@misc{OPUS4-64186,
  title     = {forum:logop{\"a}die 29.2015, 1},
  series = {Forum Logop{\"a}die : Zeitschrift des Deutschen Bundesverbandes f{\"u}r Logop{\"a}die e.V, dbl},
  volume    = {29},
  journal   = {Forum Logop{\"a}die : Zeitschrift des Deutschen Bundesverbandes f{\"u}r Logop{\"a}die e.V, dbl},
  number    = {1},
  publisher = {Schulz-Kirchner},
  address   = {Idstein},
  organization    = {Deutscher Bundesverband f{\"u}r Logop{\"a}die e.V.},
  issn      = {0932-0547},
  pages     = {82},
  year      = {2015},
  language  = {de}
}
@misc{OPUS4-64184,
  title     = {forum:logop{\"a}die 29.2015, 2},
  series = {Forum Logop{\"a}die : Zeitschrift des Deutschen Bundesverbandes f{\"u}r Logop{\"a}die e.V, dbl},
  volume    = {29},
  journal   = {Forum Logop{\"a}die : Zeitschrift des Deutschen Bundesverbandes f{\"u}r Logop{\"a}die e.V, dbl},
  number    = {2},
  publisher = {Schulz-Kirchner},
  address   = {Idstein},
  organization    = {Deutscher Bundesverband f{\"u}r Logop{\"a}die e.V.},
  pages     = {79},
  year      = {2015},
  language  = {de}
}
@misc{OPUS4-64183,
  title     = {forum:logop{\"a}die 29.2015, 3},
  series = {Forum Logop{\"a}die : Zeitschrift des Deutschen Bundesverbandes f{\"u}r Logop{\"a}die e.V, dbl},
  volume    = {29},
  journal   = {Forum Logop{\"a}die : Zeitschrift des Deutschen Bundesverbandes f{\"u}r Logop{\"a}die e.V, dbl},
  number    = {3},
  publisher = {Schulz-Kirchner},
  address   = {Idstein},
  organization    = {Deutscher Bundesverband f{\"u}r Logop{\"a}die e.V.},
  issn      = {0932-0547},
  pages     = {70},
  year      = {2015},
  language  = {de}
}
@misc{OPUS4-64163,
  title     = {forum:logop{\"a}die 29.2015, 4},
  series = {Forum Logop{\"a}die : Zeitschrift des Deutschen Bundesverbandes f{\"u}r Logop{\"a}die e.V, dbl},
  volume    = {29},
  journal   = {Forum Logop{\"a}die : Zeitschrift des Deutschen Bundesverbandes f{\"u}r Logop{\"a}die e.V, dbl},
  number    = {4},
  publisher = {Schulz-Kirchner},
  address   = {Idstein},
  organization    = {Deutscher Bundesverband f{\"u}r Logop{\"a}die e.V.},
  issn      = {0932-0547},
  pages     = {78},
  year      = {2015},
  language  = {de}
}
@misc{OPUS4-64161,
  title     = {forum:logop{\"a}die 29.2015, 5},
  series = {Forum Logop{\"a}die : Zeitschrift des Deutschen Bundesverbandes f{\"u}r Logop{\"a}die e.V, dbl},
  volume    = {29},
  journal   = {Forum Logop{\"a}die : Zeitschrift des Deutschen Bundesverbandes f{\"u}r Logop{\"a}die e.V, dbl},
  number    = {5},
  publisher = {Schulz-Kirchner},
  address   = {Idstein},
  organization    = {Deutscher Bundesverband f{\"u}r Logop{\"a}die e.V.},
  issn      = {0932-0547},
  pages     = {78},
  year      = {2015},
  language  = {de}
}
@misc{OPUS4-64158,
  title     = {forum:logop{\"a}die 29.2015, 6},
  series = {Forum Logop{\"a}die : Zeitschrift des Deutschen Bundesverbandes f{\"u}r Logop{\"a}die e.V, dbl},
  volume    = {29},
  journal   = {Forum Logop{\"a}die : Zeitschrift des Deutschen Bundesverbandes f{\"u}r Logop{\"a}die e.V, dbl},
  number    = {6},
  publisher = {Schulz-Kirchner},
  address   = {Idstein},
  organization    = {Deutscher Bundesverband f{\"u}r Logop{\"a}die e.V.},
  issn      = {0932-0547},
  pages     = {66},
  year      = {2015},
  language  = {de}
}
@misc{JonesGonzalezFortesConnelletal.2015,
  author    = {Jones, Eppie R. and Gonz{\´a}lez-Fortes, Gloria M. and Connell, Sarah and Siska, Veronika and Eriksson, Anders and Martiniano, Rui and McLaughlin, Russell L. and Llorente, Marcos Gallego and Cassidy, Lara M. and Gamba, Cristina and Meshveliani, Tengiz and Bar-Yosef, Ofer and M{\"u}ller, Werner and Belfer-Cohen, Anna and Matskevich, Zinovi and Jakeli, Nino and Higham, Thomas F. G. and Currat, Mathias and Lordkipanidze, David and Hofreiter, Michael and Manica, Andrea and Pinhasi, Ron and Bradley, Daniel G.},
  title     = {Upper Palaeolithic genomes reveal deep roots of modern Eurasians},
  series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {1334},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-43931},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-439317},
  pages     = {8},
  year      = {2015},
  abstract  = {We extend the scope of European palaeogenomics by sequencing the genomes of Late Upper Palaeolithic (13,300 years old, 1.4-fold coverage) and Mesolithic (9,700 years old, 15.4-fold) males from western Georgia in the Caucasus and a Late Upper Palaeolithic (13,700 years old, 9.5-fold) male from Switzerland. While we detect Late Palaeolithic-Mesolithic genomic continuity in both regions, we find that Caucasus hunter-gatherers (CHG) belong to a distinct ancient clade that split from western hunter-gatherers ∼45 kya, shortly after the expansion of anatomically modern humans into Europe and from the ancestors of Neolithic farmers ∼25 kya, around the Last Glacial Maximum. CHG genomes significantly contributed to the Yamnaya steppe herders who migrated into Europe ∼3,000 BC, supporting a formative Caucasus influence on this important Early Bronze age culture. CHG left their imprint on modern populations from the Caucasus and also central and south Asia possibly marking the arrival of Indo-Aryan languages.},
  language  = {en}
}
@misc{HortobagyiLesinskiGaebleretal.2015,
  author    = {Hortob{\´a}gyi, Tibor and Lesinski, Melanie and G{\"a}bler, Martijn and VanSwearingen, Jessie M. and Malatesta, Davide and Granacher, Urs},
  title     = {Effects of three types of exercise interventions on healthy old adults' gait speed},
  series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  journal   = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  issn      = {1866-8364},
  doi       = {10.25932/publishup-43115},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-431150},
  pages     = {17},
  year      = {2015},
  abstract  = {Background: Habitual walking speed predicts many clinical conditions later in life, but it declines with age. However, which particular exercise intervention can minimize the age-related gait speed loss is unclear. Purpose: Our objective was to determine the effects of strength, power, coordination, and multimodal exercise training on healthy old adults' habitual and fast gait speed. Methods: We performed a computerized systematic literature search in PubMed and Web of Knowledge from January 1984 up to December 2014. Search terms included 'Resistance training', 'power training', 'coordination training', 'multimodal training', and 'gait speed (outcome term). Inclusion criteria were articles available in full text, publication period over past 30 years, human species, journal articles, clinical trials, randomized controlled trials, English as publication language, and subject age C65 years. The methodological quality of all eligible intervention studies was assessed using the Physiotherapy Evidence Database (PEDro) scale. We computed weighted average standardized mean differences of the intervention-induced adaptations in gait speed using a random-effects model and tested for overall and individual intervention effects relative to no-exercise controls. Results: A total of 42 studies (mean PEDro score of 5.0 +/- 1.2) were included in the analyses (2495 healthy old adults; age 74.2 years [64.4-82.7]; body mass 69.9 +/- 4.9 kg, height 1.64 +/- 0.05 m, body mass index 26.4 +/- 1.9 kg/m(2), and gait speed 1.22 +/- 0.18 m/s). The search identified only one power training study, therefore the subsequent analyses focused only on the effects of resistance, coordination, and multimodal training on gait speed. The three types of intervention improved gait speed in the three experimental groups combined (n = 1297) by 0.10 m/s (+/- 0.12) or 8.4 \% (+/- 9.7), with a large effect size (ES) of 0.84. Resistance (24 studies; n = 613; 0.11 m/s; 9.3 \%; ES: 0.84), coordination (eight studies, n = 198; 0.09 m/s; 7.6 \%; ES: 0.76), and multimodal training (19 studies; n = 486; 0.09 m/s; 8.4 \%, ES: 0.86) increased gait speed statistically and similarly. Conclusions: Commonly used exercise interventions can functionally and clinically increase habitual and fast gait speed and help slow the loss of gait speed or delay its onset.},
  language  = {en}
}
@misc{HartmannHasenkampMayeretal.2015,
  author    = {Hartmann, Stefanie and Hasenkamp, Natascha and Mayer, Jens and Michaux, Johan and Morand, Serge and Mazzoni, Camila J. and Roca, Alfred L. and Greenwood, Alex D.},
  title     = {Endogenous murine leukemia retroviral variation across wild European and inbred strains of house mouse},
  series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {1329},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-43120},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-431200},
  pages     = {13},
  year      = {2015},
  abstract  = {Background: Endogenous murine leukemia retroviruses (MLVs) are high copy number proviral elements difficult to comprehensively characterize using standard low throughput sequencing approaches. However, high throughput approaches generate data that is challenging to process, interpret and present. Results: Next generation sequencing (NGS) data was generated for MLVs from two wild caught Mus musculus domesticus (from mainland France and Corsica) and for inbred laboratory mouse strains C3H, LP/J and SJL. Sequence reads were grouped using a novel sequence clustering approach as applied to retroviral sequences. A Markov cluster algorithm was employed, and the sequence reads were queried for matches to specific xenotropic (Xmv), polytropic (Pmv) and modified polytropic (Mpmv) viral reference sequences. Conclusions: Various MLV subtypes were more widespread than expected among the mice, which may be due to the higher coverage of NGS, or to the presence of similar sequence across many different proviral loci. The results did not correlate with variation in the major MLV receptor Xpr1, which can restrict exogenous MLVs, suggesting that endogenous MLV distribution may reflect gene flow more than past resistance to infection.},
  language  = {en}
}
@misc{OPUS4-58254,
  title     = {Open Access-Strategie der Universit{\"a}t Potsdam},
  doi       = {10.25932/publishup-58254},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-582541},
  pages     = {22},
  year      = {2015},
  abstract  = {Die Open Access-Strategie der Universit{\"a}t Potsdam verfolgt das Ziel, den offenen Zugang zu wissenschaftlichen Publikationen von Wissenschaftlern der Universit{\"a}t Potsdam nachhaltig zu f{\"o}rdern. Dazu werden sieben {\"u}bergeordnete strategische Ziele definiert, aus denen in einem zweiten Schritt konkrete Handlungsfelder abgeleitet werden. Die Strategie wurde am 16.12.2015 vom Senat der Universit{\"a}t Potsdam zustimmend zur Kenntnis genommen.},
  language  = {de}
}
@misc{Guenther2015,
  author    = {G{\"u}nther, Stephanie},
  title     = {Krisen und Krisenbearbeitung im Referendariat},
  series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  number    = {703},
  issn      = {1866-8364},
  doi       = {10.25932/publishup-43553},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-435532},
  pages     = {5},
  year      = {2015},
  language  = {de}
}
@misc{MardoukhiJeonMetzler2015,
  author    = {Mardoukhi, Yousof and Jeon, Jae-Hyung and Metzler, Ralf},
  title     = {Geometry controlled anomalous diffusion in random fractal geometries},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {980},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-47486},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-474864},
  pages     = {30134 -- 30147},
  year      = {2015},
  abstract  = {We investigate the ergodic properties of a random walker performing (anomalous) diffusion on a random fractal geometry. Extensive Monte Carlo simulations of the motion of tracer particles on an ensemble of realisations of percolation clusters are performed for a wide range of percolation densities. Single trajectories of the tracer motion are analysed to quantify the time averaged mean squared displacement (MSD) and to compare this with the ensemble averaged MSD of the particle motion. Other complementary physical observables associated with ergodicity are studied, as well. It turns out that the time averaged MSD of individual realisations exhibits non-vanishing fluctuations even in the limit of very long observation times as the percolation density approaches the critical value. This apparent non-ergodic behaviour concurs with the ergodic behaviour on the ensemble averaged level. We demonstrate how the non-vanishing fluctuations in single particle trajectories are analytically expressed in terms of the fractal dimension and the cluster size distribution of the random geometry, thus being of purely geometrical origin. Moreover, we reveal that the convergence scaling law to ergodicity, which is known to be inversely proportional to the observation time T for ergodic diffusion processes, follows a power-law ∼T-h with h < 1 due to the fractal structure of the accessible space. These results provide useful measures for differentiating the subdiffusion on random fractals from an otherwise closely related process, namely, fractional Brownian motion. Implications of our results on the analysis of single particle tracking experiments are provided.},
  language  = {en}
}
@misc{AlterMeyerPostetal.2015,
  author    = {Alter, S. Elizabeth and Meyer, Matthias and Post, Klaas and Czechowski, Paul and Gravlund, Peter and Gaines, Cork and Rosenbaum, Howard C. and Kaschner, Kristin and Turvey, Samuel T. and van der Plicht, Johannes and Shapiro, Beth and Hofreiter, Michael},
  title     = {Climate impacts on transocean dispersal and habitat in gray whales from the Pleistocene to 2100},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
  number    = {965},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-43892},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-438920},
  pages     = {1510 -- 1522},
  year      = {2015},
  abstract  = {Arctic animals face dramatic habitat alteration due to ongoing climate change. Understanding how such species have responded to past glacial cycles can help us forecast their response to today's changing climate. Gray whales are among those marine species likely to be strongly affected by Arctic climate change, but a thorough analysis of past climate impacts on this species has been complicated by lack of information about an extinct population in the Atlantic. While little is known about the history of Atlantic gray whales or their relationship to the extant Pacific population, the extirpation of the Atlantic population during historical times has been attributed to whaling. We used a combination of ancient and modern DNA, radiocarbon dating and predictive habitat modelling to better understand the distribution of gray whales during the Pleistocene and Holocene. Our results reveal that dispersal between the Pacific and Atlantic was climate dependent and occurred both during the Pleistocene prior to the last glacial period and the early Holocene immediately following the opening of the Bering Strait. Genetic diversity in the Atlantic declined over an extended interval that predates the period of intensive commercial whaling, indicating this decline may have been precipitated by Holocene climate or other ecological causes. These first genetic data for Atlantic gray whales, particularly when combined with predictive habitat models for the year 2100, suggest that two recent sightings of gray whales in the Atlantic may represent the beginning of the expansion of this species' habitat beyond its currently realized range.},
  language  = {en}
}
@misc{HofreiterPaijmansGoodchildetal.2015,
  author    = {Hofreiter, Michael and Paijmans, Johanna L. A. and Goodchild, Helen and Speller, Camilla F. and Barlow, Axel and Gonzalez-Fortes, Gloria M. and Thomas, Jessica A. and Ludwig, Arne and Collins, Matthew J.},
  title     = {The future of ancient DNA},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
  number    = {908},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-43881},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-438816},
  pages     = {284 -- 295},
  year      = {2015},
  abstract  = {Technological innovations such as next generation sequencing and DNA hybridisation enrichment have resulted in multi-fold increases in both the quantity of ancient DNA sequence data and the time depth for DNA retrieval. To date, over 30 ancient genomes have been sequenced, moving from 0.7x coverage (mammoth) in 2008 to more than 50x coverage (Neanderthal) in 2014. Studies of rapid evolutionary changes, such as the evolution and spread of pathogens and the genetic responses of hosts, or the genetics of domestication and climatic adaptation, are developing swiftly and the importance of palaeogenomics for investigating evolutionary processes during the last million years is likely to increase considerably. However, these new datasets require new methods of data processing and analysis, as well as conceptual changes in interpreting the results. In this review we highlight important areas of future technical and conceptual progress and discuss research topics in the rapidly growing field of palaeogenomics.},
  language  = {en}
}
@misc{DittmarSeyfriedKaeveretal.2015,
  author    = {Dittmar, Fanni and Seyfried, Salim and Kaever, Volkhard and Seifert, Roland},
  title     = {Zebrafish as model organism for cNMP research},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {902},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-43697},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-436978},
  pages     = {4},
  year      = {2015},
  language  = {en}
}
@misc{GranacherHortobagyi2015,
  author    = {Granacher, Urs and Hortob{\´a}gyi, Tibor},
  title     = {Exercise to improve mobility in healthy aging},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {897},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-43241},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-432419},
  pages     = {4},
  year      = {2015},
  language  = {en}
}
@misc{HortobagyiLesinskiFernandez‐del‐Olmoetal.2015,
  author    = {Hortob{\´a}gyi, Tibor and Lesinski, Melanie and Fernandez-del-Olmo, Miguel and Granacher, Urs},
  title     = {Small and inconsistent effects of whole body vibration on athletic performance},
  series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  number    = {627},
  issn      = {1866-8364},
  doi       = {10.25932/publishup-43199},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-431993},
  pages     = {23},
  year      = {2015},
  abstract  = {Purpose We quantified the acute and chronic effects of whole body vibration on athletic performance or its proxy measures in competitive and/or elite athletes. Methods Systematic literature review and meta-analysis. Results Whole body vibration combined with exercise had an overall 0.3 \% acute effect on maximal voluntary leg force (-6.4 \%, effect size = -0.43, 1 study), leg power (4.7 \%, weighted mean effect size = 0.30, 6 studies), flexibility (4.6 \%, effect size = -0.12 to 0.22, 2 studies), and athletic performance (-1.9 \%, weighted mean effect size = 0.26, 6 studies) in 191 (103 male, 88 female) athletes representing eight sports (overall effect size = 0.28). Whole body vibration combined with exercise had an overall 10.2 \% chronic effect on maximal voluntary leg force (14.6 \%, weighted mean effect size = 0.44, 5 studies), leg power (10.7 \%, weighted mean effect size = 0.42, 9 studies), flexibility (16.5 \%, effect size = 0.57 to 0.61, 2 studies), and athletic performance (-1.2 \%, weighted mean effect size = 0.45, 5 studies) in 437 (169 male, 268 female) athletes (overall effect size = 0.44). Conclusions Whole body vibration has small and inconsistent acute and chronic effects on athletic performance in competitive and/or elite athletes. These findings lead to the hypothesis that neuromuscular adaptive processes following whole body vibration are not specific enough to enhance athletic performance. Thus, other types of exercise programs (e.g., resistance training) are recommended if the goal is to improve athletic performance.},
  language  = {en}
}
@misc{KleibrinkNiehavesPalopetal.2015,
  author    = {Kleibrink, Alexander and Niehaves, Bj{\"o}rn and Palop, Pau and S{\"o}rvik, Jens and Thapa, Basanta E. P.},
  title     = {Regional ICT innovation in the European Union},
  series = {Postprints der Universit{\"a}t Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe},
  number    = {124},
  issn      = {1867-5808},
  doi       = {10.25932/publishup-43160},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-431608},
  pages     = {320 -- 333},
  year      = {2015},
  abstract  = {In the current programming period, European Union (EU) regions and member states that want to use European Regional Development Funds (ERDF) are required to develop innovation strategies for smart specialization (RIS3) based on the idea of rational strategic management. In order to explore the relationship between strategic policy design and policy performance, this article maps regional strategies for information and communication technologies (ICT) and their effects in the period 2008-2012. Furthermore, it generates suggestions for relevant case studies. We first conduct a quantitative analysis of the effects of ICT strategies and ERDF expenditure on regional ICT performance in Western European regions. ICT is a relevant priority for many regions, and it reflects EU priorities fostering ICT activities through regional development funds. Second, we propose a framework to categorize EU regions in the context of ICT policy based on the expected distribution of regional ICT performance. Our analysis covers 97 regions in 9 EU member states, out of which 29 have had a dedicated ICT strategy. In line with ideas of rational strategic management, our working hypothesis states that regions with a dedicated strategy should display better performance. However, our findings suggest that having a dedicated ICT strategy has not had a clear effect on performance in terms of Internet and broadband access, while allocating dedicated ERDF and other expenditure to Internet infrastructure has had a positive effect. At first sight, this questions the effectiveness of rational strategic management. Yet, more research is needed to assess the quality of ICT strategies and their fit with broader innovation agendas. It is indeed the degree of embeddedness of ICT in the regional innovation ecosystem that is likely to condition the effect of strategies on performance. To this end, our mapping indicates interesting case studies, and we suggest additional factors to be taken into account in future analyses. New insights into strategy design and performance will also be important to inform the implementation of the new generation of innovation strategies for smart specialization.},
  language  = {en}
}
@misc{AcevedoReichCubasch2015,
  author    = {Acevedo, Walter and Reich, Sebastian and Cubasch, Ulrich},
  title     = {Towards the assimilation of tree-ring-width records using ensemble Kalman filtering techniques},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
  volume    = {46},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
  number    = {892},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-43636},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-436363},
  pages     = {1909 -- 1920},
  year      = {2015},
  abstract  = {This paper investigates the applicability of the Vaganov-Shashkin-Lite (VSL) forward model for tree-ring-width chronologies as observation operator within a proxy data assimilation (DA) setting. Based on the principle of limiting factors, VSL combines temperature and moisture time series in a nonlinear fashion to obtain simulated TRW chronologies. When used as observation operator, this modelling approach implies three compounding, challenging features: (1) time averaging, (2) "switching recording" of 2 variables and (3) bounded response windows leading to "thresholded response". We generate pseudo-TRW observations from a chaotic 2-scale dynamical system, used as a cartoon of the atmosphere-land system, and attempt to assimilate them via ensemble Kalman filtering techniques. Results within our simplified setting reveal that VSL's nonlinearities may lead to considerable loss of assimilation skill, as compared to the utilization of a time-averaged (TA) linear observation operator. In order to understand this undesired effect, we embed VSL's formulation into the framework of fuzzy logic (FL) theory, which thereby exposes multiple representations of the principle of limiting factors. DA experiments employing three alternative growth rate functions disclose a strong link between the lack of smoothness of the growth rate function and the loss of optimality in the estimate of the TA state. Accordingly, VSL's performance as observation operator can be enhanced by resorting to smoother FL representations of the principle of limiting factors. This finding fosters new interpretations of tree-ring-growth limitation processes.},
  language  = {en}
}
@misc{Daviter2015,
  author    = {Daviter, Falk},
  title     = {The political use of knowledge in the policy process},
  series = {Postprints der Universit{\"a}t Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe},
  number    = {123},
  issn      = {1867-5808},
  doi       = {10.25932/publishup-43548},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-435481},
  pages     = {491 -- 505},
  year      = {2015},
  abstract  = {The role of knowledge in the policy process remains a central theoretical puzzle in policy analysis and political science. This article argues that an important yet missing piece of this puzzle is the systematic exploration of the political use of policy knowledge. While much of the recent debate has focused on the question of how the substantive use of knowledge can improve the quality of policy choices, our understanding of the political use of knowledge and its effects in the policy process has remained deficient in key respects. A revised conceptualization of the political use of knowledge is introduced that emphasizes how conflicting knowledge can be used to contest given structures of policy authority. This allows the analysis to differentiate between knowledge creep and knowledge shifts as two distinct types of knowledge effects in the policy process. While knowledge creep is associated with incremental policy change within existing policy structures, knowledge shifts are linked to more fundamental policy change in situations when the structures of policy authority undergo some level of transformation. The article concludes by identifying characteristics of the administrative structure of policy systems or sectors that make knowledge shifts more or less likely.},
  language  = {en}
}
@misc{NowakRussoSchlapbachetal.2015,
  author    = {Nowak, Michael D. and Russo, Giancarlo and Schlapbach, Ralph and Huu, Cuong Nguyen and Lenhard, Michael and Conti, Elena},
  title     = {The draft genome of Primula veris yields insights into the molecular basis of heterostyly},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
  number    = {879},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-43508},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-435088},
  pages     = {19},
  year      = {2015},
  abstract  = {Background The flowering plant Primula veris is a common spring blooming perennial that is widely cultivated throughout Europe. This species is an established model system in the study of the genetics, evolution, and ecology of heterostylous floral polymorphisms. Despite the long history of research focused on this and related species, the continued development of this system has been restricted due the absence of genomic and transcriptomic resources. Results We present here a de novo draft genome assembly of P. veris covering 301.8 Mb, or approximately 63\% of the estimated 479.22 Mb genome, with an N50 contig size of 9.5 Kb, an N50 scaffold size of 164 Kb, and containing an estimated 19,507 genes. The results of a RADseq bulk segregant analysis allow for the confident identification of four genome scaffolds that are linked to the P. veris S-locus. RNAseq data from both P. veris and the closely related species P. vulgaris allow for the characterization of 113 candidate heterostyly genes that show significant floral morph-specific differential expression. One candidate gene of particular interest is a duplicated GLOBOSA homolog that may be unique to Primula (PveGLO2), and is completely silenced in L-morph flowers. Conclusions The P. veris genome represents the first genome assembled from a heterostylous species, and thus provides an immensely important resource for future studies focused on the evolution and genetic dissection of heterostyly. As the first genome assembled from the Primulaceae, the P. veris genome will also facilitate the expanded application of phylogenomic methods in this diverse family and the eudicots as a whole.},
  language  = {en}
}
@misc{BrownDonadiniNilssonetal.2015,
  author    = {Brown, Maxwell C. and Donadini, Fabio and Nilsson, Andreas and Panovska, Sanja and Frank, Ute and Korhonen, Kimmo and Schuberth, Maximilian and Korte, Monika and Constable, Catherine G.},
  title     = {GEOMAGIA50.v3},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
  number    = {875},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-43476},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-434768},
  pages     = {21},
  year      = {2015},
  abstract  = {Background: GEOMAGIA50.v3 for sediments is a comprehensive online database providing access to published paleomagnetic, rock magnetic, and chronological data obtained from lake and marine sediments deposited over the past 50 ka. Its objective is to catalogue data that will improve our understanding of changes in the geomagnetic field, physical environments, and climate. Findings: GEOMAGIA50.v3 for sediments builds upon the structure of the pre-existing GEOMAGIA50 database for magnetic data from archeological and volcanic materials. A strong emphasis has been placed on the storage of geochronological data, and it is the first magnetic archive that includes comprehensive radiocarbon age data from sediments. The database will be updated as new sediment data become available. Conclusions: The web-based interface for the sediment database is located at http://geomagia.gfz-potsdam.de/geomagiav3/SDquery.php. This paper is a companion to Brown et al. (Earth Planets Space doi:10.1186/s40623-015-0232-0,2015) and describes the data types, structure, and functionality of the sediment database.},
  language  = {en}
}
@misc{HermanussenSchefflerGrothetal.2015,
  author    = {Hermanussen, Michael and Scheffler, Christiane and Groth, Detlef and Aßmann, Christian},
  title     = {Height and skeletal morphology in relation to modern life style},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
  number    = {869},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-43481},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-434814},
  pages     = {7},
  year      = {2015},
  abstract  = {Height and skeletal morphology strongly relate to life style. Parallel to the decrease in physical activity and locomotion, modern people are slimmer in skeletal proportions. In German children and adolescents, elbow breadth and particularly relative pelvic breadth (50th centile of bicristal distance divided by body height) have significantly decreased in recent years. Even more evident than the changes in pelvic morphology are the rapid changes in body height in most modern countries since the end-19th and particularly since the mid-20th century. Modern Japanese mature earlier; the age at take-off (ATO, the age at which the adolescent growth spurt starts) decreases, and they are taller at all ages. Preece-Baines modelling of six national samples of Japanese children and adolescents, surveyed between 1955 and 2000, shows that this gain in height is largely an adolescent trend, whereas height at take-off (HTO) increased by less than 3 cm since 1955; adolescent growth (height gain between ATO and adult age) increased by 6 cm. The effect of globalization on the modern post-war Japanese society ("community effect in height") on adolescent growth is discussed.},
  language  = {en}
}
@misc{LiesenjohannLiesenjohannTrebatickaetal.2015,
  author    = {Liesenjohann, Thilo and Liesenjohann, Monique and Trebaticka, Lenka and Sundell, Janne and Haapakoski, Marko and Yl{\"o}nen, Hannu and Eccard, Jana},
  title     = {State-dependent foraging},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {857},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-43287},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-432878},
  pages     = {747 -- 754},
  year      = {2015},
  abstract  = {Parental care often produces a trade-off between meeting nutritional demands of offspring and the duties of offspring protection, especially in altricial species. Parents have to leave their young unattended for foraging trips, during which nestlings are exposed to predators. We investigated how rodent mothers of altricial young respond to risk of nest predation in their foraging decisions. We studied foraging behavior of lactating bank voles (Myodes glareolus) exposed to a nest predator, the common shrew (Sorex araneus). We conducted the experiment in summer (high resource provisioning for both species) and autumn (less food available) in 12 replicates with fully crossed factors "shrew presence" and "season." We monitored use of feeding stations near and far from the nest as measurement of foraging activity and strategic foraging behavior. Vole mothers adapted their strategies to shrew presence and optimized their foraging behavior according to seasonal constraints, resulting in an interaction of treatment and season. In summer, shrew presence reduced food intake from feeding stations, while it enhanced intake in autumn. Shrew presence decreased the number of visited feeding stations in autumn and concentrated mother's foraging efforts to fewer stations. Independent of shrew presence or season, mothers foraged more in patches further away from the nest than near the nest. Results indicate that females are not investing in nest guarding but try to avoid the accumulation of olfactory cues near the nest leading a predator to the young. Additionally, our study shows how foraging strategies and nest attendance are influenced by seasonal food provision.},
  language  = {en}
}
@misc{KnappLaluezaFoxHofreiter2015,
  author    = {Knapp, Michael and Lalueza-Fox, Carles and Hofreiter, Michael},
  title     = {Re-inventing ancient human DNA},
  series = {Postprints der Universit{\"a}t Potsdam Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam Mathematisch-Naturwissenschaftliche Reihe},
  number    = {853},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-43177},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-431775},
  pages     = {14},
  year      = {2015},
  abstract  = {For a long time, the analysis of ancient human DNA represented one of the most controversial disciplines in an already controversial field of research. Scepticism in this field was only matched by the long-lasting controversy over the authenticity of ancient pathogen DNA. This ambiguous view on ancient human DNA had a dichotomous root. On the one hand, the interest in ancient human DNA is great because such studies touch on the history and evolution of our own species. On the other hand, because these studies are dealing with samples from our own species, results are easily compromised by contamination of the experiments with modern human DNA, which is ubiquitous in the environment. Consequently, some of the most disputed studies published - apart maybe from early reports on million year old dinosaur or amber DNA - reported DNA analyses from human subfossil remains. However, the development of so-called next- or second-generation sequencing (SGS) in 2005 and the technological advances associated with it have generated new confidence in the genetic study of ancient human remains. The ability to sequence shorter DNA fragments than with PCR amplification coupled to traditional Sanger sequencing, along with very high sequencing throughput have both reduced the risk of sequencing modern contamination and provided tools to evaluate the authenticity of DNA sequence data. The field is now rapidly developing, providing unprecedented insights into the evolution of our own species and past human population dynamics as well as the evolution and history of human pathogens and epidemics. Here, we review how recent technological improvements have rapidly transformed ancient human DNA research from a highly controversial subject to a central component of modern anthropological research. We also discuss potential future directions of ancient human DNA research.},
  language  = {en}
}
@misc{HerbstFranzkeWickeetal.2015,
  author    = {Herbst, Uta and Franzke, Jochen and Wicke, Markus and Weber, Susann and Dobrigkeit, Philipp and Mikulcov{\´a}, Anna and Wanagas, Torsten and Sim, Chu-Won and Klosa, Sven and Geißler-Gr{\"u}nberg, Anke and Winter, Jean-Pierre and Koch, Helvi and Henrich, Lutz and K{\"o}nig, Julia and Stab, Uwe and Schmidt, Sina and Knuth, Alexander},
  title     = {Portal alumni},
  series = {Das Ehemaligen-Magazin der Universit{\"a}t Potsdam},
  journal   = {Das Ehemaligen-Magazin der Universit{\"a}t Potsdam},
  number    = {12},
  organization    = {Stabsstelle Studierendenmarketing/Alumniprogramm Im Auftrag der Pr{\"a}sidentin der Universit{\"a}t Potsdam},
  issn      = {1613-2343},
  doi       = {10.25932/publishup-44529},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-445297},
  pages     = {68},
  year      = {2015},
  abstract  = {Die Beliebtheit von Medienberufen ist ungebrochen. Das zeigt sich unter anderem an der Zahl der Studieninteressierten. So haben sich allein in diesem Jahr mehr als 1 500 junge Leute auf einen der 44 Pl{\"a}tze f{\"u}r den Studiengang Medienwissenschaft an der Universit{\"a}t Potsdam beworben. Nach ihrem erfolgreichen Abschluss allerdings konkurrieren die Absolventen am Arbeitsmarkt mit Tausenden Abg{\"a}ngern anderer Hochschulen aus Film-, Medien- und Kommunikationsstudieng{\"a}ngen. Das sind allein in der Region Berlin-Brandenburg j{\"a}hrlich etwa 1 500. Doch nach jahrzehntelangem Boom der Medienbranche hat sich der Arbeitsmarkt im vergangenen Jahrzehnt drastisch ver{\"a}ndert. Konjunkturkrise, Kursr{\"u}ckg{\"a}nge und r{\"u}ckl{\"a}ufige Werbeinvestitionen schw{\"a}chten die Medien deutlich. Es folgten daraus schlechte Gewinnergebnisse, Einsparungen und Personalreduzierung, insbesondere bei den Printmedien. Die Insolvenz der Frankfurter Rundschau oder die Einstellung der Financial Times Deutschland sind nur zwei eklatante Beispiele. Auf der anderen Seite boomt der dynamische Online-Markt aufgrund des ver{\"a}nderten Nutzerverhaltens insbesondere der jungen Generation, die ihre Informationen zunehmend aus Internet, Apps und sozialen Netzwerken gewinnen. Die Berufsaussichten f{\"u}r all Jene, die „Irgendwas mit Medien" studieren wollen sind zwar aufgrund des Arbeitsmarktes schwieriger geworden, sie sind aber dennoch vielf{\"a}ltig. Guter Journalismus wird weiterhin ben{\"o}tigt und auch {\"O}ffentlichkeitsarbeiter sind gefragt. Dar{\"u}ber hinaus stehen Absolveninspiriert von den Fernsehbildern, als Tausende Fl{\"u}chtlinge herzlich in M{\"u}nchen empfangen wurden, kam unserem Kollegen Eric Makswitat die Idee, sich auch auf lokaler Ebene f{\"u}r die hier ankommenden Fl{\"u}chtlinge zu engagieren. Der Doktorand in der Politikwissenschaft sammelt {\"u}ber das Internet B{\"u}cher f{\"u}r Fl{\"u}chtlinge und gibt sie dann direkt in den Fl{\"u}chtlingsunterk{\"u}nften ab. Eric Makswitat ist einer von Vielen, die derzeit einen wichtigen Beitrag zur Bew{\"a}ltigung der Herausforderungen des Fl{\"u}chtlingszustroms nach Deutschland leisten. Die engagierten Helfer sind „ein Beweis daf{\"u}r, wie weit die Selbstorganisationskr{\"a}fte der organisierten B{\"u}rgerschaft in unserer Zivilgesellschaft mittlerweile entwickelt sind", meint dazu der Verwaltungswissenschaftler Jochen Franzke. Unser Kollege Eric ist auch in anderer Hinsicht beispielgebend. Er ist einer von rund achtzig Prozent aller ehemaligen Studierenden, die nach dem Studienabschluss in der Region bleiben, wie eine k{\"u}rzlich an der Uni ver{\"o}ffentlichte Studie zum Verbleib unserer Absolventinnen und Absolventen ermittelt hat. Unsere Alumni steigen ein in Berufsfeldern der Politik, Wirtschaft und Gesellschaft, sie gr{\"u}nden Firmen und sie engagieren sich beruflich, privat oder gesellschaftlich. Viele davon in Potsdam. Wenn die Universit{\"a}t Potsdam im n{\"a}chsten Jahr ihr 25-j{\"a}hriges Jubil{\"a}um in und mit der Stadt Potsdam feiern wird und mit Stolz auf hervorragende Leistungen aus Lehre und Forschung verweist, dann ist dies nicht zuletzt den Absolventinnen und Absolventen zu verdanken, die als hochqualifizierte Fachkr{\"a}fte neueste wissenschaftliche Erkenntnisse in die Praxis {\"u}berf{\"u}hren. Portal alumni ist deshalb in diesem Jahr hier, zu Hause in Potsdam geblieben. Wir haben Absolventen der Universit{\"a}t Potsdam gesucht, die heute in unterschiedlichen beruflichen und gesellschaftlichen Kontexten in der Region aktiv sind und sich engagieren.},
  language  = {de}
}
@misc{MuehlenbruchKuxhausPencinaetal.2015,
  author    = {M{\"u}hlenbruch, Kristin and Kuxhaus, Olga and Pencina, Michael J. and Boeing, Heiner and Liero, Hannelore and Schulze, Matthias Bernd},
  title     = {A confidence ellipse for the Net Reclassification Improvement},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
  number    = {825},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-42737},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-427371},
  pages     = {299 -- 304},
  year      = {2015},
  abstract  = {The Net Reclassification Improvement (NRI) has become a popular metric for evaluating improvement in disease prediction models through the past years. The concept is relatively straightforward but usage and interpretation has been different across studies. While no thresholds exist for evaluating the degree of improvement, many studies have relied solely on the significance of the NRI estimate. However, recent studies recommend that statistical testing with the NRI should be avoided. We propose using confidence ellipses around the estimated values of event and non-event NRIs which might provide the best measure of variability around the point estimates. Our developments are illustrated using practical examples from EPIC-Potsdam study.},
  language  = {en}
}
@misc{KuhlmannBuergerEsseretal.2015,
  author    = {Kuhlmann, Sophie Merle and B{\"u}rger, Arne and Esser, G{\"u}nter and Hammerle, Florian},
  title     = {A mindfulness-based stress prevention training for medical students (MediMind)},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe 820},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe 820},
  number    = {820},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-42756},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-427568},
  pages     = {13},
  year      = {2015},
  abstract  = {Background: Medical training is very demanding and associated with a high prevalence of psychological distress. Compared to the general population, medical students are at a greater risk of developing a psychological disorder. Various attempts of stress management training in medical school have achieved positive results on minimizing psychological distress; however, there are often limitations. Therefore, the use of a rigorous scientific method is needed. The present study protocol describes a randomized controlled trial to examine the effectiveness of a specifically developed mindfulness-based stress prevention training for medical students that includes selected elements of cognitive behavioral strategies (MediMind). Methods/Design: This study protocol presents a prospective randomized controlled trial, involving four assessment time points: baseline, post-intervention, one-year follow-up and five-year follow-up. The aims include evaluating the effect on stress, coping, psychological morbidity and personality traits with validated measures. Participants are allocated randomly to one of three conditions: MediMind, Autogenic Training or control group. Eligible participants are medical or dental students in the second or eighth semester of a German university. They form a population of approximately 420 students in each academic term. A final total sample size of 126 (at five-year follow-up) is targeted. The trainings (MediMind and Autogenic Training) comprise five weekly sessions lasting 90 minutes each. MediMind will be offered to participants of the control group once the five-year follow-up is completed. The allotment is randomized with a stratified allocation ratio by course of studies, semester, and gender. After descriptive statistics have been evaluated, inferential statistical analysis will be carried out with a repeated measures ANOVA-design with interactions between time and group. Effect sizes will be calculated using partial η-square values. Discussion: Potential limitations of this study are voluntary participation and the risk of attrition, especially concerning participants that are allocated to the control group. Strengths are the study design, namely random allocation, follow-up assessment, the use of control groups and inclusion of participants at different stages of medical training with the possibility of differential analysis.},
  language  = {en}
}
@misc{RoethleinMiettinenIgnatova2015,
  author    = {Roethlein, Christoph and Miettinen, Markus S. and Ignatova, Zoya},
  title     = {A flexible approach to assess fluorescence decay functions in complex energy transfer systems},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe 819},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe 819},
  number    = {819},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-42755},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-427557},
  pages     = {12},
  year      = {2015},
  abstract  = {Background: Time-correlated Forster resonance energy transfer (FRET) probes molecular distances with greater accuracy than intensity-based calculation of FRET efficiency and provides a powerful tool to study biomolecular structure and dynamics. Moreover, time-correlated photon count measurements bear additional information on the variety of donor surroundings allowing more detailed differentiation between distinct structural geometries which are typically inaccessible to general fitting solutions. Results: Here we develop a new approach based on Monte Carlo simulations of time-correlated FRET events to estimate the time-correlated single photon counts (TCSPC) histograms in complex systems. This simulation solution assesses the full statistics of time-correlated photon counts and distance distributions of fluorescently labeled biomolecules. The simulations are consistent with the theoretical predictions of the dye behavior in FRET systems with defined dye distances and measurements of randomly distributed dye solutions. We validate the simulation results using a highly heterogeneous aggregation system and explore the conditions to use this tool in complex systems. Conclusion: This approach is powerful in distinguishing distance distributions in a wide variety of experimental setups, thus providing a versatile tool to accurately distinguish between different structural assemblies in highly complex systems.},
  language  = {en}
}
@misc{GorochowskiIgnatovaBovenbergetal.2015,
  author    = {Gorochowski, Thomas E. and Ignatova, Zoya and Bovenberg, Roel A. L. and Roubos, Johannes A.},
  title     = {Trade-offs between tRNA abundance and mRNA secondary structure support smoothing of translation elongation rate},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {816},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-44134},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-441340},
  pages     = {13},
  year      = {2015},
  abstract  = {Translation of protein from mRNA is a complex multi-step process that occurs at a non-uniform rate. Variability in ribosome speed along an mRNA enables refinement of the proteome and plays a critical role in protein biogenesis. Detailed single protein studies have found both tRNA abundance and mRNA secondary structure as key modulators of translation elongation rate, but recent genome-wide ribosome profiling experiments have not observed significant influence of either on translation efficiency. Here we provide evidence that this results from an inherent trade-off between these factors. We find codons pairing to high-abundance tRNAs are preferentially used in regions of high secondary structure content, while codons read by significantly less abundant tRNAs are located in lowly structured regions. By considering long stretches of high and low mRNA secondary structure in Saccharomyces cerevisiae and Escherichia coli and comparing them to randomized-gene models and experimental expression data, we were able to distinguish clear selective pressures and increased protein expression for specific codon choices. The trade-off between secondary structure and tRNA-concentration based codon choice allows for compensation of their independent effects on translation, helping to smooth overall translational speed and reducing the chance of potentially detrimental points of excessively slow or fast ribosome movement.},
  language  = {en}
}
@misc{KimminichJaegerHornConradetal.2015,
  author    = {Kimminich, Eva and J{\"a}ger, Heidi and Horn-Conrad, Antje and Scholz, Jana and Zimmermann, Matthias and Kampe, Heike},
  title     = {Portal Wissen = Signs},
  number    = {02/2015},
  organization    = {University of Potsdam, Press and Public Relations Department},
  issn      = {2198-9974},
  doi       = {10.25932/publishup-44155},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-441553},
  pages     = {54},
  year      = {2015},
  abstract  = {Signs take a variety of forms. We use or encounter them every day in various areas. They represent perceptions and ideas: A letter represents a sound, a word or picture stands for an idea, a note for a sound, a chemical formula for a substance, a boundary stone for a territorial claim, a building for an ideology, a gesture for a cue or an assessment. On the one hand, we open up the world to ourselves by using signs; we acquire it, ensconce ourselves in it, and we punctuate it to represent ourselves in it. On the other, this reference to the world and ourselves becomes visible in our sign systems. As manifestations of a certain way of interacting with nature, the environment, and fellow human beings, they provide information about the social order or ethnic distinctions of a certain society or epoch as well as about how it perceives the world and humanity. As a man-made network of meanings, sign systems can be changed and, in doing so, change how we perceive the world and humanity. Linguistically, this may, for example, be done by using an evaluative prefix: human - inhuman, sense - nonsense, matter - anti-matter or by hierarchizing terms, as in upper class and lower class. The consequences of such labeling, therefore, may decide on the raison d'{\^e}tre of the signified within an aspect of reality and the nature of this existence. Since ancient times we have reflected on signs, at first mainly in philosophy. Each era has created theories of signs as a means of approaching its essence. Nowadays semiotics is especially concerned with them. While linguistics focuses on linguistic signs, semiotics deals with all types of signs and the interaction of components and processes involved in their communication. Semiotics has developed models, methods, and concepts. Semiosis and semiosphere, for example, are concepts that illuminate the processing of signs, i.e. the construction of meaning and the interaction of different sign systems. A sign is not limited to a monolithic meaning but is culturally contingent and marked by the socioeconomic conditions of the individual decoding it. Sociopolitical and sociocultural developments therefore affect the processing of signs. Dealing with signs and sign systems, their circulation, and reciprocal play with shapes and interpretive possibilities is therefore an urgent and trailblazing task in light of sociocultural communication processes in our increasingly heterogeneous society to optimize communication and promote intercultural understanding as well as to recognize, use, and bolster social trends. The articles in this magazine illustrate the many ways academia is involved in researching, interpreting, and explaining signs. Social scientists at the University of Potsdam are examining whether statistics about petitions made by GDR citizens can be interpreted retrospectively as a premonitory sign of the peaceful revolution of 1989. Colleagues at the Institute of Romance Studies are analyzing what Alexander von Humboldt's American travel diaries signalize, and young researchers in the Research Training Group on "Wicked Problems, Contested Administrations" are examining challenges that seem to raise question marks for administrations. A project promoting sustainable consumption hopes to prove that academia can contribute to setting an example. An initiative of historians supporting Brandenburg cities in disseminating the history of the Reformation shows that the gap between academia and signs and wonder is not unbridgeable. I wish you an inspiring read! Prof. Dr. Eva Kimminich Professor of Romance Cultural Studies},
  language  = {en}
}
@misc{MuellerRoeberZimmermannEckardtetal.2015,
  author    = {M{\"u}ller-R{\"o}ber, Bernd and Zimmermann, Matthias and Eckardt, Barbara and J{\"a}ger, Heidi and Kampe, Heike and Horn-Conrad, Antje and J{\"a}ger, Sophie},
  title     = {Portal Wissen = Paths},
  number    = {01/2015},
  organization    = {University of Potsdam, Press and Public Relations Department},
  issn      = {2198-9974},
  doi       = {10.25932/publishup-44150},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-441506},
  pages     = {55},
  year      = {2015},
  abstract  = {How traits are inherited from one generation to the next, how mutations change genetic information and consequently contribute to the development of new characteristics and emergence of new species - all these are exciting biological questions. Over millions of years, genetic differentiation has brought about an incredible diversity of species. Evolution has followed many different paths. It has led to an awesome natural biodiversity - to organisms that have adapted to very different environments and are sometimes oddly shaped or behave strangely. Humanmade biodiversity is stunning, too. Just think of the 10,000 rose varieties whose beauty delights, or the myriad wheat, barley, and corn variations; plants that had all once been plain grasses feed us today. We humans create our own biodiversity unknown to nature. And it is serving us well. Thanks to genome research we are now able to read the complete genetic information of organisms within a few hours or days. It takes much longer, however, to functionally map the many genomic sequences. Researchers achieve this through various methods: Activating or deactivating genes systematically, modifying their code, and exchanging genetic information between organisms have become standard procedures worldwide. The path to knowledge is often intricate, though. Elaborate experimental approaches are often necessary to gain insight into biological processes. Methods of genomic research enable us to investigate not only what is "out there" in nature, but also to ask, "How does a living organism, like a moss, react when sent to the International Space Station (ISS)? Can we gain knowledge about the adaptation strategies of living beings in harsh environmental conditions or even for colonizing the Moon or Mars?" Can we use synthetic biology to precisely alter microorganisms, planned on a drawing board so to speak, to create new options for treating diseases or for making innovative biology-based products? The answer to both questions is a resounding Yes! (Although moving to other planets is not on our present agenda.) Human land use determines biodiversity. On the other hand, organisms influence the formation of landscapes and, sooner or later, the composition of our atmosphere. This also leads to exciting scientific questions. Researchers have to strike new paths to reach new conclusions. Paths often cross other paths. A few years ago it was still unforeseeable that ecological research would substantially benefit from fast DNA sequencing methods. Genome researchers could hardly assume that the same techniques would lead to new possibilities for examining the highly complex cellular regulation and optimizing biotechnological processes. You will find examples of the multi-faceted research in biology as well as other very interesting articles in the latest edition of Portal Wissen. I wish you an enjoyable read! Prof. Dr. Bernd M{\"u}ller-R{\"o}ber Professor of Molecular Biology},
  language  = {en}
}
@misc{JaegerZimmermannKampeetal.2015,
  author    = {J{\"a}ger, Heidi and Zimmermann, Matthias and Kampe, Heike and G{\"o}rlich, Petra},
  title     = {Portal Wissen = Zeichen},
  number    = {02/2015},
  organization    = {Universit{\"a}t Potsdam, Referat f{\"u}r Presse- und {\"O}ffentlichkeitsarbeit},
  issn      = {2194-4237},
  doi       = {10.25932/publishup-44086},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-440864},
  pages     = {98},
  year      = {2015},
  abstract  = {Zeichen haben vielf{\"a}ltige Formen. Wir nutzen sie oder begegnen ihnen tagt{\"a}glich in verschiedenen Bereichen. Sie sind Stellvertreter f{\"u}r Wahrnehmungen und Vorstellungen: Ein Buchstabe steht f{\"u}r einen Laut, ein Wort oder Bild f{\"u}r eine Vorstellung, eine Note f{\"u}r einen Ton, eine chemische Formel f{\"u}r einen Stoff, ein Grenzstein f{\"u}r einen Gebietsanspruch, ein Bauwerk f{\"u}r eine Ideologie, eine Geste f{\"u}r einen Hinweis oder eine Bewertung usw. Einerseits erschließen wir uns mit Zeichen die Welt, eignen sie uns an, richten uns in ihr ein und stellen uns in ihr mittels Zeichensetzung dar. Anderseits wird diese Bezugnahme auf Welt und uns selbst durch unsere Zeichensysteme sichtbar. Als Ausdruck eines spezifischen Umgangs mit Natur, Umwelt und Mitmensch geben sie Auskunft {\"u}ber Welt- und Menschenbilder einer Gesellschaft oder Epoche, {\"u}ber ihre sozialen Ordnungen oder ethnischen Abgrenzungen. Als ein vom Menschen geschaffenes Netzwerk von Bedeutungen k{\"o}nnen Zeichensysteme ver{\"a}ndert werden und mit ihnen auch Welt- und Menschenbilder. Auf sprachlicher Ebene kann dies beispielsweise durch eine wertende Vorsilbe geschehen: Kraut - Unkraut, Mensch - Unmensch, Sinn - Unsinn, oder durch hierarchisierende Begriffe wie Ober- und Unterschicht. Die Konsequenzen solcher Etikettierungen entscheiden also unter Umst{\"a}nden {\"u}ber die Daseinsberechtigung des Bezeichneten innerhalb eines Wirklichkeitsausschnitts und {\"u}ber die Art dieses Daseins. {\"U}ber Zeichen wird bereits seit der Antike nachgedacht, zun{\"a}chst vor allem in der Philosophie. Jede Epoche hat ihre Theorien von Zeichen hervorgebracht, um sich ihrem Wesen zu n{\"a}hern. Heute befasst sich insbesondere die Semiotik mit ihnen. W{\"a}hrend sich die Linguistik auf sprachliche Zeichen konzentriert, widmet sich die Semiotik allen Zeichenarten und dem Zusammenspiel der Komponenten und Prozesse, die an ihrer Vermittlung beteiligt sind. Sie hat daf{\"u}r Modelle, Methoden und Konzepte entwickelt. Mit den Konzepten der Semiose sowie der Semiosph{\"a}re beispielsweise lassen sich der Prozess der Zeichenverarbeitung, d.h. der Sinnkonstruktion, bzw. das Zusammenwirken verschiedener Zeichensysteme beleuchten. Ein eindeutiger Sinn haftet einem Zeichen nicht an, er wird kulturell und durch die jeweiligen sozi{\"o}konomischen Rahmenbedingungen des entschl{\"u}sselnden Individuums mitgepr{\"a}gt. Gesellschaftspolitische und soziokulturelle Entwicklungen wirken sich daher auf die Zeichenverarbeitung aus. Sich mit Zeichen und Zeichensystemen zu befassen, mit ihrer Zirkulation und dem dabei zu beobachtenden wechselseitigen Spiel mit Formen und Deutungsm{\"o}glichkeiten, ist daher im Hinblick auf soziokulturelle Verst{\"a}ndigungsprozesse unserer zunehmend heterogenen Gesellschaft eine dringliche und richtungsweisende Aufgabe, um Kommunikation zu optimieren und interkulturelles Verst{\"a}ndnis zu bef{\"o}rdern, gesellschaftliche Entwicklungen zu erkennen, zu nutzen oder aufzufangen. Die Beitr{\"a}ge in diesem Heft zeigen, auf welch vielf{\"a}ltige Weise Wissenschaft mit Zeichen, ihrer Erforschung, Deutung und Erkl{\"a}rung befasst ist. So besch{\"a}ftigen sich Potsdamer Sozialwissenschaftler damit, ob Eingabenstatistiken von DDR-B{\"u}rgern r{\"u}ckblickend als Vorzeichen der friedlichen Revolution von 1989 gelesen werden k{\"o}nnen. Kollegen vom Institut f{\"u}r Romanistik wiederum untersuchen, was die amerikanischen Reisetageb{\"u}cher Alexander von Humboldts auszeichnet, und die Nachwuchsforscher des Graduiertenkollegs „Wicked Problems, Contested Administrations" nehmen gezielt Probleme in den Blick, bei denen Verwaltungen vor {\"u}bergroßen Fragezeichen zu stehen scheinen. Dass Wissenschaft dazu beitragen kann, Zeichen zu setzen, will ein Projekt zur F{\"o}rderung nachhaltigen Konsums beweisen. Eine Initiative von Historikern, die brandenburgische St{\"a}dte bei der Vermittlung der Geschichte der Reformation unterst{\"u}tzen zeigt, dass zwischen Wissenschaft auf der einen und Zeichen und Wundern auf der anderen Seite keine un{\"u}berbr{\"u}ckbare Kluft besteht. Ich w{\"u}nsche Ihnen eine anregende Lekt{\"u}re! Prof. Dr. Eva Kimminich Professorin f{\"u}r Kulturen Romanischer L{\"a}nder},
  language  = {de}
}
@misc{ZimmermannEckardtHornConradetal.2015,
  author    = {Zimmermann, Matthias and Eckardt, Barbara and Horn-Conrad, Antje and J{\"a}ger, Heidi and Kampe, Heike and Scholz, Jana and G{\"o}rlich, Petra and S{\"u}tterlin, Sabine and J{\"a}ger, Sophie and Scherbaum, Frank},
  title     = {Portal Wissen = Wege},
  number    = {01/2015},
  organization    = {Universit{\"a}t Potsdam, Referat f{\"u}r Presse- und {\"O}ffentlichkeitsarbeit},
  issn      = {2194-4237},
  doi       = {10.25932/publishup-44085},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-440851},
  pages     = {99},
  year      = {2015},
  abstract  = {Wie Merkmale von Generation zu Generation weitervererbt werden, wie sich die Erbinformation dabei durch Mutationen ver{\"a}ndert und somit zur Auspr{\"a}gung neuer Eigenschaften und der Entstehung neuer Arten beitr{\"a}gt, sind spannende Fragen der Biologie. Genetische Differenzierung f{\"u}hrte im Laufe von Jahrmillionen zur Ausbildung einer schier unglaublichen Artenvielfalt. Die Evolution hat viele Wege beschritten. Sie hat zu großartiger nat{\"u}rlicher Biodiversit{\"a}t gef{\"u}hrt - zu Organismen, die an sehr unterschiedliche Umwelten angepasst sind und zum Teil eine ulkige Gestalt haben oder ein merkw{\"u}rdiges Verhalten zeigen. Aber auch die von Menschenhand gemachte Biodiversit{\"a}t ist {\"u}berw{\"a}ltigend - man denke nur an die 10.000 verschiedenen Rosensorten, die uns entz{\"u}cken, oder die Myriaden unterschiedlicher Weizen-, Gerste- oder Maisvarianten; Pflanzen, die allesamt fr{\"u}her einmal einfache Gr{\"a}ser waren, uns heute aber ern{\"a}hren. Wir Menschen schaffen eine eigene Biodiversit{\"a}t, eine, die die Natur selbst nicht kennt. Und wir „fahren" gut damit. Dank der Genomforschung k{\"o}nnen wir heute die gesamte Erbinformation von Organismen in wenigen Stunden bis Tagen aus- lesen. Sehr viel l{\"a}nger dauert es aber, die zahlreichen Abschnitte eines Genoms funktionell zu kartieren. Die Wissenschaftler bedienen sich dazu vielf{\"a}ltiger Methoden: Dabei geh{\"o}rt es heute weltweit zum Standardrepertoire, Gene gezielt zu inaktivieren oder zu aktivieren, ihren Code zu modifizieren oder Erbinformationen zwischen Organismen auszutauschen. Dennoch sind die Wege, die zur Erkenntnis f{\"u}hren, oft verschlungen. Nicht selten m{\"u}ssen ausgekl{\"u}gelte experimentelle Ans{\"a}tze gew{\"a}hlt werden, um neue Einsichten in biologische Prozesse zu gewinnen. Mit den Methoden der Genomforschung k{\"o}nnen wir nicht nur das erkunden, was sich in der Natur „da draußen" findet. Wir k{\"o}nnen auch fragen: „Wie verh{\"a}lt sich ein Lebewesen, beispielsweise ein Moos, eigentlich, wenn wir es zur International Space Station (ISS) schicken? Und k{\"o}nnen wir daraus Kenntnisse gewinnen {\"u}ber die Anpassungsstrategien von Lebewesen an harsche Umweltbedingungen oder gar f{\"u}r eine sp{\"a}tere Besiedlung des Mondes oder des Mars´?" Oder k{\"o}nnen wir mithilfe der synthetischen Biologie Mikroorganismen pr{\"a}zise, quasi am Reißbrett geplant, so ver{\"a}ndern, dass neue Optionen f{\"u}r die Behandlung von Krankheiten und f{\"u}r die Herstellung innovativer biobasierter Produkte entstehen? Die Antwort auf beide Fragen lautet eindeutig: Ja! (Wenngleich ein Umzug auf andere Planeten derzeit nat{\"u}rlich nicht vornan steht.). Landnutzung durch den Menschen bestimmt die Biodiversit{\"a}t. Andererseits tragen Organismen zur landschaftlichen Formenbildung bei und beeinflussen {\"u}ber kurz oder lang die Zusammensetzung unserer Atmosph{\"a}re. Auch hier gibt es spannende Fragen, mit denen sich die Forschung besch{\"a}ftigt. Um neue Erkenntnisse zu gewinnen, m{\"u}ssen Forscher immer wieder neue Wege einschlagen. Oft kreuzen sich auch Pfade. So war es beispielsweise vor wenigen Jahren noch kaum absehbar, wir stark die {\"o}kologische Forschung beispielsweise von den schnellen DNA-Sequenziermethoden profitieren w{\"u}rde, und die Genomforscher unter uns konnten kaum erahnen, wie die gleichen Techniken uns neue M{\"o}glichkeiten an die Hand geben sollten, die hochkomplexe Regulation in Zellen zu untersuchen und f{\"u}r die Optimierung biotechnologischer Prozesse zu nutzen. Beispiele aus den vielf{\"a}ltigen Facetten der biologischen Forschung finden Sie - neben anderen interessanten Beitr{\"a}gen - in der aktuellen Ausgabe von „Portal Wissen". Ich w{\"u}nsche Ihnen eine anregende Lekt{\"u}re! Prof. Dr. Bernd M{\"u}ller-R{\"o}ber Professor f{\"u}r Molekularbiologie},
  language  = {de}
}
@misc{GoerlichScholzZimmermannetal.2015,
  author    = {G{\"o}rlich, Petra and Scholz, Jana and Zimmermann, Matthias and Kampe, Heike and Horn-Conrad, Antje and Engel, Silke and Lux, Nadine and J{\"a}ger, Heidi},
  title     = {Portal = Projekte und Visionen: das Ph{\"a}nomen Licht},
  number    = {03/2015},
  organization    = {Universit{\"a}t Potsdam, Referat f{\"u}r Presse- und {\"O}ffentlichkeitsarbeit},
  issn      = {1618-6893},
  doi       = {10.25932/publishup-44064},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-440641},
  pages     = {46},
  year      = {2015},
  abstract  = {Aus dem Inhalt: - Projekte und Visionen: das Ph{\"a}nomen Licht - Die Neuen sind da! - Tauwetter im Permafrost},
  language  = {de}
}
@misc{SzameitatWilkensGoerlichetal.2015,
  author    = {Szameitat, Ulrike and Wilkens, Martin and G{\"o}rlich, Petra and Horn-Conrad, Antje and Zimmermann, Matthias and Reinhardt, Kristin and Kampe, Heike and J{\"a}ger, Heidi and Wenzel, Anna Theresa and Scholz, Jana},
  title     = {Portal = Unter einem Dach: Lehrerbildung und Bildungsforschung},
  number    = {02/2015},
  organization    = {Universit{\"a}t Potsdam, Referat f{\"u}r Presse- und {\"O}ffentlichkeitsarbeit},
  issn      = {1618-6893},
  doi       = {10.25932/publishup-44063},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-440634},
  pages     = {46},
  year      = {2015},
  abstract  = {Aus dem Inhalt: - Unter einem Dach: Lehrerbildung und Bildungsforschung - Waldweit - Nicht ohne Eisen und Schwefel},
  language  = {de}
}
@misc{GuentherZimmermannKampeetal.2015,
  author    = {G{\"u}nther, Oliver and Zimmermann, Matthias and Kampe, Heike and Scholz, Jana and Eckardt, Barbara and Schmidt, Anna Theresa and G{\"o}rlich, Petra and Lux, Nadine and Szameitat, Ulrike and Ziemer, Franziska and J{\"a}ger, Heidi and Rost, Sophia},
  title     = {Portal = Konzepte und Visionen: St{\"a}dte der Zukunft},
  number    = {01/2015},
  organization    = {Universit{\"a}t Potsdam, Referat f{\"u}r Presse- und {\"O}ffentlichkeitsarbeit},
  issn      = {1618-6893},
  doi       = {10.25932/publishup-44062},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-440624},
  pages     = {42},
  year      = {2015},
  abstract  = {Aus dem Inhalt: - Konzepte und Visionen: St{\"a}dte der Zukunft - Uni plant Entwicklung bis 2018 - Was gl{\"a}nzt und was fehlt},
  language  = {de}
}
@misc{Doering2015,
  author    = {D{\"o}ring, Matthias},
  title     = {Das Streben nach Qualit{\"a}t},
  series = {Postprints der Universit{\"a}t Potsdam Wirtschafts- und Sozialwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam Wirtschafts- und Sozialwissenschaftliche Reihe},
  number    = {111},
  issn      = {1867-5808},
  doi       = {10.25932/publishup-43536},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-435366},
  pages     = {36 -- 45},
  year      = {2015},
  abstract  = {Qualit{\"a}t ist in den letzten Jahren zu einem intensiv diskutierten Thema im Gesundheitswesen geworden. Nach Hygiene- und Behand lungsskandalen steht vor allem der Krankenhaussektor unter Druck. Und obwohl in den vergangenen 15 Jahren eine ganze Reihe an Mechanismen und Regularien eingef{\"u}hrt wurde, so ist der Bereich nur teilweise erforscht. Dieser Artikel liefert einen {\"U}berblick {\"u}ber die Komplexit{\"a}t des Qualit{\"a}tsbegriffs. Anschließend wird die Landschaft der Instrumente zur Qualit{\"a}tskontrolle und -sicherung im deutschen Krankenhaussektor vorgestellt. Erkenntnisse aus der internationalen Forschung sollen einen vertieften Einblick in die Wirkungsweise gew{\"a}hren und weitere Forschungsl{\"u}cken betonen.},
  language  = {de}
}
@misc{PechouskovaDammhahnBrameieretal.2015,
  author    = {Pechouskova, Eva and Dammhahn, Melanie and Brameier, Markus and Fichtel, Claudia and Kappeler, Peter M. and Huchard, Elise},
  title     = {MHC class II variation in a rare and ecological specialist mouse lemur reveals lower allelic richness and contrasting selection patterns compared to a generalist and widespread sympatric congener},
  series = {Postprints der Universit{\"a}t Potsdam Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam Mathematisch-Naturwissenschaftliche Reihe},
  number    = {728},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-42978},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-429789},
  pages     = {229 -- 245},
  year      = {2015},
  abstract  = {The polymorphism of immunogenes of the major histocompatibility complex (MHC) is thought to influence the functional plasticity of immune responses and, consequently, the fitness of populations facing heterogeneous pathogenic pressures. Here, we evaluated MHC variation (allelic richness and divergence) and patterns of selection acting on the two highly polymorphic MHC class II loci (DRB and DQB) in the endangered primate Madame Berthe's mouse lemur (Microcebus berthae). Using 454 pyrosequencing, we examined MHC variation in a total of 100 individuals sampled over 9 years in Kirindy Forest, Western Madagascar, and compared our findings with data obtained previously for its sympatric congener, the grey mouse lemur (Microcebus murinus). These species exhibit a contrasting ecology and demography that were expected to affect MHC variation and molecular signatures of selection. We found a lower allelic richness concordant with its low population density, but a similar level of allelic divergence and signals of historical selection in the rare feeding specialist M. berthae compared to the widespread generalist M. murinus. These findings suggest that demographic factors may exert a stronger influence than pathogen-driven selection on current levels of allelic richness in M. berthae. Despite a high sequence similarity between the two congeners, contrasting selection patterns detected at DQB suggest its potential functional divergence. This study represents a first step toward unravelling factors influencing the adaptive divergence of MHC genes between closely related but ecologically differentiated sympatric lemurs and opens new questions regarding potential functional discrepancy that would explain contrasting selection patterns detected at DQB.},
  language  = {en}
}
@misc{ElsnerSchiblerHofreiteretal.2015,
  author    = {Elsner, Julia and Schibler, J{\"o}rg and Hofreiter, Michael and Schlumbaum, Angela},
  title     = {Burial condition is the most important factor for mtDNA PCR amplification success in Palaeolithic equid remains from the Alpine foreland},
  series = {Postprints der Universit{\"a}t Potsdam Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam Mathematisch-Naturwissenschaftliche Reihe},
  number    = {727},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-42976},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-429763},
  pages     = {505 -- 515},
  year      = {2015},
  abstract  = {Faunal remains from Palaeolithic sites are important genetic sources to study preglacial and postglacial populations and to investigate the effect of climate change and human impact. Post mortem decay, resulting in fragmented and chemically modified DNA, is a key obstacle in ancient DNA analyses. In the absence of reliable methods to determine the presence of endogenous DNA in sub-fossil samples, temporal and spatial surveys of DNA survival on a regional scale may help to estimate the potential of faunal remains from a given time period and region. We therefore investigated PCR amplification success, PCR performance and post mortem damage in c. 47,000 to c. 12,000-year-old horse remains from 14 Palaeolithic sites along the Swiss Jura Mountains in relation to depositional context, tissue type, storage time and age, potentially influencing DNA preservation. The targeted 75 base pair mitochondrial DNA fragment could be amplified solely from equid remains from caves and not from any of the open dry and (temporary) wetland sites. Whether teeth are better than bones cannot be ultimately decided; however, both storage time after excavation and age significantly affect PCR amplification and performance, albeit not in a linear way. This is best explained by the—inevitable—heterogeneity of the data set. The extent of post mortem damage is not related to any of the potential impact factors. The results encourage comprehensive investigations of Palaeolithic cave sites, even from temperate regions.},
  language  = {en}
}
@misc{KallmeyerGreweGlombitzaetal.2015,
  author    = {Kallmeyer, Jens and Grewe, Sina and Glombitza, Clemens and Kitte, J. Axel},
  title     = {Microbial abundance in lacustrine sediments},
  series = {Postprints der Universit{\"a}t Potsdam Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam Mathematisch-Naturwissenschaftliche Reihe},
  number    = {723},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-42982},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-429828},
  pages     = {1667 -- 1677},
  year      = {2015},
  abstract  = {The ICDP "PaleoVan" drilling campaign at Lake Van, Turkey, provided a long (> 100 m) record of lacustrine subsurface sedimentary microbial cell abundance. After the ICDP campaign at Potrok Aike, Argentina, this is only the second time deep lacustrine cell counts have been documented. Two sites were cored and revealed a strikingly similar cell distribution despite differences in organic matter content and microbial activity. Although shifted towards higher values, cell counts from Lake Potrok Aike, Argentina, reveal very similar distribution patterns with depth. The lacustrine cell count data are significantly different from published marine records; the most probable cause is differences in sedimentary organic matter composition with marine sediments containing a higher fraction of labile organic matter. Previous studies showed that microbial activity and abundance increase centimetres to metres around geologic interfaces. The finely laminated Lake Van sediment allowed studying this phenomenon on the microscale. We sampled at the scale of individual laminae, and in some depth intervals, we found large differences in microbial abundance between the different laminae. This small-scale heterogeneity is normally overlooked due to much larger sampling intervals that integrate over several centimetres. However, not all laminated intervals exhibit such large differences in microbial abundance, and some non-laminated horizons show large variability on the millimetre scale as well. The reasons for such contrasting observations remain elusive, but indicate that heterogeneity of microbial abundance in subsurface sediments has not been taken into account sufficiently. These findings have implications not just for microbiological studies but for geochemistry as well, as the large differences in microbial abundance clearly show that there are distinct microhabitats that deviate considerably from the surrounding layers.},
  language  = {en}
}
@misc{Blaut2015,
  author    = {Blaut, Michael},
  title     = {Gut microbiota and energy balance},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
  number    = {602},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-41446},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-414462},
  pages     = {227 -- 234},
  year      = {2015},
  abstract  = {The microbial community populating the human digestive tract has been linked to the development of obesity, diabetes and liver diseases. Proposed mechanisms on how the gut microbiota could contribute to obesity and metabolic diseases include: (1) improved energy extraction from diet by the conversion of dietary fibre to SCFA; (2) increased intestinal permeability for bacterial lipopolysaccharides (LPS) in response to the consumption of high-fat diets resulting in an elevated systemic LPS level and low-grade inflammation. Animal studies indicate differences in the physiologic effects of fermentable and non-fermentable dietary fibres as well as differences in long-and short-term effects of fermentable dietary fibre. The human intestinal microbiome is enriched in genes involved in the degradation of indigestible polysaccharides. The extent to which dietary fibres are fermented and in which molar ratio SCFA are formed depends on their physicochemical properties and on the individual microbiome. Acetate and propionate play an important role in lipid and glucose metabolism. Acetate serves as a substrate for de novo lipogenesis in liver, whereas propionate can be utilised for gluconeogenesis. The conversion of fermentable dietary fibre to SCFA provides additional energy to the host which could promote obesity. However, epidemiologic studies indicate that diets rich in fibre rather prevent than promote obesity development. This may be due to the fact that SCFA are also ligands of free fatty acid receptors (FFAR). Activation of FFAR leads to an increased expression and secretion of enteroendocrine hormones such as glucagon-like-peptide 1 or peptide YY which cause satiety. In conclusion, the role of SCFA in host energy balance needs to be re-evaluated.},
  language  = {en}
}
@misc{KrauseBoschClahsen2015,
  author    = {Krause, Helena and Bosch, Sina and Clahsen, Harald},
  title     = {Morphosyntax in the bilingual mental lexicon},
  series = {Postprints der Universit{\"a}t Potsdam Humanwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam Humanwissenschaftliche Reihe},
  number    = {528},
  issn      = {1866-8364},
  doi       = {10.25932/publishup-41547},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-415478},
  pages     = {25},
  year      = {2015},
  abstract  = {Although morphosyntax has been identified as a major source of difficulty for adult (nonnative) language learners, most previous studies have examined a limited set of largely affix-based phenomena. Little is known about word-based morphosyntax in late bilinguals and of how morphosyntax is represented and processed in a nonnative speaker's lexicon. To address these questions, we report results from two behavioral experiments investigating stem variants of strong verbs in German (which encode features such as tense, person, and number) in groups of advanced adult learners as well as native speakers of German. Although the late bilinguals were highly proficient in German, the results of a lexical priming experiment revealed clear native-nonnative differences. We argue that lexical representation and processing relies less on morphosyntactic information in a nonnative than in a native language.},
  language  = {en}
}
@misc{Wiese2015,
  author    = {Wiese, Heike},
  title     = {"This migrants' babble is not a German dialect!"},
  series = {Postprints der Universit{\"a}t Potsdam : Philosopische Fakult{\"a}t},
  journal   = {Postprints der Universit{\"a}t Potsdam : Philosopische Fakult{\"a}t},
  number    = {157},
  issn      = {1866-8380},
  doi       = {10.25932/publishup-41476},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-414764},
  pages     = {28},
  year      = {2015},
  abstract  = {This article investigates a public debate in Germany that put a special spotlight on the interaction of standard language ideologies with social dichotomies, centering on the question of whether Kiezdeutsch, a new way of speaking in multilingual urban neighbourhoods, is a legitimate German dialect. Based on a corpus of emails and postings to media websites, I analyse central topoi in this debate and an underlying narrative on language and identity. Central elements of this narrative are claims of cultural elevation and cultural unity for an idealised standard language High German', a view of German dialects as part of a national folk culture, and the construction of an exclusive in-group of German' speakers who own this language and its dialects. The narrative provides a potent conceptual frame for the Othering of Kiezdeutsch and its speakers, and for the projection of social and sometimes racist deliminations onto the linguistic plane.},
  language  = {en}
}
@misc{GebserHarrisonKaminskietal.2015,
  author    = {Gebser, Martin and Harrison, Amelia and Kaminski, Roland and Lifschitz, Vladimir and Schaub, Torsten H.},
  title     = {Abstract gringo},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {592},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-41475},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-414751},
  pages     = {15},
  year      = {2015},
  abstract  = {This paper defines the syntax and semantics of the input language of the ASP grounder gringo. The definition covers several constructs that were not discussed in earlier work on the semantics of that language, including intervals, pools, division of integers, aggregates with non-numeric values, and lparse-style aggregate expressions. The definition is abstract in the sense that it disregards some details related to representing programs by strings of ASCII characters. It serves as a specification for gringo from Version 4.5 on.},
  language  = {en}
}
@misc{WolffSchindlerBrand2015,
  author    = {Wolff, Wanja and Schindler, Sebastian and Brand, Ralf},
  title     = {The effect of implicitly incentivized faking on explicit and implicit measures of doping attitude},
  series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  number    = {524},
  issn      = {1866-8364},
  doi       = {10.25932/publishup-40985},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-409854},
  pages     = {10},
  year      = {2015},
  abstract  = {The Implicit Association Test (IAT) aims to measure participants' automatic evaluation of an attitude object and is useful especially for the measurement of attitudes related to socially sensitive subjects, e.g. doping in sports. Several studies indicate that IAT scores can be faked on instruction. But fully or semi-instructed research scenarios might not properly reflect what happens in more realistic situations, when participants secretly decide to try faking the test. The present study is the first to investigate IAT faking when there is only an implicit incentive to do so. Sixty-five athletes (22.83 years +/- 2.45; 25 women) were randomly assigned to an incentive-to-fake condition or a control condition. Participants in the incentive-to-fake condition were manipulated to believe that athletes with lenient doping attitudes would be referred to a tedious 45-minute anti-doping program. Attitudes were measured with the pictorial doping brief IAT (BIAT) and with the Performance Enhancement Attitude Scale (PEAS). A one-way MANOVA revealed significant differences between conditions after the manipulation in PEAS scores, but not in the doping BIAT. In the light of our hypothesis this suggests that participants successfully faked an exceedingly negative attitude to doping when completing the PEAS, but were unsuccessful in doing so on the reaction time-based test. This study assessed BIAT faking in a setting that aimed to resemble a situation in which participants want to hide their attempts to cheat. The two measures of attitude were differentially affected by the implicit incentive. Our findings provide evidence that the pictorial doping BIAT is relatively robust against spontaneous and naive faking attempts. (B) IATs might be less prone to faking than implied by previous studies.},
  language  = {en}
}
@misc{DammhahnRakotondramananaGoodman2015,
  author    = {Dammhahn, Melanie and Rakotondramanana, Claude Fabienne and Goodman, Steven M.},
  title     = {Coexistence of morphologically similar bats (Vespertilionidae) on Madagascar},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {590},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-41472},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-414729},
  pages     = {12},
  year      = {2015},
  abstract  = {Based on niche theory, closely related and morphologically similar species are not predicted to coexist due to overlap in resource and habitat use. Local assemblages of bats often contain cryptic taxa, which co-occur despite notable similarities in morphology and ecology. We measured in two different habitat types on Madagascar levels of stable carbon and nitrogen isotopes in hair (n = 103) and faeces (n = 57) of cryptic Vespertilionidae taxa to indirectly examine whether fine-grained trophic niche differentiation explains their coexistence. In the dry deciduous forest (Kirindy), six sympatric species ranged over 6.0\% in delta N-15, i.e. two trophic levels, and 4.2\% in delta C-13 with a community mean of 11.3\% in delta N-15 and - 21.0\% in delta C-13. In the mesic forest (Antsahabe), three sympatric species ranged over one trophic level (delta N-15: 2.4\%, delta C-13: 1.0\%) with a community mean of 8.0\% delta N-15 and - 21.7\% in delta C-13. Multivariate analyses and residual permutation of Euclidian distances in delta C-13- delta N-15 bi-plots revealed in both communities distinct stable isotope signatures and species separation for the hair samples among coexisting Vespertilionidae. Intraspecific variation in faecal and hair stable isotopes did not indicate that seasonal migration might relax competition and thereby facilitate the local co-occurrence of sympatric taxa.},
  language  = {en}
}
@misc{HoosKaminskiLindaueretal.2015,
  author    = {Hoos, Holger and Kaminski, Roland and Lindauer, Marius and Schaub, Torsten H.},
  title     = {aspeed},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {588},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-41474},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-414743},
  pages     = {26},
  year      = {2015},
  abstract  = {Although Boolean Constraint Technology has made tremendous progress over the last decade, the efficacy of state-of-the-art solvers is known to vary considerably across different types of problem instances, and is known to depend strongly on algorithm parameters. This problem was addressed by means of a simple, yet effective approach using handmade, uniform, and unordered schedules of multiple solvers in ppfolio, which showed very impressive performance in the 2011 Satisfiability Testing (SAT) Competition. Inspired by this, we take advantage of the modeling and solving capacities of Answer Set Programming (ASP) to automatically determine more refined, that is, nonuniform and ordered solver schedules from the existing benchmarking data. We begin by formulating the determination of such schedules as multi-criteria optimization problems and provide corresponding ASP encodings. The resulting encodings are easily customizable for different settings, and the computation of optimum schedules can mostly be done in the blink of an eye, even when dealing with large runtime data sets stemming from many solvers on hundreds to thousands of instances. Also, the fact that our approach can be customized easily enabled us to swiftly adapt it to generate parallel schedules for multi-processor machines.},
  language  = {en}
}
@misc{BohlkenWeberRappetal.2015,
  author    = {Bohlken, Jens and Weber, Simon and Rapp, Michael A. and Kostev, Karel},
  title     = {Continuous treatment with antidementia drugs in Germany 2003-2013},
  series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  number    = {522},
  issn      = {1866-8364},
  doi       = {10.25932/publishup-41471},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-414718},
  pages     = {8},
  year      = {2015},
  abstract  = {Background: Continuous treatment is an important indicator of medication adherence in dementia. However, long-term studies in larger clinical settings are lacking, and little is known about moderating effects of patient and service characteristics. Methods: Data from 12,910 outpatients with dementia (mean age 79.2 years; SD = 7.6 years) treated between January 2003 and December 2013 in Germany were included. Continuous treatment was analysed using Kaplan-Meier curves and log-rank tests. In addition, multivariate Cox regression models were fitted with continuous treatment as dependent variable and the predictors antidementia agent, age, gender, medical comorbidities, physician specialty, and health insurance status. Results: After one year of follow-up, nearly 60\% of patients continued drug treatment. Donezepil (HR: 0.88; 95\% CI: 0.82-0.95) and memantine (HR: 0.85; 0.79-0.91) patients were less likely to be discontinued treatment as compared to rivastigmine users. Patients were less likely to be discontinued if they were treated by specialist physicians as compared to general practitioners (HR: 0.44; 0.41-0.48). Younger male patients and patients who had private health insurance had a lower discontinuation risk. Regarding comorbidity, patients were more likely to be continuously treated with the index substance if a diagnosis of heart failure or hypertension had been diagnosed at baseline. Conclusions: Our results imply that besides type of antidementia agent, involvement of a specialist in the complex process of prescribing antidementia drugs can provide meaningful benefits to patients, in terms of more disease-specific and continuous treatment.},
  language  = {en}
}
@misc{DallmeyerClaussenFischeretal.2015,
  author    = {Dallmeyer, Anne and Claussen, M. and Fischer, N. and Haberkorn, K. and Wagner, S. and Pfeiffer, M. and Jin, L. and Khon, Vyacheslav and Wang, Y. and Herzschuh, Ulrike},
  title     = {The evolution of sub-monsoon systems in the Afro-Asian monsoon region during the Holocene},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {587},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-40972},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-409727},
  pages     = {22},
  year      = {2015},
  abstract  = {The recently proposed global monsoon hypothesis interprets monsoon systems as part of one global-scale atmospheric overturning circulation, implying a connection between the regional monsoon systems and an in-phase behaviour of all northern hemispheric monsoons on annual timescales (Trenberth et al., 2000). Whether this concept can be applied to past climates and variability on longer timescales is still under debate, because the monsoon systems exhibit different regional characteristics such as different seasonality (i. e. onset, peak and withdrawal). To investigate the interconnection of different monsoon systems during the pre-industrial Holocene, five transient global climate model simulations have been analysed with respect to the rainfall trend and variability in different sub-domains of the Afro-Asian monsoon region. Our analysis suggests that on millennial timescales with varying orbital forcing, the monsoons do not behave as a tightly connected global system. According to the models, the Indian and North African monsoons are coupled, showing similar rainfall trend and moderate correlation in centennial rainfall variability in all models. The East Asian monsoon changes independently during the Holocene. The dissimilarities in the seasonality of the monsoon sub-systems lead to a stronger response of the North African and Indian monsoon systems to the Holocene insolation forcing than of the East Asian monsoon and affect the seasonal distribution of Holocene rainfall variations. Within the Indian and North African monsoon domain, precipitation solely changes during the summer months, showing a decreasing Holocene precipitation trend. In the East Asian monsoon region, the precipitation signal is determined by an increasing precipitation trend during spring and a decreasing precipitation change during summer, partly balancing each other. A synthesis of reconstructions and the model results do not reveal an impact of the different seasonality on the timing of the Holocene rainfall optimum in the different sub-monsoon systems. Rather they indicate locally inhomogeneous rainfall changes and show that single palaeo-records should not be used to characterise the rainfall change and monsoon evolution for entire monsoon sub-systems.},
  language  = {en}
}