@article{MassonBambergStrickeretal.2019, author = {Masson, Torsten and Bamberg, Sebastian and Stricker, Michael and Heidenreich, Anna}, title = {"We can help ourselves": does community resilience buffer against the negative impact of flooding on mental health?}, series = {Natural hazards and earth system sciences}, volume = {19}, journal = {Natural hazards and earth system sciences}, number = {11}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1561-8633}, doi = {10.5194/nhess-19-2371-2019}, pages = {2371 -- 2384}, year = {2019}, abstract = {Empirical evidence of the relationship between social support and post-disaster mental health provides support for a general beneficial effect of social support (main-effect model; Wheaton, 1985). From a theoretical perspective, a buffering effect of social support on the negative relationship between disaster-related stress and mental health also seems plausible (stress-buffering model; Wheaton, 1985). Previous studies, however, (a) have paid less attention to the buffering effect of social support and (b) have mainly relied on interpersonal support (but not collective-level support such as community resilience) when investigating this issue. This previous work might have underestimated the effect of support on post-disaster mental health. Building on a sample of residents in Germany recently affected by flooding (N = 118), we show that community resilience to flooding (but not general interpersonal social support) buffered against the negative effects of flooding on post-disaster mental health. The results support the stress-buffering model and call for a more detailed look at the relationship between support and resilience and post-disaster adjustment, including collective-level variables.}, language = {en} } @incollection{Thorau2019, author = {Thorau, Christian}, title = {"What ought to be heard" : touristic listening and the guided ear}, series = {The Oxford handbook of music listening in the 19th and 20th centuries}, booktitle = {The Oxford handbook of music listening in the 19th and 20th centuries}, publisher = {Oxford University Press}, address = {New York}, isbn = {978-0-19-046696-1}, pages = {207 -- 227}, year = {2019}, language = {en} } @article{SchwarzenthalJuangSchachneretal.2019, author = {Schwarzenthal, Miriam Jelena and Juang, Linda P. and Schachner, Maja Katharina and van de Vijver, Fons J. R.}, title = {"When birds of a different feather flock together" - intercultural socialization in adolescents' friendships}, series = {International Journal of Intercultural Relations}, volume = {72}, journal = {International Journal of Intercultural Relations}, publisher = {Elsevier}, address = {Oxford}, issn = {0147-1767}, doi = {10.1016/j.ijintrel.2019.07.001}, pages = {61 -- 75}, year = {2019}, abstract = {We conclude that intercultural friendships are associated with important skills that are needed in increasingly multicultural societies if students experience and discuss cultural variations in these friendships.}, language = {en} } @incollection{Brendel2019, author = {Brendel, Nina}, title = {(How) do students reflect on sustainability?}, series = {Issues in Teaching and Learning of Education for Sustainability}, booktitle = {Issues in Teaching and Learning of Education for Sustainability}, editor = {Chang, Chew-Hung and Kidman, Gillian and Wi, Andy}, publisher = {Routledge}, address = {Abingdon}, isbn = {978-0-429-45043-3}, doi = {10.4324/9780429450433}, pages = {117 -- 126}, year = {2019}, abstract = {The ability to reflect is considered an essential element of Education for Sustainable Development (ESD) and a key competence for learners and educators in ESD (UNECE Strategy for ESD, 2012). In contrast to its high importance, little is known about how reflective thinking can be identified, influenced or increased in the classroom. Therefore, the objective of this study is to address this need by developing an empirical multi-stage model designed to help educators diagnose different levels of reflective thinking and to identify factors that influence students' reflective thinking about sustainability. Based on a 4-8-week project with grade 10 and 11 students studying sustainability, reflective thinking performance using weblogs as reflective journals was analysed. In addition, qualitative semi-structured interviews were conducted with the teachers to comprehend the learning environment and the personal value they assigned to ESD in their geography class. To determine the levels of reflective thinking achieved by the students, the study built on the work of Dewey (1933) and pre-existing multi-stage models of reflective thinking (Bain, Ballantyne, \& Packer, 1999; Chen, Wei, Wu, \& Uden, 2009). Using a qualitative, iterative data analysis, the study adapted the stage models to be applicable in ESD and found great differences in the students' reflection levels. Furthermore, the study identified eight factors that influence students' reflective thinking about sustainability. The outcomes of this study may be valuable for educators in high school and higher education, who seek to diagnose their students' reflective thinking performance and facilitate reflection about sustainability.}, language = {en} } @article{CarlaUhink2019, author = {Carl{\`a}-Uhink, Filippo}, title = {(Re-)Founding Italy: The Social War, Its Aftermath and the Construction of a Roman-Italic Identity in the Roman Republic}, series = {History in Flux: Journal of the Department of History, Faculty of Humanities, Juraj Dobrila University of Pula}, volume = {1}, journal = {History in Flux: Journal of the Department of History, Faculty of Humanities, Juraj Dobrila University of Pula}, number = {1}, doi = {10.32728/flux.2019.1.1}, pages = {3 -- 19}, year = {2019}, abstract = {The Social War (91-88 BCE) is one of the most significant episodes in Roman history: from this war, in which Rome fought against her Italic allies, emerged the elite that would lead the Republic in the last decades of its existence and that would provide the senatorial aristocracy of the early imperial age. The Italic rebels were defeated militarily, yet they achieved their political aims. As such, this war - and its elaboration and memorialization in Roman cultural memory - provides a very interesting case study about how "victory" and "defeat" are constructed discursively after a disruptive war, and how its narration is "functionalized" for a re-foundation of the civic body.}, language = {en} } @article{WiesnerReinholdBarknowitzFlorianetal.2019, author = {Wiesner-Reinhold, Melanie and Barknowitz, Gitte and Florian, Simone and Mewis, Inga and Schumacher, Fabian and Schreiner, Monika and Glatt, Hansruedi}, title = {1-Methoxy-3-indolylmethyl DNA adducts in six tissues, and blood protein adducts, in mice under pak choi diet: time course and persistence}, series = {Archives of toxicology : official journal of EUROTOX}, volume = {93}, journal = {Archives of toxicology : official journal of EUROTOX}, number = {6}, publisher = {Springer}, address = {Heidelberg}, issn = {0340-5761}, doi = {10.1007/s00204-019-02452-3}, pages = {1515 -- 1527}, year = {2019}, abstract = {We previously showed that purified 1-methoxy-3-indolylmethyl (1-MIM) glucosinolate, a secondary plant metabolite in Brassica species, is mutagenic in various in vitro systems and forms DNA and protein adducts in mouse models. In the present study, we administered 1-MIM glucosinolate in a natural matrix to mice, by feeding a diet containing pak choi powder and extract. Groups of animals were killed after 1, 2, 4 and 8 days of pak choi diet, directly or, in the case of the 8-day treatment, after 0, 8 and 16 days of recovery with pak choi-free diet. DNA adducts [N-2-(1-MIM)-dG, N-6-(1-MIM)-dA] in six tissues, as well as protein adducts [tau N-(1-MIM)-His] in serum albumin (SA) and hemoglobin (Hb) were determined using UPLC-MS/MS with isotopically labeled internal standards. None of the samples from the 12 control animals under standard diet contained any 1-MIM adducts. All groups receiving pak choi diet showed DNA adducts in all six tissues (exception: lung of mice treated for a single day) as well as SA and Hb adducts. During the feeding period, all adduct levels continuously increased until day 8 (in the jejunum until day 4). During the 14-day recovery period, N-2-(1-MIM)-dG in liver, kidney, lung, jejunum, cecum and colon decreased to 52, 41, 59, 11, 7 and 2\%, respectively, of the peak level. The time course of N-6-(1-MIM)-dA was similar. Immunohistochemical analyses indicated that cell turnover is a major mechanism of DNA adduct elimination in the intestine. In the same recovery period, protein adducts decreased more rapidly in SA than in Hb, to 0.7 and 37\%, respectively, of the peak level, consistent with the differential turnover of these proteins. In conclusion, the pak choi diet lead to the formation of high levels of adducts in mice. Cell and protein turnover was a major mechanism of adduct elimination, at least in gut and blood.}, language = {en} } @article{ShainyanSuslovaTranDinhPhienetal.2019, author = {Shainyan, Bagrat A. and Suslova, Elena N. and Tran Dinh Phien, and Shlykov, Sergey A. and Heydenreich, Matthias and Kleinpeter, Erich}, title = {1-Methylthio-1-phenyl-1-silacyclohexane: Synthesis, conformational preferences in gas and solution by GED, NMR and theoretical calculations}, series = {Tetrahedron}, volume = {75}, journal = {Tetrahedron}, number = {46}, publisher = {Elsevier}, address = {Oxford}, issn = {0040-4020}, doi = {10.1016/j.tet.2019.130677}, pages = {9}, year = {2019}, abstract = {1-Methylthio-1-phenyl-1-silacyclohexane 1, the first silacyclohexane with the sulfur atom at silicon, was synthesized and its molecular structure and conformational preferences studied by gas-phase electron diffraction (GED) and low temperature C-13 and Si-29 NMR spectroscopy (LT NMR). Quantum-chemical calculations were carried out both for the isolated species and solvate complexes in gas and in polar medium. The predominance of the 1-MeSaxPheq conformer in gas phase (1-Ph-eq :1-Ph-ax = 55:45, Delta G degrees = 0.13 kcal/mol) determined from GED is consistent with that measured in the freon solution by LT NMR (1-Ph-eq:1-Ph-ax = 65:35, Delta G degrees = 0.12 kcal/mol), the experimentally measured ratios being close to that estimated by quantum chemical calculations at both the DFT and MP2 levels of theory. (C) 2019 Elsevier Ltd. All rights reserved.}, language = {en} } @book{Juchler2019, author = {Juchler, Ingo}, title = {1989 in Berlin}, publisher = {bebra}, address = {Berlin}, isbn = {978-3-8148-0236-7}, pages = {128}, year = {2019}, abstract = {Als Hauptstadt der DDR war Ost-Berlin ein wichtiges Zentrum der Friedlichen Revolution von 1989. Ingo Juchler nimmt die Leserinnen und Leser mit zu den zentralen Schaupl{\"a}tzen der Ereignisse, wobei er den Bogen vom 17. Juni 1953 {\"u}ber die Protestbewegung der 1970er Jahre bis hin zu den Demonstrationen im Herbst 1989 und den Ereignissen rund um den Mauerfall schl{\"a}gt. Informative Texte zu den Hintergr{\"u}nden, zahlreiche Abbildungen und eine {\"U}bersichtskarte machen das Buch zu einem anschaulichen Zeitreisef{\"u}hrer in die j{\"u}ngere deutsche Geschichte.}, language = {de} } @book{Juchler2019, author = {Juchler, Ingo}, title = {1989 in Deutschland}, publisher = {bebra}, address = {Berlin}, isbn = {978-3-89809-158-9}, pages = {128}, year = {2019}, abstract = {Kaum ein Ereignis in der zweiten H{\"a}lfte des 20. Jahrhunderts war so bedeutsam wie die Friedliche Revolution von 1989, mit der die Bev{\"o}lkerung der DDR sich vom SED - Regime befreite. Dieses Buch nimmt die Leserinnen und Leser mit zu den zentralen Schaupl{\"a}tzen der Protestbewegung in Deutschland - in Leipzig, Berlin, Dresden, Chemnitz, Plauen, Rostock, Potsdam, Stendal und an vielen anderen Orten. Informative Texte zu den Hintergr{\"u}nden der Ereignisse und umfangreiches Bildmaterial machen das Buch zu einem anschaulichen Zeitreisef{\"u}hrer in die j{\"u}ngere deutsche Geschichte.}, language = {de} } @article{GholamrezaieScheckWenderothBottetal.2019, author = {Gholamrezaie, Ershad and Scheck-Wenderoth, Magdalena and Bott, Judith and Heidbach, Oliver and Strecker, Manfred}, title = {3-D crustal density model of the Sea of Marmara}, series = {Solid Earth}, volume = {10}, journal = {Solid Earth}, publisher = {Copernicus Publ.}, address = {G{\"o}ttingen}, issn = {1869-9510}, doi = {10.5194/se-10-785-2019}, pages = {785 -- 807}, year = {2019}, abstract = {Abstract. The Sea of Marmara, in northwestern Turkey, is a transition zone where the dextral North Anatolian Fault zone (NAFZ) propagates westward from the Anatolian Plate to the Aegean Sea Plate. The area is of interest in the context of seismic hazard of Istanbul, a metropolitan area with about 15 million inhabitants. Geophysical observations indicate that the crust is heterogeneous beneath the Marmara basin, but a detailed characterization of the crustal heterogeneities is still missing. To assess if and how crustal heterogeneities are related to the NAFZ segmentation below the Sea of Marmara, we develop new crustal-scale 3-D density models which integrate geological and seismological data and that are additionally constrained by 3-D gravity modeling. For the latter, we use two different gravity datasets including global satellite data and local marine gravity observation. Considering the two different datasets and the general non-uniqueness in potential field modeling, we suggest three possible "end-member" solutions that are all consistent with the observed gravity field and illustrate the spectrum of possible solutions. These models indicate that the observed gravitational anomalies originate from significant density heterogeneities within the crust. Two layers of sediments, one syn-kinematic and one pre-kinematic with respect to the Sea of Marmara formation are underlain by a heterogeneous crystalline crust. A felsic upper crystalline crust (average density of 2720 kgm⁻³) and an intermediate to mafic lower crystalline crust (average density of 2890 kgm⁻³) appear to be cross-cut by two large, dome-shaped mafic highdensity bodies (density of 2890 to 3150 kgm⁻³) of considerable thickness above a rather uniform lithospheric mantle (3300 kgm⁻³). The spatial correlation between two major bends of the main Marmara fault and the location of the highdensity bodies suggests that the distribution of lithological heterogeneities within the crust controls the rheological behavior along the NAFZ and, consequently, maybe influences fault segmentation and thus the seismic hazard assessment in the region.}, language = {en} } @article{GuillemoteauSimonHulinetal.2019, author = {Guillemoteau, Julien and Simon, Francois-Xavier and Hulin, Guillaume and Dousteyssier, Bertrand and Dacko, Marion and Tronicke, Jens}, title = {3-D imaging of subsurface magnetic permeability/susceptibility with portable frequency domain electromagnetic sensors for near surface exploration}, series = {Geophysical journal international}, volume = {219}, journal = {Geophysical journal international}, number = {3}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0956-540X}, doi = {10.1093/gji/ggz382}, pages = {1773 -- 1785}, year = {2019}, abstract = {The in-phase response collected by portable loop-loop electromagnetic induction (EMI) sensors operating at low and moderate induction numbers (<= 1) is typically used for sensing the magnetic permeability (or susceptibility) of the subsurface. This is due to the fact that the in-phase response contains a small induction fraction and a preponderant induced magnetization fraction. The magnetization fraction follows the magneto-static equations similarly to the magnetic method but with an active magnetic source. The use of an active source offers the possibility to collect data with several loop-loop configurations, which illuminate the subsurface with different sensitivity patterns. Such multiconfiguration soundings thereby allows the imaging of subsurface magnetic permeability/susceptibility variations through an inversion procedure. This method is not affected by the remnant magnetization and theoretically overcomes the classical depth ambiguity generally encountered with passive geomagnetic data. To invert multiconfiguration in-phase data sets, we propose a novel methodology based on a full-grid 3-D multichannel deconvolution (MCD) procedure. This method allows us to invert large data sets (e.g. consisting of more than a hundred thousand of data points) for a dense voxel-based 3-D model of magnetic susceptibility subject to smoothness constraints. In this study, we first present and discuss synthetic examples of our imaging procedure, which aim at simulating realistic conditions. Finally, we demonstrate the applicability of our method to field data collected across an archaeological site in Auvergne (France) to image the foundations of a Gallo-Roman villa built with basalt rock material. Our synthetic and field data examples demonstrate the potential of the proposed inversion procedure offering new and complementary ways to interpret data sets collected with modern EMI instruments.}, language = {en} } @article{GomezGarciaMeessenScheckWenderothetal.2019, author = {Gomez-Garcia, Angela Maria and Meeßen, Christian and Scheck-Wenderoth, Magdalena and Monsalve, Gaspar and Bott, Judith and Bernhardt, Anne and Bernal, Gladys}, title = {3-D Modeling of Vertical Gravity Gradients and the Delimitation of Tectonic Boundaries: The Caribbean Oceanic Domain as a Case Study}, series = {Geochemistry, geophysics, geosystems}, volume = {20}, journal = {Geochemistry, geophysics, geosystems}, number = {11}, publisher = {American Geophysical Union}, address = {Washington}, issn = {1525-2027}, doi = {10.1029/2019GC008340}, pages = {5371 -- 5393}, year = {2019}, abstract = {Geophysical data acquisition in oceanic domains is challenging, implying measurements with low and/or nonhomogeneous spatial resolution. The evolution of satellite gravimetry and altimetry techniques allows testing 3-D density models of the lithosphere, taking advantage of the high spatial resolution and homogeneous coverage of satellites. However, it is not trivial to discretise the source of the gravity field at different depths. Here, we propose a new method for inferring tectonic boundaries at the crustal level. As a novelty, instead of modeling the gravity anomalies and assuming a flat Earth approximation, we model the vertical gravity gradients (VGG) in spherical coordinates, which are especially sensitive to density contrasts in the upper layers of the Earth. To validate the methodology, the complex oceanic domain of the Caribbean region is studied, which includes different crustal domains with a tectonic history since Late Jurassic time. After defining a lithospheric starting model constrained by up-to-date geophysical data sets, we tested several a-priory density distributions and selected the model with the minimum misfits with respect to the VGG calculated from the EIGEN-6C4 data set. Additionally, the density of the crystalline crust was inferred by inverting the VGG field. Our methodology enabled us not only to refine, confirm, and/or propose tectonic boundaries in the study area but also to identify a new anomalous buoyant body, located in the South Lesser Antilles subduction zone, and high-density bodies along the Greater, Lesser, and Leeward Antilles forearcs.}, language = {en} } @article{IbarraLiuMeessenetal.2019, author = {Ibarra, Federico and Liu, Sibiao and Meeßen, Christian and Prezzi, Claudia Beatriz and Bott, Judith and Scheck-Wenderoth, Magdalena and Sobolev, Stephan Vladimir and Strecker, Manfred}, title = {3D data-derived lithospheric structure of the Central Andes and its implications for deformation: Insights from gravity and geodynamic modelling}, series = {Tectonophysics : international journal of geotectonics and the geology and physics of the interior of the earth}, volume = {766}, journal = {Tectonophysics : international journal of geotectonics and the geology and physics of the interior of the earth}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0040-1951}, doi = {10.1016/j.tecto.2019.06.025}, pages = {453 -- 468}, year = {2019}, abstract = {We present a new three-dimensional density model of the Central Andes characterizing the structure and composition of the lithosphere together with a geodynamic simulation subjected to continental intraplate shortening. The principal aim of this study is to assess the link between heterogeneities in the lithosphere and different deformation patterns and styles along the orogen-foreland system of the Central Andes. First, we performed a 3D integration of new geological and geophysical data with previous models through forward modelling of Bouguer anomalies. Subsequently, a geodynamic model was set-up and parametrized from the previously obtained 3D structure and composition. We do not find a unambigous correlation between the resulting density configuration and terrane boundaries proposed by other authors. Our models reproduce the observed Bouguer anomaly and deformation patterns in the foreland. We find that thin-skinned deformation in the Subandean fold-and thrust belt is controlled by a thick sedimentary layer and coeval underthrusting of thin crust of the foreland beneath the thick crust of the Andean Plateau. In the adjacent thick-skinned deformation province of the inverted Cretaceous extensional Santa Barbara System sedimentary strata are much thinner and crustal thickness transitions from greater values in the Andean to a more reduced thickness in the foreland. Our results show that deformation processes occur where the highest gradients of lithospheric strength are present between the orogen and the foreland, thus suggesting a spatial correlation between deformation and lithospheric strength.}, language = {en} } @article{BrellSeglGuanteretal.2019, author = {Brell, Maximilian and Segl, Karl and Guanter, Luis and Bookhagen, Bodo}, title = {3D hyperspectral point cloud generation}, series = {ISPRS journal of photogrammetry and remote sensing : official publication of the International Society for Photogrammetry and Remote Sensing}, volume = {149}, journal = {ISPRS journal of photogrammetry and remote sensing : official publication of the International Society for Photogrammetry and Remote Sensing}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0924-2716}, doi = {10.1016/j.isprsjprs.2019.01.022}, pages = {200 -- 214}, year = {2019}, abstract = {Remote Sensing technologies allow to map biophysical, biochemical, and earth surface parameters of the land surface. Of especial interest for various applications in environmental and urban sciences is the combination of spectral and 3D elevation information. However, those two data streams are provided separately by different instruments, namely airborne laser scanner (ALS) for elevation and a hyperspectral imager (HSI) for high spectral resolution data. The fusion of ALS and HSI data can thus lead to a single data entity consistently featuring rich structural and spectral information. In this study, we present the application of fusing the first pulse return information from ALS data at a sub-decimeter spatial resolution with the lower-spatial resolution hyperspectral information available from the HSI into a hyperspectral point cloud (HSPC). During the processing, a plausible hyperspectral spectrum is assigned to every first-return ALS point. We show that the complementary implementation of spectral and 3D information at the point-cloud scale improves object-based classification and information extraction schemes. This improvements have great potential for numerous land cover mapping and environmental applications.}, language = {en} } @misc{KubatovaHamannKubatetal.2019, author = {Kubatova, Brankica and Hamann, Wolf-Rainer and Kubat, Jiri and Oskinova, Lida}, title = {3D Monte Carlo Radiative Transfer in Inhomogeneous Massive Star Winds}, series = {Radiative signatures from the cosmos}, volume = {519}, journal = {Radiative signatures from the cosmos}, publisher = {Astronomical soc pacific}, address = {San Fransisco}, isbn = {978-1-58381-925-8}, issn = {1050-3390}, pages = {209 -- 212}, year = {2019}, abstract = {Already for decades it has been known that the winds of massive stars are inhomogeneous (i.e. clumped). To properly model observed spectra of massive star winds it is necessary to incorporate the 3-D nature of clumping into radiative transfer calculations. In this paper we present our full 3-D Monte Carlo radiative transfer code for inhomogeneous expanding stellar winds. We use a set of parameters to describe dense as well as the rarefied wind components. At the same time, we account for non-monotonic velocity fields. We show how the 3-D density and velocity wind inhomogeneities strongly affect the resonance line formation. We also show how wind clumping can solve the discrepancy between P v and H alpha mass-loss rate diagnostics.}, language = {en} } @article{Brechenmacher2019, author = {Brechenmacher, Thomas}, title = {70 Jahre Israel}, series = {Historisch-politische Mitteilungen : Archiv f{\"u}r Christlich-Demokratische Politik}, volume = {26}, journal = {Historisch-politische Mitteilungen : Archiv f{\"u}r Christlich-Demokratische Politik}, publisher = {B{\"o}hlau}, address = {Wien}, isbn = {978-3-412-51847-9}, pages = {5 -- 15}, year = {2019}, abstract = {Schon kurz nach dem Zweiten Weltkrieg wurde die These vertreten, die Shoah sei ein wichtiger, wenn nicht gar entscheidender Faktor f{\"u}r die Gr{\"u}ndung des Staates Israel gewesen. Der Essay arbeitet heraus, dass der nationalsozialistische Judenmord sicherlich eine moralisch-legitimatorische Funktion gehabt hat, ein unmittelbarer kausaler Zusammenhang mit der Staatsgr{\"u}ndung aber nicht nachzuweisen ist.}, language = {de} } @article{ZhangBramskiTutusetal.2019, author = {Zhang, Shuhao and Bramski, Julia and Tutus, Murat and Pietruszka, J{\"o}rg and B{\"o}ker, Alexander and Reinicke, Stefan}, title = {A Biocatalytically Active Membrane Obtained from Immobilization of 2-Deoxy-D-ribose-5-phosphate Aldolase on a Porous Support}, series = {ACS applied materials \& interfaces}, volume = {11}, journal = {ACS applied materials \& interfaces}, number = {37}, publisher = {American Chemical Society}, address = {Washington}, issn = {1944-8244}, doi = {10.1021/acsami.9b12029}, pages = {34441 -- 34453}, year = {2019}, abstract = {Aldol reactions play an important role in organic synthesis, as they belong to the class of highly beneficial C-C-linking reactions. Aldol-type reactions can be efficiently and stereoselectively catalyzed by the enzyme 2-deoxy-D-ribose-5-phosphate aldolase (DERA) to gain key intermediates for pharmaceuticals such as atorvastatin. The immobilization of DERA would open the opportunity for a continuous operation mode which gives access to an efficient, large-scale production of respective organic intermediates. In this contribution, we synthesize and utilize DERA/polymer conjugates for the generation and fixation of a DERA bearing thin film on a polymeric membrane support. The conjugation strongly increases the tolerance of the enzyme toward the industrial relevant substrate acetaldehyde while UV-cross-linkable groups along the conjugated polymer chains provide the opportunity for covalent binding to the support. First, we provide a thorough characterization of the conjugates followed by immobilization tests on representative, nonporous cycloolefinic copolymer supports. Finally, immobilization on the target supports constituted of polyacrylonitrile (PAN) membranes is performed, and the resulting enzymatically active membranes are implemented in a simple membrane module setup for the first assessment of biocatalytic performance in the continuous operation mode using the combination hexanal/acetaldehyde as the substrate.}, language = {en} } @article{WuttkeLiLietal.2019, author = {Wuttke, Matthias and Li, Yong and Li, Man and Sieber, Karsten B. and Feitosa, Mary F. and Gorski, Mathias and Tin, Adrienne and Wang, Lihua and Chu, Audrey Y. and Hoppmann, Anselm and Kirsten, Holger and Giri, Ayush and Chai, Jin-Fang and Sveinbjornsson, Gardar and Tayo, Bamidele O. and Nutile, Teresa and Fuchsberger, Christian and Marten, Jonathan and Cocca, Massimiliano and Ghasemi, Sahar and Xu, Yizhe and Horn, Katrin and Noce, Damia and Van der Most, Peter J. and Sedaghat, Sanaz and Yu, Zhi and Akiyama, Masato and Afaq, Saima and Ahluwalia, Tarunveer Singh and Almgren, Peter and Amin, Najaf and Arnlov, Johan and Bakker, Stephan J. L. and Bansal, Nisha and Baptista, Daniela and Bergmann, Sven and Biggs, Mary L. and Biino, Ginevra and Boehnke, Michael and Boerwinkle, Eric and Boissel, Mathilde and B{\"o}ttinger, Erwin and Boutin, Thibaud S. and Brenner, Hermann and Brumat, Marco and Burkhardt, Ralph and Butterworth, Adam S. and Campana, Eric and Campbell, Archie and Campbell, Harry and Canouil, Mickael and Carroll, Robert J. and Catamo, Eulalia and Chambers, John C. and Chee, Miao-Ling and Chee, Miao-Li and Chen, Xu and Cheng, Ching-Yu and Cheng, Yurong and Christensen, Kaare and Cifkova, Renata and Ciullo, Marina and Concas, Maria Pina and Cook, James P. and Coresh, Josef and Corre, Tanguy and Sala, Cinzia Felicita and Cusi, Daniele and Danesh, John and Daw, E. Warwick and De Borst, Martin H. and De Grandi, Alessandro and De Mutsert, Renee and De Vries, Aiko P. J. and Degenhardt, Frauke and Delgado, Graciela and Demirkan, Ayse and Di Angelantonio, Emanuele and Dittrich, Katalin and Divers, Jasmin and Dorajoo, Rajkumar and Eckardt, Kai-Uwe and Ehret, Georg and Elliott, Paul and Endlich, Karlhans and Evans, Michele K. and Felix, Janine F. and Foo, Valencia Hui Xian and Franco, Oscar H. and Franke, Andre and Freedman, Barry I. and Freitag-Wolf, Sandra and Friedlander, Yechiel and Froguel, Philippe and Gansevoort, Ron T. and Gao, He and Gasparini, Paolo and Gaziano, J. Michael and Giedraitis, Vilmantas and Gieger, Christian and Girotto, Giorgia and Giulianini, Franco and Gogele, Martin and Gordon, Scott D. and Gudbjartsson, Daniel F. and Gudnason, Vilmundur and Haller, Toomas and Hamet, Pavel and Harris, Tamara B. and Hartman, Catharina A. and Hayward, Caroline and Hellwege, Jacklyn N. and Heng, Chew-Kiat and Hicks, Andrew A. and Hofer, Edith and Huang, Wei and Hutri-Kahonen, Nina and Hwang, Shih-Jen and Ikram, M. Arfan and Indridason, Olafur S. and Ingelsson, Erik and Ising, Marcus and Jaddoe, Vincent W. V. and Jakobsdottir, Johanna and Jonas, Jost B. and Joshi, Peter K. and Josyula, Navya Shilpa and Jung, Bettina and Kahonen, Mika and Kamatani, Yoichiro and Kammerer, Candace M. and Kanai, Masahiro and Kastarinen, Mika and Kerr, Shona M. and Khor, Chiea-Chuen and Kiess, Wieland and Kleber, Marcus E. and Koenig, Wolfgang and Kooner, Jaspal S. and Korner, Antje and Kovacs, Peter and Kraja, Aldi T. and Krajcoviechova, Alena and Kramer, Holly and Kramer, Bernhard K. and Kronenberg, Florian and Kubo, Michiaki and Kuhnel, Brigitte and Kuokkanen, Mikko and Kuusisto, Johanna and La Bianca, Martina and Laakso, Markku and Lange, Leslie A. and Langefeld, Carl D. and Lee, Jeannette Jen-Mai and Lehne, Benjamin and Lehtimaki, Terho and Lieb, Wolfgang and Lim, Su-Chi and Lind, Lars and Lindgren, Cecilia M. and Liu, Jun and Liu, Jianjun and Loeffler, Markus and Loos, Ruth J. F. and Lucae, Susanne and Lukas, Mary Ann and Lyytikainen, Leo-Pekka and Magi, Reedik and Magnusson, Patrik K. E. and Mahajan, Anubha and Martin, Nicholas G. and Martins, Jade and Marz, Winfried and Mascalzoni, Deborah and Matsuda, Koichi and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Metspalu, Andres and Mikaelsdottir, Evgenia K. and Milaneschi, Yuri and Miliku, Kozeta and Mishra, Pashupati P. and Program, V. A. Million Veteran and Mohlke, Karen L. and Mononen, Nina and Montgomery, Grant W. and Mook-Kanamori, Dennis O. and Mychaleckyj, Josyf C. and Nadkarni, Girish N. and Nalls, Mike A. and Nauck, Matthias and Nikus, Kjell and Ning, Boting and Nolte, Ilja M. and Noordam, Raymond and Olafsson, Isleifur and Oldehinkel, Albertine J. and Orho-Melander, Marju and Ouwehand, Willem H. and Padmanabhan, Sandosh and Palmer, Nicholette D. and Palsson, Runolfur and Penninx, Brenda W. J. H. and Perls, Thomas and Perola, Markus and Pirastu, Mario and Pirastu, Nicola and Pistis, Giorgio and Podgornaia, Anna I. and Polasek, Ozren and Ponte, Belen and Porteous, David J. and Poulain, Tanja and Pramstaller, Peter P. and Preuss, Michael H. and Prins, Bram P. and Province, Michael A. and Rabelink, Ton J. and Raffield, Laura M. and Raitakari, Olli T. and Reilly, Dermot F. and Rettig, Rainer and Rheinberger, Myriam and Rice, Kenneth M. and Ridker, Paul M. and Rivadeneira, Fernando and Rizzi, Federica and Roberts, David J. and Robino, Antonietta and Rossing, Peter and Rudan, Igor and Rueedi, Rico and Ruggiero, Daniela and Ryan, Kathleen A. and Saba, Yasaman and Sabanayagam, Charumathi and Salomaa, Veikko and Salvi, Erika and Saum, Kai-Uwe and Schmidt, Helena and Schmidt, Reinhold and Ben Schottker, and Schulz, Christina-Alexandra and Schupf, Nicole and Shaffer, Christian M. and Shi, Yuan and Smith, Albert V. and Smith, Blair H. and Soranzo, Nicole and Spracklen, Cassandra N. and Strauch, Konstantin and Stringham, Heather M. and Stumvoll, Michael and Svensson, Per O. and Szymczak, Silke and Tai, E-Shyong and Tajuddin, Salman M. and Tan, Nicholas Y. Q. and Taylor, Kent D. and Teren, Andrej and Tham, Yih-Chung and Thiery, Joachim and Thio, Chris H. L. and Thomsen, Hauke and Thorleifsson, Gudmar and Toniolo, Daniela and Tonjes, Anke and Tremblay, Johanne and Tzoulaki, Ioanna and Uitterlinden, Andre G. and Vaccargiu, Simona and Van Dam, Rob M. and Van der Harst, Pim and Van Duijn, Cornelia M. and Edward, Digna R. Velez and Verweij, Niek and Vogelezang, Suzanne and Volker, Uwe and Vollenweider, Peter and Waeber, Gerard and Waldenberger, Melanie and Wallentin, Lars and Wang, Ya Xing and Wang, Chaolong and Waterworth, Dawn M. and Bin Wei, Wen and White, Harvey and Whitfield, John B. and Wild, Sarah H. and Wilson, James F. and Wojczynski, Mary K. and Wong, Charlene and Wong, Tien-Yin and Xu, Liang and Yang, Qiong and Yasuda, Masayuki and Yerges-Armstrong, Laura M. and Zhang, Weihua and Zonderman, Alan B. and Rotter, Jerome I. and Bochud, Murielle and Psaty, Bruce M. and Vitart, Veronique and Wilson, James G. and Dehghan, Abbas and Parsa, Afshin and Chasman, Daniel I. and Ho, Kevin and Morris, Andrew P. and Devuyst, Olivier and Akilesh, Shreeram and Pendergrass, Sarah A. and Sim, Xueling and Boger, Carsten A. and Okada, Yukinori and Edwards, Todd L. and Snieder, Harold and Stefansson, Kari and Hung, Adriana M. and Heid, Iris M. and Scholz, Markus and Teumer, Alexander and Kottgen, Anna and Pattaro, Cristian}, title = {A catalog of genetic loci associated with kidney function from analyses of a million individuals}, series = {Nature genetics}, volume = {51}, journal = {Nature genetics}, number = {6}, publisher = {Nature Publ. Group}, address = {New York}, organization = {Lifelines COHort Study}, issn = {1061-4036}, doi = {10.1038/s41588-019-0407-x}, pages = {957 -- +}, year = {2019}, abstract = {Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.}, language = {en} } @misc{HalfpapSchlosser2019, author = {Halfpap, Stefan and Schlosser, Rainer}, title = {A Comparison of Allocation Algorithms for Partially Replicated Databases}, series = {2019 IEEE 35th International Conference on Data Engineering (ICDE)}, journal = {2019 IEEE 35th International Conference on Data Engineering (ICDE)}, publisher = {IEEE}, address = {New York}, isbn = {978-1-5386-7474-1}, issn = {1084-4627}, doi = {10.1109/ICDE.2019.00226}, pages = {2008 -- 2011}, year = {2019}, abstract = {Increasing demand for analytical processing capabilities can be managed by replication approaches. However, to evenly balance the replicas' workload shares while at the same time minimizing the data replication factor is a highly challenging allocation problem. As optimal solutions are only applicable for small problem instances, effective heuristics are indispensable. In this paper, we test and compare state-of-the-art allocation algorithms for partial replication. By visualizing and exploring their (heuristic) solutions for different benchmark workloads, we are able to derive structural insights and to detect an algorithm's strengths as well as its potential for improvement. Further, our application enables end-to-end evaluations of different allocations to verify their theoretical performance.}, language = {en} } @article{BaroniSchalgeRakovecetal.2019, author = {Baroni, Gabriele and Schalge, Bernd and Rakovec, Oldrich and Kumar, Rohini and Sch{\"u}ler, Lennart and Samaniego, Luis and Simmer, Clemens and Attinger, Sabine}, title = {A Comprehensive Distributed Hydrological Modeling Intercomparison to Support Process Representation and Data Collection Strategies}, series = {Water resources research}, volume = {55}, journal = {Water resources research}, number = {2}, publisher = {American Geophysical Union}, address = {Washington}, issn = {0043-1397}, doi = {10.1029/2018WR023941}, pages = {990 -- 1010}, year = {2019}, abstract = {The improvement of process representations in hydrological models is often only driven by the modelers' knowledge and data availability. We present a comprehensive comparison between two hydrological models of different complexity that is developed to support (1) the understanding of the differences between model structures and (2) the identification of the observations needed for model assessment and improvement. The comparison is conducted on both space and time and by aggregating the outputs at different spatiotemporal scales. In the present study, mHM, a process-based hydrological model, and ParFlow-CLM, an integrated subsurface-surface hydrological model, are used. The models are applied in a mesoscale catchment in Germany. Both models agree in the simulated river discharge at the outlet and the surface soil moisture dynamics, lending their supports for some model applications (drought monitoring). Different model sensitivities are, however, found when comparing evapotranspiration and soil moisture at different soil depths. The analysis supports the need of observations within the catchment for model assessment, but it indicates that different strategies should be considered for the different variables. Evapotranspiration measurements are needed at daily resolution across several locations, while highly resolved spatially distributed observations with lower temporal frequency are required for soil moisture. Finally, the results show the impact of the shallow groundwater system simulated by ParFlow-CLM and the need to account for the related soil moisture redistribution. Our comparison strategy can be applied to other models types and environmental conditions to strengthen the dialog between modelers and experimentalists for improving process representations in Earth system models.}, language = {en} } @article{ChapmanLantOhashietal.2019, author = {Chapman, Eric M. and Lant, Benjamin and Ohashi, Yota and Yu, Bin and Schertzberg, Michael and Go, Christopher and Dogra, Deepika and Koskimaki, Janne and Girard, Romuald and Li, Yan and Fraser, Andrew G. and Awad, Issam A. and Abdelilah-Seyfried, Salim and Gingras, Anne-Claude and Derry, William Brent}, title = {A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis}, series = {Nature Communications}, volume = {10}, journal = {Nature Communications}, publisher = {Nature Publ. Group}, address = {London}, issn = {2041-1723}, doi = {10.1038/s41467-019-09829-z}, pages = {15}, year = {2019}, abstract = {Apoptotic death of cells damaged by genotoxic stress requires regulatory input from surrounding tissues. The C. elegans scaffold protein KRI-1, ortholog of mammalian KRIT1/CCM1, permits DNA damage-induced apoptosis of cells in the germline by an unknown cell non-autonomous mechanism. We reveal that KRI-1 exists in a complex with CCM-2 in the intestine to negatively regulate the ERK-5/MAPK pathway. This allows the KLF-3 transcription factor to facilitate expression of the SLC39 zinc transporter gene zipt-2.3, which functions to sequester zinc in the intestine. Ablation of KRI-1 results in reduced zinc sequestration in the intestine, inhibition of IR-induced MPK-1/ERK1 activation, and apoptosis in the germline. Zinc localization is also perturbed in the vasculature of krit1(-/-) zebrafish, and SLC39 zinc transporters are mis-expressed in Cerebral Cavernous Malformations (CCM) patient tissues. This study provides new insights into the regulation of apoptosis by cross-tissue communication, and suggests a link between zinc localization and CCM disease.}, language = {en} } @article{WinterSchneebergerDungetal.2019, author = {Winter, Benjamin and Schneeberger, Klaus and Dung, N. V. and Huttenlau, M. and Achleitner, S. and St{\"o}tter, J. and Merz, Bruno and Vorogushyn, Sergiy}, title = {A continuous modelling approach for design flood estimation on sub-daily time scale}, series = {Hydrological sciences journal = Journal des sciences hydrologiques}, volume = {64}, journal = {Hydrological sciences journal = Journal des sciences hydrologiques}, number = {5}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0262-6667}, doi = {10.1080/02626667.2019.1593419}, pages = {539 -- 554}, year = {2019}, abstract = {Design flood estimation is an essential part of flood risk assessment. Commonly applied are flood frequency analyses and design storm approaches, while the derived flood frequency using continuous simulation has been getting more attention recently. In this study, a continuous hydrological modelling approach on an hourly time scale, driven by a multi-site weather generator in combination with a -nearest neighbour resampling procedure, based on the method of fragments, is applied. The derived 100-year flood estimates in 16 catchments in Vorarlberg (Austria) are compared to (a) the flood frequency analysis based on observed discharges, and (b) a design storm approach. Besides the peak flows, the corresponding runoff volumes are analysed. The spatial dependence structure of the synthetically generated flood peaks is validated against observations. It can be demonstrated that the continuous modelling approach can achieve plausible results and shows a large variability in runoff volume across the flood events.}, language = {en} } @article{EberliBernoulliVecseietal.2019, author = {Eberli, Gregor P. and Bernoulli, Daniel and Vecsei, Adam and Sekti, Rizky and Grasmueck, Mark and L{\"u}dmann, Thomas and Anselmetti, Flavio S. and Mutti, Maria and Della Porta, Giovanna}, title = {A Cretaceous carbonate delta drift in the Montagna della Maiella, Italy}, series = {Sedimentology : the journal of the International Association of Sedimentologists}, volume = {66}, journal = {Sedimentology : the journal of the International Association of Sedimentologists}, number = {4}, publisher = {Wiley}, address = {Hoboken}, issn = {0037-0746}, doi = {10.1111/sed.12590}, pages = {1266 -- 1301}, year = {2019}, abstract = {The Upper Cretaceous (Campanian-Maastrichtian) bioclastic wedge of the Orfento Formation in the Montagna della Maiella, Italy, is compared to newly discovered contourite drifts in the Maldives. Like the drift deposits in the Maldives, the Orfento Formation fills a channel and builds a Miocene delta-shaped and mounded sedimentary body in the basin that is similar in size to the approximately 350 km(2) large coarse-grained bioclastic Miocene delta drifts in the Maldives. The composition of the bioclastic wedge of the Orfento Formation is also exclusively bioclastic debris sourced from the shallow-water areas and reworked clasts of the Orfento Formation itself. In the near mud-free succession, age-diagnostic fossils are sparse. The depositional textures vary from wackestone to float-rudstone and breccia/conglomerates, but rocks with grainstone and rudstone textures are the most common facies. In the channel, lensoid convex-upward breccias, cross-cutting channelized beds and thick grainstone lobes with abundant scours indicate alternating erosion and deposition from a high-energy current. In the basin, the mounded sedimentary body contains lobes with a divergent progradational geometry. The lobes are built by decametre thick composite megabeds consisting of sigmoidal clinoforms that typically have a channelized topset, a grainy foreset and a fine-grained bottomset with abundant irregular angular clasts. Up to 30 m thick channels filled with intraformational breccias and coarse grainstones pinch out downslope between the megabeds. In the distal portion of the wedge, stacked grainstone beds with foresets and reworked intraclasts document continuous sediment reworking and migration. The bioclastic wedge of the Orfento Formation has been variously interpreted as a succession of sea-level controlled slope deposits, a shoaling shoreface complex, or a carbonate tidal delta. Current-controlled delta drifts in the Maldives, however, offer a new interpretation because of their similarity in architecture and composition. These similarities include: (i) a feeder channel opening into the basin; (ii) an excavation moat at the exit of the channel; (iii) an overall mounded geometry with an apex that is in shallower water depth than the source channel; (iv) progradation of stacked lobes; (v) channels that pinch out in a basinward direction; and (vi) smaller channelized intervals that are arranged in a radial pattern. As a result, the Upper Cretaceous (Campanian-Maastrichtian) bioclastic wedge of the Orfento Formation in the Montagna della Maiella, Italy, is here interpreted as a carbonate delta drift.}, language = {en} } @article{ZechAttingerBellinetal.2019, author = {Zech, Alraune and Attinger, Sabine and Bellin, Alberto and Cvetkovic, Vladimir and Dietrich, Peter and Fiori, Aldo and Teutsch, Georg and Dagan, Gedeon}, title = {A Critical Analysis of Transverse Dispersivity Field Data}, series = {Groundwater : journal of the Association of Ground-Water Scientists and Engineers, a division of the National Ground Water Association}, volume = {57}, journal = {Groundwater : journal of the Association of Ground-Water Scientists and Engineers, a division of the National Ground Water Association}, number = {4}, publisher = {Wiley}, address = {Hoboken}, issn = {0017-467X}, doi = {10.1111/gwat.12838}, pages = {632 -- 639}, year = {2019}, abstract = {Transverse dispersion, or tracer spreading orthogonal to the mean flow direction, which is relevant e.g, for quantifying bio-degradation of contaminant plumes or mixing of reactive solutes, has been studied in the literature less than the longitudinal one. Inferring transverse dispersion coefficients from field experiments is a difficult and error-prone task, requiring a spatial resolution of solute plumes which is not easily achievable in applications. In absence of field data, it is a questionable common practice to set transverse dispersivities as a fraction of the longitudinal one, with the ratio 1/10 being the most prevalent. We collected estimates of field-scale transverse dispersivities from existing publications and explored possible scale relationships as guidance criteria for applications. Our investigation showed that a large number of estimates available in the literature are of low reliability and should be discarded from further analysis. The remaining reliable estimates are formation-specific, span three orders of magnitude and do not show any clear scale-dependence on the plume traveled distance. The ratios with the longitudinal dispersivity are also site specific and vary widely. The reliability of transverse dispersivities depends significantly on the type of field experiment and method of data analysis. In applications where transverse dispersion plays a significant role, inference of transverse dispersivities should be part of site characterization with the transverse dispersivity estimated as an independent parameter rather than related heuristically to longitudinal dispersivity.}, language = {en} } @article{LuetkecosmannFaupelPorstmannetal.2019, author = {Luetkecosmann, Steffi and Faupel, Thomas and Porstmann, Silvia and Porstmann, Tomas and Micheel, Burkhard and Hanack, Katja}, title = {A cross-reactive monoclonal antibody as universal detection antibody in autoantibody diagnostic assays}, series = {Clinica chimica acta}, volume = {499}, journal = {Clinica chimica acta}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0009-8981}, doi = {10.1016/j.cca.2019.09.003}, pages = {87 -- 92}, year = {2019}, abstract = {Diagnostics of Autoimmune Diseases involve screening of patient samples for containing autoantibodies against various antigens. To ensure quality of diagnostic assays a calibrator is needed in each assay system. Different calibrators as recombinant human monoclonal antibodies as well as chimeric antibodies against the autoantigens of interest are described. A less cost-intensive and also more representative possibility covering different targets on the antigens is the utilization of polyclonal sera from other species. Nevertheless, the detection of human autoantibodies as well as the calibration reagent containing antibodies from other species in one assay constitutes a challenge in terms of assay calibration. We therefore developed a cross-reactive monoclonal antibody which binds human as well as rabbit sera with similar affinities in the nanomolar range. We tested our monoclonal antibody S38CD11B12 successfully in the commercial Serazym (R) Anti-Cardiolipin-beta 2-GPI IgG/IgM assay and could thereby prove the eligibility of S38CD11B12 as detection antibody in autoimmune diagnostic assays using rabbit derived sera as reference material.}, language = {en} } @article{DemalHeiseReizetal.2019, author = {Demal, Till Joscha and Heise, Melina and Reiz, Benedikt and Dogra, Deepika and Braenne, Ingrid and Reichenspurner, Hermann and M{\"a}nner, J{\"o}rg and Aherrahrou, Zouhair and Schunkert, Heribert and Erdmann, Jeanette and Abdelilah-Seyfried, Salim}, title = {A familial congenital heart disease with a possible multigenic origin involving a mutation in BMPR1A}, series = {Scientific reports}, volume = {9}, journal = {Scientific reports}, publisher = {Nature Publ. Group}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-019-39648-7}, pages = {12}, year = {2019}, abstract = {The genetics of many congenital heart diseases (CHDs) can only unsatisfactorily be explained by known chromosomal or Mendelian syndromes. Here, we present sequencing data of a family with a potentially multigenic origin of CHD. Twelve of nineteen family members carry a familial mutation [NM_004329.2:c.1328 G > A (p.R443H)] which encodes a predicted deleterious variant of BMPR1A. This mutation co-segregates with a linkage region on chromosome 1 that associates with the emergence of severe CHDs including Ebstein's anomaly, atrioventricular septal defect, and others. We show that the continuous overexpression of the zebrafish homologous mutation bmpr1aap.R438H within endocardium causes a reduced AV valve area, a downregulation of Wnt/ß-catenin signalling at the AV canal, and growth of additional tissue mass in adult zebrafish hearts. This finding opens the possibility of testing genetic interactions between BMPR1A and other candidate genes within linkage region 1 which may provide a first step towards unravelling more complex genetic patterns in cardiovascular disease aetiology.}, language = {en} } @article{EmuoyibofarheAkindeleRonkeetal.2019, author = {Emuoyibofarhe, Justice O. and Akindele, Akinyinka Tosin and Ronke, Babatunde Seyi and Omotosho, Adebayo and Meinel, Christoph}, title = {A Fuzzy Rule-Based Model for Remote Monitoring of Preterm in the Intensive Care Unit of Hospitals}, series = {International Journal of Medical Research \& Health Sciences}, volume = {8}, journal = {International Journal of Medical Research \& Health Sciences}, number = {5}, publisher = {Sumathi}, address = {Trichy}, issn = {2319-5886}, pages = {33 -- 44}, year = {2019}, abstract = {The use of Remote patient monitoring (RPM) systems to monitor critically ill patients in the Intensive Care Unit (ICU) has enabled quality and real-time healthcare management. Fuzzy logic as an approach to designing RPM systems provides a means for encapsulating the subjective decision-making process of medical experts in an algorithm suitable for computer implementation. In this paper, a remote monitoring system for preterm in neonatal ICU incubators is modeled and simulated. The model was designed with 4 input variables (body temperature, heart rate, respiratory rate, and oxygen level saturation), and 1 output variable (action performed represented as ACT). ACT decides whether-an alert is generated or not and also determines the message displayed when a notification is required. ACT classifies the clinical priority of the monitored preterm into 5 different fields: code blue, code red, code yellow, code green, and-code black. The model was simulated using a fuzzy logic toolbox of MATLAB R2015A. About 216 IF_THEN rules were formulated to monitor the inputs data fed into the model. The performance of the model was evaluated using-the confusion matrix to determine the model's accuracy, precision, sensitivity, specificity, and false alarm rate. The-experimental results obtained shows that the fuzzy-based system is capable of producing satisfactory results when used for monitoring and classifying the clinical statuses of neonates in ICU incubators.}, language = {en} } @article{LontsiGarciaJerezCamiloMolinaVillegasetal.2019, author = {Lontsi, Agostiny Marrios and Garcia-Jerez, Antonio and Camilo Molina-Villegas, Juan and Jose Sanchez-Sesma, Francisco and Molkenthin, Christian and Ohrnberger, Matthias and Kr{\"u}ger, Frank and Wang, Rongjiang and Fah, Donat}, title = {A generalized theory for full microtremor horizontal-to-vertical [H/V(z,f)] spectral ratio interpretation in offshore and onshore environments}, series = {Geophysical journal international}, volume = {218}, journal = {Geophysical journal international}, number = {2}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0956-540X}, doi = {10.1093/gji/ggz223}, pages = {1276 -- 1297}, year = {2019}, abstract = {Advances in the field of seismic interferometry have provided a basic theoretical interpretation to the full spectrum of the microtremor horizontal-to-vertical spectral ratio [H/V(f)]. The interpretation has been applied to ambient seismic noise data recorded both at the surface and at depth. The new algorithm, based on the diffuse wavefield assumption, has been used in inversion schemes to estimate seismic wave velocity profiles that are useful input information for engineering and exploration seismology both for earthquake hazard estimation and to characterize surficial sediments. However, until now, the developed algorithms are only suitable for on land environments with no offshore consideration. Here, the microtremor H/V(z, f) modelling is extended for applications to marine sedimentary environments for a 1-D layered medium. The layer propagator matrix formulation is used for the computation of the required Green's functions. Therefore, in the presence of a water layer on top, the propagator matrix for the uppermost layer is defined to account for the properties of the water column. As an application example we analyse eight simple canonical layered earth models. Frequencies ranging from 0.2 to 50 Hz are considered as they cover a broad wavelength interval and aid in practice to investigate subsurface structures in the depth range from a few meters to a few hundreds of meters. Results show a marginal variation of 8 per cent at most for the fundamental frequency when a water layer is present. The water layer leads to variations in H/V peak amplitude of up to 50 per cent atop the solid layers.}, language = {en} } @misc{BeisnerGrossartGasol2019, author = {Beisner, Beatrix E. and Grossart, Hans-Peter and Gasol, Josep M.}, title = {A guide to methods for estimating phago-mixotrophy in nanophytoplankton}, series = {Journal of plankton research}, volume = {41}, journal = {Journal of plankton research}, number = {2}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0142-7873}, doi = {10.1093/plankt/fbz008}, pages = {77 -- 89}, year = {2019}, abstract = {Growing attention to phytoplankton mixotrophy as a trophic strategy has led to significant revisions of traditional pelagic food web models and ecosystem functioning. Although some empirical estimates of mixotrophy do exist, a much broader set of in situ measurements are required to (i) identify which organisms are acting as mixotrophs in real time and to (ii) assess the contribution of their heterotrophy to biogeochemical cycling. Estimates are needed through time and across space to evaluate which environmental conditions or habitats favour mixotrophy: conditions still largely unknown. We review methodologies currently available to plankton ecologists to undertake estimates of plankton mixotrophy, in particular nanophytoplankton phago-mixotrophy. Methods are based largely on fluorescent or isotopic tracers, but also take advantage of genomics to identify phylotypes and function. We also suggest novel methods on the cusp of use for phago-mixotrophy assessment, including single-cell measurements improving our capacity to estimate mixotrophic activity and rates in wild plankton communities down to the single-cell level. Future methods will benefit from advances in nanotechnology, micromanipulation and microscopy combined with stable isotope and genomic methodologies. Improved estimates of mixotrophy will enable more reliable models to predict changes in food web structure and biogeochemical flows in a rapidly changing world.}, language = {en} } @misc{MyachykovFischer2019, author = {Myachykov, Andriy and Fischer, Martin H.}, title = {A hierarchical view of abstractness}, series = {Physics of life reviews}, volume = {29}, journal = {Physics of life reviews}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1571-0645}, doi = {10.1016/j.plrev.2019.04.005}, pages = {161 -- 163}, year = {2019}, language = {en} } @article{JantzenWozniakKappeletal.2019, author = {Jantzen, Friederike and Wozniak, Natalia Joanna and Kappel, Christian and Sicard, Adrien and Lenhard, Michael}, title = {A high‑throughput amplicon‑based method for estimating outcrossing rates}, series = {Plant Methods}, volume = {15}, journal = {Plant Methods}, number = {47}, publisher = {BioMed Central}, address = {London}, issn = {1746-4811}, doi = {10.1186/s13007-019-0433-9}, pages = {14}, year = {2019}, abstract = {Background: The outcrossing rate is a key determinant of the population-genetic structure of species and their long-term evolutionary trajectories. However, determining the outcrossing rate using current methods based on PCRgenotyping individual offspring of focal plants for multiple polymorphic markers is laborious and time-consuming. Results: We have developed an amplicon-based, high-throughput enabled method for estimating the outcrossing rate and have applied this to an example of scented versus non-scented Capsella (Shepherd's Purse) genotypes. Our results show that the method is able to robustly capture differences in outcrossing rates. They also highlight potential biases in the estimates resulting from differential haplotype sharing of the focal plants with the pollen-donor population at individual amplicons. Conclusions: This novel method for estimating outcrossing rates will allow determining this key population-genetic parameter with high-throughput across many genotypes in a population, enabling studies into the genetic determinants of successful pollinator attraction and outcrossing.}, language = {en} } @misc{GonzalezLopezPufahl2019, author = {Gonzalez-Lopez, Fernanda and Pufahl, Luise}, title = {A Landscape for Case Models}, series = {Enterprise, Business-Process and Information Systems Modeling}, volume = {352}, journal = {Enterprise, Business-Process and Information Systems Modeling}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-030-20618-5}, issn = {1865-1348}, doi = {10.1007/978-3-030-20618-5_6}, pages = {87 -- 102}, year = {2019}, abstract = {Case Management is a paradigm to support knowledge-intensive processes. The different approaches developed for modeling these types of processes tend to result in scattered models due to the low abstraction level at which the inherently complex processes are therein represented. Thus, readability and understandability is more challenging than that of traditional process models. By reviewing existing proposals in the field of process overviews and case models, this paper extends a case modeling language - the fragment-based Case Management (fCM) language - with the goal of modeling knowledge-intensive processes from a higher abstraction level - to generate a so-called fCM landscape. This proposal is empirically evaluated via an online experiment. Results indicate that interpreting an fCM landscape might be more effective and efficient than interpreting an informationally equivalent case model.}, language = {en} } @article{SchefflerImmenhauserPourteauetal.2019, author = {Scheffler, Franziska and Immenhauser, Adrian and Pourteau, Amaury and Natalicchio, Marcello and Candan, Osman and Oberh{\"a}nsli, Roland}, title = {A lost Tethyan evaporitic basin}, series = {Sedimentology : the journal of the International Association of Sedimentologists}, volume = {66}, journal = {Sedimentology : the journal of the International Association of Sedimentologists}, number = {7}, publisher = {Wiley}, address = {Hoboken}, issn = {0037-0746}, doi = {10.1111/sed.12606}, pages = {2627 -- 2660}, year = {2019}, abstract = {Ancient evaporite deposits are geological archives of depositional environments characterized by a long-term negative precipitation balance and bear evidence for global ocean element mass balance calculations. Here, Cretaceous selenite pseudomorphs from western Anatolia ('Rosetta Marble') — characterized by their exceptional morphological preservation — and their 'marine' geochemical signatures are described and interpreted in a process-oriented context. These rocks recorded Late Cretaceous high-pressure/low-temperature, subduction-related metamorphism with peak conditions of 1·0 to 1·2 GPa and 300 to 400°C. Metre-scale, rock-forming radiating rods, now present as fibrous calcite marble, clearly point to selenitic gypsum as the precursor mineral. Stratigraphic successions are recorded along a reconstructed proximal to distal transect. The cyclical alternation of selenite beds and radiolarian ribbon-bedded cherts in the distal portions are interpreted as a two type of seawater system. During arid intervals, shallow marine brines cascaded downward into basinal settings and induced precipitation. During more humid times, upwelling-induced radiolarian blooms caused the deposition of radiolarite facies. Interestingly, there is no comparable depositional setting known from the Cenozoic world. Meta-selenite geochemical data (δ13C, δ18O and 87Sr/86Sr) plot within the range of reconstructed middle Cretaceous seawater signatures. Possible sources for the 13C-enriched (mean 2·2 per mille) values include methanogenesis, gas hydrates and cold seep fluid exhalation. Spatially resolved component-specific analysis of a rock slab displays isotopic variances between meta-selenite crystals (mean δ13C 2·2 per mille) and host matrix (mean δ13C 1·3 per mille). The Cretaceous evaporite-pseudomorphs of Anatolia represent a basin wide event coeval with the Aptian evaporites of the Proto-Atlantic and the pseudomorphs share many attributes, including lateral distribution of 600 km and stratigraphic thickness of 1·5 to 2·0 km, with the evaporites formed during the younger Messinian salinity crisis. The Rosetta Marble of Anatolia may represent the best-preserved selenite pseudomorphs worldwide and have a clear potential to act as a template for the study of meta-selenite in deep time.}, language = {en} } @article{SchiroColangeliMueller2019, author = {Schiro, Gabriele and Colangeli, Pierluigi and M{\"u}ller, Marina E. H.}, title = {A Metabarcoding Analysis of the Mycobiome of Wheat Ears Across a Topographically Heterogeneous Field}, series = {Frontiers in microbiology}, volume = {10}, journal = {Frontiers in microbiology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-302X}, doi = {10.3389/fmicb.2019.02095}, pages = {12}, year = {2019}, language = {en} } @article{PornsawadSapsakulBoeckmann2019, author = {Pornsawad, Pornsarp and Sapsakul, Nantawan and B{\"o}ckmann, Christine}, title = {A modified asymptotical regularization of nonlinear ill-posed problems}, series = {Mathematics}, volume = {7}, journal = {Mathematics}, edition = {5}, publisher = {MDPI}, address = {Basel, Schweiz}, issn = {2227-7390}, doi = {10.3390/math7050419}, pages = {19}, year = {2019}, abstract = {In this paper, we investigate the continuous version of modified iterative Runge-Kutta-type methods for nonlinear inverse ill-posed problems proposed in a previous work. The convergence analysis is proved under the tangential cone condition, a modified discrepancy principle, i.e., the stopping time T is a solution of ∥𝐹(𝑥𝛿(𝑇))-𝑦𝛿∥=𝜏𝛿+ for some 𝛿+>𝛿, and an appropriate source condition. We yield the optimal rate of convergence.}, language = {en} } @article{SchwarzenthalJuangSchachneretal.2019, author = {Schwarzenthal, Miriam Jelena and Juang, Linda P. and Schachner, Maja Katharina and van de Vijver, Fons J. R.}, title = {A multimodal measure of cultural intelligence for adolescents growing up in culturally diverse societies}, series = {International Journal of Intercultural Relations}, volume = {72}, journal = {International Journal of Intercultural Relations}, publisher = {Elsevier}, address = {Oxford}, issn = {0147-1767}, doi = {10.1016/j.ijintrel.2019.07.007}, pages = {109 -- 121}, year = {2019}, abstract = {Adolescents growing up in culturally diverse societies need to develop intercultural competence. To better understand how to develop intercultural competence we need measures specifically relating to the everyday intercultural experiences of adolescents. However, few measures of intercultural competence are available for this target group. Based on the cultural intelligence (CQ) model (Earley \& Ang, 2003), we developed a measure that combines a self-report questionnaire and situational judgment tests (SJTs). The latter comprise a brief description of intercultural situations, followed by questions asking the adolescents to interpret and provide a reaction to the situations. The reliability, factor structure, measurement equivalence, and validity of the new measure was tested in two samples of adolescents in culturally diverse regions in North Rhine-Westphalia (N = 631, 48\% female, M-a(ge) = 13.69 years, SDage = 1.83) and Berlin (N = 1,335, 48\% female, M-age = 14.69 years, SDage, = 0.74) in Germany. The self-report CQ scale showed good reliability and a four-dimensional factor structure with a higher-order CQ factor. The responses to the SJTs were coded based on a coding manual and the ratings loaded onto one factor. The measurement models showed metric to scalar measurement equivalence across immigrant background, gender, and grade. The CQ factor and the SJT factor were positively correlated with each other, as well as with related constructs such as openness, perspective-taking, and diversity beliefs. We conclude that the new measure offers a reliable and valid method to assess the intercultural competence of adolescents growing up in culturally diverse societies.}, language = {en} } @article{ChaabeneNegraCapranicaetal.2019, author = {Chaabene, Helmi and Negra, Yassine and Capranica, Laura and Prieske, Olaf and Granacher, Urs}, title = {A Needs Analysis of Karate Kumite With Recommendations for Performance Testing and Training}, series = {Strength and conditioning journal}, volume = {41}, journal = {Strength and conditioning journal}, number = {3}, publisher = {Lippincott Williams \& Wilkins}, address = {Philadelphia}, issn = {1524-1602}, doi = {10.1519/SSC.0000000000000445}, pages = {35 -- 46}, year = {2019}, abstract = {An effective training program needs to be customized to the specific demands of the redpective sport. Therefore, it is important to conduct a needs analysis to gain information on the unique characteristics of the sport. The objectives of thes review were (A) to conduct a systematic needs analysis of karate kumite and (B) to provide practical recommendations for sport-specific performance testing and training of karate kumite athletes.}, language = {en} } @article{OzturkMalikCheungetal.2019, author = {Ozturk, Ugur and Malik, Nishant and Cheung, Kevin and Marwan, Norbert and Kurths, J{\"u}rgen}, title = {A network-based comparative study of extreme tropical and frontal storm rainfall over Japan}, series = {Climate dynamics : observational, theoretical and computational research on the climate system}, volume = {53}, journal = {Climate dynamics : observational, theoretical and computational research on the climate system}, number = {1-2}, publisher = {Springer}, address = {New York}, issn = {0930-7575}, doi = {10.1007/s00382-018-4597-1}, pages = {521 -- 532}, year = {2019}, abstract = {Frequent and intense rainfall events demand innovative techniques to better predict the extreme rainfall dynamics. This task requires essentially the assessment of the basic types of atmospheric processes that trigger extreme rainfall, and then to examine the differences between those processes, which may help to identify key patterns to improve predictive algorithms. We employ tools from network theory to compare the spatial features of extreme rainfall over the Japanese archipelago and surrounding areas caused by two atmospheric processes: the Baiu front, which occurs mainly in June and July (JJ), and the tropical storms from August to November (ASON). We infer from complex networks of satellite-derived rainfall data, which are based on the nonlinear correlation measure of event synchronization. We compare the spatial scales involved in both systems and identify different regions which receive rainfall due to the large spatial scale of the Baiu and tropical storm systems. We observed that the spatial scales involved in the Baiu driven rainfall extremes, including the synoptic processes behind the frontal development, are larger than tropical storms, which even have long tracks during extratropical transitions. We further delineate regions of coherent rainfall during the two seasons based on network communities, identifying the horizontal (east-west) rainfall bands during JJ over the Japanese archipelago, while during ASON these bands align with the island arc of Japan.}, language = {en} } @article{RheinwahltGoswamiBookhagen2019, author = {Rheinwahlt, Aljoscha and Goswami, Bedartha and Bookhagen, Bodo}, title = {A network-based flow accumulation algorithm for point clouds}, series = {Journal of geophysical research : Earth surface}, volume = {124}, journal = {Journal of geophysical research : Earth surface}, number = {7}, publisher = {American Geophysical Union}, address = {Washington}, issn = {2169-9003}, doi = {10.1029/2018JF004827}, pages = {2013 -- 2033}, year = {2019}, abstract = {Flow accumulation algorithms estimate the steady state of flow on real or modeled topographic surfaces and are crucial for hydrological and geomorphological assessments, including delineation of river networks, drainage basins, and sediment transport processes. Existing flow accumulation algorithms are typically designed to compute flows on regular grids and are not directly applicable to arbitrarily sampled topographic data such as lidar point clouds. In this study we present a random sampling scheme that generates homogeneous point densities, in combination with a novel flow path tracing approach-the Facet-Flow Network (FFN)-that estimates flow accumulation in terms of specific catchment area (SCA) on triangulated surfaces. The random sampling minimizes biases due to spatial sampling and the FFN allows for direct flow estimation from point clouds. We validate our approach on a Gaussian hill surface and study the convergence of its SCA compared to the analytical solution. Here, our algorithm outperforms the multiple flow direction algorithm, which is optimized for divergent surfaces. We also compute the SCA of a 6-km(2)-steep, vegetated catchment on Santa Cruz Island, California, based on airborne lidar point-cloud data. Point-cloud-based SCA values estimated by our method compare well with those estimated by the D-infinity or multiple flow direction algorithm on gridded data. The advantage of computing SCA from point clouds becomes relevant especially for divergent topography and for small drainage areas: These are depicted with much more detail due to the higher sampling density of point clouds.}, language = {en} } @misc{AwasthiKaminskiRappetal.2019, author = {Awasthi, Swapnil and Kaminski, Jakob and Rapp, Michael Armin and Schlagenhauf, Florian and Walter, Henrik and Ruggeri, Barbara and Ripke, Stephan and Schumann, Gunter and Heinz, Andreas}, title = {A neural signature of malleability}, series = {European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology}, volume = {29}, journal = {European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0924-977X}, doi = {10.1016/j.euroneuro.2017.08.139}, pages = {S858 -- S859}, year = {2019}, abstract = {General intelligence has a substantial genetic background in children, adolescents, and adults, but environmental factors also strongly correlate with cognitive performance as evidenced by a strong (up to one SD) increase in average intelligence test results in the second half of the previous century. This change occurred in a period apparently too short to accommodate radical genetic changes. It is highly suggestive that environmental factors interact with genotype by possible modification of epigenetic factors that regulate gene expression and thus contribute to individual malleability. This modification might as well be reflected in recent observations of an association between dopamine-dependent encoding of reward prediction errors and cognitive capacity, which was modulated by adverse life events.}, language = {en} } @article{SaguTchewonpiHuschekBoenicketal.2019, author = {Sagu Tchewonpi, Sorel and Huschek, Gerd and B{\"o}nick, Josephine and Homann, Thomas and Rawel, Harshadrai Manilal}, title = {A New Approach of Extraction of α-Amylase/trypsin Inhibitors from Wheat (Triticum aestivum L.), Based on Optimization Using Plackett-Burman and Box-Behnken Designs}, series = {molecules}, volume = {24}, journal = {molecules}, number = {19}, publisher = {MDPI}, address = {Basel}, issn = {1420-3049}, doi = {10.3390/molecules24193589}, pages = {18}, year = {2019}, abstract = {Wheat is one of the most consumed foods in the world and unfortunately causes allergic reactions which have important health effects. The α-amylase/trypsin inhibitors (ATIs) have been identified as potentially allergen components of wheat. Due to a lack of data on optimization of ATI extraction, a new wheat ATIs extraction approach combining solvent extraction and selective precipitation is proposed in this work. Two types of wheat cultivars (Triticum aestivum L.), Julius and Ponticus were used and parameters such as solvent type, extraction time, temperature, stirring speed, salt type, salt concentration, buffer pH and centrifugation speed were analyzed using the Plackett-Burman design. Salt concentration, extraction time and pH appeared to have significant effects on the recovery of ATIs (p < 0.01). In both wheat cultivars, Julius and Ponticus, ammonium sulfate substantially reduced protein concentration and inhibition of amylase activity (IAA) compared to sodium chloride. The optimal conditions with desirability levels of 0.94 and 0.91 according to the Doehlert design were: salt concentrations of 1.67 and 1.22 M, extraction times of 53 and 118 min, and pHs of 7.1 and 7.9 for Julius and Ponticus, respectively. The corresponding responses were: protein concentrations of 0.31 and 0.35 mg and IAAs of 91.6 and 83.3\%. Electrophoresis and MALDI-TOF/MS analysis showed that the extracted ATIs masses were between 10 and 20 kDa. Based on the initial LC-MS/MS analysis, up to 10 individual ATIs were identified in the extracted proteins under the optimal conditions. The positive implication of the present study lies in the quick assessment of their content in different varieties especially while considering their allergenic potential.}, language = {en} } @article{KellerMuench2019, author = {Keller, Matthias and M{\"u}nch, Florentin}, title = {A new discrete Hopf-Rinow theorem}, series = {Discrete Mathematics}, volume = {342}, journal = {Discrete Mathematics}, number = {9}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0012-365X}, doi = {10.1016/j.disc.2019.03.014}, pages = {2751 -- 2757}, year = {2019}, abstract = {We prove a version of the Hopf-Rinow theorem with respect to path metrics on discrete spaces. The novel aspect is that we do not a priori assume local finiteness but isolate a local finiteness type condition, called essentially locally finite, that is indeed necessary. As a side product we identify the maximal weight, called the geodesic weight, generating the path metric in the situation when the space is complete with respect to any of the equivalent notions of completeness proven in the Hopf-Rinow theorem. As an application we characterize the graphs for which the resistance metric is a path metric induced by the graph structure.}, language = {en} } @article{YuanBraunGueritetal.2019, author = {Yuan, Xiaoping P. and Braun, Jean and Guerit, Laure and Rouby, D. and Cordonnier, G.}, title = {A New Efficient Method to Solve the Stream Power Law Model Taking Into Account Sediment Deposition}, series = {Journal of geophysical research : Earth surface}, volume = {124}, journal = {Journal of geophysical research : Earth surface}, number = {6}, publisher = {American Geophysical Union}, address = {Washington}, issn = {2169-9003}, doi = {10.1029/2018JF004867}, pages = {1346 -- 1365}, year = {2019}, abstract = {The stream power law model has been widely used to represent erosion by rivers but does not take into account the role played by sediment in modulating erosion and deposition rates. Davy and Lague (2009, ) provide an approach to address this issue, but it is computationally demanding because the local balance between erosion and deposition depends on sediment flux resulting from net upstream erosion. Here, we propose an efficient (i.e., O(N) and implicit) method to solve their equation. This means that, unlike other methods used to study the complete dynamics of fluvial systems (e.g., including the transition from detachment-limited to transport-limited behavior), our method is unconditionally stable even when large time steps are used. We demonstrate its applicability by performing a range of simulations based on a simple setup composed of an uplifting region adjacent to a stable foreland basin. As uplift and erosion progress, the mean elevations of the uplifting relief and the foreland increase, together with the average slope in the foreland. Sediments aggrade in the foreland and prograde to reach the base level where sediments are allowed to leave the system. We show how the topography of the uplifting relief and the stratigraphy of the foreland basin are controlled by the efficiency of river erosion and the efficiency of sediment transport by rivers. We observe the formation of a steady-state geometry in the uplifting region, and a dynamic steady state (i.e., autocyclic aggradation and incision) in the foreland, with aggradation and incision thicknesses up to tens of meters.}, language = {en} } @article{ChoiSchmidtTinnefeldetal.2019, author = {Choi, Youngeun and Schmidt, Carsten and Tinnefeld, Philip and Bald, Ilko and R{\"o}diger, Stefan}, title = {A new reporter design based on DNA origami nanostructures for quantification of short oligonucleotides using microbeads}, series = {Scientific Reports}, journal = {Scientific Reports}, number = {9}, publisher = {Macmillan Publishers Limited}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-019-41136-x}, pages = {8}, year = {2019}, abstract = {The DNA origami technique has great potential for the development of brighter and more sensitive reporters for fluorescence based detection schemes such as a microbead-based assay in diagnostic applications. The nanostructures can be programmed to include multiple dye molecules to enhance the measured signal as well as multiple probe strands to increase the binding strength of the target oligonucleotide to these nanostructures. Here we present a proof-of-concept study to quantify short oligonucleotides by developing a novel DNA origami based reporter system, combined with planar microbead assays. Analysis of the assays using the VideoScan digital imaging platform showed DNA origami to be a more suitable reporter candidate for quantification of the target oligonucleotides at lower concentrations than a conventional reporter that consists of one dye molecule attached to a single stranded DNA. Efforts have been made to conduct multiplexed analysis of different targets as well as to enhance fluorescence signals obtained from the reporters. We therefore believe that the quantification of short oligonucleotides that exist in low copy numbers is achieved in a better way with the DNA origami nanostructures as reporters.}, language = {en} } @article{SrokaGodunkoRutschmannetal.2019, author = {Sroka, Pavel and Godunko, Roman J. and Rutschmann, Sereina and Angeli, Kamila B. and Salles, Frederico F. and Gattolliat, Jean-Luc}, title = {A new species of Bungona in Turkey (Ephemeroptera, Baetidae)}, series = {Zoosytematics and evolution}, volume = {95}, journal = {Zoosytematics and evolution}, number = {1}, publisher = {Pensoft Publ.}, address = {Sofia}, issn = {1860-0743}, doi = {10.3897/zse.95.29487}, pages = {1 -- 13}, year = {2019}, abstract = {By using an integrative approach, we describe a new species of mayfly, Bungona (Chopralla) pontica sp. n., from Turkey. The discovery of a representative of the tropical mayfly genus Bungona in the Middle East is rather unexpected. The new species shows all the main morphological characters of the subgenus Chopralla, which has its closest related species occurring in southeastern Asia. Barcoding clearly indicated that the new species represents an independent lineage isolated for a very long time from other members of the complex. The claw is equipped with two rows of three or four flattened denticles. This condition is a unique feature of Bungona (Chopralla) pontica sp. n. among West Palaearctic mayfly species. Within the subgenus Chopralla, the species can be identified by the presence of a simple, not bifid right prostheca (also present only in Bungona (Chopralla) liebenauae (Soldan, Braasch \& Muu, 1987)), the shape of the labial palp, and the absence of protuberances on pronotum.}, language = {en} } @article{Turner2019, author = {Turner, Bryan S.}, title = {A Nineteenth-Century Turning Point}, series = {Regimes of happiness : comparative and historical studies}, journal = {Regimes of happiness : comparative and historical studies}, publisher = {Anthem Press.}, address = {London}, isbn = {978-1-78308-886-7}, pages = {235 -- 248}, year = {2019}, abstract = {Happiness as the ultimate goal of human endeavour is a thread running through theology and philosophy from the ancient Greeks to modern times. Such a claim raises immediately a host of critical objections and problems relating to the idea of cultural relativism. Can the theme of happiness be continuous and how would we know that? One way to overcome this dilemma is to identify 'regimes of happiness' - that is, clusters of ideas, practices and institutions that in one way or another connect to broad ideas of human wellbeing, flourishing and satisfaction or Eudaimonia to use the word that dominates Aristotle's Nicomachean Ethics (Contreras- Vejar and Turner, 2018). Contemporary discussions of happiness almost invariably start with Aristotle (Nagel, 1972). However, the methodology here is to some extent borrowed from Michel Foucault to understand the 'genealogy' of happiness across different social and cultural formations. In the Western world one could identify an Aristotelian regime of happiness based on the idea of a sound polity and flourishing citizens. There is also a Christian regime of happiness around such figures as St. Augustine and within which there have been radical shifts most notably brought about by Luther and the Protestant Reformation. Regimes of happiness can overlap with each other and their borders are obviously fuzzy. Some regimes may last a long time in various forms. For example, Aristotle's treatment of happiness is one of the most cited versions of happiness across the West. The idea of happiness is, however, not confined to the West. For example, the Vietnamese Constitution that was devised by Ho Chi Minh, an admirer of America society, crafted the 1945 Constitution with three key words as its primary values - Independence-freedom-happiness (or niem hanh phuc). The 2013 version of the Constitution in Article 3 says, 'The state guarantees […] that people enjoy what is abundant and free for a happy life with conditions for all- round development.' One further notion behind our discussion of 'regimes of happiness' is that in principle we can detect important shifts in regimes that are associated both with specific networks of individual thinkers, and with institutional changes in the location of intellectuals in these networks. In this chapter I am especially interested in the transitions in thinking about happiness from the late eighteenth century and through the nineteenth century.}, language = {en} } @article{KagelBierFrohmeetal.2019, author = {Kagel, Heike and Bier, Frank Fabian and Frohme, Marcus and Gl{\"o}kler, J{\"o}rn F.}, title = {A Novel Optical Method To Reversibly Control Enzymatic Activity Based On Photoacids}, series = {Scientific reports}, volume = {9}, journal = {Scientific reports}, publisher = {Nature Publishing Group}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-019-50867-w}, pages = {6}, year = {2019}, abstract = {Most biochemical reactions depend on the pH value of the aqueous environment and some are strongly favoured to occur in an acidic environment. A non-invasive control of pH to tightly regulate such reactions with defined start and end points is a highly desirable feature in certain applications, but has proven difficult to achieve so far. We report a novel optical approach to reversibly control a typical biochemical reaction by changing the pH and using acid phosphatase as a model enzyme. The reversible photoacid G-acid functions as a proton donor, changing the pH rapidly and reversibly by using high power UV LEDs as an illumination source in our experimental setup. The reaction can be tightly controlled by simply switching the light on and off and should be applicable to a wide range of other enzymatic reactions, thus enabling miniaturization and parallelization through non-invasive optical means.}, language = {en} } @article{KearneyShemlavanKnippenbergetal.2019, author = {Kearney, Eric and Shemla, Meir and van Knippenberg, Daan and Scholz, Florian A.}, title = {A paradox perspective on the interactive effects of visionary and empowering leadership}, series = {Organizational Behavior and Human Decision Processes}, volume = {155}, journal = {Organizational Behavior and Human Decision Processes}, publisher = {Elsevier}, address = {San Diego}, issn = {0749-5978}, doi = {10.1016/j.obhdp.2019.01.001}, pages = {20 -- 30}, year = {2019}, abstract = {In a multi-source, lagged design field study of 197 leader-follower dyads, we test a model that predicts positive interactive effects of visionary and empowering leadership on follower performance. Based on the paradox perspective, we argue that visionary and empowering leadership are synergistic in that their combination enables leaders to address a key paradox inherent to leader behavior identified by Waldman and Bowen (2016): Maintaining control while simultaneously letting go of control. We argue that visionary leadership addresses the former and empowering leadership addresses the latter pole of this pair of opposites. Hence, in line with paradox thinking, we posit that leaders will engender more positive effects on follower performance when they enact visionary and empowering leadership behaviors simultaneously and adopt a "both-and" approach, rather than focus on one of these behaviors without the other. Our results support our hypothesized interactive effect of visionary and empowering leadership on goal clarity, as well as a conditional indirect effect such that goal clarity mediates the interactive effect of visionary and empowering leadership on individual follower performance.}, language = {en} } @article{BoumaRichterFechner2019, author = {Bouma, Sietske Jeltje Deirdre and Richter, Philipp and Fechner, Cora}, title = {A population of high-velocity absorption-line systems residing in the Local Group}, series = {Astronomy and astrophysics : an international weekly journal}, volume = {627}, journal = {Astronomy and astrophysics : an international weekly journal}, publisher = {EDP Sciences}, address = {Les Ulis}, issn = {1432-0746}, doi = {10.1051/0004-6361/201935078}, pages = {12}, year = {2019}, abstract = {Aims. We investigated the ionisation conditions and distances of Galactic high-velocity clouds (HVCs) in the Galactic halo and beyond in the direction of the Local Group (LG) barycentre and anti-barycentre, by studying spectral data of 29 extragalactic background sources obtained with the Cosmic Origins Spectropgraph (COS) installed on the Hubble Space Telescope (HST). Methods. We model column-densities of low, intermediate, and high ions such as Si ii, C ii, Si iii, Si vi, and C iv, and use these data to construct a set of Cloudy ionisation models. Results. In total, we found 69 high-velocity absorption components along the 29 lines of sight. The components in the direction of the LG barycentre span the entire range of studied velocities, 100 less than or similar to vertical bar nu(LSR)vertical bar less than or similar to 400 km s(-1), while those in the anti-barycentre sample have velocities up to about 300 km s(-1). For 49 components, we infer the gas densities. In the direction of the LG barycentre, the gas densities exhibit a wide range from log nH = -3.96 to -2.55, while in the anti-barycentre direction the densities are systematically higher, log nH > -3.25. The barycentre absorbers can be split into two groups based on their density: a high-density group with log nH > -3.54, which can be affected by the Milky Way radiation field, and a low-density group (log nH <= -3.54). The latter has very low thermal pressures of P/k < 7.3 Kcm(-3). Conclusions. Our study shows that part of the absorbers in the LG barycentre direction trace gas at very low gas densities and thermal pressures. These properties indicate that the absorbers are located beyond the virial radius of the Milky Way. Our study also confirms results from earlier, single-sightline studies, suggesting the presence of a metal-enriched intragroup medium filling the LG near its barycentre.}, language = {en} } @article{Scianna2019, author = {Scianna, Bastian Matteo}, title = {A predisposition to brutality?}, series = {Small wars and insurgencies}, volume = {30}, journal = {Small wars and insurgencies}, number = {4-5}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0959-2318}, doi = {10.1080/09592318.2019.1638551}, pages = {968 -- 993}, year = {2019}, abstract = {The German Sonderweg thesis has been discarded in most research fields. Yet in regards to the military, things differ: all conflicts before the Second World War are interpreted as prelude to the war of extermination between 1939-1945. This article specifically looks at the Franco-Prussian War 1870-71 and German behaviour vis-a-vis regular combatants, civilians and irregular guerrilla fighters, the so-called francs-tireurs. The author argues that the counter-measures were not exceptional for nineteenth century warfare and also shows how selective reading of the existing secondary literature has distorted our view on the war.}, language = {en} }