@article{RuehlThielLackeretal.2001,
  author    = {R{\"u}hl, Ralph and Thiel, Renate and Lacker, Tanja Silke and Srohschein, Sabine and Albert, Klaus and Nau, Heinz},
  title     = {Synthesis, high-performance liquid chromatography-nuclear magnetic resonance characterization and pharmacokinetics in mice of CD271 glucuronide},
  year      = {2001},
  language  = {en}
}
@article{ElmazarRuehlNau2001,
  author    = {Elmazar, Mohamed M. A. and R{\"u}hl, Ralph and Nau, Heinz},
  title     = {Synergistic Teratogenic Effects Induced by Retinoids in Mice by Coadministration of a RARa- or RARy-Selective Agonist with a RXR-Selective Agonist},
  year      = {2001},
  language  = {en}
}
@article{RuehlHamscherGarciaetal.2004,
  author    = {R{\"u}hl, Ralph and Hamscher, Gerd and Garcia, Ada and Nau, Heinz and Schweigert, Florian J.},
  title     = {Identification of 14-hydroxy-retro-retinol and 4-hydroxy-retinol as endogenous retinoids in rats throughout neonatal development},
  issn      = {0024-3205},
  year      = {2004},
  abstract  = {14-Hydroxy-retro-retinol was previously described as an in vivo and in vitro metabolite of retinol. Furthermore, the retinoid 4-hydroxy-retinol was identified as an endogenous occurring retinoid in the amphibian organism and an in vitro metabolite of retinol. We describe in the present study that 14-hydroxy-retro-retinol and 4-hydroxy- retinol are present in normal neonatal rat serum as endogenous occurring retinoids in normal non-vitamin A supplemented mammals (rats). Both retinoids were detected in serum and liver of neonatal rats at days 3 and 11 after birth. The respective concentrations at day 11 after birth were 41.8 +/- 2.8 ng/ml (serum)/ 104 +/- 6 ng/g (liver) for 4-hydroxy- retinol and 23 +/- 4.6 ng/ml (serum)/ 285 +/- 5 ng/g (liver) for 14-hydroxy-retro-retinol. Both retinoids could not be detected in adult rat serum and liver. From our experiments important physiological functions of these retinoids during postnatal development could be postulated. (C) 2004 Elsevier Inc. All rights reserved},
  language  = {en}
}
@article{RuehlPlumElmazaretal.2001,
  author    = {R{\"u}hl, Ralph and Plum, Claudia and Elmazar, Mohamed M. A. and Nau, Heinz},
  title     = {Embryonic Subcellular Distribution of 13-cis- and All-trans-Retinoic Acid Indicates Differential Cytosolic/ Nuclear Localization},
  year      = {2001},
  language  = {en}
}
@article{RuehlSassNauetal.2001,
  author    = {R{\"u}hl, Ralph and Sass, J{\"o}rn Oliver and Nau, Heinz and Klug, Stephan},
  title     = {Effects of all-trans-retinoic acid and all-trans-retinoyl glucuronide in two in vitro systems of distinct biological complexity},
  year      = {2001},
  language  = {en}
}
@article{FritzscheSchuchardtSchmidtetal.2010,
  author    = {Fritzsche, Britta and Schuchardt, Jan-Philipp and Schmidt, Anja and Nau, Heinz and Schweigert, Florian J. and Ruehl, Ralph},
  title     = {CYP26A1-specific antagonist influence on embryonic implantation, gene expression and endogenous retinoid concentration in rats},
  issn      = {0890-6238},
  doi       = {10.1016/j.reprotox.2010.05.005},
  year      = {2010},
  abstract  = {Retinoids are essential in vertebrate reproduction and embryonic development. All-trans-retinoic acid (ATRA) is tightly regulated during these processes. CYP26A1 is mainly responsible for its degradation. To study the role of CYP26A1 during implantation, we applied R115866, a CYP26A1-specific antagonist, to rats during early gestation days (GD). On GD 6.5 and 12 samples were collected and the number of embryos was evaluated. ATRA concentration increased in uterus and serum, mRNA expression of CYP26A1 and CRABP2 increased in the liver, but not in the uterus. Uterine COX1 and 17 beta HSD mRNA expression was decreased. The number of embryos on GD 12 was not altered in this setting. It can be concluded that uterine expression of the analyzed retinoid-response genes during early gestation is not altered by this R115866 treatment and instead indirectly via ATRA. From our experiment we cannot confirm that ATRA obtains a major influencing role in the regulation of embryonic implantation.},
  language  = {en}
}