@phdthesis{Kirchner2010,
  author    = {Kirchner, Henriette},
  title     = {The ghrelin system links dietary lipids with the endocrine control of energy homeostasis},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-52393},
  school      = {Universit{\"a}t Potsdam},
  year      = {2010},
  abstract  = {Ghrelin is a unique hunger-inducing stomach-borne hormone. It activates orexigenic circuits in the central nervous system (CNS) when acylated with a fatty acid residue by the Ghrelin O-acyltransferase (GOAT). Soon after the discovery of ghrelin a theoretical model emerged which suggests that the gastric peptide ghrelin is the first "meal initiation molecule},
  language  = {en}
}
@article{PaslakisBuchmannWestphaletal.2014,
  author    = {Paslakis, Georgios and Buchmann, Arlette F. and Westphal, Sabine and Banaschewski, Tobias and Hohm, Erika and Zimmermann, Ulrich S. and Laucht, Manfred and Deuschle, Michael},
  title     = {Intrauterine exposure to cigarette smoke is associated with increased ghrelin concentrations in adulthood},
  series = {Neuroendocrinology : international journal for basic and clinical studies on neuroendocrine relationships},
  volume    = {99},
  journal   = {Neuroendocrinology : international journal for basic and clinical studies on neuroendocrine relationships},
  number    = {2},
  publisher = {Karger},
  address   = {Basel},
  issn      = {0028-3835},
  doi       = {10.1159/000363325},
  pages     = {123 -- 129},
  year      = {2014},
  abstract  = {Background: The appetite-stimulating hormone ghrelin is a fundamental regulator of human energy metabolism. A series of studies support the notion that long-term appetite and weight regulation may be already programmed in early life and it could be demonstrated that the intrauterine environment affects the ghrelin system of the offspring. Animal studies have also shown that intrauterine programming of orexigenic systems persists even until adolescence/adulthood. Methods: We hypothesized that plasma ghrelin concentrations in adulthood may be associated with the intrauterine exposure to cigarette smoke. We examined this hypothesis in a sample of 19-year-olds followed up since birth in the framework of the Mannheim Study of Children at Risk, an ongoing epidemiological cohort study of the long-term outcome of early risk factors. Results: As a main finding, we found that ghrelin plasma concentrations in young adults who had been exposed to cigarette smoke in utero were significantly higher than in those without prenatal smoke exposure. Moreover, individuals with intrauterine nicotine exposure showed a significantly higher prevalence of own smoking habits and lower educational status compared to those in the group without exposure. Conclusion: Smoking during pregnancy may be considered as an adverse intrauterine influence that may alter the endocrine-metabolic status of the offspring even until early adulthood.},
  language  = {en}
}