@article{MuellerUllmannSteinberg2011, author = {M{\"u}ller, Carsten and Ullmann, Kristina and Steinberg, Pablo}, title = {The grapevine-shoot extract Vineatrol30 Inhibits the chemically induced malignant transformation of BALB/c-3T3 Cells}, series = {Journal of medicinal food}, volume = {14}, journal = {Journal of medicinal food}, number = {1-2}, publisher = {Liebert}, address = {New Rochelle}, issn = {1096-620X}, doi = {10.1089/jmf.2010.0022}, pages = {34 -- 39}, year = {2011}, abstract = {Vineatrol (R) 30 (developed and produced jointly by Breko GmbH [Bremen, Germany] and Actichem [Montauban, France]) is a grapevine-shoot extract that contains resveratrol as well as considerable amounts of resveratrol oligomers. In the present study it is shown that Vineatrol30 at a noncytotoxic concentration of 2.3 mu g/mL significantly reduced the number of malignantly transformed foci induced by a sequential treatment of BALB/c-3T3 cells with 3-methylcholanthrene and 12-O-tetradecanoylphorbol 13-acetate in the so-called BALB/c-3T3 cell transformation assay. At a higher concentration Vineatrol30 drastically decreased the relative plating efficiency of the cells. Furthermore, the results suggest that the resveratrol oligomers present in Vineatrol30, independently from resveratrol itself, were indeed able to inhibit the formation of malignantly transformed BALB/c-3T3 foci.}, language = {en} } @article{XieWhiteWeberetal.2011, author = {Xie, Zai-Lai and White, Robin J. and Weber, Jens and Taubert, Andreas and Titirici, Magdalena M.}, title = {Hierarchical porous carbonaceous materials via ionothermal carbonization of carbohydrates}, series = {Journal of materials chemistry}, volume = {21}, journal = {Journal of materials chemistry}, number = {20}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {0959-9428}, doi = {10.1039/c1jm00013f}, pages = {7434 -- 7442}, year = {2011}, abstract = {We report on the ionothermal synthesis of porous carbon materials from a variety of carbohydrate precursors (i.e. D-glucose, D-fructose, D-xylose, and starch) using 1-butyl-3-methylimidazolium tetrachloroferrate(III), [Bmim][FeCl(4)] as a reusable solvent and catalyst. The carbon materials derived from these different carbohydrates are similar in terms of particle size and chemical composition, possessing relatively high surface areas from 44 to 155 m(2) g(-1) after ionothermal processing, which can be significantly increased to > 350 m(2) g(-1) by further thermal treatment (e. g. post-carbonization at 750 degrees C). CO(2) and N(2) sorption analysis, combined with Hg intrusion porosimetry, reveals a promising hierarchical pore structuring to these carbon materials. The ionic liquid [Bmim][FeCl(4)] has a triple role: it acts as both a soft template to generate the characterized pore structuring, solvent and as a catalyst resulting in enhanced ionothermal carbon yields. Importantly from a process point of view, the ionic liquid can be successfully recovered and reused. The current work shows that ionothermal synthesis has the potential to be an effective, low cost, and green reusable synthetic route towards sustainable porous carbon materials.}, language = {en} } @misc{BaeumerRossbachMischkeetal.2011, author = {B{\"a}umer, Wolfgang and Rossbach, Kristine and Mischke, Reinhard and Reines, Ilka and Langbein-Detsch, Ines and L{\"u}th, Anja and Kleuser, Burkhard}, title = {Decreased concentration and enhanced metabolism of sphingosine-1-Phosphate in lesional skin of dogs with atopic dermatitis disturbed Sphingosine-1-Phosphate homeostasis in atopic Dermatitis}, series = {The journal of investigative dermatology}, volume = {131}, journal = {The journal of investigative dermatology}, number = {1}, publisher = {Nature Publ. Group}, address = {New York}, issn = {0022-202X}, doi = {10.1038/jid.2010.252}, pages = {266 -- 268}, year = {2011}, language = {en} } @article{SchluneggerNortonZeilinger2011, author = {Schlunegger, Fritz and Norton, Kevin P. and Zeilinger, Gerold}, title = {Climatic forcing on channel profiles in the eastern cordillera of the Coroico Region, Bolivia}, series = {The journal of geology}, volume = {119}, journal = {The journal of geology}, number = {1}, publisher = {Univ. of Chicago Press}, address = {Chicago}, issn = {0022-1376}, doi = {10.1086/657407}, pages = {97 -- 107}, year = {2011}, abstract = {Orographic precipitation has a large impact on channel morphology and rock uplift via a positive feedback to erosion. We show that in the Eastern Cordillera of Bolivia, channel concavities reach their highest values where annual precipitation increases in the downstream direction, exceeding 3000 mm. The steepest channels are upstream of this zone of high concavity, where precipitation rates are <1000 mm yr(-1). Channels exhibit graded forms both upstream and downstream of this transient reach. We conclude that the prolonged effect of orographic erosion and related tectonic uplift is the preservation of channels with extreme concavities in the Eastern Cordillera.}, language = {en} } @article{PitzerJennenSteinmetzEsseretal.2011, author = {Pitzer, Martina and Jennen-Steinmetz, Christine and Esser, G{\"u}nter and Schmidt, Martin H. and Laucht, Manfred}, title = {Prediction of preadolescent depressive symptoms from child temperament, maternal distress, and gender results of a prospective, longitudinal study}, series = {Journal of developmental and behavioral pediatrics}, volume = {32}, journal = {Journal of developmental and behavioral pediatrics}, number = {1}, publisher = {Lippincott Williams \& Wilkins}, address = {Philadelphia}, issn = {0196-206X}, doi = {10.1097/DBP.0b013e3181f4a474}, pages = {18 -- 26}, year = {2011}, abstract = {Objective: The delineation of developmental pathways to juvenile depressive symptoms is of major clinical interest because these are known to be predictive for adult mood disorders and for a range of other mental health problems. This study investigates the impact of child temperament and early maternal distress, both of which are known to influence children's emotional development, on preadolescent depression. Methods: In a prospective, longitudinal at-risk sample (163 boys, 178 girls), we assessed temperament at the age of 3 months and at 2 years, 4.5 years, and 8 years, respectively, and chronic maternal distress during infancy. Hierarchical linear regression analysis was used to investigate the prediction of depressive symptoms at the age of 11 years measured by the Child Depression Inventory. In addition, we controlled for psychosocial and obstetric perinatal risks and gender. Results: Psychosocial risks and self-control temperament made significant independent contributions to preadolescent depression, whereas fearful, difficult temperament and obstetric risks were unrelated to depressive outcome. Interestingly, a clear gender difference emerged with a significant prediction from maternal distress only in girls. Conclusions: Our data extend previous findings of a concurrent association between regulative temperament and juvenile depression to a predictive view. Furthermore, the results point toward gender-specific pathways to preadolescent depression and support earlier findings indicating that subclinical maternal distress may exert as detrimental effects on child development as clinical depression.}, language = {en} } @article{CatchpolePlatzerWeikertetal.2011, author = {Catchpole, Gareth and Platzer, Alexander and Weikert, Cornelia and Kempkensteffen, Carsten and Johannsen, Manfred and Krause, Hans and Jung, Klaus and Miller, Kurt and Willmitzer, Lothar and Selbig, Joachim and Weikert, Steffen}, title = {Metabolic profiling reveals key metabolic features of renal cell carcinoma}, series = {Journal of cellular and molecular medicine : a journal of translational medicine}, volume = {15}, journal = {Journal of cellular and molecular medicine : a journal of translational medicine}, number = {1}, publisher = {Wiley-Blackwell}, address = {Malden}, issn = {1582-1838}, doi = {10.1111/j.1582-4934.2009.00939.x}, pages = {109 -- 118}, year = {2011}, abstract = {Recent evidence suggests that metabolic changes play a pivotal role in the biology of cancer and in particular renal cell carcinoma (RCC). Here, a global metabolite profiling approach was applied to characterize the metabolite pool of RCC and normal renal tissue. Advanced decision tree models were applied to characterize the metabolic signature of RCC and to explore features of metastasized tumours. The findings were validated in a second independent dataset. Vitamin E derivates and metabolites of glucose, fatty acid, and inositol phosphate metabolism determined the metabolic profile of RCC. alpha-tocopherol, hippuric acid, myoinositol, fructose-1-phosphate and glucose-1-phosphate contributed most to the tumour/normal discrimination and all showed pronounced concentration changes in RCC. The identified metabolic profile was characterized by a low recognition error of only 5\% for tumour versus normal samples. Data on metastasized tumours suggested a key role for metabolic pathways involving arachidonic acid, free fatty acids, proline, uracil and the tricarboxylic acid cycle. These results illustrate the potential of mass spectroscopy based metabolomics in conjunction with sophisticated data analysis methods to uncover the metabolic phenotype of cancer. Differentially regulated metabolites, such as vitamin E compounds, hippuric acid and myoinositol, provide leads for the characterization of novel pathways in RCC.}, language = {en} } @article{KrauseBuseMaternetal.2011, author = {Krause, Rolf Harald and Buse, Joern and Matern, Andrea and Schroeder, Boris and Haerdtle, Werner and Assmann, Thorsten}, title = {Eresus kollari (Araneae: Eresidae) calls for heathland management}, series = {The Journal of arachnology}, volume = {39}, journal = {The Journal of arachnology}, number = {3}, publisher = {American Arachnological Society}, address = {College Park}, issn = {0161-8202}, pages = {384 -- 392}, year = {2011}, abstract = {Northwest Europe's largest heather-dominated sandy habitats are located in the nature reserve Luneburger Heide, Germany. Yet, even these appear to be losing their ability to support some of their stenotopic species such as the ladybird spider, Eresus kollari Rossi 1846, and are thus becoming increasingly important for the preservation of these species. The habitat requirements of this endangered spider species were investigated in order to obtain data that will help stabilize the last remnants of the species' population in northwest Germany. Several heathland habitats were surveyed by pitfall trapping during the mate-search period of the males. Two statistical methods were applied: logistic regression and boosted regression trees (BRT). Both methods showed that three habitat variables are of prime relevance in predicting the occurrence of E. kollari: a) thickness of the organic layer (a negative effect), b) soil temperature at a depth of 10 cm, and c) Calluna cover in the herb layer (both have positive effect). Our results show that choppering (removing above-ground biomass and most of O-layer) and burning are likely appropriate heathland management measures for the conservation of E. kollari. Such measures improve the species' habitat quality by creating a heterogenic (small-scaled) heathland structure with suitable microhabitats. As Calluna heathlands show a clear senescence of the dominant heather, it is essential that those habitat patches be conserved. Further measures, such as transfer experiments, are recommended.}, language = {en} } @article{MuellerMayerBauretal.2011, author = {M{\"u}ller, Steffen and Mayer, Patrizia and Baur, Heiner and Mayer, Frank}, title = {Higher velocities in isokinetic dynamometry a pilot study of new test mode with active compensation of inertia}, series = {Isokinetics and exercise science : official journal of the European Isokinetic Society}, volume = {19}, journal = {Isokinetics and exercise science : official journal of the European Isokinetic Society}, number = {2}, publisher = {IOS Press}, address = {Amsterdam}, issn = {0959-3020}, doi = {10.3233/IES-2011-0398}, pages = {63 -- 70}, year = {2011}, abstract = {Isokinetic dynamometry is a standard technique for strength testing and training. Nevertheless reliability and validity is limited due to inertia effects, especially for high velocities. Therefore in a first methodological approach the purpose was to evaluate a new isokinetic measurement mode including inertia compensation compared to a classic isokinetic measurement mode for single and multijoint movements at different velocities. Isokinetic maximum strength measurements were carried out in 26 healthy active subjects. Tests were performed using classic isokinetic and new isokinetic mode in random order. Maximum torque/force, maximum movement velocity and time for acceleration were calculated. For inter-instrument agreement Bland and Altman analysis, systematic and random error was quantified. Differences between both methods were assessed (ANOVA alpha = 0.05). Bland and Altman analysis showed the highest agreement between the two modes for strength and velocity measurements (bias: < +/- 1.1\%; LOA: < 14.2\%) in knee flexion/extension at slow isokinetic velocity (60 degrees/s). Least agreement (range: bias: -67.6\% +/- 119.0\%; LOA: 53.4\% 69.3\%) was observed for shoulder/arm test at high isokinetic velocity (360 degrees/s). The Isokin(new) mode showed higher maximum movement velocities (p < 0.05). For low isokinetic velocities the new mode agrees with the classic mode. Especially at high isokinetic velocities the new isokinetic mode shows relevant benefits coupled with a possible trade-off with the force/torque measurement. In conclusion, this study offers for the first time a comparison between the 'classical' and inertia-compensated isokinetic dynamometers indicating the advantages and disadvantages associated with each individual approach, particularly as they relate to medium or high velocities in testing and training.}, language = {en} } @article{Gruene2011, author = {Gr{\"u}ne, Stefanie}, title = {Is there a Gap in Kant's B Deduction?}, series = {International journal of philosophical studies}, volume = {19}, journal = {International journal of philosophical studies}, number = {3}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0967-2559}, doi = {10.1080/09672559.2011.595196}, pages = {465 -- 490}, year = {2011}, abstract = {In 'Beyond the Myth of the Myth: A Kantian Theory of Non-Conceptual Content', Robert Hanna argues for a very strong kind of non-conceptualism, and claims that this kind of non-conceptualism originally has been developed by Kant. But according to 'Kant's Non-Conceptualism, Rogue Objects and the Gap in the B Deduction', Kant's non-conceptualism poses a serious problem for his argument for the objective validity of the categories, namely the problem that there is a gap in the B Deduction. This gap is that the B Deduction goes through only if conceptualism is true, but Kant is a non-conceptualist. In this paper, I will argue, contrary to what Hanna claims, that there is not a gap in the B Deduction.}, language = {en} } @inproceedings{LauchtBlomeyerElFaddaghetal.2011, author = {Laucht, Manfred and Blomeyer, Dorothea and El-Faddagh, Mahha and Esser, G{\"u}nter and Schmidt, Martin and Banaschewski, Tobias and Becker, Katja}, title = {Are regulatory problems in infancy precursors of ADHD in childhood? a moderating role for the dopamine D4 receptor gene}, series = {Infant mental health journal}, volume = {32}, booktitle = {Infant mental health journal}, number = {3}, publisher = {Wiley-Blackwell}, address = {Hoboken}, issn = {0163-9641}, pages = {212 -- 212}, year = {2011}, language = {en} } @article{RiveraVillarreyesBaroniOswald2011, author = {Rivera Villarreyes, C. A. and Baroni, Gabriele and Oswald, Sascha}, title = {Integral quantification of seasonal soil moisture changes in farmland by cosmic-ray neutrons}, series = {Hydrology and earth system sciences : HESS}, volume = {15}, journal = {Hydrology and earth system sciences : HESS}, number = {12}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1027-5606}, doi = {10.5194/hess-15-3843-2011}, pages = {3843 -- 3859}, year = {2011}, abstract = {Soil moisture at the plot or hill-slope scale is an important link between local vadose zone hydrology and catchment hydrology. However, so far only a few methods are on the way to close this gap between point measurements and remote sensing. One new measurement methodology that could determine integral soil moisture at this scale is the aboveground sensing of cosmic-ray neutrons, more precisely of ground albedo neutrons. The present study performed ground albedo neutron sensing (GANS) at an agricultural field in northern Germany. To test the method it was accompanied by other soil moisture measurements for a summer period with corn crops growing on the field and a later autumn-winter period without crops and a longer period of snow cover. Additionally, meteorological data and aboveground crop biomass were included in the evaluation. Hourly values of ground albedo neutron sensing showed a high statistical variability. Six-hourly values corresponded well with classical soil moisture measurements, after calibration based on one reference dry period and three wet periods of a few days each. Crop biomass seemed to influence the measurements only to minor degree, opposed to snow cover which has a more substantial impact on the measurements. The latter could be quantitatively related to a newly introduced field neutron ratio estimated from neutron counting rates of two energy ranges. Overall, our study outlines a procedure to apply the ground albedo neutron sensing method based on devices now commercially available, without the need for accompanying numerical simulations and suited for longer monitoring periods after initial calibration.}, language = {en} } @article{MunzOswaldSchmidt2011, author = {Munz, Matthias and Oswald, Sascha and Schmidt, C.}, title = {Sand box experiments to evaluate the influence of subsurface temperature probe design on temperature based water flux calculation}, series = {Hydrology and earth system sciences : HESS}, volume = {15}, journal = {Hydrology and earth system sciences : HESS}, number = {11}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1027-5606}, doi = {10.5194/hess-15-3495-2011}, pages = {3495 -- 3510}, year = {2011}, abstract = {Quantification of subsurface water fluxes based on the one dimensional solution to the heat transport equation depends on the accuracy of measured subsurface temperatures. The influence of temperature probe setup on the accuracy of vertical water flux calculation was systematically evaluated in this experimental study. Four temperature probe setups were installed into a sand box experiment to measure temporal highly resolved vertical temperature profiles under controlled water fluxes in the range of +/- 1.3 md(-1). Pass band filtering provided amplitude differences and phase shifts of the diurnal temperature signal varying with depth depending on water flux. Amplitude ratios of setups directly installed into the saturated sediment significantly varied with sand box hydraulic gradients. Amplitude ratios provided an accurate basis for the analytical calculation of water flow velocities, which matched measured flow velocities. Calculated flow velocities were sensitive to thermal properties of saturated sediment and to temperature sensor spacing, but insensitive to thermal dispersivity equal to solute dispersivity. Amplitude ratios of temperature probe setups indirectly installed into piezometer pipes were influenced by thermal exchange processes within the pipes and significantly varied with water flux direction only. Temperature time lags of small sensor distances of all setups were found to be insensitive to vertical water flux.}, language = {en} } @article{FaderGertenThammeretal.2011, author = {Fader, Marianelle and Gerten, Dieter and Thammer, M. and Heinke, J. and Lotze-Campen, Hermann and Lucht, Wolfgang and Cramer, Wolfgang}, title = {Internal and external green-blue agricultural water footprints of nations, and related water and land savings through trade}, series = {Hydrology and earth system sciences : HESS}, volume = {15}, journal = {Hydrology and earth system sciences : HESS}, number = {5}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1027-5606}, doi = {10.5194/hess-15-1641-2011}, pages = {1641 -- 1660}, year = {2011}, abstract = {The need to increase food production for a growing world population makes an assessment of global agricultural water productivities and virtual water flows important. Using the hydrology and agro-biosphere model LPJmL, we quantify at 0.5 degrees resolution the amount of blue and green water (irrigation and precipitation water) needed to produce one unit of crop yield, for 11 of the world's major crop types. Based on these, we also quantify the agricultural water footprints (WFP) of all countries, for the period 1998-2002, distinguishing internal and external WFP (virtual water imported from other countries) and their blue and green components, respectively. Moreover, we calculate water savings and losses, and for the first time also land savings and losses, through international trade with these products. The consistent separation of blue and green water flows and footprints shows that green water globally dominates both the internal and external WFP (84\% of the global WFP and 94\% of the external WFP rely on green water). While no country ranks among the top ten with respect to all water footprints calculated here, Pakistan and Iran demonstrate high absolute and per capita blue WFP, and the US and India demonstrate high absolute green and blue WFPs. The external WFPs are relatively small (6\% of the total global blue WFP, 16\% of the total global green WFP). Nevertheless, current trade of the products considered here saves significant water volumes and land areas (similar to 263 km(3) and similar to 41 Mha, respectively, equivalent to 5\% of the sowing area of the considered crops and 3.5\% of the annual precipitation on this area). Relating the proportions of external to internal blue/green WFP to the per capita WFPs allows recognizing that only a few countries consume more water from abroad than from their own territory and have at the same time above-average WFPs. Thus, countries with high per capita water consumption affect mainly the water availability in their own country. Finally, this study finds that flows/savings of both virtual water and virtual land need to be analysed together, since they are intrinsically related.}, language = {en} } @article{BallatoUbaLandgrafetal.2011, author = {Ballato, Paolo and Uba, Cornelius Eji and Landgraf, Angela and Strecker, Manfred and Sudo, Masafumi and Stockli, Daniel F. and Friedrich, Anke M. and Tabatabaei, Saeid H.}, title = {Arabia-Eurasia continental collision insights from late Tertiary foreland-basin evolution in the Alborz Mountains, northern Iran}, series = {Geological Society of America bulletin}, volume = {123}, journal = {Geological Society of America bulletin}, number = {1-2}, publisher = {American Institute of Physics}, address = {Boulder}, issn = {0016-7606}, doi = {10.1130/B30091.1}, pages = {106 -- 131}, year = {2011}, abstract = {A poorly understood lag time of 15-20 m.y. exists between the initial Arabia-Eurasia continental collision in late Eocene to early Oligocene time and the acceleration of tectonic and sedimentary processes across the collision zone in the early to late Miocene. The late Eocene to Miocene-Pliocene clastic and shallow-marine sedimentary rocks of the Kond, Eyvanekey, and Semnan Basins in the Alborz Mountains (northern Iran) offer the possibility to track the evolution of this orogen in the framework of collision processes. A transition from volcaniclastic submarine deposits to shallow-marine evaporites and terrestrial sediments occurred shortly after 36 Ma in association with reversals in sediment provenance, strata tilting, and erosional unroofing. These events followed the termination of subduction arc magmatism and marked a changeover from an extensional to a contractional regime in response to initiation of continental collision with the subduction of stretched Arabian lithosphere. This early stage of collision produced topographic relief associated with shallow foreland basins, suggesting that shortening and tectonic loading occurred at low rates. Starting from the early Miocene (17.5 Ma), flexural subsidence in response to foreland basin initiation occurred. Fast sediment accumulation rates and erosional unroofing trends point to acceleration of shortening by the early Miocene. We suggest that the lag time between the initiation of continental collision (36 Ma) and the acceleration of regional deformation (20-17.5 Ma) reflects a two-stage collision process, involving the "soft" collision of stretched lithosphere at first and "hard" collision following the arrival of unstretched Arabian continental litho sphere in the subduction zone.}, language = {en} } @article{LaiDentonGilesMuellerRoeberetal.2011, author = {Lai, Alvina G. and Denton-Giles, Matthew and M{\"u}ller-R{\"o}ber, Bernd and Schippers, Jos H. M. and Dijkwel, Paul P.}, title = {Positional information resolves structural variations and uncovers an evolutionarily divergent genetic locus in accessions of arabidopsis thaliana}, series = {Genome biology and evolution}, volume = {3}, journal = {Genome biology and evolution}, number = {1-2}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {1759-6653}, doi = {10.1093/gbe/evr038}, pages = {627 -- 640}, year = {2011}, abstract = {Genome sequencing of closely related individuals has yielded valuable insights that link genome evolution to phenotypic variations. However, advancement in sequencing technology has also led to an escalation in the number of poor quality-drafted genomes assembled based on reference genomes that can have highly divergent or haplotypic regions. The self-fertilizing nature of Arabidopsis thaliana poses an advantage to sequencing projects because its genome is mostly homozygous. To determine the accuracy of an Arabidopsis drafted genome in less conserved regions, we performed a resequencing experiment on a similar to 371-kb genomic interval in the Landsberg erecta (Ler-0) accession. We identified novel structural variations (SVs) between Ler-0 and the reference accession Col-0 using a long-range polymerase chain reaction approach to generate an Illumina data set that has positional information, that is, a data set with reads that map to a known location. Positional information is important for accurate genome assembly and the resolution of SVs particularly in highly duplicated or repetitive regions. Sixty-one regions with misassembly signatures were identified from the Ler-0 draft, suggesting the presence of novel SVs that are not represented in the draft sequence. Sixty of those were resolved by iterative mapping using our data set. Fifteen large indels (> 100 bp) identified from this study were found to be located either within protein-coding regions or upstream regulatory regions, suggesting the formation of novel alleles or altered regulation of existing genes in Ler-0. We propose future genome-sequencing experiments to follow a clone-based approach that incorporates positional information to ultimately reveal haplotype-specific differences between accessions.}, language = {en} } @article{WeidlichPolyvyanyyMendlingetal.2011, author = {Weidlich, Matthias and Polyvyanyy, Artem and Mendling, Jan and Weske, Mathias}, title = {Causal behavioural profiles - efficient computation, applications, and evaluation}, series = {Fundamenta informaticae}, volume = {113}, journal = {Fundamenta informaticae}, number = {3-4}, publisher = {IOS Press}, address = {Amsterdam}, issn = {0169-2968}, doi = {10.3233/FI-2011-614}, pages = {399 -- 435}, year = {2011}, abstract = {Analysis of behavioural consistency is an important aspect of software engineering. In process and service management, consistency verification of behavioural models has manifold applications. For instance, a business process model used as system specification and a corresponding workflow model used as implementation have to be consistent. Another example would be the analysis to what degree a process log of executed business operations is consistent with the corresponding normative process model. Typically, existing notions of behaviour equivalence, such as bisimulation and trace equivalence, are applied as consistency notions. Still, these notions are exponential in computation and yield a Boolean result. In many cases, however, a quantification of behavioural deviation is needed along with concepts to isolate the source of deviation. In this article, we propose causal behavioural profiles as the basis for a consistency notion. These profiles capture essential behavioural information, such as order, exclusiveness, and causality between pairs of activities of a process model. Consistency based on these profiles is weaker than trace equivalence, but can be computed efficiently for a broad class of models. In this article, we introduce techniques for the computation of causal behavioural profiles using structural decomposition techniques for sound free-choice workflow systems if unstructured net fragments are acyclic or can be traced back to S-or T-nets. We also elaborate on the findings of applying our technique to three industry model collections.}, language = {en} } @article{CiliaLandwehrPasserini2011, author = {Cilia, Elisa and Landwehr, Niels and Passerini, Andrea}, title = {Relational feature mining with hierarchical multitask kFOIL}, series = {Fundamenta informaticae}, volume = {113}, journal = {Fundamenta informaticae}, number = {2}, publisher = {IOS Press}, address = {Amsterdam}, issn = {0169-2968}, doi = {10.3233/FI-2011-604}, pages = {151 -- 177}, year = {2011}, abstract = {We introduce hierarchical kFOIL as a simple extension of the multitask kFOIL learning algorithm. The algorithm first learns a core logic representation common to all tasks, and then refines it by specialization on a per-task basis. The approach can be easily generalized to a deeper hierarchy of tasks. A task clustering algorithm is also proposed in order to automatically generate the task hierarchy. The approach is validated on problems of drug-resistance mutation prediction and protein structural classification. Experimental results show the advantage of the hierarchical version over both single and multi task alternatives and its potential usefulness in providing explanatory features for the domain. Task clustering allows to further improve performance when a deeper hierarchy is considered.}, language = {en} } @article{TelkemeyerRossiNierhausetal.2011, author = {Telkemeyer, Silke and Rossi, Sonja and Nierhaus, Till and Steinbrink, Jens and Obrig, Hellmuth and Wartenburger, Isabell}, title = {Acoustic processing of temporally modulated sounds in infants evidence from a combined near-infrared spectroscopy and EEG study}, series = {Frontiers in psychology}, volume = {2}, journal = {Frontiers in psychology}, number = {2}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2011.00062}, pages = {14}, year = {2011}, abstract = {Speech perception requires rapid extraction of the linguistic content from the acoustic signal. The ability to efficiently process rapid changes in auditory information is important for decoding speech and thereby crucial during language acquisition. Investigating functional networks of speech perception in infancy might elucidate neuronal ensembles supporting perceptual abilities that gate language acquisition. Interhemispheric specializations for language have been demonstrated in infants. How these asymmetries are shaped by basic temporal acoustic properties is under debate. We recently provided evidence that newborns process non-linguistic sounds sharing temporal features with language in a differential and lateralized fashion. The present study used the same material while measuring brain responses of 6 and 3 month old infants using simultaneous recordings of electroencephalography (EEG) and near-infrared spectroscopy (NIRS). NIRS reveals that the lateralization observed in newborns remains constant over the first months of life. While fast acoustic modulations elicit bilateral neuronal activations, slow modulations lead to right-lateralized responses. Additionally, auditory-evoked potentials and oscillatory EEG responses show differential responses for fast and slow modulations indicating a sensitivity for temporal acoustic variations. Oscillatory responses reveal an effect of development, that is, 6 but not 3 month old infants show stronger theta-band desynchronization for slowly modulated sounds. Whether this developmental effect is due to increasing fine-grained perception for spectrotemporal sounds in general remains speculative. Our findings support the notion that a more general specialization for acoustic properties can be considered the basis for lateralization of speech perception. The results show that concurrent assessment of vascular based imaging and electrophysiological responses have great potential in the research on language acquisition.}, language = {en} } @article{KlieglWeiDambacheretal.2011, author = {Kliegl, Reinhold and Wei, Ping and Dambacher, Michael and Yan, Ming and Zhou, Xiaolin}, title = {Experimental effects and individual differences in linear mixed models estimating the relationship between spatial, object, and attraction effects in visual attention}, series = {Frontiers in psychology}, volume = {2}, journal = {Frontiers in psychology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2010.00238}, pages = {12}, year = {2011}, abstract = {Linear mixed models (LMMs) provide a still underused methodological perspective on combining experimental and individual-differences research. Here we illustrate this approach with two-rectangle cueing in visual attention (Egly et al., 1994). We replicated previous experimental cue-validity effects relating to a spatial shift of attention within an object (spatial effect), to attention switch between objects (object effect), and to the attraction of attention toward the display centroid (attraction effect), also taking into account the design-inherent imbalance of valid and other trials. We simultaneously estimated variance/covariance components of subject-related random effects for these spatial, object, and attraction effects in addition to their mean reaction times (RTs). The spatial effect showed a strong positive correlation with mean RT and a strong negative correlation with the attraction effect. The analysis of individual differences suggests that slow subjects engage attention more strongly at the cued location than fast subjects. We compare this joint LMM analysis of experimental effects and associated subject-related variances and correlations with two frequently used alternative statistical procedures.}, language = {en} } @misc{FischerBrugger2011, author = {Fischer, Martin H. and Brugger, Peter}, title = {When digits help digits spatial-numerical associations point to finger counting as prime example of embodied cognition}, series = {Frontiers in psychology}, volume = {2}, journal = {Frontiers in psychology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2011.00260}, pages = {7}, year = {2011}, abstract = {Spatial numerical associations (SNAs) are prevalent yet their origin is poorly understood. We first consider the possible prime role of reading habits in shaping SNAs and list three observations that argue against a prominent influence of this role: (1) directional reading habits for numbers may conflict with those for non-numerical symbols, (2) short-term experimental manipulations can overrule the impact of decades of reading experience, (3) SNAs predate the acquisition of reading. As a promising alternative, we discuss behavioral, neuroscientific, and neuropsychological evidence in support of finger counting as the most likely initial determinant of SNAs. Implications of this "manumerical cognition" stance for the distinction between grounded, embodied, and situated cognition are discussed.}, language = {en} }