@article{BaesslerWeissWienkoopetal.2009,
  author    = {Baessler, Olivia Y. and Weiss, Julia and Wienkoop, Stefanie and Lehmann, Karola and Scheler, Christian and Doelle, Sabine and Schwarz, Dietmar and Franken, Philipp and George, Eckhard and Worm, Margitta and Weckwerth, Wolfram},
  title     = {Evidence for novel tomato seed allergens : IgE-reactive legumin and vicilin proteins identified by multidimensional protein fractionation-mass spectrometry and in silico epitope modeling},
  issn      = {1535-3893},
  doi       = {10.1021/Pr800186d},
  year      = {2009},
  abstract  = {Tomato fruit and seed allergens were detected by IgE-immunoblotting using sera from 18 adult tomato-sensitized patients selected based on a positive history skin prick test (SPT) and specific Immunglobulin (Ig) E-levels. Isolated tomato seed total protein showed high SPT activity comparable or even higher than tomato fruit protein. For the molecular characterization of tomato seed allergens, a multidimensional protein fractionation strategy and LC-MS/MS was used. Two legumin- and vicilin-proteins were purified and showed strong IgE-reactivity in immunoblots. Individual patient sera exhibited varying IgE-sensitivity against the purified proteins. In silico structural modeling indicates high homology between epitopes of known walnut allergens and the detected IgE-crossreactive tomato proteins.},
  language  = {en}
}
@article{GarciaRuehlHerzetal.2003,
  author    = {Garcia, Ada and R{\"u}hl, Ralph and Herz, U. and Koebnick, Corinna and Schweigert, Florian J. and Worm, Margitta},
  title     = {Retinoid- and carotenoid-enriched diets influence the ontogenesis of the immune system in mice},
  year      = {2003},
  language  = {en}
}
@article{KochBrovkinaRuehletal.2006,
  author    = {Koch, Christin and Brovkina, Lioudmila and R{\"u}hl, Ralph and Worm, Margitta},
  title     = {Immunomodulation by dietary n3-polyunsaturated fatty acids (PUFA) in vitro},
  issn      = {0091-6749},
  year      = {2006},
  language  = {en}
}
@article{RuehlGarciaSchweigertetal.2004,
  author    = {R{\"u}hl, Ralph and Garcia, Ada and Schweigert, Florian J. and Worm, Margitta},
  title     = {Modulation of cytokine production by low and high retinoid diet in ovalbumin-sensitized mice},
  year      = {2004},
  abstract  = {Retinoids modulate many physiological processes such as the differentiation and growth of different cell types. including cells from the immune system. We have previously shown that retinoids modulate IgE production in vitro and in vivo. In the present study we investigated the effects of retinoids in non-sensitized and ovalbumin-sensitized mice that were fed for 11 weeks with three different vitamin A (VA) diets: a) VA-deficiency diet, b) base diet, and c) base diet supplemented with 0.5\% all-trans-retinoic acid (ATRA). Phorbol-myristate-acetate (PMA)/ionomycin-stimulated SMC (splenic mononuclear cells) from mice fed with ATRA and the vitamin A-deficient diet group showed increased interleukin-4 (IL-4) responses in non-sensitized mice. After ovalbumin sensitization in the VA-deficient and the ATRA supplementation diet groups, no significant effects on IL-4 production were observed. By contrast, gamma interferon (IFN-gamma production from PMA/ionomycin-stimulated SMC was enhanced in the VA-deficient diet group in ovalbumin-sensitized mice, and also in non-sensitized mice compared to the base and the ATRA-supplemented diet group. The data indicate that VA and retinoid content in a diet influences the cytokine response in non-sensitized and also ovalbumin-sensitized mice. Therefore these molecules may serve as active modulators of cytokine production in vivo that are responsible for the induction and persistence of atopic diseases},
  language  = {en}
}