@article{Baumgaertel2011, author = {Baumg{\"a}rtel, Hellmut}, title = {A Characteristic decay semigroup for the resonances of trace class perturbations with analyticity conditions of semibounded hamiltonians}, series = {International journal of theoretical physic}, volume = {50}, journal = {International journal of theoretical physic}, number = {7}, publisher = {Springer}, address = {New York}, issn = {0020-7748}, doi = {10.1007/s10773-010-0533-9}, pages = {2002 -- 2008}, year = {2011}, abstract = {To asymptotic complete scattering systems {M(+) + V, M(+)} on H(+) := L(2)(R(+), K, d lambda), where M(+) is the multiplication operator on H(+) and V is a trace class operator with analyticity conditions, a decay semigroup is associated such that the spectrum of the generator of this semigroup coincides with the set of all resonances (poles of the analytic continuation of the scattering matrix into the lower half plane across the positive half line), i.e. the decay semigroup yields a "time-dependent" characterization of the resonances. As a counterpart a "spectral characterization" is mentioned which is due to the "eigenvalue-like" properties of resonances.}, language = {en} } @article{CostaBronstertdeAraujo2012, author = {Costa, A. C. and Bronstert, Axel and de Araujo, Jose Carlos}, title = {A channel transmission losses model for different dryland rivers}, series = {Hydrology and earth system sciences : HESS}, volume = {16}, journal = {Hydrology and earth system sciences : HESS}, number = {4}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1027-5606}, doi = {10.5194/hess-16-1111-2012}, pages = {1111 -- 1135}, year = {2012}, abstract = {Channel transmission losses in drylands take place normally in extensive alluvial channels or streambeds underlain by fractured rocks. They can play an important role in streamflow rates, groundwater recharge, freshwater supply and channel-associated ecosystems. We aim to develop a process-oriented, semi-distributed channel transmission losses model, using process formulations which are suitable for data-scarce dryland environments and applicable to both hydraulically disconnected losing streams and hydraulically connected losing(/gaining) streams. This approach should be able to cover a large variation in climate and hydro-geologic controls, which are typically found in dryland regions of the Earth. Our model was first evaluated for a losing/gaining, hydraulically connected 30 km reach of the Middle Jaguaribe River (MJR), Ceara, Brazil, which drains a catchment area of 20 000 km(2). Secondly, we applied it to a small losing, hydraulically disconnected 1.5 km channel reach in the Walnut Gulch Experimental Watershed (WGEW), Arizona, USA. The model was able to predict reliably the streamflow volume and peak for both case studies without using any parameter calibration procedure. We have shown that the evaluation of the hypotheses on the dominant hydrological processes was fundamental for reducing structural model uncertainties and improving the streamflow prediction. For instance, in the case of the large river reach (MJR), it was shown that both lateral stream-aquifer water fluxes and groundwater flow in the underlying alluvium parallel to the river course are necessary to predict streamflow volume and channel transmission losses, the former process being more relevant than the latter. Regarding model uncertainty, it was shown that the approaches, which were applied for the unsaturated zone processes (highly nonlinear with elaborate numerical solutions), are much more sensitive to parameter variability than those approaches which were used for the saturated zone (mathematically simple water budgeting in aquifer columns, including backwater effects). In case of the MJR-application, we have seen that structural uncertainties due to the limited knowledge of the subsurface saturated system interactions (i.e. groundwater coupling with channel water; possible groundwater flow parallel to the river) were more relevant than those related to the subsurface parameter variability. In case of the WEGW application we have seen that the non-linearity involved in the unsaturated flow processes in disconnected dryland river systems (controlled by the unsaturated zone) generally contain far more model uncertainties than do connected systems controlled by the saturated flow. Therefore, the degree of aridity of a dryland river may be an indicator of potential model uncertainty and subsequent attainable predictability of the system.}, language = {en} } @article{MaslinTrauthChristensen2005, author = {Maslin, Mark and Trauth, Martin H. and Christensen, B.}, title = {A changing climate for human evolution}, issn = {0016-8556}, year = {2005}, language = {en} } @article{MontesHofnerOskinovaetal.2020, author = {Montes, Virginie A. and Hofner, Peter and Oskinova, Lida and Linz, Hendrik}, title = {A Chandra X-Ray and infrared study of the stellar population in the high-mass star-forming region IRAS 16562-3959}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, volume = {888}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, number = {2}, publisher = {Institute of Physics Publ.}, address = {London}, issn = {0004-637X}, doi = {10.3847/1538-4357/ab59cf}, pages = {15}, year = {2020}, abstract = {We present the results from Chandra X-ray observations, and near- and mid-infrared analysis, using VISTA/VVV and Spitzer/GLIMPSE catalogs, of the high-mass star-forming region IRAS 16562-3959, which contains a candidate for a high-mass protostar. We detected 249 X-ray sources within the ACIS-I field of view. The majority of the X-ray sources have low count rates (<0.638 cts/ks) and hard X-ray spectra. The search for YSOs in the region using VISTA/VVV and Spitzer/GLIMPSE catalogs resulted in a total of 636 YSOs, with 74 Class I and 562 Class II YSOs. The search for near- and mid-infrared counterparts of the X-ray sources led to a total of 165 VISTA/VVV counterparts, and a total of 151 Spitzer/GLIMPSE counterparts. The infrared analysis of the X-ray counterparts allowed us to identify an extra 91 Class III YSOs associated with the region. We conclude that a total of 727 YSOs are associated with the region, with 74 Class I, 562 Class II, and 91 Class III YSOs. We also found that the region is composed of 16 subclusters. In the vicinity of the high-mass protostar, the stellar distribution has a core-halo structure. The subcluster containing the high-mass protostar is the densest and the youngest in the region, and the high-mass protostar is located at its center. The YSOs in this cluster appear to be substantially older than the high-mass protostar.}, language = {en} } @article{HaueisStechKubick2022, author = {Haueis, Lisa and Stech, Marlitt and Kubick, Stefan}, title = {A Cell-free Expression Pipeline for the Generation and Functional Characterization of Nanobodies}, series = {Frontiers in Bioengineering and Biotechnology}, volume = {10}, journal = {Frontiers in Bioengineering and Biotechnology}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {2296-4185}, doi = {10.3389/fbioe.2022.896763}, pages = {11}, year = {2022}, abstract = {Cell-free systems are well-established platforms for the rapid synthesis, screening, engineering and modification of all kinds of recombinant proteins ranging from membrane proteins to soluble proteins, enzymes and even toxins. Also within the antibody field the cell-free technology has gained considerable attention with respect to the clinical research pipeline including antibody discovery and production. Besides the classical full-length monoclonal antibodies (mAbs), so-called "nanobodies" (Nbs) have come into focus. A Nb is the smallest naturally-derived functional antibody fragment known and represents the variable domain (VHH, similar to 15 kDa) of a camelid heavy-chain-only antibody (HCAb). Based on their nanoscale and their special structure, Nbs display striking advantages concerning their production, but also their characteristics as binders, such as high stability, diversity, improved tissue penetration and reaching of cavity-like epitopes. The classical way to produce Nbs depends on the use of living cells as production host. Though cell-based production is well-established, it is still time-consuming, laborious and hardly amenable for high-throughput applications. Here, we present for the first time to our knowledge the synthesis of functional Nbs in a standardized mammalian cell-free system based on Chinese hamster ovary (CHO) cell lysates. Cell-free reactions were shown to be time-efficient and easy-to-handle allowing for the "on demand" synthesis of Nbs. Taken together, we complement available methods and demonstrate a promising new system for Nb selection and validation.}, language = {en} } @article{LappeKallmeyer2011, author = {Lappe, Michael and Kallmeyer, Jens}, title = {A cell extraction method for oily sediments}, series = {Frontiers in microbiology}, volume = {2}, journal = {Frontiers in microbiology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-302X}, doi = {10.3389/fmicb.2011.00233}, pages = {11}, year = {2011}, abstract = {Hydrocarbons can be found in many different habitats and represent an important carbon source for microbes. As fossil fuels, they are also an important economical resource and through natural seepage or accidental release they can be major pollutants. DNA-specific stains and molecular probes bind to hydrocarbons, causing massive background fluorescence, thereby hampering cell enumeration. The cell extraction procedure of Kallmeyer et al. (2008) separates the cells from the sediment matrix. In principle, this technique can also be used to separate cells from oily sediments, but it was not originally optimized for this application. Here we present a modified extraction method in which the hydrocarbons are removed prior to cell extraction. Due to the reduced background fluorescence the microscopic image becomes clearer, making cell identification, and enumeration much easier. Consequently, the resulting cell counts from oily samples treated according to our new protocol are significantly higher than those treated according to Kallmeyer et al. (2008). We tested different amounts of a variety of solvents for their ability to remove hydrocarbons and found that n-hexane and in samples containing more mature oils methanol, delivered the best results. However, as solvents also tend to lyse cells, it was important to find the optimum solvent to sample ratio, at which hydrocarbon extraction is maximized and cell lysis minimized. A volumetric ratio of 1:2-1:5 between a formalin-fixed sediment slurry and solvent delivered highest cell counts. Extraction efficiency was around 30-50\% and was checked on both oily samples spiked with known amounts of E. coli cells and oil-free samples amended with fresh and biodegraded oil. The method provided reproducible results on samples containing very different kinds of oils with regard to their degree of biodegradation. For strongly biodegraded oil MeOH turned out to be the most appropriate solvent, whereas for less biodegraded samples n-hexane delivered best results.}, language = {en} } @article{Ly2020, author = {Ly, Ibrahim}, title = {A Cauchy problem for the Cauchy-Riemann operator}, series = {Afrika Matematika}, volume = {32}, journal = {Afrika Matematika}, number = {1-2}, publisher = {Springer}, address = {Heidelberg}, issn = {1012-9405}, doi = {10.1007/s13370-020-00810-4}, pages = {69 -- 76}, year = {2020}, abstract = {We study the Cauchy problem for a nonlinear elliptic equation with data on a piece S of the boundary surface partial derivative X. By the Cauchy problem is meant any boundary value problem for an unknown function u in a domain X with the property that the data on S, if combined with the differential equations in X, allows one to determine all derivatives of u on S by means of functional equations. In the case of real analytic data of the Cauchy problem, the existence of a local solution near S is guaranteed by the Cauchy-Kovalevskaya theorem. We discuss a variational setting of the Cauchy problem which always possesses a generalized solution.}, language = {en} } @article{WuttkeLiLietal.2019, author = {Wuttke, Matthias and Li, Yong and Li, Man and Sieber, Karsten B. and Feitosa, Mary F. and Gorski, Mathias and Tin, Adrienne and Wang, Lihua and Chu, Audrey Y. and Hoppmann, Anselm and Kirsten, Holger and Giri, Ayush and Chai, Jin-Fang and Sveinbjornsson, Gardar and Tayo, Bamidele O. and Nutile, Teresa and Fuchsberger, Christian and Marten, Jonathan and Cocca, Massimiliano and Ghasemi, Sahar and Xu, Yizhe and Horn, Katrin and Noce, Damia and Van der Most, Peter J. and Sedaghat, Sanaz and Yu, Zhi and Akiyama, Masato and Afaq, Saima and Ahluwalia, Tarunveer Singh and Almgren, Peter and Amin, Najaf and Arnlov, Johan and Bakker, Stephan J. L. and Bansal, Nisha and Baptista, Daniela and Bergmann, Sven and Biggs, Mary L. and Biino, Ginevra and Boehnke, Michael and Boerwinkle, Eric and Boissel, Mathilde and B{\"o}ttinger, Erwin and Boutin, Thibaud S. and Brenner, Hermann and Brumat, Marco and Burkhardt, Ralph and Butterworth, Adam S. and Campana, Eric and Campbell, Archie and Campbell, Harry and Canouil, Mickael and Carroll, Robert J. and Catamo, Eulalia and Chambers, John C. and Chee, Miao-Ling and Chee, Miao-Li and Chen, Xu and Cheng, Ching-Yu and Cheng, Yurong and Christensen, Kaare and Cifkova, Renata and Ciullo, Marina and Concas, Maria Pina and Cook, James P. and Coresh, Josef and Corre, Tanguy and Sala, Cinzia Felicita and Cusi, Daniele and Danesh, John and Daw, E. Warwick and De Borst, Martin H. and De Grandi, Alessandro and De Mutsert, Renee and De Vries, Aiko P. J. and Degenhardt, Frauke and Delgado, Graciela and Demirkan, Ayse and Di Angelantonio, Emanuele and Dittrich, Katalin and Divers, Jasmin and Dorajoo, Rajkumar and Eckardt, Kai-Uwe and Ehret, Georg and Elliott, Paul and Endlich, Karlhans and Evans, Michele K. and Felix, Janine F. and Foo, Valencia Hui Xian and Franco, Oscar H. and Franke, Andre and Freedman, Barry I. and Freitag-Wolf, Sandra and Friedlander, Yechiel and Froguel, Philippe and Gansevoort, Ron T. and Gao, He and Gasparini, Paolo and Gaziano, J. Michael and Giedraitis, Vilmantas and Gieger, Christian and Girotto, Giorgia and Giulianini, Franco and Gogele, Martin and Gordon, Scott D. and Gudbjartsson, Daniel F. and Gudnason, Vilmundur and Haller, Toomas and Hamet, Pavel and Harris, Tamara B. and Hartman, Catharina A. and Hayward, Caroline and Hellwege, Jacklyn N. and Heng, Chew-Kiat and Hicks, Andrew A. and Hofer, Edith and Huang, Wei and Hutri-Kahonen, Nina and Hwang, Shih-Jen and Ikram, M. Arfan and Indridason, Olafur S. and Ingelsson, Erik and Ising, Marcus and Jaddoe, Vincent W. V. and Jakobsdottir, Johanna and Jonas, Jost B. and Joshi, Peter K. and Josyula, Navya Shilpa and Jung, Bettina and Kahonen, Mika and Kamatani, Yoichiro and Kammerer, Candace M. and Kanai, Masahiro and Kastarinen, Mika and Kerr, Shona M. and Khor, Chiea-Chuen and Kiess, Wieland and Kleber, Marcus E. and Koenig, Wolfgang and Kooner, Jaspal S. and Korner, Antje and Kovacs, Peter and Kraja, Aldi T. and Krajcoviechova, Alena and Kramer, Holly and Kramer, Bernhard K. and Kronenberg, Florian and Kubo, Michiaki and Kuhnel, Brigitte and Kuokkanen, Mikko and Kuusisto, Johanna and La Bianca, Martina and Laakso, Markku and Lange, Leslie A. and Langefeld, Carl D. and Lee, Jeannette Jen-Mai and Lehne, Benjamin and Lehtimaki, Terho and Lieb, Wolfgang and Lim, Su-Chi and Lind, Lars and Lindgren, Cecilia M. and Liu, Jun and Liu, Jianjun and Loeffler, Markus and Loos, Ruth J. F. and Lucae, Susanne and Lukas, Mary Ann and Lyytikainen, Leo-Pekka and Magi, Reedik and Magnusson, Patrik K. E. and Mahajan, Anubha and Martin, Nicholas G. and Martins, Jade and Marz, Winfried and Mascalzoni, Deborah and Matsuda, Koichi and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Metspalu, Andres and Mikaelsdottir, Evgenia K. and Milaneschi, Yuri and Miliku, Kozeta and Mishra, Pashupati P. and Program, V. A. Million Veteran and Mohlke, Karen L. and Mononen, Nina and Montgomery, Grant W. and Mook-Kanamori, Dennis O. and Mychaleckyj, Josyf C. and Nadkarni, Girish N. and Nalls, Mike A. and Nauck, Matthias and Nikus, Kjell and Ning, Boting and Nolte, Ilja M. and Noordam, Raymond and Olafsson, Isleifur and Oldehinkel, Albertine J. and Orho-Melander, Marju and Ouwehand, Willem H. and Padmanabhan, Sandosh and Palmer, Nicholette D. and Palsson, Runolfur and Penninx, Brenda W. J. H. and Perls, Thomas and Perola, Markus and Pirastu, Mario and Pirastu, Nicola and Pistis, Giorgio and Podgornaia, Anna I. and Polasek, Ozren and Ponte, Belen and Porteous, David J. and Poulain, Tanja and Pramstaller, Peter P. and Preuss, Michael H. and Prins, Bram P. and Province, Michael A. and Rabelink, Ton J. and Raffield, Laura M. and Raitakari, Olli T. and Reilly, Dermot F. and Rettig, Rainer and Rheinberger, Myriam and Rice, Kenneth M. and Ridker, Paul M. and Rivadeneira, Fernando and Rizzi, Federica and Roberts, David J. and Robino, Antonietta and Rossing, Peter and Rudan, Igor and Rueedi, Rico and Ruggiero, Daniela and Ryan, Kathleen A. and Saba, Yasaman and Sabanayagam, Charumathi and Salomaa, Veikko and Salvi, Erika and Saum, Kai-Uwe and Schmidt, Helena and Schmidt, Reinhold and Ben Schottker, and Schulz, Christina-Alexandra and Schupf, Nicole and Shaffer, Christian M. and Shi, Yuan and Smith, Albert V. and Smith, Blair H. and Soranzo, Nicole and Spracklen, Cassandra N. and Strauch, Konstantin and Stringham, Heather M. and Stumvoll, Michael and Svensson, Per O. and Szymczak, Silke and Tai, E-Shyong and Tajuddin, Salman M. and Tan, Nicholas Y. Q. and Taylor, Kent D. and Teren, Andrej and Tham, Yih-Chung and Thiery, Joachim and Thio, Chris H. L. and Thomsen, Hauke and Thorleifsson, Gudmar and Toniolo, Daniela and Tonjes, Anke and Tremblay, Johanne and Tzoulaki, Ioanna and Uitterlinden, Andre G. and Vaccargiu, Simona and Van Dam, Rob M. and Van der Harst, Pim and Van Duijn, Cornelia M. and Edward, Digna R. Velez and Verweij, Niek and Vogelezang, Suzanne and Volker, Uwe and Vollenweider, Peter and Waeber, Gerard and Waldenberger, Melanie and Wallentin, Lars and Wang, Ya Xing and Wang, Chaolong and Waterworth, Dawn M. and Bin Wei, Wen and White, Harvey and Whitfield, John B. and Wild, Sarah H. and Wilson, James F. and Wojczynski, Mary K. and Wong, Charlene and Wong, Tien-Yin and Xu, Liang and Yang, Qiong and Yasuda, Masayuki and Yerges-Armstrong, Laura M. and Zhang, Weihua and Zonderman, Alan B. and Rotter, Jerome I. and Bochud, Murielle and Psaty, Bruce M. and Vitart, Veronique and Wilson, James G. and Dehghan, Abbas and Parsa, Afshin and Chasman, Daniel I. and Ho, Kevin and Morris, Andrew P. and Devuyst, Olivier and Akilesh, Shreeram and Pendergrass, Sarah A. and Sim, Xueling and Boger, Carsten A. and Okada, Yukinori and Edwards, Todd L. and Snieder, Harold and Stefansson, Kari and Hung, Adriana M. and Heid, Iris M. and Scholz, Markus and Teumer, Alexander and Kottgen, Anna and Pattaro, Cristian}, title = {A catalog of genetic loci associated with kidney function from analyses of a million individuals}, series = {Nature genetics}, volume = {51}, journal = {Nature genetics}, number = {6}, publisher = {Nature Publ. Group}, address = {New York}, organization = {Lifelines COHort Study}, issn = {1061-4036}, doi = {10.1038/s41588-019-0407-x}, pages = {957 -- +}, year = {2019}, abstract = {Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.}, language = {en} } @article{SchwarzDeBleserPoecketal.1998, author = {Schwarz, M. R. and De Bleser, Ria and Poeck, K. and Weis, J.}, title = {A case of primary progressive ahasia : a 14year follow-up study with neuropathological findings}, year = {1998}, language = {en} } @article{Mayar2017, author = {Mayar, Mahshid}, title = {A Case for Serious Play}, series = {Milit{\"a}r und Gesellschaft in der fr{\"u}hen Neuzeit}, volume = {20}, journal = {Milit{\"a}r und Gesellschaft in der fr{\"u}hen Neuzeit}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-9722}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-408309}, pages = {117 -- 135}, year = {2017}, language = {en} } @article{BergMohnickeNendel2022, author = {Berg-Mohnicke, Michael and Nendel, Claas}, title = {A case for object capabilities as the foundation of a distributed environmental model and simulation infrastructure}, series = {Environmental modelling \& software with environment data news}, volume = {156}, journal = {Environmental modelling \& software with environment data news}, publisher = {Elsevier}, address = {Oxford}, issn = {1364-8152}, doi = {10.1016/j.envsoft.2022.105471}, pages = {12}, year = {2022}, abstract = {With the advent of increasingly powerful computational architectures, scientists use these possibilities to create simulations of ever-increasing size and complexity. Large-scale simulations of environmental systems require huge amounts of resources. Managing these in an operational way becomes increasingly complex and difficult to handle for individual scientists. State-of-the-art simulation infrastructures usually provide the necessary re-sources in a centralised setup, which often results in an all-or-nothing choice for the user. Here, we outline an alternative approach to handling this complexity, while rendering the use of high-performance hardware and large datasets still possible. It retains a number of desirable properties: (i) a decentralised structure, (ii) easy sharing of resources to promote collaboration and (iii) secure access to everything, including natural delegation of authority across levels and system boundaries. We show that the object capability paradigm will cover these issues, and present the first steps towards developing a simulation infrastructure based on these principles.}, language = {en} } @article{SalffnerBoehmReichetal.2014, author = {Salffner, Katharina and Boehm, Michael and Reich, Oliver and L{\"o}hmannsr{\"o}ben, Hans-Gerd}, title = {A broadband cavity ring-down spectrometer based on an incoherent near infrared light source}, series = {Applied physics : B, Lasers and optics}, volume = {116}, journal = {Applied physics : B, Lasers and optics}, number = {4}, publisher = {Springer}, address = {New York}, issn = {0946-2171}, doi = {10.1007/s00340-014-5762-9}, pages = {785 -- 792}, year = {2014}, language = {en} } @article{RamiaramanantsoaRatnasingamShenaretal.2018, author = {Ramiaramanantsoa, Tahina and Ratnasingam, Rathish and Shenar, Tomer and Moffat, Anthony F. J. and Rogers, Tamara M. and Popowicz, Adam and Kuschnig, Rainer and Pigulski, Andrzej and Handler, Gerald and Wade, Gregg A. and Zwintz, Konstanze and Weiss, Werner W.}, title = {A BRITE view on the massive O-type supergiant V973 Scorpii}, series = {Monthly notices of the Royal Astronomical Society}, volume = {480}, journal = {Monthly notices of the Royal Astronomical Society}, number = {1}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0035-8711}, doi = {10.1093/mnras/sty1897}, pages = {972 -- 986}, year = {2018}, abstract = {Stochastically triggered photospheric light variations reaching similar to 40 mmag peak-to-valley amplitudes have been detected in the O8 Iaf supergiant V973 Scorpii as the outcome of 2 months of high-precision time-resolved photometric observations with the BRIght Target Explorer (BRITE) nanosatellites. The amplitude spectrum of the time series photometry exhibits a pronounced broad bump in the low-frequency regime (less than or similar to 0.9 d(-1)) where several prominent frequencies are detected. A time-frequency analysis of the observations reveals typical mode lifetimes of the order of 5-10 d. The overall features of the observed brightness amplitude spectrum of V973 Sco match well with those extrapolated from two-dimensional hydrodynamical simulations of convectively driven internal gravity waves randomly excited from deep in the convective cores of massive stars. An alternative or additional possible source of excitation from a sub-surface convection zone needs to be explored in future theoretical investigations.}, language = {en} } @article{ChristakoudiTsilidisMulleretal.2020, author = {Christakoudi, Sofa and Tsilidis, Konstantinos K. and Muller, David C. and Freisling, Heinz and Weiderpass, Elisabete and Overvad, Kim and S{\"o}derberg, Stefan and H{\"a}ggstr{\"o}m, Christel and Pischon, Tobias and Dahm, Christina C. and Zhang, Jie and Tj{\o}nneland, Anne and Schulze, Matthias Bernd}, title = {A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort}, series = {Scientific Reports}, volume = {10}, journal = {Scientific Reports}, number = {1}, publisher = {Springer Nature}, address = {Berlin}, pages = {15}, year = {2020}, abstract = {Abdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices to complement body mass index (BMI) when assessing all-cause mortality. We used data from 352,985 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) and Cox proportional hazards models adjusted for other risk factors. During a mean follow-up of 16.1 years, 38,178 participants died. Combining in one model BMI and a strongly correlated waist index altered the association patterns with mortality, to a predominantly negative association for BMI and a stronger positive association for the waist index, while combining BMI with the uncorrelated A Body Shape Index (ABSI) preserved the association patterns. Sex-specific cohort-wide quartiles of waist indices correlated with BMI could not separate high-risk from low-risk individuals within underweight (BMI<18.5 kg/m(2)) or obese (BMI30 kg/m(2)) categories, while the highest quartile of ABSI separated 18-39\% of the individuals within each BMI category, which had 22-55\% higher risk of death. In conclusion, only a waist index independent of BMI by design, such as ABSI, complements BMI and enables efficient risk stratification, which could facilitate personalisation of screening, treatment and monitoring.}, language = {en} } @article{Scianna2018, author = {Scianna, Bastian Matteo}, title = {A Blueprint for Successful Peacekeeping?}, series = {The international history review}, volume = {41}, journal = {The international history review}, number = {3}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0707-5332}, doi = {10.1080/07075332.2018.1431804}, pages = {650 -- 672}, year = {2018}, abstract = {On 6 June 1982, Israel invaded Lebanon to fight the Palestinian Liberation Organization (PLO). Between August 1982 and February 1984, the US, France, Britain and Italy deployed a Multinational Force (MNF) to Beirut. Its task was to act as an interposition force to bolster the government and to bring peace to the people. The mission is often forgotten or merely remembered in context with the bombing of US Marines' barracks. However, an analysis of the Italian contingent shows that the MNF was not doomed to fail and could accomplish its task when operational and diplomatic efforts were coordinated. The Italian commander in Beirut, General Franco Angioni, followed a successful approach that sustained neutrality, respectful behaviour and minimal force, which resulted in a qualified success of the Italian efforts.}, language = {en} } @article{Hoehnke1996, author = {Hoehnke, Hans-J{\"u}rgen}, title = {A Birkhoff theorem for partial algebras via completion}, year = {1996}, language = {en} } @article{OmidbakhshfardNeerakkalGuptaetal.2020, author = {Omidbakhshfard, Mohammad Amin and Neerakkal, Sujeeth and Gupta, Saurabh and Omranian, Nooshin and Guinan, Kieran J. and Brotman, Yariv and Nikoloski, Zoran and Fernie, Alisdair R. and Mueller-Roeber, Bernd and Gechev, Tsanko S.}, title = {A Biostimulant Obtained from the Seaweed Ascophyllum nodosum Protects Arabidopsis thaliana from Severe Oxidative Stress}, series = {International Journal of Molecular Sciences}, volume = {21}, journal = {International Journal of Molecular Sciences}, number = {2}, publisher = {Molecular Diversity Preservation International}, address = {Basel}, issn = {1422-0067}, doi = {10.3390/ijms21020474}, pages = {26}, year = {2020}, abstract = {Abiotic stresses cause oxidative damage in plants. Here, we demonstrate that foliar application of an extract from the seaweed Ascophyllum nodosum, SuperFifty (SF), largely prevents paraquat (PQ)-induced oxidative stress in Arabidopsis thaliana. While PQ-stressed plants develop necrotic lesions, plants pre-treated with SF (i.e., primed plants) were unaffected by PQ. Transcriptome analysis revealed induction of reactive oxygen species (ROS) marker genes, genes involved in ROS-induced programmed cell death, and autophagy-related genes after PQ treatment. These changes did not occur in PQ-stressed plants primed with SF. In contrast, upregulation of several carbohydrate metabolism genes, growth, and hormone signaling as well as antioxidant-related genes were specific to SF-primed plants. Metabolomic analyses revealed accumulation of the stress-protective metabolite maltose and the tricarboxylic acid cycle intermediates fumarate and malate in SF-primed plants. Lipidome analysis indicated that those lipids associated with oxidative stress-induced cell death and chloroplast degradation, such as triacylglycerols (TAGs), declined upon SF priming. Our study demonstrated that SF confers tolerance to PQ-induced oxidative stress in A. thaliana, an effect achieved by modulating a range of processes at the transcriptomic, metabolic, and lipid levels.}, language = {en} } @article{BadalyanNeumannSchaalLeimkuehleretal.2013, author = {Badalyan, Artavazd and Neumann-Schaal, Meina and Leimk{\"u}hler, Silke and Wollenberger, Ursula}, title = {A Biosensor for aromatic aldehydes comprising the mediator dependent PaoABC-Aldehyde oxidoreductase}, series = {Electroanalysis : an international journal devoted to fundamental and practical aspects of electroanalysis}, volume = {25}, journal = {Electroanalysis : an international journal devoted to fundamental and practical aspects of electroanalysis}, number = {1}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1040-0397}, doi = {10.1002/elan.201200362}, pages = {101 -- 108}, year = {2013}, abstract = {A novel aldehyde oxidoreductase (PaoABC) from Escherichia coli was utilized for the development of an oxygen insensitive biosensor for benzaldehyde. The enzyme was immobilized in polyvinyl alcohol and currents were measured for aldehyde oxidation with different one and two electron mediators with the highest sensitivity for benzaldehyde in the presence of hexacyanoferrate(III). The benzaldehyde biosensor was optimized with respect to mediator concentration, enzyme loading and pH using potassium hexacyanoferrate(III). The linear measuring range is between 0.5200 mu M benzaldehyde. In correspondence with the substrate selectivity of the enzyme in solution the biosensor revealed a preference for aromatic aldehydes and less effective conversion of aliphatic aldehydes. The biosensor is oxygen independent, which is a particularly attractive feature for application. The biosensor can be applied to detect contaminations with benzaldehyde in solvents such as benzyl alcohol, where traces of benzaldehyde in benzyl alcohol down to 0.0042?\% can be detected.}, language = {en} } @article{FelisattiLaubrockShakietal.2020, author = {Felisatti, Arianna and Laubrock, Jochen and Shaki, Samuel and Fischer, Martin H.}, title = {A biological foundation for spatial-numerical associations}, series = {Annals of the New York Academy of Sciences}, volume = {1477}, journal = {Annals of the New York Academy of Sciences}, number = {1}, publisher = {Wiley}, address = {Hoboken}, issn = {0077-8923}, doi = {10.1111/nyas.14418}, pages = {44 -- 53}, year = {2020}, abstract = {"Left" and "right" coordinates control our spatial behavior and even influence abstract thoughts. For number concepts, horizontal spatial-numerical associations (SNAs) have been widely documented: we associate few with left and many with right. Importantly, increments are universally coded on the right side even in preverbal humans and nonhuman animals, thus questioning the fundamental role of directional cultural habits, such as reading or finger counting. Here, we propose a biological, nonnumerical mechanism for the origin of SNAs on the basis of asymmetric tuning of animal brains for different spatial frequencies (SFs). The resulting selective visual processing predicts both universal SNAs and their context-dependence. We support our proposal by analyzing the stimuli used to document SNAs in newborns for their SF content. As predicted, the SFs contained in visual patterns with few versus many elements preferentially engage right versus left brain hemispheres, respectively, thus predicting left-versus rightward behavioral biases. Our "brain's asymmetric frequency tuning" hypothesis explains the perceptual origin of horizontal SNAs for nonsymbolic visual numerosities and might be extensible to the auditory domain.}, language = {en} } @article{BoechatWeithoffKruegeretal.2007, author = {Bo{\"e}chat, Iola G. and Weithoff, Guntram and Kr{\"u}ger, Angela and G{\"u}cker, Bj{\"o}rn and Adrian, Rita}, title = {A biochemical explanation for the success of the mixotrophy in the flagellate Ochromonas sp.}, issn = {0024-3590}, doi = {10.4319/lo.2007.52.4.1624}, year = {2007}, abstract = {We report the influence of different nutritional modes-autotrophy, mixotrophy, and heterotrophy-on the fatty acid and sterol composition of the freshwater flagellate Ochromonas sp. and discuss the ecological significance of our results with respect to the resource competition theory (rct). Polyunsaturated fatty acids (PUFAs) are the most efficient biochemical variable distinguishing between nutritional modes of Ochromonas sp. Decreasing concentrations of PUFAs were observed in the order autotrophs, mixotrophs, heterotrophs. In mixotrophs and heterotrophs, concentrations of saturated fatty acids were higher than those of monounsaturated fatty acids and PUFAs as a result of bacterivory. Stigmasterol was the main sterol in Ochromonas sp., regardless of nutritional mode. Mixotrophs showed higher growth rates than heterotrophs, which could not be explained by rct. Heterotrophs, in turn, exhibited higher growth rates than autotrophs, which were cultured under the same light conditions as mixotrophs. Mixotrophs can synthesize PUFAs, which are important for many physiological functions such as membrane permeability and growth. Thus, mixotrophy facilitated efficient growth as well as the ability to synthesize complex and essential biomolecules. These strong synergetic effects are due to the combination of biochemical benefits of heterotrophic and autotrophic metabolic pathways and cannot be predicted by rct.}, language = {en} } @article{ZhangBramskiTutusetal.2019, author = {Zhang, Shuhao and Bramski, Julia and Tutus, Murat and Pietruszka, J{\"o}rg and B{\"o}ker, Alexander and Reinicke, Stefan}, title = {A Biocatalytically Active Membrane Obtained from Immobilization of 2-Deoxy-D-ribose-5-phosphate Aldolase on a Porous Support}, series = {ACS applied materials \& interfaces}, volume = {11}, journal = {ACS applied materials \& interfaces}, number = {37}, publisher = {American Chemical Society}, address = {Washington}, issn = {1944-8244}, doi = {10.1021/acsami.9b12029}, pages = {34441 -- 34453}, year = {2019}, abstract = {Aldol reactions play an important role in organic synthesis, as they belong to the class of highly beneficial C-C-linking reactions. Aldol-type reactions can be efficiently and stereoselectively catalyzed by the enzyme 2-deoxy-D-ribose-5-phosphate aldolase (DERA) to gain key intermediates for pharmaceuticals such as atorvastatin. The immobilization of DERA would open the opportunity for a continuous operation mode which gives access to an efficient, large-scale production of respective organic intermediates. In this contribution, we synthesize and utilize DERA/polymer conjugates for the generation and fixation of a DERA bearing thin film on a polymeric membrane support. The conjugation strongly increases the tolerance of the enzyme toward the industrial relevant substrate acetaldehyde while UV-cross-linkable groups along the conjugated polymer chains provide the opportunity for covalent binding to the support. First, we provide a thorough characterization of the conjugates followed by immobilization tests on representative, nonporous cycloolefinic copolymer supports. Finally, immobilization on the target supports constituted of polyacrylonitrile (PAN) membranes is performed, and the resulting enzymatically active membranes are implemented in a simple membrane module setup for the first assessment of biocatalytic performance in the continuous operation mode using the combination hexanal/acetaldehyde as the substrate.}, language = {en} } @article{LettauWarsinkeKatterleetal.2006, author = {Lettau, Kristian and Warsinke, Axel and Katterle, Martin and Danielsson, Bengt and Scheller, Frieder W.}, title = {A bifunctional molecularly imprinted polymer (MIP): analysis of binding and catalysis by a thermistor}, doi = {10.1002/anie.200601796}, year = {2006}, abstract = {Binding or catalysis? Both can be distinguished with a molecularly imprinted polymer (MIP) by the different patterns of heat generation. The catalytically active sites, like in the corresponding enzyme, generate a steady-state temperature increase. Thus, enzyme-like catalysis and antibody-analogue binding are analyzed simultaneously in a bifunctional MIP for the first time (see scheme).}, language = {en} } @article{EremenkoMakowerBaueretal.1997, author = {Eremenko, A. V. and Makower, Alexander and Bauer, Christian G. and Kurochkin, I. N. and Scheller, Frieder W.}, title = {A bienzyme electrode for tyrosine containing peptides determination}, year = {1997}, language = {en} } @article{GajovicWarsinkeScheller1998, author = {Gajovic, Nenad and Warsinke, Axel and Scheller, Frieder W.}, title = {A bienzyme electrode for L-malate based on a novel and general design}, year = {1998}, language = {en} } @article{HuangWarsinkeKoroljovaSkorobogatkoetal.1999, author = {Huang, T. and Warsinke, Axel and Koroljova-Skorobogatko, O. V. and Makower, Alexander and Kuwana, T. and Scheller, Frieder W.}, title = {A bienzyme carbon paste electrode for the sensitive detection of NADPH and the measurement of glucose-6- phosphate dehydrogenase}, year = {1999}, language = {en} } @article{JannJantz2008, author = {Jann, Werner and Jantz, Bastian}, title = {A better performance and performance management?}, year = {2008}, language = {en} } @article{KlauschiesCoutinhoGaedke2018, author = {Klauschies, Toni and Coutinho, Renato Mendes and Gaedke, Ursula}, title = {A beta distribution-based moment closure enhances the reliability of trait-based aggregate models for natural populations and communities}, series = {Ecological modelling : international journal on ecological modelling and engineering and systems ecolog}, volume = {381}, journal = {Ecological modelling : international journal on ecological modelling and engineering and systems ecolog}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0304-3800}, doi = {10.1016/j.ecolmodel.2018.02.001}, pages = {46 -- 77}, year = {2018}, abstract = {Ecological communities are complex adaptive systems that exhibit remarkable feedbacks between their biomass and trait dynamics. Trait-based aggregate models cope with this complexity by focusing on the temporal development of the community's aggregate properties such as its total biomass, mean trait and trait variance. They are based on particular assumptions about the shape of the underlying trait distribution, which is commonly assumed to be normal. However, ecologically important traits are usually restricted to a finite range, and empirical trait distributions are often skewed or multimodal. As a result, normal distribution-based aggregate models may fail to adequately represent the biomass and trait dynamics of natural communities. We resolve this mismatch by developing a new moment closure approach assuming the trait values to be beta-distributed. We show that the beta distribution captures important shape properties of both observed and simulated trait distributions, which cannot be captured by a Gaussian. We further demonstrate that a beta distribution-based moment closure can strongly enhance the reliability of trait-based aggregate models. We compare the biomass, mean trait and variance dynamics of a full trait distribution (FD) model to the ones of beta (BA) and normal (NA) distribution-based aggregate models, under different selection regimes. This way, we demonstrate under which general conditions (stabilizing, fluctuating or disruptive selection) different aggregate models are reliable tools. All three models predicted very similar biomass and trait dynamics under stabilizing selection yielding unimodal trait distributions with small standing trait variation. We also obtained an almost perfect match between the results of the FD and BA models under fluctuating selection, promoting skewed trait distributions and ongoing oscillations in the biomass and trait dynamics. In contrast, the NA model showed unrealistic trait dynamics and exhibited different alternative stable states, and thus a high sensitivity to initial conditions under fluctuating selection. Under disruptive selection, both aggregate models failed to reproduce the results of the FD model with the mean trait values remaining within their ecologically feasible ranges in the BA model but not in the NA model. Overall, a beta distribution-based moment closure strongly improved the realism of trait-based aggregate models.}, language = {en} } @article{WolffZhangHaagenDeckeretal.2017, author = {Wolff, Martin and Zhang-Haagen, Bo and Decker, Christina and Barz, Bogdan and Schneider, Mario and Biehl, Ralf and Radulescu, Aurel and Strodel, Birgit and Willbold, Dieter and Nagel-Steger, Luitgard}, title = {A beta 42 pentamers/hexamers are the smallest detectable oligomers in solution}, series = {Scientific reports}, volume = {7}, journal = {Scientific reports}, publisher = {Nature Publ. Group}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-017-02370-3}, pages = {13}, year = {2017}, language = {en} } @article{GschwindKressigLacroixetal.2013, author = {Gschwind, Yves J. and Kressig, Reto W. and Lacroix, Andre and M{\"u}hlbauer, Thomas and Pfenninger, Barbara and Granacher, Urs}, title = {A best practice fall prevention exercise program to improve balance, strength/power, and psychosocial health in older adults - study protocol for a randomized controlled trial}, series = {BMC geriatrics}, volume = {13}, journal = {BMC geriatrics}, number = {4}, publisher = {BioMed Central}, address = {London}, issn = {1471-2318}, doi = {10.1186/1471-2318-13-105}, pages = {13}, year = {2013}, abstract = {Background: With increasing age neuromuscular deficits (e.g., sarcopenia) may result in impaired physical performance and an increased risk for falls. Prominent intrinsic fall-risk factors are age-related decreases in balance and strength / power performance as well as cognitive decline. Additional studies are needed to develop specifically tailored exercise programs for older adults that can easily be implemented into clinical practice. Thus, the objective of the present trial is to assess the effects of a fall prevention program that was developed by an interdisciplinary expert panel on measures of balance, strength / power, body composition, cognition, psychosocial well-being, and falls self-efficacy in healthy older adults. Additionally, the time-related effects of detraining are tested. Methods/Design: Healthy old people (n = 54) between the age of 65 to 80 years will participate in this trial. The testing protocol comprises tests for the assessment of static / dynamic steady-state balance (i.e., Sharpened Romberg Test, instrumented gait analysis), proactive balance (i.e., Functional Reach Test; Timed Up and Go Test), reactive balance (i.e., perturbation test during bipedal stance; Push and Release Test), strength (i.e., hand grip strength test; Chair Stand Test), and power (i.e., Stair Climb Power Test; countermovement jump). Further, body composition will be analysed using a bioelectrical impedance analysis system. In addition, questionnaires for the assessment of psychosocial (i.e., World Health Organisation Quality of Life Assessment-Bref), cognitive (i.e., Mini Mental State Examination), and fall risk determinants (i.e., Fall Efficacy Scale -International) will be included in the study protocol. Participants will be randomized into two intervention groups or the control / waiting group. After baseline measures, participants in the intervention groups will conduct a 12-week balance and strength / power exercise intervention 3 times per week, with each training session lasting 30 min. (actual training time). One intervention group will complete an extensive supervised training program, while the other intervention group will complete a short version (` 3 times 3') that is home-based and controlled by weekly phone calls. Post-tests will be conducted right after the intervention period. Additionally, detraining effects will be measured 12 weeks after program cessation. The control group / waiting group will not participate in any specific intervention during the experimental period, but will receive the extensive supervised program after the experimental period. Discussion: It is expected that particularly the supervised combination of balance and strength / power training will improve performance in variables of balance, strength / power, body composition, cognitive function, psychosocial well-being, and falls self-efficacy of older adults. In addition, information regarding fall risk assessment, dose-response-relations, detraining effects, and supervision of training will be provided. Further, training-induced health-relevant changes, such as improved performance in activities of daily living, cognitive function, and quality of life, as well as a reduced risk for falls may help to lower costs in the health care system. Finally, practitioners, therapists, and instructors will be provided with a scientifically evaluated feasible, safe, and easy-to-administer exercise program for fall prevention.}, language = {en} } @article{MariucciRaySzabo2020, author = {Mariucci, Ester and Ray, Kolyan and Szabo, Botond}, title = {A Bayesian nonparametric approach to log-concave density estimation}, series = {Bernoulli : official journal of the Bernoulli Society for Mathematical Statistics and Probability}, volume = {26}, journal = {Bernoulli : official journal of the Bernoulli Society for Mathematical Statistics and Probability}, number = {2}, publisher = {International Statistical Institute}, address = {The Hague}, issn = {1350-7265}, doi = {10.3150/19-BEJ1139}, pages = {1070 -- 1097}, year = {2020}, abstract = {The estimation of a log-concave density on R is a canonical problem in the area of shape-constrained nonparametric inference. We present a Bayesian nonparametric approach to this problem based on an exponentiated Dirichlet process mixture prior and show that the posterior distribution converges to the log-concave truth at the (near-) minimax rate in Hellinger distance. Our proof proceeds by establishing a general contraction result based on the log-concave maximum likelihood estimator that prevents the need for further metric entropy calculations. We further present computationally more feasible approximations and both an empirical and hierarchical Bayes approach. All priors are illustrated numerically via simulations.}, language = {en} } @article{RabeChandraKruegeletal.2021, author = {Rabe, Maximilian Michael and Chandra, Johan and Kr{\"u}gel, Andr{\´e} and Seelig, Stefan A. and Vasishth, Shravan and Engbert, Ralf}, title = {A bayesian approach to dynamical modeling of eye-movement control in reading of normal, mirrored, and scrambled texts}, series = {Psychological Review}, volume = {128}, journal = {Psychological Review}, number = {5}, publisher = {American Psychological Association}, address = {Washington}, issn = {0033-295X}, doi = {10.1037/rev0000268}, pages = {803 -- 823}, year = {2021}, abstract = {In eye-movement control during reading, advanced process-oriented models have been developed to reproduce behavioral data. So far, model complexity and large numbers of model parameters prevented rigorous statistical inference and modeling of interindividual differences. Here we propose a Bayesian approach to both problems for one representative computational model of sentence reading (SWIFT; Engbert et al., Psychological Review, 112, 2005, pp. 777-813). We used experimental data from 36 subjects who read the text in a normal and one of four manipulated text layouts (e.g., mirrored and scrambled letters). The SWIFT model was fitted to subjects and experimental conditions individually to investigate between- subject variability. Based on posterior distributions of model parameters, fixation probabilities and durations are reliably recovered from simulated data and reproduced for withheld empirical data, at both the experimental condition and subject levels. A subsequent statistical analysis of model parameters across reading conditions generates model-driven explanations for observable effects between conditions.}, language = {en} } @article{ThevesTaktikosZaburdaevetal.2013, author = {Theves, Matthias and Taktikos, Johannes and Zaburdaev, Vasily and Stark, Holger and Beta, Carsten}, title = {A bacterial swimmer with two alternating speeds of propagation}, series = {Biophysical journal}, volume = {105}, journal = {Biophysical journal}, number = {8}, publisher = {Cell Press}, address = {Cambridge}, issn = {0006-3495}, doi = {10.1016/j.bpj.2013.08.047}, pages = {1915 -- 1924}, year = {2013}, abstract = {We recorded large data sets of swimming trajectories of the soil bacterium Pseudomonas putida. Like other prokaryotic swimmers, P. putida exhibits a motion pattern dominated by persistent runs that are interrupted by turning events. An in-depth analysis of their swimming trajectories revealed that the majority of the turning events is characterized by an angle of phi(1) = 180 degrees (reversals). To a lesser extent, turning angles of phi(2 Sigma Sigma Sigma Sigma) = 00 are also found. Remarkably, we observed that, upon a reversal, the swimming speed changes by a factor of two on average a prominent feature of the motion pattern that, to our knowledge, has not been reported before. A theoretical model, based on the experimental values for the average run time and the rotational diffusion, recovers the mean-square displacement of P. putida if the two distinct swimming speeds are taken into account. Compared to a swimmer that moves with a constant intermediate speed, the mean-square displacement is strongly enhanced. We furthermore observed a negative dip in the directional autocorrelation at intermediate times, a feature that is only recovered in an extended model, where the nonexponential shape of the run-time distribution is taken into account.}, language = {en} } @article{RuzanskiSmirnovaRejzeketal.2013, author = {Ruzanski, Christian and Smirnova, Julia and Rejzek, Martin and Cockburn, Darrell and Pedersen, Henriette L. and Pike, Marilyn and Willats, William G. T. and Svensson, Birte and Steup, Martin and Ebenh{\"o}h, Oliver and Smith, Alison M. and Field, Robert A.}, title = {A bacterial glucanotransferase can replace the complex maltose metabolism required for starch to sucrose conversion in leaves at night}, series = {The journal of biological chemistry}, volume = {288}, journal = {The journal of biological chemistry}, number = {40}, publisher = {American Society for Biochemistry and Molecular Biology}, address = {Bethesda}, issn = {0021-9258}, doi = {10.1074/jbc.M113.497867}, pages = {28581 -- 28598}, year = {2013}, abstract = {Controlled conversion of leaf starch to sucrose at night is essential for the normal growth of Arabidopsis. The conversion involves the cytosolic metabolism of maltose to hexose phosphates via an unusual, multidomain protein with 4-glucanotransferase activity, DPE2, believed to transfer glucosyl moieties to a complex heteroglycan prior to their conversion to hexose phosphate via a cytosolic phosphorylase. The significance of this complex pathway is unclear; conversion of maltose to hexose phosphate in bacteria proceeds via a more typical 4-glucanotransferase that does not require a heteroglycan acceptor. It has recently been suggested that DPE2 generates a heterogeneous series of terminal glucan chains on the heteroglycan that acts as a glucosyl buffer to ensure a constant rate of sucrose synthesis in the leaf at night. Alternatively, DPE2 and/or the heteroglycan may have specific properties important for their function in the plant. To distinguish between these ideas, we compared the properties of DPE2 with those of the Escherichia coli glucanotransferase MalQ. We found that MalQ cannot use the plant heteroglycan as an acceptor for glucosyl transfer. However, experimental and modeling approaches suggested that it can potentially generate a glucosyl buffer between maltose and hexose phosphate because, unlike DPE2, it can generate polydisperse malto-oligosaccharides from maltose. Consistent with this suggestion, MalQ is capable of restoring an essentially wild-type phenotype when expressed in mutant Arabidopsis plants lacking DPE2. In light of these findings, we discuss the possible evolutionary origins of the complex DPE2-heteroglycan pathway.}, language = {en} } @article{LeongRaffeinerSpintietal.2022, author = {Leong, Jia Xuan and Raffeiner, Margot and Spinti, Daniela and Langin, Gautier and Franz-Wachtel, Mirita and Guzman, Andrew R. and Kim, Jung-Gun and Pandey, Pooja and Minina, Alyona E. and Macek, Boris and Hafren, Anders and Bozkurt, Tolga O. and Mudgett, Mary Beth and B{\"o}rnke, Frederik and Hofius, Daniel and Uestuen, Suayib}, title = {A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component}, series = {The EMBO journal}, volume = {41}, journal = {The EMBO journal}, number = {13}, publisher = {Wiley}, address = {Hoboken}, issn = {1460-2075}, doi = {10.15252/embj.2021110352}, pages = {17}, year = {2022}, abstract = {Beyond its role in cellular homeostasis, autophagy plays anti- and promicrobial roles in host-microbe interactions, both in animals and plants. One prominent role of antimicrobial autophagy is to degrade intracellular pathogens or microbial molecules, in a process termed xenophagy. Consequently, microbes evolved mechanisms to hijack or modulate autophagy to escape elimination. Although well-described in animals, the extent to which xenophagy contributes to plant-bacteria interactions remains unknown. Here, we provide evidence that Xanthomonas campestris pv. vesicatoria (Xcv) suppresses host autophagy by utilizing type-III effector XopL. XopL interacts with and degrades the autophagy component SH3P2 via its E3 ligase activity to promote infection. Intriguingly, XopL is targeted for degradation by defense-related selective autophagy mediated by NBR1/Joka2, revealing a complex antagonistic interplay between XopL and the host autophagy machinery. Our results implicate plant antimicrobial autophagy in the depletion of a bacterial virulence factor and unravel an unprecedented pathogen strategy to counteract defense-related autophagy in plant-bacteria interactions.}, language = {en} } @article{WeidleWiesenbergElSharkawyetal.2022, author = {Weidle, Christian and Wiesenberg, Lars and El-Sharkawy, Amr and Kr{\"u}ger, Frank and Scharf, Andreas and Agard, Philippe and Meier, Thomas}, title = {A 3-D crustal shear wave velocity model and Moho map below the Semail Ophiolite, eastern Arabia}, series = {Geophysical journal international}, volume = {231}, journal = {Geophysical journal international}, number = {2}, publisher = {Oxford University Press}, address = {Oxford}, issn = {0956-540X}, doi = {10.1093/gji/ggac223}, pages = {817 -- 834}, year = {2022}, abstract = {The Semail Ophiolite in eastern Arabia is the largest and best-exposed slice of oceanic lithosphere on land. Detailed knowledge of the tectonic evolution of the shallow crust, in particular during and after ophiolite obduction in Late Cretaceous times is contrasted by few constraints on physical and compositional properties of the middle and lower continental crust below the obducted units. The role of inherited, pre-obduction crustal architecture remains therefore unaccounted for in our understanding of crustal evolution and the present-day geology. Based on seismological data acquired during a 27-month campaign in northern Oman, Ambient Seismic Noise Tomography and Receiver Function analysis provide for the first time a 3-D radially anisotropic shear wave velocity (V-S) model and a consistent Moho map below the iconic Semail Ophiolite. The model highlights deep crustal boundaries that segment the eastern Arabian basement in two distinct units. The previously undescribed Western Jabal Akhdar Zone separates Arabian crust with typical continental properties and a thickness of similar to 40-45 km in the northwest from a compositionally different terrane in the southeast that is interpreted as a terrane accreted during the Pan-African orogeny in Neoproterozoic times. East of the Ibra Zone, another deep crustal boundary, crustal thickness decreases to 30-35 km and very high lower crustal V-S suggest large-scale mafic intrusions into, and possible underplating of the Arabian continental crust that occurred most likely during Permian breakup of Pangea. Mafic reworking is sharply bounded by the (upper crustal) Semail Gap Fault Zone, northwest of which no such high velocities are found in the crust. Topography of the Oman Mountains is supported by a mild crustal root and Moho depth below the highest topography, the Jabal Akhdar Dome, is similar to 42 km. Radial anisotropy is robustly resolved in the upper crust and aids in discriminating dipping allochthonous units from autochthonous sedimentary rocks that are indistinguishable by isotropic V-S alone. Lateral thickness variations of the ophiolite highlight the Haylayn Ophiolite Massif on the northern flank of Jabal Akhdar Dome and the Hawasina Window as the deepest reaching unit. Ophiolite thickness is similar to 10 km in the southern and northern massifs, and <= 5 km elsewhere.}, language = {en} } @article{SrivastavaKehrigKanthariaetal.2015, author = {Srivastava, S. and Kehrig, C. and Kantharia, N. G. and P{\´e}rez-Montero, E. and V{\´i}lchez, J. M. and Iglesias-P{\´a}ramo, J. and Janardhan, P.}, title = {A 2D view of Wolf-Rayet Galaxies}, series = {Wolf-Rayet Stars : Proceedings of an International Workshop held in Potsdam, Germany, 1.-5. June 2015}, journal = {Wolf-Rayet Stars : Proceedings of an International Workshop held in Potsdam, Germany, 1.-5. June 2015}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-87650}, pages = {59 -- 62}, year = {2015}, abstract = {The main objective of this work is to investigate the evolution of massive stars, and the interplay between them and the ionized gas for a sample of local metal-poor Wolf-Rayet galaxies. Optical integral field spectrocopy was used in combination with multi-wavelength radio data. Combining optical and radio data, we locate Wolf-Rayet stars and supernova remnants across the Wolf-Rayet galaxies to study the spatial correlation between them. This study will shed light on the massive star formation and its feedback, and will help us to better understand distant star-forming galaxies.}, language = {en} } @article{FreybourgerKruegerAchauer1999, author = {Freybourger, Marion and Kr{\"u}ger, Frank and Achauer, Ulrich}, title = {A 22 degree long seismic profile for the study of the top D"}, year = {1999}, language = {en} } @article{BalaganskyTimmermanKozlovaetal.2001, author = {Balagansky, V. V. and Timmerman, Martin Jan and Kozlova, N. Ye. and Kisilitsyn, R. V.}, title = {A 2.44 Ga old mafic dyke swarm in the Kolvitsa Belt, Kola Peninsula, Russia: implications for the early Palaeoproterozoic tectonics in the north-eastern Fennoscandian Shield}, year = {2001}, language = {en} } @article{WichuraJacobsLinetal.2015, author = {Wichura, Henry and Jacobs, Louis L. and Lin, Andrew and Polcyn, Michael J. and Manthi, Fredrick K. and Winkler, Dale A. and Strecker, Manfred and Clemens, Matthew}, title = {A 17-My-old whale constrains onset of uplift and climate change in east Africa}, series = {Proceedings of the National Academy of Sciences of the United States of America}, volume = {112}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, number = {13}, publisher = {National Acad. of Sciences}, address = {Washington}, issn = {0027-8424}, doi = {10.1073/pnas.1421502112}, pages = {3910 -- 3915}, year = {2015}, abstract = {Timing and magnitude of surface uplift are key to understanding the impact of crustal deformation and topographic growth on atmospheric circulation, environmental conditions, and surface processes. Uplift of the East African Plateau is linked to mantle processes, but paleoaltimetry data are too scarce to constrain plateau evolution and subsequent vertical motions associated with rifting. Here, we assess the paleotopographic implications of a beaked whale fossil (Ziphiidae) from the Turkana region of Kenya found 740 km inland from the present-day coastline of the Indian Ocean at an elevation of 620 m. The specimen is similar to 17 My old and represents the oldest derived beaked whale known, consistent with molecular estimates of the emergence of modern straptoothed whales (Mesoplodon). The whale traveled from the Indian Ocean inland along an eastward-directed drainage system controlled by the Cretaceous Anza Graben and was stranded slightly above sea level. Surface uplift from near sea level coincides with paleoclimatic change from a humid environment to highly variable and much drier conditions, which altered biotic communities and drove evolution in east Africa, including that of primates.}, language = {en} } @article{IsaevaKuznetsovSataev2012, author = {Isaeva, Olga B. and Kuznetsov, Sergey P. and Sataev, Igor R.}, title = {A "saddle-node" bifurcation scenario for birth or destruction of a Smale-Williams solenoid}, series = {Chaos : an interdisciplinary journal of nonlinear science}, volume = {22}, journal = {Chaos : an interdisciplinary journal of nonlinear science}, number = {4}, publisher = {American Institute of Physics}, address = {Melville}, issn = {1054-1500}, doi = {10.1063/1.4766590}, pages = {7}, year = {2012}, abstract = {Formation or destruction of hyperbolic chaotic attractor under parameter variation is considered with an example represented by Smale-Williams solenoid in stroboscopic Poincare map of two alternately excited non-autonomous van der Pol oscillators. The transition occupies a narrow but finite parameter interval and progresses in such way that periodic orbits constituting a "skeleton" of the attractor undergo saddle-node bifurcation events involving partner orbits from the attractor and from a non-attracting invariant set, which forms together with its stable manifold a basin boundary of the attractor.}, language = {en} } @article{GrudenHrenHermanetal.2012, author = {Gruden, Kristina and Hren, Matjaz and Herman, Ana and Blejec, Andrej and Albrecht, Tanja and Selbig, Joachim and Bauer, Christian G. and Schuchardt, Johannes and Or-Guil, Michal and Zupancic, Klemen and Svajger, Urban and Stabuc, Borut and Ihan, Alojz and Kopitar, Andreja Natasa and Ravnikar, Maja and Knezevic, Miomir and Rozman, Primoz and Jeras, Matjaz}, title = {A "Crossomics" study analysing variability of different components in peripheral blood of healthy caucasoid individuals}, series = {PLoS one}, volume = {7}, journal = {PLoS one}, number = {1}, publisher = {PLoS}, address = {San Fransisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0028761}, pages = {12}, year = {2012}, abstract = {Background: Different immunotherapy approaches for the treatment of cancer and autoimmune diseases are being developed and tested in clinical studies worldwide. Their resulting complex experimental data should be properly evaluated, therefore reliable normal healthy control baseline values are indispensable. Methodology/Principal Findings: To assess intra- and inter-individual variability of various biomarkers, peripheral blood of 16 age and gender equilibrated healthy volunteers was sampled on 3 different days within a period of one month. Complex "crossomics'' analyses of plasma metabolite profiles, antibody concentrations and lymphocyte subset counts as well as whole genome expression profiling in CD4(+)T and NK cells were performed. Some of the observed age, gender and BMI dependences are in agreement with the existing knowledge, like negative correlation between sex hormone levels and age or BMI related increase in lipids and soluble sugars. Thus we can assume that the distribution of all 39.743 analysed markers is well representing the normal Caucasoid population. All lymphocyte subsets, 20\% of metabolites and less than 10\% of genes, were identified as highly variable in our dataset. Conclusions/Significance: Our study shows that the intra- individual variability was at least two-fold lower compared to the inter-individual one at all investigated levels, showing the importance of personalised medicine approach from yet another perspective.}, language = {en} } @article{KoesterkeHamann2002, author = {Koesterke, Lars and Hamann, Wolf-Rainer}, title = {[WC]-type CSPN : clumping and wind-driving}, year = {2002}, abstract = {Many Central Stars of Planetary Nebulae are very similar to massive Wolf-Rayet stars of the carbon sequence with respect to their spectra, chemical composition and wind properties. Therefore their study opens an additional way towards the understanding of the Wolf-Rayet phenomenon. While the study of Line Profile Variation will be difficult, espescially for the very compact early types, the comparision with other hydrogen-deficient Central Stars illuminates the driving mechanism of their winds. We speculate that at least two ingredients are needed. The ionization of their atmpospheres has to be stratified to enable multi-scattering processes and the amount of carbon and oxygen has to be high (more than a few percent by mass).}, language = {en} } @article{SperlichKoeckerling2022, author = {Sperlich, Eric and K{\"o}ckerling, Martin}, title = {[Nb6Cl14(pyrazine)(4)], a versatile precursor for ligand-supported hexanuclear niobium cluster compounds: synthesis, characterization, follow-up reactions, and intermolecular interactions}, series = {Inorganic chemistry}, volume = {61}, journal = {Inorganic chemistry}, number = {5}, publisher = {American Chemical Society}, address = {Washington}, issn = {0020-1669}, doi = {10.1021/acs.inorgchem.1c03109}, pages = {2409 -- 2420}, year = {2022}, abstract = {The compound [Nb6Cl14(pyrazine)(4)]center dot 2CH(2)Cl(2) (1) was investigated for its suitability as a starting compound for new ligand-supported hexanuclear niobium cluster compounds. The synthesis, stability to air and increased temperature, solubility and usability for subsequent reactions of 1, and purification and separation of the reaction products are discussed. The compounds with cluster units [Nb6Cl14L4], where L = iso-quinoline N-oxides (2), 1,1-dimethylethylenediamines (3), or thiazoles (4), and [Nb6Cl14(PEt3)(3.76)(Et3PO)(0.24)]-[Nb6Cl14(MeCN)(4)]center dot 4MeCN (5) are presented as follow-up products. The crystal structures of compounds 1-5 are analyzed, and the structures are discussed with respect to their intraand intermolecular bonding situations and crystal packing. In addition to hydrogen bonds and pi-pi interactions, the appearance of chalcogen and halogen bonds and lone pair-pi interactions between Nb-6 cluster units was observed for the first time.}, language = {en} } @article{SperlichKoeckerling2021, author = {Sperlich, Eric and K{\"o}ckerling, Martin}, title = {[Nb6Cl12(CH3OH)4(OCH3)2] ⋅ DABCO ⋅ 1.66 CH2Cl2}, series = {Zeitschrift f{\"u}r anorganische und allgemeine Chemie : ZAAC = Journal of inorganic and general chemistry}, volume = {647}, journal = {Zeitschrift f{\"u}r anorganische und allgemeine Chemie : ZAAC = Journal of inorganic and general chemistry}, number = {18}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {0044-2313}, doi = {10.1002/zaac.202100138}, pages = {1759 -- 1763}, year = {2021}, abstract = {An easy-to-do synthesis for the hexanuclear niobium cluster compound [Nb6Cl12(CH3OH)(4)(OCH3)(2)] . DABCO . 1.66 CH2Cl2 has been developed. An one-pot reaction between the cluster precursor [Nb6Cl14(H2O)(4)] . 4H(2)O and methanol with the addition of DABCO leads to the crystallization of the title compound in high yield within a few minutes. The single-crystal X-ray structure of this cluster compound has been determined. Very strong, nearly symmetric intercluster hydrogen bonds Nb-6-MeO...H...OMe-Nb-6 are present between the cluster units. A bridging co-crystalline DABCO molecule is also involved in a three-dimensional hydrogen-bonding network.}, language = {en} } @article{ZehmFudickarHansetal.2008, author = {Zehm, Daniel and Fudickar, Werner and Hans, Melanie and Schilde, Uwe and Kelling, Alexandra and Linker, Torsten}, title = {9,10-Diarylanthracenes as molecular switches : syntheses, properties, isomerisations and their reactions with singlet oxygen}, issn = {0947-6539}, year = {2008}, abstract = {A series of 9,10-diarylanthracenes with various substituents at the ortho positions have been synthesised by palladium-catalysed cross-coupling reactions. Such compounds exhibit interesting physical properties and can be applied as molecular switches. Despite the high steric demand of the substituents, products were formed in moderate-to-good yields. In some cases, microwave conditions further improved yields. Bis-coupling afforded two isomers (syn and anti) that do not interconvert at room temperature. These products were easily separated and their relative stereochemistries were unequivocally assigned by NMR spectroscopy and X-ray analysis. The syn and anti isomers exhibit different physical properties (e.g., melting points and solubilities) and interconversion by rotation around the aryl-aryl axis commences at <100 °C for fluoro-substituted diarylanthracenes and at >300 °C for alkyl- or alkoxy-substituted diarylanthracenes. The reactions with singlet oxygen were studied separately and revealed different reactivities and reaction pathways. The yields and reactivities depend on the size and electronic nature of the substituents. The anti isomers form the same 9,10-endoperoxides as the syn species, occasionally accompanied by unexpected 1,4-endoperoxides as byproducts. Thermolysis of the endoperoxides exclusively yielded the syn isomers. The interesting rotation around the aryl-aryl axis allows the application of 9,10-diarylanthracenes as molecular switches, which are triggered by light and air under mild conditions. Finally, the oxygenation and thermolysis sequence provides a simple, synthetic access to a single stereoisomer (syn) from an unselective coupling step.}, language = {en} } @article{SchultzeFossSchmidt2020, author = {Schultze, Christiane and Foß, Stefan and Schmidt, Bernd}, title = {8-Prenylflavanones through microwave promoted tandem claisen rearrangement/6-endo-trig cyclization and cross metathesis}, series = {European journal of organic chemistry}, volume = {2020}, journal = {European journal of organic chemistry}, number = {47}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1434-193X}, doi = {10.1002/ejoc.202001378}, pages = {7373 -- 7384}, year = {2020}, abstract = {Prenylated flavanones were obtained from ortho-allyloxy chalcones through a one-pot sequence of Claisen rearrangement and 6-endo-trig cyclization, followed by olefin cross metathesis of the intermediate allyl flavanones with 2-methyl-2-butene. The synthetic utility of this route is illustrated for the synthesis of several naturally occurring prenyl flavanones.}, language = {en} } @article{YenesewTwinomuhweziKiremireetal.2009, author = {Yenesew, Abiy and Twinomuhwezi, Hannington and Kiremire, Bernard T. and Mbugua, Martin N. and Gitu, Peter M. and Heydenreich, Matthias and Peter, Martin G.}, title = {8-Methoxyneorautenol and radical scavenging flavonoids from Erythrina abyssinica}, issn = {1011-3924}, year = {2009}, abstract = {A new pterocarpan (named 8-methoxyneorautenol) was isolated from the acetone ext. of the root bark of Erythrina abyssinica. In addn., the known isoflavonoid derivs. eryvarin L, erycristagallin and shinpterocarpin were identified for the first time from the roots of this plant. The structures were detd. on the basis of spectroscopic evidence. The new compd. showed selective antimicrobial activity against Trichophyton mentagrophytes. The acetone ext. of the root bark of E. abyssinica showed radical scavenging activity towards 2,2-diphenyl-1-picrylhydrazyl radical (DPPH). The pterocarpenes, 3-hydroxy-9-methoxy-10-(3,3-dimethylallyl)pterocarpene and erycristagallin, were the most active constituents of the roots of this plant and showing dose-dependent activities similar to that of the std. quercetin. [on SciFinder (R)]}, language = {en} } @article{YenesewMushibeIndulietal.2005, author = {Yenesew, Abiy and Mushibe, E. K. and Induli, M. and Derese, Solomon and Midiwo, Jacob O. and Kabaru, Jacques M. and Heydenreich, Matthias and Koch, Andreas and Peter, Martin G.}, title = {7a-O-methyldeguelol, a modified rotenoid with an open ring-C, from the roots of Derris trifoloata}, issn = {0031-9422}, year = {2005}, abstract = {From the acetone extract of the roots of Derris trifoliata an isollavonoid derivative, named 7a-O- methyldeguelol, a modified rotenoid with an open ring-C, representing a new sub-class of isollavonoids (the sub-class is here named as rotenoloid), was isolated and characterised. In addition, the known rotenoids, rotenone, deguelin and alpha-toxicarol, were identified. The structures were determined on the basis of spectroscopic evidence. Rotenone and deguelin were identified as the larvicidal principles of the acetone extract of the roots of Derris trifoliata. (c) 2005 Elsevier Ltd. All rights reserved}, language = {en} } @article{Kosta1996, author = {Kosta, Peter}, title = {70 Years Existence of the Prague Linguistic Circle and 100th Anniversary of Roman Jakobsons Birthday, (Prag, 28. - 30.3.1996).}, year = {1996}, language = {en} } @article{MuivaMutisyaMachariaHeydenreichetal.2014, author = {Muiva-Mutisya, Lois and Macharia, Bernard and Heydenreich, Matthias and Koch, Andreas and Akala, Hoseah M. and Derese, Solomon and Omosa, Leonidah K. and Yusuf, Amir O. and Kamau, Edwin and Yenesew, Abiy}, title = {6 alpha-Hydroxy-alpha-toxicarol and (+)-tephrodin with antiplasmodial activities from Tephrosia species}, series = {Phytochemistry letters}, volume = {10}, journal = {Phytochemistry letters}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1874-3900}, doi = {10.1016/j.phytol.2014.09.002}, pages = {179 -- 183}, year = {2014}, abstract = {The CH2Cl2/MeOH (1: 1) extract of the roots of Tephrosia villosa showed good antiplasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 values of 3.1 +/- 0.4 and 1.3 +/- 0.3 mu g/mL, respectively. Chromatographic separation of the extract yielded a new rotenoid, 6 alpha-hydroxy-alpha-toxicarol, along with five known rotenoids, (rotenone, deguelin, sumatrol, 12 alpha-hydroxy-alpha-toxicarol and villosinol). Similar treatment of the extract of the stem of Tephrosia purpurea (IC50 = 4.1 +/- 0.4 and 1.9 +/- 0.2 mu g/mL against D6 and W2 strains of P. falciparum, respectively) yielded a new flavone having a unique substituent at C-7/C-8 [trivial name (+)-tephrodin], along with the known flavonoids tachrosin, obovatin methyl ether and derrone. The relative configuration and the most stable conformation in (+)-tephrodin was determined by NMR and theoretical energy calculations. The rotenoids and flavones tested showed good to moderate antiplasmodial activities (IC50 = 9 +/- 23 mu M). Whereas the cytotoxicity of rotenoids is known, the flavones (+)-tephrodin and tachrosin did not show significant cytotoxicity (IC50 > 100 mu M;) against mammalian African monkey kidney (vero) and human larynx carcinoma (HEp2) cell lines. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.}, language = {en} }