@book{HuefnerKuehneHansenetal.2004,
  author    = {H{\"u}fner, Klaus and K{\"u}hne, Winrich and Hansen, Wiebke and Hett, Julia and Lampe, Otto and Lederer, Markus and Obser, Andreas and Sand, Peter H. and Strauß, Ekkehard},
  title     = {Integrative Konzepte bei der Reform der Vereinten Nationen},
  series = {Potsdamer UNO-Konferenzen},
  journal   = {Potsdamer UNO-Konferenzen},
  number    = {5},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-77187},
  publisher      = {Universit{\"a}t Potsdam},
  pages     = {70},
  year      = {2004},
  abstract  = {Am 25. und 26. Juni 2004 fand die sechste Konferenz des Forschungskreises Vereinte Nationen an der Universit{\"a}t Potsdam statt. Die Konferenz befaßte sich mit dem Thema „Integrative Konzepte in der Reform der Vereinten Nationen". Kennzeichnend f{\"u}r die „Potsdamer UNO-Konferenzen", die traditionell am letzten Wochenende im Juni veranstaltet werden, sind die Verbindung von Wissenschaft und Praxis auf der einen Seite und die Beteiligung unterschiedlicher Disziplinen auf der anderen. Sieben Referate besch{\"a}ftigten sich mit bisher nicht oder nicht gen{\"u}gend in der Arbeit der Vereinten Nationen einbezogenen Aspekten bei der Struktur-Reform. Die nachstehend abgedruckten sechs Beitr{\"a}ge - von Dr. Jochen Prantl, der zum Thema „Informelle Staatengruppen als Instrument zur Konfliktregulierung: Auswirkungen auf die Arbeitsweise des Sicherheitsrates der Vereinten Nationen" referiert hatte, lag bei der Drucklegung der Brosch{\"u}re kein Manuskript vor - und die zugeh{\"o}rigen Diskussionen, die hier zusammengefaßt wiedergegeben werden, geben ein anschauliches Bild von der Komplexit{\"a}t der Aufgabe „UN-Reform". Die damit verbundenen Fragen, die f{\"u}r das zuk{\"u}nftige Funktionieren der Vereinten Nationen, aber auch f{\"u}r das Klima innerhalb der internationalen Gemeinschaft sehr wichtig sind, werden in dieser Dokumentation diskutiert. Die im Forschungskreis vertretene deutschsprachige UN-Forschung machte auf der Konferenz deutlich, daß man zu kurz greift, wenn sich die Reformdiskussion auf den st{\"a}ndigen Sitz f{\"u}r die Bundesrepublik Deutschland im Sicherheitsrat beschr{\"a}nkt. Der Forschungskreis m{\"o}chte mit dieser Brosch{\"u}re allen Interessierten die M{\"o}glichkeit geben, andere, nicht minder wichtige Aspekte dieser Diskussion kennenzulernen. Der Forschungskreis dankt der Juristischen Fakult{\"a}t der Universit{\"a}t Potsdam f{\"u}r die Gastfreundschaft und dem MenschenRechtsZentrum der Universit{\"a}t Potsdam f{\"u}r die Kooperation bei der Organisation der Konferenz.},
  language  = {de}
}
@book{HuefnerKuehneHansenetal.2004,
  author    = {H{\"u}fner, Klaus and K{\"u}hne, Winrich and Hansen, Wiebke and Hett, Julia and Lampe, Otto and Lederer, Markus and Obser, Andreas and Sand, Peter H. and Strauß, Ekkehard and Volger, Helmut},
  title     = {Integrative Konzepte bei der Reform der Vereinten Nationen},
  series = {Potsdamer UNO-Konferenzen},
  volume    = {5},
  journal   = {Potsdamer UNO-Konferenzen},
  editor    = {Klein, Eckart},
  publisher = {MenschenRechtsZentrum},
  address   = {Potsdam},
  issn      = {1617-4704},
  pages     = {70 S.},
  year      = {2004},
  language  = {de}
}
@article{KuehneHansenHett2011,
  author    = {K{\"u}hne, Winrich and Hansen, Wiebke and Hett, Julia},
  title     = {Ziviles Personal in Friedenseins{\"a}tzen und Wahlbeobachtung},
  series = {Die Vereinten Nationen vor globalen Herausforderungen : Referate der Potsdamer UNO-Konferenzen 2000-2008},
  journal   = {Die Vereinten Nationen vor globalen Herausforderungen : Referate der Potsdamer UNO-Konferenzen 2000-2008},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-61061},
  pages     = {193 -- 200},
  year      = {2011},
  abstract  = {Inhalt: - I. Einleitung - II. Mandat des ZIF - 1. Training - 2. Rekrutierung - 3. Analyse und Lessons Learned - III. Westafrikaprojekt - IV. Probleme und Perspektiven},
  language  = {de}
}
@article{KuehneHansenHettetal.2004,
  author    = {K{\"u}hne, Winrich and Hansen, Wiebke and Hett, Julia and Weiß, Norman},
  title     = {Ziviles Personal in Friedenseins{\"a}tzen und Wahlbeobachtung - Die Rolle des Zentrums f{\"u}r Internationale Friedenseins{\"a}tze (ZIF)},
  series = {Integrative Konzepte bei der Reform der Vereinten Nationen , Potsdam, 25./26. Juni 2004},
  volume    = {2004},
  journal   = {Integrative Konzepte bei der Reform der Vereinten Nationen , Potsdam, 25./26. Juni 2004},
  number    = {5},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-101898},
  pages     = {27 -- 37},
  year      = {2004},
  abstract  = {Ziviles Personal in Friedenseins{\"a}tzen und Wahlbeobachtung - Die Rolle des Zentrums f{\"u}r Internationale Friedenseins{\"a}tze (ZIF) // Winrich K{\"u}hne in Zusammenarbeit mit Wibke Hansen und Julia Hett Ziviles Personal in Friedenseins{\"a}tzen und Wahlbeobachtung - Die Rolle des Zentrums f{\"u}r Internationale Friedenseins{\"a}tze (ZIF) - Diskussionszusammenfassung // Norman Weiß},
  language  = {de}
}
@article{MeinersPalmieriKlopfleischetal.2019,
  author    = {Meiners, Jana and Palmieri, Vittoria and Klopfleisch, Robert and Ebel, Jana-Fabienne and Japtok, Lukasz and Schumacher, Fabian and Yusuf, Ayan Mohamud and Becker, Katrin Anne and Z{\"o}ller, Julia and Hose, Matthias and Kleuser, Burkhard and Hermann, Dirk Matthias and Kolesnick, Richard N. and Buer, Jan and Hansen, Wiebke and Westendorf, Astrid M.},
  title     = {Intestinal acid sphingomyelinase protects from severe Pathogen-Driven Colitis},
  series = {Frontiers in immunology},
  volume    = {10},
  journal   = {Frontiers in immunology},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-3224},
  doi       = {10.3389/fimmu.2019.01386},
  pages     = {14},
  year      = {2019},
  abstract  = {Inflammatory diseases of the gastrointestinal tract are emerging as a global problem with increased evidence and prevalence in numerous countries. A dysregulated sphingolipid metabolism occurs in patients with ulcerative colitis and is discussed to contribute to its pathogenesis. In the present study, we determined the impact of acid sphingomyelinase (Asm), which catalyzes the hydrolysis of sphingomyelin to ceramide, on the course of Citrobacter (C.) rodentium-driven colitis. C. rodentium is an enteric pathogen and induces colonic inflammation very similar to the pathology in patients with ulcerative colitis. We found that mice with Asm deficiency or Asm inhibition were strongly susceptible to C. rodentium infection. These mice showed increased levels of C. rodentium in the feces and were prone to bacterial spreading to the systemic organs. In addition, mice lacking Asm activity showed an uncontrolled inflammatory T(h)1 and T(h)17 response, which was accompanied by a stronger colonic pathology compared to infected wild type mice. These findings identified Asm as an essential regulator of mucosal immunity to the enteric pathogen C. rodentium.},
  language  = {en}
}
@misc{PloehnEdelmannJaptoketal.2018,
  author    = {Pl{\"o}hn, Svenja and Edelmann, B{\"a}rbel and Japtok, Lukasz and He, Xingxuan and Hose, Matthias and Hansen, Wiebke and Schuchman, Edward H. and Eckstein, Anja and Berchner-Pfannschmidt, Utta},
  title     = {CD40 enhances sphingolipids in orbital fibroblasts},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {1099},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-46883},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-468837},
  pages     = {9},
  year      = {2018},
  abstract  = {PURPOSE. Graves' orbitopathy (GO) is an autoimmune orbital disorder associated with Graves' disease caused by thyrotropin receptor autoantibodies. Orbital fibroblasts (OFs) and CD40 play a key role in disease pathogenesis. The bioactive lipid sphingosine-1-phosphate (S1P) has been implicated in promoting adipogenesis, fibrosis, and inflammation in OFs. We investigated the role of CD40 signaling in inducing S1P activity in orbital inflammation. METHODS. OFs and T cells were derived from GO patients and healthy control (Ctl) persons. S1P abundance in orbital tissues was evaluated by immunofluorescence. OFs were stimulated with CD40 ligand and S1P levels were determined by ELISA. Further, activities of acid sphingomyelinase (ASM), acid ceramidase, and sphingosine kinase were measured by ultraperformance liquid chromatography. Sphingosine and ceramide contents were analyzed by mass spectrometry. Finally, the role for S1P in T-cell attraction was investigated by T-cell migration assays. RESULTS. GO orbital tissue showed elevated amounts of S1P as compared to control samples. Stimulation of CD40 induced S1P expression in GO-derived OFs, while Ctl-OFs remained unaffected. A significant increase of ASM and sphingosine kinase activities, as well as lipid formation, was observed in GO-derived OFs. Migration assay of T cells in the presence of SphK inhibitor revealed that S1P released by GO-OFs attracted T cells for migration. CONCLUSIONS. The results demonstrated that CD40 ligand stimulates GO fibroblast to produce S1P, which is a driving force for T-cell migration. The results support the use of S1P receptor signaling modulators in GO management.},
  language  = {en}
}
@article{PloehnEdelmannJaptoketal.2018,
  author    = {Pl{\"o}hn, Svenja and Edelmann, B{\"a}rbel and Japtok, Lukasz and He, Xingxuan and Hose, Matthias and Hansen, Wiebke and Schuchman, Edward H. and Eckstein, Anja and Berchner-Pfannschmidt, Utta},
  title     = {CD40 enhances sphingolipids in orbital fibroblasts},
  series = {Investigative ophthalmology \& visual science},
  volume    = {59},
  journal   = {Investigative ophthalmology \& visual science},
  number    = {13},
  publisher = {Association for Research in Vision and Opthalmology},
  address   = {Rockville},
  issn      = {0146-0404},
  doi       = {10.1167/iovs.18-25466},
  pages     = {5391 -- 5397},
  year      = {2018},
  abstract  = {METHODS. OFs and T cells were derived from GO patients and healthy control (Ctl) persons. S1P abundance in orbital tissues was evaluated by immunofluorescence. OFs were stimulated with CD40 ligand and S1P levels were determined by ELISA. Further, activities of acid sphingomyelinase (ASM), acid ceramidase, and sphingosine kinase were measured by ultraperformance liquid chromatography. Sphingosine and ceramide contents were analyzed by mass spectrometry. Finally, the role for S1P in T-cell attraction was investigated by T-cell migration assays. RESULTS. GO orbital tissue showed elevated amounts of S1P as compared to control samples. Stimulation of CD40 induced S1P expression in GO-derived OFs, while Ctl-OFs remained unaffected. A significant increase of ASM and sphingosine kinase activities, as well as lipid formation, was observed in GO-derived OFs. Migration assay of T cells in the presence of SphK inhibitor revealed that S1P released by GO-OFs attracted T cells for migration. CONCLUSIONS. The results demonstrated that CD40 ligand stimulates GO fibroblast to produce S1P, which is a driving force for T-cell migration. The results support the use of S1P receptor signaling modulators in GO management.},
  language  = {en}
}