@misc{Quaisser1992, author = {Quaisser, Erhard}, title = {Zeitler, H., Mathematische Semesterberichte, 39 (1992), S. 163 - 183}, year = {1992}, language = {de} } @misc{Quaisser1992, author = {Quaisser, Erhard}, title = {Woodall, D., Geombinatorics, 1 (1992), 4, S. 18 - 20}, year = {1992}, language = {de} } @misc{Klotzek1995, author = {Klotzek, Benno}, title = {Vermes, I., {\"U}ber die synthetische Behandlung der Kr{\"u}mmung und des Schmiegzykels der ebenen Kurven in der Bolyai-Lobatschefskyschen Geometrie}, year = {1995}, language = {de} } @misc{WeisserStueblerMatheisetal.2017, author = {Weisser, Karin and St{\"u}bler, Sabine and Matheis, Walter and Huisinga, Wilhelm}, title = {Towards toxicokinetic modelling of aluminium exposure from adjuvants in medicinal products}, series = {Regulatory toxicology and pharmacology : official journal of the International Society for Regulatory Toxicology and Pharmacology}, volume = {88}, journal = {Regulatory toxicology and pharmacology : official journal of the International Society for Regulatory Toxicology and Pharmacology}, publisher = {Elsevier}, address = {San Diego}, issn = {0273-2300}, doi = {10.1016/j.yrtph.2017.02.018}, pages = {310 -- 321}, year = {2017}, abstract = {As a potentially toxic agent on nervous system and bone, the safety of aluminium exposure from adjuvants in vaccines and subcutaneous immune therapy (SCIT) products has to be continuously reevaluated, especially regarding concomitant administrations. For this purpose, knowledge on absorption and disposition of aluminium in plasma and tissues is essential. Pharmacokinetic data after vaccination in humans, however, are not available, and for methodological and ethical reasons difficult to obtain. To overcome these limitations, we discuss the possibility of an in vitro-in silico approach combining a toxicokinetic model for aluminium disposition with biorelevant kinetic absorption parameters from adjuvants. We critically review available kinetic aluminium-26 data for model building and, on the basis of a reparameterized toxicokinetic model (Nolte et al., 2001), we identify main modelling gaps. The potential of in vitro dissolution experiments for the prediction of intramuscular absorption kinetics of aluminium after vaccination is explored. It becomes apparent that there is need for detailed in vitro dissolution and in vivo absorption data to establish an in vitro-in vivo correlation (IVIVC) for aluminium adjuvants. We conclude that a combination of new experimental data and further refinement of the Nolte model has the potential to fill a gap in aluminium risk assessment. (C) 2017 Elsevier Inc. All rights reserved.}, language = {en} } @misc{PfaeffleStephan2012, author = {Pf{\"a}ffle, Frank and Stephan, Christoph A.}, title = {The holst action by the spectral action principle (vol 307, pg 261, 2011)}, series = {Communications in mathematical physics}, volume = {313}, journal = {Communications in mathematical physics}, number = {1}, publisher = {Springer}, address = {New York}, issn = {0010-3616}, doi = {10.1007/s00220-012-1507-y}, pages = {291 -- 292}, year = {2012}, language = {en} } @misc{WichaKeesSolmsetal.2015, author = {Wicha, Sebastian G. and Kees, Martin G. and Solms, Alexander Maximilian and Minichmayr, Iris K. and Kratzer, Alexander and Kloft, Charlotte}, title = {TDMx: A novel web-based open-access support tool for optimising antimicrobial dosing regimens in clinical routine}, series = {International journal of antimicrobial agents}, volume = {45}, journal = {International journal of antimicrobial agents}, number = {4}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0924-8579}, doi = {10.1016/j.ijantimicag.2014.12.010}, pages = {442 -- 444}, year = {2015}, language = {en} } @misc{Klotzek1994, author = {Klotzek, Benno}, title = {St{\"a}rk, R., Beispiele zur Anwendung eines Computeralgebrasystems in der Geometrie}, year = {1994}, language = {de} } @misc{Quaisser1993, author = {Quaisser, Erhard}, title = {Strambach, K., Centro Stampa Univ. degli Studi di Perugia, (1993), S. 21 - 24}, year = {1993}, language = {it} } @misc{Quaisser1993, author = {Quaisser, Erhard}, title = {Steinke, G. F., Geometriae Dedicata, 48 (1993), S. 337 - 348}, year = {1993}, language = {de} } @misc{Klotzek1994, author = {Klotzek, Benno}, title = {Stammler, L., Einige Themen im Zusammenhang mit rasterbezogenem Approximieren}, year = {1994}, language = {de} } @misc{Quaisser1996, author = {Quaisser, Erhard}, title = {Siciliano, A., J. Geom., 55 (1996), S. 162 - 167}, year = {1996}, language = {de} } @misc{Klotzek1996, author = {Klotzek, Benno}, title = {R{\"o}schel, O., Drehfl{\"a}chen zweiter Ordnung durch einen Kegelschnitt}, year = {1996}, language = {de} } @misc{Klotzek1995, author = {Klotzek, Benno}, title = {Ruegg, A. ; Burmeister, G., M{\´e}thodes constructives de la g{\´e}om{\´e}trie spatiale}, year = {1995}, language = {fr} } @misc{Quaisser1996, author = {Quaisser, Erhard}, title = {Rosenfeld, M., Geombinatorics, 5 (1996), 4, S. 156 - 159}, year = {1996}, language = {de} } @misc{ZoellerHolschneider2018, author = {Z{\"o}ller, Gert and Holschneider, Matthias}, title = {Reply to "Comment on 'The Maximum Possible and the Maximum Expected Earthquake Magnitude for Production-Induced Earthquakes at the Gas Field in Groningen, The Netherlands' by Gert Z{\"o}ller and Matthias Holschneider" by Mathias Raschke}, series = {Bulletin of the Seismological Society of America}, volume = {108}, journal = {Bulletin of the Seismological Society of America}, number = {2}, publisher = {Seismological Society of America}, address = {Albany}, issn = {0037-1106}, doi = {10.1785/0120170131}, pages = {1029 -- 1030}, year = {2018}, language = {en} } @misc{OsterlohaBoeckmannNicolaeetal.2014, author = {Osterloha, Lukas and B{\"o}ckmann, Christine and Nicolae, Doina and Nemuc, Anca}, title = {Regularized inversion of microphysical atmospheric particle parameters: Theory and application (vol 237, pg 79, 2013)}, series = {Journal of computational physics}, volume = {275}, journal = {Journal of computational physics}, publisher = {Elsevier}, address = {San Diego}, issn = {0021-9991}, doi = {10.1016/j.jcp.2014.07.041}, pages = {696 -- 696}, year = {2014}, language = {en} } @misc{Quaisser1995, author = {Quaisser, Erhard}, title = {Quan, L., Journal of mathematical imaging and vision, 5 (1995), S. 263 - 267}, year = {1995}, language = {en} } @misc{Quaisser1995, author = {Quaisser, Erhard}, title = {Payne, S.R., Linear algebra appl., 226/228 (1995), S. 115 - 137}, year = {1995}, language = {en} } @misc{ButuzovNefedovReckeetal.2019, author = {Butuzov, Valentin F. and Nefedov, N. N. and Recke, Lutz and Omel'chenko, Oleh}, title = {Partly dissipative system with multizonal initial and boundary layers}, series = {Journal of Physics: Conference Series}, volume = {1205}, journal = {Journal of Physics: Conference Series}, publisher = {IOP Publ.}, address = {Bristol}, issn = {1742-6588}, doi = {10.1088/1742-6596/1205/1/012009}, pages = {7}, year = {2019}, abstract = {For a singularly perturbed parabolic - ODE system we construct the asymptotic expansion in the small parameter in the case, when the degenerate equation has a double root. Such systems, which are called partly dissipative reaction-diffusion systems, are used to model various natural processes, including the signal transmission along axons, solid combustion and the kinetics of some chemical reactions. It turns out that the algorithm of the construction of the boundary layer functions and the behavior of the solution in the boundary layers essentially differ from that ones in case of a simple root. The multizonal initial and boundary layers behaviour was stated.}, language = {en} } @misc{GrisicHuisingaReinischetal.2017, author = {Grisic, Ana-Marija and Huisinga, Wilhelm and Reinisch, W. and Kloft, Charlotte}, title = {P485 Dosing infliximab in Crohn's disease}, series = {Journal of Crohn's and Colitis}, volume = {11}, journal = {Journal of Crohn's and Colitis}, number = {1}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {1873-9946}, doi = {10.1093/ecco-jcc/jjx002.609}, pages = {S325 -- S326}, year = {2017}, abstract = {Background: Infliximab (IFX), an anti-TNF monoclonal antibody approved for the treatment of inflammatory bowel disease, is dosed per kg body weight (BW). However, the rationale for body size adjustment has not been unequivocally demonstrated [1], and first attempts to improve IFX therapy have been undertaken [2]. The aim of our study was to assess the impact of different dosing strategies (i.e. body size-adjusted and fixed dosing) on drug exposure and pharmacokinetic (PK) target attainment. For this purpose, a comprehensive simulation study was performed, using patient characteristics (n=116) from an in-house clinical database. Methods: IFX concentration-time profiles of 1000 virtual, clinically representative patients were generated using a previously published PK model for IFX in patients with Crohn's disease [3]. For each patient 1000 profiles accounting for PK variability were considered. The IFX exposure during maintenance treatment after the following dosing strategies was compared: i) fixed dose, and per ii) BW, iii) lean BW (LBW), iv) body surface area (BSA), v) height (HT), vi) body mass index (BMI) and vii) fat-free mass (FFM)). For each dosing strategy the variability in maximum concentration Cmax, minimum concentration Cmin (= C8weeks) and area under the concentration-time curve (AUC), as well as percent of patients achieving the PK target, Cmin=3 μg/mL [4] were assessed. Results: For all dosing strategies the variability of Cmin (CV ≈110\%) was highest, compared to Cmax and AUC, and was of similar extent regardless of dosing strategy. The proportion of patients reaching the PK target (≈⅓ was approximately equal for all dosing strategies.}, language = {en} }