@article{EisoldSellrieMemczaketal.2018, author = {Eisold, Ursula and Sellrie, Frank and Memczak, Henry and Andersson, Anika and Schenk, J{\"o}rg A. and Kumke, Michael Uwe}, title = {Dye tool box for a fluorescence enhancement immunoassay}, series = {Bioconjugate chemistry}, volume = {29}, journal = {Bioconjugate chemistry}, number = {1}, publisher = {American Chemical Society}, address = {Washington}, issn = {1043-1802}, doi = {10.1021/acs.bioconjchem.7b00731}, pages = {203 -- 214}, year = {2018}, abstract = {Immunochemical analytical methods are very successful in clinical diagnostics and are nowadays also emerging in the control of food as well as monitoring of environmental issues. Among the different immunoassays, luminescence based formats are characterized by their outstanding sensitivity making this format especially attractive for future applications. The need for multiparameter detection capabilities calls for a tool box of dye labels in order to transduce the biochemical reaction into an optically detectable signal. Here, in a multiparameter approach each analyte may be detected by a different dye with a unique emission color (covering the blue to red spectral range) or a unique luminescence decay kinetics. In the case of a competitive immunoassay format for each of the different dye labels an individual antibody would be needed. In the present paper a slightly modified approach is presented using a 7-aminocoumarin unit as the basic antigen against which highly specific antibodies were generated. Leaving the epitope region in the dyes unchanged but introducing a side group in positon 3 of the coumarin system allowed us to tune the optical properties of the coumarin dyes without the necessity of new antibody generation. Upon modification of the parent coumarin unit the full spectral range from blue to deep red was accessed. In the manuscript the photophysical characterization of the coumarin derivatives and their corresponding immunocomplexes with two highly specific antibodies is presented. The coumarin dyes and their immunocomplexes were characterized by steady-state and time-resolved absorption as well as emission spectroscopy. Moreover, fluorescence depolarization measurements were carried out to complement the data stressing the different binding modes of the two antibodies. The binding modes were evaluated using the photophysics of 7-aminocoumarins and how it was affected in the respective immunocomplexes, namely, the formation of the intramolecular charge transfer (ICT) as well as the twisted intramolecular charge transfer (TICT). In contrast to other antibody-dye pairs reported a distinct fluorescence enhancement upon formation of the antibody-dye complex up to a factor of SO was found. Because of the easy emission color tuning by tailoring the coumarin substitution for the antigen binding in nonrelevant position 3 of the parent molecule, a dye tool box is on hand which can be used in the construction of competitive multiparameter fluorescence enhancement immunoassays (FenIA).}, language = {en} } @article{VietzeJuangSchachneretal.2018, author = {Vietze, Jana and Juang, Linda P. and Schachner, Maja Katharina and Werneck, Harald}, title = {Feeling Half-Half?}, series = {Identity : an International Journal of Theory and Research}, volume = {18}, journal = {Identity : an International Journal of Theory and Research}, number = {1}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {1528-3488}, doi = {10.1080/15283488.2017.1410159}, pages = {60 -- 76}, year = {2018}, abstract = {Growing up in multicultural environments, Turkish-heritage individuals in Europe face specific challenges in combining their multiple cultural identities to form a coherent sense of self. Drawing from social identity complexity, this study explores four modes of combining cultural identities and their variation in relational contexts. Problem-centered interviews with Turkish-heritage young adults in Austria revealed the preference for complex, supranational labels, such as multicultural. Furthermore, most participants described varying modes of combining cultural identities over time and across relational contexts. Social exclusion experiences throughout adolescence related to perceived conflict of cultural identities, whereas multicultural peer groups supported perceived compatibility of cultural identities. Findings emphasize the need for complex, multidimensional approaches to study ethnic minorities' combination of cultural identities.}, language = {en} } @article{MaetzigVasishthEngelmannetal.2018, author = {M{\"a}tzig, Paul and Vasishth, Shravan and Engelmann, Felix and Caplan, David and Burchert, Frank}, title = {A computational investigation of sources of variability in sentence comprehension difficulty in aphasia}, series = {Topics in cognitive science}, volume = {10}, journal = {Topics in cognitive science}, number = {1}, publisher = {Wiley}, address = {Hoboken}, issn = {1756-8757}, doi = {10.1111/tops.12323}, pages = {161 -- 174}, year = {2018}, abstract = {We present a computational evaluation of three hypotheses about sources of deficit in sentence comprehension in aphasia: slowed processing, intermittent deficiency, and resource reduction. The ACT-R based Lewis and Vasishth (2005) model is used to implement these three proposals. Slowed processing is implemented as slowed execution time of parse steps; intermittent deficiency as increased random noise in activation of elements in memory; and resource reduction as reduced spreading activation. As data, we considered subject vs. object relative sentences, presented in a self-paced listening modality to 56 individuals with aphasia (IWA) and 46 matched controls. The participants heard the sentences and carried out a picture verification task to decide on an interpretation of the sentence. These response accuracies are used to identify the best parameters (for each participant) that correspond to the three hypotheses mentioned above. We show that controls have more tightly clustered (less variable) parameter values than IWA; specifically, compared to controls, among IWA there are more individuals with slow parsing times, high noise, and low spreading activation. We find that (a) individual IWA show differential amounts of deficit along the three dimensions of slowed processing, intermittent deficiency, and resource reduction, (b) overall, there is evidence for all three sources of deficit playing a role, and (c) IWA have a more variable range of parameter values than controls. An important implication is that it may be meaningless to talk about sources of deficit with respect to an abstract verage IWA; the focus should be on the individual's differential degrees of deficit along different dimensions, and on understanding the causes of variability in deficit between participants.}, language = {en} } @article{PratHajnyGrunewaldetal.2018, author = {Prat, Tomas and Hajny, Jakub and Grunewald, Wim and Vasileva, Mina and Molnar, Gergely and Tejos, Ricardo and Schmid, Markus and Sauer, Michael and Friml, Jiř{\´i}}, title = {WRKY23 is a component of the transcriptional network mediating auxin feedback on PIN polarity}, series = {PLoS Genetics : a peer-reviewed, open-access journal}, volume = {14}, journal = {PLoS Genetics : a peer-reviewed, open-access journal}, number = {1}, publisher = {PLoS}, address = {San Fransisco}, issn = {1553-7404}, doi = {10.1371/journal.pgen.1007177}, pages = {18}, year = {2018}, abstract = {Auxin is unique among plant hormones due to its directional transport that is mediated by the polarly distributed PIN auxin transporters at the plasma membrane. The canalization hypothesis proposes that the auxin feedback on its polar flow is a crucial, plant-specific mechanism mediating multiple self-organizing developmental processes. Here, we used the auxin effect on the PIN polar localization in Arabidopsis thaliana roots as a proxy for the auxin feedback on the PIN polarity during canalization. We performed microarray experiments to find regulators of this process that act downstream of auxin. We identified genes that were transcriptionally regulated by auxin in an AXR3/IAA17-and ARF7/ARF19-dependent manner. Besides the known components of the PIN polarity, such as PID and PIP5K kinases, a number of potential new regulators were detected, among which the WRKY23 transcription factor, which was characterized in more detail. Gain-and loss-of-function mutants confirmed a role for WRKY23 in mediating the auxin effect on the PIN polarity. Accordingly, processes requiring auxin-mediated PIN polarity rearrangements, such as vascular tissue development during leaf venation, showed a higher WRKY23 expression and required the WRKY23 activity. Our results provide initial insights into the auxin transcriptional network acting upstream of PIN polarization and, potentially, canalization-mediated plant development.}, language = {en} } @article{BayerlKrausNowaketal.2018, author = {Bayerl, Helmut and Kraus, Robert H. S. and Nowak, Carsten and Foerster, Daniel W. and Fickel, J{\"o}rns and K{\"u}hn, Ralph}, title = {Fast and cost-effective single nucleotide polymorphism (SNP) detection in the absence of a reference genome using semideep next-generation Random Amplicon Sequencing (RAMseq)}, series = {Molecular ecology resources}, volume = {18}, journal = {Molecular ecology resources}, number = {1}, publisher = {Wiley}, address = {Hoboken}, issn = {1755-098X}, doi = {10.1111/1755-0998.12717}, pages = {107 -- 117}, year = {2018}, abstract = {Biodiversity has suffered a dramatic global decline during the past decades, and monitoring tools are urgently needed providing data for the development and evaluation of conservation efforts both on a species and on a genetic level. However, in wild species, the assessment of genetic diversity is often hampered by the lack of suitable genetic markers. In this article, we present Random Amplicon Sequencing (RAMseq), a novel approach for fast and cost-effective detection of single nucleotide polymorphisms (SNPs) in nonmodel species by semideep sequencing of random amplicons. By applying RAMseq to the Eurasian otter (Lutra lutra), we identified 238 putative SNPs after quality filtering of all candidate loci and were able to validate 32 of 77 loci tested. In a second step, we evaluated the genotyping performance of these SNP loci in noninvasive samples, one of the most challenging genotyping applications, by comparing it with genotyping results of the same faecal samples at microsatellite markers. We compared (i) polymerase chain reaction (PCR) success rate, (ii) genotyping errors and (iii) Mendelian inheritance (population parameters). SNPs produced a significantly higher PCR success rate (75.5\% vs. 65.1\%) and lower mean allelic error rate (8.8\% vs. 13.3\%) than microsatellites, but showed a higher allelic dropout rate (29.7\% vs. 19.8\%). Genotyping results showed no deviations from Mendelian inheritance in any of the SNP loci. Hence, RAMseq appears to be a valuable tool for the detection of genetic markers in nonmodel species, which is a common challenge in conservation genetic studies.}, language = {en} } @article{MuehlbauerSchroederSchoelzel2018, author = {M{\"u}hlbauer, Felix and Schr{\"o}der, Lukas and Sch{\"o}lzel, Mario}, title = {Handling of transient and permanent faults in dynamically scheduled super-scalar processors}, series = {Microelectronics reliability}, volume = {80}, journal = {Microelectronics reliability}, publisher = {Elsevier}, address = {Oxford}, issn = {0026-2714}, doi = {10.1016/j.microrel.2017.11.021}, pages = {176 -- 183}, year = {2018}, abstract = {This article describes architectural extensions for a dynamically scheduled processor to enable three different operation modes, ranging from high-performance, to high-reliability. With minor extensions of the control path, the resources of the super-scalar data-path can be used either for high-performance execution, fail-safe-operation, or fault-tolerant-operation. Furthermore, the online error-correction capabilities are combined with reconfiguration techniques for permanent fault handling. This reconfiguration can take defective components out of operation permanently, and can be triggered on-demand during runtime, depending on the frequency of online corrected faults. A comprehensive fault simulation was carried out in order to evaluate hardware overhead, fault coverage and performance penalties of the proposed approach. Moreover, the impact of the permanent reconfiguration regarding the reliability and performance is investigated.}, language = {en} } @article{KrullWilbertHennemann2018, author = {Krull, Johanna and Wilbert, J{\"u}rgen and Hennemann, Thomas}, title = {Does social exclusion by classmates lead to behaviour problems and learning difficulties or vice versa?}, series = {European journal of special needs education}, volume = {33}, journal = {European journal of special needs education}, number = {2}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0885-6257}, doi = {10.1080/08856257.2018.1424780}, pages = {235 -- 253}, year = {2018}, abstract = {Social participation of pupils with special educational needs (SEN) is a central topic in the current inclusion debate. Numerous studies have shown that the risk of social exclusion is considerably higher for children with SEN compared to their peers without SEN, especially for pupils with behaviour problems (BP) or learning difficulties (LD). Since most of these studies are based on cross-sectional designs, there is a lack of knowledge regarding the direction of the effects. This leads to the question to what extent BP and LD have an impact on pupils' social position in the class and, vice versa, to what extent the social position has an effect on the development of BP and LD. To address these questions, we analysed sociometric data of 1244 primary school children. {\`E} A cross-lagged panel analysis was conducted. The results indicate that BP and LD in 1st grade lead to significantly less social acceptance by peers in 2nd grade but do not predict significantly higher social rejection. A directed influence of LD or BP on a higher social rejection cannot be found. Conversely, neither social acceptance nor social rejection at 1st grade has an influence on the development of BP or LD at grade two.}, language = {en} } @article{TejosRodriguezFurlanAdamowskietal.2018, author = {Tejos, Ricardo and Rodriguez-Furlan, Cecilia and Adamowski, Maciej and Sauer, Michael and Norambuena, Lorena and Friml, Jiri}, title = {PATELLINS are regulators of auxin-mediated PIN1 relocation and plant development in Arabidopsis thaliana}, series = {Journal of cell science}, volume = {131}, journal = {Journal of cell science}, number = {2}, publisher = {Company of Biologists Limited}, address = {Cambridge}, issn = {0021-9533}, doi = {10.1242/jcs.204198}, pages = {10}, year = {2018}, abstract = {Coordinated cell polarization in developing tissues is a recurrent theme in multicellular organisms. In plants, a directional distribution of the plant hormone auxin is at the core of many developmental programs. A feedback regulation of auxin on the polarized localization of PIN auxin transporters in individual cells has been proposed as a self-organizing mechanism for coordinated tissue polarization, but the molecular mechanisms linking auxin signalling to PIN-dependent auxin transport remain unknown. We used a microarray-based approach to find regulators of the auxin-induced PIN relocation in Arabidopsis thaliana root, and identified a subset of a family of phosphatidylinositol transfer proteins (PITPs), the PATELLINs (PATLs). Here, we show that PATLs are expressed in partially overlapping cell types in different tissues going through mitosis or initiating differentiation programs. PATLs are plasma membrane-associated proteins accumulated in Arabidopsis embryos, primary roots, lateral root primordia and developing stomata. Higher order patl mutants display reduced PIN1 repolarization in response to auxin, shorter root apical meristem, and drastic defects in embryo and seedling development. This suggests that PATLs play a redundant and crucial role in polarity and patterning in Arabidopsis.}, language = {en} } @article{BollierSicardLeblondetal.2018, author = {Bollier, Norbert and Sicard, Adrien and Leblond, Julie and Latrasse, David and Gonzalez, Nathalie and Gevaudant, Frederic and Benhamed, Moussa and Raynaud, Cecile and Lenhard, Michael and Chevalier, Christian and Hernould, Michel and Delmas, Frederic}, title = {At-MINI ZINC FINGER2 and Sl-INHIBITOR OF MERISTEM ACTIVITY, a Conserved Missing Link in the Regulation of Floral Meristem Termination in Arabidopsis and Tomato}, series = {The plant cell}, volume = {30}, journal = {The plant cell}, number = {1}, publisher = {American Society of Plant Physiologists}, address = {Rockville}, issn = {1040-4651}, doi = {10.1105/tpc.17.00653}, pages = {83 -- 100}, year = {2018}, abstract = {In angiosperms, the gynoecium is the last structure to develop within the flower due to the determinate fate of floral meristem (FM) stem cells. The maintenance of stem cell activity before its arrest at the stage called FM termination affects the number of carpels that develop. The necessary inhibition at this stage of WUSCHEL (WUS), which is responsible for stem cell maintenance, involves a two-step mechanism. Direct repression mediated by the MADS domain transcription factor AGAMOUS (AG), followed by indirect repression requiring the C2H2 zinc-finger protein KNUCKLES (KNU), allow for the complete termination of floral stem cell activity. Here, we show that Arabidopsis thaliana MINI ZINC FINGER2 (AtMIF2) and its homolog in tomato (Solanum lycopersicum), INHIBITOR OF MERISTEM ACTIVITY (SlIMA), participate in the FM termination process by functioning as adaptor proteins. AtMIF2 and SlIMA recruit AtKNU and SlKNU, respectively, to form a transcriptional repressor complex together with TOPLESS and HISTONE DEACETYLASE19. AtMIF2 and SlIMA bind to the WUS and SIWUS loci in the respective plants, leading to their repression. These results provide important insights into the molecular mechanisms governing (FM) termination and highlight the essential role of AtMIF2/SlIMA during this developmental step, which determines carpel number and therefore fruit size.}, language = {en} } @article{GeigerKocyan2018, author = {Geiger, Daniel L. and Kocyan, Alexander}, title = {Studies on Oberonia 3. Aberrant flowers and other floral modifications in the orchid genus Oberonia}, series = {Nordic Journal of botany}, volume = {36}, journal = {Nordic Journal of botany}, number = {1-2}, publisher = {Wiley}, address = {Hoboken}, issn = {0107-055X}, doi = {10.1111/njb.01699}, pages = {8}, year = {2018}, abstract = {Orchid flowers are amongst the most conspicuous attractions that plants have generated over evolutionary epochs. However, organ homology in particular of androecium and gynoecium of orchid flowers have been, and are still, the subject of long-term discussion. Studies of aberrant - teratologic - flowers have traditionally helped to clarify organ identity in orchids. We here present for the first time teratological flowers within the florally smallest and inconspicuous orchid genus Oberonia and illustrate them by light and scanning electron microscopy. Pseudopeloria with half of a lateral petal transformed into a lip was found in O. costeriana J.J.Sm. and O. mucronata (D.Don) Ormerod \& Seidenf. A supernumerary lip is known from O. mucronata. Oberonia rufilabris Lindl. is documented with multiple aberrations: triple gynostemium and a total of 10 tepals, twin flowers, and duplicate lips. We interpret these aberrations in light of known floral developmental and organ identity information.}, language = {en} } @article{KimShprits2018, author = {Kim, Kyung-Chan and Shprits, Yuri Y.}, title = {Survey of the Favorable Conditions for Magnetosonic Wave Excitation}, series = {Journal of geophysical research : Space physics}, volume = {123}, journal = {Journal of geophysical research : Space physics}, number = {1}, publisher = {American Geophysical Union}, address = {Washington}, issn = {2169-9380}, doi = {10.1002/2017JA024865}, pages = {400 -- 413}, year = {2018}, abstract = {The ratio of the proton ring velocity (VR) to the local Alfven speed (VA), in addition to proton ring distributions, plays a key factor in the excitation of magnetosonic waves at frequencies between the proton cyclotron frequency fcp and the lower hybrid resonance frequency fLHR in the Earth's magnetosphere. Here we investigate whether there is a statistically significant relationship between occurrences of proton rings and magnetosonic waves both outside and inside the plasmapause using particle and wave data from Van Allen Probe-A during the time period of October 2012 to December 2015. We also perform a statistical survey of the ratio of the ring energy (ER, corresponding to VR) to the Alfven energy (EA, corresponding to VA) to determine the favorable conditions under which magnetosonic waves in each of two frequency bands (fcp < f ≤ 0.5 fLHR and 0.5 fLHR < f < fLHR) can be excited. The results show that the magnetosonic waves in both frequency bands occur around the postnoon (12-18 magnetic local time, MLT) sector outside the plasmapause when ER is comparable to or lower than EA, and those in lower-frequency bands (fcp < f ≤ 0.5 fLHR) occur around the postnoon sector inside the plasmapause when ER/EA > ~9. However, there is one discrepancy between occurrences of proton rings and magnetosonic waves in low-frequency bands around the prenoon sector (6-12 MLT) outside the plasmapause, which suggests either that the waves may have propagated during active time from the postnoon sector after being excited during quiet time, or they may have locally excited in the prenoon sector during active time.}, language = {en} } @article{LuReichetzederPrehnetal.2018, author = {Lu, Yong-Ping and Reichetzeder, Christoph and Prehn, Cornelia and von Websky, Karoline and Slowinski, Torsten and Chen, You-Peng and Yin, Liang-Hong and Kleuser, Burkhard and Yang, Xue-Song and Adamski, Jerzy and Hocher, Berthold}, title = {Fetal serum metabolites are independently associated with Gestational diabetes mellitus}, series = {Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology}, volume = {45}, journal = {Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology}, number = {2}, publisher = {Karger}, address = {Basel}, issn = {1015-8987}, doi = {10.1159/000487119}, pages = {625 -- 638}, year = {2018}, abstract = {Background/Aims: Gestational diabetes (GDM) might be associated with alterations in the metabolomic profile of affected mothers and their offspring. Until now, there is a paucity of studies that investigated both, the maternal and the fetal serum metabolome in the setting of GDM. Mounting evidence suggests that the fetus is not just passively affected by gestational disease but might play an active role in it. Metabolomic studies performed in maternal blood and fetal cord blood could help to better discern distinct fetal from maternal disease interactions. Methods: At the time of birth, serum samples from mothers and newborns (cord blood samples) were collected and screened for 163 metabolites utilizing tandem mass spectrometry. The cohort consisted of 412 mother/child pairs, including 31 cases of maternal GDM. Results: An initial non-adjusted analysis showed that eight metabolites in the maternal blood and 54 metabolites in the cord blood were associated with GDM. After Benjamini-Hochberg (BH) procedure and adjustment for confounding factors for GDM, fetal phosphatidylcholine acyl-alkyl C 32:1 and proline still showed an independent association with GDM. Conclusions: This study found metabolites in cord blood which were associated with GDM, even after adjustment for established risk factors of GDM. To the best of our knowledge, this is the first study demonstrating an independent association between fetal serum metabolites and maternal GDM. Our findings might suggest a potential effect of the fetal metabolome on maternal GDM. (c) 2018 The Author(s) Published by S. Karger AG, Basel}, language = {en} } @article{LuReichetzederPrehnetal.2018, author = {Lu, Yong-Ping and Reichetzeder, Christoph and Prehn, Cornelia and Yin, Liang-Hong and Yun, Chen and Zeng, Shufei and Chu, Chang and Adamski, Jerzy and Hocher, Berthold}, title = {Cord blood Lysophosphatidylcholine 16:1 is positively associated with birth weight}, series = {Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology}, volume = {45}, journal = {Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology}, number = {2}, publisher = {Karger}, address = {Basel}, issn = {1015-8987}, doi = {10.1159/000487118}, pages = {614 -- 624}, year = {2018}, abstract = {Background/Aims: Impaired birth outcomes, like low birth weight, have consistently been associated with increased disease susceptibility to hypertension in later life. Alterations in the maternal or fetal metabolism might impact on fetal growth and influence birth outcomes. Discerning associations between the maternal and fetal metabolome and surrogate parameters of fetal growth could give new insight into the complex relationship between intrauterine conditions, birth outcomes, and later life disease susceptibility. Methods: Using flow injection tandem mass spectrometry, targeted metabolomics was performed in serum samples obtained from 226 mother/child pairs at delivery. Associations between neonatal birth weight and concentrations of 163 maternal and fetal metabolites were analyzed. Results: After FDR adjustment using the Benjamini-Hochberg procedure lysophosphatidylcholines (LPC) 14:0, 16:1, and 18:1 were strongly positively correlated with birth weight. In a stepwise linear regression model corrected for established confounding factors of birth weight, LPC 16: 1 showed the strongest independent association with birth weight (CI: 93.63 - 168.94; P = 6.94x10(-11)). The association with birth weight was stronger than classical confounding factors such as offspring sex (CI: - 258.81- -61.32; P = 0.002) and maternal smoking during pregnancy (CI: -298.74 - -29.51; P = 0.017). Conclusions: After correction for multiple testing and adjustment for potential confounders, LPC 16:1 showed a very strong and independent association with birth weight. The underlying molecular mechanisms linking fetal LPCs with birth weight need to be addressed in future studies. (c) 2018 The Author(s) Published by S. Karger AG, Basel}, language = {en} } @article{SmithBookhagen2018, author = {Smith, Taylor and Bookhagen, Bodo}, title = {Changes in seasonal snow water equivalent distribution in High Mountain Asia (1987 to 2009)}, series = {Science Advances}, volume = {4}, journal = {Science Advances}, number = {1}, publisher = {American Assoc. for the Advancement of Science}, address = {Washington}, issn = {2375-2548}, doi = {10.1126/sciadv.1701550}, pages = {8}, year = {2018}, abstract = {Snow meltwaters account for most of the yearly water budgets of many catchments in High Mountain Asia (HMA). We examine trends in snow water equivalent (SWE) using passive microwave data (1987 to 2009). We find an overall decrease in SWE in HMA, despite regions of increased SWE in the Pamir, Kunlun Shan, Eastern Himalaya, and Eastern Tien Shan. Although the average decline in annual SWE across HMA (contributing area, 2641 x 10(3) km(2)) is low (average, -0.3\%), annual SWE losses conceal distinct seasonal and spatial heterogeneities across the study region. For example, the Tien Shan has seen both strong increases in winter SWE and sharp declines in spring and summer SWE. In the majority of catchments, the most negative SWE trends are found in mid-elevation zones, which often correspond to the regions of highest snow-water storage and are somewhat distinct from glaciated areas. Negative changes in SWE storage in these mid-elevation zones have strong implications for downstream water availability.}, language = {en} } @article{HuschekBoenickMerkeletal.2018, author = {Huschek, Gerd and B{\"o}nick, Josephine and Merkel, Dietrich and Huschek, Doreen and Rawel, Harshadrai Manilal}, title = {Authentication of leguminous-based products by targeted biomarkers using high resolution time of flight mass spectrometry}, series = {LWT - food science and technology : an official journal of the Swiss Society of Food Science and Technology (SGLWT/SOSSTA) and the International Union of Food Science and Technology (IUFoST)}, volume = {90}, journal = {LWT - food science and technology : an official journal of the Swiss Society of Food Science and Technology (SGLWT/SOSSTA) and the International Union of Food Science and Technology (IUFoST)}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0023-6438}, doi = {10.1016/j.lwt.2017.12.034}, pages = {164 -- 171}, year = {2018}, abstract = {A growing number of health-conscious individuals supplements their diet with protein-rich plant-based products to reduce their meat consumption. Analytical methods are needed to authenticate these new vegetarian products not only for the correct labelling of ingredients according to European legislation but also to discourage food fraud. This paper presents new biomarkers for a targeted proteomics LC-MS/MS work-flow that can simultaneously prove the presence/absence of garden pea, a protein-rich legume, meat and honey and quantify their content in processed vegan food. We show a novel rapid strategy to identify biomarkers for species authentication and the steps for the multi-parameter LC-MS/MS method validation and quantification. A high resolution triple time of flight mass spectrometer (HRMS) with SWATH Acquisition was used for the rapid discovery of all measurable trypsin-digested proteins in the individual ingredients. From these proteins, species-selective biomarkers were identified with BLAST and Skyline. Vicilin and convicilin (UniProt: D3VND9, Q9M3X6) allow pea authentication with regard to other legume species. Myostatin (UniProt: 018831) is a single biomarker for all meat types. For honey, we identified three selective proteins (UniProt: C6K481, C6K482, Q3L6329). The final LC-MS/MS method can identity and quantify these markers simultaneously. Quantification occurs via external matrix calibration.}, language = {en} } @article{HanneforthMalettiQuernheim2018, author = {Hanneforth, Thomas and Maletti, Andreas and Quernheim, Daniel}, title = {Pushing for weighted tree automata}, series = {Logical Methods in Computer Science}, volume = {14}, journal = {Logical Methods in Computer Science}, number = {1}, publisher = {Logical Methods in Computer Science E V}, address = {Braunschweig}, issn = {1860-5974}, doi = {10.23638/LMCS-14(1:5)2018}, pages = {16}, year = {2018}, abstract = {A weight normalization procedure, commonly called pushing, is introduced for weighted tree automata (wta) over commutative semifields. The normalization preserves the recognized weighted tree language even for nondeterministic wta, but it is most useful for bottom-up deterministic wta, where it can be used for minimization and equivalence testing. In both applications a careful selection of the weights to be redistributed followed by normalization allows a reduction of the general problem to the corresponding problem for bottom-up deterministic unweighted tree automata. This approach was already successfully used by Mohri and Eisner for the minimization of deterministic weighted string automata. Moreover, the new equivalence test for two wta M and M′ runs in time O((|M|+|M′|)⋅log(|Q|+|Q′|)), where Q and Q′ are the states of M and M′, respectively, which improves the previously best run-time O(|M|⋅|M′|).}, language = {en} } @article{KuhlmannBogumil2018, author = {Kuhlmann, Sabine and Bogumil, J{\"o}rg}, title = {Performance measurement and benchmarking as "reflexive institutions" for local governments}, series = {International journal of public sector management}, volume = {31}, journal = {International journal of public sector management}, number = {4}, publisher = {Emerald Group Publishing Limited}, address = {Bingley}, issn = {0951-3558}, doi = {10.1108/IJPSM-01-2017-0004}, pages = {543 -- 562}, year = {2018}, abstract = {Purpose The purpose of this paper is to discuss different approaches of performance measurement and benchmarking as reflexive institutions for local governments in England, Germany and Sweden from a comparative perspective. Design/methodology/approach These three countries have been selected because they represent typical (most different) cases of European local government systems and reforms. The existing theories on institutional reflexivity point to the potential contribution of benchmarking to public sector innovation and organizational learning. Based on survey findings, in-depth case studies, interviews and document analyses in these three countries, the paper addresses the major research question as to what extent and why benchmarking regimes vary across countries. It derives hypotheses about the impacts of benchmarking on institutional learning and innovation. Findings The outcomes suggest that the combination of three key features of benchmarking, namely - obligation, sanctions and benchmarking authority - in conjunction with country-specific administrative context conditions and local actor constellations - influences the impact of benchmarking as a reflexive institution. Originality/value It is shown in the paper that compulsory benchmarking on its own does not lead to reflexivity and learning, but that there is a need for autonomy and leeway for local actors to cope with benchmarking results. These findings are relevant because policy makers must decide upon the specific governance mix of benchmarking exercises taking their national and local contexts into account if they want them to promote institutional learning and innovation.}, language = {en} } @article{LenkeitSchwippertKnigge2018, author = {Lenkeit, Jenny and Schwippert, Knut and Knigge, Michel}, title = {Configurations of multiple disparities in reading performance}, series = {Assessment in education : principles, policy \& practice}, volume = {25}, journal = {Assessment in education : principles, policy \& practice}, number = {1}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0969-594X}, doi = {10.1080/0969594X.2017.1309352}, pages = {52 -- 86}, year = {2018}, abstract = {Research provides evidence that gender, immigrant background and socio-economic characteristics present multiple disadvantaging characteristics that change their relative importance and configurations over time. When evaluating inequalities researchers tend to focus on one particular aspect and often use composite measures when evaluating socio-economic characteristics. Neither can fully represent the complexity of students' various disadvantaging characteristics, which have autonomous associations with attainment and with each other. This paper investigates how the relative importance and configurations of different disadvantaging factors have changed over time to form educational inequalities and how these changes differ across countries. Data from five PISA cycles (2000-2012) for France, Germany, Sweden and the United Kingdom are used and configurations of gender, immigration background, parents' occupational and educational levels, and the number of books at home evaluated. Results enable us to relate changes (or lack thereof) in configurations of disadvantaging factors to recent reforms targeted at reducing educational inequality after the first PISA results.}, language = {en} } @article{FyndanisArfaniVarlokostaetal.2018, author = {Fyndanis, Valantis and Arfani, Dimitra and Varlokosta, Spyridoula and Burgio, Francesca and Maculan, Anna and Miceli, Gabriele and Arcara, Giorgio and Palla, Fabio and Cagnin, Annachiara and Papageorgiou, Sokratis G. and Semenza, Carlo}, title = {Morphosyntactic production in Greek- and Italian-speaking individuals with probable Alzheimer's disease}, series = {Aphasiology : an international, interdisciplinary journal}, volume = {32}, journal = {Aphasiology : an international, interdisciplinary journal}, number = {1}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0268-7038}, doi = {10.1080/02687038.2017.1358352}, pages = {61 -- 87}, year = {2018}, abstract = {Background: In probable Alzheimer's disease (AD), different memory systems, executive functioning, visuospatial recognition, and language are impaired. Regarding the latter, only a few studies have investigated morphosyntactic production thus far. Aims: This study, which is a follow-up on Fyndanis, V., Manouilidou, C., Koufou, E., Karampekios, S., and Tsapakis, E. M. (2013). Agrammatic patterns in Alzheimer's disease: Evidence from tense, agreement, and aspect. Aphasiology, 27, 178-200. doi:10.1080/02687038.2012.705814, investigates whether verb-related morphosyntactic production is (selectively) impaired in AD focusing on two highly inflected languages, Greek and Italian. The morphosyntactic phenomena explored are subject-verb Agreement, Tense/Time Reference, and Mood. Focusing on these phenomena allows us to investigate if recent hypotheses, originally developed in aphasia research, can also capture results related to AD. We tested the hypotheses discussed in Fyndanis, V., Manouilidou, C., Koufou, E., Karampekios, S., and Tsapakis, E. M. (2013). Agrammatic patterns in Alzheimer's disease: Evidence from tense, agreement, and aspect. Aphasiology, 27, 178-200. doi:10.1080/02687038.2012.705814, that is, the Interpretable Features' Impairment Hypothesis (IFIH) (e.g., Fyndanis, V., Varlokosta, S., \& Tsapkini, K. 2012. Agrammatic production: Interpretable features and selective impairment in verb inflection. Lingua, 122, 1134-1147. doi:10.1016/j.lingua.2012.05.004) and the PAst DIscourse LInking Hypothesis (PADILIH; Bastiaanse, R., Bamyaci, E., Hsu, C., Lee, J., Yarbay Duman, T., \& Thompson, C. K. 2011. Time reference in agrammatic aphasia: A cross-linguistic study. Journal of Neurolinguistics, 24, 652-673. doi:10.1016/j.jneuroling.2011.07.001). Methods \& Procedures: Two sentence completion tasks testing the production of subject-verb Agreement, Tense/Time Reference, and Mood were administered to 16 Greek-speaking and 10 Italian-speaking individuals with mild-to-moderate AD, as well as to 16 Greek-speaking and 11 Italian-speaking neurologically intact individuals who were matched with the participants with AD on age and education. Mixed-effects models were fitted to the data. Outcomes \& Results: At the group level, both the Greek and Italian participants with AD performed worse than the controls. Both AD groups revealed selective patterns of morphosyntactic production (Greek: Agreement/Mood > Time Reference; Italian: Agreement > Time Reference > Mood). Past Reference and Future Reference did not dissociate in either of the two AD groups. Nevertheless, in all four participants with AD who showed dissociations, Past Reference was more impaired than Future Reference. Conclusions: The results indicate that the production of verb-related morphosyntactic categories can be impaired in mild-to-moderate AD. The different patterns observed in the two languages are partly attributable to the different way these languages encode Mood. The group results (of both the Greek-and Italian-speaking participants with AD) do not lend support to the PADILIH, whereas only the results of the Italian AD group are fully consistent with the IFIH. However, the individual data are consistent with the PADILIH, and the IFIH is informed by the present data and modified accordingly so that it can capture cross-linguistic patterns of morphosyntactic impairment.}, language = {en} } @article{BuerkiFoschiniViebahnRacineetal.2018, author = {B{\"u}rki-Foschini, Audrey Damaris and Viebahn, Malte Clemens and Racine, Isabelle and Mabut, Cassandre and Spinelli, Elsa}, title = {Intrinsic advantage for canonical forms in spoken word recognition}, series = {Language, cognition and neuroscience}, volume = {33}, journal = {Language, cognition and neuroscience}, number = {4}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {2327-3798}, doi = {10.1080/23273798.2017.1388412}, pages = {494 -- 511}, year = {2018}, abstract = {In connected speech, many words are produced with a pronunciation that differs from the canonical form. How the speech recognition system deals with this variation is a fundamental issue in the language processing literature. The present study examines the roles of variant type, variant frequency, and context in the processing of French words with a canonical (schwa variant, e.g. semaine "week") and a non-canonical pronunciation (no-schwa variant, s'maine). It asks whether the processing of canonical pronunciations is faster than the processing of non-canonical ones. Results of three lexical decision experiments reveal that more frequent variants are recognised more quickly, and that there is no advantage for canonical forms once variant frequency is accounted for. Two of these experiments further failed to find evidence that the context in which the words are presented modulate the effect of variant type. These findings are discussed in the light of spoken word recognition models.}, language = {en} } @article{ChangSchulze2018, author = {Chang, Der-Chen and Schulze, Bert-Wolfgang}, title = {Corner spaces and Mellin quantization}, series = {Journal of nonlinear and convex analysis : an international journal}, volume = {19}, journal = {Journal of nonlinear and convex analysis : an international journal}, number = {2}, publisher = {Yokohama Publishers}, address = {Yokohama}, issn = {1345-4773}, pages = {179 -- 195}, year = {2018}, abstract = {Manifolds with corners in the present investigation are non-smooth configurations - specific stratified spaces - with an incomplete metric such as cones, manifolds with edges, or corners of piecewise smooth domains in Euclidean space. We focus here on operators on such "corner manifolds" of singularity order <= 2, acting in weighted corner Sobolev spaces. The corresponding corner degenerate pseudo-differential operators are formulated via Mellin quantizations, and they also make sense on infinite singular cones.}, language = {en} } @article{UrbachFay2018, author = {Urbach, Tina and Fay, Doris}, title = {When proactivity produces a power struggle}, series = {European journal of work and organizational psychology : the official journal of The European Association of Work and Organizational Psychology}, volume = {27}, journal = {European journal of work and organizational psychology : the official journal of The European Association of Work and Organizational Psychology}, number = {2}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {1359-432X}, doi = {10.1080/1359432X.2018.1435528}, pages = {280 -- 295}, year = {2018}, abstract = {Previous research informs us about facilitators of employees' promotive voice. Yet little is known about what determines whether a specific idea for constructive change brought up by an employee will be approved or rejected by a supervisor. Drawing on interactionist theories of motivation and personality, we propose that a supervisor will be least likely to support an idea when it threatens the supervisor's power motive, and when it is perceived to serve the employee's own striving for power. The prosocial versus egoistic intentions attributed to the idea presenter are proposed to mediate the latter effect. We conducted three scenario-based studies in which supervisors evaluated fictitious ideas voiced by employees that - if implemented - would have power-related consequences for them as a supervisor. Results show that the higher a supervisors' explicit power motive was, the less likely they were to support a power-threatening idea (Study 1, N = 60). Moreover, idea support was less likely when this idea was proposed by an employee that was described as high (rather than low) on power motivation (Study 2, N = 79); attributed prosocial intentions mediated this effect. Study 3 (N = 260) replicates these results.}, language = {en} } @article{Schwarz2018, author = {Schwarz, Anja}, title = {Schomburgk's Chook}, series = {Postcolonial Studies}, volume = {21}, journal = {Postcolonial Studies}, number = {1}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {1368-8790}, doi = {10.1080/13688790.2018.1434749}, pages = {20 -- 34}, year = {2018}, abstract = {Focusing on the politics of museums, collections and the untold stories of the scientific 'specimens' that travelled between Germany and Australia, this article reconstructs the historical, interpersonal and geopolitical contexts that made it possible for the stuffed skin of an Australian malleefowl to become part of the collections of Berlin's Museum f{\"u}r Naturkunde. The author enquires into the kinds of contexts that are habitually considered irrelevant when a specimen of natural history is treated as an object of taxonomic information only. In case of this particular specimen human and non-human history become entangled in ways that link the fate of this one small Australian bird to the German revolutionary generation of 1848, to Germany's nineteenth-century colonial aspirations, to settler-Indigenous relations, to the cruel realities that underpinned the production of scientific knowledge in colonial Australia, and to a present-day interest in reconstructing Indigenous knowledges.}, language = {en} } @article{Eckstein2018, author = {Eckstein, Lars}, title = {Recollecting bones}, series = {Postcolonial Studies}, volume = {21}, journal = {Postcolonial Studies}, number = {1}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {1368-8790}, doi = {10.1080/13688790.2018.1435146}, pages = {6 -- 19}, year = {2018}, abstract = {This article critically engages with the different politics of memory involved in debates over the restitution of Indigenous Australian ancestral remains stolen by colonial actors in the nineteenth and early twentieth centuries and brought to Berlin in the name of science. The debates crystallise how deeply divided German scientific discourses still are over the question of whether the historical and moral obligations of colonial injustice should be accepted or whether researchers should continue to profess scientific 'disinterest'. The debates also reveal an almost unanimous disavowal of Indigenous Australian knowledges and mnemonic conceptions across all camps. The bitter ironies of this disavowal become evident when Indigenous Australian quests for the remains of their ancestral dead lost in the limbo of German scientific collections are juxtaposed with white Australian (fictional) quests for the remains of Ludwig Leichhardt, lost in the Australian interior.}, language = {en} } @article{Selting2018, author = {Selting, Margret}, title = {For Charles Goodwin, Chuck}, series = {Co-operative engagements in intertwined semiosis: essays in honour of Charles Goodwin}, volume = {19}, journal = {Co-operative engagements in intertwined semiosis: essays in honour of Charles Goodwin}, publisher = {University of Tartu Press}, address = {Tartu}, isbn = {978-9949-77-688-7}, issn = {1406-4278}, pages = {361 -- 362}, year = {2018}, abstract = {This appreciation will not be a testimonial to Chuck's numerous publications and research achievements - I am sure that others will have a lot to say about those. Instead, I will say something about how I personally experienced and think of him, as a researcher personality, based on the limited time and the few occasions that we have had together.}, language = {en} } @article{Muschalla2018, author = {Muschalla, Beate}, title = {A concept of psychological work capacity demands}, series = {Work : a journal of prevention, assessment \& rehabilitation}, volume = {59}, journal = {Work : a journal of prevention, assessment \& rehabilitation}, number = {3}, publisher = {IOS Press}, address = {Amsterdam}, issn = {1051-9815}, doi = {10.3233/WOR-182691}, pages = {375 -- 386}, year = {2018}, abstract = {BACKGROUND: Work capacity demands are a concept to describe which psychological capacities are required in a job. Assessing psychological work capacity demands is of specific importance when mental health problems at work endanger work ability. Exploring psychological work capacity demands is the basis for mental hazard analysis or rehabilitative action, e.g. in terms of work adjustment. OBJECTIVE: This is the first study investigating psychological work capacity demands in rehabilitation patients with and without mental disorders. METHODS: A structured interview on psychological work capacity demands (Mini-ICF-Work; Muschalla, 2015; Linden et al., 2015) was done with 166 rehabilitation patients of working age. All interviews were done by a state-licensed socio-medically trained psychotherapist. Inter-rater-reliability was assessed by determining agreement in independent co-rating in 65 interviews. For discriminant validity purposes, participants filled in the Short Questionnaire for Work Analysis (KFZA, Prumper et al., 1994). RESULTS: In different professional fields, different psychological work capacity demands were of importance. The Mini-ICF-Work capacity dimensions reflect different aspects than the KFZA. Patients with mental disorders were longer on sick leave and had worse work ability prognosis than patients without mental disorders, although both groups reported similar work capacity demands. CONCLUSIONS: Psychological work demands - which are highly relevant for work ability prognosis and work adjustment processes - can be explored and differentiated in terms of psychological capacity demands.}, language = {en} } @article{GanghofEppnerPoerschke2018, author = {Ganghof, Steffen and Eppner, Sebastian and P{\"o}rschke, Alexander}, title = {Semi-parliamentary government in perspective}, series = {Australian Journal of Political Science}, volume = {53}, journal = {Australian Journal of Political Science}, number = {2}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {1036-1146}, doi = {10.1080/10361146.2018.1451488}, pages = {264 -- 269}, year = {2018}, abstract = {The article responds to four commentaries on the concept of semi-parliamentary government and its application to Australian bicameralism. It highlights four main points: (1) Our preferred typology is not more 'normative' than existing approaches, but applies the criterion of 'direct election' equally to executive and legislature; (2) While the evolution of semi-parliamentary government had contingent elements, it plausibly also reflects the 'equilibrium' nature of certain institutional configurations; (3) The idea that a pure parliamentary system with pure proportional representation has absolute normative priority over 'instrumentalist' concerns about cabinet stability, identifiability and responsibility is questionable; and (4) The reforms we discuss may be unlikely to occur in Australia, but deserve consideration by scholars and institutional reformers in other democratic systems.}, language = {en} } @article{GanghofEppnerPoerschke2018, author = {Ganghof, Steffen and Eppner, Sebastian and P{\"o}rschke, Alexander}, title = {Australian bicameralism as semi-parliamentarism}, series = {Australian Journal of Political Science}, volume = {53}, journal = {Australian Journal of Political Science}, number = {2}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {1036-1146}, doi = {10.1080/10361146.2018.1451487}, pages = {211 -- 233}, year = {2018}, abstract = {The article analyses the type of bicameralism we find in Australia as a distinct executive-legislative system - a hybrid between parliamentary and presidential government - which we call 'semi-parliamentary government'. We argue that this hybrid presents an important and underappreciated alternative to pure parliamentary government as well as presidential forms of the power-separation, and that it can achieve a certain balance between competing models or visions of democracy. We specify theoretically how the semi-parliamentary separation of powers contributes to the balancing of democratic visions and propose a conceptual framework for comparing democratic visions. We use this framework to locate the Australian Commonwealth, all Australian states and 22 advanced democratic nation-states on a two-dimensional empirical map of democratic patterns for the period from 1995 to 2015.}, language = {en} } @article{MuivaMutisyaAtilawHeydenreichetal.2018, author = {Muiva-Mutisya, Lois M. and Atilaw, Yoseph and Heydenreich, Matthias and Koch, Andreas and Akala, Hoseah M. and Cheruiyot, Agnes C. and Brown, Matthew L. and Irungu, Beatrice and Okalebo, Faith A. and Derese, Solomon and Mutai, Charles and Yenesew, Abiy}, title = {Antiplasmodial prenylated flavanonols from Tephrosia subtriflora}, series = {Natural Product Research}, volume = {32}, journal = {Natural Product Research}, number = {12}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {1478-6419}, doi = {10.1080/14786419.2017.1353510}, pages = {1407 -- 1414}, year = {2018}, abstract = {The CH2Cl2/MeOH (1:1) extract of the aerial parts of Tephrosia subtriflora afforded a new flavanonol, named subtriflavanonol (1), along with the known flavanone spinoflavanone B, and the known flavanonols MS-II (2) and mundulinol. The structures were elucidated by the use of NMR spectroscopy and mass spectrometry. The absolute configuration of the flavanonols was determined based on quantum chemical ECD calculations. In the antiplasmodial assay, compound 2 showed the highest activity against chloroquine-sensitive Plasmodiumfalciparum reference clones (D6 and 3D7), artemisinin-sensitive isolate (F32-TEM) as well as field isolate (KSM 009) with IC50 values 1.4-4.6M without significant cytotoxicity against Vero and HEp2 cell lines (IC50>100M). The new compound (1) showed weak antiplasmodial activity, IC50 12.5-24.2M, but also showed selective anticancer activity against HEp2 cell line (CC50 16.9M). [GRAPHICS] .}, language = {en} } @article{BurmesterSauermannSpaleketal.2018, author = {Burmester, Juliane and Sauermann, Antje and Spalek, Katharina and Wartenburger, Isabell}, title = {Sensitivity to salience}, series = {Language, cognition and neuroscience}, volume = {33}, journal = {Language, cognition and neuroscience}, number = {6}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {2327-3798}, doi = {10.1080/23273798.2018.1428758}, pages = {784 -- 801}, year = {2018}, abstract = {Sentence comprehension is optimised by indicating entities as salient through linguistic (i.e., information-structural) or visual means. We compare how salience of a depicted referent due to a linguistic (i.e., topic status) or visual cue (i.e., a virtual person's gaze shift) modulates sentence comprehension in German. We investigated processing of sentences with varying word order and pronoun resolution by means of self-paced reading and an antecedent choice task, respectively. Our results show that linguistic as well as visual salience cues immediately speeded up reading times of sentences mentioning the salient referent first. In contrast, for pronoun resolution, linguistic and visual cues modulated antecedent choice preferences less congruently. In sum, our findings speak in favour of a significant impact of linguistic and visual salience cues on sentence comprehension, substantiating that salient information delivered via language as well as the visual environment is integrated in the current mental representation of the discourse.}, language = {en} } @article{GomezHartung2018, author = {Gomez, Christophe and Hartung, Niklas}, title = {Stochastic and deterministic models for the metastatic emission process}, series = {Cancer Systems Biology}, volume = {1711}, journal = {Cancer Systems Biology}, publisher = {Humana Press Inc.}, address = {Totowa}, isbn = {978-1-4939-7493-1}, issn = {1064-3745}, doi = {10.1007/978-1-4939-7493-1_10}, pages = {193 -- 224}, year = {2018}, abstract = {Although the detection of metastases radically changes prognosis of and treatment decisions for a cancer patient, clinically undetectable micrometastases hamper a consistent classification into localized or metastatic disease. This chapter discusses mathematical modeling efforts that could help to estimate the metastatic risk in such a situation. We focus on two approaches: (1) a stochastic framework describing metastatic emission events at random times, formalized via Poisson processes, and (2) a deterministic framework describing the micrometastatic state through a size-structured density function in a partial differential equation model. Three aspects are addressed in this chapter. First, a motivation for the Poisson process framework is presented and modeling hypotheses and mechanisms are introduced. Second, we extend the Poisson model to account for secondary metastatic emission. Third, we highlight an inherent crosslink between the stochastic and deterministic frameworks and discuss its implications. For increased accessibility the chapter is split into an informal presentation of the results using a minimum of mathematical formalism and a rigorous mathematical treatment for more theoretically interested readers.}, language = {en} } @article{AsariWardinski2018, author = {Asari, Seiki and Wardinski, Ingo}, title = {Interannual fluctuations of the core angular momentum inferred from geomagnetic field models}, series = {Magnetic Fields in the Solar System : Planets, Moons and Solar Wind Interactions}, volume = {448}, journal = {Magnetic Fields in the Solar System : Planets, Moons and Solar Wind Interactions}, publisher = {Springer}, address = {Dordrecht}, isbn = {978-3-319-64292-5}, issn = {0067-0057}, doi = {10.1007/978-3-319-64292-5_4}, pages = {111 -- 123}, year = {2018}, language = {en} } @article{KerstingKuhlmann2018, author = {Kersting, Norbert and Kuhlmann, Sabine}, title = {Sub-municipal Units in Germany}, series = {Sub-municipal Units in Germany: Municipal and Metropolitan Districts}, journal = {Sub-municipal Units in Germany: Municipal and Metropolitan Districts}, publisher = {Palgrave}, address = {Basingstoke}, isbn = {978-3-319-64725-8}, doi = {10.1007/978-3-319-64725-8_5}, pages = {93 -- 118}, year = {2018}, abstract = {Sub-municipal units (SMUs) in Germany differ in German L{\"a}nder. In Berlin, Hamburg and M{\"u}nchen Metropole Districts fulfill a number of quasi-municipal self-government rights and functions. They have their own budget and strong councils, as well as mayors. In all other L{\"a}nder, most sub-municipal councils were subordinated under the municipal council and directly elected mayor heading the administration. SMUs were introduced as a kind of compensation with different territorial reforms in the 1970s. Although directly elected, sub-municipal councilors are weak, and their advisory role competes with other newly established advisory boards. Here the focus remains on traffic and town planning. Some sub-municipal councils fulfill smaller administrative functions and become more relevant and important in recent decentralization strategies of neighborhood development.}, language = {en} } @article{ReinhardtLierschAbdeladhimetal.2018, author = {Reinhardt, Julia and Liersch, Stefan and Abdeladhim, Mohamed Arbi and Diallo, Mori and Dickens, Chris and Fournet, Samuel and Hattermann, Fred and Kabaseke, Clovis and Muhumuza, Moses and Mul, Marloes L. and Pilz, Tobias and Otto, Ilona M. and Walz, Ariane}, title = {Systematic evaluation of scenario assessments supporting sustainable integrated natural resources management}, series = {Ecology and society : a journal of integrative science for resilience and sustainability}, volume = {23}, journal = {Ecology and society : a journal of integrative science for resilience and sustainability}, number = {1}, publisher = {Resilience Alliance}, address = {Wolfville}, issn = {1708-3087}, doi = {10.5751/ES-09728-230105}, pages = {34}, year = {2018}, abstract = {Scenarios have become a key tool for supporting sustainability research on regional and global change. In this study we evaluate four regional scenario assessments: first, to explore a number of research challenges related to sustainability science and, second, to contribute to sustainability research in the specific case studies. The four case studies used commonly applied scenario approaches that are (i) a story and simulation approach with stakeholder participation in the Oum Zessar watershed, Tunisia, (ii) a participatory scenario exploration in the Rwenzori region, Uganda, (iii) a model-based prepolicy study in the Inner Niger Delta, Mali, and (iv) a model coupling-based scenario analysis in upper Thukela basin, South Africa. The scenario assessments are evaluated against a set of known challenges in sustainability science, with each challenge represented by two indicators, complemented by a survey carried out on the perception of the scenario assessments within the case study regions. The results show that all types of scenario assessments address many sustainability challenges, but that the more complex ones based on story and simulation and model coupling are the most comprehensive. The study highlights the need to investigate abrupt system changes as well as governmental and political factors as important sources of uncertainty. For an in-depth analysis of these issues, the use of qualitative approaches and an active engagement of local stakeholders are suggested. Studying ecological thresholds for the regional scale is recommended to support research on regional sustainability. The evaluation of the scenario processes and outcomes by local researchers indicates the most transparent scenario assessments as the most useful. Focused, straightforward, yet iterative scenario assessments can be very relevant by contributing information to selected sustainability problems.}, language = {en} } @article{VormoorHeistermannBronstertetal.2018, author = {Vormoor, Klaus Josef and Heistermann, Maik and Bronstert, Axel and Lawrence, Deborah}, title = {Hydrological model parameter (in)stability}, series = {Hydrological sciences journal = Journal des sciences hydrologiques}, volume = {63}, journal = {Hydrological sciences journal = Journal des sciences hydrologiques}, number = {7}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0262-6667}, doi = {10.1080/02626667.2018.1466056}, pages = {991 -- 1007}, year = {2018}, abstract = {This paper investigates the transferability of calibrated HBV model parameters under stable and contrasting conditions in terms of flood seasonality and flood generating processes (FGP) in five Norwegian catchments with mixed snowmelt/rainfall regimes. We apply a series of generalized (differential) split-sample tests using a 6-year moving window over (i) the entire runoff observation periods, and (ii) two subsets of runoff observations distinguished by the seasonal occurrence of annual maximum floods during either spring or autumn. The results indicate a general model performance loss due to the transfer of calibrated parameters to independent validation periods of -5 to -17\%, on average. However, there is no indication that contrasting flood seasonality exacerbates performance losses, which contradicts the assumption that optimized parameter sets for snowmelt-dominated floods (during spring) perform particularly poorly on validation periods with rainfall-dominated floods (during autumn) and vice versa.}, language = {en} } @article{ClassKoehlerKrawietz2018, author = {Class, Fabian and K{\"o}hler, Ulrich and Krawietz, Marian}, title = {The Potsdam Grievance Statistics File}, series = {Historical Methods}, volume = {51}, journal = {Historical Methods}, number = {2}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0161-5440}, doi = {10.1080/01615440.2018.1429970}, pages = {92 -- 114}, year = {2018}, abstract = {The newly collected Potsdam Grievance Statistics File (PGSF) holds data on the number and topics of grievances (Eingaben) that were addressed to local authorities of the German Democratic Republic (GDR) in the years 1970 to 1989. The PGSF allows quantitative analyses on topics such as participation, quality of life, and value change in the German Democratic Republic. This paper introduces the concepts of the data set and discusses the validity of its contents.}, language = {en} } @article{UtechtKlamroth2018, author = {Utecht, Manuel Martin and Klamroth, Tillmann}, title = {Local resonances in STM manipulation of chlorobenzene on Si(111)-7x7}, series = {Molecular physics}, volume = {116}, journal = {Molecular physics}, number = {13}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0026-8976}, doi = {10.1080/00268976.2018.1442939}, pages = {1687 -- 1696}, year = {2018}, abstract = {Hot localised charge carriers on the Si(111)-7x7 surface are modelled by small charged clusters. Such resonances induce non-local desorption, i.e. more than 10 nm away from the injection site, of chlorobenzene in scanning tunnelling microscope experiments. We used such a cluster model to characterise resonance localisation and vibrational activation for positive and negative resonances recently. In this work, we investigate to which extent the model depends on details of the used cluster or quantum chemistry methods and try to identify the smallest possible cluster suitable for a description of the neutral surface and the ion resonances. Furthermore, a detailed analysis for different chemisorption orientations is performed. While some properties, as estimates of the resonance energy or absolute values for atomic changes, show such a dependency, the main findings are very robust with respect to changes in the model and/or the chemisorption geometry. [GRAPHICS] .}, language = {en} } @article{WatanabeTohgeBalazadehetal.2018, author = {Watanabe, Mutsumi and Tohge, Takayuki and Balazadeh, Salma and Erban, Alexander and Giavalisco, Patrick and Kopka, Joachim and Mueller-Roeber, Bernd and Fernie, Alisdair R. and Hoefgen, Rainer}, title = {Comprehensive Metabolomics Studies of Plant Developmental Senescence}, series = {Plant Senescence: Methods and Protocols}, volume = {1744}, journal = {Plant Senescence: Methods and Protocols}, publisher = {Humana Press}, address = {Totowa}, isbn = {978-1-4939-7672-0}, issn = {1064-3745}, doi = {10.1007/978-1-4939-7672-0_28}, pages = {339 -- 358}, year = {2018}, abstract = {Leaf senescence is an essential developmental process that involves diverse metabolic changes associated with degradation of macromolecules allowing nutrient recycling and remobilization. In contrast to the significant progress in transcriptomic analysis of leaf senescence, metabolomics analyses have been relatively limited. A broad overview of metabolic changes during leaf senescence including the interactions between various metabolic pathways is required to gain a better understanding of the leaf senescence allowing to link transcriptomics with metabolomics and physiology. In this chapter, we describe how to obtain comprehensive metabolite profiles and how to dissect metabolic shifts during leaf senescence in the model plant Arabidopsis thaliana. Unlike nucleic acid analysis for transcriptomics, a comprehensive metabolite profile can only be achieved by combining a suite of analytic tools. Here, information is provided for measurements of the contents of chlorophyll, soluble proteins, and starch by spectrophotometric methods, ions by ion chromatography, thiols and amino acids by HPLC, primary metabolites by GC/TOF-MS, and secondary metabolites and lipophilic metabolites by LC/ESI-MS. These metabolite profiles provide a rich catalogue of metabolic changes during leaf senescence, which is a helpful database and blueprint to be correlated to future studies such as transcriptome and proteome analyses, forward and reverse genetic studies, or stress-induced senescence studies.}, language = {en} } @article{deWiljesReichStannat2018, author = {de Wiljes, Jana and Reich, Sebastian and Stannat, Wilhelm}, title = {Long-Time stability and accuracy of the ensemble Kalman-Bucy Filter for fully observed processes and small measurement noise}, series = {SIAM Journal on Applied Dynamical Systems}, volume = {17}, journal = {SIAM Journal on Applied Dynamical Systems}, number = {2}, publisher = {Society for Industrial and Applied Mathematics}, address = {Philadelphia}, issn = {1536-0040}, doi = {10.1137/17M1119056}, pages = {1152 -- 1181}, year = {2018}, abstract = {The ensemble Kalman filter has become a popular data assimilation technique in the geosciences. However, little is known theoretically about its long term stability and accuracy. In this paper, we investigate the behavior of an ensemble Kalman-Bucy filter applied to continuous-time filtering problems. We derive mean field limiting equations as the ensemble size goes to infinity as well as uniform-in-time accuracy and stability results for finite ensemble sizes. The later results require that the process is fully observed and that the measurement noise is small. We also demonstrate that our ensemble Kalman-Bucy filter is consistent with the classic Kalman-Bucy filter for linear systems and Gaussian processes. We finally verify our theoretical findings for the Lorenz-63 system.}, language = {en} } @article{ThienenClanceyCorazzaetal.2018, author = {Thienen, Julia von and Clancey, William J. and Corazza, Giovanni Emanuele and Meinel, Christoph}, title = {Theoretical foundations of design thinking creative thinking theories}, series = {Design Thinking Research: Making Distinctions: Collaboration versus Cooperation}, journal = {Design Thinking Research: Making Distinctions: Collaboration versus Cooperation}, publisher = {Springer}, address = {New York}, isbn = {978-3-319-60967-6}, doi = {10.1007/978-3-319-60967-6_2}, pages = {13 -- 40}, year = {2018}, abstract = {Design thinking is acknowledged as a thriving innovation practice plus something more, something in the line of a deep understanding of innovation processes. At the same time, quite how and why design thinking works-in scientific terms-appeared an open question at first. Over recent years, empirical research has achieved great progress in illuminating the principles that make design thinking successful. Lately, the community began to explore an additional approach. Rather than setting up novel studies, investigations into the history of design thinking hold the promise of adding systematically to our comprehension of basic principles. This chapter makes a start in revisiting design thinking history with the aim of explicating scientific understandings that inform design thinking practices today. It offers a summary of creative thinking theories that were brought to Stanford Engineering in the 1950s by John E. Arnold.}, language = {en} } @article{SchmidtGertenHintzeetal.2018, author = {Schmidt, Silke Regina and Gerten, Dieter and Hintze, Thomas and Lischeid, Gunnar and Livingstone, David M. and Adrian, Rita}, title = {Temporal and spatial scales of water temperature variability as an indicator for mixing in a polymictic lake}, series = {Inland waters : journal of the International Society of Limnology}, volume = {8}, journal = {Inland waters : journal of the International Society of Limnology}, number = {1}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {2044-2041}, doi = {10.1080/20442041.2018.1429067}, pages = {82 -- 95}, year = {2018}, abstract = {We applied coarse spectral analysis to more than 2 decades of daily near-surface water temperature (WT) measurements from Muggelsee, a shallow polymictic lake in Germany, to systematically characterize patterns in WT variability from daily to yearly temporal scales. Comparison of WT with local air temperature indicates that the WT variability patterns are likely attributable to both meteorological forcing and internal lake dynamics. We identified seasonal patterns of WT variability and showed that WT variability increases with increasing Schmidt stability, decreasing Lake number and decreasing ice cover duration, and is higher near the shore than in open water. We introduced the slope of WT spectra as an indicator for the degree of lake mixing to help explain the identified temporal and spatial scales of WT variability. The explanatory power of this indicator in other lakes with different mixing regimes remains to be established.}, language = {en} } @article{KruegerGengeSchulzKratzetal.2018, author = {Kr{\"u}ger-Genge, Anne and Schulz, Christian and Kratz, Karl and Lendlein, Andreas and Jung, Friedrich}, title = {Comparison of two substrate materials used as negative control in endothelialization studies}, series = {Clinical hemorheology and microcirculation : blood flow and vessels}, volume = {69}, journal = {Clinical hemorheology and microcirculation : blood flow and vessels}, number = {3}, publisher = {IOS Press}, address = {Amsterdam}, issn = {1386-0291}, doi = {10.3233/CH-189904}, pages = {437 -- 445}, year = {2018}, abstract = {The endothelialization of synthetic surfaces applied as cardiovascular implant materials is an important issue to ensure the anti-thrombotic quality of a biomaterial. However, the rapid and constant development of a functionallycon-fluent endothelial cell monolayer is challenging. In order to investigate the compatibility of potential implant materials with endothelial cells several in vitro studies are performed. Here, glass and tissue culture plates (TCP) are often used as reference materials for in vitro pre-testing. However, a direct comparison of both substrates is lacking. Therefore, a comparison of study results is difficult, since results are often related to various reference materials. In this study, the endothelialization of glass and TCP was investigated in terms of adherence, morphology, integrity, viability and function using human umbilical vein endothelial cells (HUVEC). On both substrates an almost functionally confluent HUVEC monolayer was developed after nine days of cell seeding with clearly visible cell rims, decreased stress fiber formation and a pronounced marginal filament band. The viability of HUVEC was comparable for both substrates nine days after cell seeding with only a few dead cells. According to that, the cell membrane integrity as well as the metabolic activity showed no differences between TCP and glass. However, a significant difference was observed for the secretion of IL-6 and IL-8. The concentration of both cytokines, which are associated with migratory activity, was increased in the supernatant of HUVEC seeded on TCP. This result matches well with the slightly increased number of adherent HUVEC on TCP. In conclusion, these findings indicate that both reference materials are almost comparable and can be used equivalently as control materials in in vitro endothelialization studies.}, language = {en} } @article{KruegerGengeBrauneWalteretal.2018, author = {Kr{\"u}ger-Genge, A. and Braune, S. and Walter, M. and Krengel, M. and Kratz, K. and K{\"u}pper, J. H. and Lendlein, Andreas and Jung, Friedrich}, title = {Influence of different surface treatments of poly(n-butyl acrylate) networks on fibroblasts adhesion, morphology and viability}, series = {Clinical hemorheology and microcirculation : blood flow and vessels}, volume = {69}, journal = {Clinical hemorheology and microcirculation : blood flow and vessels}, number = {1-2}, publisher = {IOS Press}, address = {Amsterdam}, issn = {1386-0291}, doi = {10.3233/CH-189130}, pages = {305 -- 316}, year = {2018}, abstract = {BACKGROUND: Physical and chemical characteristics of implant materials determine the fate of long-term cardiovascular devices. However, there is still a lack of fundamental understanding of the molecular mechanisms occurring in the material-tissue interphase. In a previous study, soft covalently crosslinked poly(n-butyl acrylate) networks (cPnBA) were introduced as sterilizable, non-toxic and immuno-compatible biomaterials with mechanical properties adjustable to blood vessels. Here we study the influence of different surface treatments in particular oxygen plasma modification and fibrinogen deposition as well as a combinatorial approach on the adhesion and viability of fibroblasts. RESULTS: Compared to non-treated cPnBAs the advancing water-contact angles were found to be reduced after all surface modifications (p<0.05, each), while lowest values were observed after the combined surface treatment (OPT+FIB). The latter differed significantly from the single OPT and FIB. The number of adherent fibroblasts and their adherence behavior differed on both pristine cPnBA networks. The fibroblast density on cPnBA04 was 743 +/- 434 cells. mm(-2), was about 6.5 times higher than on cPnBA73 with 115 +/- 73 cells. mm(-2). On cPnBA04 about 20\% of the cells were visible as very small, round and buckled cells while all other cells were in a migrating status. On cPnBA73, nearly 50\% of fibroblasts were visible as very small, round and buckled cells. The surface functionalization either using oxygen plasma treatment or fibrinogen coating led to a significant increase of adherent fibroblasts, particularly the combination of both techniques, for both cPnBA networks. It is noteworthy to mention that the fibrinogen coating overruled the characteristics of the pristine surfaces; here, the fibroblast densities after seeding were identical for both cPnBAnetworks. Thus, the binding rather depended on the fibrinogen coating than on the substrate characteristics anymore. While the integrity of the fibroblasts membrane was comparable for both polymers, the MTS tests showed a decreased metabolic activity of the fibroblasts on cPnBA. CONCLUSION: The applied surface treatments of cPnBA successfully improved the adhesion of viable fibroblasts. Under resting conditions as well as after shearing the highest fibroblast densities were found on surfaces with combined post-treatment.}, language = {en} } @article{KumarHeuchelKratzetal.2018, author = {Kumar, Reddi K. and Heuchel, Matthias and Kratz, Karl and Lendlein, Andreas and Jankowski, Joachim and Tetali, Sarada D.}, title = {Effects of extracts prepared from modified porous poly(ether imide) microparticulate absorbers on cytotoxicity, macrophage differentiation and proinflammatory behavior of human monocytic (THP-1) cells}, series = {Clinical hemorheology and microcirculation : blood flow and vessels}, volume = {69}, journal = {Clinical hemorheology and microcirculation : blood flow and vessels}, number = {1-2}, publisher = {IOS Press}, address = {Amsterdam}, issn = {1386-0291}, doi = {10.3233/CH-189112}, pages = {175 -- 185}, year = {2018}, abstract = {Remaining uremic toxins in the blood of chronic renal failure patients represent one central challenge in hemodialysis therapies. Highly porous poly(ether imide) (PEI) microparticles have been recently introduced as candidate absorber materials, which show a high absorption capacity for uremic toxins and allow hydrophilic surface modification suitable for minimization of serum protein absorption. In this work, the effects of extracts prepared from PEI microparticles modified by nucleophilic reaction with low molecular weight polyethylene imine (Pei) or potassium hydroxide (KOH), on human monocytic (THP-1) cells are studied. The obtained results suggested that the extracts of Pei and KOH modified PEI absorbers have no negative effect on THP-1 cell viability and do not initiate the critical differentiation towards macrophages. The extracts did not enhance transcript or protein levels of investigated proinflammatory markers in THP-1 cells, namely, TNF alpha, MCP1, IL6 and IL8. Based on these findings such modified PEI microparticles should be qualified for further pre-clinical evaluation i.e. in an in vivo animal experiment.}, language = {en} } @article{BourneCushingLiuetal.2018, author = {Bourne, D. P. and Cushing, D. and Liu, S. and M{\"u}nch, Florentin and Peyerimhoff, Norbert}, title = {Ollivier-Ricci idleness functions of graphs}, series = {SIAM Journal on Discrete Mathematics}, volume = {32}, journal = {SIAM Journal on Discrete Mathematics}, number = {2}, publisher = {Society for Industrial and Applied Mathematics}, address = {Philadelphia}, issn = {0895-4801}, doi = {10.1137/17M1134469}, pages = {1408 -- 1424}, year = {2018}, abstract = {We study the Ollivier-Ricci curvature of graphs as a function of the chosen idleness. We show that this idleness function is concave and piecewise linear with at most three linear parts, and at most two linear parts in the case of a regular graph. We then apply our result to show that the idleness function of the Cartesian product of two regular graphs is completely determined by the idleness functions of the factors.}, language = {en} } @article{Soto2018, author = {Soto, Paulina}, title = {Una reeducaci{\´o}n cr{\´i}tica: emergencia de revistas literarias digitales chilenas en el transcurso de la primera d{\´e}cada del siglo XXI}, series = {Estudios Avanzados}, journal = {Estudios Avanzados}, number = {28}, publisher = {Universidad de Santiago de Chile (USACH)}, address = {Santiago}, issn = {0718-5022}, pages = {121 -- 137}, year = {2018}, abstract = {Para inicios del siglo XXI se instalan nuevos medios de cr{\´i}tica literaria a trav{\´e}s de soportes digitales. Estas publicaciones tensionan un campo letrado chileno que enfrenta cuestionamientos. Gestionadas mayoritariamente por creadores precedentes de la generaci{\´o}n del 90, producen reaproximaciones a la cultura letrada. El objetivo es desafiar din{\´a}micas de interacci{\´o}n lectora heredadas vinculadas a las luces patria, desarrollistas, de tipo linear y ciegas a la heterogeneidad cultural vivida en la {\´e}poca. El proceso comprende, de tal modo, una reeducaci{\´o}n cr{\´i}tica centrada en ensayar po{\´e}ticas de productividad anal{\´i}tico-literarias heter{\´o}clitas. Se trata de una interacci{\´o}n lectora diversa, sujeta a ret{\´o}ricas {\´i}ntimas de apreciaci{\´o}n est{\´e}tica, que ponen en cuesti{\´o}n las nociones tradicionales mayoritariamente instructiva de la cultura chilena.}, language = {es} } @article{MartinezChicharroTorrejonOskinovaetal.2018, author = {Martinez-Chicharro, M. and Torrejon, J. M. and Oskinova, Lida and Furst, F. and Postnov, K. and Rodes-Roca, J. J. and Hainich, Rainer and Bodaghee, A.}, title = {Evidence of Compton cooling during an X-ray flare supports a neutron star nature of the compact object in 4U1700-37}, series = {Monthly notices of the Royal Astronomical Society}, volume = {473}, journal = {Monthly notices of the Royal Astronomical Society}, number = {1}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0035-8711}, doi = {10.1093/mnrasl/slx165}, pages = {L74 -- L78}, year = {2018}, abstract = {Based on new Chandra X-ray telescope data, we present empirical evidence of plasma Compton cooling during a flare in the non-pulsating massive X-ray binary 4U1700-37. This behaviour might be explained by quasi-spherical accretion on to a slowly rotating magnetized neutron star (NS). In quiescence, the NS in 4U1700-37 is surrounded by a hot radiatively cooling shell. Its presence is supported by the detection of mHz quasi-periodic oscillations likely produced by its convection cells. The high plasma temperature and the relatively low X-ray luminosity observed during the quiescence, point to a small emitting area similar to 1 km, compatible with a hotspot on an NS surface. The sudden transition from a radiative to a significantly more efficient Compton cooling regime triggers an episode of enhanced accretion resulting in a flare. During the flare, the plasma temperature drops quickly. The predicted luminosity for such transitions, similar to 3 x 10(35) erg s(-1), is very close to the luminosity of 4U1700-37 during quiescence. The transition may be caused by the accretion of a clump in the stellar wind of the donor star. Thus, a magnetized NS nature of the compact object is strongly favoured.}, language = {en} } @article{VerissimoHeyerJacobetal.2018, author = {Verissimo, Joao Marques and Heyer, Vera and Jacob, Gunnar and Clahsen, Harald}, title = {Selective effects of age of acquisition on morphological priming}, series = {Language acquisition : a journal of developmental linguistics}, volume = {25}, journal = {Language acquisition : a journal of developmental linguistics}, number = {3}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {1048-9223}, doi = {10.1080/10489223.2017.1346104}, pages = {315 -- 326}, year = {2018}, abstract = {Is there an ideal time window for language acquisition after which nativelike representation and processing are unattainable? Although this question has been heavily debated, no consensus has been reached. Here, we present evidence for a sensitive period in language development and show that it is specific to grammar. We conducted a masked priming task with a group of Turkish-German bilinguals and examined age of acquisition (AoA) effects on the processing of complex words. We compared a subtle but meaningful linguistic contrast, that between grammatical inflection and lexical-based derivation. The results showed a highly selective AoA effect on inflectional (but not derivational) priming. In addition, the effect displayed a discontinuity indicative of a sensitive period: Priming from inflected forms was nativelike when acquisition started before the age of 5 but declined with increasing AoA. We conclude that the acquisition of morphological rules expressing morphosyntactic properties is constrained by maturational factors.}, language = {en} } @article{Waller2018, author = {Waller, Nicole}, title = {Connecting Atlantic and Pacific: Theorizing the Arctic}, series = {Atlantic studies : literary, cultural and historical perspectives}, volume = {15}, journal = {Atlantic studies : literary, cultural and historical perspectives}, number = {2}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {1478-8810}, doi = {10.1080/14788810.2017.1387467}, pages = {256 -- 278}, year = {2018}, abstract = {This essay sets out to theorize the "new" Arctic Ocean as a pivot from which our standard map of the world is currently being reconceptualized. Drawing on theories from the fields of Atlantic and Pacific studies, I argue that the changing Arctic, characterized by melting ice and increased accessibility, must be understood both as a space of transit that connects Atlantic and Pacific worlds in unprecedented ways, and as an oceanic world and contact zone in its own right. I examine both functions of the Arctic via a reading of the dispute over the Northwest Passage (which emphasizes the Arctic as a space of transit) and the contemporary assessment of new models of sovereignty in the Arctic region (which concentrates on the circumpolar Arctic as an oceanic world). However, both of these debates frequently exclude indigenous positions on the Arctic. By reading Canadian Inuit theories on the Arctic alongside the more prominent debates, I argue for a decolonizing reading of the Arctic inspired by Inuit articulations of the "Inuit Sea." In such a reading, Inuit conceptions provide crucial interventions into theorizing the Arctic. They also, in turn, contribute to discussions on indigeneity, sovereignty, and archipelagic theory in Atlantic and Pacific studies.}, language = {en} } @article{WangLiZhangetal.2018, author = {Wang, Guang and Li, Pei-zhi and Zhang, Shi-yao and Zhong, Shan and Chu, Chang and Zeng, Shufei and Yan, Yu and Cheng, Xin and Chuai, Manli and Hocher, Berthold and Yang, Xuesong}, title = {Lipopolysaccharides (LPS) Induced Angiogenesis During Chicken Embryogenesis is Abolished by Combined ETA/ETB Receptor Blockade}, series = {Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology}, volume = {48}, journal = {Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology}, number = {5}, publisher = {Karger}, address = {Basel}, issn = {1015-8987}, doi = {10.1159/000492547}, pages = {2084 -- 2090}, year = {2018}, abstract = {Background/Aims: Angiogenesis plays a key role during embryonic development. The vascular endothelin (ET) system is involved in the regulation of angiogenesis. Lipopolysaccharides (LPS) could induce angiogenesis. The effects of ET blockers on baseline and LPS-stimulated angiogenesis during embryonic development remain unknown so far. Methods: The blood vessel density (BVD) of chorioallantoic membranes (CAMs), which were treated with saline (control), LPS, and/or BQ123 and the ETB blocker BQ788, were quantified and analyzed using an IPP 6.0 image analysis program. Moreover, the expressions of ET-1, ET-2, ET3, ET receptor A (ETRA), ET receptor B (ETRB) and VEGFR2 mRNA during embryogenesis were analyzed by semi-quantitative RT-PCR. Results: All components of the ET system are detectable during chicken embryogenesis. LPS increased angiogenesis substantially. This process was completely blocked by the treatment of a combination of the ETA receptor blockers-BQ123 and the ETB receptor blocker BQ788. This effect was accompanied by a decrease in ETRA, ETRB, and VEGFR2 gene expression. However, the baseline angiogenesis was not affected by combined ETA/ETB receptor blockade. Conclusion: During chicken embryogenesis, the LPS-stimulated angiogenesis, but not baseline angiogenesis, is sensitive to combined ETA/ETB receptor blockade.}, language = {en} }