@misc{Kraemer2009, author = {Kr{\"a}mer, Raimund}, title = {Mission Weltfrieden? : ein Gespr{\"a}ch mit Dr. Gernot Erler, Staatsminister im Ausw{\"a}rtigen Amt}, issn = {0944-8101}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32802}, year = {2009}, abstract = {In einem Interview pr{\"a}sentiert Dr. Gernot Erler (SPD, Staatsminister im Ausw{\"a}rtigen Amt)sein neuestes Buch „Mission Weltfrieden: Deutschlands neue Rolle in der Weltpolitik" und gibt damit Einblicke in die Außenpolitik der Großen Koalition und der unter Gerhard Schr{\"o}der.}, language = {de} } @misc{ImhofRudolphUnkrueer2009, author = {Imhof-Rudolph, Heike and Unkr{\"u}er, Angela}, title = {Von konzentrischen Kreisen und Geopolitik : ein Gespr{\"a}ch mit Eckart von Klaeden,außenpolitischer Sprecher der CDU/CSU Bundestagsfraktion}, issn = {0944-8101}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32797}, year = {2009}, abstract = {In einem Interview gibt Eckart von Klaeden (CDU/CSU) seine Einsch{\"a}tzung zur Außenpolitik in schwarz-rot. Er bescheinigt ihr Erfolge im Bereich der transatlantischen Beziehungen, der G-20 und bei der Europ{\"a}ischen Ratspr{\"a}sidentschaft.}, language = {de} } @misc{Sakson2009, author = {Sakson, Andrzej}, title = {Warschau zwischen Berlin und Moskau : eine polnische Sicht}, issn = {0944-8101}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32782}, year = {2009}, abstract = {Die polnische {\"O}ffentlichkeit reagiert auf Entwicklungen in den deutsch-russischen Beziehungen besonders sensibel. Der Autor analysiert die Ostpolitik unter Schr{\"o}der und Merkel und fordert eine st{\"a}rkere Ber{\"u}cksichtigung der polnischen Interessen in den deutsch-russischen Beziehungen.}, language = {de} } @misc{Beck2009, author = {Beck, Marieluise}, title = {Wechselseitige Neutralisierung}, issn = {0944-8101}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32774}, year = {2009}, abstract = {Zeichnet sich die Außenpolitik der Großen Koalition durch „mangelndes Profil" aus? Marieluise Beck belegt dies durch die deutsche Reaktion auf die Initiative f{\"u}r eine atomwaffenfreie Welt des US-Pr{\"a}sidenten. Auch bei den Debatten um Menschenrechte, den außenpolitischen Umgang mit China und Russland sowie die Verwendung von selektiven Sanktionen ist die Große Koalition den Anforderungen nicht gewachsen.}, language = {de} } @misc{Franzke2009, author = {Franzke, Jochen}, title = {Wertepolitik versus Realpolitik : die Russlandpolitik der Regierung Merkel/Steinmeier}, issn = {0944-8101}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32768}, year = {2009}, abstract = {Kooperative Beziehungen zu Russland sind angesichts der politisch-wirtschaftlichen Interessenlage, der geopolitischen Realit{\"a}ten im Osten Europas und des geschichtlichen Hintergrundes in der deutschen politischen Klasse Konsens. Mit dem Begriff der strategischen Partnerschaft werden die deutsch-russischen Beziehungen immer wieder charakterisiert, d. h. diese Kooperation soll weit {\"u}ber die normalen Interessen Deutschlands hinausgehen und eine globalpolitische Dimension erreichen.}, language = {de} } @misc{Goertemaker2009, author = {G{\"o}rtemaker, Manfred}, title = {Deutsche Außenpolitik vom Bismarck-Reich zur Berliner Republik}, issn = {0944-8101}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32752}, year = {2009}, abstract = {Die deutsche Außenpolitik hat seit dem 19. Jahrhundert bis zur Gegenwart viele Ver{\"a}nderungen erlebt. Lange stand Deutschland in einem angespannten Verh{\"a}ltnis zu den europ{\"a}ischen Ordnungen, doch nun ist es ein wichtiger Akteur der internationalen Gemeinschaft. Manfred G{\"o}rtemaker, Professor f{\"u}r Neuere Geschichte aus Potsdam, zeichnet die wichtigsten Stationen dieser Entwicklung in seinem Beitrag nach.}, language = {de} } @misc{Leibrecht2009, author = {Leibrecht, Harald}, title = {Die Außenpolitik der Großen Koalition : Bilanz aus liberaler Sicht}, issn = {0944-8101}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32747}, year = {2009}, abstract = {Deutschland ist wegen seiner verl{\"a}sslichen Außenpolitik ein weltweit angesehener Partner. Jedoch gelingt es der deutschen Außenpolitik momentan nicht, mit den Entwicklungen der globalisierten Welt Schritt zu halten. Bei wichtigen Themen hat die deutsche Regierung zu selten versucht, Stellung zu beziehen. Die F{\"a}higkeit zur friedlichen Konfliktl{\"o}sung muss Hauptanliegen unserer Außenpolitik sein. Als Grundlage daf{\"u}r muss ein st{\"a}ndiger Dialog auch mit den L{\"a}ndern, die unsere Werte nicht teilen, vorangetrieben werden.}, language = {de} } @misc{Voigt2009, author = {Voigt, Karsten D.}, title = {Auf der Suche nach der Außenpolitik der Großen Koalition}, issn = {0944-8101}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32738}, year = {2009}, abstract = {Der Koordinator f{\"u}r deutsch-amerikanische Zusammenarbeit im Ausw{\"a}rtigen Amt, Karsten Voigt, attestiert der Außenpolitik der Großen Koalition eine erfolgreiche, solide Arbeit. Diese setzt die international gesch{\"a}tzte deutsche Kontinuit{\"a}t und Verl{\"a}sslichkeit fort; auch in den zuletzt als schwierig empfundenen Beziehungen zu Russland und den USA.}, language = {de} } @misc{Pfetsch2009, author = {Pfetsch, Frank R.}, title = {Europ{\"a}ische Union als globale Macht : Pl{\"a}doyer f{\"u}r eine wertbestimmte interregionale Ordnungsmacht}, issn = {0944-8101}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32724}, year = {2009}, abstract = {Viele betrachten die EU als einen beh{\"a}bigen Koloss, den widerstreitende Interessen l{\"a}hmen. Der Autor weist die Kritiker jedoch in ihre Schranken. In seinem flammenden Pl{\"a}doyer f{\"u}r die EU veranschaulicht er ihre positive Wirkung nach außen. Dabei kommt er zu dem Schluss, dass die Aufgaben Europas als universale Wertegemeinschaft im Bereich des Krisenmanagements und der Friedensstiftung liegen.}, language = {de} } @misc{Schaefer2009, author = {Sch{\"a}fer, Paul}, title = {Bundesregierung mit Tunnelblick}, issn = {0944-8101}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32716}, year = {2009}, abstract = {Dass die Große Koalition die Kontinuit{\"a}t deutscher Außenpolitik fortsetzt, ist f{\"u}r den Autor, verteidigunspolitischer Sprecher von DIE LINKE, ein Zeichen der Stagnation, sogar des Versagens. Er wirft der Bundesregierung Einfallslosigkeit, mangelndes Engagement und kalte Interessenpolitik vor. Doch neben der umfassenden Kritik werden auch neue L{\"o}sungsans{\"a}tze vorgestellt, die sich auf Erwartungen an die neue US-Administration st{\"u}tzen.}, language = {de} } @misc{Zapf2009, author = {Zapf, Uta}, title = {Außenpolitischer Burgfrieden? : Kontinuit{\"a}t als Konsens}, issn = {0944-8101}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32702}, year = {2009}, abstract = {Wie stabil ist die Außenpolitik der Großen Koalition? Aufgrund ihrer Position als stellvertretende außenpolitische Sprecherin der SPD ist es der Autorin m{\"o}glich, neben den Gemeinsamkeiten auch die entscheidenden Unterschiede zu beleuchten. Vor dem Hintergrund mehrerer Beispiele, wie dem EU-Beitritt der T{\"u}rkei, stellt sie den Konsens zwischen CDU/ CSU und SPD als fragil heraus.}, language = {de} } @misc{OPUS4-3101, title = {Blattgold : Bist Du Deutschland?}, issn = {0944-8101}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32697}, year = {2009}, abstract = {"Deutschland ist schwer vermittelbar. Deutsche Kulturaußenpolitik tut, was sie kann. Das Goethe-Institut k{\"a}mpft so f{\"u}r die globale Friedensmacht Deutschland in aller Herren L{\"a}nder. Beim satzungsgem{\"a}ß gestellten Ziel der 'Vermittlung eines umfassenden Deutschlandbildes' f{\"a}llt ihm in seinem Internet-Glossar zu Deutschland dann aber f{\"u}r den Buchstaben C nur 'Cluster' ein. Vielleicht, weil es den Deutschen an 'Charisma' fehlt? [...]"}, language = {de} } @misc{Dittrich2009, author = {Dittrich, Denise}, title = {Thailand in der Dauerkrise}, issn = {0944-8101}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32686}, year = {2009}, abstract = {Mit dem erzwungenen Abbruch des ASEAN-Gipfels im April 2009 erreichte der politische Machtkampf in Thailand einen neuen H{\"o}hepunkt. Trotz des R{\"u}ckzuges der Aufst{\"a}ndischen ist kein Ende des Konflikts abzusehen. Die erhoffte politische Ruhe mit der Wahl Abhisit Vejjajivas zum neuen thail{\"a}ndischen Regierungschef hat sich in dem tief gespaltenen Land nicht eingestellt.}, language = {de} } @misc{Woop2009, author = {Woop, Gerry}, title = {Bentley der Politikpalette : Außenpolitik im Wahlkampf}, issn = {0944-8101}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32678}, year = {2009}, abstract = {Außenpolitik - h{\"a}ufig ein kontrovers diskutiertes Thema. Wie steht es mit der Offenlegung außenpolitischer Grunds{\"a}tze der Parteien in Zeiten des Wahlkampfes? Sollte man sich nur vorsichtig {\"a}ußern, um potentiellen Koalitionspartnern nicht vor den Kopf zu stoßen?}, language = {de} } @misc{Weidenfeld2009, author = {Weidenfeld, Werner}, title = {Kleine Schritte statt großer W{\"u}rfe : eine Bilanz schwarz-roter Europapolitik}, issn = {0944-8101}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32661}, year = {2009}, abstract = {Schwarz-Rot vertritt wie keine andere deutsche Regierung vor ihr selbstbewusst deutsche und europ{\"a}ische Interessen, ohne dieses Selbstbewusstsein bem{\"u}ht zur Schau zu stellen. Deutschland hat in den vergangenen Jahren ganz selbstverst{\"a}ndlich die Rolle des Antreibers europ{\"a}ischer Politik f{\"u}r sich reklamiert. Jedoch erwiesen sich Merkel und Steinmeier dabei mehr als realistische Pragmatiker denn als Vision{\"a}re.}, language = {de} } @book{PolyvyanyySmirnovWeske2008, author = {Polyvyanyy, Artem and Smirnov, Sergey and Weske, Mathias}, title = {The triconnected abstraction of process models}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-940793-65-2}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32847}, publisher = {Universit{\"a}t Potsdam}, pages = {17}, year = {2008}, abstract = {Contents: Artem Polyvanny, Sergey Smirnow, and Mathias Weske The Triconnected Abstraction of Process Models 1 Introduction 2 Business Process Model Abstraction 3 Preliminaries 4 Triconnected Decomposition 4.1 Basic Approach for Process Component Discovery 4.2 SPQR-Tree Decomposition 4.3 SPQR-Tree Fragments in the Context of Process Models 5 Triconnected Abstraction 5.1 Abstraction Rules 5.2 Abstraction Algorithm 6 Related Work and Conclusions}, language = {en} } @misc{DonnerStreckerRoessleretal.2009, author = {Donner, Stefanie and Strecker, Manfred and R{\"o}ßler, Dirk and Ghods, Abdolreza and Kr{\"u}ger, Frank and Landgraf, Angela and Ballato, Paolo}, title = {Earthquake source models for earthquakes in Northern Iran}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32581}, year = {2009}, abstract = {The complex system of strike-slip and thrust faults in the Alborz Mountains, Northern Iran, are not well understood yet. Mainly structural and geomorphic data are available so far. As a more extensive base for seismotectonic studies and seismic hazard analysis we plan to do a comprehensive seismic moment tensor study also from smaller magnitudes (M < 4.5) by developing a new algorithm. Here, we present first preliminary results.}, language = {en} } @phdthesis{Popov2008, author = {Popov, Anton}, title = {Three-dimensional thermo-mechanical modeling of deformation at plate boundaries : case study San Andreas Fault System}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-31875}, school = {Universit{\"a}t Potsdam}, year = {2008}, abstract = {It has always been enigmatic which processes control the accretion of the North American terranes towards the Pacific plate and the landward migration of the San Andreas plate boundary. One of the theories suggests that the Pacific plate first cools and captures the uprising mantle in the slab window, and then it causes the accretion of the continental crustal blocks. The alternative theory attributes the accretion to the capture of Farallon plate fragments (microplates) stalled in the ceased Farallon-North America subduction zone. Quantitative judgement between these two end-member concepts requires a 3D thermomechanical numerical modeling. However, the software tool required for such modeling is not available at present in the geodynamic modeling community. The major aim of the presented work is comprised basically of two interconnected tasks. The first task is the development and testing of the research Finite Element code with sufficiently advanced facilities to perform the three-dimensional geological time scale simulations of lithospheric deformation. The second task consists in the application of the developed tool to the Neogene deformations of the crust and the mantle along the San Andreas Fault System in Central and northern California. The geological time scale modeling of lithospheric deformation poses numerous conceptual and implementation challenges for the software tools. Among them is the necessity to handle the brittle-ductile transition within the single computational domain, adequately represent the rock rheology in a broad range of temperatures and stresses, and resolve the extreme deformations of the free surface and internal boundaries. In the framework of this thesis the new Finite Element code (SLIM3D) has been successfully developed and tested. This code includes a coupled thermo-mechanical treatment of deformation processes and allows for an elasto-visco-plastic rheology with diffusion, dislocation and Peierls creep mechanisms and Mohr-Coulomb plasticity. The code incorporates an Arbitrary Lagrangian Eulerian formulation with free surface and Winkler boundary conditions. The modeling technique developed is used to study the aspects influencing the Neogene lithospheric deformation in central and northern California. The model setup is focused on the interaction between three major tectonic elements in the region: the North America plate, the Pacific plate and the Gorda plate, which join together near the Mendocino Triple Junction. Among the modeled effects is the influence of asthenosphere upwelling in the opening slab window on the overlying North American plate. The models also incorporate the captured microplate remnants in the fossil Farallon subduction zone, simplified subducting Gorda slab, and prominent crustal heterogeneity such as the Salinian block. The results show that heating of the mantle roots beneath the older fault zones and the transpression related to fault stepping, altogether, render cooling in the slab window alone incapable to explain eastward migration of the plate boundary. From the viewpoint of the thermomechanical modeling, the results confirm the geological concept, which assumes that a series of microplate capture events has been the primary reason of the inland migration of the San Andreas plate boundary over the recent 20 Ma. The remnants of the Farallon slab, stalled in the fossil subduction zone, create much stronger heterogeneity in the mantle than the cooling of the uprising asthenosphere, providing the more efficient and direct way for transferring the North American terranes to Pacific plate. The models demonstrate that a high effective friction coefficient on major faults fails to predict the distinct zones of strain localization in the brittle crust. The magnitude of friction coefficient inferred from the modeling is about 0.075, which is far less than typical values 0.6 - 0.8 obtained by variety of borehole stress measurements and laboratory data. Therefore, the model results presented in this thesis provide additional independent constrain which supports the "weak-fault" hypothesis in the long-term ongoing debate over the strength of major faults in the SAFS.}, language = {en} } @article{Frank2009, author = {Frank, Ulrike}, title = {Therapie bei tracheotomierten Patienten mit schwerer Dysphagie}, series = {Spektrum Patholinguistik}, volume = {2}, journal = {Spektrum Patholinguistik}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1866-9085}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32654}, pages = {95 -- 112}, year = {2009}, abstract = {Inhalt: 1. Einleitung 2. Fragestellungen 3. Methoden 3.1 Methodisches Vorgehen: Interdisziplin{\"a}re Trachealkan{\"u}lenentw{\"o}hnung und Dekan{\"u}lierungsentscheidung im Basler Ansatz 3.2 Methodisches Vorgehen: Probanden und Messverfahren 4. Ergebnisse 4.1 Effektivit{\"a}t und Effizienz des multidisziplin{\"a}ren Ansatzes: Dekan{\"u}lierungs- und Komplikationsraten und Therapiedauer bis zur Dekan{\"u}lierung 4.2 Einfluss der Dekan{\"u}lierung auf den Rehabilitationsverlauf funktioneller F{\"a}higkeiten: Vergleich der funktionellen Selbst{\"a}ndigkeit vor vs. nach der Dekan{\"u}lierung 4.3 Entwicklung der Schluckfunktion und oralen Nahrungsaufnahme nach der Dekan{\"u}lierung 5. Diskussion 6. Fazit 7. Literatur 8. Danksagung}, language = {de} } @article{Kulik2009, author = {Kulik, Sylvia}, title = {..., dass einen der Satzbau immer wieder {\"u}berraschen kann}, series = {Spektrum Patholinguistik}, volume = {2}, journal = {Spektrum Patholinguistik}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1866-9433}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32647}, pages = {79 -- 94}, year = {2009}, language = {de} } @article{Wotschack2009, author = {Wotschack, Christiane}, title = {Zum Einfluss von Lesestrategien auf Effekte der kognitiven Kontrolle}, series = {Spektrum Patholinguistik}, volume = {2}, journal = {Spektrum Patholinguistik}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1866-9085}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32636}, pages = {69 -- 78}, year = {2009}, abstract = {Inhalt: 1. Einleitung 1.1 Blickbewegungen beim Lesen 1.2 Kognitive Kontrolle und verteilte Verarbeitung 2. Fragestellungen und Hypothesen 3. Methoden 3.1 Probanden 3.2 Material 3.3 Durchf{\"u}hrung und Auswertung 4. Ergebnisse 4.1 Unterschiede in Effekten der Wortvorhersagbarkeit 4.2 Unterschiede in Effekten der Wortfrequenz 5. Diskussion 6. Literatur}, language = {de} } @article{Grimm2009, author = {Grimm, Angela}, title = {Die Entwicklung des Prosodischen Wortes im Deutschen}, series = {Spektrum Patholinguistik}, volume = {2}, journal = {Spektrum Patholinguistik}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1866-9433}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32628}, pages = {51 -- 68}, year = {2009}, abstract = {Inhalt: 1. Einleitung 2. Hintergrund 2.1 Die prosodische Organisation des Deutschen 2.2 Implikationen f{\"u}r den Erwerb der Wortprosodie im Deutschen 3. Methode 3.1 Datenerhebung 3.2 Empirische Analyse 4. Ergebnisse: Die Entwicklung des Prosodischen Wortes im Deutschen 5. Analyse der empirischen Daten 5.1 Grundannahmen 5.2 Analyse der Entwicklungsstufen 6. Zusammenfassung und Diskussion 7. Literatur}, language = {de} } @article{TriarchiHerrmann2009, author = {Triarchi-Herrmann, Vassilia}, title = {Zur F{\"o}rderung und Therapie der Sprache bei Mehrsprachigkeit}, series = {Spektrum Patholinguistik}, volume = {2}, journal = {Spektrum Patholinguistik}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1866-9085}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32611}, pages = {31 -- 50}, year = {2009}, abstract = {Inhalt: 1. Einf{\"u}hrung 2. Sprachf{\"o}rderung von mehrsprachigen Kindern 2.1 Sprachf{\"o}rdermaßnahmen 2.2 Qualit{\"a}tskriterien bei einer Sprachf{\"o}rderung 3. Sprachdiagnostik 3.1 Sprachtherapie mehrsprachiger Kinder 3.2 Differentialdiagnostik 4. Zusammenfassung 5. Literatur}, language = {de} } @article{Wahl2009, author = {Wahl, Michael}, title = {Zwei Sprachen = Zwei Systeme?}, series = {Spektrum Patholinguistik}, volume = {2}, journal = {Spektrum Patholinguistik}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1866-9433}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32602}, pages = {9 -- 30}, year = {2009}, abstract = {Inhalt: 1. Einf{\"u}hrung 1.1 Methoden zur Untersuchung sprachlicher F{\"a}higkeiten 1.2 Die Anf{\"a}nge der Erforschung von Mehrsprachigkeit 2. Funktionelle Bildgebung 2.1 Einfluss des Erwerbsalters 2.2 Einfluss der Sprachkompetenz 3. Elektrophysiologische Daten 3.1 Einfluss des Erwerbsalters 3.2 Einfluss der Sprachkompetenz 4. Neurokognitive Modelle 4.1 Lexikalisch-semantische Modelle 4.2 Lexikalisch-Grammatikalisches Modell 4.3 Implizit-Explizites Modell 5. Schlussfolgerung 6. Literatur}, language = {de} } @article{Heide2009, author = {Heide, Judith}, title = {Mehrsprachigkeit in der fr{\"u}hen Kindheit}, series = {Spektrum Patholinguistik}, volume = {2}, journal = {Spektrum Patholinguistik}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1866-9085}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32597}, pages = {1 -- 8}, year = {2009}, abstract = {Inhalt: - 1. Mythos Mehrsprachigkeit - 2. „Ein Kopf - ein Chor": Sprachmischung bei bilingualen Sprechern - 3. Doppelter Erstspracherwerb (2L1) - 4. Fr{\"u}her L2-Erwerb - 5. Quellen im Text - 6. Literaturempfehlungen von Prof. Dr. Rosemarie Tracy}, language = {de} } @misc{TracyHeideWahletal.2009, author = {Tracy, Rosemarie and Heide, Judith and Wahl, Michael and Triarchi-Herrmann, Vassilia and Grimm, Angela and Wotschack, Christiane and Kulik, Sylvia and Frank, Ulrike and Klassert, Annegret and Gagarina, Natalʹja Vladimirovna and Kauschke, Christina and Eicher, Iris and Tsakmaki, Barbara and Akkaya, Zeynep and Castillo, Esmeralda and Groba, Agnes and H{\"o}hle, Barbara and Miertsch, Barbara and Hubert, Anja and Sauerland, Uli and Schr{\"o}der, Caroline and Stadie, Nicole and Wittler, Marion and Berendes, Karin and Gottal, Stephanie and Grabherr, Britta and Zaps, Jennifer and Ptok, Martin and Hanne, Sandra and Sekerina, Irina A. and Vasishth, Shravan and Burchert, Frank and De Bleser, Ria and Kleissendorf, Barbara and Jaecks, Petra and Stenneken, Prisca and Fischer, Ivette and Moedebeck, Petra}, title = {Spektrum Patholinguistik = Schwerpunktthema: Ein Kopf - Zwei Sprachen : Mehrsprachigkeit in Forschung und Therapie}, number = {2}, editor = {Heide, Judith and Hanne, Sandra and Brandt-Kobele, Oda-Christina and Fritzsche, Tom}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, organization = {Verband f{\"u}r Patholinguistik e. V. (vpl)}, isbn = {978-3-940793-89-8}, issn = {1869-3822}, doi = {10.25932/publishup-3086}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-30451}, year = {2009}, abstract = {"Spektrum Patholinguistik" (Band 2) ist der Tagungsband zum 2. Herbsttreffen Patholinguistik, das der Verband f{\"u}r Patholinguistik (vpl) e.V. am 22.11.2008 an der Universit{\"a}t Potsdam veranstaltet hat. Zum Schwerpunktthema "Ein Kopf - Zwei Sprachen: Mehrsprachigkeit in Forschung und Therapie" sind die drei Hauptvortr{\"a}ge und vier Abstracts von Posterpr{\"a}sentationen ver{\"o}ffentlicht. Desweiteren enth{\"a}lt der Tagungsband freie Beitr{\"a}ge, u.a. zu Satzverarbeitung und Agrammatismus, Lesestrategien und LRS, Prosodie-Entwicklung, kindlichen Aphasien, Dysphagie-Therapie sowie zu kognitiven Defiziten bei {\"a}lteren Menschen.}, language = {de} } @phdthesis{Dreja2009, author = {Dreja, Tanja S.}, title = {Microarray-basierte Expressionsanalysen des weißen Fettgewebes der NZO-Maus sowie der Langerhansschen Inseln der NZL-Maus : zwei Modelle f{\"u}r das metabolische Syndrom}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32379}, school = {Universit{\"a}t Potsdam}, year = {2009}, abstract = {{\"U}bergewicht und Adipositas f{\"u}hren zu Insulinresistenz und erh{\"o}hen deutlich das Risiko f{\"u}r die Entwicklung von Typ-2-Diabetes und kardiovaskul{\"a}ren Erkrankungen. Sowohl Adipositas als auch die Suszeptibilit{\"a}t gegen{\"u}ber Diabetes sind zu einem erheblichen Teil genetisch determiniert. Die relevanten Risikogene, deren Interaktion mit der Umwelt, insbesondere mit Bestandteilen der Nahrung, und die Pathomechanismen, die zur Insulinresistenz und Diabetes f{\"u}hren, sind nicht vollst{\"a}ndig aufgekl{\"a}rt. In der vorliegenden Arbeit sollte durch Genexpressionsanalysen des weißen Fettgewebes (WAT) und der Langerhansschen Inseln die Entstehung und Progression von Adipositas und Typ-2-Diabetes untersucht werden, um relevante Pathomechanismen und neue Kandidatengene zu identifizieren. Zu diesem Zweck wurden Di{\"a}t-Interventionsstudien mit NZO- und verwandten NZL-M{\"a}usen, zwei polygenen Mausmodellen f{\"u}r das humane metabolische Syndrom, durchgef{\"u}hrt. Eine kohlenhydrathaltige Hochfett-Di{\"a}t (HF: 14,6 \% Fettanteil) f{\"u}hrte in beiden Mausmodellen zu fr{\"u}her Adipositas, Insulinresistenz und Typ 2 Diabetes. Eine fettreduzierte Standarddi{\"a}t (SD: 3,3 \% Fettanteil), welche die Entstehung von Adipositas und Diabetes stark verz{\"o}gert, sowie eine diabetesprotektive kohlenhydratfreie Hochfett-Di{\"a}t (CHF: 30,2 \% Fettanteil) dienten als Kontrolldi{\"a}ten. Mit Hilfe der Microarray-Technologie wurden genomweite Expressionsprofile des WAT erstellt. Pankreatische Inseln wurden durch laserbasierte Mikropr{\"a}paration (Laser Capture Microdissection; LCM) isoliert und ebenfalls hinsichtlich ihres Expressionsprofils analysiert. Differenziell exprimierte Gene wurden durch Real-Time-PCR validiert. Im WAT der NZO-Maus bewirkte die HF-Di{\"a}t eine reduzierte Expression nukle{\"a}rer Gene der oxidativen Phosphorylierung und von lipogenen Enzymen. Dies deutet auf eine inad{\"a}quate Fettspeicherung und -verwertung in diesen Tieren hin. Die Reduktion in der Fettspeicherung und -oxidation ist spezifisch f{\"u}r das adip{\"o}se NZO-Modell und konnte bei der schlanken SJL Maus nicht beobachtet werden, was auf eine m{\"o}gliche Beteiligung an der Entstehung der Insulinresistenz hinweist. Zus{\"a}tzlich wurde best{\"a}tigt, dass die Expansion des Fettgewebes bei der adip{\"o}sen NZO-Maus eine zeitlich verz{\"o}gerte Infiltration von Makrophagen in das WAT und dort eine lokale Immunantwort ausl{\"o}st. Dar{\"u}ber hinaus wurde die Methode der LCM etabliert und zur Gewinnung hochangereicherter RNA aus den Langerhansschen Inseln eingesetzt. In erstmalig durchgef{\"u}hrten genomweiten Expressionsanalysen wurde zu einem fr{\"u}hen Zeitpunkt in der Diabetesentwicklung der Einfluss einer diabetogenen HF-Di{\"a}t und einer diabetesprotektiven CHF-Di{\"a}t auf das Expressionsprofil von pankreatischen Inselzellen verglichen. Im Gegensatz zum WAT bewirkt die diabetogene HF-Di{\"a}t in Inselzellen einerseits, eine erh{\"o}hte Expression von nukle{\"a}ren Genen f{\"u}r die oxidative Phosphorylierung und andererseits von Genen, die mit Zellproliferation assoziiert sind. Zudem wurden 37 bereits annotierte Gene identifiziert, deren differenzielle Expression mit der Diabetesentwicklung korreliert. Das Peptidhormon Cholecystokinin (Cck, 11,8-fach erh{\"o}ht durch die HF) stellt eines der am st{\"a}rksten herauf regulierten Gene dar. Die hohe Anreicherung der Cck-mRNA in Inselzellen deutet auf eine bisher unbekannte Funktion des Hormons in der Regulation der Inselzellproliferation hin. Der Transkriptionsfaktor Mlxipl (ChREBP; 3,8-fach erniedrigt durch die HF) stellt in Langerhansschen Inseln eines der am st{\"a}rksten herunter regulierten Gene dar. Ferner wurde ChREBP, dessen Funktion als glucoseregulierter Transkriptionsfaktor f{\"u}r lipogene Enzyme bislang in der Leber, aber nicht in Inselzellen nachgewiesen werden konnte, erstmals immunhistochemisch in Inselzellen detektiert. Dies deutet auf eine neue, bisher unbekannte regulatorische Funktion von ChREBP im Glucosesensor-Mechanismus der Inselzellen hin. Eine durchgef{\"u}hrte Korrelation der mit der Diabetesentwicklung assoziierten, differenziell exprimierten Inselzellgene mit Genvarianten aus humanen genomweiten Assoziationsstudien f{\"u}r Typ-2-Diabetes (WTCCC, Broad-DGI-T2D-Studie) erm{\"o}glichte die Identifizierung von 24 neuartigen Diabetes-Kandidatengenen. Die Ergebnisse der erstmals am polygenen NZO-Mausmodell durchgef{\"u}hrten genomweiten Expressionsuntersuchungen best{\"a}tigen bisherige Befunde aus Mausmodellen f{\"u}r Adipositas und Diabetes (z.B. ob/ob- und db/db-M{\"a}use), zeigen in einigen F{\"a}llen aber auch Unterschiede auf. Insbesondere in der oxidativen Phosphorylierung k{\"o}nnten die Ergebnisse relevant sein f{\"u}r das Verst{\"a}ndnis der Pathogenese des polygen-bedingten humanen metabolischen Syndroms.}, language = {de} } @phdthesis{Kristen2009, author = {Kristen, Iris}, title = {Investigations on rainfall variability during the late Quaternary based on geochemical analyses of lake sediments from tropical and subtropical southern Africa}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32547}, school = {Universit{\"a}t Potsdam}, year = {2009}, abstract = {This thesis presents investigations on sediments from two African lakes which have been recording changes in their surrounding environmental and climate conditions since more than 200,000 years. Focus of this work is the time of the last Glacial and the Holocene (the last ~100,000 years before present [in the following 100 kyr BP]). One important precondition for this kind of research is a good understanding of the present ecosystems in and around the lakes and of the sediment formation under modern climate conditions. Both studies therefore include investigations on the modern environment (including organisms, soils, rocks, lake water and sediments). A 90 m long sediment sequence was investigated from Lake Tswaing (north-eastern South Africa) using geochemical analyses. These investigations document alternating periods of high detrital input and low (especially autochthonous) organic matter content and periods of low detrital input, carbonatic or evaporitic sedimentation and high autochthonous organic matter content. These alternations are interpreted as changes between relatively humid and arid conditions, respectively. Before c. 75 kyr BP, they seem to follow changes in local insolation whereas afterwards they appear to be acyclic and are probably caused by changes in ocean circulation and/or in the mean position of the Inter-Tropical Convergence Zone (ITCZ). Today, these factors have main influence on precipitation in this area where rainfall occurs almost exclusively during austral summer. All modern organisms were analysed for their biomarker and bulk organic and compound-specific stable carbon isotope composition. The same investigations on sediments from the modern lake floor document the mixed input of the investigated individual organisms and reveal additional influences by methanotrophic bacteria. A comparison of modern sediment characteristics with those of sediments covering the time 14 to 2 kyr BP shows changes in the productivity of the lake and the surrounding vegetation which are best explained by changes in hydrology. More humid conditions are indicated for times older than 10 kyr BP and younger than 7.5 kyr BP, whereas arid conditions prevailed in between. These observations agree with the results from sediment composition and indications from other climate archives nearby. The second lake study deals with Lake Challa, a small, deep crater lake on the foot of Mount Kilimanjaro. In this lake form mm-scale laminated sediments which were analyses with micro-XRF scanning for changes in the element composition. By comparing these results with investigations on thin sections, results from ongoing sediment trap studies, meteorological data, and investigations on the surrounding rocks and soils, I develop a model for seasonal variability in the limnology and sedimentation of Lake Challa. The lake appears to be stratified during the warm rain seasons (October - December and March - May) during which detrital material is delivered to the lake and carbonates precipitate. On the lake floor forms a dark lamina with high contents of Fe and Ti and high Ca/Al and low Mn/Fe ratios. Diatoms bloom during the cool and windy season (June - September) when mixing down to c. 60 m depth provides easily bio-available nutrients. Contemporaneously, Fe and Mn-oxides are precipitating which cause high Mn/Fe ratios in the light diatom-rich laminae of the sediments. Trends in the Mn/Fe ratio of the sediments are interpreted to reflect changes in the intensity or duration of seasonal mixing in Lake Challa. This interpretation is supported by parallel changes in the organic matter and biogenic silica content observed in the 22 m long profile recovered from Lake Challa. This covers the time of the last 25 kyr BP. It documents a transition around 16 kyr BP from relatively well-mixed conditions with high detrital input during glacial times to stronger stratified conditions which are probably related to increasing lake levels in Challa and generally more humid conditions in East Africa. Intensified mixing is recorded for the time of the Younger Dryas and the period between 11.4 and 10.7 kyr BP. For these periods, reduced intensity of the SW monsoon and intensified NE monsoon are reported from archives of the Indian-Asian Monsoon region, arguing for the latter as a probable source for wind mixing in Lake Challa. This connection is probably also responsible for contemporaneous events in the Mn/Fe ratios of the Lake Challa sediments and in other records of northern hemisphere monsoon intensity during the Holocene and underlines the close interaction of global low latitude atmospheric circulation.}, language = {en} } @misc{OPUS4-3083, title = {Renaissance Linguistics Archive (1.0)}, editor = {Tavoni, Mirko and Flood, John and Lardet, Pierre and Haßler, Gerda and Damis-Sch{\"a}fer, Christine and Van Hal, Toon}, isbn = {978-3-940793-99-7}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32068}, pages = {3605}, year = {2009}, abstract = {The bibliographic project 'Renaissance Linguistics Archive' (R.L.A.) aimed at establishing a comprehensive database of secondary sources covering the linguistics ideas developed by Renaissance scholars in Europe. The database project, founded in 1986 by Mirko Tavoni (Pisa) and in 1994 transferred to Gerda Haßler (Potsdam), resulted so far in three print-outs, each of them counting 1000 records. It is the aim of this website to publish the results of the collective efforts undertaken thus far (R.L.A. 1.0, 1986-1999).}, language = {en} } @book{Birkholz2006, author = {Birkholz, Kai}, title = {Kommunales Debt Management in Deutschland}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-939469-05-6}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32521}, publisher = {Universit{\"a}t Potsdam}, pages = {41}, year = {2006}, abstract = {Inhalt: 1. Untersuchungsfeld 2. Allgemeine Angaben zu den befragten Kommunen 2.1 Haushaltsdefizit/-{\"u}berschuss 2.2. Schuldenstand zum 31.12.2004 und Zinsausgaben 2.3. Durchschnittsverzinsung 3. Kommunales Debt Management 3.1. Zielsetzungen 3.2. Kreditmanagement 3.3. Derivatemanagement 3.4. Organisatorische Aspekte 4. Fazit}, language = {de} } @book{Dittrich2009, author = {Dittrich, Matthias}, title = {Folgenabsch{\"a}tzung von Gesetzen in Großbritannien}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-31948}, publisher = {Universit{\"a}t Potsdam}, year = {2009}, abstract = {Der Aufsatz stellt den Stand der Institutionalisierung von Folgenabsch{\"a}tzungen im Prozess der Gesetzeserstellung in der Exekutive in Großbritannien dar.}, language = {de} } @article{Vogel2004, author = {Vogel, Ralf}, title = {Dialectal variation in German 3-verb clusters}, series = {Linguistics in Potsdam}, volume = {22}, journal = {Linguistics in Potsdam}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1864-1857}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32516}, pages = {83 -- 118}, year = {2004}, abstract = {Content: 1 The Typology 1.1 Object Placement 2 Treatment of StG in terms of LF Movement - with and without Head Movement 3 An OT-solution in terms of linearisation ('LF-to-PF-Mapping') 3.1 The trigger for additional orders: Focus 3.2 Competitions 3.3 Summary 4 RP 4.1 LF Movement - with and without Head Movement 4.2 The OT-account for RP 4.3 Competitions 5 Summary}, language = {en} } @article{Meinunger2004, author = {Meinunger, Andr{\´e}}, title = {Interface restrictions on verb second}, series = {Linguistics in Potsdam}, volume = {22}, journal = {Linguistics in Potsdam}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1616-7392}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32502}, pages = {51 -- 81}, year = {2004}, abstract = {Content: 0 Introduction 1 Elements that block verb raising - a discussion 1.1 Haider's observation 1.2 The other constructions 1.3 A possible explanation 1.4 Riemsdijk's grafting approach as a possible alternative? 1.5 Intermediate Summary 2 Parsing problems with speech act adverbials in the pre-field}, language = {en} } @article{Fanselow2004, author = {Fanselow, Gisbert}, title = {M{\"u}nchhausen-style head movement and the analysis of verb second}, series = {Linguistics in Potsdam}, volume = {22}, journal = {Linguistics in Potsdam}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1864-1857}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32497}, pages = {9 -- 49}, year = {2004}, abstract = {Content: 1 Introduction 2 A restrictive theory of head movement 2.1 Preliminary Remarks 2.2 Theoretical Problems of Head Movement 2.3 Remnant Phrasal Movement 2.4 M{\"u}nchhausen Style Head Movement 3 Verb Second Movement 3.1 Introductory Remarks 3.2 Problems of V/2 constructions: Does V really move to Comp? 3.3 The preverbal position 3.4 The Second Position 4 References}, language = {en} } @article{TrutkowskiZugckBlaszczaketal.2003, author = {Trutkowski, Ewa and Zugck, Marco and Blaszczak, Joanna and Fanselow, Gisbert and Fischer, Susann and Vogel, Ralf}, title = {Superiorit{\"a}t in europ{\"a}ischen Sprachen}, series = {Linguistics in Potsdam}, volume = {21}, journal = {Linguistics in Potsdam}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1616-7392}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32485}, pages = {123 -- 137}, year = {2003}, abstract = {Inhalt: 1. Superiorit{\"a}t in einfachen S{\"a}tzen 2. Transitive S{\"a}tze mit Dativ-Objekten 3. Effekte durch extrem markierte Abfolgen?}, language = {de} } @article{VogelZugck2003, author = {Vogel, Ralf and Zugck, Marco}, title = {Counting Markedness}, series = {Linguistics in Potsdam}, volume = {21}, journal = {Linguistics in Potsdam}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1864-1857}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32476}, pages = {105 -- 122}, year = {2003}, abstract = {This paper reports the results of a corpus investigation on case conflicts in German argument free relative constructions. We investigate how corpus frequencies reflect the relative markedness of free relative and correlative constructions, the relative markedness of different case conflict configurations, and the relative markedness of different conflict resolution strategies. Section 1 introduces the conception of markedness as used in Optimality Theory. Section 2 introduces the facts about German free relative clauses, and section 3 presents the results of the corpus study. By and large, markedness and frequency go hand in hand. However, configurations at the highest end of the markedness scale rarely show up in corpus data, and for the configuration at the lowest end we found an unexpected outcome: the more marked structure is preferred.}, language = {en} } @article{VogelFrisch2003, author = {Vogel, Ralf and Frisch, Stefan}, title = {The resolution of case conflicts}, series = {Linguistics in Potsdam}, volume = {21}, journal = {Linguistics in Potsdam}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1616-7392}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32466}, pages = {91 -- 103}, year = {2003}, abstract = {This paper reports the results of a pilot study on the resolution of case conflicts in German free relative constructions. Section 1 gives a brief introduction into the phenomenon, section 2 presents the experiment and its results, section 3 ends the paper with a brief more general discussion.}, language = {en} } @article{Fischer2003, author = {Fischer, Susann}, title = {Partitive vs. Genitive in Russian and Polish}, series = {Linguistics in Potsdam}, journal = {Linguistics in Potsdam}, number = {21}, issn = {1616-7392}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32457}, pages = {73 -- 89}, year = {2003}, abstract = {The present paper addresses a current view in the psycholinguistic literature that case exhibits processing properties distinct from those of other morphological features such as number (cf. Fodor \& Inoue, 2000; Meng \& Bader, 2000a/b). In a speeded-acceptability judgement experiment, we show that the low performance previously found for case in contrast to number violations is limited to nominative case, whereas violations involving accusative and dative are judged more accurately. The data thus do not support the proposal that case per se is associated with special properties (in contrast to other features such as number) in reanalysis processes. Rather, there are significant judgement differences between the object cases accusative and dative on the one hand and the subject nominative case on the other. This may be explained by the fact that nominative has a specific status in German (and many other languages) as a default case.}, language = {en} } @article{SchlesewskyFrisch2003, author = {Schlesewsky, Matthias and Frisch, Stefan}, title = {Nominative case as a multidimensional default}, series = {Linguistics in Potsdam}, journal = {Linguistics in Potsdam}, number = {21}, issn = {1616-7392}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32447}, pages = {61 -- 72}, year = {2003}, abstract = {The present paper addresses a current view in the psycholinguistic literature that case exhibits processing properties distinct from those of other morphological features such as number (cf. Fodor \& Inoue, 2000; Meng \& Bader, 2000a/b). In a speeded-acceptability judgement experiment, we show that the low performance previously found for case in contrast to number violations is limited to nominative case, whereas violations involving accusative and dative are judged more accurately. The data thus do not support the proposal that case per se is associated with special properties (in contrast to other features such as number) in reanalysis processes. Rather, there are significant judgement differences between the object cases accusative and dative on the one hand and the subject nominative case on the other. This may be explained by the fact that nominative has a specific status in German (and many other languages) as a default case.}, language = {en} } @article{SchlesewskyFanselowFrisch2003, author = {Schlesewsky, Matthias and Fanselow, Gisbert and Frisch, Stefan}, title = {Case as a trigger for reanalysis}, series = {Linguistics in Potsdam}, journal = {Linguistics in Potsdam}, number = {21}, issn = {1616-7392}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32431}, pages = {31 -- 60}, year = {2003}, abstract = {In the recent literature there is a hypothesis that the human parser uses number and case information in different ways to resolve an initially incorrect case assignment. This paper investigates what role morphological case information plays during the parser's detection of an ungrammaticality or its recognition that a reanalysis is necessary. First, we compare double nominative with double accusative ungrammaticalities in a word by word, speeded grammaticality task and in this way show that only double nominatives lead to a so-called "illusion of grammaticality" (a low rate of ungrammaticality detection). This illusion was found to disappear when the second argument was realized by a pronoun rather than by a full definite determiner phrase, i.e. when the saliency of the second argument was increased. Thus, the accuracy in recognizing an ungrammaticality induced by the case feature of the second argument is dependent on the type of this argument. Furthermore, we found that the accuracy in detecting such case ungrammaticalities is distance sensitive insofar as a shorter distance leads to a higher accuracy. The results are taken as support for an "expectationdriven" parse strategy in which the way the parser uses the information of a current input item depends on the expectation resulting from the parse carried out so far. By contrast, "input-driven" parse strategies, such as the diagnosis model (Fodor \& Inoue, 1999) are unable to explain the data presented here.}, language = {en} } @phdthesis{Grimbs2009, author = {Grimbs, Sergio}, title = {Towards structure and dynamics of metabolic networks}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32397}, school = {Universit{\"a}t Potsdam}, year = {2009}, abstract = {This work presents mathematical and computational approaches to cover various aspects of metabolic network modelling, especially regarding the limited availability of detailed kinetic knowledge on reaction rates. It is shown that precise mathematical formulations of problems are needed i) to find appropriate and, if possible, efficient algorithms to solve them, and ii) to determine the quality of the found approximate solutions. Furthermore, some means are introduced to gain insights on dynamic properties of metabolic networks either directly from the network structure or by additionally incorporating steady-state information. Finally, an approach to identify key reactions in a metabolic networks is introduced, which helps to develop simple yet useful kinetic models. The rise of novel techniques renders genome sequencing increasingly fast and cheap. In the near future, this will allow to analyze biological networks not only for species but also for individuals. Hence, automatic reconstruction of metabolic networks provides itself as a means for evaluating this huge amount of experimental data. A mathematical formulation as an optimization problem is presented, taking into account existing knowledge and experimental data as well as the probabilistic predictions of various bioinformatical methods. The reconstructed networks are optimized for having large connected components of high accuracy, hence avoiding fragmentation into small isolated subnetworks. The usefulness of this formalism is exemplified on the reconstruction of the sucrose biosynthesis pathway in Chlamydomonas reinhardtii. The problem is shown to be computationally demanding and therefore necessitates efficient approximation algorithms. The problem of minimal nutrient requirements for genome-scale metabolic networks is analyzed. Given a metabolic network and a set of target metabolites, the inverse scope problem has as it objective determining a minimal set of metabolites that have to be provided in order to produce the target metabolites. These target metabolites might stem from experimental measurements and therefore are known to be produced by the metabolic network under study, or are given as the desired end-products of a biotechological application. The inverse scope problem is shown to be computationally hard to solve. However, I assume that the complexity strongly depends on the number of directed cycles within the metabolic network. This might guide the development of efficient approximation algorithms. Assuming mass-action kinetics, chemical reaction network theory (CRNT) allows for eliciting conclusions about multistability directly from the structure of metabolic networks. Although CRNT is based on mass-action kinetics originally, it is shown how to incorporate further reaction schemes by emulating molecular enzyme mechanisms. CRNT is used to compare several models of the Calvin cycle, which differ in size and level of abstraction. Definite results are obtained for small models, but the available set of theorems and algorithms provided by CRNT can not be applied to larger models due to the computational limitations of the currently available implementations of the provided algorithms. Given the stoichiometry of a metabolic network together with steady-state fluxes and concentrations, structural kinetic modelling allows to analyze the dynamic behavior of the metabolic network, even if the explicit rate equations are not known. In particular, this sampling approach is used to study the stabilizing effects of allosteric regulation in a model of human erythrocytes. Furthermore, the reactions of that model can be ranked according to their impact on stability of the steady state. The most important reactions in that respect are identified as hexokinase, phosphofructokinase and pyruvate kinase, which are known to be highly regulated and almost irreversible. Kinetic modelling approaches using standard rate equations are compared and evaluated against reference models for erythrocytes and hepatocytes. The results from this simplified kinetic models can simulate acceptably the temporal behavior for small changes around a given steady state, but fail to capture important characteristics for larger changes. The aforementioned approach to rank reactions according to their influence on stability is used to identify a small number of key reactions. These reactions are modelled in detail, including knowledge about allosteric regulation, while all other reactions were still described by simplified reaction rates. These so-called hybrid models can capture the characteristics of the reference models significantly better than the simplified models alone. The resulting hybrid models might serve as a good starting point for kinetic modelling of genome-scale metabolic networks, as they provide reasonable results in the absence of experimental data, regarding, for instance, allosteric regulations, for a vast majority of enzymatic reactions.}, language = {en} } @article{Kuegler2003, author = {K{\"u}gler, Frank}, title = {Do we know the answer?}, series = {Linguistics in Potsdam}, journal = {Linguistics in Potsdam}, number = {21}, issn = {1616-7392}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32424}, pages = {9 -- 29}, year = {2003}, abstract = {Content: 1. Introduction 2. The corpus 2.1 Subjects 2.2 Recordings 2.3 Data processing 2.4 Materials 3. Intonation in Upper Saxon German yes-no-questions 4. Intonational variation and information structure 5. Conclusions and discussion}, language = {en} } @phdthesis{Michalk2009, author = {Michalk, Daniel M.}, title = {An appraisal of a new method for the full-vector reconstruction of the Earth's magnetic field - applied to volcanic rocks from Mexico}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-31868}, school = {Universit{\"a}t Potsdam}, year = {2009}, abstract = {Das Magnetfeld der Erde wird durch Konvektionsstr{\"o}mungen im elektrisch leitf{\"a}higen, fl{\"u}ssigen eisenreichen {\"a}ußeren Erdkern erzeugt. Eine drastische Auspr{\"a}gung der dynamischen Prozesse im {\"a}ußeren Erdkern sind sowohl Polarit{\"a}tswechsel {\"u}ber geologische Zeitr{\"a}ume, als auch geomagnetische Feldexkursionen (kurze Umpolungen). Letztere sind in geologischen Archiven h{\"a}ufig unzureichend dokumentiert. F{\"u}r ein verbessertes Verst{\"a}ndnis {\"u}ber die Entwicklung des Erdmagnetfeldes in geologischer Vergangenheit ben{\"o}tigen wir Informationen {\"u}ber die Geometrie des gesamten Vektorfeldes, wof{\"u}r neben der Bestimmung der Feldrichtungen auch die Bestimmung der absoluten Pal{\"a}ointensit{\"a}t und des Alters notwendig ist. Insbesondere Vulkanite bieten die M{\"o}glichkeit, Daten {\"u}ber die Richtung und vor allem auch die Intensit{\"a}t des Erdmagnetfeldes zur Zeit ihrer Platznahme zu gewinnen. Bisweilen ist eine genaue Charakterisierung der Entwicklung des Erdmagnetfeldes in Zeit und Raum schwer m{\"o}glich, was sich in erster Linie auf den generellen Mangel an Pal{\"a}ointensit{\"a}tsdaten zur{\"u}ckf{\"u}hren l{\"a}sst. Ein Grund hierf{\"u}r ist, dass die meisten Methoden zur absoluten Pal{\"a}ointensit{\"a}tsbestimmung, auf Modifikationen der Thellier Methode basieren, welche nur auf magnetische Minerale im Einbereichs-Dom{\"a}nenzustand anwendbar ist und zudem hohe Ausschussraten liefert. Eine alternative Methode zur Bestimmung der absoluten Pal{\"a}ointensit{\"a}t ist die k{\"u}rzlich entwickelte „multispecimen parallel differential pTRM" (MS) Methode, welche im Vergleich zur Thellier Methode den Vorteil hat, dass sie theoretisch unabh{\"a}ngig ist vom Dom{\"a}nenzustand der magnetischen Minerale und somit auf alle Vulkanite anwendbar ist. Ein Schwerpunkt dieser Arbeit lag darauf, neue Informationen {\"u}ber das Auftreten und gegebenfalls die globale G{\"u}ltigkeit von geomagnetischen Feldexkursionen zu gewinnen. Hierf{\"u}r wurden etwa 75 Lavafl{\"u}sse des Transmexikanischen Vulkang{\"u}rtels f{\"u}r pal{\"a}omagnetische Studien beprobt. Eine Korrelation der mittleren Pal{\"a}orichtungen von 56 mexikanischen Laven mit einer um Feldexkursionen erg{\"a}nzten geomagnetischen Polarit{\"a}tszeitskala, lieferte Hinweise auf 4 Exkursionen. Ein bedeutendes Ergebnis dieser Arbeit sind ann{\"a}hrend komplett inversen Richtungen zweier Laven der Brunhes Chron. Dies gibt einen Hinweis darauf, dass diese Exkursionen kurze Zeitintervalle inverser Polarit{\"a}t mit globaler G{\"u}ltigkeit repr{\"a}sentieren k{\"o}nnten. Ein weiterer Schwerpunkt der vorliegenden Arbeit war, die neue MS Methode auf ihre Anwendbarkeit und Genauigkeit hin zu testen. Hierf{\"u}r wurden Pal{\"a}ointensit{\"a}tsexperimente an 11 historischen Laven aus Mexiko und Island durchgef{\"u}hrt. Ein Vergleich der Pal{\"a}ointensit{\"a}ten mit Daten von magnetischen Observatorien ergab, dass die MS Methode einen generellen Trend zur {\"U}bersch{\"a}tzung der Pal{\"a}ointensit{\"a}t aufweisst, welcher anhand von komplementierenden gesteinsmagnetischen Daten mit magnetischen Mineralen im Mehrbereichsteilchen-Zustand in Verbindung gebracht werden konnte. Diese Beobachtung liefert demnach einen ersten Beweis daf{\"u}r, dass die MS Methode m{\"o}glicherweise nicht wie urspr{\"u}nglich angenommen unabh{\"a}ngig vom Dom{\"a}nenzustand der Tr{\"a}germinerale ist. Im weiteren wurde eine Komplementierung der Richtungsdaten mexikanischer Laven durch absolute Pal{\"a}ointensit{\"a}tsbestimmungen angestrebt. Hierf{\"u}r wurde die MS Methode herangezogen und zum ersten Mal in großem Umfang auf Vulkanite mit Altern von bis zu 3,5 Millionen Jahre angewendet. Ein Vergleich mit Rekonstruktionen des Dipol-Momentes, welche auf den Daten der gegenw{\"a}rtigen globalen Pal{\"a}ointensit{\"a}tsdatanbasis basieren, ergaben, dass diese MS Daten mit hoher statistischer Wahrscheinlichkeit im Mittel etwa 30\% h{\"o}her sind. Die generell zu hohen Pal{\"a}onintensit{\"a}ten nach der MS Methode bekr{\"a}ftigen daher die Ergebnisse von historischen Laven dieser Arbeit, sowie anderer experimenteller Studien an synthetischen Proben, bei denen {\"U}bersch{\"a}tzungen von MS Pal{\"a}ointensit{\"a}ten von bis zu 30\% festgestellt wurden. Der Process, aus dem diese {\"U}bersch{\"a}tzung der Pal{\"a}ointensit{\"a}t resultiert ist eine Asymetrie des Entmagnetisierungs- und Remagnetisierungsprozesses heisst, dass ein effektives Entmagnetisieren w{\"a}hrend der Remagnetisierung im angelegten Laborfeld erfolgt. Diese Asymetrie scheint besonders bei pseudo-Einbereichsteilchen ausgepr{\"a}gt zu sein. Es wird allerdings davon ausgegangen, dass diese {\"U}bersch{\"a}tzung nicht gr{\"o}ßer ist, als was man bei einem Thellier Experiment an Proben mit {\"a}hnlicher magnetischer Korngr{\"o}ße erwarten w{\"u}rde.}, language = {en} } @phdthesis{Zamagni2009, author = {Zamagni, Jessica}, title = {Responses of a shallow-water ecosystem to the early Paleogene greenhouse environmental conditions : evolution of Larger Foraminifera and coral communities from the Northern Tethys}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-31853}, school = {Universit{\"a}t Potsdam}, year = {2009}, abstract = {Modern anthropogenic forcing of atmospheric chemistry poses the question of how the Earth System will respond as thousands of gigatons of greenhouse gas are rapidly added to the atmosphere. A similar, albeit nonanthropogenic, situation occurred during the early Paleogene, when catastrophic release of carbon to the atmosphere triggered abrupt increase in global temperatures. The best documented of these events is the Paleocene-Eocene Thermal Maximum (PETM, ~55 Ma) when the magnitude of carbon addition to the oceans and atmosphere was similar to those expected for the future. This event initiated global warming, changes in hydrological cycles, biotic extinction and migrations. A recently proposed hypothesis concerning changes in marine ecosystems suggests that this global warming strongly influenced the shallow-water biosphere, triggering extinctions and turnover in the Larger Foraminifera (LF) community and the demise of corals. The successions from the Adriatic Carbonate Platform (SW Slovenia) represent an ideal location to test the hypothesis of a possible causal link between the PETM and evolution of shallow-water organisms because they record continuous sedimentation from the Late Paleocene to the Early Eocene and are characterized by a rich biota, especially LF, fundamental for detailed biostratigraphic studies. In order to reconstruct paleoenvironmental conditions during deposition, I focused on sedimentological analysis and paleoecological study of benthic assemblages. During the Late Paleocene-earliest Eocene, sedimentation occurred on a shallow-water carbonate ramp system characterized by enhanced nutrient levels. LF represent the common constituent of the benthic assemblages that thrived in this setting throughout the Late Paleocene to the Early Eocene. With detailed biostratigraphic and chemostratigraphic analyses documenting the most complete record to date available for the PETM event in a shallow-water marine environment, I correlated chemostratigraphically for the first time the evolution of LF with the δ¹³C curves. This correlation demonstrated that no major turnover in the LF communities occurred synchronous with the PETM; thus the evolution of LF was mainly controlled by endogenous biotic forces. The study of Late Thanetian metric-sized microbialite-coral mounds which developed in the middle part of the ramp, documented the first Cenozoic occurrence of microbially-cemented mounds. The development of these mounds, with temporary dominance of microbial communities over corals, suggest environmentally-triggered "phase shifts" related to frequent fluctuations of nutrient/turbidity levels during recurrent wet phases which preceding the extreme greenhouse conditions of the PETM. The paleoecological study of the coral community in the microbialites-coral mounds, the study of corals from Early Eocene platform from SW France, and a critical, extensive literature research of Late Paleocene - Early Eocene coral occurrences from the Tethys, the Atlantic, the Caribbean realms suggested that these corals types, even if not forming extensive reefs, are common in the biofacies as small isolated colonies, piles of rubble or small patch-reefs. These corals might have developed 'alternative' life strategies to cope with harsh conditions (high/fluctuating nutrients/turbidity, extreme temperatures, perturbation of aragonite saturation state) during the greenhouse times of the early Paleogene, representing a good fossil analogue to modern corals thriving close to their thresholds for survival. These results demonstrate the complexity of the biological responses to extreme conditions, not only in terms of temperature but also nutrient supply, physical disturbance and their temporal variability and oscillating character.}, language = {en} } @phdthesis{ElSaadany2009, author = {El-Saadany, Mohamed Abdel Meged Marawan}, title = {Protective effect of dietary antioxidants and plant extracts on acute inflammation and hepatotoxicity in vitro}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-31585}, school = {Universit{\"a}t Potsdam}, year = {2009}, abstract = {Dietary antioxidants are believed to play an important role in the prevention and treatment of a variety of diseases associated with oxidative stress. Although there is a wide range of dietary antioxidants, the bulk of the research to date has been focused on the nutrient antioxidants vitamin C, E, and carotenoids. Certain relatively uncommon antioxidants such as lipoic acid (LA), and phenolic compounds such as (-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECG), and (-)-epigallocatechin gallate (EGCG), have not been extensively investigated although they may exert greater antioxidant potency than that of carotenoids and vitamins. Extracts from selected plants and plant byproducts may represent rich sources for one or more of such antioxidants and therefore exhibit higher effects than a single antioxidant due to the synergistic effects produced between such antioxidants. However, in the last decade a number of epidemiological, animal and in vitro studies have suggested a protective and therapeutic potency of these antioxidants in a broad range of diseases such as cancer, diabetes, atherosclerosis, cataract and acute and chronic neurological disorders. Inflammation, the response of the host toward any infection or injury, plays a central role in the development of many chronic diseases. Several evidences demonstrated the rise of different types of cancer from sites of inflammation. This suggests that active oxygen species and some cytokines generated in the inflamed tissues can cause injury to DNA and ultimately lead to carcinogenesis. Diethylnitrosamine (DEN) is one of the most important environmental carcinogens, present in a variety of foods, alcoholic beverages, tobacco smoke and it can be synthesized endogenously. In addition to the liver it can induce carcinogenesis in other organs like kidney, trachea, lung, esophagus, fore stomach, and nasal cavity. Several epidemiological and laboratory studies indicate that nitroso compounds including DEN may induce hyperplasia and chronic inflammation which is closely associated with the development of hepatocellular carcinoma. Despite increasing evidence on the potential of antioxidants in modulating the etiology of chronic diseases, little is known about their role in inflammation and acute phase response (APR). Therefore the aim of the present work was to study the protective effect of water and solvent extracts of eight plant and plant byproducts including green tea, artichoke, spinach, broccoli, onion and eggplant, orange and potato peels as well as eight antioxidants agents including EC, EGC, ECG, EGCG, ascorbic acid (AA), acetylcysteine (NAC), α-LA, and alpha-tocopherol (α-TOC) toward acute inflammation induced by interleukin-6 (IL-6) and hepatotoxicity induced by DEN in vitro. The negative acute phase proteins (APP), transthyretin (TTR) and retinol-binding protein (RBP) were used as inflammatory biomarkers analyzed by ELISA, whereas neutral red assay was used for evaluating the cytotoxicity. All experiments were performed in vitro using human hepatocarcinoma cell line (HepG2). Additionally the antioxidant activity was measured by TEAC and FRAP assays, phenolic content was measured by Folin-Ciocalteu and characterized by HPLC. Moreover, the microheterogeneity of TTR was detected using immunoprecipitation assay combined with SELDI-TOF MS. Results of present study showed that HepG2 cells provide a simple, sensitive in vitro system for studying the regulation of the negative APP, TTR and RBP under free and inflammatory condition. IL-6, a potent proinflammatory cytokine, in a concentration of 25 ng/ml was able to reduce TTR and RBP secretion by approximately 50-60\% after 24h of incubation. With exception of broccoli and water extract of onion which showed pro-inflammatory effects in this study, all other plant extracts, at specific concentrations, were able to elevate TTR secretion in normal condition and even under treatment of IL-6 where the effect was quite lower. Green tea followed by artichoke and potato peel exhibited the highest elevation in TTR concentration which reached 1.1 and 2.5 folds of control in presence and absences of IL-6 respectively. In general Plant extracts were ordered according their anti-inflammatory potency as following: in water extracts; green tea > artichoke > potato peel > orange peel > spinach > eggplant peel, where in solvent extracts; green tea > artichoke > potato peel > spinach > eggplant peel > onion > orange peel. The antiinflammatory effect of water extracts of green tea, artichoke and orange peel were significantly higher than their corresponding solvent extracts whereas water extracts of eggplant-, potato peels and spinach showed lower effect than their solvent extracts. On the other hand α-LA followed by EGCG and ECG exhibited the highest elevation in TTR concentration compared to other antioxidants. The relation between the anti-inflammatory potential and antioxidants activity and phenolic content for the investigated substances was generally weak. This may suggest the involvement of other mechanisms than antioxidants properties for the observed effect. TTR secreted by HepG2 cells has a molecular structure quite similar to the purified standard and serum TTR in which all the three main variants are contained including native, S-cystinylated and Sglutathionylated TTR. Interestingly, a variant with molecular mass of 13453.8 + 8.3 Da has been detected only in TTR secreted by HepG2. Among all investigated antioxidants and plant extracts, six substances were able to elevate the native preferable TTR variant. The potency of these substances can be ordered as following α-LA > NAC > onion > AA > EGCG > green tea. A weak correlation between elevation on TTR and shifting to the native form was observed. Similar weak correlation has also been observed between antioxidants activity and elevation in native TTR. Although DEN was able to induce cell death in a concentration dependent manner, it requires considerably higher concentrations for its effects especially after 24h. This may be attributed to a lack in cytochrome P450 enzymes produced by HepG2. At selected concentrations some antioxidants and plant extracts significantly attenuate DEN cytotoxicity as following: spinach > α-LA > artichoke > orange peel > eggplant peel > α-TOC > onion > AA. Contrary all other substances especially green tea, broccoli, potato peel, and ECG stimulate DEN toxicity. In conclusion, this study demonstrated that selected antioxidants and plant extracts may attenuate the inflammatory process, not only by their antioxidants potency but also by other mechanisms which remain unclear. They may also play a vital role on stabilizing the tetramic structure of TTR and thereby prevent amyloidosis diseases. Lipoic acid represents in this study unique function against inflammation and hepatotoxicity. Despite the protective effect demonstrated by investigated substances, attention should also be given to the pro-oxidant and potential cytotoxic effects produced at higher concentrations.}, language = {en} } @article{ViknerEngels2006, author = {Vikner, Sten and Engels, Eva}, title = {An optimality-theoretic analysis of scandinavian object shift and remnant VP-topicalisation}, series = {Linguistics in Potsdam}, journal = {Linguistics in Potsdam}, number = {25}, issn = {1616-7392}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32359}, pages = {195 -- 231}, year = {2006}, abstract = {Holmberg (1997, 1999) assumes that Holmberg's generalisation (HG) is derivational, prohibiting Object Shift (OS) across an intervening non-adverbial element at any point in the derivation. Counterexamples to this hypothesis are given in Fox \& Pesetsky (2005) which show that remnant VP-topicalisations are possible in Scandinavian as long as the VP-internal order relations are maintained. Extending the empirical basis concerning remnant VP-topicalisations, we argue that HG and the restrictions on object stranding result from the same, more general condition on order preservation. Considering this condition to be violable and to interact with various constraints on movement in an Optimality-theoretic fashion, we suggest an account for various asymmetries in the interaction between remnant VP-topicalisations and both OS and other movement operations (especially subject raising) as to their order preserving characteristics and stranding abilities.}, language = {en} } @article{Broekhuis2006, author = {Broekhuis, Hans}, title = {Derivations (MP) and evaluations (OT)}, series = {Linguistics in Potsdam}, journal = {Linguistics in Potsdam}, number = {25}, issn = {1616-7392}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32347}, pages = {137 -- 193}, year = {2006}, abstract = {The main claim of this paper is that the minimalist framework and optimality theory adopt more or less the same architecture of grammar: both assume that a generator defines a set S of potentially well-formed expressions that can be generated on the basis of a given input, and that there is an evaluator that selects the expressions from S that are actually grammatical in a given language L. The paper therefore proposes a model of grammar in which the strengths of the two frameworks are combined: more specifically, it is argued that the computational system of human language CHL from MP creates a set S of potentially well-formed expressions, and that these are subsequently evaluated in an optimality theoretic fashion.}, language = {en} } @article{Vogel2006, author = {Vogel, Ralf}, title = {The simple generator}, series = {Linguistics in Potsdam}, journal = {Linguistics in Potsdam}, number = {25}, issn = {1616-7392}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32338}, pages = {99 -- 136}, year = {2006}, abstract = {I argue that the shift of explanatory burden from the generator to the evaluator in OT syntax - together with the difficulties that arise when we try to formulate a working theory of the interfaces of syntax - leads to a number of assumptions about syntactic structures in OT which are quite different from those typical of minimalist syntax: formal features, as driving forces behind syntactic movement, are useless, and derivational and representational economy are problematic for both empirical and conceptual reasons. The notion of markedness, central in Optimality Theory, is not fully compatible with the idea of synactic economy. Even more so, seemingly obvious cases of blocking by structural economy do not seem to result from grammar proper, but reflect (economical) aspects of language use.}, language = {en} } @article{SamekLudovici2006, author = {Samek-Ludovici, Vieri}, title = {Optimality theory and the minimalist program}, series = {Linguistics in Potsdam}, journal = {Linguistics in Potsdam}, number = {25}, issn = {1616-7392}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32328}, pages = {77 -- 97}, year = {2006}, abstract = {Content: 1 Introduction 2 Crosslinguistic Variation 3 Constraint Conflict 3.1 Conflict between Prosody and Syntax 3.2 Conflict between Economy Principles 4 OT and Minimalism}, language = {en} } @article{Soschen2006, author = {Soschen, Alona}, title = {Natural law}, series = {Linguistics in Potsdam}, journal = {Linguistics in Potsdam}, number = {25}, issn = {1616-7392}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32316}, pages = {43 -- 76}, year = {2006}, abstract = {This work concentrates on the requirements of the computational system of HL, by developing the idea that Natural Law applies to universal syntactic principles. The systems of efficient growth are for the continuation of motion and maximal distance between the elements. The condition of maximization accounts for the properties of syntactic trees - binary branching, labeling, and the EPP. NL justifies the basic principle of organization in Merge: it provides a functional explanation of phase formation and thematic domains. In Optimality Theory, it accounts for the selection of a particular word order in languages. A comprehensive and definitive understanding of the principles underlying MP will eventually lead to a more advanced design of OT.}, language = {en} }