@misc{BaeumerRossbachMischkeetal.2011,
  author    = {B{\"a}umer, Wolfgang and Rossbach, Kristine and Mischke, Reinhard and Reines, Ilka and Langbein-Detsch, Ines and L{\"u}th, Anja and Kleuser, Burkhard},
  title     = {Decreased concentration and enhanced metabolism of sphingosine-1-Phosphate in lesional skin of dogs with atopic dermatitis disturbed Sphingosine-1-Phosphate homeostasis in atopic Dermatitis},
  series = {The journal of investigative dermatology},
  volume    = {131},
  journal   = {The journal of investigative dermatology},
  number    = {1},
  publisher = {Nature Publ. Group},
  address   = {New York},
  issn      = {0022-202X},
  doi       = {10.1038/jid.2010.252},
  pages     = {266 -- 268},
  year      = {2011},
  language  = {en}
}
@misc{PolzinRassafBoehmetal.2013,
  author    = {Polzin, Amin and Rassaf, Tienush and Boehm, Andreas and Lueth, Anja and Kleuser, Burkhard and Zeus, Tobias and Kelm, Malte and Kroemer, Heyo K. and Schroer, Karsten and Rauch, Bernhard H.},
  title     = {Aspirin inhibits release of platelet-derived sphingosine-1-phosphate in acute myocardial infarction},
  series = {INTERNATIONAL JOURNAL OF CARDIOLOGY},
  volume    = {170},
  journal   = {INTERNATIONAL JOURNAL OF CARDIOLOGY},
  number    = {2},
  publisher = {ELSEVIER IRELAND LTD},
  address   = {CLARE},
  issn      = {0167-5273},
  doi       = {10.1016/j.ijcard.2013.10.050},
  pages     = {E23 -- E24},
  year      = {2013},
  language  = {en}
}
@misc{HollmannReuterWerneretal.2016,
  author    = {Hollmann, C. and Reuter, D. and Werner, S. and Avota, Elita and Mueller, N. and Japtok, Lukasz and Kleuser, Burkhard and Becker, Katrin Anne and Gulbins, Erich and Schneider-Schaulies, J{\"u}rgen and Beyersdorf, Niklas},
  title     = {Pharmacological inhibition of acid sphingomyelinase or genetic ablation enhances CD4(+) Foxp3(+) regulatory T cell activity},
  series = {European journal of immunology},
  volume    = {46},
  journal   = {European journal of immunology},
  publisher = {Wiley-Blackwell},
  address   = {Hoboken},
  issn      = {0014-2980},
  pages     = {14 -- 14},
  year      = {2016},
  language  = {en}
}
@misc{NojimaKonishiJaptoketal.2016,
  author    = {Nojima, Hiroyuki and Konishi, Takanori and Japtok, Lukasz and Kleuser, Burkhard and Edwards, Michael J. and Gulbins, Erich and Lentsch, Alex B.},
  title     = {Chemokine receptors, CXCR1 and CXCR2, differentially regulate exosome release in hepatocytes},
  series = {Hepatology : official journal of the American Association for the Study of Liver Diseases},
  volume    = {64},
  journal   = {Hepatology : official journal of the American Association for the Study of Liver Diseases},
  publisher = {Wiley-Blackwell},
  address   = {Hoboken},
  issn      = {0270-9139},
  pages     = {165A -- 165A},
  year      = {2016},
  language  = {en}
}
@misc{DoegeHoenzkeSchumacheretal.2016,
  author    = {Doege, N. and Hoenzke, S. and Schumacher, Fabian and Balzus, Benjamin and Colombo, Miriam and Hadam, S. and Rancan, F. and Blume-Peytavi, Ulrike and Schindler, A. and Ruehl, E. and Skov, P. and Church, Martin K. and Hedtrich, Sarah and Kleuser, Burkhard and Bodmeier, Roland and Vogt, A.},
  title     = {Ex vivo microdialysis used for the preclinical assessment of anti-inflammatory therapy},
  series = {Experimental dermatology : the official journal of the European Immunodermatology Society},
  volume    = {25},
  journal   = {Experimental dermatology : the official journal of the European Immunodermatology Society},
  publisher = {Wiley-Blackwell},
  address   = {Hoboken},
  issn      = {0906-6705},
  pages     = {E32 -- E32},
  year      = {2016},
  language  = {en}
}
@misc{Kleuser2017,
  author    = {Kleuser, Burkhard},
  title     = {Medikamentennebenwirkungen auf Haut und Schleimhaut - allergische oder pharmakologisch erkl{\"a}rbare Reaktionen},
  series = {Allergologie},
  volume    = {40},
  journal   = {Allergologie},
  number    = {10},
  publisher = {Dustri-Verlag},
  address   = {Deisenhofen-M{\"u}nchen},
  issn      = {0344-5062},
  pages     = {420 -- 421},
  year      = {2017},
  language  = {de}
}
@misc{HalibasicFuerstHeidenetal.2017,
  author    = {Halibasic, Emina and Fuerst, Elisabeth and Heiden, Denis and Japtok, Lukasz and Diesner, Susanne C. and Hillebrand, P. and Trauner, Michael and Kleuser, Burkhard and Kazemi-Shirazi, Lili and Untersmayr, Eva},
  title     = {Significantly reduced plasma levels of the bioactive sphingolipid S1P in lung transplanted cystic fibrosis patients are associated with gastrointestinal symptoms},
  series = {Allergy},
  volume    = {72},
  journal   = {Allergy},
  number    = {S103},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {0105-4538},
  pages     = {195 -- 195},
  year      = {2017},
  language  = {en}
}
@misc{DoegeSchumacherBalzusetal.2017,
  author    = {D{\"o}ge, Nadine and Schumacher, Fabian and Balzus, Benjamin and Colombo, Miriam and Hadam, Sabrina and Rancan, Fiorenza and Blume-Peytavi, Ulrike and Kleuser, Burkhard and Bodmeier, Roland and Vogt, Annika},
  title     = {Particle- based formulations and controlled skin barrier disruption have a signifi cant impact on the delivery and penetration kinetics of dexamethasone as assessed in an ex vivo microdialysis},
  series = {Journal der Deutschen Dermatologischen Gesellschaft},
  volume    = {15},
  journal   = {Journal der Deutschen Dermatologischen Gesellschaft},
  publisher = {Wiley},
  address   = {Berlin},
  issn      = {1610-0379},
  pages     = {182 -- 182},
  year      = {2017},
  abstract  = {Preclinical assessment of penetration not only in intact, but also in barrier-disrupted skin is important to explore the surplus value of novel drug delivery systems, which can be specifically designed for diseased skin. Here, we characterized physical and chemical barrier disruption protocols for short-term ex vivo skin cultures with regard to structural integrity, physiological and biological parameters. Further, we compared the penetration of dexamethasone (Dex) in different nanoparticle-based formulations in stratum corneum, epidermis and dermis extracts of intact vs. barrier-disrupted skin as well as by dermal microdialysis at 6, 12 and 24 hours after topical application. Dex was quantified by liquid-chromatography - tandem-mass spectrometry (LC-MS/MS). Simultaneously, we investigated the Dex efficacy by interleukin (IL) analysis. Tape-stripping (TS) and 4 hours sodium lauryl sulfate 5 \% (SLS) exposure were identified as highly effective barrier disruption methods assessed by reproducible transepidermal water loss (TEWL) changes and IL-6/8 increase which was more pronounced in SLS-treated skin. The barrier state has also a significant impact on the Dex penetration kinetics: for all formulations, TS highly increased dermal Dex concentration despite the fact that nanocrystals quickly and effectively penetrated both, intact and barrier-disrupted skin reaching significantly higher dermal Dex concentration after 6 hours compared to Dex cream. The surplus value of encapsulation in ethyl cellulose nanocarriers could mostly be observed when applied on intact skin, in general showing a delayed Dex penetration. Estimation of cytokines was limited due to the trauma caused by probe insertion. In summary, ex vivo human skin is a highly interesting short-term preclinical model for the analysis of penetration and efficacy of novel drug delivery systems.},
  language  = {en}
}
@misc{PischonRadbruchOstrowskietal.2017,
  author    = {Pischon, Hannah and Radbruch, Moritz and Ostrowski, Anja and Schumacher, Fabian and Hoenzke, Stefan and Kleuser, Burkhard and Hedtrich, Sarah and Fluhr, Joachim W. and Gruber, Achim D. and Mundhenk, Lars},
  title     = {How Effective Is Tacrolimus in the Imiquimod},
  series = {The journal of investigative dermatology},
  volume    = {138},
  journal   = {The journal of investigative dermatology},
  number    = {2},
  publisher = {Elsevier},
  address   = {New York},
  issn      = {0022-202X},
  doi       = {10.1016/j.jid.2017.09.019},
  pages     = {455 -- 458},
  year      = {2017},
  language  = {en}
}
@misc{Kleuser2018,
  author    = {Kleuser, Burkhard},
  title     = {The enigma of sphingolipids in health and disease},
  series = {International journal of molecular sciences},
  volume    = {19},
  journal   = {International journal of molecular sciences},
  number    = {10},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1422-0067},
  doi       = {10.3390/ijms19103126},
  pages     = {3},
  year      = {2018},
  language  = {en}
}
@misc{SchwerbelKamitzJaehnertetal.2018,
  author    = {Schwerbel, Kristin and Kamitz, Anne and Jaehnert, Markus and Gottmann, P. and Schumacher, Fabian and Kleuser, Burkhard and Haltenhof, T. and Heyd, F. and Roden, Michael and Chadt, Alexandra and Al-Hasani, Hadi and Jonas, W. and Vogel, Heike and Sch{\"u}rmann, Annette},
  title     = {Two immune-related GTPases prevent from hepatic fat accumulation by inducing autophagy},
  series = {Diabetologia : journal of the European Association for the Study of Diabetes (EASD)},
  volume    = {61},
  journal   = {Diabetologia : journal of the European Association for the Study of Diabetes (EASD)},
  publisher = {Springer},
  address   = {New York},
  issn      = {0012-186X},
  pages     = {S259 -- S259},
  year      = {2018},
  language  = {en}
}