@article{EbelBald2020, author = {Ebel, Kenny and Bald, Ilko}, title = {Length and Energy Dependence of Low-Energy Electron-Induced Strand Breaks in Poly(A) DNA}, series = {International Journal of Molecular Sciences}, volume = {21}, journal = {International Journal of Molecular Sciences}, number = {1}, publisher = {Molecular Diversity Preservation International}, address = {Basel}, issn = {1422-0067}, doi = {10.3390/ijms21010111}, pages = {11}, year = {2020}, abstract = {The DNA in living cells can be effectively damaged by high-energy radiation, which can lead to cell death. Through the ionization of water molecules, highly reactive secondary species such as low-energy electrons (LEEs) with the most probable energy around 10 eV are generated, which are able to induce DNA strand breaks via dissociative electron attachment. Absolute DNA strand break cross sections of specific DNA sequences can be efficiently determined using DNA origami nanostructures as platforms exposing the target sequences towards LEEs. In this paper, we systematically study the effect of the oligonucleotide length on the strand break cross section at various irradiation energies. The present work focuses on poly-adenine sequences (d(A₄), d(A₈), d(A₁₂), d(A₁₆), and d(A₂₀)) irradiated with 5.0, 7.0, 8.4, and 10 eV electrons. Independent of the DNA length, the strand break cross section shows a maximum around 7.0 eV electron energy for all investigated oligonucleotides confirming that strand breakage occurs through the initial formation of negative ion resonances. When going from d(A₄) to d(A₁₆), the strand break cross section increases with oligonucleotide length, but only at 7.0 and 8.4 eV, i.e., close to the maximum of the negative ion resonance, the increase in the strand break cross section with the length is similar to the increase of an estimated geometrical cross section. For d(A₂₀), a markedly lower DNA strand break cross section is observed for all electron energies, which is tentatively ascribed to a conformational change of the dA₂₀ sequence. The results indicate that, although there is a general length dependence of strand break cross sections, individual nucleotides do not contribute independently of the absolute strand break cross section of the whole DNA strand. The absolute quantification of sequence specific strand breaks will help develop a more accurate molecular level understanding of radiation induced DNA damage, which can then be used for optimized risk estimates in cancer radiation therapy.}, language = {en} } @article{Hassler2020, author = {Haßler, Gerda}, title = {Sprache als Epiph{\"a}nomen in der Geschichte der Sprachwissenschaft}, series = {Per la storia della linguistica. Saggi in onore di Giorgio Graffi per il suo 70esimo compleanno = Blityri. Studi di storia delle idee sui segni e le lingue VIII, 1-2 (2019)}, volume = {VIII /2019}, journal = {Per la storia della linguistica. Saggi in onore di Giorgio Graffi per il suo 70esimo compleanno = Blityri. Studi di storia delle idee sui segni e le lingue VIII, 1-2 (2019)}, number = {1-2}, publisher = {Edizioni ETS}, address = {Pisa}, isbn = {88-467-5675-4}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-441580}, pages = {191 -- 206}, year = {2020}, abstract = {The notion of 'epiphenomenon' is usually used to exclude certain aspects of a scientific object because they are considered to be deduced from others. In linguistics, restrictions of the research object were made, invoking the notion of 'epiphenomenon', which was partially done with a polemical attitude, and was always responded to polemically. The best-known definition of languages as an epiphenomenon is that proposed by Chomsky, who declared that the specific realisations of language do not warrant scientific attention, but there were early relegations of properties of individual languages to the domain of an epiphenomenon of grammar, to the domain of an art and not a science. These relegations from a certain point of abstraction did advance theories of language, even though they took a point of abstraction that did not correspond to the complexity of language.}, language = {de} } @article{Philipowski2020, author = {Philipowski, Katharina}, title = {„Wer sich selbst erniedrigt, will erh{\"o}ht werden."}, series = {Zeitschrift f{\"u}r deutsches Altertum und deutsche Literatur (ZfdA), Beihefte = Rudolf von Ems : Beitr{\"a}ge zu Autor, Werk und {\"U}berlieferung / K{\"o}ssinger, Norbert; Manuwald, Henrike; M{\"u}ller, Stephan (Hrsg.)}, journal = {Zeitschrift f{\"u}r deutsches Altertum und deutsche Literatur (ZfdA), Beihefte = Rudolf von Ems : Beitr{\"a}ge zu Autor, Werk und {\"U}berlieferung / K{\"o}ssinger, Norbert; Manuwald, Henrike; M{\"u}ller, Stephan (Hrsg.)}, number = {29}, editor = {Krotz, Elke and K{\"o}ssinger, Norbert and Manuwald, Henrike and M{\"u}ller, Stephan}, publisher = {Hirtzel}, address = {Stuttgart}, isbn = {978-3-7776-2679-6}, pages = {63 -- 88}, year = {2020}, language = {de} } @article{Ludwig2020, author = {Ludwig, Joachim}, title = {Geht das unter die Haut?}, series = {Erwachsenenbildung und Lernen in Zeiten von Globalisierung, Transformation und Entgrenzung}, journal = {Erwachsenenbildung und Lernen in Zeiten von Globalisierung, Transformation und Entgrenzung}, publisher = {Budrich}, address = {Opladen}, isbn = {978-3-8474-2345-4}, pages = {327 -- 340}, year = {2020}, language = {de} } @article{Wallraf2020, author = {Wallraf, Wolfram}, title = {Strategische Autonomie Europas}, series = {WeltTrends das außenpolitische Journal}, volume = {28}, journal = {WeltTrends das außenpolitische Journal}, number = {159}, publisher = {WeltTrends}, address = {Potsdam}, issn = {0944-8101}, pages = {50 -- 53}, year = {2020}, language = {de} } @article{Kleinwaechter2020, author = {Kleinw{\"a}chter, Lutz}, title = {Militante Verantwortungslosigkeit}, series = {WeltTrends das außenpolitische Journal}, volume = {28}, journal = {WeltTrends das außenpolitische Journal}, number = {159}, publisher = {WeltTrends}, address = {Potsdam}, isbn = {978-3-947802-32-6}, pages = {68 -- 69}, year = {2020}, language = {de} }