@phdthesis{Lenz2016,
  author    = {Lenz, Josefine},
  title     = {Thermokarst dynamics in central-eastern Beringia},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-101364},
  school      = {Universit{\"a}t Potsdam},
  pages     = {XII, 128, A-47},
  year      = {2016},
  abstract  = {Widespread landscape changes are presently observed in the Arctic and are most likely to accelerate in the future, in particular in permafrost regions which are sensitive to climate warming. To assess current and future developments, it is crucial to understand past environmental dynamics in these landscapes. Causes and interactions of environmental variability can hardly be resolved by instrumental records covering modern time scales. However, long-term environmental variability is recorded in paleoenvironmental archives. Lake sediments are important archives that allow reconstruction of local limnogeological processes as well as past environmental changes driven directly or indirectly by climate dynamics. This study aims at reconstructing Late Quaternary permafrost and thermokarst dynamics in central-eastern Beringia, the terrestrial land mass connecting Eurasia and North America during glacial sea-level low stands. In order to investigate development, processes and influence of thermokarst dynamics, several sediment cores from extant lakes and drained lake basins were analyzed to answer the following research questions: 1. When did permafrost degradation and thermokarst lake development take place and what were enhancing and inhibiting environmental factors? 2. What are the dominant processes during thermokarst lake development and how are they reflected in proxy records? 3. How did, and still do, thermokarst dynamics contribute to the inventory and properties of organic matter in sediments and the carbon cycle? Methods applied in this study are based upon a multi-proxy approach combining sedimentological, geochemical, geochronological, and micropaleontological analyses, as well as analyses of stable isotopes and hydrochemistry of pore-water and ice. Modern field observations of water quality and basin morphometrics complete the environmental investigations. The investigated sediment cores reveal permafrost degradation and thermokarst dynamics on different time scales. The analysis of a sediment core from GG basin on the northern Seward Peninsula (Alaska) shows prevalent terrestrial accumulation of yedoma throughout the Early to Mid Wisconsin with intermediate wet conditions at around 44.5 to 41.5 ka BP. This first wetland development was terminated by the accumulation of a 1-meter-thick airfall tephra most likely originating from the South Killeak Maar eruption at 42 ka BP. A depositional hiatus between 22.5 and 0.23 ka BP may indicate thermokarst lake formation in the surrounding of the site which forms a yedoma upland till today. The thermokarst lake forming GG basin initiated 230 ± 30 cal a BP and drained in Spring 2005 AD. Four years after drainage the lake talik was still unfrozen below 268 cm depth. A permafrost core from Mama Rhonda basin on the northern Seward Peninsula preserved a full lacustrine record including several lake phases. The first lake generation developed at 11.8 cal ka BP during the Lateglacial-Early Holocene transition; its old basin (Grandma Rhonda) is still partially preserved at the southern margin of the study basin. Around 9.0 cal ka BP a shallow and more dynamic thermokarst lake developed with actively eroding shorelines and potentially intermediate shallow water or wetland phases (Mama Rhonda). Mama Rhonda lake drainage at 1.1 cal ka BP was followed by gradual accumulation of terrestrial peat and top-down refreezing of the lake talik. A significant lower organic carbon content was measured in Grandma Rhonda deposits (mean TOC of 2.5 wt\%) than in Mama Rhonda deposits (mean TOC of 7.9 wt\%) highlighting the impact of thermokarst dynamics on biogeochemical cycling in different lake generations by thawing and mobilization of organic carbon into the lake system. Proximal and distal sediment cores from Peatball Lake on the Arctic Coastal Plain of Alaska revealed young thermokarst dynamics since about 1,400 years along a depositional gradient based on reconstructions from shoreline expansion rates and absolute dating results. After its initiation as a remnant pond of a previous drained lake basin, a rapidly deepening lake with increasing oxygenation of the water column is evident from laminated sediments, and higher Fe/Ti and Fe/S ratios in the sediment. The sediment record archived characterizing shifts in depositional regimes and sediment sources from upland deposits and re-deposited sediments from drained thaw lake basins depending on the gradually changing shoreline configuration. These changes are evident from alternating organic inputs into the lake system which highlights the potential for thermokarst lakes to recycle old carbon from degrading permafrost deposits of its catchment. The lake sediment record from Herschel Island in the Yukon (Canada) covers the full Holocene period. After its initiation as a thermokarst lake at 11.7 cal ka BP and intense thermokarst activity until 10.0 cal ka BP, the steady sedimentation was interrupted by a depositional hiatus at 1.6 cal ka BP which likely resulted from lake drainage or allochthonous slumping due to collapsing shore lines. The specific setting of the lake on a push moraine composed of marine deposits is reflected in the sedimentary record. Freshening of the maturing lake is indicated by decreasing electrical conductivity in pore-water. Alternation of marine to freshwater ostracods and foraminifera confirms decreasing salinity as well but also reflects episodical re-deposition of allochthonous marine sediments. Based on permafrost and lacustrine sediment records, this thesis shows examples of the Late Quaternary evolution of typical Arctic permafrost landscapes in central-eastern Beringia and the complex interaction of local disturbance processes, regional environmental dynamics and global climate patterns. This study confirms that thermokarst lakes are important agents of organic matter recycling in complex and continuously changing landscapes.},
  language  = {en}
}
@phdthesis{GonzalezCamargo2016,
  author    = {Gonzalez Camargo, Rodolfo},
  title     = {Insulin resistance in cancer cachexia and metabolic syndrome},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-100973},
  school      = {Universit{\"a}t Potsdam},
  pages     = {104},
  year      = {2016},
  abstract  = {The ever-increasing fat content in Western diet, combined with decreased levels of physical activity, greatly enhance the incidence of metabolic-related diseases. Cancer cachexia (CC) and Metabolic syndrome (MetS) are both multifactorial highly complex metabolism related syndromes, whose etiology is not fully understood, as the mechanisms underlying their development are not completely unveiled. Nevertheless, despite being considered "opposite sides", MetS and CC share several common issues such as insulin resistance and low-grade inflammation. In these scenarios, tissue macrophages act as key players, due to their capacity to produce and release inflammatory mediators. One of the main features of MetS is hyperinsulinemia, which is generally associated with an attempt of the β-cell to compensate for diminished insulin sensitivity (insulin resistance). There is growing evidence that hyperinsulinemia per se may contribute to the development of insulin resistance, through the establishment of low grade inflammation in insulin responsive tissues, especially in the liver (as insulin is secreted by the pancreas into the portal circulation). The hypothesis of the present study was that insulin may itself provoke an inflammatory response culminating in diminished hepatic insulin sensitivity. To address this premise, firstly, human cell line U937 differentiated macrophages were exposed to insulin, LPS and PGE2. In these cells, insulin significantly augmented the gene expression of the pro-inflammatory mediators IL-1β, IL-8, CCL2, Oncostatin M (OSM) and microsomal prostaglandin E2 synthase (mPGES1), and of the anti-inflammatory mediator IL-10. Moreover, the synergism between insulin and LPS enhanced the induction provoked by LPS in IL-1β, IL-8, IL-6, CCL2 and TNF-α gene. When combined with PGE2, insulin enhanced the induction provoked by PGE2 in IL-1β, mPGES1 and COX2, and attenuated the inhibition induced by PGE2 in CCL2 and TNF-α gene expression contributing to an enhanced inflammatory response by both mechanisms. Supernatants of insulin-treated U937 macrophages reduced the insulin-dependent induction of glucokinase in hepatocytes by 50\%. Cytokines contained in the supernatant of insulin-treated U937 macrophages also activated hepatocytes ERK1/2, resulting in inhibitory serine phosphorylation of the insulin receptor substrate. Additionally, the transcription factor STAT3 was activated by phosphorylation resulting in the induction of SOCS3, which is capable of interrupting the insulin receptor signal chain. MicroRNAs, non-coding RNAs linked to protein expression regulation, nowadays recognized as active players in the generation of several inflammatory disorders such as cancer and type II diabetes are also of interest. Considering that in cancer cachexia, patients are highly affected by insulin resistance and inflammation, control, non-cachectic and cachectic cancer patients were selected and the respective circulating levels of pro-inflammatory mediators and microRNA-21-5p, a posttranscriptional regulator of STAT3 expression, assessed and correlated. Cachectic patients circulating cytokines IL-6 and IL-8 levels were significantly higher than those of non-cachectic and controls, and the expression of microRNA-21-5p was significantly lower. Additionally, microRNA-21-5p reduced expression correlated negatively with IL-6 plasma levels. These results indicate that hyperinsulinemia per se might contribute to the low grade inflammation prevailing in MetS patients and thereby promote the development of insulin resistance particularly in the liver. Diminished MicroRNA-21-5p expression may enhance inflammation and STAT3 expression in cachectic patients, contributing to the development of insulin resistance.},
  language  = {en}
}
@phdthesis{Kopinski2016,
  author    = {Kopinski, Stephan},
  title     = {The neuromuscular efficiency of lower back muscles in low back pain},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-101241},
  school      = {Universit{\"a}t Potsdam},
  pages     = {117},
  year      = {2016},
  abstract  = {BACKGROUND: The etiology of low back pain (LBP), one of the most prevalent and costly diseases of our time, is accepted to be multi-causal, placing functional factors in the focus of research. Thereby, pain models suggest a centrally controlled strategy of trunk stiffening in LBP. However, supporting biomechanical evidence is mostly limited to static measurements during maximum voluntary contractions (MVC), probably influenced by psychological factors in LBP. Alternatively, repeated findings indicate that the neuromuscular efficiency (NME), characterized by the strength-to-activation relationship (SAR), of lower back muscles is impaired in LBP. Therefore, a dynamic SAR protocol, consisting of normalized trunk muscle activation recordings during submaximal loads (SMVC) seems to be relevant. This thesis aimed to investigate the influence of LBP on the NME and activation pattern of trunk muscles during dynamic trunk extensions. METHODS: The SAR protocol consisted of an initial MVC reference trial (MVC1), followed by SMVCs at 20, 40, 60 and 80\% of MVC1 load. An isokinetic trunk dynamometer (Con-Trex TP, ROM: 45° flexion to 10° extension, velocity: 45°/s) and a trunk surface EMG setup (myon, up to 12 leads) was used. Extension torque output [Nm] and muscular activation [V] were assessed in all trials. Finally, another MVC trial was performed (MVC2) for reliability analysis. For SAR evaluation the SMVC trial values were normalized [\%MVC1] and compared inter- and intra-individually. The methodical validity of the approach was tested in an isometric SAR single-case pilot study (S1a: N = 2, female LBP patient vs. healthy male). In addition, the validity of the MVC reference method was verified by comparing different contraction modes (S1b: N = 17, healthy individuals). Next, the isokinetic protocol was validated in terms of content for its applicability to display known physiological differences between sexes in a cross-sectional study (S2: each n = 25 healthy males/females). Finally, the influence of acute pain on NME was investigated longitudinally by comparing N = 8 acute LBP patients with the retest after remission of pain (S3). The SAR analysis focused on normalized agonistic extensor activation and abdominal and synergistic extensor co-activation (t-tests, ANOVA, α = .05) as well as on reliability of MVC1/2 outcomes. RESULTS: During the methodological validation of the protocol (S1a), the isometric SAR was found to be descriptively different between individuals. Whereas torque output was highest during eccentric MVC, no relevant difference in peak EMG activation was found between contraction modes (S1b). The isokinetic SAR sex comparison (S2), though showing no significant overall effects, revealed higher normalized extensor activation at moderate submaximal loads in females (13 ± 4\%), primarily caused by pronounced thoracic activation. Similarly, co-activation analysis resulted in significantly higher antagonistic activation at moderate loads compared to males (33 ± 9\%). During intra-individual analysis of SAR in LBP patients (S3), a significant effect of pain status on the SAR has been identified, manifesting as increased normalized EMG activation of extensors during acute LBP (11 ± 8\%) particularly at high load. Abdominal co-activation tended to be elevated (27 ± 11\%) just as the thoracic extensor parts seemed to take over proportions of lumbar activation. All together, the M. erector spinae behaviour during the SAR protocol was rather linear with the tendency to rise exponentially during high loads. For the level of normalized EMG activation during SMVCs, a clear increasing trend from healthy males to females over to non-acute and acute LBP patients was discovered. This was associated by elevated antagonistic activation and a shift of synergistic towards lumbar extensor activation. The MVC data revealed overall good reliability, with clearly higher variability during acute LBP. DISCUSSION: The present thesis demonstrates that the NME of lower back muscles is impaired in LBP patients, especially during an acute pain episode. A new dynamic protocol has been developed that makes it possible to display the underlying SAR using normalized trunk muscle EMG during submaximal isokinetic loads. The protocol shows promise as a biomechanical tool for diagnostic analysis of NME in LBP patients and monitoring of rehabilitation progress. Furthermore, reliability not of maximum strength but rather of peak EMG of MVC measurements seems to be decreased in LBP patients. Meanwhile, the findings of this thesis largely substantiate the assumptions made by the recently presented 'motor adaptation to pain' model, suggesting a pain-related intra- and intermuscular activation redistribution affecting movement and stiffness of the trunk. Further research is needed to distinguish the grade of NME impairment between LBP subgroups.},
  language  = {en}
}
@misc{Rossbach2016,
  type      = {Master Thesis},
  author    = {Roßbach, Naja Anja},
  title     = {Die Sprache in {\"U}berschriften und Zwischen{\"u}berschriften deutscher Tageszeitungen},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-101011},
  school      = {Universit{\"a}t Potsdam},
  pages     = {152},
  year      = {2016},
  abstract  = {Der deutsche Zeitungsmarkt ist von einem breiten Angebot {\"u}berregionaler Tageszeitungen gekennzeichnet, denen innerhalb der Bev{\"o}lkerung unterschiedliche politische Ausrichtungen zugeschrieben werden. Als konservatives Blatt gilt die „Frankfurter Allgemeine Zeitung" (F.A.Z.), wohingegen sich die „taz.die tageszeitung" (taz) durch eine linksalternative Orientierung auszeichnet. Ausgehend von diesem Unterschied untersucht die Arbeit die sprachliche Gestaltung der {\"U}berschriften, Unter- und Zwischenzeilen der F.A.Z. und der taz zu den Themen „Alternative f{\"u}r Deutschland" (AfD), „Nationalsozialistischer Untergrund" (NSU) und „Front National" (FN). Die qualitativ-quantitative Korpusuntersuchung fokussiert neben lexikalischen und syntaktischen auch sprachstilistische Faktoren, die eine Stellungnahme zu der Forschungsthese, dass mit der sprachlichen Formulierung der Haupt-, Unter- und Zwischenzeilen die politische Ausrichtung und ideologische Grundhaltung der Zeitungen deutlich wird, erlauben. Die Grundlage f{\"u}r die Analysen bildet ein konstruktivistischer Ansatz, der auf systemtheoretischen Annahmen beruht. Dadurch kann zum einen gezeigt werden, wie sich die Ergebnisse der sprachlichen Analysen mit den unterschiedlichen zugrunde liegenden Wirklichkeitskonstruktionen der Zeitungen verbinden lassen, zum anderen wird deutlich, dass sich die Formulierung der {\"U}berschriften auch auf die individuelle Realit{\"a}tskonstruktion der Rezipienten auswirkt. Die vergleichenden Auswertungen geben unterschiedlich gewichtete Hinweise auf die Einstellung der Kommunikatoren und best{\"a}tigen, dass die jeweiligen Perspektivierungen der Wirklichkeit sowie ideologischen Grundhaltungen der F.A.Z. und der taz bereits in der sprachlichen Gestaltung ihrer Titelkomplexe deutlich werden.},
  language  = {de}
}
@phdthesis{Engelmann2016,
  author    = {Engelmann, Felix},
  title     = {Toward an integrated model of sentence processing in reading},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-100864},
  school      = {Universit{\"a}t Potsdam},
  pages     = {xiii, 143},
  year      = {2016},
  abstract  = {In experiments investigating sentence processing, eye movement measures such as fixation durations and regression proportions while reading are commonly used to draw conclusions about processing difficulties. However, these measures are the result of an interaction of multiple cognitive levels and processing strategies and thus are only indirect indicators of processing difficulty. In order to properly interpret an eye movement response, one has to understand the underlying principles of adaptive processing such as trade-off mechanisms between reading speed and depth of comprehension that interact with task demands and individual differences. Therefore, it is necessary to establish explicit models of the respective mechanisms as well as their causal relationship with observable behavior. There are models of lexical processing and eye movement control on the one side and models on sentence parsing and memory processes on the other. However, no model so far combines both sides with explicitly defined linking assumptions. In this thesis, a model is developed that integrates oculomotor control with a parsing mechanism and a theory of cue-based memory retrieval. On the basis of previous empirical findings and independently motivated principles, adaptive, resource-preserving mechanisms of underspecification are proposed both on the level of memory access and on the level of syntactic parsing. The thesis first investigates the model of cue-based retrieval in sentence comprehension of Lewis \& Vasishth (2005) with a comprehensive literature review and computational modeling of retrieval interference in dependency processing. The results reveal a great variability in the data that is not explained by the theory. Therefore, two principles, 'distractor prominence' and 'cue confusion', are proposed as an extension to the theory, thus providing a more adequate description of systematic variance in empirical results as a consequence of experimental design, linguistic environment, and individual differences. In the remainder of the thesis, four interfaces between parsing and eye movement control are defined: Time Out, Reanalysis, Underspecification, and Subvocalization. By comparing computationally derived predictions with experimental results from the literature, it is investigated to what extent these four interfaces constitute an appropriate elementary set of assumptions for explaining specific eye movement patterns during sentence processing. Through simulations, it is shown how this system of in itself simple assumptions results in predictions of complex, adaptive behavior. In conclusion, it is argued that, on all levels, the sentence comprehension mechanism seeks a balance between necessary processing effort and reading speed on the basis of experience, task demands, and resource limitations. Theories of linguistic processing therefore need to be explicitly defined and implemented, in particular with respect to linking assumptions between observable behavior and underlying cognitive processes. The comprehensive model developed here integrates multiple levels of sentence processing that hitherto have only been studied in isolation. The model is made publicly available as an expandable framework for future studies of the interactions between parsing, memory access, and eye movement control.},
  language  = {en}
}
@book{Haase2016,
  author    = {Haase, Marina},
  title     = {Berufsschullandschaften in l{\"a}ndlichen R{\"a}umen},
  number    = {60},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-365-7},
  issn      = {0934-716X},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-89827},
  publisher      = {Universit{\"a}t Potsdam},
  pages     = {XXI, 462},
  year      = {2016},
  abstract  = {Seit Mitte der 2000er Jahre richtet sich angesichts der starken Sch{\"u}lerzahlenr{\"u}ckg{\"a}nge die wissenschaftliche und bildungspolitische Aufmerksamkeit wieder st{\"a}rker auf Fragen der Gestaltung beruflicher Bildung in l{\"a}ndlich-peripheren R{\"a}umen. Einerseits kn{\"u}pft sich an die demografische Entwicklung die Erwartung einer Entspannung der lange Zeit sehr prek{\"a}ren Ausbildungsplatzsituation in diesen R{\"a}umen. Andererseits ist offen, inwiefern mit den Anpassungsprozessen die Ausbildung neuer r{\"a}umlichen Disparit{\"a}ten verbunden ist, etwa durch die Schließung von Berufsschulen. Die Arbeit setzt sich mit der aktuellen Situation und dem Umgang mit Berufsschulen unter den folgenden Fragestellungen auseinander: Wie kann in Regionen mit d{\"u}nner Besiedlung auf der einen und einer schwierigen regional{\"o}konomischen Situation auf der anderen Seite diese komplexe Infrastruktur betrieben werden? Welche Steuerungsinstrumente kommen in dem anstehenden R{\"u}ckbauprozess zum Tragen und welche Rolle spielen demographische Entwicklungen, strukturelle Faktoren und Akteurshandeln? Ein besonderer Fokus liegt auf der theoretischen und empirischen Verkn{\"u}pfung von raumspezifischen Fragestellungen mit der Komplexit{\"a}t von Berufsschulen als ausdifferenzierte Institutionen zwischen Schulsystem und Wirtschaft. Untersucht wurde die Entwicklung des brandenburgischen Berufsschulnetzes ab den 1990er Jahren mit einer vertieften Fallstudie im Landkreis Uckermark. Entgegen der Annahme eines starken Einbruchs der Infrastrukturversorgung in Folge des Sch{\"u}lerzahlenr{\"u}ckganges wird gezeigt, dass sich die brandenburgische Berufsschullandschaft seit den 2000er Jahren durch eine relative Stabilit{\"a}t auszeichnet. Allerdings erfolgte eine berufsspezifische Ausd{\"u}nnung des Angebotes. Im Jahr 2013 fanden nur 41\% aller Auszubilden in ihrem jeweiligen Ausbildungsberuf ein relativ fl{\"a}chendeckendes Berufsschulnetz vor. Als Faktoren f{\"u}r gelingende Steuerungsprozesse (in l{\"a}ndlich-peripheren R{\"a}umen) zeigten sich das Subsidarit{\"a}tsprinzip, ein gemeinsam geteiltes Professionsverst{\"a}ndnis sowie die Orientierung auf einen gewissen r{\"a}umlichen Ausgleich. Erfolgreiche Interventionen gegen Konzentration basierten maßgeblich auf einem ausgepr{\"a}gten, fachlichen „Selbstbewusstsein" und Anspruch von Bildungsorganisationen. Demgegen{\"u}ber konnten unspezifische Bezugnahmen auf Peripherisierungen keine handlungswirksamen Strategien entfalten. Teilentwicklungen im Schulberufssystem sind durch die Expansion privater Berufsschulen in einen ausgepr{\"a}gten institutionellen Wandel eingebettet. Die Infrastrukturentwicklung f{\"u}hrte in diesem Segment zur Ausbildung eines spezifischen Marktes, der teilweise nur begrenzt einem klassischen Angebots-Nachfrage-Modell folgt und potentiell zu {\"U}berausbildung f{\"u}hrt. Die vorgefundenen Steuerungsformen sind angesichts von Ressourcenmangel, der sektoralen Zersplitterung sowie des Mangels an Institutionen f{\"u}r die Ausbildung von Regionen als Handlungsr{\"a}ume in der Berufsausbildung ambivalent. Der demografische Diskurs f{\"u}hrte (bisher) nicht zur Ausbildung von Steuerungsformen, welche die in der Infrastrukturgestaltung dominierenden, sektoralen Zust{\"a}ndigkeiten „{\"u}berwinden". Daher fungiert der Diskurs teilweise nur begrenzt als eine neue Orientierung f{\"u}r die Ausbildung von „peripheriespezifischen" Infrastrukturstrategien und alternativen Steuerungsmodellen. Er kann dann neue, {\"u}ber klassische Anpassungsprozesse hinausgehende, Optionen generieren, wenn er sich st{\"a}rker auf die Bedarfe der Akteure und Adressaten von Berufsbildung im l{\"a}ndlichen Raum bezieht und enger mit den Fachdiskursen verbindet.},
  language  = {de}
}
@phdthesis{Mueller2016,
  author    = {Mueller, Stefanie},
  title     = {Interacting with personal fabrication devices},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-100908},
  school      = {Universit{\"a}t Potsdam},
  pages     = {xxi, 108},
  year      = {2016},
  abstract  = {Personal fabrication tools, such as 3D printers, are on the way of enabling a future in which non-technical users will be able to create custom objects. However, while the hardware is there, the current interaction model behind existing design tools is not suitable for non-technical users. Today, 3D printers are operated by fabricating the object in one go, which tends to take overnight due to the slow 3D printing technology. Consequently, the current interaction model requires users to think carefully before printing as every mistake may imply another overnight print. Planning every step ahead, however, is not feasible for non-technical users as they lack the experience to reason about the consequences of their design decisions. In this dissertation, we propose changing the interaction model around personal fabrication tools to better serve this user group. We draw inspiration from personal computing and argue that the evolution of personal fabrication may resemble the evolution of personal computing: Computing started with machines that executed a program in one go before returning the result to the user. By decreasing the interaction unit to single requests, turn-taking systems such as the command line evolved, which provided users with feedback after every input. Finally, with the introduction of direct-manipulation interfaces, users continuously interacted with a program receiving feedback about every action in real-time. In this dissertation, we explore whether these interaction concepts can be applied to personal fabrication as well. We start with fabricating an object in one go and investigate how to tighten the feedback-cycle on an object-level: We contribute a method called low-fidelity fabrication, which saves up to 90\% fabrication time by creating objects as fast low-fidelity previews, which are sufficient to evaluate key design aspects. Depending on what is currently being tested, we propose different conversions that enable users to focus on different parts: faBrickator allows for a modular design in the early stages of prototyping; when users move on WirePrint allows quickly testing an object's shape, while Platener allows testing an object's technical function. We present an interactive editor for each technique and explain the underlying conversion algorithms. By interacting on smaller units, such as a single element of an object, we explore what it means to transition from systems that fabricate objects in one go to turn-taking systems. We start with a 2D system called constructable: Users draw with a laser pointer onto the workpiece inside a laser cutter. The drawing is captured with an overhead camera. As soon as the the user finishes drawing an element, such as a line, the constructable system beautifies the path and cuts it--resulting in physical output after every editing step. We extend constructable towards 3D editing by developing a novel laser-cutting technique for 3D objects called LaserOrigami that works by heating up the workpiece with the defocused laser until the material becomes compliant and bends down under gravity. While constructable and LaserOrigami allow for fast physical feedback, the interaction is still best described as turn-taking since it consists of two discrete steps: users first create an input and afterwards the system provides physical output. By decreasing the interaction unit even further to a single feature, we can achieve real-time physical feedback: Input by the user and output by the fabrication device are so tightly coupled that no visible lag exists. This allows us to explore what it means to transition from turn-taking interfaces, which only allow exploring one option at a time, to direct manipulation interfaces with real-time physical feedback, which allow users to explore the entire space of options continuously with a single interaction. We present a system called FormFab, which allows for such direct control. FormFab is based on the same principle as LaserOrigami: It uses a workpiece that when warmed up becomes compliant and can be reshaped. However, FormFab achieves the reshaping not based on gravity, but through a pneumatic system that users can control interactively. As users interact, they see the shape change in real-time. We conclude this dissertation by extrapolating the current evolution into a future in which large numbers of people use the new technology to create objects. We see two additional challenges on the horizon: sustainability and intellectual property. We investigate sustainability by demonstrating how to print less and instead patch physical objects. We explore questions around intellectual property with a system called Scotty that transfers objects without creating duplicates, thereby preserving the designer's copyright.},
  language  = {en}
}
@misc{SchildeKellingUmbreenetal.2016,
  author    = {Schilde, Uwe and Kelling, Alexandra and Umbreen, Sumaira and Linker, Torsten},
  title     = {Crystal structures of three bicyclic carbohydrate derivatives},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-100833},
  pages     = {6},
  year      = {2016},
  abstract  = {The title compounds, [(1R,3R,4R,5R,6S)-4,5-bis­(acet­yloxy)-7-oxo-2-oxabi­cyclo[4.2.0]octan-3-yl]methyl acetate, C14H18O8, (I), [(1S,4R,5S,6R)-5-acet­yloxy-7-hy­droxy­imino-2-oxobi­cyclo­[4.2.0]octan-4-yl acetate, C11H15NO6, (II), and [(3aR,5R,6R,7R,7aS)-6,7-bis­(acet­yloxy)-2-oxo­octa­hydro­pyrano[3,2-b]pyrrol-5-yl]methyl acetate, C14H19NO8, (III), are stable bicyclic carbohydrate derivatives. They can easily be synthesized in a few steps from commercially available glycals. As a result of the ring strain from the four-membered rings in (I) and (II), the conformations of the carbohydrates deviate strongly from the ideal chair form. Compound (II) occurs in the boat form. In the five-membered lactam (III), on the other hand, the carbohydrate adopts an almost ideal chair conformation. As a result of the distortion of the sugar rings, the configurations of the three bicyclic carbohydrate derivatives could not be determined from their NMR coupling constants. From our three crystal structure determinations, we were able to establish for the first time the absolute configurations of all new stereocenters of the carbohydrate rings.},
  language  = {en}
}
@misc{LahTrenseBenkeetal.2016,
  author    = {Lah, Ljerka and Trense, Daronja and Benke, Harald and Berggren, Per and Gunnlaugsson, Þorvaldur and Lockyer, Christina and {\"O}zt{\"u}rk, Ayaka and {\"O}zt{\"u}rk, Bayram and Pawliczka, Iwona and Roos, Anna and Siebert, Ursula and Sk{\´o}ra, Krzysztof and V{\´i}kingsson, G{\´i}sli and Tiedemann, Ralph},
  title     = {Spatially Explicit Analysis of Genome-Wide SNPs Detects Subtle Population Structure in a Mobile Marine Mammal, the Harbor Porpoise},
  issn      = {1866-8372},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-100813},
  pages     = {23 Seiten},
  year      = {2016},
  abstract  = {The population structure of the highly mobile marine mammal, the harbor porpoise (Phocoena phocoena), in the Atlantic shelf waters follows a pattern of significant isolation-by-distance. The population structure of harbor porpoises from the Baltic Sea, which is connected with the North Sea through a series of basins separated by shallow underwater ridges, however, is more complex. Here, we investigated the population differentiation of harbor porpoises in European Seas with a special focus on the Baltic Sea and adjacent waters, using a population genomics approach. We used 2872 single nucleotide polymorphisms (SNPs), derived from double digest restriction-site associated DNA sequencing (ddRAD-seq), as well as 13 microsatellite loci and mitochondrial haplotypes for the same set of individuals. Spatial principal components analysis (sPCA), and Bayesian clustering on a subset of SNPs suggest three main groupings at the level of all studied regions: the Black Sea, the North Atlantic, and the Baltic Sea. Furthermore, we observed a distinct separation of the North Sea harbor porpoises from the Baltic Sea populations, and identified splits between porpoise populations within the Baltic Sea. We observed a notable distinction between the Belt Sea and the Inner Baltic Sea sub-regions. Improved delineation of harbor porpoise population assignments for the Baltic based on genomic evidence is important for conservation management of this endangered cetacean in threatened habitats, particularly in the Baltic Sea proper. In addition, we show that SNPs outperform microsatellite markers and demonstrate the utility of RAD-tags from a relatively small, opportunistically sampled cetacean sample set for population diversity and divergence analysis.},
  language  = {en}
}
@phdthesis{Gopalakrishnan2016,
  author    = {Gopalakrishnan, Sathej},
  title     = {Mathematical modelling of host-disease-drug interactions in HIV disease},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-100100},
  school      = {Universit{\"a}t Potsdam},
  pages     = {121},
  year      = {2016},
  abstract  = {The human immunodeficiency virus (HIV) has resisted nearly three decades of efforts targeting a cure. Sustained suppression of the virus has remained a challenge, mainly due to the remarkable evolutionary adaptation that the virus exhibits by the accumulation of drug-resistant mutations in its genome. Current therapeutic strategies aim at achieving and maintaining a low viral burden and typically involve multiple drugs. The choice of optimal combinations of these drugs is crucial, particularly in the background of treatment failure having occurred previously with certain other drugs. An understanding of the dynamics of viral mutant genotypes aids in the assessment of treatment failure with a certain drug combination, and exploring potential salvage treatment regimens. Mathematical models of viral dynamics have proved invaluable in understanding the viral life cycle and the impact of antiretroviral drugs. However, such models typically use simplified and coarse-grained mutation schemes, that curbs the extent of their application to drug-specific clinical mutation data, in order to assess potential next-line therapies. Statistical models of mutation accumulation have served well in dissecting mechanisms of resistance evolution by reconstructing mutation pathways under different drug-environments. While these models perform well in predicting treatment outcomes by statistical learning, they do not incorporate drug effect mechanistically. Additionally, due to an inherent lack of temporal features in such models, they are less informative on aspects such as predicting mutational abundance at treatment failure. This limits their application in analyzing the pharmacology of antiretroviral drugs, in particular, time-dependent characteristics of HIV therapy such as pharmacokinetics and pharmacodynamics, and also in understanding the impact of drug efficacy on mutation dynamics. In this thesis, we develop an integrated model of in vivo viral dynamics incorporating drug-specific mutation schemes learned from clinical data. Our combined modelling approach enables us to study the dynamics of different mutant genotypes and assess mutational abundance at virological failure. As an application of our model, we estimate in vivo fitness characteristics of viral mutants under different drug environments. Our approach also extends naturally to multiple-drug therapies. Further, we demonstrate the versatility of our model by showing how it can be modified to incorporate recently elucidated mechanisms of drug action including molecules that target host factors. Additionally, we address another important aspect in the clinical management of HIV disease, namely drug pharmacokinetics. It is clear that time-dependent changes in in vivo drug concentration could have an impact on the antiviral effect, and also influence decisions on dosing intervals. We present a framework that provides an integrated understanding of key characteristics of multiple-dosing regimens including drug accumulation ratios and half-lifes, and then explore the impact of drug pharmacokinetics on viral suppression. Finally, parameter identifiability in such nonlinear models of viral dynamics is always a concern, and we investigate techniques that alleviate this issue in our setting.},
  language  = {en}
}
@phdthesis{Punz2016,
  author    = {Punz, Elisabeth},
  title     = {Effektivit{\"a}t fr{\"u}hzeitiger Interventionen zur Pr{\"a}vention von Lese- und Rechtschreibschwierigkeiten},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-96815},
  school      = {Universit{\"a}t Potsdam},
  pages     = {453},
  year      = {2016},
  abstract  = {Die vorliegende Studie besch{\"a}ftigt sich mit der F{\"o}rderung der Lese- und Schreibkompetenz in der Anfangsphase des Schriftspracherwerbs. Ziel der Untersuchung ist die Erprobung und Evaluierung fr{\"u}hzeitiger, diagnosegeleiteter Interventionen zur Pr{\"a}vention von Lese- und Rechtschreibschwierigkeiten. Im Unterschied zu vielen Studien in diesem Bereich werden alle Maßnahmen unter realen schulischen Bedingungen im Rahmen des Erstlese- und Schreibunterrichts durch die Klassenlehrer selbst durchgef{\"u}hrt, wobei diese von der Autorin unterst{\"u}tzt und begleitet werden. F{\"o}rder- und Prozessdiagnose sowie Elemente diagnosegeleiteter F{\"o}rderung werden aus Theorien und Forschungslage abgeleitet und zu einem Interventionsset verbunden. Die Effektivit{\"a}t der evidenzbasierten Maßnahmen wird durch Parallelgruppenvergleiche {\"u}berpr{\"u}ft. An der empirischen Untersuchung nahmen insgesamt 25 Schulklassen mit 560 Erstkl{\"a}sslern teil, geteilt in Versuchs- und Kontrollgruppe. Mit der Eingangsdiagnose am Schulbeginn wurden Voraussetzungen f{\"u}r den Schriftspracherwerb erhoben und mit der Evaluierungsdiagnose am Ende der ersten Schulstufe entwicklungsad{\"a}quate schriftsprachliche Kompetenzen auf der Wortebene {\"u}berpr{\"u}ft. Zus{\"a}tzlich erfasst wurden internale und externale Einflussfaktoren, deren Wirkung in der statistischen Auswertung ber{\"u}cksichtigt wurde. Alle Datenerhebungen wurden in Versuchs- und Kontrollgruppe durchgef{\"u}hrt, w{\"a}hrend die evidenzbasierten Treatments nur in der Versuchsgruppe stattfanden. Die Auswertung best{\"a}tigt mit signifikanten Ergebnissen den engen Zusammenhang zwischen der Phonologischen Bewusstheit zu Beginn des Schriftspracherwerbs und der Lese- und Rechtschreibf{\"a}higkeit am Ende der ersten Schulstufe sowie zwischen Famili{\"a}rer Literalit{\"a}t und Lesefertigkeit. Schriftsprachliche Vorkenntnisse weisen eine Tendenz zur Signifikanz hinsichtlich ihrer positiven Wirkung auf die Basale Lesefertigkeit auf. Eine h{\"o}chst signifikante positive Wirkung auf die Basale Lesefertigkeit zeigt die Druckschrift als Ausgangsschrift. Die Ergebnisse deuten auf eine {\"U}berlegenheit vorschulischer pr{\"a}literaler Fertigkeiten hinsichtlich ihrer Wirkung auf die Lese- und Rechtschreibfertigkeit am Ende der ersten Schulstufe gegen{\"u}ber F{\"o}rdermaßnahmen unter realen schulischen Bedingungen hin. Die positive Wirkung einer unverbundenen Ausgangsschrift auf den Leseerwerb betont die Wichtigkeit der Wahl der Ausgangsschrift. Im fr{\"u}hen Schriftspracherwerb sollte die Druckschrift f{\"u}r das Lesen und Schreiben verwendet werden.},
  language  = {de}
}
@misc{ThiekenKienzlerKreibichetal.2016,
  author    = {Thieken, Annegret and Kienzler, Sarah and Kreibich, Heidi and Kuhlicke, Christian and Kunz, Michael and M{\"u}hr, Bernhard and M{\"u}ller, Meike and Otto, Antje and Petrow, Theresia and Pisi, Sebastian and Schr{\"o}ter, Kai},
  title     = {Review of the flood risk management system in Germany after the major flood in 2013},
  issn      = {1866-8372},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-100600},
  pages     = {12},
  year      = {2016},
  abstract  = {Widespread flooding in June 2013 caused damage costs of €6 to 8 billion in Germany, and awoke many memories of the floods in August 2002, which resulted in total damage of €11.6 billion and hence was the most expensive natural hazard event in Germany up to now. The event of 2002 does, however, also mark a reorientation toward an integrated flood risk management system in Germany. Therefore, the flood of 2013 offered the opportunity to review how the measures that politics, administration, and civil society have implemented since 2002 helped to cope with the flood and what still needs to be done to achieve effective and more integrated flood risk management. The review highlights considerable improvements on many levels, in particular (1) an increased consideration of flood hazards in spatial planning and urban development, (2) comprehensive property-level mitigation and preparedness measures, (3) more effective flood warnings and improved coordination of disaster response, and (4) a more targeted maintenance of flood defense systems. In 2013, this led to more effective flood management and to a reduction of damage. Nevertheless, important aspects remain unclear and need to be clarified. This particularly holds for balanced and coordinated strategies for reducing and overcoming the impacts of flooding in large catchments, cross-border and interdisciplinary cooperation, the role of the general public in the different phases of flood risk management, as well as a transparent risk transfer system. Recurring flood events reveal that flood risk management is a continuous task. Hence, risk drivers, such as climate change, land-use changes, economic developments, or demographic change and the resultant risks must be investigated at regular intervals, and risk reduction strategies and processes must be reassessed as well as adapted and implemented in a dialogue with all stakeholders.},
  language  = {en}
}
@unpublished{VasilievTarkhanov2016,
  author    = {Vasiliev, Serguei and Tarkhanov, Nikolai Nikolaevich},
  title     = {Construction of series of perfect lattices by layer superposition},
  volume    = {5},
  number    = {11},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {2193-6943},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-100591},
  pages     = {11},
  year      = {2016},
  abstract  = {We construct a new series of perfect lattices in n dimensions by the layer superposition method of Delaunay-Barnes.},
  language  = {en}
}
@article{Franz2016,
  author    = {Franz, Norbert P.},
  title     = {Bibliographie zu Andrej Tarkovskijs Leben und Werk},
  series = {Andrej Tarkovskij: Klassiker - Классик - Classic - Classico : Beitr{\"a}ge zum internationalen Tarkovskij-Symposium an der Universit{\"a}t Potsdam ; Band 2},
  journal   = {Andrej Tarkovskij: Klassiker - Классик - Classic - Classico : Beitr{\"a}ge zum internationalen Tarkovskij-Symposium an der Universit{\"a}t Potsdam ; Band 2},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-352-7},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-100578},
  pages     = {587 -- 672},
  year      = {2016},
  language  = {de}
}
@article{Вардиц2016,
  author    = {Вардиц, Владислава},
  title     = {Андрей Тарковский и Ларс фон Триер},
  series = {Andrej Tarkovskij: Klassiker - Классик - Classic - Classico : Beitr{\"a}ge zum internationalen Tarkovskij-Symposium an der Universit{\"a}t Potsdam ; Band 2},
  journal   = {Andrej Tarkovskij: Klassiker - Классик - Classic - Classico : Beitr{\"a}ge zum internationalen Tarkovskij-Symposium an der Universit{\"a}t Potsdam ; Band 2},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-352-7},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-100562},
  pages     = {573 -- 586},
  year      = {2016},
  language  = {ru}
}
@article{Pellanda2016,
  author    = {Pellanda, Marina},
  title     = {Tarkovsky's legacy},
  series = {Andrej Tarkovskij: Klassiker - Классик - Classic - Classico : Beitr{\"a}ge zum internationalen Tarkovskij-Symposium an der Universit{\"a}t Potsdam ; Band 2},
  journal   = {Andrej Tarkovskij: Klassiker - Классик - Classic - Classico : Beitr{\"a}ge zum internationalen Tarkovskij-Symposium an der Universit{\"a}t Potsdam ; Band 2},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-352-7},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-100557},
  pages     = {549 -- 571},
  year      = {2016},
  language  = {en}
}
@article{Petzer2016,
  author    = {Petzer, Tatjana},
  title     = {„Vajanie iz vremeni"},
  series = {Andrej Tarkovskij: Klassiker - Классик - Classic - Classico : Beitr{\"a}ge zum internationalen Tarkovskij-Symposium an der Universit{\"a}t Potsdam ; Band 2},
  journal   = {Andrej Tarkovskij: Klassiker - Классик - Classic - Classico : Beitr{\"a}ge zum internationalen Tarkovskij-Symposium an der Universit{\"a}t Potsdam ; Band 2},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-352-7},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-100542},
  pages     = {519 -- 547},
  year      = {2016},
  language  = {de}
}
@article{Christians2016,
  author    = {Christians, Heiko},
  title     = {Die Museumsbesucher},
  series = {Andrej Tarkovskij: Klassiker - Классик - Classic - Classico : Beitr{\"a}ge zum internationalen Tarkovskij-Symposium an der Universit{\"a}t Potsdam ; Band 2},
  journal   = {Andrej Tarkovskij: Klassiker - Классик - Classic - Classico : Beitr{\"a}ge zum internationalen Tarkovskij-Symposium an der Universit{\"a}t Potsdam ; Band 2},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-352-7},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-100534},
  pages     = {505 -- 518},
  year      = {2016},
  language  = {de}
}
@article{Engel2016,
  author    = {Engel, Christine},
  title     = {Aleksej Balabanovs Dialog mit Andrej Tarkovskij},
  series = {Andrej Tarkovskij: Klassiker - Классик - Classic - Classico : Beitr{\"a}ge zum internationalen Tarkovskij-Symposium an der Universit{\"a}t Potsdam ; Band 2},
  journal   = {Andrej Tarkovskij: Klassiker - Классик - Classic - Classico : Beitr{\"a}ge zum internationalen Tarkovskij-Symposium an der Universit{\"a}t Potsdam ; Band 2},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-352-7},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-100521},
  pages     = {487 -- 504},
  year      = {2016},
  language  = {de}
}
@article{Paperny2016,
  author    = {Paperny, Vladimir},
  title     = {Andrej Tarkovskij and Andrej Končalovskij},
  series = {Andrej Tarkovskij: Klassiker - Классик - Classic - Classico : Beitr{\"a}ge zum internationalen Tarkovskij-Symposium an der Universit{\"a}t Potsdam ; Band 2},
  journal   = {Andrej Tarkovskij: Klassiker - Классик - Classic - Classico : Beitr{\"a}ge zum internationalen Tarkovskij-Symposium an der Universit{\"a}t Potsdam ; Band 2},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-352-7},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-100515},
  pages     = {471 -- 486},
  year      = {2016},
  language  = {en}
}