@article{UestuenSheikhGimenezIbanezetal.2016, author = {{\"U}st{\"u}n, Suayib and Sheikh, Arsheed and Gimenez-Ibanez, Selena and Jones, Alexandra and Ntoukakis, Vardis and B{\"o}rnke, Frederik}, title = {The Proteasome Acts as a Hub for Plant Immunity and Is Targeted by Pseudomonas Type III Effectors}, series = {Plant physiology : an international journal devoted to physiology, biochemistry, cellular and molecular biology, biophysics and environmental biology of plants}, volume = {172}, journal = {Plant physiology : an international journal devoted to physiology, biochemistry, cellular and molecular biology, biophysics and environmental biology of plants}, publisher = {American Society of Plant Physiologists}, address = {Rockville}, issn = {0032-0889}, doi = {10.1104/pp.16.00808}, pages = {1941 -- 1958}, year = {2016}, abstract = {Recent evidence suggests that the ubiquitin-proteasome system is involved in several aspects of plant immunity and that a range of plant pathogens subvert the ubiquitin-proteasome system to enhance their virulence. Here, we show that proteasome activity is strongly induced during basal defense in Arabidopsis (Arabidopsis thaliana). Mutant lines of the proteasome subunits RPT2a and RPN12a support increased bacterial growth of virulent Pseudomonas syringae pv tomato DC3000 (Pst) and Pseudomonas syringae pv maculicola ES4326. Both proteasome subunits are required for pathogen-associated molecular pattern-triggered immunity responses. Analysis of bacterial growth after a secondary infection of systemic leaves revealed that the establishment of systemic acquired resistance (SAR) is impaired in proteasome mutants, suggesting that the proteasome also plays an important role in defense priming and SAR. In addition, we show that Pst inhibits proteasome activity in a type III secretion-dependent manner. A screen for type III effector proteins from Pst for their ability to interfere with proteasome activity revealed HopM1, HopAO1, HopA1, and HopG1 as putative proteasome inhibitors. Biochemical characterization of HopM1 by mass spectrometry indicates that HopM1 interacts with several E3 ubiquitin ligases and proteasome subunits. This supports the hypothesis that HopM1 associates with the proteasome, leading to its inhibition. Thus, the proteasome is an essential component of pathogen-associated molecular pattern-triggered immunity and SAR, which is targeted by multiple bacterial effectors.}, language = {en} } @misc{DavosDohertyVolleretal.2016, author = {Davos, C. H. and Doherty, P. and Voller, Heinz and Salzwedel, Annett and Saure, D. and Metzendorf, M. I. and Jensen, K. and Schmid, J. P. and Rauch, B.}, title = {The prognostic effect of cardiac rehabilitation in the era of acute revascularization and statin therapy: the cardiac rehabilitation outcome study (CROS)}, series = {European heart journal}, volume = {37}, journal = {European heart journal}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0195-668X}, pages = {645 -- 645}, year = {2016}, language = {en} } @misc{RauchDavosDohertyetal.2016, author = {Rauch, Bernhard and Davos, Constantinos H. and Doherty, Patrick and Saure, Daniel and Metzendorf, Maria-Inti and Salzwedel, Annett and V{\"o}ller, Heinz and Jensen, Katrin and Schmid, Jean-Paul}, title = {The prognostic effect of cardiac rehabilitation in the era of acute revascularisation and statin therapy: A systematic review and meta-analysis of randomized and non-randomized studies - The Cardiac Rehabilitation Outcome Study (CROS)}, series = {European journal of preventive cardiology : the official ESC journal for primary \& secondary cardiovascular prevention, rehabilitation and sports cardiology}, volume = {23}, journal = {European journal of preventive cardiology : the official ESC journal for primary \& secondary cardiovascular prevention, rehabilitation and sports cardiology}, publisher = {Sage Publ.}, address = {London}, organization = {Univ Heidelberg; Heinrich-Heine Univ}, issn = {2047-4873}, doi = {10.1177/2047487316671181}, pages = {1914 -- 1939}, year = {2016}, abstract = {Background The prognostic effect of multi-component cardiac rehabilitation (CR) in the modern era of statins and acute revascularisation remains controversial. Focusing on actual clinical practice, the aim was to evaluate the effect of CR on total mortality and other clinical endpoints after an acute coronary event. Design Structured review and meta-analysis. Methods Randomised controlled trials (RCTs), retrospective controlled cohort studies (rCCSs) and prospective controlled cohort studies (pCCSs) evaluating patients after acute coronary syndrome (ACS), coronary artery bypass grafting (CABG) or mixed populations with coronary artery disease (CAD) were included, provided the index event was in 1995 or later. Results Out of n=18,534 abstracts, 25 studies were identified for final evaluation (RCT: n=1; pCCS: n=7; rCCS: n=17), including n=219,702 patients (after ACS: n=46,338; after CABG: n=14,583; mixed populations: n=158,781; mean follow-up: 40 months). Heterogeneity in design, biometrical assessment of results and potential confounders was evident. CCSs evaluating ACS patients showed a significantly reduced mortality for CR participants (pCCS: hazard ratio (HR) 0.37, 95\% confidence interval (CI) 0.20-0.69; rCCS: HR 0.64, 95\% CI 0.49-0.84; odds ratio 0.20, 95\% CI 0.08-0.48), but the single RCT fulfilling Cardiac Rehabilitation Outcome Study (CROS) inclusion criteria showed neutral results. CR participation was also associated with reduced mortality after CABG (rCCS: HR 0.62, 95\% CI 0.54-0.70) and in mixed CAD populations. Conclusions CR participation after ACS and CABG is associated with reduced mortality even in the modern era of CAD treatment. However, the heterogeneity of study designs and CR programmes highlights the need for defining internationally accepted standards in CR delivery and scientific evaluation.}, language = {en} } @misc{RauchDavosDohertyetal.2016, author = {Rauch, Bernhard and Davos, Constantinos H. and Doherty, Patrick and Saure, Daniel and Metzendorf, Maria-Inti and Salzwedel, Annett and V{\"o}ller, Heinz and Jensen, Katrin and Schmid, Jean-Paul}, title = {The prognostic effect of cardiac rehabilitation in the era of acute revascularisation and statin therapy}, series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, number = {418}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-405346}, pages = {26}, year = {2016}, abstract = {Background The prognostic effect of multi-component cardiac rehabilitation (CR) in the modern era of statins and acute revascularisation remains controversial. Focusing on actual clinical practice, the aim was to evaluate the effect of CR on total mortality and other clinical endpoints after an acute coronary event. Design Structured review and meta-analysis. Methods Randomised controlled trials (RCTs), retrospective controlled cohort studies (rCCSs) and prospective controlled cohort studies (pCCSs) evaluating patients after acute coronary syndrome (ACS), coronary artery bypass grafting (CABG) or mixed populations with coronary artery disease (CAD) were included, provided the index event was in 1995 or later. Results Out of n=18,534 abstracts, 25 studies were identified for final evaluation (RCT: n=1; pCCS: n=7; rCCS: n=17), including n=219,702 patients (after ACS: n=46,338; after CABG: n=14,583; mixed populations: n=158,781; mean follow-up: 40 months). Heterogeneity in design, biometrical assessment of results and potential confounders was evident. CCSs evaluating ACS patients showed a significantly reduced mortality for CR participants (pCCS: hazard ratio (HR) 0.37, 95\% confidence interval (CI) 0.20-0.69; rCCS: HR 0.64, 95\% CI 0.49-0.84; odds ratio 0.20, 95\% CI 0.08-0.48), but the single RCT fulfilling Cardiac Rehabilitation Outcome Study (CROS) inclusion criteria showed neutral results. CR participation was also associated with reduced mortality after CABG (rCCS: HR 0.62, 95\% CI 0.54-0.70) and in mixed CAD populations. Conclusions CR participation after ACS and CABG is associated with reduced mortality even in the modern era of CAD treatment. However, the heterogeneity of study designs and CR programmes highlights the need for defining internationally accepted standards in CR delivery and scientific evaluation.}, language = {en} } @article{JacobKirkici2016, author = {Jacob, Gunnar and Kirkici, Bilal}, title = {The processing of morphologically complex words in a specific speaker group A masked-priming study with Turkish heritage speakers}, series = {The mental lexicon}, volume = {11}, journal = {The mental lexicon}, publisher = {John Benjamins Publishing Co.}, address = {Amsterdam}, issn = {1871-1340}, doi = {10.1075/ml.11.2.06jac}, pages = {308 -- 328}, year = {2016}, abstract = {The present study investigates to what extent morphological priming varies across different groups of native speakers of a language. In two masked-priming experiments, we investigate the processing of morphologically complex Turkish words in Turkish heritage speakers raised and living in Germany. Materials and experimental design were based on K\&\#305;rk\&\#305;c\&\#305; and Clahsen's (2013) study on morphological processing in Turkish native speakers and L2 learners, allowing for direct comparisons between the three groups. Experiment 1 investigated priming effects for morphologically related prime-target pairs. Heritage speakers showed a similar pattern of results as the L1 comparison group, with significant priming effects for prime-target pairs with inflected primes (e.g. 'sorar-sor' asks-ask) as well as for prime-target pairs with derived primes (e.g. 'sa\&\#287;l\&\#305;k-sa\&\#287;' health-healthy). In Experiment 2, we measured priming effects for prime-target pairs which were semantically and morphologically unrelated, but only related with regard to orthographic overlap (e.g. 'devre-dev' period-giant). Unlike both L1 speakers raised in Turkey and highly proficient L2 learners, heritage speakers also showed significant priming effects in this condition. Our results suggest that heritage speakers differ from both native speakers and L2 learners in that they rely more on (orthographic) surface form properties of the stimulus during early stages of word recognition, at the expense of morphological decomposition.}, language = {en} } @article{BrentrupWilliamsonColomMonteroetal.2016, author = {Brentrup, Jennifer A. and Williamson, Craig E. and Colom-Montero, William and Eckert, Werner and de Eyto, Elvira and Grossart, Hans-Peter and Huot, Yannick and Isles, Peter D. F. and Knoll, Lesley B. and Leach, Taylor H. and McBride, Chris G. and Pierson, Don and Pomati, Francesco and Read, Jordan S. and Rose, Kevin C. and Samal, Nihar R. and Staehr, Peter A. and Winslow, Luke A.}, title = {The potential of high-frequency profiling to assess vertical and seasonal patterns of phytoplankton dynamics in lakes: an extension of the Plankton Ecology Group (PEG) model}, series = {Inland waters : journal of the International Society of Limnology}, volume = {6}, journal = {Inland waters : journal of the International Society of Limnology}, publisher = {Freshwater Biological Association}, address = {Ambleside}, issn = {2044-2041}, doi = {10.5268/IW-6.4.890}, pages = {565 -- 580}, year = {2016}, abstract = {The use of high-frequency sensors on profiling buoys to investigate physical, chemical, and biological processes in lakes is increasing rapidly. Profiling buoys with automated winches and sensors that collect high-frequency chlorophyll fluorescence (ChlF) profiles in 11 lakes in the Global Lake Ecological Observatory Network (GLEON) allowed the study of the vertical and temporal distribution of ChlF, including the formation of subsurface chlorophyll maxima (SSCM). The effectiveness of 3 methods for sampling phytoplankton distributions in lakes, including (1) manual profiles, (2) single-depth buoys, and (3) profiling buoys were assessed. High-frequency ChlF surface data and profiles were compared to predictions from the Plankton Ecology Group (PEG) model. The depth-integrated ChlF dynamics measured by the profiling buoy data revealed a greater complexity that neither conventional sampling nor the generalized PEG model captured. Conventional sampling techniques would have missed SSCM in 7 of 11 study lakes. Although surface-only ChlF data underestimated average water column ChlF, at times by nearly 2-fold in 4 of the lakes, overall there was a remarkable similarity between surface and mean water column data. Contrary to the PEG model's proposed negligible role for physical control of phytoplankton during the growing season, thermal structure and light availability were closely associated with ChlF seasonal depth distribution. Thus, an extension of the PEG model is proposed, with a new conceptual framework that explicitly includes physical metrics to better predict SSCM formation in lakes and highlight when profiling buoys are especially informative.}, language = {en} } @phdthesis{Schiller2016, author = {Schiller, Christof}, title = {The Politics of Welfare State Transformation in Germany}, series = {Routledge-EUI studies in the political economy of welfare ; 17}, journal = {Routledge-EUI studies in the political economy of welfare ; 17}, publisher = {Routledge}, address = {London}, isbn = {978-1-315-62390-0}, school = {Universit{\"a}t Potsdam}, pages = {273}, year = {2016}, language = {en} } @article{Borgnaes2016, author = {Borgn{\"a}s, Kajsa}, title = {The Policy Influence of Sustainability Indicators: Examining Use and Influence of Indicators in German Sustainability Policy Making}, series = {German politics}, volume = {25}, journal = {German politics}, publisher = {Elsevier}, address = {Abingdon}, issn = {0964-4008}, doi = {10.1080/09644008.2016.1193160}, pages = {480 -- 499}, year = {2016}, abstract = {In 2002 Germany adopted an ambitious national sustainability strategy, covering all three sustainability spheres and circling around 21 key indicators. The strategy stands out because of its relative stability over five consecutive government constellations, its high status and increasingly coercive nature. This article analyses the strategy's role in the policy process, focusing on the use and influence of indicators as a central steering tool. Contrasting rationalist and constructivist perspectives on the role of knowledge in policy, two factors, namely the level of consensus about policy goals and the institutional setting of the indicators, are found to explain differences in use and influence both across indicators and over time. Moreover, the study argues that the indicators have been part of a continuous process of 'structuring' in which conceptual and instrumental use together help structure the sustainability challenge in such a way that it becomes more manageable for government policy.}, language = {en} } @misc{Borgnaes2016, author = {Borgn{\"a}s, Kajsa}, title = {The Policy Influence of Sustainability Indicators}, doi = {10.1080/09644008.2016.1193160}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-96342}, pages = {1 -- 20}, year = {2016}, abstract = {In 2002 Germany adopted an ambitious national sustainability strategy, covering all three sustainability spheres and circling around 21 key indicators. The strategy stands out because of its relative stability over five consecutive government constellations, its high status and increasingly coercive nature. This article analyses the strategy's role in the policy process, focusing on the use and influence of indicators as a central steering tool. Contrasting rationalist and constructivist perspectives on the role of knowledge in policy, two factors, namely the level of consensus about policy goals and the institutional setting of the indicators, are found to explain differences in use and influence both across indicators and over time. Moreover, the study argues that the indicators have been part of a continuous process of 'structuring' in which conceptual and instrumental use together help structure the sustainability challenge in such a way that it becomes more manageable for government policy.}, language = {en} } @article{SedaghatmehrMuellerRoeberBalazadeh2016, author = {Sedaghatmehr, Mastoureh and M{\"u}ller-R{\"o}ber, Bernd and Balazadeh, Salma}, title = {The plastid metalloprotease FtsH6 and small heat shock protein HSP21 jointly regulate thermomemory in Arabidopsis}, series = {Nature Communications}, volume = {7}, journal = {Nature Communications}, publisher = {Nature Publ. Group}, address = {London}, issn = {2041-1723}, doi = {10.1038/ncomms12439}, pages = {14}, year = {2016}, abstract = {Acquired tolerance to heat stress is an increased resistance to elevated temperature following a prior exposure to heat. The maintenance of acquired thermotolerance in the absence of intervening stress is called 'thermomemory' but the mechanistic basis for this memory is not well defined. Here we show that Arabidopsis HSP21, a plastidial small heat shock protein that rapidly accumulates after heat stress and remains abundant during the thermomemory phase, is a crucial component of thermomemory. Sustained memory requires that HSP21 levels remain high. Through pharmacological interrogation and transcriptome profiling, we show that the plastid-localized metalloprotease FtsH6 regulates HSP21 abundance. Lack of a functional FtsH6 protein promotes HSP21 accumulation during the later stages of thermomemory and increases thermomemory capacity. Our results thus reveal the presence of a plastidial FtsH6-HSP21 control module for thermomemory in plants.}, language = {en} } @phdthesis{Breuer2016, author = {Breuer, David}, title = {The plant cytoskeleton as a transportation network}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-93583}, school = {Universit{\"a}t Potsdam}, pages = {164}, year = {2016}, abstract = {The cytoskeleton is an essential component of living cells. It is composed of different types of protein filaments that form complex, dynamically rearranging, and interconnected networks. The cytoskeleton serves a multitude of cellular functions which further depend on the cell context. In animal cells, the cytoskeleton prominently shapes the cell's mechanical properties and movement. In plant cells, in contrast, the presence of a rigid cell wall as well as their larger sizes highlight the role of the cytoskeleton in long-distance intracellular transport. As it provides the basis for cell growth and biomass production, cytoskeletal transport in plant cells is of direct environmental and economical relevance. However, while knowledge about the molecular details of the cytoskeletal transport is growing rapidly, the organizational principles that shape these processes on a whole-cell level remain elusive. This thesis is devoted to the following question: How does the complex architecture of the plant cytoskeleton relate to its transport functionality? The answer requires a systems level perspective of plant cytoskeletal structure and transport. To this end, I combined state-of-the-art confocal microscopy, quantitative digital image analysis, and mathematically powerful, intuitively accessible graph-theoretical approaches. This thesis summarizes five of my publications that shed light on the plant cytoskeleton as a transportation network: (1) I developed network-based frameworks for accurate, automated quantification of cytoskeletal structures, applicable in, e.g., genetic or chemical screens; (2) I showed that the actin cytoskeleton displays properties of efficient transport networks, hinting at its biological design principles; (3) Using multi-objective optimization, I demonstrated that different plant cell types sustain cytoskeletal networks with cell-type specific and near-optimal organization; (4) By investigating actual transport of organelles through the cell, I showed that properties of the actin cytoskeleton are predictive of organelle flow and provided quantitative evidence for a coordination of transport at a cellular level; (5) I devised a robust, optimization-based method to identify individual cytoskeletal filaments from a given network representation, allowing the investigation of single filament properties in the network context. The developed methods were made publicly available as open-source software tools. Altogether, my findings and proposed frameworks provide quantitative, system-level insights into intracellular transport in living cells. Despite my focus on the plant cytoskeleton, the established combination of experimental and theoretical approaches is readily applicable to different organisms. Despite the necessity of detailed molecular studies, only a complementary, systemic perspective, as presented here, enables both understanding of cytoskeletal function in its evolutionary context as well as its future technological control and utilization.}, language = {en} } @article{Denecke2016, author = {Denecke, Klaus-Dieter}, title = {The partial clone of linear terms}, series = {Siberian Mathematical Journal}, volume = {57}, journal = {Siberian Mathematical Journal}, publisher = {Pleiades Publ.}, address = {New York}, issn = {0037-4466}, doi = {10.1134/S0037446616040030}, pages = {589 -- 598}, year = {2016}, abstract = {Generalizing a linear expression over a vector space, we call a term of an arbitrary type tau linear if its every variable occurs only once. Instead of the usual superposition of terms and of the total many-sorted clone of all terms in the case of linear terms, we define the partial many-sorted superposition operation and the partial many-sorted clone that satisfies the superassociative law as weak identity. The extensions of linear hypersubstitutions are weak endomorphisms of this partial clone. For a variety V of one-sorted total algebras of type tau, we define the partial many-sorted linear clone of V as the partial quotient algebra of the partial many-sorted clone of all linear terms by the set of all linear identities of V. We prove then that weak identities of this clone correspond to linear hyperidentities of V.}, language = {en} } @article{OPUS4-50337, title = {The Oxford Handbook of Information Structure}, editor = {F{\´e}ry, Caroline and Ishihara, Shinichiro}, publisher = {Oxford University Press}, address = {Oxford}, isbn = {978-0-19-964267-0}, doi = {10.1093/oxfordhb/9780199642670.001.0001}, pages = {xxiv, 966}, year = {2016}, abstract = {This book offers a clear, critical, and comprehensive overview of theoretical and experimental work on information structure. Different chapters examine the main theories of information structure in syntax, phonology, and semantics as well as perspectives from psycholinguistics and other relevant fields. Following the editors' introduction the book is divided into four parts. The first, on theories of and theoretical perspectives on information structure, includes chapters on topic, prosody, and implicature. Part II covers a range of current issues in the field, including focus, quantification, and sign languages, while Part III is concerned with experimental approaches to information structure, including processes involved in its acquisition and comprehension. The final part contains a series of linguistic case studies drawn from a wide variety of the world's language families}, language = {en} } @article{RaelingSchroederWartenburger2016, author = {R{\"a}ling, Romy and Schr{\"o}der, Astrid and Wartenburger, Isabell}, title = {The origins of age of acquisition and typicality effects: Semantic processing in aphasia and the ageing brain}, series = {Neuropsychologia : an international journal in behavioural and cognitive neuroscience}, volume = {86}, journal = {Neuropsychologia : an international journal in behavioural and cognitive neuroscience}, publisher = {Elsevier}, address = {Oxford}, issn = {0028-3932}, doi = {10.1016/j.neuropsychologia.2016.04.019}, pages = {80 -- 92}, year = {2016}, abstract = {Age of acquisition (AOA) has frequently been shown to influence response times and accuracy rates in word processing and constitutes a meaningful variable in aphasic language processing, while its origin in the language processing system is still under debate. To find out where AOA originates and whether and how it is related to another important psycholinguistic variable, namely semantic typicality (TYP), we studied healthy, elderly controls and semantically impaired individuals using semantic priming. For this purpose, we collected reaction times and accuracy rates as well as event-related potential data in an auditory category-member-verification task. The present results confirm a semantic origin of TYP, but question the same for AOA while favouring its origin at the phonology-semantics interface. The data are further interpreted in consideration of recent theories of ageing. (C) 2016 Elsevier Ltd. All rights reserved.}, language = {en} } @misc{WutkeAnderssonBeneckeetal.2016, author = {Wutke, Saskia and Andersson, Leif and Benecke, Norbert and Sandoval-Castellanos, Edson and Gonzalez, Javier and Hallsson, Jon Hallsteinn and Lougas, Lembi and Magnell, Ola and Morales-Muniz, Arturo and Orlando, Ludovic and Palsdottir, Albina Hulda and Reissmann, Monika and Munoz-Rodriguez, Mariana B. and Ruttkay, Matej and Trinks, Alexandra and Hofreiter, Michael and Ludwig, Arne}, title = {The origin of ambling horses}, series = {Current biology}, volume = {26}, journal = {Current biology}, publisher = {Cell Press}, address = {Cambridge}, issn = {0960-9822}, doi = {10.1016/j.cub.2016.07.001}, pages = {R697 -- R699}, year = {2016}, abstract = {Horseback riding is the most fundamental use of domestic horses and has had a huge influence on the development of human societies for millennia. Over time, riding techniques and the style of riding improved. Therefore, horses with the ability to perform comfortable gaits (e.g. ambling or pacing), so-called 'gaited' horses, have been highly valued by humans, especially for long distance travel. Recently, the causative mutation for gaitedness in horses has been linked to a substitution causing a premature stop codon in the DMRT3 gene (DMRT3_Ser301STOP) [1]. In mice, Dmrt3 is expressed in spinal cord interneurons and plays an important role in the development of limb movement coordination [1]. Genotyping the position in 4396 modern horses from 141 breeds revealed that nowadays the mutated allele is distributed worldwide with an especially high frequency in gaited horses and breeds used for harness racing [2]. Here, we examine historic horse remains for the DMRT3 SNP, tracking the origin of gaitedness to Medieval England between 850 and 900 AD. The presence of the corresponding allele in Icelandic horses (9th-11th century) strongly suggests that ambling horses were brought from the British Isles to Iceland by Norse people. Considering the high frequency of the ambling allele in early Icelandic horses, we believe that Norse settlers selected for this comfortable mode of horse riding soon after arrival. The absence of the allele in samples from continental Europe (including Scandinavia) at this time implies that ambling horses may have spread from Iceland and maybe also the British Isles across the continent at a later date.}, language = {en} } @misc{Omerbasic2016, author = {Omerbasic, Alina}, title = {The Non-Identity Problem and the Ethics of Future People}, series = {Ethical theory and moral practice}, volume = {19}, journal = {Ethical theory and moral practice}, publisher = {Springer}, address = {Dordrecht}, issn = {1386-2820}, doi = {10.1007/s10677-015-9614-4}, pages = {273 -- 275}, year = {2016}, language = {en} } @phdthesis{Kopinski2016, author = {Kopinski, Stephan}, title = {The neuromuscular efficiency of lower back muscles in low back pain}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-101241}, school = {Universit{\"a}t Potsdam}, pages = {117}, year = {2016}, abstract = {BACKGROUND: The etiology of low back pain (LBP), one of the most prevalent and costly diseases of our time, is accepted to be multi-causal, placing functional factors in the focus of research. Thereby, pain models suggest a centrally controlled strategy of trunk stiffening in LBP. However, supporting biomechanical evidence is mostly limited to static measurements during maximum voluntary contractions (MVC), probably influenced by psychological factors in LBP. Alternatively, repeated findings indicate that the neuromuscular efficiency (NME), characterized by the strength-to-activation relationship (SAR), of lower back muscles is impaired in LBP. Therefore, a dynamic SAR protocol, consisting of normalized trunk muscle activation recordings during submaximal loads (SMVC) seems to be relevant. This thesis aimed to investigate the influence of LBP on the NME and activation pattern of trunk muscles during dynamic trunk extensions. METHODS: The SAR protocol consisted of an initial MVC reference trial (MVC1), followed by SMVCs at 20, 40, 60 and 80\% of MVC1 load. An isokinetic trunk dynamometer (Con-Trex TP, ROM: 45° flexion to 10° extension, velocity: 45°/s) and a trunk surface EMG setup (myon, up to 12 leads) was used. Extension torque output [Nm] and muscular activation [V] were assessed in all trials. Finally, another MVC trial was performed (MVC2) for reliability analysis. For SAR evaluation the SMVC trial values were normalized [\%MVC1] and compared inter- and intra-individually. The methodical validity of the approach was tested in an isometric SAR single-case pilot study (S1a: N = 2, female LBP patient vs. healthy male). In addition, the validity of the MVC reference method was verified by comparing different contraction modes (S1b: N = 17, healthy individuals). Next, the isokinetic protocol was validated in terms of content for its applicability to display known physiological differences between sexes in a cross-sectional study (S2: each n = 25 healthy males/females). Finally, the influence of acute pain on NME was investigated longitudinally by comparing N = 8 acute LBP patients with the retest after remission of pain (S3). The SAR analysis focused on normalized agonistic extensor activation and abdominal and synergistic extensor co-activation (t-tests, ANOVA, α = .05) as well as on reliability of MVC1/2 outcomes. RESULTS: During the methodological validation of the protocol (S1a), the isometric SAR was found to be descriptively different between individuals. Whereas torque output was highest during eccentric MVC, no relevant difference in peak EMG activation was found between contraction modes (S1b). The isokinetic SAR sex comparison (S2), though showing no significant overall effects, revealed higher normalized extensor activation at moderate submaximal loads in females (13 ± 4\%), primarily caused by pronounced thoracic activation. Similarly, co-activation analysis resulted in significantly higher antagonistic activation at moderate loads compared to males (33 ± 9\%). During intra-individual analysis of SAR in LBP patients (S3), a significant effect of pain status on the SAR has been identified, manifesting as increased normalized EMG activation of extensors during acute LBP (11 ± 8\%) particularly at high load. Abdominal co-activation tended to be elevated (27 ± 11\%) just as the thoracic extensor parts seemed to take over proportions of lumbar activation. All together, the M. erector spinae behaviour during the SAR protocol was rather linear with the tendency to rise exponentially during high loads. For the level of normalized EMG activation during SMVCs, a clear increasing trend from healthy males to females over to non-acute and acute LBP patients was discovered. This was associated by elevated antagonistic activation and a shift of synergistic towards lumbar extensor activation. The MVC data revealed overall good reliability, with clearly higher variability during acute LBP. DISCUSSION: The present thesis demonstrates that the NME of lower back muscles is impaired in LBP patients, especially during an acute pain episode. A new dynamic protocol has been developed that makes it possible to display the underlying SAR using normalized trunk muscle EMG during submaximal isokinetic loads. The protocol shows promise as a biomechanical tool for diagnostic analysis of NME in LBP patients and monitoring of rehabilitation progress. Furthermore, reliability not of maximum strength but rather of peak EMG of MVC measurements seems to be decreased in LBP patients. Meanwhile, the findings of this thesis largely substantiate the assumptions made by the recently presented 'motor adaptation to pain' model, suggesting a pain-related intra- and intermuscular activation redistribution affecting movement and stiffness of the trunk. Further research is needed to distinguish the grade of NME impairment between LBP subgroups.}, language = {en} } @unpublished{MeraTarkhanov2016, author = {Mera, Azal and Tarkhanov, Nikolai Nikolaevich}, title = {The Neumann problem after Spencer}, volume = {5}, number = {6}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {2193-6943}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-90631}, pages = {21}, year = {2016}, abstract = {When trying to extend the Hodge theory for elliptic complexes on compact closed manifolds to the case of compact manifolds with boundary one is led to a boundary value problem for the Laplacian of the complex which is usually referred to as Neumann problem. We study the Neumann problem for a larger class of sequences of differential operators on a compact manifold with boundary. These are sequences of small curvature, i.e., bearing the property that the composition of any two neighbouring operators has order less than two.}, language = {en} } @misc{Hoene2016, author = {H{\"o}ne, Christin}, title = {The Musical Novel: Imitation of Musical Structure, Performance and Reception in Contemporary Fiction}, series = {Geophysical research letters}, volume = {97}, journal = {Geophysical research letters}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0027-4224}, doi = {10.1093/ml/gcw001}, pages = {190 -- 191}, year = {2016}, language = {en} } @article{WrightAmesMitchelll2016, author = {Wright, Justin P. and Ames, Gregory M. and Mitchelll, Rachel M.}, title = {The more things change, the more they stay the same? When is trait variability important for stability of ecosystem function in a changing environment}, series = {Philosophical transactions of the Royal Society of London : B, Biological sciences}, volume = {371}, journal = {Philosophical transactions of the Royal Society of London : B, Biological sciences}, publisher = {Royal Society}, address = {London}, issn = {0962-8436}, doi = {10.1098/rstb.2015.0272}, pages = {7}, year = {2016}, abstract = {The importance of intraspecific trait variability for community dynamics and ecosystem functioning has been underappreciated. There are theoretical reasons for predicting that species that differ in intraspecific trait variability will also differ in their effects on ecosystem functioning, particularly in variable environments. We discuss whether species with greater trait variability are likely to exhibit greater temporal stability in their population dynamics, and under which conditions this might lead to stability in ecosystem functioning. Resolving this requires us to consider several questions. First, are species with high levels of variation for one trait equally variable in others? In particular, is variability in response and effects traits typically correlated? Second, what is the relative contribution of local adaptation and phenotypic plasticity to trait variability? If local adaptation dominates, then stability in function requires one of two conditions: (i) individuals of appropriate phenotypes present in the environment at high enough frequencies to allow for populations to respond rapidly to the changing environment, and (ii) high levels of dispersal and gene flow. While we currently lack sufficient information on the causes and distribution of variability in functional traits, filling in these key data gaps should increase our ability to predict how changing biodiversity will alter ecosystem functioning.}, language = {en} }