@article{KalkuhlSteckelEdenhofer2020, author = {Kalkuhl, Matthias and Steckel, Jan Christoph and Edenhofer, Ottmar}, title = {All or nothing}, series = {Journal of environmental economics and management}, volume = {100}, journal = {Journal of environmental economics and management}, publisher = {Elsevier}, address = {San Diego}, issn = {0095-0696}, doi = {10.1016/j.jeem.2019.01.012}, pages = {21}, year = {2020}, abstract = {This paper develops a new perspective on stranded assets in climate policy using a partial equilibrium model of the energy sector. Political-economy related aspects are considered in the government's objective function. Lobbying power of firms or fiscal considerations by the government lead to time inconsistency: The government will deviate from a previously announced carbon tax which creates stranded assets. Under rational expectations, we show that a time-consistent policy outcome exists with either a zero carbon tax or a prohibitive carbon tax that leads to zero fossil investments - an "all-or-nothing" policy. Although stranded assets are crucial to such a bipolar outcome, they disappear again under time-consistent policy. Which of the two outcomes (all or nothing) prevails depends on the lobbying power of owners of fixed factors (land and fossil resources) but not on fiscal revenue considerations or on the lobbying power of renewable or fossil energy firms.}, language = {en} } @article{OlasFichtnerApelt2020, author = {Olas, Justyna Jadwiga and Fichtner, Franziska and Apelt, Federico}, title = {All roads lead to growth}, series = {Journal of experimental botany}, volume = {71}, journal = {Journal of experimental botany}, number = {1}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0022-0957}, doi = {10.1093/jxb/erz406}, pages = {11 -- 21}, year = {2020}, abstract = {Plant growth is a highly complex biological process that involves innumerable interconnected biochemical and signalling pathways. Many different techniques have been developed to measure growth, unravel the various processes that contribute to plant growth, and understand how a complex interaction between genotype and environment determines the growth phenotype. Despite this complexity, the term 'growth' is often simplified by researchers; depending on the method used for quantification, growth is viewed as an increase in plant or organ size, a change in cell architecture, or an increase in structural biomass. In this review, we summarise the cellular and molecular mechanisms underlying plant growth, highlight state-of-the-art imaging and non-imaging-based techniques to quantitatively measure growth, including a discussion of their advantages and drawbacks, and suggest a terminology for growth rates depending on the type of technique used.}, language = {en} } @article{SchubarthMauermeisterSchulzeReicheltetal.2020, author = {Schubarth, Wilfried and Mauermeister, Sylvi and Schulze-Reichelt, Friederike and Erdmann, Melinda}, title = {Alles auf (Studien-)Anfang? Faktoren f{\"u}r den Studienerfolg in der Eingangsphase und zur Studienmitte}, series = {Potsdamer Beitr{\"a}ge zur Hochschulforschung}, journal = {Potsdamer Beitr{\"a}ge zur Hochschulforschung}, number = {6}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-498-2}, issn = {2192-1075}, doi = {10.25932/publishup-49262}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-492623}, pages = {27 -- 54}, year = {2020}, abstract = {Die hohen Abbruchquoten, insbesondere in der Studieneingangsphase, haben die Hochschulen in Deutschland veranlasst, eine Vielzahl von Maßnahmen zu ergreifen, {\"u}ber deren Wirkungen bisher allerdings wenig bekannt ist. Im vorliegenden Beitrag werden Befunde eines Forschungsprojekts speziell zur Studieneingangsphase sowie erg{\"a}nzend zur Studienmitte vorgestellt, dessen Ziel es war, Bedingungen eines erfolgreichen Studieneinstiegs zu identifizieren und Empfehlungen f{\"u}r eine Optimierung des Studieneingangs abzuleiten. Das Forschungsdesign umfasste neben qualitativen Studien vor allem eine quantitative L{\"a}ngsschnittbefragung an f{\"u}nf Universit{\"a}ten (Potsdam, Mainz, Magdeburg, Kiel und Greifswald). Im Ergebnis der Analysen konnte die forschungsleitende Hypothese, dass Maßnahmen zum Studieneingang vor allem dann zur Erh{\"o}hung des Studienerfolgs einen Beitrag leisten, wenn sie zur akademischen und sozialen Integration in die Hochschule beitragen, best{\"a}tigt werden. Bedeutsam f{\"u}r den Studienerfolg sind demnach insbesondere solche Faktoren wie die Identifikation mit dem Studienfach, die Selbstwirksamkeit, die berufliche bzw. erfolgsorientierte Lernmotivation und die akademische Integration. Daneben konnte ein positiver Einfluss des sozialen Klimas sowie des Forschungs- und Praxisbezugs auf die Studienzufriedenheit nachgewiesen werden. Weiterf{\"u}hrende Analysen zur Studienmitte verdeutlichen zudem, dass f{\"u}r die beiden Studienphasen (Eingang und Studienmitte) gleiche Faktoren bei zum Teil unterschiedlicher Gewichtung eine Rolle spielen. So ist die soziale Integration ein wesentlicher Pr{\"a}diktor in beiden Phasen - in der Eingangsphase eher in die Studierendenschaft und im weiteren Studienverlauf (Studienmitte) eher in die akademische Gemeinschaft (in Form von Lehrenden). Insofern muss die Eingangsfrage wie folgt beantwortet werden: Ja, alles auf Anfang, aber dann mit den Bem{\"u}hungen, soziale und akademische Integration aller Studierenden voll und ganz zu gew{\"a}hrleisten. Zudem machen die Befunde auf die bisher offenbar untersch{\"a}tzte Rolle von Verwertungsmotiven aufmerksam.}, language = {de} } @article{PoensgenSteinitz2020, author = {Poensgen, Daniel and Steinitz, Benjamin}, title = {Alltagspr{\"a}gende Erfahrungen sichtbar machen}, series = {Das neue Unbehagen - Antisemitismus in Deutschland heute}, journal = {Das neue Unbehagen - Antisemitismus in Deutschland heute}, edition = {2. unver{\"a}nderte}, publisher = {Olms}, address = {Hildesheim}, isbn = {978-3-7582-0358-9}, pages = {173 -- 197}, year = {2020}, language = {de} } @article{vonKalckreuth2020, author = {von Kalckreuth, Moritz}, title = {Allt{\"a}gliche Lebenswirklichkeit und ontologische Theorie}, series = {Deutsche Zeitschrift f{\"u}r Philosophie : Zweimonatsschrift der internationalen philosophischen Forschung}, volume = {68}, journal = {Deutsche Zeitschrift f{\"u}r Philosophie : Zweimonatsschrift der internationalen philosophischen Forschung}, number = {2}, publisher = {De Gruyter}, address = {Berlin}, issn = {0012-1045}, doi = {10.1515/dzph-2020-0017}, pages = {275 -- 287}, year = {2020}, abstract = {The aim of this paper is to discuss the relation between our experience in everyday life and ontological reflection. While many accounts in contemporary ontology still defend the idea that the world consists only of material objects, some new views on everyday metaphysics or social ontology which try to articulate the specific properties of the objects used and found in ordinary life have been established during the last years. In the critical ontology of Nicolai Hartmann, the social and cultural dimension of our life is situated in the sphere of spiritual being [Geistiges Sein]. By investigating the methodical relation of phenomenology and critical ontology as well as specific entities (objective spirit, cultural objects), it is established that Hartmann offers a wide and methodologically reflected view which could be able to satisfy the practical significance of these entities.}, language = {de} } @article{PelisoliVosGeieretal.2020, author = {Pelisoli, Ingrid and Vos, Joris and Geier, Stephan and Schaffenroth, Veronika and Baran, Andrzej S.}, title = {Alone but not lonely}, series = {Astronomy and astrophysics : an international weekly journal}, volume = {642}, journal = {Astronomy and astrophysics : an international weekly journal}, publisher = {EDP Sciences}, address = {Les Ulis}, issn = {0004-6361}, doi = {10.1051/0004-6361/202038473}, pages = {14}, year = {2020}, abstract = {Context. Hot subdwarfs are core-helium burning stars that show lower masses and higher temperatures than canonical horizontal branch stars. They are believed to be formed when a red giant suffers an extreme mass-loss episode. Binary interaction is suggested to be the main formation channel, but the high fraction of apparently single hot subdwarfs (up to 30\%) has prompted single star formation scenarios to be proposed.Aims. We investigate the possibility that hot subdwarfs could form without interaction by studying wide binary systems. If single formation scenarios were possible, there should be hot subdwarfs in wide binaries that have undergone no interaction.Methods. Angular momentum accretion during interaction is predicted to cause the hot subdwarf companion to spin up to the critical velocity. The effect of this should still be observable given the timescales of the hot subdwarf phase. To study the rotation rates of companions, we have analysed light curves from the Transiting Exoplanet Survey Satellite for all known hot subdwarfs showing composite spectral energy distributions indicating the presence of a main sequence wide binary companion. If formation without interaction were possible, that would also imply the existence of hot subdwarfs in very wide binaries that are not predicted to interact. To identify such systems, we have searched for common proper motion companions with projected orbital distances of up to 0.1 pc to all known spectroscopically confirmed hot subdwarfs using Gaia DR2 astrometry.Results. We find that the companions in composite hot subdwarfs show short rotation periods when compared to field main sequence stars. They display a triangular-shaped distribution with a peak around 2.5 days, similar to what is observed for young open clusters. We also report a shortage of hot subdwarfs with candidate common proper motion companions. We identify only 16 candidates after probing 2938 hot subdwarfs with good astrometry. Out of those, at least six seem to be hierarchical triple systems, in which the hot subdwarf is part of an inner binary.Conclusions. The observed distribution of rotation rates for the companions in known wide hot subdwarf binaries provides evidence of previous interaction causing spin-up. Additionally, there is a shortage of hot subdwarfs in common proper motion pairs, considering the frequency of such systems among progenitors. These results suggest that binary interaction is always required for the formation of hot subdwarfs.}, language = {en} } @article{WochatzEngelMuelleretal.2020, author = {Wochatz, Monique and Engel, Tilman and M{\"u}ller, Steffen and Mayer, Frank}, title = {Alterations in scapular kinematics and scapular muscle activity after fatiguing shoulder flexion and extension movements}, series = {Medicine and science in sports and exercise : MSSE}, volume = {52}, journal = {Medicine and science in sports and exercise : MSSE}, number = {17}, publisher = {Lippincott Williams \& Wilkins}, address = {Philadelphia}, issn = {0195-9131}, doi = {10.1249/01.mss.0000676540.02017.2c}, pages = {274 -- 274}, year = {2020}, abstract = {Repetitive overhead motions in combination with heavy loading were identified as risk factors for the development of shoulder pain. However, the underlying mechanism is not fully understood. Altered scapular kinematics as a result of muscle fatigue is suspected to be a contributor. PURPOSE: To determine scapular kinematics and scapular muscle activity at the beginning and end of constant shoulder flexion and extension loading in asymptomatic individuals. METHODS: Eleven asymptomatic adults (28±4yrs; 1.74±0.13m; 74±16kg) underwent maximum isokinetic loading of shoulder flexion (FLX) and extension (EXT) in the sagittal plane (ROM: 20- 180°; concentric mode; 180°/s) until individual peak torque was reduced by 50\%. Simultaneously 3D scapular kinematics were assessed with a motion capture system and scapular muscle activity with a 3-lead sEMG of upper and lower trapezius (UT, LT) and serratus anterior (SA). Scapular position angles were calculated for every 20° increment between 20-120° humerothoracic positions. Muscle activity was quantified by amplitudes (RMS) of the total ROM. Descriptive analyses (mean±SD) of kinematics and muscle activity at begin (taskB) and end (taskE) of the loading task was followed by ANOVA and paired t-tests. RESULTS: At taskB activity ranged from 589±343mV to 605±250mV during FLX and from 105±41mV to 164±73mV during EXT across muscles. At taskE activity ranged from 594±304mV to 875±276mV during FLX and from 97±33mV to 147±57mV during EXT. Differences with increased muscle activity were seen for LT and UT during FLX (meandiff= 141±113mV for LT, p<0.01; 191±153mV for UT, p<0.01). Scapula position angles continuously increased in upward rotation, posterior tilt and external rotation during FLX and reversed during EXT both at taskB and taskE. At taskE scapula showed greater external rotation (meandiff= 3.6±3.7°, p<0.05) during FLX and decreased upward rotation (meandiff= 1.9±2.3°, p<0.05) and posterior tilt (meandiff= 1.0±2.1°, p<0.05) during EXT across humeral positions. CONCLUSIONS: Force reduction in consequence of fatiguing shoulder loading results in increased scapular muscle activity and minor alterations in scapula motion. Whether even small changes have a clinical impact by creating unfavorable subacromial conditions potentially initiating pain remains unclear.}, language = {en} } @article{SchedlbauerBlaueRailaetal.2020, author = {Schedlbauer, Carola and Blaue, Dominique and Raila, Jens and Vervuert, Ingrid}, title = {Alterations of serum vitamin E and vitamin A concentrations of ponies and horses during experimentally induced obesity}, series = {Journal of animal physiology and animal nutrition}, volume = {104}, journal = {Journal of animal physiology and animal nutrition}, number = {5}, publisher = {Wiley}, address = {Hoboken}, issn = {0931-2439}, doi = {10.1111/jpn.13385}, pages = {1501 -- 1508}, year = {2020}, abstract = {Vitamin A, vitamin E and retinol-binding protein 4 (RBP4) are a focus of current obesity research in humans. The impact of body weight (BW) gain on fat-soluble vitamins and its associated parameters in equines has not been previously reported. Ten Shetland ponies and 9 Warmblood horses, all adult geldings, non-obese and healthy, were fed an excessive energy diet for 20 months to induce BW gain. Serum alpha-tocopherol (vitamin E), retinol (vitamin A), retinol-binding protein 4 (RBP4) and retinol/RBP4 ratio were analysed before BW gain induction and at six timepoints during the BW gaining period. The mean (+/- SD) \% BW gain achieved during two years of excess energy intake was 29.9 +/- 19.4\% for ponies and 17 +/- 6.74\% for horses. Serum alpha-tocopherol increased significantly in ponies and horses during excess energy intake and circulating alpha-tocopherol levels correlated positively with alpha-tocopherol intake (r = .6; p < .001). Serum retinol concentrations showed variations during the study but without relation to intake. Serum RBP4 decreased at the end of the study. The retinol/RBP4 ratio increased with BW gain without differences between ponies and horses. In comparison with human research, the increase in the retinol/RBP4 ratio was unexpected and needs further elucidation.}, language = {en} } @article{Schumacher2020, author = {Schumacher, Reinhard}, title = {Altering the pattern of trade in the wealth of nations}, series = {Journal of the history of economic thought}, volume = {42}, journal = {Journal of the history of economic thought}, number = {1}, publisher = {Cambridge University Press}, address = {New York}, issn = {1053-8372}, doi = {10.1017/S1053837219000130}, pages = {19 -- 42}, year = {2020}, abstract = {There are three different interpretations of Adam Smith's trade theory in modern literature: first, the neoclassical theory of absolute advantage; second, an interpretation based on increasing returns; third, an interpretation of uneven development. These interpretations come to widely different conclusions, especially considering the development of the pattern of trade in Smith's theory. I discuss how these three interpretations emerged. They do not stem from a more detailed analysis of Smith's works itself but reflect changes within international trade theory. They all result from the fact that economists have imposed nineteenth- and twentieth-century modes of thoughts on Smith's theory, forcing his writings into later-developed theoretical frameworks. In contrast to classical economists in the nineteenth century, these subsequent interpretations misrepresent Smith's trade theory in order to portray him as a forerunner of later theories. The differing interpretations can thus be explained only against the backdrop of the development of international trade theory.}, language = {en} } @article{Weiss2020, author = {Weiss, Irene M.}, title = {Amarilis y la belleza de Zacinto}, series = {thersites 11: tessellae - Birthday Issue for Christine Walde}, volume = {2020}, journal = {thersites 11: tessellae - Birthday Issue for Christine Walde}, number = {11}, editor = {Amb{\"u}hl, Annemarie}, issn = {2364-7612}, doi = {10.34679/thersites.vol11.174}, pages = {1 -- 30}, year = {2020}, abstract = {Theocritus' id. 4 has been considered by some scholars as an example of rural mime; the fact that the poem, a unique case in the Corpus Theocriteum, does not contain any pastoral song or contest contributes to the impression of 'realism'. This lack could be an obstacle for the poetological approach to the bucolic genre in antiquity, which considers metapoetry as its main feature. Our reading of the idyll shows that this limitation is only apparent.}, language = {es} } @article{HessSchmidtSchlaad2020, author = {Hess, Andreas and Schmidt, Bernhard Volkmar Konrad Jakob and Schlaad, Helmut}, title = {Aminolysis induced functionalization of (RAFT) polymer-dithioester with thiols and disulfides}, series = {Polymer Chemistry}, volume = {11}, journal = {Polymer Chemistry}, number = {48}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1759-9954}, doi = {10.1039/d0py01365j}, pages = {7677 -- 7684}, year = {2020}, abstract = {A series of polystyrene- and poly(methyl methacrylate)-dithioesters was subjected to aminolysis under ambient atmospheric conditions, i.e., in the presence of oxygen. Polymer disulfide coupling by oxidation occurred within tens of minutes and the yield of disulfide-coupled polymer increased with decreasing polymer molar mass. Oxidation of thiolates is usually an unwanted side reaction, here it is employed to obtain exclusively polymeric mixed disulfides through in situ aminolysis/functionalization in the presence of a thiol. The in situ aminolysis/functionalization in the presence of a disulfide, Ellman's reagent or polymer disulfide, resulted in the exclusive formation of polymer-dithionitrobenzoic acid, which can be further reacted with a thiol to exchange the terminal functionality, or block copolymer with dynamic disulfide linker, respectively.}, language = {en} } @article{PochIstiqomahQuiricoetal.2020, author = {Poch, Olivier and Istiqomah, Istiqomah and Quirico, Eric and Beck, Pierre and Schmitt, Bernard and Theul{\´e}, Patrice and Faure, Alexandre and Hily-Blant, Pierre and Bonal, Lydie and Kappel, David}, title = {Ammonium salts are a reservoir of nitrogen on a cometary nucleus and possibly on some asteroids}, series = {Science}, volume = {367}, journal = {Science}, number = {6483}, publisher = {AAAS, American Association for the Advancement of Science}, address = {Washington, DC}, issn = {1095-9203}, doi = {10.1126/science.aaw7462}, pages = {1 -- 8}, year = {2020}, abstract = {The measured nitrogen-to-carbon ratio in comets is lower than for the Sun, a discrepancy which could be alleviated if there is an unknown reservoir of nitrogen in comets. The nucleus of comet 67P/Churyumov-Gerasimenko exhibits an unidentified broad spectral reflectance feature around 3.2 micrometers, which is ubiquitous across its surface. On the basis of laboratory experiments, we attribute this absorption band to ammonium salts mixed with dust on the surface. The depth of the band indicates that semivolatile ammonium salts are a substantial reservoir of nitrogen in the comet, potentially dominating over refractory organic matter and more volatile species. Similar absorption features appear in the spectra of some asteroids, implying a compositional link between asteroids, comets, and the parent interstellar cloud.}, language = {en} } @article{EccardLiesenjohannDammhahn2020, author = {Eccard, Jana and Liesenjohann, Thilo and Dammhahn, Melanie}, title = {Among-individual differences in foraging modulate resource exploitation under perceived predation risk}, series = {Oecologia}, volume = {194}, journal = {Oecologia}, number = {4}, publisher = {Springer}, address = {Berlin}, issn = {0029-8549}, doi = {10.1007/s00442-020-04773-y}, pages = {621 -- 634}, year = {2020}, abstract = {Foraging is risky and involves balancing the benefits of resource acquisition with costs of predation. Optimal foraging theory predicts where, when and how long to forage in a given spatiotemporal distribution of risks and resources. However, significant variation in foraging behaviour and resource exploitation remain unexplained. Using single foragers in artificial landscapes of perceived risks and resources with diminishing returns, we aimed to test whether foraging behaviour and resource exploitation are adjusted to risk level, vary with risk during different components of foraging, and (co)vary among individuals. We quantified foraging behaviour and resource exploitation for 21 common voles (Microtus arvalis). By manipulating ground cover, we created simple landscapes of two food patches varying in perceived risk during feeding in a patch and/or while travelling between patches. Foraging of individuals was variable and adjusted to risk level and type. High risk during feeding reduced feeding duration and food consumption more strongly than risk while travelling. Risk during travelling modified the risk effects of feeding for changes between patches and resulting evenness of resource exploitation. Across risk conditions individuals differed consistently in when and how long they exploited resources and exposed themselves to risk. These among-individual differences in foraging behaviour were associated with consistent patterns of resource exploitation. Thus, different strategies in foraging-under-risk ultimately lead to unequal payoffs and might affect lower trophic levels in food webs. Inter-individual differences in foraging behaviour, i.e. foraging personalities, are an integral part of foraging behaviour and need to be fully integrated into optimal foraging theory.}, language = {en} } @article{OthmanWollenberger2020, author = {Othman, Abdelmageed M. and Wollenberger, Ulla}, title = {Amperometric biosensor based on coupling aminated laccase to functionalized carbon nanotubes for phenolics detection}, series = {International journal of biological macromolecules}, volume = {153}, journal = {International journal of biological macromolecules}, publisher = {Elsevier}, address = {New York, NY [u.a.]}, issn = {0141-8130}, doi = {10.1016/j.ijbiomac.2020.03.049}, pages = {855 -- 864}, year = {2020}, abstract = {A biosensor for phenolic compounds based on a chemically modified laccase from Coriolus hirsula immobilized on functionalized screen-printed carbon electrodes (SPCEs) was achieved. Different enzyme modifications and immobilization strategies were analyzed. The electrochemical response of the immobilized laccase on SPCEs modified with carboxyl functionalized multi-walled carbon nanotubes (COOH-MWCNT) was the highest when laccase was aminated prior to the adsorption onto the working electrode. The developed lactase biosensor sensitivity toward different phenolic compounds was assessed to determine the biosensor response with several phenolic compounds. The highest response was obtained for ABTS with a saturation value of I-max = 27.94 mu A. The electrocatalytic efficiency (I-max/K-m(app)) was the highest for ABTS (5588 mu A mu M-1) followed by syringaldazine (3014 mu A.mu M-1). The sensors were considerably stable, whereby 99.5, 82 and 77\% of the catalytic response using catechol as substrate was retained after 4, 8 and 10 successive cycles of reuse respectively, with response time average of 5 s for 12 cycles. No loss of activity was observed after 20 days of storage.}, language = {en} } @article{Ulična2020, author = {Uličn{\´a}, Lenka}, title = {Amulets Found in Bohemian Genizot}, editor = {Denz, Rebekka and Rudolf, Gabi}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-470-8}, doi = {10.25932/publishup-47095}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-470952}, pages = {69 -- 80}, year = {2020}, language = {en} } @article{SeuffertWintzheimerOppmannetal.2020, author = {Seuffert, Marcel T. and Wintzheimer, Susanne and Oppmann, Maximilian and Granath, Tim and Prieschl, Johannes and Alrefai, Anas and Holdt, Hans-J{\"u}rgen and M{\"u}ller-Buschbaum, Klaus and Mandel, Karl}, title = {An all white magnet by combination of electronic properties of a white light emitting MOF with strong magnetic particle systems}, series = {Journal of materials chemistry : C, Materials for optical and electronic devices}, volume = {8}, journal = {Journal of materials chemistry : C, Materials for optical and electronic devices}, number = {45}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {2050-7526}, doi = {10.1039/d0tc03473h}, pages = {16010 -- 16017}, year = {2020}, abstract = {A multi-component particle system was developed that combines the properties of white color, white light emission and strong magnetism on the macroscopic and microscopic scale. The system is constituted by combination of an inorganic white core with either hard or soft magnetic properties and a white light emitting MOF. The key towards this achievement is the supraparticulate character constituted by a magnetic core, of either magnetite or alpha-Fe, surrounded by titania and silica nanoparticles of a certain size in a loose structural shell-arrangement as white components and finally the white light emitting metal-organic framework (MOF) EuTb@IFP-1 as building blocks of a core-shell structure. The supraparticles are created by forced assembly of the inorganic compounds and by combining spray-drying and postsynthetic modification by solvothermal chemistry. Thereby, the gap is bridged that homogenous compounds are either strongly magnetic, white in appearance or white light emitting. The composites presented herein inherit these properties intrinsically as electronic properties. The white characteristics are based on all optical properties that enable white: light reflection, refraction, and light emission. This work shifts the paradigm that strong magnetic materials are always expected to be intrinsically dark.}, language = {en} } @article{ObrehtWoermerBraueretal.2020, author = {Obreht, Igor and W{\"o}rmer, Lars and Brauer, Achim and Wendt, Jenny and Alfken, Susanne and De Vleeschouwer, David and Elvert, Marcus and Hinrichs, Kai-Uwe}, title = {An annually resolved record of Western European vegetation response to Younger Dryas cooling}, series = {Quaternary science reviews : the international multidisciplinary research and review journal}, volume = {231}, journal = {Quaternary science reviews : the international multidisciplinary research and review journal}, publisher = {Elsevier}, address = {Amsterdam [u.a.]}, issn = {0277-3791}, doi = {10.1016/j.quascirev.2020.106198}, pages = {15}, year = {2020}, abstract = {The regional patterns and timing of the Younger Dryas cooling in the North Atlantic realm were complex and are mechanistically incompletely understood. To enhance understanding of regional climate patterns, we present molecular biomarker records at subannual to annual resolution by mass spectrometry imaging (MSI) of sediments from the Lake Meerfelder Maar covering the Allerod-Younger Dryas transition. These analyses are supported by conventional extraction-based molecular-isotopic analyses, which both validate the imaging results and constrain the sources of the target compounds. The targeted fatty acid biomarkers serve as a gauge of the response of the local aquatic and terrestrial ecosystem to climate change. Based on the comparison of our data with existing data from Meerfelder Maar, we analyse the short-term environmental evolution in Western Europe during the studied time interval and confirm the previously reported delayed hydrological response to Greenland cooling. However, despite a detected delay of Western European environmental change of similar to 135 years, our biomarker data show statistically significant correlation with deuterium excess in Greenland ice core at - annual resolution during this time-transgressive cooling. This suggests a coherent atmospheric forcing across the North Atlantic realm during this transition. We propose that Western European cooling was postponed due to major reorganization of the westerlies that were intermittently forcing warmer and wetter air masses from lower latitudes to Western Europe and thus resulted in delayed cooling relative to Greenland.}, language = {en} } @article{HaaseThim2020, author = {Haase, Jennifer and Thim, Christof}, title = {An approach to model forgetting}, series = {AIS Transactions on Enterprise Systems}, volume = {4}, journal = {AIS Transactions on Enterprise Systems}, number = {1}, publisher = {Gito mbH Verlag f{\"u}r Industrielle Informationstechnik und Organisation}, address = {Berlin}, doi = {10.30844/aistes.v4i1.17}, pages = {12}, year = {2020}, abstract = {This paper aims to investigate the possibility to include aspects of forgetting into business process modeling. To date, there is no possibility to model forgotten or to-be- forgotten elements beyond the mere deletion. On a first attempt, we focus on the individual level and model knowledge transformation within a single person. Using the Knowledge Model Description Language, we propose ways to include different forms of forgetting into the realm of modeling tools. Using data from an experimental setting within an assembly line production environment, the usability of those new modeling tools is tested. So far, the applicability of modeling features for forgetting on the individual level is mostly restricted to a research context. However, clear requirements to transfer the tools onto the team- and organizational level are set out.}, language = {en} } @article{CiemerRehmKurthsetal.2020, author = {Ciemer, Catrin and Rehm, Lars and Kurths, J{\"u}rgen and Donner, Reik Volker and Winkelmann, Ricarda and Boers, Niklas}, title = {An early-warning indicator for Amazon droughts exclusively based on tropical Atlantic sea surface temperatures}, series = {Environmental Research Letters}, volume = {15}, journal = {Environmental Research Letters}, number = {9}, publisher = {IOP - Institute of Physics Publishing}, address = {Bristol}, pages = {10}, year = {2020}, abstract = {Droughts in tropical South America have an imminent and severe impact on the Amazon rainforest and affect the livelihoods of millions of people. Extremely dry conditions in Amazonia have been previously linked to sea surface temperature (SST) anomalies in the adjacent tropical oceans. Although the sources and impacts of such droughts have been widely studied, establishing reliable multi-year lead statistical forecasts of their occurrence is still an ongoing challenge. Here, we further investigate the relationship between SST and rainfall anomalies using a complex network approach. We identify four ocean regions which exhibit the strongest overall SST correlations with central Amazon rainfall, including two particularly prominent regions in the northern and southern tropical Atlantic. Based on the time-dependent correlation between SST anomalies in these two regions alone, we establish a new early-warning method for droughts in the central Amazon basin and demonstrate its robustness in hindcasting past major drought events with lead-times up to 18 months.}, language = {en} } @article{BaroniFrancke2020, author = {Baroni, Gabriele and Francke, Till}, title = {An effective strategy for combining variance- and distribution-based global sensitivity analysis}, series = {Environmental modelling \& software with environment data news}, volume = {134}, journal = {Environmental modelling \& software with environment data news}, publisher = {Elsevier}, address = {Oxford}, issn = {1364-8152}, doi = {10.1016/j.envsoft.2020.104851}, pages = {14}, year = {2020}, abstract = {We present a new strategy for performing global sensitivity analysis capable to estimate main and interaction effects from a generic sampling design. The new strategy is based on a meaningful combination of varianceand distribution-based approaches. The strategy is tested on four analytic functions and on a hydrological model. Results show that the analysis is consistent with the state-of-the-art Saltelli/Jansen formula but to better quantify the interaction effect between the input factors when the output distribution is skewed. Moreover, the estimation of the sensitivity indices is much more robust requiring a smaller number of simulations runs. Specific settings and alternative methods that can be integrated in the new strategy are also discussed. Overall, the strategy is considered as a new simple and effective tool for performing global sensitivity analysis that can be easily integrated in any environmental modelling framework.}, language = {en} } @article{AbdallaAdamAharonianetal.2020, author = {Abdalla, H. and Adam, R. and Aharonian, Felix A. and Benkhali, F. Ait and Ang{\"u}ner, Ekrem Oǧuzhan and Arcaro, C. and Armand, C. and Armstrong, T. and Ashkar, H. and Backes, M. and Baghmanyan, V. and Martins, V. Barbosa and Barnacka, A. and Barnard, M. and Becherini, Y. and Berge, D. and Bernlohr, K. and Bi, B. and Bottcher, M. and Boisson, C. and Bolmont, J. and de Lavergne, M. de Bony and Bordas, Pol and Breuhaus, M. and Brun, F. and Brun, P. and Bryan, M. and Buchele, M. and Bulik, T. and Bylund, T. and Caroff, S. and Carosi, A. and Casanova, Sabrina and Chand, T. and Chandra, S. and Chen, A. and Cotter, G. and Curylo, M. and Mbarubucyeye, J. Damascene and Davids, I. D. and Davies, J. and Deil, C. and Devin, J. and deWilt, P. and Dirson, L. and Djannati-Atai, A. and Dmytriiev, A. and Donath, A. and Doroshenko, V. and Duffy, C. and Dyks, J. and Egberts, Kathrin and Eichhorn, F. and Einecke, S. and Emery, G. and Ernenwein, J. -P. and Feijen, K. and Fegan, S. and Fiasson, A. and de Clairfontaine, G. Fichet and Fontaine, G. and Funk, S. and Fussling, Matthias and Gabici, S. and Gallant, Y. A. and Giavitto, G. and Giunti, L. and Glawion, D. and Glicenstein, J. F. and Gottschall, D. and Grondin, M. -H. and Hahn, J. and Haupt, M. and Hermann, G. and Hinton, J. A. and Hofmann, W. and Hoischen, Clemens and Holch, T. L. and Holler, M. and Horbe, M. and Horns, D. and Huber, D. and Jamrozy, M. and Jankowsky, D. and Jankowsky, F. and Jardin-Blicq, A. and Joshi, V. and Jung-Richardt, I. and Kasai, E. and Kastendieck, M. A. and Katarzynski, K. and Katz, U. and Khangulyan, D. and Khelifi, B. and Klepser, S. and Kluzniak, W. and Komin, Nu. and Konno, R. and Kosack, K. and Kostunin, D. and Kreter, M. and Lamanna, G. and Lemiere, A. and Lemoine-Goumard, M. and Lenain, J. -P. and Levy, C. and Lohse, T. and Lypova, I. and Mackey, J. and Majumdar, J. and Malyshev, D. and Malyshev, D. and Marandon, V. and Marchegiani, P. and Marcowith, Alexandre and Mares, A. and Marti-Devesa, G. and Marx, R. and Maurin, G. and Meintjes, P. J. and Meyer, M. and Mitchell, A. and Moderski, R. and Mohamed, M. and Mohrmann, L. and Montanari, A. and Moore, C. and Morris, P. and Moulin, Emmanuel and Muller, J. and Murach, T. and Nakashima, K. and Nayerhoda, A. and de Naurois, M. and Ndiyavala, H. and Niederwanger, F. and Niemiec, J. and Oakes, L. and O'Brien, Patrick and Odaka, H. and Ohm, S. and Olivera-Nieto, L. and Wilhelmi, E. de Ona and Ostrowski, M. and Oya, I. and Panter, M. and Panny, S. and Parsons, R. D. and Peron, G. and Peyaud, B. and Piel, Q. and Pita, S. and Poireau, V. and Noel, A. Priyana and Prokhorov, D. A. and Prokoph, H. and Puhlhofer, G. and Punch, M. and Quirrenbach, A. and Raab, S. and Rauth, R. and Reichherzer, P. and Reimer, A. and Reimer, O. and Remy, Q. and Renaud, M. and Rieger, F. and Rinchiuso, L. and Romoli, C. and Rowell, G. and Rudak, B. and Ruiz-Velasco, E. and Sahakian, V. and Sailer, S. and Sanchez, D. A. and Santangelo, Andrea and Sasaki, M. and Scalici, M. and Schussler, F. and Schutte, H. M. and Schwanke, U. and Schwemmer, S. and Seglar-Arroyo, M. and Senniappan, M. and Seyffert, A. S. and Shafi, N. and Shiningayamwe, K. and Simoni, R. and Sinha, A. and Sol, H. and Specovius, A. and Spencer, S. and Spir-Jacob, M. and Stawarz, L. and Sun, L. and Steenkamp, R. and Stegmann, C. and Steinmassl, S. and Steppa, C. and Takahashi, T. and Tavernier, T. and Taylor, A. M. and Terrier, R. and Tiziani, D. and Tluczykont, M. and Tomankova, L. and Trichard, C. and Tsirou, M. and Tuffs, R. and Uchiyama, Y. and van der Walt, D. J. and van Eldik, C. and van Rensburg, C. and van Soelen, B. and Vasileiadis, G. and Veh, J. and Venter, C. and Vincent, P. and Vink, J. and Volk, H. J. and Vuillaume, T. and Wadiasingh, Z. and Wagner, S. J. and Watson, J. and Werner, F. and White, R. and Wierzcholska, A. and Wong, Yu Wun and Yusafzai, A. and Zacharias, M. and Zanin, R. and Zargaryan, D. and Zdziarski, A. A. and Zech, Alraune and Zhu, S. J. and Ziegler, A. and Zorn, J. and Zouari, S. and Zywucka, N.}, title = {An extreme particle accelerator in the Galactic plane}, series = {Astronomy and astrophysics : an international weekly journal}, volume = {644}, journal = {Astronomy and astrophysics : an international weekly journal}, publisher = {EDP Sciences}, address = {Les Ulis}, organization = {HESS Collaboration}, issn = {0004-6361}, doi = {10.1051/0004-6361/202038851}, pages = {8}, year = {2020}, abstract = {The unidentified very-high-energy (VHE; E > 0.1 TeV) gamma -ray source, HESS J1826-130, was discovered with the High Energy Stereoscopic System (HESS) in the Galactic plane. The analysis of 215 h of HESS data has revealed a steady gamma -ray flux from HESS J1826-130, which appears extended with a half-width of 0.21 degrees +/- 0.02
(stat)degrees
stat degrees +/- 0.05
(sys)degrees sys degrees . The source spectrum is best fit with either a power-law function with a spectral index Gamma = 1.78 +/- 0.10(stat) +/- 0.20(sys) and an exponential cut-off at 15.2
(+5.5)(-3.2) -3.2+5.5 TeV, or a broken power-law with Gamma (1) = 1.96 +/- 0.06(stat) +/- 0.20(sys), Gamma (2) = 3.59 +/- 0.69(stat) +/- 0.20(sys) for energies below and above E-br = 11.2 +/- 2.7 TeV, respectively. The VHE flux from HESS J1826-130 is contaminated by the extended emission of the bright, nearby pulsar wind nebula, HESS J1825-137, particularly at the low end of the energy spectrum. Leptonic scenarios for the origin of HESS J1826-130 VHE emission related to PSR J1826-1256 are confronted by our spectral and morphological analysis. In a hadronic framework, taking into account the properties of dense gas regions surrounding HESS J1826-130, the source spectrum would imply an astrophysical object capable of accelerating the parent particle population up to greater than or similar to 200 TeV. Our results are also discussed in a multiwavelength context, accounting for both the presence of nearby supernova remnants, molecular clouds, and counterparts detected in radio, X-rays, and TeV energies.}, language = {en} } @article{KirchnerPenning2020, author = {Kirchner, Vera and Penning, Isabelle}, title = {An Fragen wachsen}, series = {Forschendes Lernen}, journal = {Forschendes Lernen}, publisher = {Klinkhardt}, address = {Bad Heilbrunn}, isbn = {978-3-7815-2420-0}, pages = {44 -- 56}, year = {2020}, language = {de} } @article{KirchnerPenning2020, author = {Kirchner, Vera and Penning, Isabelle}, title = {An Fragen wachsen - Forschendes Lernen in der technischen und {\"o}konomischen Bildung}, series = {transfer. Forschung ↔ Schule}, journal = {transfer. Forschung ↔ Schule}, number = {6}, publisher = {Klinkhardt}, address = {Bad Heilbrunn}, pages = {44 -- 56}, year = {2020}, language = {de} } @article{EsfahaniGholamiOhrnberger2020, author = {Esfahani, Reza Dokht Dolatabadi and Gholami, Ali and Ohrnberger, Matthias}, title = {An inexact augmented Lagrangian method for nonlinear dispersion-curve inversion using Dix-type global linear approximation}, series = {Geophysics : a journal of general and applied geophysics}, volume = {85}, journal = {Geophysics : a journal of general and applied geophysics}, number = {3}, publisher = {GeoScienceWorld}, address = {Tulsa, Okla.}, issn = {0016-8033}, doi = {10.1190/geo2019-0717.1}, pages = {EN77 -- EN85}, year = {2020}, abstract = {Dispersion-curve inversion of Rayleigh waves to infer subsurface shear-wave velocity is a long-standing problem in seismology. Due to nonlinearity and ill-posedness, sophisticated regularization techniques are required to solve the problem for a stable velocity model. We have formulated the problem as a minimization problem with nonlinear operator constraint and then solve it by using an inexact augmented Lagrangian method, taking advantage of the Haney-Tsai Dix-type relation (a global linear approximation of the nonlinear forward operator). This replaces the original regularized nonlinear problem with iterative minimization of a more tractable regularized linear problem followed by a nonlinear update of the phase velocity (data) in which the update can be performed accurately with any forward modeling engine, for example, the finite-element method. The algorithm allows discretizing the medium with thin layers (for the finite-element method) and thus omitting the layer thicknesses from the unknowns and also allows incorporating arbitrary regularizations to shape the desired velocity model. In this research, we use total variation regularization to retrieve the shear-wave velocity model. We use two synthetic and two real data examples to illustrate the performance of the inversion algorithm with total variation regularization. We find that the method is fast and stable, and it converges to the solution of the original nonlinear problem.}, language = {en} } @article{HeHoeperDodenhoeftetal.2020, author = {He, Hai and H{\"o}per, Rune and Dodenh{\"o}ft, Moritz and Marli{\`e}re, Philippe and Bar-Even, Arren}, title = {An optimized methanol assimilation pathway relying on promiscuous formaldehyde-condensing aldolases in E. coli}, series = {Metabolic Engineering}, volume = {60}, journal = {Metabolic Engineering}, publisher = {Elsevier}, address = {Amsterdam [u.a.]}, issn = {1096-7176}, doi = {10.1016/j.ymben.2020.03.002}, pages = {1 -- 13}, year = {2020}, abstract = {Engineering biotechnological microorganisms to use methanol as a feedstock for bioproduction is a major goal for the synthetic metabolism community. Here, we aim to redesign the natural serine cycle for implementation in E. coli. We propose the homoserine cycle, relying on two promiscuous formaldehyde aldolase reactions, as a superior pathway design. The homoserine cycle is expected to outperform the serine cycle and its variants with respect to biomass yield, thermodynamic favorability, and integration with host endogenous metabolism. Even as compared to the RuMP cycle, the most efficient naturally occurring methanol assimilation route, the homoserine cycle is expected to support higher yields of a wide array of products. We test the in vivo feasibility of the homoserine cycle by constructing several E. coli gene deletion strains whose growth is coupled to the activity of different pathway segments. Using this approach, we demonstrate that all required promiscuous enzymes are active enough to enable growth of the auxotrophic strains. Our findings thus identify a novel metabolic solution that opens the way to an optimized methylotrophic platform.}, language = {en} } @article{QinFaassNiedermeier2020, author = {Qin, Xia and Faaß, Marcel and Niedermeier, Frank}, title = {An Overview of the 'National Multiplication Trainings' Programme}, series = {Potsdamer Beitr{\"a}ge zur Hochschulforschung}, journal = {Potsdamer Beitr{\"a}ge zur Hochschulforschung}, number = {5}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-496-8}, issn = {2192-1075}, doi = {10.25932/publishup-49334}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-493344}, pages = {17 -- 35}, year = {2020}, abstract = {The article introduces the efforts exerted to initiate multiplication of the DIES training courses to a wider audience of higher education managers and academics in the target regions. The DIES 'National Multiplication Trainings' Programme has supported three cohorts of alumni teams so far to implement national training courses in the area of higher education leadership and management. The article sets the context of this publication and reflects on the main evaluation results of the programme implementation itself.}, language = {en} } @article{FuehnerKlieglArntzetal.2020, author = {F{\"u}hner, Thea Heidi and Kliegl, Reinhold and Arntz, Fabian and Kriemler, Susi and Granacher, Urs}, title = {An update on secular trends in physical fitness of children and adolescents from 1972 to 2015}, series = {Sports medicine}, volume = {51}, journal = {Sports medicine}, number = {2}, publisher = {Springer}, address = {Northcote}, issn = {0112-1642}, doi = {10.1007/s40279-020-01373-x}, pages = {303 -- 320}, year = {2020}, abstract = {Background There is evidence that physical fitness of children and adolescents (particularly cardiorespiratory endurance) has declined globally over the past decades. Ever since the first reports on negative trends in physical fitness, efforts have been undertaken by for instance the World Health Organization (WHO) to promote physical activity and fitness in children and adolescents. Therefore, it is timely to re-analyze the literature to examine whether previous reports on secular declines in physical fitness are still detectable or whether they need to be updated. Objectives The objective of this systematic review is to provide an 'update' on secular trends in selected components of physical fitness (i.e., cardiorespiratory endurance, relative muscle strength, proxies of muscle power, speed) in children and adolescents aged 6-18 years. Data Sources A systematic computerized literature search was conducted in the electronic databases PubMed and Web of Science to locate studies that explicitly reported secular trends in physical fitness of children and adolescents. Study Eligibility Criteria Studies were included in this systematic review if they examined secular trends between at least two time points across a minimum of 5 years. In addition, they had to document secular trends in any measure of cardiorespiratory endurance, relative muscle strength, proxies of muscle power or speed in apparently healthy children and adolescents aged 6-18 years. Study Appraisal and Synthesis Methods The included studies were coded for the following criteria: nation, physical fitness component (cardiorespiratory endurance, relative muscle strength, proxies of muscle power, speed), chronological age, sex (boys vs. girls), and year of assessment. Scores were standardized (i.e., converted to z scores) with sample-weighted means and standard deviations, pooled across sex and year of assessment within cells defined by study, test, and children's age. Results The original search identified 524 hits. In the end, 22 studies met the inclusion criteria for review. The observation period was between 1972 and 2015. Fifteen of the 22 studies used tests for cardiorespiratory endurance, eight for relative muscle strength, eleven for proxies of muscle power, and eight for speed. Measures of cardiorespiratory endurance exhibited a large initial increase and an equally large subsequent decrease, but the decrease appears to have reached a floor for all children between 2010 and 2015. Measures of relative muscle strength showed a general trend towards a small increase. Measures of proxies of muscle power indicated an overall small negative quadratic trend. For measures of speed, a small-to-medium increase was observed in recent years. Limitations Biological maturity was not considered in the analysis because biological maturity was not reported in most included studies. Conclusions Negative secular trends were particularly found for cardiorespiratory endurance between 1986 and 2010-12, irrespective of sex. Relative muscle strength and speed showed small increases while proxies of muscle power declined. Although the negative trend in cardiorespiratory endurance appears to have reached a floor in recent years, because of its association with markers of health, we recommend further initiatives in PA and fitness promotion for children and adolescents. More specifically, public health efforts should focus on exercise that increases cardiorespiratory endurance to prevent adverse health effects (i.e.
, overweight and obesity) and muscle strength to lay a foundation for motor skill learning.}, language = {en} } @article{MilewskiChabrillatBookhagen2020, author = {Milewski, Robert and Chabrillat, Sabine and Bookhagen, Bodo}, title = {Analyses of Namibian Seasonal Salt Pan Crust Dynamics and Climatic Drivers Using Landsat 8 Time-Series and Ground Data}, series = {Remote Sensing}, journal = {Remote Sensing}, number = {3}, publisher = {MDPI}, address = {Basel}, issn = {2072-4292}, doi = {10.3390/rs12030474}, pages = {24}, year = {2020}, abstract = {Salt pans are highly dynamic environments that are difficult to study by in situ methods because of their harsh climatic conditions and large spatial areas. Remote sensing can help to elucidate their environmental dynamics and provide important constraints regarding their sedimentological, mineralogical, and hydrological evolution. This study utilizes spaceborne multitemporal multispectral optical data combined with spectral endmembers to document spatial distribution of surface crust types over time on the Omongwa pan located in the Namibian Kalahari. For this purpose, 49 surface samples were collected for spectral and mineralogical characterization during three field campaigns (2014-2016) reflecting different seasons and surface conditions of the salt pan. An approach was developed to allow the spatiotemporal analysis of the salt pan crust dynamics in a dense time-series consisting of 77 Landsat 8 cloud-free scenes between 2014 and 2017, covering at least three major wet-dry cycles. The established spectral analysis technique Sequential Maximum Angle Convex Cone (SMACC) extraction method was used to derive image endmembers from the Landsat time-series stack. Evaluation of the extracted endmember set revealed that the multispectral data allowed the differentiation of four endmembers associated with mineralogical mixtures of the crust's composition in dry conditions and three endmembers associated with flooded or muddy pan conditions. The dry crust endmember spectra have been identified in relation to visible, near infrared, and short-wave infrared (VNIR-SWIR) spectroscopy and X-ray diffraction (XRD) analyses of the collected surface samples. According these results, the spectral endmembers are interpreted as efflorescent halite crust, mixed halite-gypsum crust, mixed calcite quartz sepiolite crust, and gypsum crust. For each Landsat scene the spatial distribution of these crust types was mapped with the Spectral Angle Mapper (SAM) method and significant spatiotemporal dynamics of the major surface crust types were observed. Further, the surface crust dynamics were analyzed in comparison with the pan's moisture regime and other climatic parameters. The results show that the crust dynamics are mainly driven by flooding events in the wet season, but are also influenced by temperature and aeolian activity in the dry season. The approach utilized in this study combines the advantages of multitemporal satellite data for temporal event characterization with advantages from hyperspectral methods for the image and ground data analyses that allow improved mineralogical differentiation and characterization.}, language = {en} } @article{WiljesTong2020, author = {Wiljes, Jana de and Tong, Xin T.}, title = {Analysis of a localised nonlinear ensemble Kalman Bucy filter with complete and accurate observations}, series = {Nonlinearity}, volume = {33}, journal = {Nonlinearity}, number = {9}, publisher = {IOP Publ.}, address = {Bristol}, issn = {0951-7715}, doi = {10.1088/1361-6544/ab8d14}, pages = {4752 -- 4782}, year = {2020}, abstract = {Concurrent observation technologies have made high-precision real-time data available in large quantities. Data assimilation (DA) is concerned with how to combine this data with physical models to produce accurate predictions. For spatial-temporal models, the ensemble Kalman filter with proper localisation techniques is considered to be a state-of-the-art DA methodology. This article proposes and investigates a localised ensemble Kalman Bucy filter for nonlinear models with short-range interactions. We derive dimension-independent and component-wise error bounds and show the long time path-wise error only has logarithmic dependence on the time range. The theoretical results are verified through some simple numerical tests.}, language = {en} } @article{SchenkeSchjeidePuescheletal.2020, author = {Schenke, Maren and Schjeide, Brit-Maren and P{\"u}schel, Gerhard Paul and Seeger, Bettina}, title = {Analysis of motor neurons differentiated from human induced pluripotent stem cells for the use in cell-based Botulinum neurotoxin activity assays}, series = {Toxins}, volume = {12}, journal = {Toxins}, number = {5}, publisher = {MDPI}, address = {Basel}, issn = {2072-6651}, doi = {10.3390/toxins12050276}, pages = {20}, year = {2020}, abstract = {Botulinum neurotoxins (BoNTs) are potent neurotoxins produced by bacteria, which inhibit neurotransmitter release, specifically in their physiological target known as motor neurons (MNs). For the potency assessment of BoNTs produced for treatment in traditional and aesthetic medicine, the mouse lethality assay is still used by the majority of manufacturers, which is ethically questionable in terms of the 3Rs principle. In this study, MNs were differentiated from human induced pluripotent stem cells based on three published protocols. The resulting cell populations were analyzed for their MN yield and their suitability for the potency assessment of BoNTs. MNs produce specific gangliosides and synaptic proteins, which are bound by BoNTs in order to be taken up by receptor-mediated endocytosis, which is followed by cleavage of specific soluble N-ethylmaleimide-sensitive-factor attachment receptor (SNARE) proteins required for neurotransmitter release. The presence of receptors and substrates for all BoNT serotypes was demonstrated in MNs generated in vitro. In particular, the MN differentiation protocol based on Du et al. yielded high numbers of MNs in a short amount of time with high expression of BoNT receptors and targets. The resulting cells are more sensitive to BoNT/A1 than the commonly used neuroblastoma cell line SiMa. MNs are, therefore, an ideal tool for being combined with already established detection methods.}, language = {en} } @article{KocPetrowThieken2020, author = {Koc, Gamze and Petrow, Theresia and Thieken, Annegret}, title = {Analysis of the most severe flood events in Turkey (1960-2014)}, series = {Water / Molecular Diversity Preservation International (MDPI)}, volume = {12}, journal = {Water / Molecular Diversity Preservation International (MDPI)}, number = {6}, publisher = {MDPI}, address = {Basel}, issn = {2073-4441}, doi = {10.3390/w12061562}, pages = {32}, year = {2020}, abstract = {The most severe flood events in Turkey were determined for the period 1960-2014 by considering the number of fatalities, the number of affected people, and the total economic losses as indicators. The potential triggering mechanisms (i.e., atmospheric circulations and precipitation amounts) and aggravating pathways (i.e., topographic features, catchment size, land use types, and soil properties) of these 25 events were analyzed. On this basis, a new approach was developed to identify the main influencing factor per event and to provide additional information for determining the dominant flood occurrence pathways for severe floods. The events were then classified through hierarchical cluster analysis. As a result, six different clusters were found and characterized. Cluster 1 comprised flood events that were mainly influenced by drainage characteristics (e.g., catchment size and shape); Cluster 2 comprised events aggravated predominantly by urbanization; steep topography was identified to be the dominant factor for Cluster 3; extreme rainfall was determined as the main triggering factor for Cluster 4; saturated soil conditions were found to be the dominant factor for Cluster 5; and orographic effects of mountain ranges characterized Cluster 6. This study determined pathway patterns of the severe floods in Turkey with regard to their main causal or aggravating mechanisms. Accordingly, geomorphological properties are of major importance in large catchments in eastern and northeastern Anatolia. In addition, in small catchments, the share of urbanized area seems to be an important factor for the extent of flood impacts. This paper presents an outcome that could be used for future urban planning and flood risk prevention studies to understand the flood mechanisms in different regions of Turkey.}, language = {en} } @article{KocPetrowThieken2020, author = {Ko{\c{c}}, Gamze and Petrow, Theresia and Thieken, Annegret}, title = {Analysis of the Most Severe Flood Events in Turkey (1960-2014)}, series = {Water}, volume = {12}, journal = {Water}, number = {6}, publisher = {MDPI}, address = {Basel}, issn = {2073-4441}, doi = {10.3390/w12061562}, pages = {32}, year = {2020}, abstract = {The most severe flood events in Turkey were determined for the period 1960-2014 by considering the number of fatalities, the number of affected people, and the total economic losses as indicators. The potential triggering mechanisms (i.e., atmospheric circulations and precipitation amounts) and aggravating pathways (i.e., topographic features, catchment size, land use types, and soil properties) of these 25 events were analyzed. On this basis, a new approach was developed to identify the main influencing factor per event and to provide additional information for determining the dominant flood occurrence pathways for severe floods. The events were then classified through hierarchical cluster analysis. As a result, six different clusters were found and characterized. Cluster 1 comprised flood events that were mainly influenced by drainage characteristics (e.g., catchment size and shape); Cluster 2 comprised events aggravated predominantly by urbanization; steep topography was identified to be the dominant factor for Cluster 3; extreme rainfall was determined as the main triggering factor for Cluster 4; saturated soil conditions were found to be the dominant factor for Cluster 5; and orographic effects of mountain ranges characterized Cluster 6. This study determined pathway patterns of the severe floods in Turkey with regard to their main causal or aggravating mechanisms. Accordingly, geomorphological properties are of major importance in large catchments in eastern and northeastern Anatolia. In addition, in small catchments, the share of urbanized area seems to be an important factor for the extent of flood impacts. This paper presents an outcome that could be used for future urban planning and flood risk prevention studies to understand the flood mechanisms in different regions of Turkey.}, language = {en} } @article{MunyaevSmirnovKostinetal.2020, author = {Munyaev, Vyacheslav O. and Smirnov, Lev A. and Kostin, Vasily A. and Osipov, Grigory V. and Pikovskij, Arkadij}, title = {Analytical approach to synchronous states of globally coupled noisy rotators}, series = {New journal of physics : the open-access journal for physics}, volume = {22}, journal = {New journal of physics : the open-access journal for physics}, number = {2}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {1367-2630}, doi = {10.1088/1367-2630/ab6f93}, pages = {14}, year = {2020}, abstract = {We study populations of globally coupled noisy rotators (oscillators with inertia) allowing a nonequilibrium transition from a desynchronized state to a synchronous one (with the nonvanishing order parameter). The newly developed analytical approaches resulted in solutions describing the synchronous state with constant order parameter for weakly inertial rotators, including the case of zero inertia, when the model is reduced to the Kuramoto model of coupled noise oscillators. These approaches provide also analytical criteria distinguishing supercritical and subcritical transitions to the desynchronized state and indicate the universality of such transitions in rotator ensembles. All the obtained analytical results are confirmed by the numerical ones, both by direct simulations of the large ensembles and by solution of the associated Fokker-Planck equation. We also propose generalizations of the developed approaches for setups where different rotators parameters (natural frequencies, masses, noise intensities, strengths and phase shifts in coupling) are dispersed.}, language = {en} } @article{MunyaevSmirnovKostinetal.2020, author = {Munyaev, Vyacheslav and Smirnov, Lev A. and Kostin, Vasily and Osipov, Grigory V. and Pikovskij, Arkadij}, title = {Analytical approach to synchronous states of globally coupled noisy rotators}, series = {New Journal of Physics}, volume = {22}, journal = {New Journal of Physics}, number = {2}, publisher = {Springer Science}, address = {New York}, pages = {15}, year = {2020}, abstract = {We study populations of globally coupled noisy rotators (oscillators with inertia) allowing a nonequilibrium transition from a desynchronized state to a synchronous one (with the nonvanishing order parameter). The newly developed analytical approaches resulted in solutions describing the synchronous state with constant order parameter for weakly inertial rotators, including the case of zero inertia, when the model is reduced to the Kuramoto model of coupled noise oscillators. These approaches provide also analytical criteria distinguishing supercritical and subcritical transitions to the desynchronized state and indicate the universality of such transitions in rotator ensembles. All the obtained analytical results are confirmed by the numerical ones, both by direct simulations of the large ensembles and by solution of the associated Fokker-Planck equation. We also propose generalizations of the developed approaches for setups where different rotators parameters (natural frequencies, masses, noise intensities, strengths and phase shifts in coupling) are dispersed.}, language = {en} } @article{ZhangYangJomaaetal.2020, author = {Zhang, Xiaolin and Yang, Xiaoqiang and Jomaa, Seifeddine and Rode, Michael}, title = {Analyzing impacts of seasonality and landscape gradient on event-scale nitrate-discharge dynamics based on nested high-frequency monitoring}, series = {Journal of hydrology}, volume = {591}, journal = {Journal of hydrology}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0022-1694}, doi = {10.1016/j.jhydrol.2020.125585}, pages = {12}, year = {2020}, abstract = {Increasingly available high-frequency data during storm events, when hydrological dynamics most likely activate nitrate storage-flux exchanges, reveal insights into catchment nitrate dynamics. In this study, we explored impacts of seasonality and landscape gradients on nitrate concentration-discharge (C-Q) hysteresis patterns in the Selke catchment, central Germany, which has heterogeneous combinations of meteorological, hydrogeological and land use conditions. Three nested gauging stations established along the main Selke River captured flow and nitrate export dynamics from the uppermost subcatchment (mixed forest and arable land), middle subcatchment (pure steep forest) and lowermost subcatchment (arable and urban land). We collected continuous high-frequency (15-min) discharge and nitrate concentration data from 2012 to 2017 and analyzed the 223 events detected at all three stations. A dominant hysteresis pattern in the uppermost and middle subcatchments was counter-clockwise and combined with an accretion effect, indicating many proximal and mobilized distal nitrate sources. However, 66\% of all events at the catchment outlet experienced a dilution effect, possibly due to mechanisms that vary seasonally. During wetting/wet periods (October-March), it was combined mainly with a counter-clockwise pattern due to the dominance of event runoff volume from the uppermost and middle subcatchments. During drying/dry periods (April-September), however, it was combined mainly with a clockwise pattern due to occasional quick surface flows from lowland near-stream urban areas. In addition, the clockwise hysteresis occurred mainly from May-October during mostly drying/dry periods at all three sites, indicating little distal nitrate transport in response to the low terrestrial hydrological connectivity, especially in the lowermost dry and flat sub-catchment. This comprehensive analysis (i.e., clockwise vs. counter-clockwise, accretion vs. dilution) enables in-depth analysis of nitrate export mechanisms during certain periods under different landscape conditions. Specific combination of C-Q relationships could identify target locations for agricultural management actions that decrease nitrate output. Therefore, we strongly encourage long-term multisite and high-frequency monitoring strategies in heterogeneous nested catchment(s), which can help understand process mechanisms, generate data for physical-based water-quality modeling and provide guidance for water and agricultural management.}, language = {en} } @article{PaijmansBarlowHennebergeretal.2020, author = {Paijmans, Johanna L. A. and Barlow, Axel and Henneberger, Kirstin and Fickel, J{\"o}rns and Hofreiter, Michael and Foerste, Daniel W. G.}, title = {Ancestral mitogenome capture of the Southeast Asian banded linsang}, series = {PLoS ONE}, volume = {15}, journal = {PLoS ONE}, number = {6}, publisher = {PLOS}, address = {San Francisco, California, US}, issn = {1932-6203}, doi = {10.1371/journal.pone.0234385}, pages = {12}, year = {2020}, abstract = {Utilising a reconstructed ancestral mitochondrial genome of a clade to design hybridisation capture baits can provide the opportunity for recovering mitochondrial sequences from all its descendent and even sister lineages. This approach is useful for taxa with no extant close relatives, as is often the case for rare or extinct species, and is a viable approach for the analysis of historical museum specimens. Asiatic linsangs (genus Prionodon) exemplify this situation, being rare Southeast Asian carnivores for which little molecular data is available. Using ancestral capture we recover partial mitochondrial genome sequences for seven banded linsangs (P. linsang) from historical specimens, representing the first intraspecific genetic dataset for this species. We additionally assemble a high quality mitogenome for the banded linsang using shotgun sequencing for time-calibrated phylogenetic analysis. This reveals a deep divergence between the two Asiatic linsang species (P. linsang, P. pardicolor), with an estimated divergence of ~12 million years (Ma). Although our sample size precludes any robust interpretation of the population structure of the banded linsang, we recover two distinct matrilines with an estimated tMRCA of ~1 Ma. Our results can be used as a basis for further investigation of the Asiatic linsangs, and further demonstrate the utility of ancestral capture for studying divergent taxa without close relatives.}, language = {en} } @article{Lehnert2020, author = {Lehnert, Gertrud}, title = {Andere R{\"a}ume : Pupenh{\"a}user}, series = {Materielle Miniaturen : zur {\"A}sthetik der Verkleinerung}, journal = {Materielle Miniaturen : zur {\"A}sthetik der Verkleinerung}, publisher = {K{\"o}nigshausen \& Neumann}, address = {W{\"u}rzburg}, isbn = {978-3-8260-6679-5}, pages = {57 -- 74}, year = {2020}, language = {de} } @article{Steinroetter2020, author = {Steinr{\"o}tter, Bj{\"o}rn}, title = {Anforderungen an die Einwilligung des Internetnutzers beim Setzen und Auslesen von Cookies}, series = {Zeitschrift f{\"u}r das Privatrecht der Europ{\"a}ischen Union}, volume = {17}, journal = {Zeitschrift f{\"u}r das Privatrecht der Europ{\"a}ischen Union}, number = {3}, publisher = {Dr. Otto Schmidt}, address = {K{\"o}ln}, issn = {2364-7205}, doi = {10.9785/gpr-2020-170303}, pages = {106 -- 111}, year = {2020}, language = {de} } @article{DuffusSchrapersSchuthetal.2020, author = {Duffus, Benjamin R. and Schrapers, Peer and Schuth, Nils and Mebs, Stefan and Dau, Holger and Leimk{\"u}hler, Silke and Haumann, Michael}, title = {Anion binding and oxidative modification at the molybdenum cofactor of formate dehydrogenase from Rhodobacter capsulatus studied by X-ray absorption spectroscopy}, series = {Inorganic chemistry}, volume = {59}, journal = {Inorganic chemistry}, number = {1}, publisher = {American Chemical Society}, address = {Washington, DC}, issn = {0020-1669}, doi = {10.1021/acs.inorgchem.9b01613}, pages = {214 -- 225}, year = {2020}, abstract = {Formate dehydrogenase (FDH) enzymes are versatile catalysts for CO2 conversion. The FDH from Rhodobacter capsulatus contains a molybdenum cofactor with the dithiolene functions of two pyranopterin guanine dinucleotide molecules, a conserved cysteine, and a sulfido group bound at Mo(VI). In this study, we focused on metal oxidation state and coordination changes in response to exposure to O-2, inhibitory anions, and redox agents using X-ray absorption spectroscopy (XAS) at the Mo K-edge. Differences in the oxidative modification of the bis-molybdopterin guanine dinucleotide (bis-MGD) cofactor relative to samples prepared aerobically without inhibitor, such as variations in the relative numbers of sulfido (Mo=S) and oxo (Mo=O) bonds, were observed in the presence of azide (N-3(-)) or cyanate (OCN-). Azide provided best protection against O-2, resulting in a quantitatively sulfurated cofactor with a displaced cysteine ligand and optimized formate oxidation activity. Replacement of the cysteine ligand by a formate (HCO2-) ligand at the molybdenum in active enzyme is compatible with our XAS data. Cyanide (CN-) inactivated the enzyme by replacing the sulfido ligand at Mo(VI) with an oxo ligand. Evidence that the sulfido group may become protonated upon molybdenum reduction was obtained. Our results emphasize the role of coordination flexibility at the molybdenum center during inhibitory and catalytic processes of FDH enzymes.}, language = {en} } @article{GlatzelNoackSchanzenbachetal.2020, author = {Glatzel, Julia and Noack, Sebastian and Schanzenbach, Dirk and Schlaad, Helmut}, title = {Anionic polymerization of dienes in 'green' solvents}, series = {Polymer international}, volume = {70}, journal = {Polymer international}, number = {2}, publisher = {Wiley}, address = {Hoboken}, issn = {0959-8103}, doi = {10.1002/pi.6152}, pages = {181 -- 184}, year = {2020}, abstract = {Isoprene and beta-myrcene were polymerized by anionic polymerization in bulk and in the 'green' ether solvents cyclopentyl methyl ether and 2-methyltetrahydrofuran and, for comparison, in cyclohexane and tetrahydrofuran. The polydienes produced in bulk and in cyclohexane contained high amounts of 1,4 units (>90\%) whereas those produced in ether solvents were rich in 1,2 and 3,4 units (36\%-86\%). Comparison of the microstructures and glass transition temperatures of the polydienes obtained in the various solvents suggests that conventionally used solvents can be substituted by environmentally more friendly alternatives.}, language = {en} } @article{Lampart2020, author = {Lampart, Fabian}, title = {Anmerkungen zum Konzept der Funktionslosigkeit in Lyrikdebatten der 1950er und 1960er Jahre}, series = {Grundfragen der Lyrikologie. Bd. 2. Begriffe, Methoden und Analysedimensionen}, journal = {Grundfragen der Lyrikologie. Bd. 2. Begriffe, Methoden und Analysedimensionen}, editor = {Hillebrandt, Claudia and Klimek, Sonja and M{\"u}ller, Ralph and Zymner, R{\"u}diger}, publisher = {de Gruyter}, address = {Berlin, Boston}, isbn = {978-3-11-045687-5}, pages = {177 -- 195}, year = {2020}, language = {de} } @article{HartmannPreickAbeltetal.2020, author = {Hartmann, Stefanie and Preick, Michaela and Abelt, Silke and Scheffel, Andr{\´e} and Hofreiter, Michael}, title = {Annotated genome sequences of the carnivorous plant Roridula gorgonias and a non-carnivorous relative, Clethra arborea}, series = {BMC Research Notes}, volume = {13}, journal = {BMC Research Notes}, publisher = {Biomed Central}, address = {London}, issn = {1756-0500}, doi = {10.1186/s13104-020-05254-4}, pages = {6}, year = {2020}, abstract = {Objective Plant carnivory is distributed across the tree of life and has evolved at least six times independently, but sequenced and annotated nuclear genomes of carnivorous plants are currently lacking. We have sequenced and structurally annotated the nuclear genome of the carnivorous Roridula gorgonias and that of a non-carnivorous relative, Madeira's lily-of-the-valley-tree, Clethra arborea, both within the Ericales. This data adds an important resource to study the evolutionary genetics of plant carnivory across angiosperm lineages and also for functional and systematic aspects of plants within the Ericales. Results Our assemblies have total lengths of 284 Mbp (R. gorgonias) and 511 Mbp (C. arborea) and show high BUSCO scores of 84.2\% and 89.5\%, respectively. We used their predicted genes together with publicly available data from other Ericales' genomes and transcriptomes to assemble a phylogenomic data set for the inference of a species tree. However, groups of orthologs showed a marked absence of species represented by a transcriptome. We discuss possible reasons and caution against combining predicted genes from genome- and transriptome-based assemblies.}, language = {en} } @article{BrunelloAndermannMarcetal.2020, author = {Brunello, Camilla Francesca and Andermann, Christoff and Marc, Odin and Schneider, Katharina A. and Comiti, Francesco and Achleitner, Stefan and Hovius, Niels}, title = {Annually resolved monsoon onset and withdrawal dates across the Himalayas derived from local precipitation statistics}, series = {Geophysical research letters}, volume = {47}, journal = {Geophysical research letters}, number = {23}, publisher = {American Geophysical Union}, address = {Washington}, issn = {0094-8276}, doi = {10.1029/2020GL088420}, pages = {12}, year = {2020}, abstract = {A local and flexible definition of the monsoon season based on hydrological evidence is important for the understanding and management of Himalayan water resources. Here, we present an objective statistical method to retrieve seasonal hydrometeorological transitions. Applied to daily rainfall data (1951-2015), this method shows an average longitudinal delay of similar to 15 days, with later monsoon onset and earlier withdrawal in the western Himalaya, consistent with the continental progression of wet air masses. This delay leads to seasons of different length along the Himalaya and biased precipitation amounts when using uniform calendric monsoon boundaries. In the Central Himalaya annual precipitation has increased, due primarily to an increase of premonsoon precipitation. These findings highlight issues associated with a static definition of monsoon boundaries and call for a deeper understanding of nonmonsoonal precipitation over the Himalayan water tower.
Plain Language Summary Precipitation in the Himalayas determines water availability for the Indian foreland with large socioeconomic implications. Despite its importance, spatial and temporal patterns of precipitation are poorly understood. Here, we estimate the long-term average and trends of seasonal precipitation at the scale of individual catchments draining the Himalayas. We apply a statistical method to detect the timing of hydrometeorological seasons from local precipitation measurements, focusing on monsoon onset and withdrawal. We identify longitudinal and latitudinal delays, resulting in seasons of different length along and across the Himalayas. These spatial patterns and the annual variability of the monsoon boundaries mean that oft-used, fixed calendric dates, for example, 1 June to 30 September, may be inadequate for retrieving monsoon rainfall totals. Moreover, we find that, despite its prominent contribution to annual rainfall totals, the Indian summer monsoon cannot explain the increase of the annual precipitation over the Central Himalayas. Instead, this appears to be mostly driven by changes in premonsoon and winter rainfall. So far, little attention has been paid to premonsoon precipitation, but governed by evaporative processes and surface water availability, it may be enhanced by irrigation and changed land use in the Gangetic foreland.}, language = {en} } @article{WangCherstvyLiuetal.2020, author = {Wang, Wei and Cherstvy, Andrey G. and Liu, Xianbin and Metzler, Ralf}, title = {Anomalous diffusion and nonergodicity for heterogeneous diffusion processes with fractional Gaussian noise}, series = {Physical review : E, Statistical, nonlinear and soft matter physics}, volume = {102}, journal = {Physical review : E, Statistical, nonlinear and soft matter physics}, number = {1}, publisher = {American Physical Society}, address = {College Park}, issn = {2470-0045}, doi = {10.1103/PhysRevE.102.012146}, pages = {012146-1 -- 012146-16}, year = {2020}, abstract = {Heterogeneous diffusion processes (HDPs) feature a space-dependent diffusivity of the form D(x) = D-0|x|(alpha). Such processes yield anomalous diffusion and weak ergodicity breaking, the asymptotic disparity between ensemble and time averaged observables, such as the mean-squared displacement. Fractional Brownian motion (FBM) with its long-range correlated yet Gaussian increments gives rise to anomalous and ergodic diffusion. Here, we study a combined model of HDPs and FBM to describe the particle dynamics in complex systems with position-dependent diffusivity driven by fractional Gaussian noise. This type of motion is, inter alia, relevant for tracer-particle diffusion in biological cells or heterogeneous complex fluids. We show that the long-time scaling behavior predicted theoretically and by simulations for the ensemble-and time-averaged mean-squared displacements couple the scaling exponents alpha of HDPs and the Hurst exponent H of FBM in a characteristic way. Our analysis of the simulated data in terms of the rescaled variable y similar to |x|(1/(2/(2-alpha)))/t(H) coupling particle position x and time t yields a simple, Gaussian probability density function (PDF), PHDP-FBM(y) = e(-y2)/root pi. Its universal shape agrees well with theoretical predictions for both uni- and bimodal PDF distributions.}, language = {en} } @article{Bezzenberger2020, author = {Bezzenberger, Tilman}, title = {Anschauungsf{\"a}lle zur Unm{\"o}glichkeit der Leistung im gegenseitigen Vertrag}, series = {Jura : juristische Ausbildung}, volume = {42}, journal = {Jura : juristische Ausbildung}, number = {4}, publisher = {De Gruyter}, address = {Berlin}, issn = {0170-1452}, doi = {10.1515/jura-2019-2350}, pages = {378 -- 383}, year = {2020}, abstract = {Die folgenden Fallstudien wollen Standardwissen zu klassischen Themen des allgemeinen Schuldrechts in Erinnerung rufen und vor allem die Systematik der Falll{\"o}sung deutlich machen. Man darf sich nicht dazu verleiten lassen, alles auf einmal l{\"o}sen zu wollen, sondern muss auf die einzelnen Anspr{\"u}che blicken und sich fragen: (1) Was wird aus dem prim{\"a}ren Erf{\"u}llungsanspruch auf die gest{\"o}rte Leistung? (2) Gibt es Schadensersatzanspr{\"u}che, die als Sekund{\"a}ranspr{\"u}che an die Stelle des Prim{\"a}ranspruchs oder neben ihn treten? Und schließlich (3): Was ist mit dem Anspruch auf die Gegenleistung? Vom Schwierigkeitsgrad her ist das Folgende ungef{\"a}hr im Bereich einer gehobenen Zwischenpr{\"u}fungsklausur anzusiedeln.}, language = {de} } @article{LinkeWoesleHarder2020, author = {Linke, Christian and W{\"o}sle, Markus and Harder, Anja}, title = {Anti-cancer agent 3-bromopyruvate reduces growth of MPNST and inhibits metabolic pathways in a representative in-vitro model}, series = {BMC cancer}, volume = {20}, journal = {BMC cancer}, number = {1}, publisher = {BioMed Central}, address = {London}, issn = {1471-2407}, doi = {10.1186/s12885-020-07397-w}, pages = {11}, year = {2020}, abstract = {Background Anticancer compound 3-bromopyruvate (3-BrPA) suppresses cancer cell growth via targeting glycolytic and mitochondrial metabolism. The malignant peripheral nerve sheath tumor (MPNST), a very aggressive, therapy resistant, and Neurofibromatosis type 1 associated neoplasia, shows a high metabolic activity and affected patients may therefore benefit from 3-BrPA treatment. To elucidate the specific mode of action, we used a controlled cell model overexpressing proteasome activator (PA) 28, subsequently leading to p53 inactivation and oncogenic transformation and therefore reproducing an important pathway in MPNST and overall tumor pathogenesis. Methods Viability of MPNST cell lines S462, NSF1, and T265 in response to increasing doses (0-120 mu M) of 3-BrPA was analyzed by CellTiter-Blue (R) assay. Additionally, we investigated viability, reactive oxygen species (ROS) production (dihydroethidium assay), nicotinamide adenine dinucleotide dehydrogenase activity (NADH-TR assay) and lactate production (lactate assay) in mouse B8 fibroblasts overexpressing PA28 in response to 3-BrPA application. For all experiments normal and nutrient deficient conditions were tested. MPNST cell lines were furthermore characterized immunohistochemically for Ki67, p53, bcl2, bcl6, cyclin D1, and p21. Results MPNST significantly responded dose dependent to 3-BrPA application, whereby S462 cells were most responsive. Human control cells showed a reduced sensitivity. In PA28 overexpressing cancer cell model 3-BrPA application harmed mitochondrial NADH dehydrogenase activity mildly and significantly failed to inhibit lactate production. PA28 overexpression was associated with a functional glycolysis as well as a partial resistance to stress provoked by nutrient deprivation. 3-BrPA treatment was not associated with an increase of ROS. Starvation sensitized MPNST to treatment. Conclusions Aggressive MPNST cells are sensitive to 3-BrPA therapy in-vitro with and without starvation. In a PA28 overexpression cancer cell model leading to p53 inactivation, thereby reflecting a key molecular feature in human NF1 associated MPNST, known functions of 3-BrPA to block mitochondrial activity and glycolysis were reproduced, however oncogenic cells displayed a partial resistance. To conclude, 3-BrPA was sufficient to reduce NF1 associated MPNST viability potentially due inhibition of glycolysis which should lead to the initiation of further studies and promises a potential benefit for NF1 patients.}, language = {en} } @article{Holl2020, author = {Holl, Bernhard}, title = {Antij{\"u}dische Polemik unter falscher Flagge}, series = {Zeitschrift f{\"u}r Religions- und Geistesgeschichte}, volume = {72}, journal = {Zeitschrift f{\"u}r Religions- und Geistesgeschichte}, number = {4}, publisher = {Brill}, address = {Leiden}, issn = {0044-3441}, doi = {10.1163/15700739-07204004}, pages = {412 -- 424}, year = {2020}, abstract = {For the longest time historians have treated the infamous Libelo de Sevilla (1480) as an authentic document of the heresy of "Judaizing" allegedly wide spread among the so-called marrano or converso population. However, a closer look however reveals that the pamphlet is much more likely to be the fabrication of Old Christian agitators aiming to discredit both converts from Judaism and their allies.}, language = {de} } @article{ChepkiruiOchiengSarkaretal.2020, author = {Chepkirui, Carolyne and Ochieng, Purity J. and Sarkar, Biswajyoti and Hussain, Aabid and Pal, Chiranjib and Yang, Li Jun and Coghi, Paolo and Akala, Hoseah M. and Derese, Solomon and Ndakala, Albert and Heydenreich, Matthias and Wong, Vincent K. W. and Erdelyi, Mate and Yenesew, Abiy}, title = {Antiplasmodial and antileishmanial flavonoids from Mundulea sericea}, series = {Fitoterapia}, volume = {149}, journal = {Fitoterapia}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0367-326X}, doi = {10.1016/j.fitote.2020.104796}, pages = {6}, year = {2020}, abstract = {Five known compounds (1-5) were isolated from the extract of Mundulea sericea leaves. Similar investigation of the roots of this plant afforded an additional three known compounds (6-8). The structures were elucidated using NMR spectroscopic and mass spectrometric analyses. The absolute configuration of 1 was established using ECD spectroscopy. In an antiplasmodial activity assay, compound 1 showed good activity with an IC50 of 2.0 mu M against chloroquine-resistant W2, and 6.6 mu M against the chloroquine-sensitive 3D7 strains of Plasmodium falciparum. Some of the compounds were also tested for antileishmanial activity. Dehydrolupinifolinol (2) and sericetin (5) were active against drug-sensitive Leishmania donovani (MHOM/IN/83/AG83) with IC50 values of 9.0 and 5.0 mu M, respectively. In a cytotoxicity assay, lupinifolin (3) showed significant activity on BEAS-2B (IC50 4.9 mu M) and HePG2 (IC50 10.8 mu M) human cell lines. All the other compounds showed low cytotoxicity (IC50 > 30 mu M) against human lung adenocarcinoma cells (A549), human liver cancer cells (HepG2), lung/bronchus cells (epithelial virus transformed) (BEAS-2B) and immortal human hepatocytes (LO2)}, language = {en} } @article{AscheArnold2020, author = {Asche, Matthias and Arnold, Matthieu}, title = {Anton Schindling (1947-2020)}, series = {Francia : Forschungen zur westeurop{\"a}ischen Geschichte}, journal = {Francia : Forschungen zur westeurop{\"a}ischen Geschichte}, number = {47}, publisher = {Thorbecke}, address = {Ostfildern}, isbn = {978-3-7995-8147-9}, doi = {10.11588/fr.2020.0.75750}, pages = {501 -- 503}, year = {2020}, language = {de} } @article{Ette2020, author = {Ette, Ottmar}, title = {Anton Wilhelm Amo}, series = {Alexandria dein Magazin f{\"u}r Wissenschaft}, journal = {Alexandria dein Magazin f{\"u}r Wissenschaft}, number = {1}, publisher = {Verein f{\"u}r Wissenschaftskommunikation und zur F{\"o}rderung von Wissenschaftler_Innen}, address = {Wien}, pages = {17 -- 21}, year = {2020}, language = {de} }