@misc{WetzelKempkaKuehn2017, author = {Wetzel, Maria and Kempka, Thomas and K{\"u}hn, Michael}, title = {Predicting macroscopic elastic rock properties requires detailed information on microstructure}, series = {Energy procedia}, volume = {125}, journal = {Energy procedia}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1876-6102}, doi = {10.1016/j.egypro.2017.08.195}, pages = {561 -- 570}, year = {2017}, abstract = {Predicting variations in macroscopic mechanical rock behaviour due to microstructural changes, driven by mineral precipitation and dissolution is necessary to couple chemo-mechanical processes in geological subsurface simulations. We apply 3D numerical homogenization models to estimate Young's moduli for five synthetic microstructures, and successfully validate our results for comparable geometries with the analytical Mori-Tanaka approach. Further, we demonstrate that considering specific rock microstructures is of paramount importance, since calculated elastic properties may deviate by up to 230 \% for the same mineral composition. Moreover, agreement between simulated and experimentally determined Young's moduli is significantly improved, when detailed spatial information are employed.}, language = {en} } @misc{KuehnLiNakatenetal.2017, author = {K{\"u}hn, Michael and Li, Qi and Nakaten, Natalie Christine and Kempka, Thomas}, title = {Integrated subsurface gas storage of CO2 and CH4 offers capacity and state-of-the-art technology for energy storage in China}, series = {Energy procedia}, volume = {125}, journal = {Energy procedia}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1876-6102}, doi = {10.1016/j.egypro.2017.08.039}, pages = {14 -- 18}, year = {2017}, abstract = {Integration and development of the energy supply in China and worldwide is a challenge for the years to come. The innovative idea presented here is based on an extension of the "power-to-gas-to-power" technology by establishing a closed carbon cycle. It is an implementation of a low-carbon energy system based on carbon dioxide capture and storage (CCS) to store and reuse wind and solar energy. The Chenjiacun storage project in China compares well with the German case study for the towns Potsdam and Brandenburg/Havel in the Federal State of Brandenburg based on the Ketzin pilot site for CCS.}, language = {en} } @misc{KuehnKempkadeLuciaetal.2017, author = {K{\"u}hn, Michael and Kempka, Thomas and de Lucia, Marco and Scheck-Wenderoth, Magdalena}, title = {Dissolved CO2 storage in geological formations with low pressure, low risk and large capacities}, series = {Energy procedia}, volume = {114}, journal = {Energy procedia}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1876-6102}, doi = {10.1016/j.egypro.2017.03.1607}, pages = {4722 -- 4727}, year = {2017}, abstract = {Geological CO2 storage is a mitigation technology to reduce CO2 emissions from fossil fuel combustion. However, major concerns are the pressure increase and saltwater displacement in the mainly targeted deep groundwater aquifers due to injection of supercritical CO2. The suggested solution is storage of CO2 exclusively in the dissolved state. In our exemplary regional case study of the North East German Basin based on a highly resolved temperature and pressure distribution model and a newly developed reactive transport coupling, we have quantified that 4.7 Gt of CO2 can be stored in solution compared to 1.5 Gt in the supercritical state.}, language = {en} } @article{PyšekPerglEssletal.2017, author = {Pyšek, Petr and Pergl, Jan and Essl, Franz and Lenzner, Bernd and Dawson, Wayne and Kreft, Holger and Weigelt, Patrick and Winter, Marten and Kartesz, John and Nishino, Misako and Antonova, Liubov A. and Barcelona, Julie F. and Cabezas, Francisco Jos{\´e} and C{\´a}rdenas L{\´o}pez, Dairon and C{\´a}rdenas-Toro, Juliana and Castańo, Nicol{\´a}s and Chac{\´o}n, Eduardo and Chatelain, Cyrille and Dullinger, Stefan and Ebel, Aleksandr L. and Figueiredo, Estrela and Fuentes, Nicol and Genovesi, Piero and Groom, Quentin J. and Henderson, Lesley and Inderjit, and Kupriyanov, Andrey and Masciadri, Silvana and Maurel, No{\"e}lie and Meerman, Jan and Morozova, Olʹga V. and Moser, Dietmar and Nickrent, Daniel and Nowak, Pauline M. and Pagad, Shyama and Patzelt, Annette and Pelser, Pieter B. and Seebens, Hanno and Shu, Wen-sheng and Thomas, Jacob and Velayos, Mauricio and Weber, Ewald and Wieringa, Jan J. and Baptiste, Maria P. and Kleunen, Mark van}, title = {Naturalized alien flora of the world}, series = {Preslia : the journal of the Czech Botanical Society}, volume = {89}, journal = {Preslia : the journal of the Czech Botanical Society}, number = {3}, publisher = {Czech Botanical Soc.}, address = {Praha}, issn = {0032-7786}, doi = {10.23855/preslia.2017.203}, pages = {203 -- 274}, year = {2017}, abstract = {Using the recently built Global Naturalized Alien Flora (GloNAF) database, containing data on the distribution of naturalized alien plants in 483 mainland and 361 island regions of the world, we describe patterns in diversity and geographic distribution of naturalized and invasive plant species, taxonomic, phylogenetic and life-history structure of the global naturalized flora as well as levels of naturalization and their determinants. The mainland regions with the highest numbers of naturalized aliens are some Australian states (with New South Wales being the richest on this continent) and several North American regions (of which California with 1753 naturalized plant species represents the world’s richest region in terms of naturalized alien vascular plants). England, Japan, New Zealand and the Hawaiian archipelago harbour most naturalized plants among islands or island groups. These regions also form the main hotspots of the regional levels of naturalization, measured as the percentage of naturalized aliens in the total flora of the region. Such hotspots of relative naturalized species richness appear on both the western and eastern coasts of North America, in north-western Europe, South Africa, south-eastern Australia, New Zealand, and India. High levels of island invasions by naturalized plants are concentrated in the Pacific, but also occur on individual islands across all oceans. The numbers of naturalized species are closely correlated with those of native species, with a stronger correlation and steeper increase for islands than mainland regions, indicating a greater vulnerability of islands to invasion by species that become successfully naturalized. South Africa, India, California, Cuba, Florida, Queensland and Japan have the highest numbers of invasive species. Regions in temperate and tropical zonobiomes harbour in total 9036 and 6774 naturalized species, respectively, followed by 3280 species naturalized in the Mediterranean zonobiome, 3057 in the subtropical zonobiome and 321 in the Arctic. The New World is richer in naturalized alien plants, with 9905 species compared to 7923 recorded in the Old World. While isolation is the key factor driving the level of naturalization on islands, zonobiomes differing in climatic regimes, and socioeconomy represented by per capita GDP, are central for mainland regions. The 11 most widely distributed species each occur in regions covering about one third of the globe or more in terms of the number of regions where they are naturalized and at least 35\% of the Earth’s land surface in terms of those regions’ areas, with the most widely distributed species Sonchus oleraceus occuring in 48\% of the regions that cover 42\% of the world area. Other widely distributed species are Ricinus communis, Oxalis corniculata, Portulaca oleracea, Eleusine indica, Chenopodium album, Capsella bursa-pastoris, Stellaria media, Bidens pilosa, Datura stramonium and Echinochloa crus-galli. Using the occurrence as invasive rather than only naturalized yields a different ranking, with Lantana camara (120 regions out of 349 for which data on invasive status are known), Calotropis procera (118), Eichhornia crassipes (113), Sonchus oleraceus (108) and Leucaena leucocephala (103) on top. As to the life-history spectra, islands harbour more naturalized woody species (34.4\%) thanmainland regions (29.5\%), and fewer annual herbs (18.7\% compared to 22.3\%). Ranking families by their absolute numbers of naturalized species reveals that Compositae (1343 species), Poaceae (1267) and Leguminosae (1189) contribute most to the global naturalized alien flora. Some families are disproportionally represented by naturalized aliens on islands (Arecaceae, Araceae, Acanthaceae, Amaryllidaceae, Asparagaceae, Convolvulaceae, Rubiaceae, Malvaceae), and much fewer so on mainland (e.g. Brassicaceae, Caryophyllaceae, Boraginaceae). Relating the numbers of naturalized species in a family to its total global richness shows that some of the large species-rich families are over-represented among naturalized aliens (e.g. Poaceae, Leguminosae, Rosaceae, Amaranthaceae, Pinaceae), some under-represented (e.g. Euphorbiaceae, Rubiaceae), whereas the one richest in naturalized species, Compositae, reaches a value expected from its global species richness. Significant phylogenetic signal indicates that families with an increased potential of their species to naturalize are not distributed randomly on the evolutionary tree. Solanum (112 species), Euphorbia (108) and Carex (106) are the genera richest in terms of naturalized species; over-represented on islands are Cotoneaster, Juncus, Eucalyptus, Salix, Hypericum, Geranium and Persicaria, while those relatively richer in naturalized species on the mainland are Atriplex, Opuntia, Oenothera, Artemisia, Vicia, Galium and Rosa. The data presented in this paper also point to where information is lacking and set priorities for future data collection. The GloNAF database has potential for designing concerted action to fill such data gaps, and provide a basis for allocating resources most efficiently towards better understanding and management of plant invasions worldwide.}, language = {en} } @misc{PlauthSterzEberhardtetal.2017, author = {Plauth, Max and Sterz, Christoph and Eberhardt, Felix and Feinbube, Frank and Polze, Andreas}, title = {Assessing NUMA performance based on hardware event counters}, series = {IEEE International Parallel and Distributed Processing Symposium Workshops (IPDPSW)}, journal = {IEEE International Parallel and Distributed Processing Symposium Workshops (IPDPSW)}, publisher = {Institute of Electrical and Electronics Engineers}, address = {New York}, isbn = {978-0-7695-6149-3}, issn = {2164-7062}, doi = {10.1109/IPDPSW.2017.51}, pages = {904 -- 913}, year = {2017}, abstract = {Cost models play an important role for the efficient implementation of software systems. These models can be embedded in operating systems and execution environments to optimize execution at run time. Even though non-uniform memory access (NUMA) architectures are dominating today's server landscape, there is still a lack of parallel cost models that represent NUMA system sufficiently. Therefore, the existing NUMA models are analyzed, and a two-step performance assessment strategy is proposed that incorporates low-level hardware counters as performance indicators. To support the two-step strategy, multiple tools are developed, all accumulating and enriching specific hardware event counter information, to explore, measure, and visualize these low-overhead performance indicators. The tools are showcased and discussed alongside specific experiments in the realm of performance assessment.}, language = {en} } @misc{TorkuraSukmanaChengetal.2017, author = {Torkura, Kennedy A. and Sukmana, Muhammad Ihsan Haikal and Cheng, Feng and Meinel, Christoph}, title = {Leveraging cloud native design patterns for security-as-a-service applications}, series = {IEEE International Conference on Smart Cloud (SmartCloud)}, journal = {IEEE International Conference on Smart Cloud (SmartCloud)}, publisher = {Institute of Electrical and Electronics Engineers}, address = {New York}, isbn = {978-1-5386-3684-8}, doi = {10.1109/SmartCloud.2017.21}, pages = {90 -- 97}, year = {2017}, abstract = {This paper discusses a new approach for designing and deploying Security-as-a-Service (SecaaS) applications using cloud native design patterns. Current SecaaS approaches do not efficiently handle the increasing threats to computer systems and applications. For example, requests for security assessments drastically increase after a high-risk security vulnerability is disclosed. In such scenarios, SecaaS applications are unable to dynamically scale to serve requests. A root cause of this challenge is employment of architectures not specifically fitted to cloud environments. Cloud native design patterns resolve this challenge by enabling certain properties e.g. massive scalability and resiliency via the combination of microservice patterns and cloud-focused design patterns. However adopting these patterns is a complex process, during which several security issues are introduced. In this work, we investigate these security issues, we redesign and deploy a monolithic SecaaS application using cloud native design patterns while considering appropriate, layered security counter-measures i.e. at the application and cloud networking layer. Our prototype implementation out-performs traditional, monolithic applications with an average Scanner Time of 6 minutes, without compromising security. Our approach can be employed for designing secure, scalable and performant SecaaS applications that effectively handle unexpected increase in security assessment requests.}, language = {en} } @article{Ette2017, author = {Ette, Ottmar}, title = {Welterleben/Weiterleben}, series = {Daphnis : Zeitschrift f{\"u}r mittlere deutsche Literatur}, volume = {45}, journal = {Daphnis : Zeitschrift f{\"u}r mittlere deutsche Literatur}, number = {3-4}, publisher = {Editions Rodopi BV}, address = {Amsterdam}, issn = {0300-693X}, doi = {10.1163/18796583-04503002}, pages = {343 -- 388}, year = {2017}, abstract = {Welterleben and Weiterleben are what determine the second globalization (of four previously explored) whose constantly accelerating dynamic, vectorization, this essay explores. On the basis of selected writings of Georg Forster, Alexander von Humboldt, and Adelbert von Chamisso, the author highlights the increasing speed with which knowledge, especially in the experiential sciences, is produced and disseminated following the routes of ever-widening trade speeded along by globalization. The notion of 'vectopia' stands for the connection of utopia and uchronia in space and time in such a way that the experience of the world, expanded worldwide, contains within it a Weiter-Leben, a 'living-further' that is to be understood first in a spatial, and not yet temporal, sense, of what Forster called Erfahrungswissen, or 'experiential knowledge.' Vectopia, as elaborated here, has a material dimension that relates to the physical person, the body, the experience of the world that cannot occur without the constant changing of place, without a journeying that is again and again recommenced. Vectopia develops the projection of a life not from space or from time alone, but by their combination. Vectopia is more than a concept, it is a thought-figure: it is vitally connected to life, and thus a life-figure. It opens itself to a type of knowledge that stands almost at the threshold of a further life, indeed, of a Weiterleben that, opening itself to a 'living-onward,' resides beyond space, time, and movement.}, language = {en} } @misc{LimbergerScheibelTrappetal.2017, author = {Limberger, Daniel and Scheibel, Willy and Trapp, Matthias and D{\"o}llner, J{\"u}rgen Roland Friedrich}, title = {Mixed-projection treemaps}, series = {21st International Conference Information Visualisation (IV)}, journal = {21st International Conference Information Visualisation (IV)}, publisher = {Institute of Electrical and Electronics Engineers}, address = {Los Alamitos}, isbn = {978-1-5386-0831-9}, issn = {2375-0138}, doi = {10.1109/iV.2017.67}, pages = {164 -- 169}, year = {2017}, abstract = {This paper presents a novel technique for combining 2D and 2.5D treemaps using multi-perspective views to leverage the advantages of both treemap types. It enables a new form of overview+detail visualization for tree-structured data and contributes new concepts for real-time rendering of and interaction with treemaps. The technique operates by tilting the graphical elements representing inner nodes using affine transformations and animated state transitions. We explain how to mix orthogonal and perspective projections within a single treemap. Finally, we show application examples that benefit from the reduced interaction overhead.}, language = {en} } @misc{SaintDizierStede2017, author = {Saint-Dizier, Patrick and Stede, Manfred}, title = {Foundations of the language of argumentation}, series = {Argument \& computation}, volume = {8}, journal = {Argument \& computation}, number = {2 Special issue}, publisher = {IOS Press}, address = {Amsterdam}, issn = {1946-2166}, doi = {10.3233/AAC-170018}, pages = {91 -- 93}, year = {2017}, language = {en} } @misc{WaldripNivenAbeletal.2017, author = {Waldrip, Steven H. and Niven, Robert K. and Abel, Markus and Schlegel, Michael}, title = {Consistent maximum entropy representations of pipe flow networks}, series = {AIP conference proceedings}, volume = {1853}, journal = {AIP conference proceedings}, number = {1}, publisher = {American Institute of Physics}, address = {Melville}, isbn = {978-0-7354-1527-0}, issn = {0094-243X}, doi = {10.1063/1.4985365}, year = {2017}, abstract = {The maximum entropy method is used to predict flows on water distribution networks. This analysis extends the water distribution network formulation of Waldrip et al. (2016) Journal of Hydraulic Engineering (ASCE), by the use of a continuous relative entropy defined on a reduced parameter set. This reduction in the parameters that the entropy is defined over ensures consistency between different representations of the same network. The performance of the proposed reduced parameter method is demonstrated with a one-loop network case study.}, language = {en} } @misc{WaldripNivenAbeletal.2017, author = {Waldrip, Steven H. and Niven, Robert K. and Abel, Markus and Schlegel, Michael}, title = {Maximum entropy analysis of transport networks}, series = {AIP conference proceedings}, volume = {1853}, journal = {AIP conference proceedings}, number = {1}, publisher = {American Institute of Physics}, address = {Melville}, isbn = {978-0-7354-1527-0}, issn = {0094-243X}, doi = {10.1063/1.4985364}, pages = {8}, year = {2017}, abstract = {The maximum entropy method is used to derive an alternative gravity model for a transport network. The proposed method builds on previous methods which assign the discrete value of a maximum entropy distribution to equal the traffic flow rate. The proposed method however, uses a distribution to represent each flow rate. The proposed method is shown to be able to handle uncertainty in a more elegant way and give similar results to traditional methods. It is able to incorporate more of the observed data through the entropy function, prior distribution and integration limits potentially allowing better inferences to be made.}, language = {en} } @article{HartigPirro2017, author = {Hartig, Olaf and Pirr{\`o}, Giuseppe}, title = {SPARQL with property paths on the Web}, series = {Semantic web}, volume = {8}, journal = {Semantic web}, number = {6}, publisher = {IOS Press}, address = {Amsterdam}, issn = {1570-0844}, doi = {10.3233/SW-160237}, pages = {773 -- 795}, year = {2017}, abstract = {Linked Data on the Web represents an immense source of knowledge suitable to be automatically processed and queried. In this respect, there are different approaches for Linked Data querying that differ on the degree of centralization adopted. On one hand, the SPARQL query language, originally defined for querying single datasets, has been enhanced with features to query federations of datasets; however, this attempt is not sufficient to cope with the distributed nature of data sources available as Linked Data. On the other hand, extensions or variations of SPARQL aim to find trade-offs between centralized and fully distributed querying. The idea is to partially move the computational load from the servers to the clients. Despite the variety and the relative merits of these approaches, as of today, there is no standard language for querying Linked Data on theWeb. A specific requirement for such a language to capture the distributed, graph-like nature of Linked Data sources on the Web is a support of graph navigation. Recently, SPARQL has been extended with a navigational feature called property paths (PPs). However, the semantics of SPARQL restricts the scope of navigation via PPs to single RDF graphs. This restriction limits the applicability of PPs for querying distributed Linked Data sources on the Web. To fill this gap, in this paper we provide formal foundations for evaluating PPs on the Web, thus contributing to the definition of a query language for Linked Data. We first introduce a family of reachability-based query semantics for PPs that distinguish between navigation on the Web and navigation at the data level. Thereafter, we consider another, alternative query semantics that couples Web graph navigation and data level navigation; we call it context-based semantics. Given these semantics, we find that for some PP-based SPARQL queries a complete evaluation on the Web is not possible. To study this phenomenon we introduce a notion of Web-safeness of queries, and prove a decidable syntactic property that enables systems to identify queries that areWeb-safe. In addition to establishing these formal foundations, we conducted an experimental comparison of the context-based semantics and a reachability- based semantics. Our experiments show that when evaluating a PP-based query under the context-based semantics one experiences a significantly smaller number of dereferencing operations, but the computed query result may contain less solutions.}, language = {en} } @incollection{Kuegler2017, author = {K{\"u}gler, Frank}, title = {Tone and intonation in Akan}, series = {Intonation in African Tone Languages}, volume = {24}, booktitle = {Intonation in African Tone Languages}, publisher = {De Gruyter Mouton}, address = {Berlin}, isbn = {978-3-11-050352-4; 978-3-11-048479-3}, issn = {1861-4191}, doi = {10.1515/9783110503524-004}, pages = {89 -- 129}, year = {2017}, abstract = {This chapter provides an account of the intonation patterns in Akan (Kwa, Niger-Congo). Tonal processes such as downstep, tonal spreading and tonal replacement influence the surface tone pattern of a sentence. In general, any Akan utterance independent of sentence type shows a characteristic down-trend in pitch. This chapter proposes that Akan employs a simple post-lexical tonal grammar that accounts for the shapes of an intonation contour. The unmarked post-lexical structure is found in simple declaratives. The downward trend of an intonation contour is shaped by local tonal interactions (downstep), and sentence-final tonal neutralization. In polar questions, an iota-phrase-final low boundary tone (L\%) accounts for the intensity increase and lengthening of the final vowel compared to a declarative. Complex declaratives and left-dislocations show a partial pitch reset at the left edge of an embedded iota-phrase. Underlying lexical tones are not affected by intonation with the exception of sentence-final H-tones.}, language = {en} } @misc{GronauUllrichTeichmann2017, author = {Gronau, Norbert and Ullrich, Andr{\´e} and Teichmann, Malte}, title = {Development of the industrial IoT competences in the areas of organization, process, and interaction based on the learning factory concept}, series = {Procedia manufacturing}, volume = {9}, journal = {Procedia manufacturing}, publisher = {Elsevier}, address = {Amsterdam}, issn = {2351-9789}, doi = {10.1016/j.promfg.2017.04.029}, pages = {254 -- 261}, year = {2017}, abstract = {Lately, first implementation approaches of Internet of Things (IoT) technologies penetrate industrial value-adding processes. Within this, the competence requirements for employees are changing. Employees' organization, process, and interaction competences are of crucial importance in this new IoT environment, however, in students and vocational training not sufficiently considered yet. On the other hand, conventional learning factories evolve and transform to digital learning factories. Nevertheless, the integration of IoT technology and its usage for training in digital learning factories has been largely neglected thus far. Existing learning factories do not explicitly and properly consider IoT technology, which leads to deficiencies regarding an appropriate development of employees' Industrial IoT competences. The goal of this contribution is to point out a didactic concept that enables development and training of these new demanded competences by using an IoT laboratory. For this purpose, a design science approach is applied. The result of this contribution is a didactic concept for the development of Industrial IoT competences in an IoT laboratory.}, language = {en} } @article{ParamonovKuehnBandrauk2017, author = {Paramonov, Guennaddi K. and K{\"u}hn, Oliver and Bandrauk, Andr{\´e} D.}, title = {Excitation of H+ 2 with one-cycle laser pulses}, series = {Molecular physics : MP ; an international journal in the field of chemical physics}, volume = {115}, journal = {Molecular physics : MP ; an international journal in the field of chemical physics}, number = {15/16}, publisher = {Taylor \& Francis}, address = {London}, issn = {0026-8976}, doi = {10.1080/00268976.2017.1288938}, pages = {1846 -- 1860}, year = {2017}, abstract = {Non-Born-Oppenheimer quantum dynamics of H+ 2 excited by shaped one-cycle laser pulses linearly polarised along the molecular axis have been studied by the numerical solution of the time-dependent Schr{\"o}dinger equation within a three-dimensional model, including the internuclear separation, R, and the electron coordinates z and ρ. Laser carrier frequencies corresponding to the wavelengths λ l = 25 nm through λ l = 400 nm were used and the amplitudes of the pulses were chosen such that the energy of H+ 2 was close to its dissociation threshold at the end of any laser pulse applied. It is shown that there exists a characteristic oscillation frequency ωosc ≃ 0.2265 au (corresponding to the period of τosc ≃ 0.671 fs and the wavelength of λosc ≃ 201 nm) that manifests itself as a 'carrier' frequency of temporally shaped oscillations of the time-dependent expectation values ⟨z ⟩ and ⟨∂V/∂z ⟩ that emerge at the ends of the laser pulses and exist on a timescale of at least 50 fs. Time-dependent expectation values ⟨ρ⟩ and ⟨∂V /∂ρ⟩ of the optically passive degree of freedom, ρ, demonstrate post-laser-field oscillations at two basic frequencies ωρ 1 ≈ ωosc and ωρ 2 ≈ 2ωosc. Power spectra associated with the electronic motion show higher- and lower-order harmonics with respect to the driving field.}, language = {en} } @article{WiemersBekkeringLindemann2017, author = {Wiemers, Michael and Bekkering, Harold and Lindemann, Oliver}, title = {Is more always up?}, series = {Journal of cognitive psychology}, volume = {29}, journal = {Journal of cognitive psychology}, number = {5}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {2044-5911}, doi = {10.1080/20445911.2017.1302451}, pages = {642 -- 652}, year = {2017}, abstract = {It has been argued that the association of numbers and vertical space plays a fundamental role for the understanding of numerical concepts. However, convincing evidence for an association of numbers and vertical bimanual responses is still lacking. The present study tests the vertical Spatio-Numerical-Association-of-Response-Codes (SNARC) effect in a number classification task by comparing anatomical hand-based and spatial associations. A mixed effects model of linear spatial-numerical associations revealed no evidence for a vertical but clear support for an anatomical SNARC effect. Only if the task requirements prevented participants from using a number-hand association due to frequently alternating hand-to-button assignments, numbers were associated with the vertical dimension. Taken together, the present findings question the importance of vertical associations for the conceptual understanding of numerical magnitude as hypothesised by some embodied approaches to number cognition and suggest a preference for ego-over geocentric reference frames for the mapping of numbers onto space.}, language = {en} } @article{Richter2017, author = {Richter, Philipp}, title = {Gas accretion onto the Milky Way}, series = {Astrophysics and space science library}, volume = {430}, journal = {Astrophysics and space science library}, editor = {Fox, Andrew J. and Dav{\´e}, Romeel}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-52512-9}, issn = {0067-0057}, doi = {10.1007/978-3-319-52512-9_2}, pages = {15 -- 47}, year = {2017}, abstract = {The Milky Way is surrounded by large amounts of gaseous matter that are slowly being accreted over cosmic timescales to support star formation in the disk. The corresponding gas-accretion rate represents a key parameter for the past, present, and future evolution of the Milky Way. In this chapter, we discuss our current understanding of gas accretion processes in the Galaxy by reviewing past and recent observational and theoretical studies. The first part of this review deals with the spatial distribution of the different gas phases in the Milky Way halo, the origin of the gas, and its total mass. The second part discusses the gas dynamics and the physical processes that regulate the gas flow from the outer Galactic halo to the disk. From the most recent studies follows that the present-day gas accretion rate of the Milky Way is a few solar masses per year, which is sufficient to maintain the Galaxy's star-formation rate at its current level.}, language = {en} } @misc{Kay2017, author = {Kay, Alex James}, title = {Disagreement is fine. Misrepresentation is not}, series = {The international history review}, volume = {39}, journal = {The international history review}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0707-5332}, doi = {10.1080/07075332.2017.1354547}, pages = {929 -- 930}, year = {2017}, language = {en} } @misc{Giese2017, author = {Giese, Holger}, title = {Formal models and analysis for self-adaptive cyber-physical systems}, series = {Lecture notes in computer science}, volume = {10231}, journal = {Lecture notes in computer science}, editor = {Kouchnarenko, Olga and Khosravi, Ramtin}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-57666-4}, issn = {0302-9743}, doi = {10.1007/978-3-319-57666-4_1}, pages = {3 -- 9}, year = {2017}, abstract = {In this extended abstract, we will analyze the current challenges for the envisioned Self-Adaptive CPS. In addition, we will outline our results to approach these challenges with SMARTSOS [10] a generic approach based on extensions of graph transformation systems employing open and adaptive collaborations and models at runtime for trustworthy self-adaptation, self-organization, and evolution of the individual systems and the system-of-systems level taking the independent development, operation, management, and evolution of these systems into account.}, language = {en} } @misc{SerthPodlesnyBornsteinetal.2017, author = {Serth, Sebastian and Podlesny, Nikolai and Bornstein, Marvin and Lindemann, Jan and Latt, Johanna and Selke, Jan and Schlosser, Rainer and Boissier, Martin and Uflacker, Matthias}, title = {An interactive platform to simulate dynamic pricing competition on online marketplaces}, series = {2017 IEEE 21st International Enterprise Distributed Object Computing Conference (EDOC)}, journal = {2017 IEEE 21st International Enterprise Distributed Object Computing Conference (EDOC)}, publisher = {Institute of Electrical and Electronics Engineers}, address = {New York}, isbn = {978-1-5090-3045-3}, issn = {2325-6354}, doi = {10.1109/EDOC.2017.17}, pages = {61 -- 66}, year = {2017}, abstract = {E-commerce marketplaces are highly dynamic with constant competition. While this competition is challenging for many merchants, it also provides plenty of opportunities, e.g., by allowing them to automatically adjust prices in order to react to changing market situations. For practitioners however, testing automated pricing strategies is time-consuming and potentially hazardously when done in production. Researchers, on the other side, struggle to study how pricing strategies interact under heavy competition. As a consequence, we built an open continuous time framework to simulate dynamic pricing competition called Price Wars. The microservice-based architecture provides a scalable platform for large competitions with dozens of merchants and a large random stream of consumers. Our platform stores each event in a distributed log. This allows to provide different performance measures enabling users to compare profit and revenue of various repricing strategies in real-time. For researchers, price trajectories are shown which ease evaluating mutual price reactions of competing strategies. Furthermore, merchants can access historical marketplace data and apply machine learning. By providing a set of customizable, artificial merchants, users can easily simulate both simple rule-based strategies as well as sophisticated data-driven strategies using demand learning to optimize their pricing strategies.}, language = {en} } @article{SeiffertHolsteinSchlosseretal.2017, author = {Seiffert, Martin and Holstein, Flavio and Schlosser, Rainer and Schiller, Jochen}, title = {Next generation cooperative wearables}, series = {IEEE access : practical research, open solutions}, volume = {5}, journal = {IEEE access : practical research, open solutions}, publisher = {Institute of Electrical and Electronics Engineers}, address = {Piscataway}, issn = {2169-3536}, doi = {10.1109/ACCESS.2017.2749005}, pages = {16793 -- 16807}, year = {2017}, abstract = {Currently available wearables are usually based on a single sensor node with integrated capabilities for classifying different activities. The next generation of cooperative wearables could be able to identify not only activities, but also to evaluate them qualitatively using the data of several sensor nodes attached to the body, to provide detailed feedback for the improvement of the execution. Especially within the application domains of sports and health-care, such immediate feedback to the execution of body movements is crucial for (re-) learning and improving motor skills. To enable such systems for a broad range of activities, generalized approaches for human motion assessment within sensor networks are required. In this paper, we present a generalized trainable activity assessment chain (AAC) for the online assessment of periodic human activity within a wireless body area network. AAC evaluates the execution of separate movements of a prior trained activity on a fine-grained quality scale. We connect qualitative assessment with human knowledge by projecting the AAC on the hierarchical decomposition of motion performed by the human body as well as establishing the assessment on a kinematic evaluation of biomechanically distinct motion fragments. We evaluate AAC in a real-world setting and show that AAC successfully delimits the movements of correctly performed activity from faulty executions and provides detailed reasons for the activity assessment.}, language = {en} } @misc{LowHentschelStoberetal.2017, author = {Low, Thomas and Hentschel, Christian and Stober, Sebastian and Sack, Harald and N{\"u}rnberger, Andreas}, title = {Exploring large movie collections}, series = {Lecture notes in computer science}, volume = {10133}, journal = {Lecture notes in computer science}, editor = {Amsaleg, Laurent and Guðmundsson, Gylfi Þ{\´o}r and Gurrin, Cathal and J{\´o}nsson, Bj{\"o}rn Þ{\´o}r and Satoh, Shin'ichi}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-51814-5}, issn = {0302-9743}, doi = {10.1007/978-3-319-51814-5_17}, pages = {198 -- 208}, year = {2017}, abstract = {We compare Visual Berrypicking, an interactive approach allowing users to explore large and highly faceted information spaces using similarity-based two-dimensional maps, with traditional browsing techniques. For large datasets, current projection methods used to generate maplike overviews suffer from increased computational costs and a loss of accuracy resulting in inconsistent visualizations. We propose to interactively align inexpensive small maps, showing local neighborhoods only, which ideally creates the impression of panning a large map. For evaluation, we designed a web-based prototype for movie exploration and compared it to the web interface of The Movie Database (TMDb) in an online user study. Results suggest that users are able to effectively explore large movie collections by hopping from one neighborhood to the next. Additionally, due to the projection of movie similarities, interesting links between movies can be found more easily, and thus, compared to browsing serendipitous discoveries are more likely.}, language = {en} } @article{WieczorekKolmogorovKruseetal.2017, author = {Wieczorek, Mareike and Kolmogorov, Alexei and Kruse, Stefan and Jacobsen, Inga and Nitze, Ingmar and Nikolaev, Anatoly N. and Heinrich, Ingo and Pestryakova, Luidmila Agafyevna and Herzschuh, Ulrike}, title = {Disturbance-effects on treeline larch-stands in the lower Kolyma River area (NE Siberia)}, series = {Silva Fennica : a quarterly journal for forest science}, volume = {51}, journal = {Silva Fennica : a quarterly journal for forest science}, number = {3}, publisher = {The Finnish Society of Forest Science}, address = {Helsinki}, issn = {0037-5330}, doi = {10.14214/sf.1666}, pages = {20}, year = {2017}, abstract = {Tree stands in the boreal treeline ecotone are, in addition to climate change, impacted by disturbances such as fire, water-related disturbances and logging. We aim to understand how these disturbances affect growth, age structure, and spatial patterns of larch stands in the north-eastern Siberian treeline ecotone (lower Kolyma River region), an insufficiently researched region. Stand structure of Larix cajanderi Mayr was studied at seven sites impacted by disturbances. Maximum tree age ranged from 44 to 300 years. Young to medium-aged stands had, independent of disturbance type, the highest stand densities with over 4000 larch trees per ha. These sites also had the highest growth rates for tree height and stem diameter. Overall lowest stand densities were found in a polygonal field at the northern end of the study area, with larches growing in distinct " tree islands". At all sites, saplings are significantly clustered. Differences in fire severity led to contrasting stand structures with respect to tree, recruit, and overall stand densities. While a low severity fire resulted in low-density stands with high proportions of small and young larches, high severity fires resulted in high-density stands with high proportions of big trees. At waterdisturbed sites, stand structure varied between waterlogged and drained sites and latitude. These mixed effects of climate and disturbance make it difficult to predict future stand characteristics and the treeline position.}, language = {en} } @misc{FraschettiPohl2017, author = {Fraschetti, Federico and Pohl, Martin}, title = {Two-zone model for the broadband crab nebula spectrum}, series = {The European physical journal : Web of Conferences : proceedings}, volume = {136}, journal = {The European physical journal : Web of Conferences : proceedings}, publisher = {EDP Sciences}, address = {Les Ulis}, issn = {2100-014X}, doi = {10.1051/epjconf/201713602009}, pages = {5}, year = {2017}, abstract = {We develop a simple two-zone interpretation of the broadband baseline Crab nebula spectrum between 10(-5) eV and similar to 100 TeV by using two distinct log-parabola energetic electrons distributions. We determine analytically the very-high energy photon spectrum as originated by inverse-Compton scattering of the far-infrared soft ambient photons within the nebula off a first population of electrons energized at the nebula termination shock. The broad and flat 200 GeV peak jointly observed by Fermi/LAT and MAGIC is naturally reproduced. The synchrotron radiation from a second energetic electron population explains the spectrum from the radio range up to similar to 10 keV. We infer from observations the energy dependence of the microscopic probability of remaining in proximity of the shock of the accelerating electrons.}, language = {en} } @article{HoehnJerniganJaptoketal.2017, author = {Hoehn, Richard S. and Jernigan, Peter L. and Japtok, Lukasz and Chang, Alex L. and Midura, Emily F. and Caldwell, Charles C. and Kleuser, Burkhard and Lentsch, Alex B. and Edwards, Michael J. and Gulbins, Erich and Pritts, Timothy A.}, title = {Acid sphingomyelinase inhibition in stored erythrocytes reduces transfusion-associated lung inflammation}, series = {Annals of surgery : a monthly review of surgical science and practice}, volume = {265}, journal = {Annals of surgery : a monthly review of surgical science and practice}, number = {1}, publisher = {Lippincott Williams \& Wilkins}, address = {Philadelphia}, issn = {0003-4932}, doi = {10.1097/SLA.0000000000001648}, pages = {218 -- 226}, year = {2017}, abstract = {Objective: We aimed to identify the role of the enzyme acid sphingomyelinase in the aging of stored units of packed red blood cells (pRBCs) and subsequent lung inflammation after transfusion. Summary Background Data: Large volume pRBC transfusions are associated with multiple adverse clinical sequelae, including lung inflammation. Microparticles are formed in stored pRBCs over time and have been shown to contribute to lung inflammation after transfusion. Methods: Human and murine pRBCs were stored with or without amitriptyline, a functional inhibitor of acid sphingomyelinase, or obtained from acid sphingomyelinase-deficient mice, and lung inflammation was studied in mice receiving transfusions of pRBCs and microparticles isolated from these units. Results: Acid sphingomyelinase activity in pRBCs was associated with the formation of ceramide and the release of microparticles. Treatment of pRBCs with amitriptyline inhibited acid sphingomyelinase activity, ceramide accumulation, and microparticle production during pRBC storage. Transfusion of aged pRBCs or microparticles isolated from aged blood into mice caused lung inflammation. This was attenuated after transfusion of pRBCs treated with amitriptyline or from acid sphingomyelinase-deficient mice. Conclusions: Acid sphingomyelinase inhibition in stored pRBCs offers a novel mechanism for improving the quality of stored blood.}, language = {en} } @misc{YangDarkoHuangetal.2017, author = {Yang, Xiaoping and Darko, Kwame Oteng and Huang, Yanjun and He, Caimei and Yang, Huansheng and He, Shanping and Li, Jianzhong and Li, Jian and Hocher, Berthold and Yin, Yulong}, title = {Resistant starch regulates gut microbiota}, series = {Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology}, volume = {42}, journal = {Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology}, number = {1}, publisher = {Karger}, address = {Basel}, issn = {1015-8987}, doi = {10.1159/000477386}, pages = {306 -- 318}, year = {2017}, abstract = {Starch is one of the most popular nutritional sources for both human and animals. Due to the variation of its nutritional traits and biochemical specificities, starch has been classified into rapidly digestible, slowly digestible and resistant starch. Resistant starch has its own unique chemical structure, and various forms of resistant starch are commercially available. It has been found being a multiple-functional regulator for treating metabolic dysfunction. Different functions of resistant starch such as modulation of the gut microbiota, gut peptides, circulating growth factors, circulating inflammatory mediators have been characterized by animal studies and clinical trials. In this mini-review, recent remarkable progress in resistant starch on gut microbiota, particularly the effect of structure, biochemistry and cell signaling on nutrition has been summarized, with highlights on its regulatory effect on gut microbiota.}, language = {en} } @article{HeLiuLuetal.2017, author = {He, Jing and Liu, Zhi-Wei and Lu, Yong-Ping and Li, Tao-Yuan and Liang, Xu-Jing and Arck, Petra and Huang, Si-Min and Hocher, Berthold and Chen, You-Peng}, title = {A systematic review and meta-analysis of influenza a virus infection during pregnancy associated with an increased risk for stillbirth and low birth weight}, series = {Kidney \& blood pressure research : official organ of the Gesellschaft f{\"u}r Nephrologie ; official organ of the Deutsche Liga zur Bek{\"a}mpfung des Hohen Blutdruckes e.V., Deutsche Hypertonie-Gesellschaft}, volume = {42}, journal = {Kidney \& blood pressure research : official organ of the Gesellschaft f{\"u}r Nephrologie ; official organ of the Deutsche Liga zur Bek{\"a}mpfung des Hohen Blutdruckes e.V., Deutsche Hypertonie-Gesellschaft}, number = {2}, publisher = {Karger}, address = {Basel}, issn = {1420-4096}, doi = {10.1159/000477221}, pages = {232 -- 243}, year = {2017}, abstract = {Background/Aims: Impaired pregnancy outcomes, such as low birth weight are associated with increased disease risk in later life, however little is known about the impact of common infectious diseases during pregnancy on birth weight. The study had two aims: a) to investigate risk factors of influenza virus infection during pregnancy, and b) to analyze the impact of influenza virus infection on pregnancy outcome, especially birth weight. Methods: Prospective and retrospective observational studies found in PubMed, MEDLINE, Embase, Google Scholar, and WangFang database were included in this meta analysis. Data of included studies was extracted and analyzed by the RevMan software. Results: Pregnant women with anemia (P=0.004, RR=1.46, 95\% CI: 1.13-1.88), obesity (P<0.00001, RR=1.35, 95\% CI: 1.25-1.46) and asthma (P<0.00001, RR=1.99, 95\% CI: 1.67-2.37) had higher rates of influenza virus infection. Regarding birth outcomes, influenza A virus infection did not affect the likelihood for cesarean section. Mothers with influenza had a higher rate of stillbirth (P=0.04, RR=2.36, 95\% CI: 1.05-5.31), and their offspring had low 5-minute APGR Scores (P=0.009, RR=1.39, 95\% CI: 1.08-1.79). Furthermore, the rate for birth weight < 2500g (P=0.04, RR=1.71, 95\% CI: 1.03-2.84) was increased. Conclusion: Results of this study showed that anemia, asthma and obesity during pregnancy are risk factors influenza A virus infection during pregnancy. Moreover, gestational influenza A infection impairs pregnancy outcomes and increases the risk for low birth weight, a known risk factor for later life disease susceptibility.}, language = {en} } @article{ReichetzederHeunischvonEinemetal.2017, author = {Reichetzeder, Christoph and Heunisch, Fabian and von Einem, Gina-Franziska and Tsuprykov, Oleg and Kellner, Karl-Heinz and Dschietzig, Thomas and Kretschmer, Axel and Hocher, Berthold}, title = {Pre-interventional kynurenine predicts medium-term outcome after contrast media exposure due to coronary angiography}, series = {Kidney \& blood pressure research : official organ of the Gesellschaft f{\"u}r Nephrologie ; official organ of the Deutsche Liga zur Bek{\"a}mpfung des Hohen Blutdruckes e.V., Deutsche Hypertonie-Gesellschaft}, volume = {42}, journal = {Kidney \& blood pressure research : official organ of the Gesellschaft f{\"u}r Nephrologie ; official organ of the Deutsche Liga zur Bek{\"a}mpfung des Hohen Blutdruckes e.V., Deutsche Hypertonie-Gesellschaft}, number = {2}, publisher = {Karger}, address = {Basel}, issn = {1420-4096}, doi = {10.1159/000477222}, pages = {244 -- 256}, year = {2017}, abstract = {Background/Aims: Contrast induced acute kidney injury (CI-AKI) remains a serious complication of contrast media enhanced procedures like coronary angiography. There is still a lack of established biomarkers that help to identify patients at high risk for short and long-term complications. The aim of the current study was to evaluate plasma kynurenine as a predictive biomarker for CI-AKI and long-term complications, measured by the combined endpoint "major adverse kidney events" (MAKE) up to 120 days after CM application. Methods: In this prospective cohort study 245 patients undergoing coronary angiography were analyzed. Blood samples were obtained at baseline, 24h and 48h after contrast media (CM) application to diagnose CI-AKI. Patients were followed for 120 days for adverse clinical events including death, the need for dialysis, and a doubling of plasma creatinine. Occurrence of any of these events was summarized in the combined endpoint MAKE. Results: Preinterventional plasma kynurenine was not associated with CI-AKI. Patients who later developed MAKE displayed significantly increased preinterventional plasma kynurenine levels (p<0.0001). ROC analysis revealed that preinterventional kynurenine is highly predictive for MAKE (AUC=0.838; p<0.0001). The optimal cutoff was found at >= 3.5 mu mol/L. Using this cutoff, the Kaplan-Meier estimator demonstrated that concentrations of plasma kynurenine >= 3.5 mu mol/L were significantly associated with a higher prevalence of MAKE until follow up (p<0.0001). This association remained significant in multivariate Cox regression models adjusted for relevant factors of long-term renal outcome. Conclusion: Preinterventional plasma kynurenine might serve as a highly predictive biomarker for MAKE up to 120 days after coronary angiography.}, language = {en} } @article{XuLuHasanetal.2017, author = {Xu, Mei and Lu, Yong-Ping and Hasan, Ahmed A. and Hocher, Berthold}, title = {Plasma ET-1 concentrations are elevated in patients with hypertension meta-analysis of clinical studies}, series = {Kidney \& blood pressure research : official organ of the Gesellschaft f{\"u}r Nephrologie ; official organ of the Deutsche Liga zur Bek{\"a}mpfung des Hohen Blutdruckes e.V., Deutsche Hypertonie-Gesellschaft}, volume = {42}, journal = {Kidney \& blood pressure research : official organ of the Gesellschaft f{\"u}r Nephrologie ; official organ of the Deutsche Liga zur Bek{\"a}mpfung des Hohen Blutdruckes e.V., Deutsche Hypertonie-Gesellschaft}, number = {2}, publisher = {Karger}, address = {Basel}, issn = {1420-4096}, doi = {10.1159/000477572}, pages = {304 -- 313}, year = {2017}, abstract = {Background/Aims: A recent study revealed that global overexpression of ET-1 causes a slight reduction in systemic blood pressure. Moreover, heterozygous ET-1 knockout mice are hypertensive. The role of ET-1 in human hypertension was so far not addressed by a strict meta-analysis of published human clinical studies. Methods: We included studies published between January 1, 1990 and February 28, 2017. We included case control studies analyzing untreated essential hypertension or hypertensive patients where antihypertensive medication was discontinued for at least two weeks. Based on the principle of Cochrane systematic reviews, case control studies (CCSs) in PubMed (Medline) and Google Scholar designed to identify the role of endothelin-1 (ET-1) in the pathophysiological of hypertension were screened. Review Manager Version 5.0 (Rev-Man 5.0) was applied for statistical analysis. Mean difference and 95\% confidence interval (CI) were shown in inverse variance (IV) fixed-effects model or IV random-effects models. Results: Eleven studies fulfilling our in-and exclusion criteria were eligible for this meta-analysis. These studies included 450 hypertensive patients and 328 controls. Our meta-analysis revealed that ET-1 plasma concentrations were higher in hypertensive patients as compared to the control patients [mean difference between groups 1.57 pg/mL, 95\%Ci [0.47 similar to 2.68, P = 0.005]. These finding were driven by patients having systolic blood pressure higher than 160 mmHg and diastolic blood pressure higher than 100 mmHg. Conclusions: This meta-analysis showed that hypertensive patients do have elevated plasma ET-1 concentrations. This finding is driven by those patients with high systolic/diastolic blood pressure. Given that the ET-1 gene did not appear in any of the whole genome association studies searching for hypertension associated gene loci, it is very likely that the elevated plasma ET-1 concentrations in hypertensive patients are secondary to hypertension and may reflect endothelial cell damage.}, language = {en} } @article{WeckWitthoeft2017, author = {Weck, Florian and Witth{\"o}ft, Michael}, title = {Context effects in the evaluation of bodily symptoms}, series = {Journal of experimental psychopathology}, volume = {8}, journal = {Journal of experimental psychopathology}, publisher = {Sage Publishing}, address = {London}, issn = {2043-8087}, doi = {10.5127/jep.054216}, pages = {241 -- 251}, year = {2017}, abstract = {The illness-related evaluation of bodily symptoms is considered to be an important maintaining factor in somatoform disorders. However, little is known about context variables that could influence this evaluation process. In the current study, participants completed three versions of the Health Norms Sorting Task (HNST) and evaluated bodily symptoms in different contexts (i.e., different evaluation perspectives and time frames of evaluation). Additionally, the three HNST versions were presented in different orders. Bodily symptoms were evaluated more often as a sign of illness when a specific time frame (i.e., one week) was given. However, this context effect was only large when participants had previously evaluated symptoms existing without a concrete duration. Thus, previously completed symptom evaluations appear to represent an important frame of reference in terms of a cue that makes specific context variables salient. The results further suggested that these cueing effects might be less relevant for participants with elevated somatic symptom reports.}, language = {en} } @article{OmotoshoEmuoyibofarheMeinel2017, author = {Omotosho, Adebayo and Emuoyibofarhe, Justice and Meinel, Christoph}, title = {Securing e-prescription from medical identity theft using steganography and antiphishing techniques}, series = {Journal of applied security research}, volume = {12}, journal = {Journal of applied security research}, publisher = {Routledge, Taylor \& Francis Group}, address = {Philadelphia}, issn = {1936-1610}, doi = {10.1080/19361610.2017.1315788}, pages = {447 -- 461}, year = {2017}, abstract = {Drug prescription is among the health care process that usually makes references to the patients' medical and insurance information among other personal data, because this information is very vital and delicate, it should be adequately protected from identity thieves. This article aims at securing Electronic Prescription (EP) in order to minimize patient's data theft and foster patients' trust of EP system. This paper presents a steganography and antiphishing technique for preventing medical identity theft in EP. The proposed EP system design focused on the security features in the prescriber and dispensers' modules of EP by ensuring the prescriber sends the prescription of the patient in a safe manner and to the right dispenser without the interference of fake third parties. Hexadecimal steganography image system is used to cover and secure the sent prescription details. Malicious electronic dispensing system is prevented through an authentication technique where a dispenser uses a captcha together with a one-time password, and the web server encrypted token for prescriber's device authentication. The steganography system is evaluated using Peak Signal to Noise Ratio (PSNR). The system implementation results showed that steganography and antiphishing techniques are capable of providing a secure EP systems.}, language = {en} } @article{WobbeRenardMueller2017, author = {Wobbe, Theresa and Renard, L{\´e}a and M{\"u}ller, Katja}, title = {Nationale und globale Deutungsmodelle des Geschlechts im arbeitsstatistischen sowie arbeitsrechtlichen Klassifikationssystem}, series = {Soziale Welt : SozW ; Zeitschrift f{\"u}r sozialwissenschaftliche Forschung und Praxis}, volume = {68}, journal = {Soziale Welt : SozW ; Zeitschrift f{\"u}r sozialwissenschaftliche Forschung und Praxis}, publisher = {Nomos-Verl.-Ges.}, address = {Baden-Baden}, issn = {0038-6073}, doi = {10.5771/0038-6073-2017-1-63}, pages = {63 -- 85}, year = {2017}, abstract = {Dieser Beitrag besch{\"a}ftigt sich mit der Frage, welche Relevanz arbeitsstatis-tische und -rechtliche Kategorisierungen im Zeitraum von 1880 bis 1992 f{\"u}r den Wandel der Deu-tungsmodelle des Geschlechts haben. Aus vergleichstheoretischer stellt die Durchsetzung desmodernen Konzepts der Erwerbsarbeit um 1900 im nationalen Kontext und dessen Ver{\"a}nderung aufglobaler Ebene ein spezifisches Ordnungsverfahren dar, das im Mittelpunkt dieses Aufsatzes steht.Auf der Grundlage von zwei Mikrostudien zur Klassifizierung und Reklassifizierung der „Mithel-fenden Familienangeh{\"o}rigen" und des „Nachtarbeitsverbots" wird zum einen die Globalisierung derErwerbsarbeit als Beobachtungsschema, zum anderen der Wandel des Deutungsmodells derGeschlechterdifferenz im Zuge transnationaler Vergleichsverfahren erforscht. In dem Beitrag wirddie Auffassung vertreten, dass der Vergleich einen Globalisierungsmechanismus in der Weltgesell-schaft darstellt.}, language = {de} } @article{MusalekKokstejnPapezetal.2017, author = {Musalek, Martin and Kokstejn, Jakub and Papez, Pavel and Scheffler, Christiane and Mumm, Rebekka and Czernitzki, Anna-Franziska and Koziel, Slawomir}, title = {Impact of normal weight obesity on fundamental motor skills in pre-school children aged 3 to 6 years}, series = {Journal of biological and clinical anthropology : Anthropologischer Anzeiger ; Mitteilungsorgan der Gesellschaft f{\"u}r Anthropologie}, volume = {74}, journal = {Journal of biological and clinical anthropology : Anthropologischer Anzeiger ; Mitteilungsorgan der Gesellschaft f{\"u}r Anthropologie}, publisher = {Schweizerbart}, address = {Stuttgart}, issn = {0003-5548}, doi = {10.1127/anthranz/2017/0752}, pages = {203 -- 212}, year = {2017}, abstract = {Normal weight obesity is defined as having excessive body fat, but normal BMI. Even though previous research revealed that excessive body fat in children inhibited their physical activity and decreased motor performance, there has been only little evidence about motor performance of normal weight obese children. This study aims to establish whether normal weight obese pre-school children aged 3-6 years will have a significantly worse level of fundamental motor skills compared to normal weight non-obese counterparts. The research sample consisted of 152 pre-schoolers selected from a specific district of Prague, the Czech Republic. According to values from four skinfolds: triceps, subscapula, suprailiaca, calf, and BMI three categories of children aged 3-6 years were determined: A) normal weight obese n = 51; B) normal weight non-obese n = 52; C) overweight and obese n = 49. The Movement Assessment Battery for Children (MABC-2) was used for the assessment of fundamental motor skills. Normal weight obese children had significantly higher amount of adipose tissue p < 0.001 than normal weight non-obese children but the same average BMI. Moreover, normal weight obese children did not have significantly less amount of subcutaneous fat on triceps and calf compared to their overweight and obese peers. In majority of MABC-2 tests, normal weight obese pre-schoolers showed the poorest performance. Moreover, normal weight obese children had significantly worse total standard score = 38.82 compared to normal weight non-obese peers = 52.27; p < 0.05. In addition, normal weight obese children had a more than three times higher frequency OR = 3.69 CI95\% (1.10; 12.35) of severe motor deficit performance <= 5th centile of the MABC-2 norm. These findings are strongly alarming since indices like BMI are not able to identify normal weight obese individual. We recommend verifying real portion of normal weight obese children as they are probably in higher risk of health and motor problems than overweight and obese population due to their low lean mass.}, language = {en} } @article{MeraTarchanov2017, author = {Mera, Azal Jaafar Musa and Tarchanov, Nikolaj Nikolaevič}, title = {The Neumann Problem after Spencer}, series = {Žurnal Sibirskogo Federalʹnogo Universiteta = Journal of Siberian Federal University : Matematika i fizika = Mathematics \& physics}, volume = {10}, journal = {Žurnal Sibirskogo Federalʹnogo Universiteta = Journal of Siberian Federal University : Matematika i fizika = Mathematics \& physics}, publisher = {Sibirskij Federalʹnyj Universitet}, address = {Krasnojarsk}, issn = {1997-1397}, doi = {10.17516/1997-1397-2017-10-4-474-493}, pages = {474 -- 493}, year = {2017}, abstract = {When trying to extend the Hodge theory for elliptic complexes on compact closed manifolds to the case of compact manifolds with boundary one is led to a boundary value problem for the Laplacian of the complex which is usually referred to as Neumann problem. We study the Neumann problem for a larger class of sequences of differential operators on a compact manifold with boundary. These are sequences of small curvature, i.e., bearing the property that the composition of any two neighbouring operators has order less than two.}, language = {en} } @article{MummCzernitzkiBentsetal.2017, author = {Mumm, Rebekka and Czernitzki, Anna-Franziska and Bents, Dominik and Musalek, Martin}, title = {Socioeconomic situation and growth in infants and juveniles}, series = {Anthropologischer Anzeiger : journal of biological and clinical anthropology ; Mitteilungsorgan der Gesellschaft f{\"u}r Anthropologie}, volume = {74}, journal = {Anthropologischer Anzeiger : journal of biological and clinical anthropology ; Mitteilungsorgan der Gesellschaft f{\"u}r Anthropologie}, publisher = {Schweizerbart}, address = {Stuttgart}, issn = {0003-5548}, doi = {10.1127/anthranz/2017/0706}, pages = {101 -- 107}, year = {2017}, abstract = {Background: Physical growth of children and adolescents depends on the interaction of genetic and environmental factors e.g. diet and living conditions. Aim: We aim to discuss the influence of socioeconomic situation, using income inequality and GDP per capita as indicators, on body height, body weight and the variability of height and weight in infants and juveniles. Material and methods: We re-analyzed data from 439 growth studies on height and weight published during the last 35 years. We added year-and country-matched GDP per capita (in current US\$) and the Gini coefficient for each study. The data were divided into two age groups: infants (age 2) and juveniles (age 7). We used Pearson correlation and principal component analysis to investigate the data. Results: Gini coefficient negatively correlated with body height and body weight in infants and juveniles. GDP per capita showed a positive correlation with height and weight in both age groups. In infants the standard deviation of height increases with increasing Gini coefficient. The opposite is true for juveniles. A correlation of weight variability and socioeconomic indicators is absent in infants. In juveniles the variability of weight increases with declining Gini coefficient and increasing logGDP per capita. Discussion: Poverty and income inequality are generally associated with poor growth in height and weight. The analysis of the within-population height and weight variations however, shows that the associations between wealth, income, and anthropometric parameters are very complex and cannot be explained by common wisdom. They point towards an independent regulation of height and weight.}, language = {en} } @article{MorgnerBennemannCywińskietal.2017, author = {Morgner, Frank and Bennemann, Mark and Cywiński, Piotr J. and Kollosche, Matthias and G{\´o}rski, Krzysztof and Pietraszkiewicz, Marek and Geßner, Andr{\´e} and L{\"o}hmannsr{\"o}ben, Hans-Gerd}, title = {Elastic FRET sensors for contactless pressure measurement}, series = {RSC Advances : an international journal to further the chemical sciences}, volume = {7}, journal = {RSC Advances : an international journal to further the chemical sciences}, publisher = {RSC Publishing}, address = {Cambridge}, issn = {2046-2069}, doi = {10.1039/c7ra06379b}, pages = {50578 -- 50583}, year = {2017}, abstract = {Contactless pressure monitoring based on Forster resonance energy transfer between donor/acceptor pairs immobilized within elastomers is demonstrated. The donor/acceptor energy transfer is employed by dispersing terbium(III) tris[(2-hydroxybenzoyl)-2-aminoethyl] amine complex (LLC, donor) and CdSe/ZnS quantum dots (QD655, acceptor) in styrene-ethylene/buthylene-styrene (SEBS) and poly(dimethylsiloxane) (PDMS). The continuous monitoring of QD luminescence showed a reversible intensity change as the pressure signal is alternated between two stable states indicating a pressure sensitivity of 6350 cps kPa(-1). Time-resolved measurements show the pressure impact on the FRET signal due to an increase of decay time (270 ms up to 420 ms) for the donor signal and parallel drop of decay time (170 mu s to 155 mu s) for the acceptor signal as the net pressure applied. The LLC/QD655 sensors enable a contactless readout as well as space resolved monitoring to enable miniaturization towards smaller integrated stretchable opto-electronics. Elastic FRET sensors can potentially lead to developing profitable analysis systems capable to outdo conventional wired electronic systems (inductive, capacitive, ultrasonic and photoelectric sensors) especially for point-of-care diagnostics, biological monitoring required for wearable electronics.}, language = {en} } @article{Hinz2017, author = {Hinz, Carsten}, title = {Bildung f{\"u}r nachhaltige Entwicklung}, series = {Technische Bildung und berufliche Orientierung im Wandel- R{\"u}ckblick, Einblicke, Ausblicke (Sitzungsberichte Leibniz-Soziet{\"a}t der Wissenschaften)}, volume = {133/134}, journal = {Technische Bildung und berufliche Orientierung im Wandel- R{\"u}ckblick, Einblicke, Ausblicke (Sitzungsberichte Leibniz-Soziet{\"a}t der Wissenschaften)}, editor = {Banse, Gerhard and Apelojg, Benjamin}, publisher = {Trafo}, address = {Berlin}, pages = {167 -- 175}, year = {2017}, language = {de} } @misc{RenzShamsMeinel2017, author = {Renz, Jan and Shams, Ahmed and Meinel, Christoph}, title = {Offline-Enabled Web-based E-Learning for Improved User Experience in Africa}, series = {2017 IEEE Africon}, journal = {2017 IEEE Africon}, publisher = {IEEE}, address = {New York}, isbn = {978-1-5386-2775-4}, issn = {2153-0025}, doi = {10.1109/AFRCON.2017.8095574}, pages = {736 -- 742}, year = {2017}, abstract = {Web-based E-Learning uses Internet technologies and digital media to deliver education content to learners. Many universities in recent years apply their capacity in producing Massive Open Online Courses (MOOCs). They have been offering MOOCs with an expectation of rendering a comprehensive online apprenticeship. Typically, an online content delivery process requires an Internet connection. However, access to the broadband has never been a readily available resource in many regions. In Africa, poor and no networks are yet predominantly experienced by Internet users, frequently causing offline each moment a digital device disconnect from a network. As a result, a learning process is always disrupted, delayed and terminated in such regions. This paper raises the concern of E-Learning in poor and low bandwidths, in fact, it highlights the needs for an Offline-Enabled mode. The paper also explores technical approaches beamed to enhance the user experience inWeb-based E-Learning, particular in Africa.}, language = {en} } @article{HornickBachCrawfurdetal.2017, author = {Hornick, Thomas and Bach, Lennart T. and Crawfurd, Katharine J. and Spilling, Kristian and Achterberg, Eric P. and Woodhouse, Jason Nicholas and Schulz, Kai G. and Brussaard, Corina P. D. and Riebesell, Ulf and Grossart, Hans-Peter}, title = {Ocean acidification impacts bacteria-phytoplankton coupling at low-nutrient conditions}, series = {Biogeosciences}, volume = {14}, journal = {Biogeosciences}, number = {1}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1726-4170}, doi = {10.5194/bg-14-1-2017}, pages = {1 -- 15}, year = {2017}, abstract = {The oceans absorb about a quarter of the annually produced anthropogenic atmospheric carbon dioxide (CO2), resulting in a decrease in surface water pH, a process termed ocean acidification (OA). Surprisingly little is known about how OA affects the physiology of heterotrophic bacteria or the coupling of heterotrophic bacteria to phytoplankton when nutrients are limited. Previous experiments were, for the most part, undertaken during productive phases or following nutrient additions designed to stimulate algal blooms. Therefore, we performed an in situ large-volume mesocosm (similar to 55 m(3)) experiment in the Baltic Sea by simulating different fugacities of CO2 (fCO(2)) extending from present to future conditions. The study was conducted in July-August after the nominal spring bloom, in order to maintain low-nutrient conditions throughout the experiment. This resulted in phytoplankton communities dominated by small-sized functional groups (picophytoplankton). There was no consistent fCO(2)-induced effect on bacterial protein production (BPP), cell-specific BPP (csBPP) or biovolumes (BVs) of either free-living (FL) or particle-associated (PA) heterotrophic bacteria, when considered as individual components (univariate analyses). Permutational Multivariate Analysis of Variance (PERMANOVA) revealed a significant effect of the fCO(2) treatment on entire assemblages of dissolved and particulate nutrients, metabolic parameters and the bacteria-phytoplankton community. However, distance-based linear modelling only identified fCO(2) as a factor explaining the variability observed amongst the microbial community composition, but not for explaining variability within the metabolic parameters. This suggests that fCO(2) impacts on microbial metabolic parameters occurred indirectly through varying physicochemical parameters and microbial species composition. Cluster analyses examining the co-occurrence of different functional groups of bacteria and phytoplankton further revealed a separation of the four fCO(2)-treated mesocosms from both control mesocosms, indicating that complex trophic interactions might be altered in a future acidified ocean. Possible consequences for nutrient cycling and carbon export are still largely unknown, in particular in a nutrient-limited ocean.}, language = {en} } @article{RaetzelWilkensMenzel2017, author = {R{\"a}tzel, Dennis and Wilkens, Martin and Menzel, Ralf}, title = {Effect of polarization entanglement in photon-photon scattering}, series = {Physical review : A, Atomic, molecular, and optical physics}, volume = {95}, journal = {Physical review : A, Atomic, molecular, and optical physics}, number = {1}, publisher = {American Physical Society}, address = {College Park}, issn = {2469-9926}, doi = {10.1103/PhysRevA.95.012101}, pages = {6}, year = {2017}, abstract = {It is found that the differential cross section of photon-photon scattering is a function of the degree of polarization entanglement of the two-photon state. A reduced general expression for the differential cross section of photon-photon scattering is derived by applying simple symmetry arguments. An explicit expression is obtained for the example of photon-photon scattering due to virtual electron-positron pairs in quantum electrodynamics. It is shown how the effect in this explicit example can be explained as an effect of quantum interference and that it fits with the idea of distance-dependent forces.}, language = {en} } @article{MakhmudovTarchanov2017, author = {Makhmudov, O. I. and Tarchanov, Nikolaj Nikolaevič}, title = {The first mixed problem for the nonstationary Lam{\´e} system}, series = {The Rocky Mountain journal of mathematics}, volume = {47}, journal = {The Rocky Mountain journal of mathematics}, number = {8}, publisher = {Rocky Mountain Mathematics Consortium}, address = {Tempe}, issn = {0035-7596}, doi = {10.1216/RMJ-2017-47-8-2731}, pages = {2731 -- 2756}, year = {2017}, abstract = {We find an adequate interpretation of the stationary Lam'{e} operator within the framework of elliptic complexes and study the first mixed problem for the nonstationary Lam'{e} system.}, language = {en} } @article{MuwongeSchiefeleSsenyongaetal.2017, author = {Muwonge, Charles Magoba and Schiefele, Ulrich and Ssenyonga, Joseph and Kibedi, Henry}, title = {Determinants of persistence among science teacher-trainees}, series = {ournal of science teacher education : official journal of the Association for Science Teacher Education (ASTE)}, volume = {28}, journal = {ournal of science teacher education : official journal of the Association for Science Teacher Education (ASTE)}, publisher = {Taylor \& Francis}, address = {Abingdon}, issn = {1046-560X}, doi = {10.1080/1046560X.2017.1379860}, pages = {522 -- 548}, year = {2017}, abstract = {Grounded in the expectancy-value and hope theories, the present study was conducted to examine the extent to which self-efficacy, task value, and academic hope predict persistence among science teacher-trainees in Uganda. The sample consisted of 278 undergrad- uate science teacher-trainees selected from a large public university in northern Uganda. Data were collected using several scales from the modified Motivated Strategies for Learning Questionnaire, Academic Hope Scale, and College Persistence Questionnaire and analyzed using structural equation modeling. Task value and aca- demic hope significantly predicted students' persistence. Academic hope made a greater contribution to students' persistence compared to task value. The combined effect of task value and academic hope did not make any significant contribution to students' persistence. The study highlights the need to strengthen students' hopeful think- ing and task value in order to increase their chances of completing their studies. Implications of the study findings for educational practice and for the training of science teacher-trainees are elaborated in the article.}, language = {en} } @article{HoffmannSchulzHankeAlbaetal.2017, author = {Hoffmann, Mathias and Schulz-Hanke, Maximilian and Alba, Juana Garcia and Jurisch, Nicole and Hagemann, Ulrike and Sachs, Torsten and Sommer, Michael and Augustin, J{\"u}rgen}, title = {A simple calculation algorithm to separate high-resolution CH4 flux measurements into ebullition- and diffusion-derived components}, series = {Atmospheric measurement techniques : an interactive open access journal of the European Geosciences Union}, volume = {10}, journal = {Atmospheric measurement techniques : an interactive open access journal of the European Geosciences Union}, number = {1}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1867-1381}, doi = {10.5194/amt-10-109-2017}, pages = {109 -- 118}, year = {2017}, abstract = {Processes driving the production, transformation and transport of methane (CH4 / in wetland ecosystems are highly complex. We present a simple calculation algorithm to separate open-water CH4 fluxes measured with automatic chambers into diffusion-and ebullition-derived components. This helps to reveal underlying dynamics, to identify potential environmental drivers and, thus, to calculate reliable CH4 emission estimates. The flux separation is based on identification of ebullition-related sudden concentration changes during single measurements. Therefore, a variable ebullition filter is applied, using the lower and upper quartile and the interquartile range (IQR). Automation of data processing is achieved by using an established R script, adjusted for the purpose of CH4 flux calculation. The algorithm was validated by performing a laboratory experiment and tested using flux measurement data (July to September 2013) from a former fen grassland site, which converted into a shallow lake as a result of rewetting. Ebullition and diffusion contributed equally (46 and 55 \%) to total CH4 emissions, which is comparable to ratios given in the literature. Moreover, the separation algorithm revealed a concealed shift in the diurnal trend of diffusive fluxes throughout the measurement period. The water temperature gradient was identified as one of the major drivers of diffusive CH4 emissions, whereas no significant driver was found in the case of erratic CH4 ebullition events.}, language = {en} } @article{ShainyanBelyakovSigolaevetal.2017, author = {Shainyan, Bagrat A. and Belyakov, Alexander V. and Sigolaev, Yurii F. and Khramov, Alexander N. and Kleinpeter, Erich}, title = {Molecular Structure and Conformational Analysis of 1-Phenyl-1-X-1-Silacyclohexanes (X = F, Cl) by Electron Diffraction, Low-Temperature NMR, and Quantum Chemical Calculations}, series = {The journal of organic chemistry}, volume = {82}, journal = {The journal of organic chemistry}, number = {1}, publisher = {American Chemical Society}, address = {Washington}, issn = {0022-3263}, doi = {10.1021/acs.joc.6b02538}, pages = {461 -- 470}, year = {2017}, abstract = {The molecular structure and conformational preferences of 1-phenyl-1-X-1-silacyclohexanes C5H10Si(Ph,X) (X = F (3), Cl (4)) were studied by gas-phase electron diffraction, low-temperature NMR spectroscopy, and high-level quantum chemical calculations. In the gas phase only three (3) and two (4) stable conformers differing in the axial or equatorial location of the phenyl group and the angle of rotation about the Si-C-ph bond (axi and axo denote the Ph group lying in or out of the X-Si-C-ph plane) contribute to the equilibrium. In 3 the ratio Ph-eq:Ph-axo:Ph-axi is 40(12):55(24):5 and 64:20:16 by experiment and theory, respectively. In 4 the ratio Ph-eq:Ph-axo is 79(15):21(15) and 71:29 by experiment and theory (M06-2X calculations), respectively. The gas-phase electron diffraction parameters are in good agreement with those obtained from theory at the M06-2X/aug-ccPVTZ and MP2/aug-cc-pVTZ levels. Unlike the case for M06-2X, MP2 calculations indicate that 3-Ph-eq conformer lies 0.5 kcal/mol higher than the 3-Ph-axo, conformer. As follows from QTAIM analysis, the phenyl group is more stable when it is located in the axial position but produces destabilization of the silacyclohexane ring: By low temperature NMR spectroscopy the six-membered ring interconversion could be frozen, at 103 K and the present conformational equilibria of 3 and 4 could be determined. The ratio of the conformers is 3-Ph-eq:3-Ph-ax = (75-77):(23-25) and 4-Ph-eq:4-Ph-ax = 82:18.}, language = {en} } @article{MartinezGarzonKwiatekBohnhoffetal.2017, author = {Mart{\´i}nez-Garz{\´o}n, Patricia and Kwiatek, Grzegorz and Bohnhoff, Marco and Dresen, Georg}, title = {Volumetric components in the earthquake source related to fluid injection and stress state}, series = {Geophysical research letters}, volume = {44}, journal = {Geophysical research letters}, number = {2}, publisher = {American Geophysical Union}, address = {Washington}, issn = {0094-8276}, doi = {10.1002/2016GL071963}, pages = {800 -- 809}, year = {2017}, abstract = {We investigate source processes of fluid-induced seismicity from The Geysers geothermal reservoir in California to determine their relation with hydraulic operations and improve the corresponding seismic hazard estimates. Analysis of 869 well-constrained full moment tensors (M-w 0.8-3.5) reveals significant non-double-couple components (>25\%) for about 65\% of the events. Volumetric deformation is governed by cumulative injection rates with larger non-double-couple components observed near the wells and during high injection periods. Source mechanisms are magnitude dependent and vary significantly between faulting regimes. Normal faulting events (M-w<2) reveal substantial volumetric components indicating dilatancy in contrast to strike-slip events that have a dominant double-couple source. Volumetric components indicating closure of cracks in the source region are mostly found for reverse faulting events with M-w>2.5. Our results imply that source processes and magnitudes of fluid-induced seismic events are strongly affected by the hydraulic operations, the reservoir stress state, and the faulting regime.}, language = {en} } @article{LecourieuxKappelPierietal.2017, author = {Lecourieux, Fatma and Kappel, Christian and Pieri, Philippe and Charon, Justine and Pillet, Jeremy and Hilbert, Ghislaine and Renaud, Christel and Gomes, Eric and Delrot, Serge and Lecourieux, David}, title = {Dissecting the Biochemical and Transcriptomic Effects of a Locally Applied Heat Treatment on Developing Cabernet Sauvignon Grape Berries}, series = {Frontiers in plant science}, volume = {8}, journal = {Frontiers in plant science}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-462X}, doi = {10.3389/fpls.2017.00053}, pages = {23}, year = {2017}, abstract = {Reproductive development of grapevine and berry composition are both strongly influenced by temperature. To date, the molecular mechanisms involved in grapevine berries response to high temperatures are poorly understood. Unlike recent data that addressed the effects on berry development of elevated temperatures applied at the whole plant level, the present work particularly focuses on the fruit responses triggered by direct exposure to heat treatment (HT). In the context of climate change, this work focusing on temperature effect at the microclimate level is of particular interest as it can help to better understand the consequences of leaf removal (a common viticultural practice) on berry development. HT (+8 degrees C) was locally applied to clusters from Cabernet Sauvignon fruiting cuttings at three different developmental stages (middle green, veraison and middle ripening). Samples were collected 1, 7, and 14 days after treatment and used for metabolic and transcriptomic analyses. The results showed dramatic and specific biochemical and transcriptomic changes in heat exposed berries, depending on the developmental stage and the stress duration. When applied at the herbaceous stage, HT delayed the onset of veraison. Heating also strongly altered the berry concentration of amino acids and organic acids (e.g., phenylalanine, raminobutyric acid and malate) and decreased the anthocyanin content at maturity. These physiological alterations could be partly explained by the deep remodeling of transcriptome in heated berries. More than 7000 genes were deregulated in at least one of the nine experimental conditions. The most affected processes belong to the categories "stress responses," protein metabolism" and "secondary metabolism," highlighting the intrinsic capacity of grape berries to perceive HT and to build adaptive responses. Additionally, important changes in processes related to "transport," "hormone" and "cell wall" might contribute to the postponing of veraison. Finally, opposite effects depending on heating duration were observed for genes encoding enzymes of the general phenylpropanoid pathway, suggesting that the HI induced decrease in anthocyanin content may result from a combination of transcript abundance and product degradation.}, language = {en} } @article{HildebrandLaschewskyPaechetal.2017, author = {Hildebrand, Viet and Laschewsky, Andre and P{\"a}ch, Michael and M{\"u}ller-Buschbaum, Peter and Papadakis, Christine M.}, title = {Effect of the zwitterion structure on the thermo-responsive behaviour of poly(sulfobetaine methacrylates)}, series = {Polymer Chemistry}, volume = {8}, journal = {Polymer Chemistry}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1759-9954}, doi = {10.1039/c6py01220e}, pages = {310 -- 322}, year = {2017}, abstract = {A series of new sulfobetaine methacrylates, including nitrogen-containing saturated heterocycles, was synthesised by systematically varying the substituents of the zwitterionic group. Radical polymerisation via the RAFT (reversible addition-fragmentation chain transfer) method in trifluoroethanol proceeded smoothly and was well controlled, yielding polymers with predictable molar masses. Molar mass analysis and control of the end-group fidelity were facilitated by end-group labeling with a fluorescent dye. The polymers showed distinct thermo-responsive behaviour of the UCST (upper critical solution temperature) type in an aqueous solution, which could not be simply correlated to their molecular structure via an incremental analysis of the hydrophilic and hydrophobic elements incorporated within them. Increasing the spacer length separating the ammonium and the sulfonate groups of the zwitterion moiety from three to four carbons increased the phase transition temperatures markedly, whereas increasing the length of the spacer separating the ammonium group and the carboxylate ester group on the backbone from two to three carbons provoked the opposite effect. Moreover, the phase transition temperatures of the analogous polyzwitterions decreased in the order dimethylammonio > morpholinio > piperidinio alkanesulfonates. In addition to the basic effect of the polymers' precise molecular structure, the concentration and the molar mass dependence of the phase transition temperatures were studied. Furthermore, we investigated the influence of added low molar mass salts on the aqueous-phase behaviour for sodium chloride and sodium bromide as well as sodium and ammonium sulfate. The strong effects evolved in a complex way with the salt concentration. The strength of these effects depended on the nature of the anion added, increasing in the order sulfate < chloride < bromide, thus following the empirical Hofmeister series. In contrast, no significant differences were observed when changing the cation, i.e. when adding sodium or ammonium sulfate.}, language = {en} } @misc{HoogenboomSchlaad2017, author = {Hoogenboom, Richard and Schlaad, Helmut}, title = {Thermoresponsive poly(2-oxazoline)s, polypeptoids, and polypeptides}, series = {Polymer Chemistry}, volume = {8}, journal = {Polymer Chemistry}, number = {1}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1759-9954}, doi = {10.1039/c6py01320a}, pages = {24 -- 40}, year = {2017}, abstract = {This review covers the recent advances in the emerging field of thermoresponsive polyamides or polymeric amides, i.e., poly(2-oxazoline)s, polypeptoids, and polypeptides, with a specific focus on structure-thermoresponsive property relationships, self-assembly, and applications.}, language = {en} } @article{SchuermannBald2017, author = {Sch{\"u}rmann, Robin Mathis and Bald, Ilko}, title = {Real-time monitoring of plasmon induced dissociative electron transfer to the potential DNA radiosensitizer 8-bromoadenine}, series = {Nanoscale}, volume = {9}, journal = {Nanoscale}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {2040-3364}, doi = {10.1039/c6nr08695k}, pages = {1951 -- 1955}, year = {2017}, abstract = {The excitation of localized surface plasmons in noble metal nanoparticles (NPs) results in different nanoscale effects such as electric field enhancement, the generation of hot electrons and a temperature increase close to the NP surface. These effects are typically exploited in diverse fields such as surface-enhanced Raman scattering (SERS), NP catalysis and photothermal therapy (PTT). Halogenated nucleobases are applied as radiosensitizers in conventional radiation cancer therapy due to their high reactivity towards secondary electrons. Here, we use SERS to study the transformation of 8-bromoadenine ((8Br)A) into adenine on the surface of Au and AgNPs upon irradiation with a low-power continuous wave laser at 532, 633 and 785 nm, respectively. The dissociation of (8Br)A is ascribed to a hot-electron transfer reaction and the underlying kinetics are carefully explored. The reaction proceeds within seconds or even milliseconds. Similar dissociation reactions might also occur with other electrophilic molecules, which must be considered in the interpretation of respective SERS spectra. Furthermore, we suggest that hot-electron transfer induced dissociation of radiosensitizers such as (8Br)A can be applied in the future in PTT to enhance the damage of tumor tissue upon irradiation.}, language = {en} } @article{GereckeEdlichGiulbudagianetal.2017, author = {Gerecke, Christian and Edlich, Alexander and Giulbudagian, Michael and Schumacher, Fabian and Zhang, Nan and Said, Andre and Yealland, Guy and Lohan, Silke B. and Neumann, Falko and Meinke, Martina C. and Ma, Nan and Calderon, Marcelo and Hedtrich, Sarah and Schaefer-Korting, Monika and Kleuser, Burkhard}, title = {Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes}, series = {Nanotoxicology}, volume = {11}, journal = {Nanotoxicology}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {1743-5390}, doi = {10.1080/17435390.2017.1292371}, pages = {267 -- 277}, year = {2017}, abstract = {Novel nanogels that possess the capacity to change their physico-chemical properties in response to external stimuli are promising drug-delivery candidates for the treatment of severe skin diseases. As thermoresponsive nanogels (tNGs) are capable of enhancing penetration through biological barriers such as the stratum corneum and are taken up by keratinocytes of human skin, potential adverse consequences of their exposure must be elucidated. In this study, tNGs were synthesized from dendritic polyglycerol (dPG) and two thermoresponsive polymers. tNG_dPG_tPG are the combination of dPG with poly(glycidyl methyl ether-co-ethyl glycidyl ether) (p(GME-co-EGE)) and tNG_dPG_pNIPAM the one with poly(N-isopropylacrylamide) (pNIPAM). Both thermoresponsive nanogels are able to incorporate high amounts of dexamethasone and tacrolimus, drugs used in the treatment of severe skin diseases. Cellular uptake, intracellular localization and the toxicological properties of the tNGs were comprehensively characterized in primary normal human keratinocytes (NHK) and in spontaneously transformed aneuploid immortal keratinocyte cell line from adult human skin (HaCaT). Laser scanning confocal microscopy revealed fluorescently labeled tNGs entered into the cells and localized predominantly within lysosomal compartments. MTT assay, comet assay and carboxy-H2DCFDA assay, demonstrated neither cytotoxic or genotoxic effects, nor any induction of reactive oxygen species of the tNGs in keratinocytes. In addition, both tNGs were devoid of eye irritation potential as shown by bovine corneal opacity and permeability (BCOP) test and red blood cell (RBC) hemolysis assay. Therefore, our study provides evidence that tNGs are locally well tolerated and underlines their potential for cutaneous drug delivery.}, language = {en} }