@article{GraubaumLuderZunft2004,
  author    = {Graubaum, Hans-Joachim and Luder, W. and Zunft, Hans-Joachim Franz},
  title     = {A new isolated soy protein with high levels of nondenaturated protein shows twice the cholesterol-lowering effect of a commercial isolated soy protein},
  issn      = {0022-3166},
  year      = {2004},
  language  = {en}
}
@article{HoieMorgensternGruenwaldetal.2004,
  author    = {Hoie, Lars H. and Morgenstern, E. C. A. and Gr{\"u}nwald, J{\"o}rg and Graubaum, Hans-Joachim and Luder, W. and Zunft, Hans-Joachim Franz},
  title     = {Combining soy protein with phospholipids and fiber doubles the lipid-lowering effects compared with soy protein alone},
  issn      = {0022-3166},
  year      = {2004},
  language  = {en}
}
@article{KoebnickPlankHabibiWirsametal.2004,
  author    = {Koebnick, Corinna and Plank-Habibi, S. and Wirsam, B. and Gruendel, Sindy and Hahn, A. and Meyer-Kleine, C. and Leitzmann, C. and Zunft, Hans-Joachim Franz},
  title     = {Double-blind, randomized feedback control fails to improve the hypocholesterolemic effect of a plant-based low- fat diet in patients with moderately elevated total cholesterol levels},
  year      = {2004},
  abstract  = {Objective: To determine whether the cholesterol-lowering effect of a plant-based low-fat diet can be improved by a flexible control design that controls the extent of fat reduction based on the individual response of blood cholesterol. Design: Randomized, double-blind intervention study. Setting: A hotel in Prerow, Germany. Subjects: A total of 32 participants ( 21 female and 11 male participants) with total cholesterol level >5.7 mmol/l. Intervention: The control group consumed a plant-based low-fat diet with constantly 20\% of energy as fat; the intervention group received a diet with either 20 or 15\% of energy as fat, depending on the serum cholesterol response of the preceding week. A flexible control design based on the individual cholesterol response during a run-in period of 1 week was used within a low-fat intervention. Results: During the run-in period, the consumption of a plant-based low-fat diet led to a reduction in total cholesterol by 18 +/- 6 mmol/l ( P<0.001), in LDL cholesterol by 19 +/- 9 mmol/l ( P<0.001) and triglycerides by 13 +/- 3 mmol/l ( P<0.001). During the feedback control period, an additional reduction in total cholesterol by 13 +/- 8 ( P<0.001) and in LDL cholesterol by 17 +/- 11 (P<0.001) was observed compared to 15715 and 7718 in the control group. The effect of an additional feedback control was only marginal and not statistically significant compared to the effect of the low-fat diet alone. Conclusions: On a level of fat intake already reduced to 20\% of energy, the use of a feedback control to adapt the fat content of the diet depending on the individual serum cholesterol response was not more effective in reducing blood cholesterol levels than a plant-based low-fat diet alone. Sponsorship: Institute of Micro-Ecology, Herborn; the Stoll VITA Foundation, Waldshut; ALBAT+WIRSAM Software, Linden; Reformhaus Technical College, Oberstedten; Kolln Flocken Werke, Elmshorn, all in Germany},
  language  = {en}
}
@article{KoebnickZunft2004,
  author    = {Koebnick, Corinna and Zunft, Hans-Joachim Franz},
  title     = {Potential of dietary fibre from carob pods in the prevention and therapy of hypercholesterolemia and metabolic syndrome},
  issn      = {0174-0008},
  year      = {2004},
  abstract  = {Soluble, viscous, but not insoluble dietary fibre has been shown to lower serum cholesterol. Due to the high content of polyphenols, however, insoluble dietary fibre from carob pods may have physiological benefits beyond those of the usual insoluble dietary fibre preparations. Insoluble polyphenol-rich fibre preparations from carob pods have also been shown to significantly lower serum total and LDL cholesterol in cholesterol-fed rodents (hamsters, rats), while HDL and triglycerides remained unchanged. An increased fecal excretion of bile acids caused by binding to the fibre constituents is supposed to be responsible for this effect. In human studies, consumption of 15 g/d of a carob fibre preparation over 6 weeks lowered LDL cholesterol by 11.0\% in hypercholesterolemic subjects. This suggests that carob fibre may be effective in the dietary treatment of hypercholesterolernia. Recent studies have also shown that dietary fiber rich in polyphenols may (1) lower the glycemic index of food and (2) have anti-inflammatory effect. If carob fibre shows similar effects, it may be of special interest in the treatment of the metabolic syndrome},
  language  = {en}
}
@article{GerickeKoebnickReimannetal.2004,
  author    = {Gericke, Beate and Koebnick, Corinna and Reimann, Manja and Forterre, Simone and Zunft, Hans-Joachim Franz and Schweigert, Florian J.},
  title     = {Influence of hormone replacement therapy on proteomic pattern in serum of postmenopausal women},
  year      = {2004},
  abstract  = {Objectives: Proteomics approaches to cardiovascular biology and disease hold the promise of identifying specific proteins and peptides or modification thereof to assist in the identification of novel biomarkers. Method: By using surface-enhanced laser desorption and ionization time of flight mass spectroscopy (SELDI-TOF-MS) serum peptide and protein patterns were detected enabling to discriminate between postmenopausal women with and without hormone replacement therapy (HRT). Results: Serum of 13 HRT and 27 control subjects was analyzed and 42 peptides and proteins could be tentatively identified based on their molecular weight and binding characteristics on the chip surface. By using decision tree-based Biomarker Patterns (TM) Software classification and regression analysis a discriminatory function was developed allowing to distinguish between HRT women and controls correctly and, thus, yielding a sensitivity of 100\% and a specificity of 100\%. The results show that peptide and protein patterns have the potential to deliver novel biomarkers as well as pinpointing targets for improved treatment. The biomarkers obtained represent a promising tool to discriminate between HRT users and non-users. Conclusion: According to a tentative identification of the markers by their molecular weight and binding characteristics, most of them appear to be part of the inflammation induced acute-phase response. (c) 2004 Elsevier Ireland Ltd. All rights reserved},
  language  = {en}
}