-induced CME leads to an accumulation of desensitized receptors at the plasma membrane. In turn, this disrupts Gq-mediated Ca2+ signaling and Gs-mediated cAMP signaling of the V1aR and the CRF1R respectively. In contrast to HttExon1Q74 amyloid aggregates, soluble HttExon1Q74 as well as amorphous aggregates did not inhibit GPCR internalization and signaling demonstrating that cellular signal transduction mechanisms are specifically impaired in response to the formation of amyloid aggregates. In addition, preliminary experiments could show that HttExon1Q74 aggregates provoke an increase in membrane expression of a protein from a structurally and functionally unrelated membrane protein family, namely the serotonin transporter SERT. As SERT is the main pharmacological target to treat depression this could shed light on this commonly occurring comorbidity in neurodegenerative diseases, in particular in early disease states.}, language = {en} } @article{GibbsReevesSunnaetal.2004, author = {Gibbs, Moreland D. and Reeves, Rosalind A. and Sunna, Anwar and Bergquist, Peter L.}, title = {A yeast intron as a translational terminator in a plasmid shuttle vector}, issn = {1567-1356}, year = {2004}, abstract = {Plasmid shuttle vectors that contain both prokaryotic (Escherichia coli) and eukaryotic origins of replication are routinely used in molecular biology since E coli is generally the organism of choice for manipulation of recombinant DNA. Initial transformation of the shuttle vector into E coli allows production of microgram quantities of DNA suitable for transformation of low-transformationefficiency hosts. A shuttle/expression vector for the yeast Kluyveromyces lactis, pCWK1, allows recombinant protein fused to the killer toxin signal sequence to be secreted to the medium. The heterologous genes are transcribed under the control of the K lactis LAC4 promoter, which is tightly regulated in K lactis. However, in E coli the LAC4 promoter functions constitutively, and as a result, uncontrolled transcription and translation of genes that are toxic in E coli can result in cell death, and subsequent failure to recover intact E. coli transformants. We have constructed and tested a modified shuttle vector that contains a K lactis ribosomal intron that acts as a translational terminator in E coli, preventing or reducing the expression of recombinant proteins and avoiding toxicity. When transcribed in K lactis, the intron is spliced from the mRNA allowing the translation of intact full- length, active recombinant gene product. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved}, language = {en} } @misc{GibbonSelting1983, author = {Gibbon, Dafydd and Selting, Margret}, title = {Intonation und die Strukturierung eines Diskurses}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-41912}, year = {1983}, abstract = {Inhalt: 1. {\"U}berblick 2. Beschreibungskategorien f{\"u}r Intonation 3. Transkriptionskonventionen 4. Intonationsverl{\"a}ufe 5. Kontextbeschreibung 6. Semantische Diskursentwicklung 7. Zur Wechselwirkung von Intonation und Diskursverlauf}, language = {de} } @unpublished{GibaliShoikhetTarkhanov2015, author = {Gibali, Aviv and Shoikhet, David and Tarkhanov, Nikolai Nikolaevich}, title = {On the convergence of continuous Newton method}, volume = {4}, number = {10}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {2193-6943}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-81537}, pages = {15}, year = {2015}, abstract = {In this paper we study the convergence of continuous Newton method for solving nonlinear equations with holomorphic mappings in complex Banach spaces. Our contribution is based on a recent progress in the geometric theory of spirallike functions. We prove convergence theorems and illustrate them by numerical simulations.}, language = {en} } @article{GiarollaVeigaNobreetal.2020, author = {Giarolla, Emanuel and Veiga, Sandro F. and Nobre, Paulo and Silva, Manoel B. and Capistrano, Vinicius B. and Callegare, Andyara O.}, title = {Sea surface height trends in the southern hemisphere oceans simulated by the Brazilian Earth System Model under RCP4.5 and RCP8.5 scenarios}, series = {Journal of southern hemisphere earth systems science}, volume = {70}, journal = {Journal of southern hemisphere earth systems science}, number = {1}, publisher = {CSIRO}, address = {Clayton}, issn = {2206-5865}, doi = {10.1071/ES19042}, pages = {280 -- 289}, year = {2020}, abstract = {The Brazilian Earth System Model (BESM-OA2.5), while simulating the historical period proposed by the fifth phase of the Coupled Model Intercomparison Project (CMIP5), detects an increasing trend in the sea surface height (SSH) on the southern hemisphere oceans relative to that of the pre-industrial era. The increasing trend is accentuated in the CMIP5 RCP4.5 and RCP8.5 future scenarios with higher concentrations of greenhouse gases in the atmosphere. This study sheds light on the sources of such trends in these regions. The results suggest an association with the thermal expansion of the oceans in the upper 700 m due to a gradual warming inflicted by those future scenarios. BESM-OA2.5 presents a surface height increase of 0.11 m in the historical period of 1850-2005. Concerning future projections, BESM-OA2.5 projects SSH increases of 0.14 and 0.23 m (relative to the historical 2005 value) for RCP4.5 and RCP8.5, respectively, by the end of 2100. These increases are predominantly in a band of latitude within 35-60 degrees S in the Atlantic and Indian oceans. The reproducibility of the trend signal detected in the BESM-OA2.5 simulations is confirmed by the results of three other CMIP5 models.}, language = {en} } @article{Giardina1998, author = {Giardina, Roberto}, title = {Niedergang eines Abenteuers : beim Giro d"Italia z{\"a}hlt nicht allein die Zeit}, year = {1998}, language = {de} } @article{GianturcoKumarVetteretal.1997, author = {Gianturco, Franco A. and Kumar, Sanjay and Vetter, Reinhard and Ritschel, Thomas and Z{\"u}licke, Lutz}, title = {Interaction anisotropy and vibrational excitation in proton scattering from N2(1sigma g+)}, year = {1997}, language = {en} } @article{GiannitsisRothLeithaeuseretal.2009, author = {Giannitsis, Evangelos and Roth, Heinz J{\"u}rgen and Leithaeuser, Renate M. and Scherhag, J{\"u}rgen and Beneke, Ralt and Katus, Hugo A.}, title = {New highly sensitivity assay used to measure cardiac troponin T concentration changes during a continuous 216- km marathon}, issn = {0009-9147}, doi = {10.1373/clinchem.2008.116566}, year = {2009}, language = {en} } @article{GianniotisSchnoerrMolkenthinetal.2016, author = {Gianniotis, Nikolaos and Schnoerr, Christoph and Molkenthin, Christian and Bora, Sanjay Singh}, title = {Approximate variational inference based on a finite sample of Gaussian latent variables}, series = {Pattern Analysis \& Applications}, volume = {19}, journal = {Pattern Analysis \& Applications}, publisher = {Springer}, address = {New York}, issn = {1433-7541}, doi = {10.1007/s10044-015-0496-9}, pages = {475 -- 485}, year = {2016}, abstract = {Variational methods are employed in situations where exact Bayesian inference becomes intractable due to the difficulty in performing certain integrals. Typically, variational methods postulate a tractable posterior and formulate a lower bound on the desired integral to be approximated, e.g. marginal likelihood. The lower bound is then optimised with respect to its free parameters, the so-called variational parameters. However, this is not always possible as for certain integrals it is very challenging (or tedious) to come up with a suitable lower bound. Here, we propose a simple scheme that overcomes some of the awkward cases where the usual variational treatment becomes difficult. The scheme relies on a rewriting of the lower bound on the model log-likelihood. We demonstrate the proposed scheme on a number of synthetic and real examples, as well as on a real geophysical model for which the standard variational approaches are inapplicable.}, language = {en} } @article{GianniotisKuehnScherbaum2014, author = {Gianniotis, Nikolaos and Kuehn, Nicolas and Scherbaum, Frank}, title = {Manifold aligned ground motion prediction equations for regional datasets}, series = {Computers \& geosciences : an international journal devoted to the publication of papers on all aspects of geocomputation and to the distribution of computer programs and test data sets ; an official journal of the International Association for Mathematical Geology}, volume = {69}, journal = {Computers \& geosciences : an international journal devoted to the publication of papers on all aspects of geocomputation and to the distribution of computer programs and test data sets ; an official journal of the International Association for Mathematical Geology}, publisher = {Elsevier}, address = {Oxford}, issn = {0098-3004}, doi = {10.1016/j.cageo.2014.04.014}, pages = {72 -- 77}, year = {2014}, abstract = {Inferring a ground-motion prediction equation (GMPE) for a region in which only a small number of seismic events has been observed is a challenging task. A response to this data scarcity is to utilise data from other regions in the hope that there exist common patterns in the generation of ground motion that can contribute to the development of a GMPE for the region in question. This is not an unreasonable course of action since we expect regional GMPEs to be related to each other. In this work we model this relatedness by assuming that the regional GMPEs occupy a common low-dimensional manifold in the space of all possible GMPEs. As a consequence, the GMPEs are fitted in a joint manner and not independent of each other, borrowing predictive strength from each other's regional datasets. Experimentation on a real dataset shows that the manifold assumption displays better predictive performance over fitting regional GMPEs independent of each other. (C) 2014 Elsevier Ltd. All rights reserved.}, language = {en} } @article{GianniniRichterServettoetal.2018, author = {Giannini, Paola and Richter, Tim and Servetto, Marco and Zucca, Elena}, title = {Tracing sharing in an imperative pure calculus}, series = {Science of computer programming}, volume = {172}, journal = {Science of computer programming}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0167-6423}, doi = {10.1016/j.scico.2018.11.007}, pages = {180 -- 202}, year = {2018}, abstract = {We introduce a type and effect system, for an imperative object calculus, which infers sharing possibly introduced by the evaluation of an expression, represented as an equivalence relation among its free variables. This direct representation of sharing effects at the syntactic level allows us to express in a natural way, and to generalize, widely-used notions in literature, notably uniqueness and borrowing. Moreover, the calculus is pure in the sense that reduction is defined on language terms only, since they directly encode store. The advantage of this non-standard execution model with respect to a behaviorally equivalent standard model using a global auxiliary structure is that reachability relations among references are partly encoded by scoping. (C) 2018 Elsevier B.V. All rights reserved.}, language = {en} } @article{GiannettiUmanskySened2022, author = {Giannetti, Daniela and Umansky, Karen and Sened, Itai}, title = {The entry of the M5S and the reshaping of party politics in Italy (2008-2018)}, series = {Government \& opposition}, volume = {59}, journal = {Government \& opposition}, number = {2}, publisher = {Cambridge University Press}, address = {Cambridge}, issn = {0017-257X}, doi = {10.1017/gov.2022.38}, pages = {464 -- 481}, year = {2022}, abstract = {This article examines how challenger parties enter the political arena and the effect of this entry by looking at the Italian 5 Star Movement (Movimento 5 Stelle - M5S). We explain the M5S's entry strategy in 2013 using the spatial approach to party competition and employing expert survey data collected for each national election between 2008 and 2018. These data allow us to analyse the changing spatial configuration of Italian politics due to the increasing salience of pro/anti-EU and pro/anti-immigration dimensions. We then apply the theoretical notion of the uncovered set (UCS) to trace how the M5S's entry reshaped the overall space of party competition, causing a realignment of existing parties. This work contributes to the ongoing debate on the electoral success of challenger parties and the emerging cleavages and polarization of party systems in Western European countries.}, language = {en} } @article{GiannatelliTomasini2023, author = {Giannatelli, Ada and Tomasini, Alessandra}, title = {Descriptors and EU Standards to support the recognition of MOOCs}, series = {EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?}, journal = {EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?}, editor = {Meinel, Christoph and Schweiger, Stefanie and Staubitz, Thomas and Conrad, Robert and Alario Hoyos, Carlos and Ebner, Martin and Sancassani, Susanna and Żur, Agnieszka and Friedl, Christian and Halawa, Sherif and Gamage, Dilrukshi and Scott, Jeffrey and Kristine Jonson Carlon, May and Deville, Yves and Gaebel, Michael and Delgado Kloos, Carlos and von Schmieden, Karen}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, doi = {10.25932/publishup-62396}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-623967}, pages = {133 -- 146}, year = {2023}, abstract = {Digital technologies have enabled a variety of learning offers that opened new challenges in terms of recognition of formal, informal and non-formal learning, such as MOOCs. This paper focuses on how providing relevant data to describe a MOOC is conducive to increase the transparency of information and, ultimately, the flexibility of European higher education. The EU-funded project ECCOE took up these challenges and developed a solution by identifying the most relevant descriptors of a learning opportunity with a view to supporting a European system for micro-credentials. Descriptors indicate the specific properties of a learning opportunity according to European standards. They can provide a recognition framework also for small volumes of learning (micro-credentials) to support the integration of non-formal learning (MOOCs) into formal learning (e.g. institutional university courses) and to tackle skills shortage, upskilling and reskilling by acquiring relevant competencies. The focus on learning outcomes can facilitate the recognition of skills and competences of students and enhance both virtual and physical mobility and employability. This paper presents two contexts where ECCOE descriptors have been adopted: the Politecnico di Milano MOOC platform (Polimi Open Knowledge - POK), which is using these descriptors as the standard information to document the features of its learning opportunities, and the EU-funded Uforest project on urban forestry, which developed a blended training program for students of partner universities whose MOOCs used the ECCOE descriptors. Practice with ECCOE descriptors shows how they can be used not only to detail MOOC features, but also as a compass to design the learning offer. In addition, some rules of thumb can be derived and applied when using specific descriptors.}, language = {en} } @article{GiangrisostomiOvsyannikovSorgenfreietal.2018, author = {Giangrisostomi, Erika and Ovsyannikov, Ruslan and Sorgenfrei, Nomi and Zhang, Teng and Lindblad, Andreas and Sassa, Yasmine and Cappel, Ute B. and Leitner, Torsten and Mitzner, Rolf and Svensson, Svante and Martensson, Nils and F{\"o}hlisch, Alexander}, title = {Low Dose Photoelectron Spectroscopy at BESSY II}, series = {Journal of electron spectroscopy and related phenomena : the international journal on theoretical and experimental aspects of electron spectroscopy}, volume = {224}, journal = {Journal of electron spectroscopy and related phenomena : the international journal on theoretical and experimental aspects of electron spectroscopy}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0368-2048}, doi = {10.1016/j.elspec.2017.05.011}, pages = {68 -- 78}, year = {2018}, abstract = {The implementation of a high-transmission, angular-resolved time-of-Right electron spectrometer with a 1.25 MHz pulse selector at the PM4 soft X-ray dipole beamline of the synchrotron BESSY II creates unique capabilities to inquire electronic structure via photoelectron spectroscopy with a minimum of radiation dose. Solid-state samples can be prepared and characterized with standard UHV techniques and rapidly transferred from various preparation chambers to a 4-axis temperature-controlled measurement stage. A synchronized MHz laser system enables excited-state characterization and dynamical studies starting from the picosecond timescale. This article introduces the principal characteristics of the PM4 beamline and LowDosePES end-station. Recent results from graphene, an organic hole transport material for solar cells and the transition metal dichalcogenide MoS2 are presented to demonstrate the instrument performances.}, language = {en} } @inproceedings{GianelliRanziniMarzocchietal.2012, author = {Gianelli, Claudia and Ranzini, Mariagrazia and Marzocchi, Michele and Micheli, Leticia Rettore and Borghi, Anna M.}, title = {Influence of numerical magnitudes on the free choice of an object position}, series = {Cognitive processing : international quarterly of cognitive science}, volume = {13}, booktitle = {Cognitive processing : international quarterly of cognitive science}, publisher = {Springer}, address = {Heidelberg}, issn = {1612-4782}, pages = {S41 -- S41}, year = {2012}, language = {en} } @article{GianelliRanziniMarzocchietal.2012, author = {Gianelli, Claudia and Ranzini, Mariagrazia and Marzocchi, Michele and Micheli, Leticia Rettore and Borghi, Anna M.}, title = {Influence of numerical magnitudes on the free choice of an object position}, series = {Cognitive processing : international quarterly of cognitive science}, volume = {13}, journal = {Cognitive processing : international quarterly of cognitive science}, publisher = {Springer}, address = {Heidelberg}, issn = {1612-4782}, doi = {10.1007/s10339-012-0483-7}, pages = {S185 -- S188}, year = {2012}, abstract = {The link between numerical magnitude and mechanisms of spatial orienting has been underlined in an increasing number of studies. Similarly, the relationship between numerical magnitude and grasping actions has started to be investigated. The present study focuses on the influence of numerical magnitude processing in the free choice of the position of an object. Participants were presented with a digit (1-9 without 5) and were required to decide whether it was smaller or larger than 5. Then, they had to grasp a small cube and change its position before vocally responding "higher" or "lower". Results showed that in the initial phase of the grasp movement, the grip aperture was modulated by the numerical magnitude. Moreover, participants shifted the position of the cube more leftward with smaller digits compared with larger ones, and they tended to position the object closer to themselves with smaller digits compared with larger ones. These results extend the previous findings indicating that the processing of magnitude is tightly related to the mechanisms of spatial orienting that subserve action execution.}, language = {en} } @article{GianelliMarzocchiBorghi2017, author = {Gianelli, Claudia and Marzocchi, Michele and Borghi, Anna M.}, title = {Grasping the Agent's Perspective}, series = {Frontiers in psychology}, volume = {8}, journal = {Frontiers in psychology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2017.00042}, pages = {13}, year = {2017}, language = {en} }