@phdthesis{Nikaj2019, author = {Nikaj, Adriatik}, title = {Restful choreographies}, doi = {10.25932/publishup-43890}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-438903}, school = {Universit{\"a}t Potsdam}, pages = {xix, 146}, year = {2019}, abstract = {Business process management has become a key instrument to organize work as many companies represent their operations in business process models. Recently, business process choreography diagrams have been introduced as part of the Business Process Model and Notation standard to represent interactions between business processes, run by different partners. When it comes to the interactions between services on the Web, Representational State Transfer (REST) is one of the primary architectural styles employed by web services today. Ideally, the RESTful interactions between participants should implement the interactions defined at the business choreography level. The problem, however, is the conceptual gap between the business process choreography diagrams and RESTful interactions. Choreography diagrams, on the one hand, are modeled from business domain experts with the purpose of capturing, communicating and, ideally, driving the business interactions. RESTful interactions, on the other hand, depend on RESTful interfaces that are designed by web engineers with the purpose of facilitating the interaction between participants on the internet. In most cases however, business domain experts are unaware of the technology behind web service interfaces and web engineers tend to overlook the overall business goals of web services. While there is considerable work on using process models during process implementation, there is little work on using choreography models to implement interactions between business processes. This thesis addresses this research gap by raising the following research question: How to close the conceptual gap between business process choreographies and RESTful interactions? This thesis offers several research contributions that jointly answer the research question. The main research contribution is the design of a language that captures RESTful interactions between participants---RESTful choreography modeling language. Formal completeness properties (with respect to REST) are introduced to validate its instances, called RESTful choreographies. A systematic semi-automatic method for deriving RESTful choreographies from business process choreographies is proposed. The method employs natural language processing techniques to translate business interactions into RESTful interactions. The effectiveness of the approach is shown by developing a prototypical tool that evaluates the derivation method over a large number of choreography models. In addition, the thesis proposes solutions towards implementing RESTful choreographies. In particular, two RESTful service specifications are introduced for aiding, respectively, the execution of choreographies' exclusive gateways and the guidance of RESTful interactions.}, language = {en} } @phdthesis{BarqueroPipin2019, author = {Barquero Pip{\´i}n, Antonio Carlos}, title = {Lengua, cultura, interculturalidad}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-480-7}, doi = {10.25932/publishup-43902}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-439023}, school = {Universit{\"a}t Potsdam}, pages = {429}, year = {2019}, abstract = {Ohne Pragmatik w{\"a}re Kommunikation nicht m{\"o}glich, da wir sprachliche Aussagen nicht interpretieren k{\"o}nnten. F{\"u}r jeden Lernenden einer Sprache, die er nicht beherrscht, reicht es nicht aus, sprachlich kompetent zu sein, da der Zweck der Kommunikation darin besteht, mit anderen Menschen und in bestimmten Kontexten zu kommunizieren. Nur eine Lehre, die es erm{\"o}glicht, Aussagen zur Durchf{\"u}hrung von Sprachhandlungen zu erstellen und zu verstehen und die f{\"u}r einen bestimmten Kontext am besten geeigneten auszuw{\"a}hlen, kann sich als effizient erweisen. Die hier vorgestellte Arbeit zielt darauf ab, der wissenschaftlichen Gemeinschaft und insbesondere denjenigen, die direkt und indirekt am Unterrichtsprozess beteiligt sind, das Konzept der verbalen Pragmatik bekannt zu machen und es anderen wie Grammatik, Kultur oder Interkulturalit{\"a}t gegen{\"u}ber zu stellen. Ferner wendet sie sich der Frage zu, wie man auf die Bedeutung und die dringende Notwendigkeit aufmerksam macht, Pragmatik als relevante Disziplin im Kommunikationsprozess zu etablieren; dabei wird insbesondere auf ihre systematische Einbeziehung in Lehrb{\"u}chern f{\"u}r Spanisch als Fremdsprache, die f{\"u}r den schulischen Kontext konzipiert wurden, abgestellt. Dazu werden das Vorhandensein pragmatischer Elemente und die F{\"o}rderung pragmatischer Kompetenz in Lehrb{\"u}chern f{\"u}r Anf{\"a}nger sowie ihre Relevanz bei der Festlegung von Inhalten, Fortschrittsart und Methodik untersucht.}, language = {es} } @phdthesis{Jakobs2019, author = {Jakobs, Friedrich}, title = {Dubrovin-rings and their connection to Hughes-free skew fields of fractions}, doi = {10.25932/publishup-43556}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-435561}, school = {Universit{\"a}t Potsdam}, pages = {ix, 62}, year = {2019}, abstract = {One method of embedding groups into skew fields was introduced by A. I. Mal'tsev and B. H. Neumann (cf. [18, 19]). If G is an ordered group and F is a skew field, the set F((G)) of formal power series over F in G with well-ordered support forms a skew field into which the group ring F[G] can be embedded. Unfortunately it is not suficient that G is left-ordered since F((G)) is only an F-vector space in this case as there is no natural way to define a multiplication on F((G)). One way to extend the original idea onto left-ordered groups is to examine the endomorphism ring of F((G)) as explored by N. I. Dubrovin (cf. [5, 6]). It is possible to embed any crossed product ring F[G; η, σ] into the endomorphism ring of F((G)) such that each non-zero element of F[G; η, σ] defines an automorphism of F((G)) (cf. [5, 10]). Thus, the rational closure of F[G; η, σ] in the endomorphism ring of F((G)), which we will call the Dubrovin-ring of F[G; η, σ], is a potential candidate for a skew field of fractions of F[G; η, σ]. The methods of N. I. Dubrovin allowed to show that specific classes of groups can be embedded into a skew field. For example, N. I. Dubrovin contrived some special criteria, which are applicable on the universal covering group of SL(2, R). These methods have also been explored by J. Gr{\"a}ter and R. P. Sperner (cf. [10]) as well as N.H. Halimi and T. Ito (cf. [11]). Furthermore, it is of interest to know if skew fields of fractions are unique. For example, left and right Ore domains have unique skew fields of fractions (cf. [2]). This is not the general case as for example the free group with 2 generators can be embedded into non-isomorphic skew fields of fractions (cf. [12]). It seems likely that Ore domains are the most general case for which unique skew fields of fractions exist. One approach to gain uniqueness is to restrict the search to skew fields of fractions with additional properties. I. Hughes has defined skew fields of fractions of crossed product rings F[G; η, σ] with locally indicable G which fulfill a special condition. These are called Hughes-free skew fields of fractions and I. Hughes has proven that they are unique if they exist [13, 14]. This thesis will connect the ideas of N. I. Dubrovin and I. Hughes. The first chapter contains the basic terminology and concepts used in this thesis. We present methods provided by N. I. Dubrovin such as the complexity of elements in rational closures and special properties of endomorphisms of the vector space of formal power series F((G)). To combine the ideas of N.I. Dubrovin and I. Hughes we introduce Conradian left-ordered groups of maximal rank and examine their connection to locally indicable groups. Furthermore we provide notations for crossed product rings, skew fields of fractions as well as Dubrovin-rings and prove some technical statements which are used in later parts. The second chapter focuses on Hughes-free skew fields of fractions and their connection to Dubrovin-rings. For that purpose we introduce series representations to interpret elements of Hughes-free skew fields of fractions as skew formal Laurent series. This 1 Introduction allows us to prove that for Conradian left-ordered groups G of maximal rank the statement "F[G; η, σ] has a Hughes-free skew field of fractions" implies "The Dubrovin ring of F [G; η, σ] is a skew field". We will also prove the reverse and apply the results to give a new prove of Theorem 1 in [13]. Furthermore we will show how to extend injective ring homomorphisms of some crossed product rings onto their Hughes-free skew fields of fractions. At last we will be able to answer the open question whether Hughes--free skew fields are strongly Hughes-free (cf. [17, page 53]).}, language = {en} } @phdthesis{Rector2019, author = {Rector, Michael V.}, title = {The acute effect of exercise on flow-mediated dilation in young people with cystic fibrosis}, doi = {10.25932/publishup-43893}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-438938}, school = {Universit{\"a}t Potsdam}, pages = {121}, year = {2019}, abstract = {Introduction: Cystic fibrosis (CF) is a genetic disease which disrupts the function of an epithelial surface anion channel, CFTR (cystic fibrosis transmembrane conductance regulator). Impairment to this channel leads to inflammation and infection in the lung causing the majority of morbidity and mortality. However, CF is a multiorgan disease affecting many tissues, including vascular smooth muscle. Studies have revealed young people with cystic fibrosis lacking inflammation and infection still demonstrate vascular endothelial dysfunction, measured per flow-mediated dilation (FMD). In other disease cohorts, i.e. diabetic and obese, endurance exercise interventions have been shown improve or taper this impairment. However, long-term exercise interventions are risky, as well as costly in terms of time and resources. Nevertheless, emerging research has correlated the acute effects of exercise with its long-term benefits and advocates the study of acute exercise effects on FMD prior to longitudinal studies. The acute effects of exercise on FMD have previously not been examined in young people with CF, but could yield insights on the potential benefits of long-term exercise interventions. The aims of these studies were to 1) develop and test the reliability of the FMD method and its applicability to study acute exercise effects; 2) compare baseline FMD and the acute exercise effect on FMD between young people with and without CF; and 3) explore associations between the acute effects of exercise on FMD and demographic characteristics, physical activity levels, lung function, maximal exercise capacity or inflammatory hsCRP levels. Methods: Thirty young volunteers (10 people with CF, 10 non-CF and 10 non-CF active matched controls) between the ages of 10 and 30 years old completed blood draws, pulmonary function tests, maximal exercise capacity tests and baseline FMD measurements, before returning approximately 1 week later and performing a 30-min constant load training at 75\% HRmax. FMD measurements were taken prior, immediately after, 30 minutes after and 1 hour after constant load training. ANOVAs and repeated measures ANOVAs were employed to explore differences between groups and timepoints, respectively. Linear regression was implemented and evaluated to assess correlations between FMD and demographic characteristics, physical activity levels, lung function, maximal exercise capacity or inflammatory hsCRP levels. For all comparisons, statistical significance was set at a p-value of α < 0.05. Results: Young people with CF presented with decreased lung function and maximal exercise capacity compared to matched controls. Baseline FMD was also significantly decreased in the CF group (CF: 5.23\% v non-CF: 8.27\% v non-CF active: 9.12\%). Immediately post-training, FMD was significantly attenuated (approximately 40\%) in all groups with CF still demonstrating the most minimal FMD. Follow-up measurements of FMD revealed a slow recovery towards baseline values 30 min post-training and improvements in the CF and non-CF active groups 60 min post-training. Linear regression exposed significant correlations between maximal exercise capacity (VO2 peak), BMI and FMD immediately post-training. Conclusion: These new findings confirm that CF vascular endothelial dysfunction can be acutely modified by exercise and will aid in underlining the importance of exercise in CF populations. The potential benefits of long-term exercise interventions on vascular endothelial dysfunction in young people with CF warrants further investigation.}, language = {en} } @phdthesis{Gabriel2019, author = {Gabriel, Christina}, title = {Entwicklung neuer St{\"a}rkederivate f{\"u}r die Anwendung als wasserbasierte Filmbildner in Farben und Lacken}, doi = {10.25932/publishup-43294}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-432942}, school = {Universit{\"a}t Potsdam}, pages = {XVIII, 160, xxxix, x1}, year = {2019}, abstract = {In den letzten Jahrzehnten fand auch in der Beschichtungsindustrie ein Umdenken hin zu umweltfreundlicheren Farben und Lacken statt. Allerdings basieren auch neue L{\"o}sungen meist nicht auf Biopolymeren und in einem noch geringeren Anteil auf wasserbasierten Beschichtungssystemen aus nachwachsenden Rohstoffen. Dies stellt den Ankn{\"u}pfungspunkt dieser Arbeit dar, in der untersucht wurde, ob das Biopolymer St{\"a}rke das Potenzial zum wasserbasierten Filmbildner f{\"u}r Farben und Lacke besitzt. Dabei m{\"u}ssen angelehnt an etablierte synthetische Marktprodukte die folgenden Kriterien erf{\"u}llt werden: Die w{\"a}ssrige Dispersion muss mindestens einen 30\%igen Feststoffgehalt haben, bei Raumtemperatur verarbeitet werden k{\"o}nnen und Viskosit{\"a}ten zwischen 10^2-10^3 mPa·s aufweisen. Die finale Beschichtung muss einen geschlossenen Film bilden und sehr gute Haftfestigkeiten zu einer spezifischen Oberfl{\"a}che, in dieser Arbeit Glas, besitzen. Als Grundlage f{\"u}r die Modifizierung der St{\"a}rke wurde eine Kombination von molekularem Abbau und chemischer Funktionalisierung ausgew{\"a}hlt. Da nicht bekannt war, welchen Einfluss die St{\"a}rkeart, die gew{\"a}hlte Abbaureaktion als auch verschiedene Substituenten auf die Dispersionsherstellung und deren Eigenschaften sowie die Beschichtungseigenschaften aus{\"u}ben k{\"o}nnten, wurden die strukturellen Parameter getrennt voneinander untersucht. Das erste Themengebiet beinhaltete den oxidativen Abbau von Kartoffel- und Palerbsenst{\"a}rke mittels des Hypochlorit-Abbaus (OCl-) und des ManOx-Abbaus (H2O2, KMnO4). Mit beiden Abbaureaktionen konnten vergleichbare gewichtsmittlere Molmassen (Mw) von 2·10^5-10^6 g/mol (GPC-MALS) hergestellt werden. Allerdings f{\"u}hrten die gew{\"a}hlten Reaktionsbedingungen beim ManOx-Abbau zur Bildung von Gelpartikeln. Diese lagen im µm-Bereich (DLS und Kryo-REM-Messungen) und hatten zur Folge, dass die ManOx-Proben deutlich erh{\"o}hte Viskosit{\"a}ten (c: 7,5 \%; 9-260 mPa·s) im Vergleich zu den OCl--Proben (4-10 mPa·s) bei scherverd{\"u}nnendem Verhalten besaßen und die Eigenschaften von viskoelastischen Gelen (G' > G'') zeigten. Des Weiteren wiesen sie reduzierte Heißwasserl{\"o}slichkeiten (95 °C, vorrangig: 70-99 \%) auf. Der OCl--Abbau f{\"u}hrte zu hydrophileren (Carboxylgruppengehalt bis zu 6,1 \%; ManOx: bis zu 3,1 \%), nach 95 °C-Behandlung vollst{\"a}ndig wasserl{\"o}slichen abgebauten St{\"a}rken, die ein Newtonsches Fließverhalten mit Eigenschaften einer viskoelastischen Fl{\"u}ssigkeit (G'' > G') hatten. Die OCl--Proben konnten im Vergleich zu den ManOx-Produkten (10-20 \%) zu konzentrierteren Dispersionen (20-40 \%) verarbeitet werden, die gleichzeitig die Einschr{\"a}nkung von anwendungsrelevanten Mw auf < 7·10^5 g/mol zuließen (Konzentration sollte > 30 \% sein). Außerdem f{\"u}hrten nur die OCl--Proben der Kartoffelst{\"a}rke zu transparenten (alle anderen waren opak) geschlossenen Beschichtungsfilmen. Somit hebt sich die Kombination von OCl--Abbau und Kartoffelst{\"a}rke mit Hinblick auf die Endanwendung ab. Das zweite Themengebiet umfasste Untersuchungen zum Einfluss von Ester- und Hydroxyalkylether-Substituenten auf Basis einer industriell abgebauten Kartoffelst{\"a}rke (Mw: 1,2·10^5 g/mol) vor allem auf die Dispersionsherstellung, die rheologischen Eigenschaften der Dispersionen und die Beschichtungseigenschaften in Kombination mit Glassubstraten. Dazu wurden Ester und Ether mit DS/MS-Werten von 0,07-0,91 synthetisiert. Die Derivate konnten zu wasserbasierten Dispersionen mit Konzentrationen von 30-45 \% verarbeitet werden, wobei bei hydrophoberen Modifikaten ein Co-L{\"o}semittel, Diethylenglycolmonobutylether (DEGBE), eingesetzt werden musste. Die Feststoffgehalte sanken dabei f{\"u}r beide Derivatklassen vor allem mit zunehmender Alkylkettenl{\"a}nge. Die anwendungsrelevanten Viskosit{\"a}ten (323-1240 mPa·s) stiegen auf Grund von Wechselwirkungen tendenziell mit DS/MS und Alkylkettenl{\"a}nge an. Hinsichtlich der Beschichtungseigenschaften erwiesen sich die Ester vergleichend zu den Ethern als die bevorzugte Substituentenklasse, da nur die Ester geschlossene, defektfreie und mehrheitlich transparente Beschichtungsfilme bildeten, die exzellente bis sehr gute Haftfestigkeiten (ISO Klasse: 0 und 1) auf Glas besaßen. Die Ether bildeten mehrheitlich br{\"u}chige Filme. Basierend auf der Kombination der Ergebnisse aus L{\"o}semittelaustausch, den rheologischen Untersuchungen und zus{\"a}tzlichen Oberfl{\"a}chenspannungsmessungen (30-61 mN/m) konnte geschlossen werden, dass wahrscheinlich fehlende oder schlechte Haftfestigkeiten vorrangig akkumuliertem Wasser in den Beschichtungsfilmen (visuell: tr{\"u}b oder weiß) geschuldet sind, w{\"a}hrend die Br{\"u}chigkeit vermutlich auf Wechselwirkungen (H-Br{\"u}cken Wechselwirkungen, hydrophobe Wechselwirkungen) zwischen den Polymeren zur{\"u}ckgef{\"u}hrt werden kann. Insgesamt scheint die Kombination aus Kartoffelst{\"a}rke basierend auf dem OCl--Abbau mit Mw < 7·10^5 g/mol und einem Estersubstituenten eine gute Wahl f{\"u}r wasserbasierte Dispersionen mit hohen Feststoffkonzentrationen (> 30 \%), guter Filmbildung und exzellenten Haftungen auf Glas zu sein.}, language = {de} } @phdthesis{RomeroMujalli2019, author = {Romero Mujalli, Daniel}, title = {Ecological modeling of adaptive evolutionary responses to rapid climate change}, doi = {10.25932/publishup-43062}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-430627}, school = {Universit{\"a}t Potsdam}, pages = {167}, year = {2019}, abstract = {A contemporary challenge in Ecology and Evolutionary Biology is to anticipate the fate of populations of organisms in the context of a changing world. Climate change and landscape changes due to anthropic activities have been of major concern in the contemporary history. Organisms facing these threats are expected to respond by local adaptation (i.e., genetic changes or phenotypic plasticity) or by shifting their distributional range (migration). However, there are limits to their responses. For example, isolated populations will have more difficulties in developing adaptive innovations by means of genetic changes than interconnected metapopulations. Similarly, the topography of the environment can limit dispersal opportunities for crawling organisms as compared to those that rely on wind. Thus, populations of species with different life history strategy may differ in their ability to cope with changing environmental conditions. However, depending on the taxon, empirical studies investigating organisms' responses to environmental change may become too complex, long and expensive; plus, complications arising from dealing with endangered species. In consequence, eco-evolutionary modeling offers an opportunity to overcome these limitations and complement empirical studies, understand the action and limitations of underlying mechanisms, and project into possible future scenarios. In this work I take a modeling approach and investigate the effect and relative importance of evolutionary mechanisms (including phenotypic plasticity) on the ability for local adaptation of populations with different life strategy experiencing climate change scenarios. For this, I performed a review on the state of the art of eco-evolutionary Individual-Based Models (IBMs) and identify gaps for future research. Then, I used the results from the review to develop an eco-evolutionary individual-based modeling tool to study the role of genetic and plastic mechanisms in promoting local adaption of populations of organisms with different life strategies experiencing scenarios of climate change and environmental stochasticity. The environment was simulated through a climate variable (e.g., temperature) defining a phenotypic optimum moving at a given rate of change. The rate of change was changed to simulate different scenarios of climate change (no change, slow, medium, rapid climate change). Several scenarios of stochastic noise color resembling different climatic conditions were explored. Results show that populations of sexual species will rely mainly on standing genetic variation and phenotypic plasticity for local adaptation. Population of species with relatively slow growth rate (e.g., large mammals) - especially those of small size - are the most vulnerable, particularly if their plasticity is limited (i.e., specialist species). In addition, whenever organisms from these populations are capable of adaptive plasticity, they can buffer fitness losses in reddish climatic conditions. Likewise, whenever they can adjust their plastic response (e.g., bed-hedging strategy) they will cope with bluish environmental conditions as well. In contrast, life strategies of high fecundity can rely on non-adaptive plasticity for their local adaptation to novel environmental conditions, unless the rate of change is too rapid. A recommended management measure is to guarantee interconnection of isolated populations into metapopulations, such that the supply of useful genetic variation can be increased, and, at the same time, provide them with movement opportunities to follow their preferred niche, when local adaptation becomes problematic. This is particularly important for bluish and reddish climatic conditions, when the rate of change is slow, or for any climatic condition when the level of stress (rate of change) is relatively high.}, language = {en} } @phdthesis{AbdelwahabHusseinAbdelwahabElsayed2019, author = {Abdelwahab Hussein Abdelwahab Elsayed, Ahmed}, title = {Probabilistic, deep, and metric learning for biometric identification from eye movements}, doi = {10.25932/publishup-46798}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-467980}, school = {Universit{\"a}t Potsdam}, pages = {vi, 65}, year = {2019}, abstract = {A central insight from psychological studies on human eye movements is that eye movement patterns are highly individually characteristic. They can, therefore, be used as a biometric feature, that is, subjects can be identified based on their eye movements. This thesis introduces new machine learning methods to identify subjects based on their eye movements while viewing arbitrary content. The thesis focuses on probabilistic modeling of the problem, which has yielded the best results in the most recent literature. The thesis studies the problem in three phases by proposing a purely probabilistic, probabilistic deep learning, and probabilistic deep metric learning approach. In the first phase, the thesis studies models that rely on psychological concepts about eye movements. Recent literature illustrates that individual-specific distributions of gaze patterns can be used to accurately identify individuals. In these studies, models were based on a simple parametric family of distributions. Such simple parametric models can be robustly estimated from sparse data, but have limited flexibility to capture the differences between individuals. Therefore, this thesis proposes a semiparametric model of gaze patterns that is flexible yet robust for individual identification. These patterns can be understood as domain knowledge derived from psychological literature. Fixations and saccades are examples of simple gaze patterns. The proposed semiparametric densities are drawn under a Gaussian process prior centered at a simple parametric distribution. Thus, the model will stay close to the parametric class of densities if little data is available, but it can also deviate from this class if enough data is available, increasing the flexibility of the model. The proposed method is evaluated on a large-scale dataset, showing significant improvements over the state-of-the-art. Later, the thesis replaces the model based on gaze patterns derived from psychological concepts with a deep neural network that can learn more informative and complex patterns from raw eye movement data. As previous work has shown that the distribution of these patterns across a sequence is informative, a novel statistical aggregation layer called the quantile layer is introduced. It explicitly fits the distribution of deep patterns learned directly from the raw eye movement data. The proposed deep learning approach is end-to-end learnable, such that the deep model learns to extract informative, short local patterns while the quantile layer learns to approximate the distributions of these patterns. Quantile layers are a generic approach that can converge to standard pooling layers or have a more detailed description of the features being pooled, depending on the problem. The proposed model is evaluated in a large-scale study using the eye movements of subjects viewing arbitrary visual input. The model improves upon the standard pooling layers and other statistical aggregation layers proposed in the literature. It also improves upon the state-of-the-art eye movement biometrics by a wide margin. Finally, for the model to identify any subject — not just the set of subjects it is trained on — a metric learning approach is developed. Metric learning learns a distance function over instances. The metric learning model maps the instances into a metric space, where sequences of the same individual are close, and sequences of different individuals are further apart. This thesis introduces a deep metric learning approach with distributional embeddings. The approach represents sequences as a set of continuous distributions in a metric space; to achieve this, a new loss function based on Wasserstein distances is introduced. The proposed method is evaluated on multiple domains besides eye movement biometrics. This approach outperforms the state of the art in deep metric learning in several domains while also outperforming the state of the art in eye movement biometrics.}, language = {en} } @phdthesis{Guislain2019, author = {Guislain, Alexis}, title = {Eco-physiological consequences of fluctuating light on phytoplankton}, doi = {10.25932/publishup-46927}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-469272}, school = {Universit{\"a}t Potsdam}, pages = {161}, year = {2019}, abstract = {Phytoplankton growth depends not only on the mean intensity but also on the dynamics of the light supply. The nonlinear light-dependency of growth is characterized by a small number of basic parameters: the compensation light intensity PARcompμ, where production and losses are balanced, the growth efficiency at sub-saturating light αµ, and the maximum growth rate at saturating light µmax. In surface mixed layers, phytoplankton may rapidly move between high light intensities and almost darkness. Because of the different frequency distribution of light and/or acclimation processes, the light-dependency of growth may differ between constant and fluctuating light. Very few studies measured growth under fluctuating light at a sufficient number of mean light intensities to estimate the parameters of the growth-irradiance relationship. Hence, the influence of light dynamics on µmax, αµ and PARcompμ are still largely unknown. By extension, accurate modelling predictions of phytoplankton development under fluctuating light exposure remain difficult to make. This PhD thesis does not intend to directly extrapolate few experimental results to aquatic systems - but rather improving the mechanistic understanding of the variation of the light-dependency of growth under light fluctuations and effects on phytoplankton development. In Lake TaiHu and at the Three Gorges Reservoir (China), we incubated phytoplankton communities in bottles placed either at fixed depths or moved vertically through the water column to mimic vertical mixing. Phytoplankton at fixed depths received only the diurnal changes in light (defined as constant light regime), while phytoplankton received rapidly fluctuating light by superimposing the vertical light gradient on the natural sinusoidal diurnal sunlight. The vertically moved samples followed a circular movement with 20 min per revolution, replicating to some extent the full overturn of typical Langmuir cells. Growth, photosynthesis, oxygen production and respiration of communities (at Lake TaiHu) were measured. To complete these investigations, a physiological experiment was performed in the laboratory on a toxic strain of Microcystis aeruginosa (FACBH 1322) incubated under 20 min period fluctuating light. Here, we measured electron transport rates and net oxygen production at a much higher time resolution (single minute timescale). The present PhD thesis provides evidence for substantial effects of fluctuating light on the eco-physiology of phytoplankton. Both experiments performed under semi-natural conditions in Lake TaiHu and at the Three Gorges Reservoir gave similar results. The significant decline in community growth efficiencies αµ under fluctuating light was caused for a great share by different frequency distribution of light intensities that shortened the effective daylength for production. The remaining gap in community αµ was attributed to species-specific photoacclimation mechanisms and to light-dependent respiratory losses. In contrast, community maximal growth rates µmax were similar between incubations at constant and fluctuating light. At daily growth saturating light supply, differences in losses for biosynthesis between the two light regimes were observed. Phytoplankton experiencing constant light suffered photo-inhibition - leading to photosynthesis foregone and additional respiratory costs for photosystems repair. On the contrary, intermittent exposure to low and high light intensities prevented photo-inhibition of mixed algae but forced them to develop alternative light strategy. They better harvested and exploited surface irradiance by enhancing their photosynthesis. In the laboratory, we showed that Microcystis aeruginosa increased its oxygen consumption by dark respiration in the light few minutes only after exposure to increasing light intensities. More, we proved that within a simulated Langmuir cell, the net production at saturating light and the compensation light intensity for production at limiting light are positively related. These results are best explained by an accumulation of photosynthetic products at increasing irradiance and mobilization of these fresh resources by rapid enhancement of dark respiration for maintenance and biosynthesis at decreasing irradiance. At the daily timescale, we showed that the enhancement of photosynthesis at high irradiance for biosynthesis of species increased their maintenance respiratory costs at limiting light. Species-specific growth at saturating light µmax and compensation light intensity for growth PARcompμ of species incubated in Lake TaiHu were positively related. Because of this species-specific physiological tradeoff, species displayed different light affinities to limiting and saturating light - thereby exhibiting a gleaner-opportunist tradeoff. In Lake TaiHu, we showed that inter-specific differences in light acquisition traits (µmax and PARcompμ) allowed coexis¬tence of species on a gradient of constant light while avoiding competitive exclusion. More interestingly we demonstrated for the first time that vertical mixing (inducing fluctuating light supply for phytoplankton) may alter or even reverse the light utilization strategies of species within couple of days. The intra-specific variation in traits under fluctuating light increased the niche space for acclimated species, precluding competitive exclusion. Overall, this PhD thesis contributes to a better understanding of phytoplankton eco-physiology under fluctuating light supply. This work could enhance the quality of predictions of phytoplankton development under certain weather conditions or climate change scenarios.}, language = {en} } @phdthesis{Vranic2019, author = {Vranic, Marija}, title = {3D Structure of the biomarker hepcidin-25 in its native state}, doi = {10.25932/publishup-45929}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-459295}, school = {Universit{\"a}t Potsdam}, pages = {xii, 135}, year = {2019}, abstract = {Hepcidin-25 (Hep-25) plays a crucial role in the control of iron homeostasis. Since the dysfunction of the hepcidin pathway leads to multiple diseases as a result of iron imbalance, hepcidin represents a potential target for the diagnosis and treatment of disorders of iron metabolism. Despite intense research in the last decade targeted at developing a selective immunoassay for iron disorder diagnosis and treatment and better understanding the ferroportin-hepcidin interaction, questions remain. The key to resolving these underlying questions is acquiring exact knowledge of the 3D structure of native Hep-25. Since it was determined that the N-terminus, which is responsible for the bioactivity of Hep-25, contains a small Cu(II)-binding site known as the ATCUN motif, it was assumed that the Hep-25-Cu(II) complex is the native, bioactive form of the hepcidin. This structure has thus far not been elucidated in detail. Owing to the lack of structural information on metal-bound Hep-25, little is known about its possible biological role in iron metabolism. Therefore, this work is focused on structurally characterizing the metal-bound Hep-25 by NMR spectroscopy and molecular dynamics simulations. For the present work, a protocol was developed to prepare and purify properly folded Hep-25 in high quantities. In order to overcome the low solubility of Hep-25 at neutral pH, we introduced the C-terminal DEDEDE solubility tag. The metal binding was investigated through a series of NMR spectroscopic experiments to identify the most affected amino acids that mediate metal coordination. Based on the obtained NMR data, a structural calculation was performed in order to generate a model structure of the Hep-25-Ni(II) complex. The DEDEDE tag was excluded from the structural calculation due to a lack of NMR restraints. The dynamic nature and fast exchange of some of the amide protons with solvent reduced the overall number of NMR restraints needed for a high-quality structure. The NMR data revealed that the 20 Cterminal Hep-25 amino acids experienced no significant conformational changes, compared to published results, as a result of a pH change from pH 3 to pH 7 and metal binding. A 3D model of the Hep-25-Ni(II) complex was constructed from NMR data recorded for the hexapeptideNi(II) complex and Hep-25-DEDEDE-Ni(II) complex in combination with the fixed conformation of 19 C-terminal amino acids. The NMR data of the Hep-25-DEDEDE-Ni(II) complex indicates that the ATCUN motif moves independently from the rest of the structure. The 3D model structure of the metal-bound Hep-25 allows for future works to elucidate hepcidin's interaction with its receptor ferroportin and should serve as a starting point for the development of antibodies with improved selectivity.}, language = {en} } @phdthesis{Schmidt2019, author = {Schmidt, Martin}, title = {Fragmentation of landscapes: modelling ecosystem services of transition zones}, doi = {10.25932/publishup-44294}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-442942}, school = {Universit{\"a}t Potsdam}, pages = {XV, 103}, year = {2019}, abstract = {For millennia, humans have affected landscapes all over the world. Due to horizontal expansion, agriculture plays a major role in the process of fragmentation. This process is caused by a substitution of natural habitats by agricultural land leading to agricultural landscapes. These landscapes are characterized by an alternation of agriculture and other land use like forests. In addition, there are landscape elements of natural origin like small water bodies. Areas of different land use are beside each other like patches, or fragments. They are physically distinguishable which makes them look like a patchwork from an aerial perspective. These fragments are each an own ecosystem with conditions and properties that differ from their adjacent fragments. As open systems, they are in exchange of information, matter and energy across their boundaries. These boundary areas are called transition zones. Here, the habitat properties and environmental conditions are altered compared to the interior of the fragments. This changes the abundance and the composition of species in the transition zones, which in turn has a feedback effect on the environmental conditions. The literature mainly offers information and insights on species abundance and composition in forested transition zones. Abiotic effects, the gradual changes in energy and matter, received less attention. In addition, little is known about non-forested transition zones. For example, the effects on agricultural yield in transition zones of an altered microclimate, matter dynamics or different light regimes are hardly researched or understood. The processes in transition zones are closely connected with altered provisioning and regulating ecosystem services. To disentangle the mechanisms and to upscale the effects, models can be used. My thesis provides insights into these topics: literature was reviewed and a conceptual framework for the quantitative description of gradients of matter and energy in transition zones was introduced. The results of measurements of environmental gradients like microclimate, aboveground biomass and soil carbon and nitrogen content are presented that span from within the forest into arable land. Both the measurements and the literature review could not validate a transition zone of 100 m for abiotic effects. Although this value is often reported and used in the literature, it is likely to be smaller. Further, the measurements suggest that on the one hand trees in transition zones are smaller compared to those in the interior of the fragments, while on the other hand less biomass was measured in the arable lands' transition zone. These results support the hypothesis that less carbon is stored in the aboveground biomass in transition zones. The soil at the edge (zero line) between adjacent forest and arable land contains more nitrogen and carbon content compared to the interior of the fragments. One-year measurements in the transition zone also provided evidence that microclimate is different compared to the fragments' interior. To predict the possible yield decreases that transition zones might cause, a modelling approach was developed. Using a small virtual landscape, I modelled the effect of a forest fragment shading the adjacent arable land and the effects of this on yield using the MONICA crop growth model. In the transition zone yield was less compared to the interior due to shading. The results of the simulations were upscaled to the landscape level and exemplarily calculated for the arable land of a whole region in Brandenburg, Germany. The major findings of my thesis are: (1) Transition zones are likely to be much smaller than assumed in the scientific literature; (2) transition zones aren't solely a phenomenon of forested ecosystems, but significantly extend into arable land as well; (3) empirical and modelling results show that transition zones encompass biotic and abiotic changes that are likely to be important to a variety of agricultural landscape ecosystem services.}, language = {en} } @phdthesis{He2019, author = {He, Hai}, title = {Exploring and engineering formaldehyde assimilation}, doi = {10.25932/publishup-47386}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-473867}, school = {Universit{\"a}t Potsdam}, pages = {vi, 105}, year = {2019}, abstract = {Increasing concerns regarding the environmental impact of our chemical production have shifted attention towards possibilities for sustainable biotechnology. One-carbon (C1) compounds, including methane, methanol, formate and CO, are promising feedstocks for future bioindustry. CO2 is another interesting feedstock, as it can also be transformed using renewable energy to other C1 feedstocks for use. While formaldehyde is not suitable as a feedstock due to its high toxicity, it is a central intermediate in the process of C1 assimilation. This thesis explores formaldehyde metabolism and aims to engineer formaldehyde assimilation in the model organism Escherichia coli for the future C1-based bioindustry. The first chapter of the thesis aims to establish growth of E. coli on formaldehyde via the most efficient naturally occurring route, the ribulose monophosphate pathway. Linear variants of the pathway were constructed in multiple-gene knockouts strains, coupling E. coli growth to the activities of the key enzymes of the pathway. Formaldehyde-dependent growth was achieved in rationally designed strains. In the final strain, the synthetic pathway provides the cell with almost all biomass and energy requirements. In the second chapter, taking advantage of the unique feature of its reactivity, formaldehyde assimilation via condensation with glycine and pyruvate by two promiscuous aldolases was explored. Facilitated by these two reactions, the newly designed homoserine cycle is expected to support higher yields of a wide array of products than its counterparts. By dividing the pathway into segments and coupling them to the growth of dedicated strains, all pathway reactions were demonstrated to be sufficiently active. The work paves a way for future implementation of a highly efficient route for C1 feedstocks into commodity chemicals. In the third chapter, the in vivo rate of the spontaneous formaldehyde tetrahydrofolate condensation to methylene-tetrahydrofolate was assessed in order to evaluate its applicability as a biotechnological process. Tested within an E. coli strain deleted in essential genes for native methylene-tetrahydrofolate biosynthesis, the reaction was shown to support the production of this essential intermediate. However, only low growth rates were observed and only at high formaldehyde concentrations. Computational analysis dependent on in vivo evidence from this strain deduced the slow rate of this spontaneous reaction, thus ruling out its substantial contribution to growth on C1 feedstocks. The reactivity of formaldehyde makes it highly toxic. In the last chapter, the formation of thioproline, the condensation product of cysteine and formaldehyde, was confirmed to contribute this toxicity effect. Xaa-Pro aminopeptidase (PepP), which genetically links with folate metabolism, was shown to hydrolyze thioproline-containing peptides. Deleting pepP increased strain sensitivity to formaldehyde, pointing towards the toxicity of thioproline-containing peptides and the importance of their removal. The characterization in this study could be useful in handling this toxic intermediate. Overall, this thesis identified challenges related to formaldehyde metabolism and provided novel solutions towards a future bioindustry based on sustainable C1 feedstocks in which formaldehyde serves as a key intermediate.}, language = {en} } @phdthesis{Crisologo2019, author = {Crisologo, Irene}, title = {Using spaceborne radar platforms to enhance the homogeneity of weather radar calibration}, doi = {10.25932/publishup-44570}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-445704}, school = {Universit{\"a}t Potsdam}, pages = {xvii, 61}, year = {2019}, abstract = {Accurate weather observations are the keystone to many quantitative applications, such as precipitation monitoring and nowcasting, hydrological modelling and forecasting, climate studies, as well as understanding precipitation-driven natural hazards (i.e. floods, landslides, debris flow). Weather radars have been an increasingly popular tool since the 1940s to provide high spatial and temporal resolution precipitation data at the mesoscale, bridging the gap between synoptic and point scale observations. Yet, many institutions still struggle to tap the potential of the large archives of reflectivity, as there is still much to understand about factors that contribute to measurement errors, one of which is calibration. Calibration represents a substantial source of uncertainty in quantitative precipitation estimation (QPE). A miscalibration of a few dBZ can easily deteriorate the accuracy of precipitation estimates by an order of magnitude. Instances where rain cells carrying torrential rains are misidentified by the radar as moderate rain could mean the difference between a timely warning and a devastating flood. Since 2012, the Philippine Atmospheric, Geophysical, and Astronomical Services Administration (PAGASA) has been expanding the country's ground radar network. We had a first look into the dataset from one of the longest running radars (the Subic radar) after devastating week-long torrential rains and thunderstorms in August 2012 caused by the annual southwestmonsoon and enhanced by the north-passing Typhoon Haikui. The analysis of the rainfall spatial distribution revealed the added value of radar-based QPE in comparison to interpolated rain gauge observations. However, when compared with local gauge measurements, severe miscalibration of the Subic radar was found. As a consequence, the radar-based QPE would have underestimated the rainfall amount by up to 60\% if they had not been adjusted by rain gauge observations—a technique that is not only affected by other uncertainties, but which is also not feasible in other regions of the country with very sparse rain gauge coverage. Relative calibration techniques, or the assessment of bias from the reflectivity of two radars, has been steadily gaining popularity. Previous studies have demonstrated that reflectivity observations from the Tropical Rainfall Measuring Mission (TRMM) and its successor, the Global Precipitation Measurement (GPM), are accurate enough to serve as a calibration reference for ground radars over low-to-mid-latitudes (± 35 deg for TRMM; ± 65 deg for GPM). Comparing spaceborne radars (SR) and ground radars (GR) requires cautious consideration of differences in measurement geometry and instrument specifications, as well as temporal coincidence. For this purpose, we implement a 3-D volume matching method developed by Schwaller and Morris (2011) and extended by Warren et al. (2018) to 5 years worth of observations from the Subic radar. In this method, only the volumetric intersections of the SR and GR beams are considered. Calibration bias affects reflectivity observations homogeneously across the entire radar domain. Yet, other sources of systematic measurement errors are highly heterogeneous in space, and can either enhance or balance the bias introduced by miscalibration. In order to account for such heterogeneous errors, and thus isolate the calibration bias, we assign a quality index to each matching SR-GR volume, and thus compute the GR calibration bias as a qualityweighted average of reflectivity differences in any sample of matching SR-GR volumes. We exemplify the idea of quality-weighted averaging by using beam blockage fraction (BBF) as a quality variable. Quality-weighted averaging is able to increase the consistency of SR and GR observations by decreasing the standard deviation of the SR-GR differences, and thus increasing the precision of the bias estimates. To extend this framework further, the SR-GR quality-weighted bias estimation is applied to the neighboring Tagaytay radar, but this time focusing on path-integrated attenuation (PIA) as the source of uncertainty. Tagaytay is a C-band radar operating at a lower wavelength and is therefore more affected by attenuation. Applying the same method used for the Subic radar, a time series of calibration bias is also established for the Tagaytay radar. Tagaytay radar sits at a higher altitude than the Subic radar and is surrounded by a gentler terrain, so beam blockage is negligible, especially in the overlapping region. Conversely, Subic radar is largely affected by beam blockage in the overlapping region, but being an SBand radar, attenuation is considered negligible. This coincidentally independent uncertainty contributions of each radar in the region of overlap provides an ideal environment to experiment with the different scenarios of quality filtering when comparing reflectivities from the two ground radars. The standard deviation of the GR-GR differences already decreases if we consider either BBF or PIA to compute the quality index and thus the weights. However, combining them multiplicatively resulted in the largest decrease in standard deviation, suggesting that taking both factors into account increases the consistency between the matched samples. The overlap between the two radars and the instances of the SR passing over the two radars at the same time allows for verification of the SR-GR quality-weighted bias estimation method. In this regard, the consistency between the two ground radars is analyzed before and after bias correction is applied. For cases when all three radars are coincident during a significant rainfall event, the correction of GR reflectivities with calibration bias estimates from SR overpasses dramatically improves the consistency between the two ground radars which have shown incoherent observations before correction. We also show that for cases where adequate SR coverage is unavailable, interpolating the calibration biases using a moving average can be used to correct the GR observations for any point in time to some extent. By using the interpolated biases to correct GR observations, we demonstrate that bias correction reduces the absolute value of the mean difference in most cases, and therefore improves the consistency between the two ground radars. This thesis demonstrates that in general, taking into account systematic sources of uncertainty that are heterogeneous in space (e.g. BBF) and time (e.g. PIA) allows for a more consistent estimation of calibration bias, a homogeneous quantity. The bias still exhibits an unexpected variability in time, which hints that there are still other sources of errors that remain unexplored. Nevertheless, the increase in consistency between SR and GR as well as between the two ground radars, suggests that considering BBF and PIA in a weighted-averaging approach is a step in the right direction. Despite the ample room for improvement, the approach that combines volume matching between radars (either SR-GR or GR-GR) and quality-weighted comparison is readily available for application or further scrutiny. As a step towards reproducibility and transparency in atmospheric science, the 3D matching procedure and the analysis workflows as well as sample data are made available in public repositories. Open-source software such as Python and wradlib are used for all radar data processing in this thesis. This approach towards open science provides both research institutions and weather services with a valuable tool that can be applied to radar calibration, from monitoring to a posteriori correction of archived data.}, language = {en} } @phdthesis{Mandal2019, author = {Mandal, Sankalita}, title = {Event handling in business processes}, doi = {10.25932/publishup-44170}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-441700}, school = {Universit{\"a}t Potsdam}, pages = {xix, 151}, year = {2019}, abstract = {Business process management (BPM) deals with modeling, executing, monitoring, analyzing, and improving business processes. During execution, the process communicates with its environment to get relevant contextual information represented as events. Recent development of big data and the Internet of Things (IoT) enables sources like smart devices and sensors to generate tons of events which can be filtered, grouped, and composed to trigger and drive business processes. The industry standard Business Process Model and Notation (BPMN) provides several event constructs to capture the interaction possibilities between a process and its environment, e.g., to instantiate a process, to abort an ongoing activity in an exceptional situation, to take decisions based on the information carried by the events, as well as to choose among the alternative paths for further process execution. The specifications of such interactions are termed as event handling. However, in a distributed setup, the event sources are most often unaware of the status of process execution and therefore, an event is produced irrespective of the process being ready to consume it. BPMN semantics does not support such scenarios and thus increases the chance of processes getting delayed or getting in a deadlock by missing out on event occurrences which might still be relevant. The work in this thesis reviews the challenges and shortcomings of integrating real-world events into business processes, especially the subscription management. The basic integration is achieved with an architecture consisting of a process modeler, a process engine, and an event processing platform. Further, points of subscription and unsubscription along the process execution timeline are defined for different BPMN event constructs. Semantic and temporal dependencies among event subscription, event occurrence, event consumption and event unsubscription are considered. To this end, an event buffer with policies for updating the buffer, retrieving the most suitable event for the current process instance, and reusing the event has been discussed that supports issuing of early subscription. The Petri net mapping of the event handling model provides our approach with a translation of semantics from a business process perspective. Two applications based on this formal foundation are presented to support the significance of different event handling configurations on correct process execution and reachability of a process path. Prototype implementations of the approaches show that realizing flexible event handling is feasible with minor extensions of off-the-shelf process engines and event platforms.}, language = {en} } @phdthesis{Meyer2019, author = {Meyer, Ljuba}, title = {Bildungsort Familie}, doi = {10.25932/publishup-44431}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-444319}, school = {Universit{\"a}t Potsdam}, pages = {V, 438}, year = {2019}, abstract = {In der Bildungs- und Familienforschung wird die intergenerationale Weitergabe von Bildung innerhalb der Familie haupts{\"a}chlich unter dem Blickwinkel des schulischen Erfolges der nachwachsenden Generation thematisiert. „Wie" aber bildungsbezogene Transferprozesse innerhalb der Familie konkret ablaufen, bleibt jedoch in der deutschen Forschungslandschaft weitestgehend unbearbeitet. An dieser Stelle setzt diese qualitativ angelegte Arbeit an. Ziel dieser Arbeit ist, bildungsbezogene Transferprozesse innerhalb von russischen Dreigenerationenfamilien, die aus der ehemaligen Sowjetunion nach Berlin seit 1989 ausgewandert sind und zwischen der Großeltern-, Elterngeneration und der Enkelgeneration ablaufen, zu untersuchen. Hinter diesen Transferprozessen verbergen sich im Sinne Bourdieus bewusste und unbewusste Bildungsstrategien der interviewten Familienmitglieder. Im Rahmen dieser Arbeit wurden zwei Sp{\"a}taussiedlerfamilien - zu diesen z{\"a}hlen Familie Hoffmann und Familie Popow, sowie zwei russisch-j{\"u}dische Familien - zu diesen z{\"a}hlen Familie Rosenthal und Familie Buchbinder, interviewt. Es wurden mit den einzelnen Mitgliedern der vier untersuchten Dreigenerationenfamilien Gruppendiskussionen sowie mit je einem Vertreter einer Generation leitfadengest{\"u}tzte Einzelinterviews gef{\"u}hrt. Die Erhebungsphase fand in Berlin im Zeitraum von 2010 bis 2012 statt. Das auf diese Weise gewonnene empirische Material wurde mithilfe der dokumentarischen Methode nach Bohnsack ausgewertet. Hierdurch wurde es m{\"o}glich die implizite Selbstverst{\"a}ndlichkeit, mit der sich Bildung in Familien nach Bourdieu habituell vollzieht, einzufangen und rekonstruierbar zu machen. In der Arbeit wurden eine habitustheoretische Interpretation der russischen Dreigenerationenfamilien und die entsprechende Feldanalyse nach Bourdieu vorgenommen. In diesem Zusammenhang wurde der soziale Raum der untersuchten Familien in der Ankunftsgesellschaft bez{\"u}glich ihres Vergleichshorizontes der Herkunftsgesellschaft rekonstruiert. Weiter wurde der Bildungstransfer vor dem jeweiligen Erlebnishintergrund der einzelnen Familien untersucht und diesbez{\"u}glich eine Typisierung vorgenommen. Im Rahmen dieser Untersuchung konnten neue Erkenntnisse zum bisher unerforschten Feld des Bildungstransfers russischer Dreigenerationenfamilien in Berlin gewonnen werden. Ein wesentliches Ergebnis dieser Arbeit ist, dass die Anwendung von Bourdieus Klassentheorie auch auf Gruppen, die in einer sozialistischen Gesellschaft sozialisiert wurden und in eine kapitalistisch orientierte Gesellschaft ausgewandert sind, produktiv sein kann. Ein weiteres zentrales Ergebnis der Studie ist, dass bei zwei der vier untersuchten Familien die Migration den intergenerationalen Bildungstransfer beeinflusste. In diesem Zusammenhang weist Familie Rosenthal durch die Migration einen „gespaltenen" Habitus auf. Dieser ist darauf zur{\"u}ckzuf{\"u}hren, dass diese Familie bei der Planung des Berufes f{\"u}r die Enkelin in Berlin sich am Praktischen und Notwendigen orientierte. W{\"a}hrend die bewusste Bildungsstrategie der Großeltern- und Elterngeneration f{\"u}r die Enkelgeneration im Ankunftsland dem Habitus der Notwendigkeit, den Bourdieu der Arbeiterklasse zuschreibt, zugeordnet werden kann, l{\"a}sst sich hingegen das Freizeitverhalten der Familie Rosenthal dem Habitus der Distinktion zuordnen, der typisch f{\"u}r die herrschende Klasse ist. Ein weiterer Befund dieser Untersuchung ist, dass im Vergleich zur Enkelin Rosenthal bei der Enkelin Popow eine sogenannte Sph{\"a}rendiskrepanz rekonstruiert wurde. So ist die Enkelin Popow in der {\"a}ußeren Sph{\"a}re der Schule auf sich gestellt, da die Großeltern- und Elterngeneration zum deutschen Schulsystem nur {\"u}ber einen geringen Informationsstand verf{\"u}gen. Die Enkelin grenzt sich einerseits von ihrer Familie (innere Sph{\"a}re) und deutschen Schulabbrechern ({\"a}ußere Sph{\"a}re) ab, orientiert sich aber andererseits beim Versuch sozial aufzusteigen an russischsprachigen Peers, die die gymnasiale Oberstufe besuchen (dritte Sph{\"a}re). Bei Enkelin Popow fungiert demzufolge die Peergruppe und nicht die Familie als zentraler Bildungsort. An dieser Stelle sei angemerkt, dass sowohl bei einer russisch-j{\"u}dischen Familie als auch bei einer Sp{\"a}taussiedlerfamilie der intergenerationale Bildungstransfer durch die Migration beeinflusst wurde. W{\"a}hrend Familie Rosenthal in der Herkunftsgesellschaft der Intelligenzija zuzuordnen ist, geh{\"o}rt Familie Popow der Arbeiterschaft an. Daraus folgt, dass der intergenerationale Bildungstransfer der untersuchten Familien sowohl unabh{\"a}ngig vom Sp{\"a}taussiedler- und Kontingentfl{\"u}chtlingsstatus als auch vom herkunftsortspezifischen sozialen Status abl{\"a}uft. Demnach kann geschlussfolgert werden, dass im Rahmen dieser Studie die Migration ein zentraler Faktor f{\"u}r den intergenerationalen Bildungstransfer ist.}, language = {de} } @phdthesis{Fuhr2019, author = {Fuhr, Antonie}, title = {Eine Hypothese {\"u}ber die Grundlagen von Moral und einige Implikationen}, doi = {10.25932/publishup-44309}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-443091}, school = {Universit{\"a}t Potsdam}, pages = {172}, year = {2019}, abstract = {In der Dissertationsarbeit mit dem Titel „Eine Hypothese {\"u}ber die Grundlagen von Moral und einige Implikationen" unternimmt die Autorin den Versuch, die anthropologischen Pr{\"a}missen moralischen Handelns herauszuarbeiten. Es wird eine Hypothese aufgestellt und erl{\"a}utert, die behauptet, dass moralisches Handeln nur dann verst{\"a}ndlich wird, wenn der Handelnde erstens die F{\"a}higkeit der Phantasie aufweist, zweitens auf Erfahrungen (mittels seines Ged{\"a}chtnisses) zugreifen kann und durch Konversation mit anderen Personen interagierte und interagiert, denn nur auf der Basis dieser drei Grundlagen von Moral k{\"o}nnen sich diejenigen F{\"a}higkeiten ent¬wickeln, die als Voraussetzungen moralischen Handeln gesehen werden m{\"u}ssen: Selbstbewusstsein, Freiheit, die Entwicklung eines Wir-Gef{\"u}hls, die Genese eines moralischen Ideals und die F{\"a}higkeit, sich im Entscheiden und Handeln nach diesem Ideal richten zu k{\"o}nnen. Außerdem werden in dieser Dissertation einige Implikationen dieser Hypothese auf individueller und zwischenmenschlicher Ebene diskutiert.}, language = {de} } @phdthesis{Hoang2019, author = {Hoang, Yen}, title = {De novo binning strategy to analyze and visualize multi-dimensional cytometric data}, doi = {10.25932/publishup-44307}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-443078}, school = {Universit{\"a}t Potsdam}, pages = {vii, 81, xxxii}, year = {2019}, abstract = {Since half a century, cytometry has been a major scientific discipline in the field of cytomics - the study of system's biology at single cell level. It enables the investigation of physiological processes, functional characteristics and rare events with proteins by analysing multiple parameters on an individual cell basis. In the last decade, mass cytometry has been established which increased the parallel measurement to up to 50 proteins. This has shifted the analysis strategy from conventional consecutive manual gates towards multi-dimensional data processing. Novel algorithms have been developed to tackle these high-dimensional protein combinations in the data. They are mainly based on clustering or non-linear dimension reduction techniques, or both, often combined with an upstream downsampling procedure. However, these tools have obstacles either in comprehensible interpretability, reproducibility, computational complexity or in comparability between samples and groups. To address this bottleneck, a reproducible, semi-automated cytometric data mining workflow PRI (pattern recognition of immune cells) is proposed which combines three main steps: i) data preparation and storage; ii) bin-based combinatorial variable engineering of three protein markers, the so called triploTs, and subsequent sectioning of these triploTs in four parts; and iii) deployment of a data-driven supervised learning algorithm, the cross-validated elastic-net regularized logistic regression, with these triploT sections as input variables. As a result, the selected variables from the models are ranked by their prevalence, which potentially have discriminative value. The purpose is to significantly facilitate the identification of meaningful subpopulations, which are most distinguish between two groups. The proposed workflow PRI is exemplified by a recently published public mass cytometry data set. The authors found a T cell subpopulation which is discriminative between effective and ineffective treatment of breast carcinomas in mice. With PRI, that subpopulation was not only validated, but was further narrowed down as a particular Th1 cell population. Moreover, additional insights of combinatorial protein expressions are revealed in a traceable manner. An essential element in the workflow is the reproducible variable engineering. These variables serve as basis for a clearly interpretable visualization, for a structured variable exploration and as input layers in neural network constructs. PRI facilitates the determination of marker levels in a semi-continuous manner. Jointly with the combinatorial display, it allows a straightforward observation of correlating patterns, and thus, the dominant expressed markers and cell hierarchies. Furthermore, it enables the identification and complex characterization of discriminating subpopulations due to its reproducible and pseudo-multi-parametric pattern presentation. This endorses its applicability as a tool for unbiased investigations on cell subsets within multi-dimensional cytometric data sets.}, language = {en} } @phdthesis{Arf2019, author = {Arf, Shelan Ali}, title = {Women's everyday reality of social insecurity}, doi = {10.25932/publishup-43433}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-434333}, school = {Universit{\"a}t Potsdam}, pages = {334}, year = {2019}, abstract = {Since 1980 Iraq passed through various wars and conflicts including Iraq-Iran war, Saddam Hussein's the Anfals and Halabja campaigns against the Kurds and the killing campaigns against Shiite in 1986, Saddam Hussein's invasion of Kuwait in August 1990, the Gulf war in 1990, Iraq war in 2003 and the fall of Saddam, the conflicts and chaos in the transmission of power after the death of Saddam, and the war against ISIS . All these wars left severe impacts in most households in Iraq; on women and children in particular. The consequences of such long wars could be observed in all sectors including economic, social, cultural and religious sectors. The social structure, norms and attitudes are intensely affected. Many women specifically divorced women found them-selves in challenging different difficulties such as social as well as economic situations. Thus the divorced women in Iraqi Kurdistan are the focus of this research. Considering the fact that there is very few empirical researches on this topic, a constructivist grounded theory methodology (CGT) is viewed as reliable in order to come up with a comprehensive picture about the everyday life of divorced women in Iraqi Kurdistan. Data collected in Sulaimani city in Iraqi Kurdistan. The work of Kathy Charmaz was chosen to be the main methodological context of the research and the main data collection method was individual intensive narrative interviews with divorced women. Women generally and divorced women specifically in Iraqi Kurdistan are living in a patriarchal society that passing through many changes due to the above mentioned wars among many other factors. This research is trying to study the everyday life of divorced women in such situations and the forms of social insecurity they are experiencing. The social institutions starting from the family as a very significant institution for women to the governmental and non-governmental institutions that are working to support women, and the copying strategies, are in focus in this research. The main research argument is that the family is playing ambivalent roles in divorced women's life. For instance, on one side families are revealed to be an essential source of security to most respondents, on the other side families posed also many threats and restrictions on those women. This argument supported by what called by Suad joseph "the paradox of support and suppression" . Another important finding is that the stat institution(laws , constitutions ,Offices of combating violence against woman and family) are supporting women somehow and offering them protection from the insecurities but it is clear that the existence of the laws does not stop the violence against women in Iraqi Kurdistan, As explained by Pateman because the laws /the contract is a sexual-social contract that upholds the sex rights of males and grants them more privileges than females. The political instability, Tribal social norms also play a major role in influencing the rule of law. It is noteworthy to refer that analyzing the interviews in this research showed that in spite that divorced women living in insecurities and facing difficulties but most of the respondents try to find a coping strategies to tackle difficult situations and to deal with the violence they face; these strategies are bargaining, sometimes compromising or resisting …etc. Different theories used to explain these coping strategies such as bargaining with patriarchy. Kandiyoti who stated that women living under certain restraints struggle to find way and strategies to enhance their situations. The research finding also revealed that the western liberal feminist view of agency is limited this is agree with Saba Mahmood and what she explained about Muslim women agency. For my respondents, who are divorced women, their agency reveals itself in different ways, in resisting or compromising with or even obeying the power of male relatives, and the normative system in the society. Agency is also explained the behavior of women contacting formal state institutions in cases of violence like the police or Offices of combating violence against woman and family.}, language = {en} } @phdthesis{Sidarenka2019, author = {Sidarenka, Uladzimir}, title = {Sentiment analysis of German Twitter}, doi = {10.25932/publishup-43742}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-437422}, school = {Universit{\"a}t Potsdam}, pages = {vii, 217}, year = {2019}, abstract = {The immense popularity of online communication services in the last decade has not only upended our lives (with news spreading like wildfire on the Web, presidents announcing their decisions on Twitter, and the outcome of political elections being determined on Facebook) but also dramatically increased the amount of data exchanged on these platforms. Therefore, if we wish to understand the needs of modern society better and want to protect it from new threats, we urgently need more robust, higher-quality natural language processing (NLP) applications that can recognize such necessities and menaces automatically, by analyzing uncensored texts. Unfortunately, most NLP programs today have been created for standard language, as we know it from newspapers, or, in the best case, adapted to the specifics of English social media. This thesis reduces the existing deficit by entering the new frontier of German online communication and addressing one of its most prolific forms—users' conversations on Twitter. In particular, it explores the ways and means by how people express their opinions on this service, examines current approaches to automatic mining of these feelings, and proposes novel methods, which outperform state-of-the-art techniques. For this purpose, I introduce a new corpus of German tweets that have been manually annotated with sentiments, their targets and holders, as well as lexical polarity items and their contextual modifiers. Using these data, I explore four major areas of sentiment research: (i) generation of sentiment lexicons, (ii) fine-grained opinion mining, (iii) message-level polarity classification, and (iv) discourse-aware sentiment analysis. In the first task, I compare three popular groups of lexicon generation methods: dictionary-, corpus-, and word-embedding-based ones, finding that dictionary-based systems generally yield better polarity lists than the last two groups. Apart from this, I propose a linear projection algorithm, whose results surpass many existing automatically-generated lexicons. Afterwords, in the second task, I examine two common approaches to automatic prediction of sentiment spans, their sources, and targets: conditional random fields (CRFs) and recurrent neural networks, obtaining higher scores with the former model and improving these results even further by redefining the structure of CRF graphs. When dealing with message-level polarity classification, I juxtapose three major sentiment paradigms: lexicon-, machine-learning-, and deep-learning-based systems, and try to unite the first and last of these method groups by introducing a bidirectional neural network with lexicon-based attention. Finally, in order to make the new classifier aware of microblogs' discourse structure, I let it separately analyze the elementary discourse units of each tweet and infer the overall polarity of a message from the scores of its EDUs with the help of two new approaches: latent-marginalized CRFs and Recursive Dirichlet Process.}, language = {en} } @phdthesis{Brase2019, author = {Brase, Alexa Kristin}, title = {Spiele um Studium und Lehre? Zur mikropolitischen Nutzung von Qualit{\"a}tsmanagementsystemen an Hochschulen in Deutschland}, doi = {10.25932/publishup-43737}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-437377}, school = {Universit{\"a}t Potsdam}, pages = {IX, 228}, year = {2019}, abstract = {Die Wissenschaftsfreiheit ist ein Grundrecht, dessen Sinn und Auslegung im Rahmen von Reformen des Hochschulsystems nicht nur der Justiz, sondern auch der Wissenschaft selbst immer wieder Anlass zur Diskussion geben, so auch im Zuge der Einf{\"u}hrung des so genannten Qualit{\"a}tsmanagements von Studium und Lehre an deutschen Hochschulen. Die vorliegende Dissertationsschrift stellt die Ergebnisse einer empirischen Studie vor, die mit einer soziologischen Betrachtung des Qualit{\"a}tsmanagements unterschiedlicher Hochschulen zu dieser Diskussion beitr{\"a}gt. Auf Grundlage der Pr{\"a}misse, dass Verlauf und Folgen einer organisationalen Innovation nur verstanden werden k{\"o}nnen, wenn der allt{\"a}gliche Umgang der Organisationsmitglieder mit den neuen Strukturen und Prozessen in die Analyse einbezogen wird, geht die Studie von der Frage aus, wie Akteurinnen und Akteure an deutschen Hochschulen die Qualit{\"a}tsmanagementsysteme ihrer Organisationen nutzen. Die qualitative inhaltsanalytische Auswertung von 26 Leitfaden-Interviews mit Prorektorinnen und -rektoren, Qualit{\"a}tsmanagement-Personal und Studiendekaninnen und -dekanen an neun Hochschulen ergibt, dass die Strategien der Akteursgruppen an den Hochschulen im Zusammenspiel mit strukturellen Aspekten unterschiedliche Dynamiken entstehen lassen, mit denen Implikationen f{\"u}r die Lehrfreiheit verbunden sind: W{\"a}hrend die Autonomie der Lehrenden durch das Qualit{\"a}tsmanagement an einigen Hochschulen unterst{\"u}tzt wird, sind sowohl Autonomie als auch Verantwortung f{\"u}r Studium und Lehre an anderen Hochschulen Gegenstand andauernder Konflikte, die auch das Qualit{\"a}tsmanagement einschließen.}, language = {de} } @phdthesis{Batoulis2019, author = {Batoulis, Kimon}, title = {Sound integration of process and decision models}, doi = {10.25932/publishup-43738}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-437386}, school = {Universit{\"a}t Potsdam}, pages = {xviii, 155}, year = {2019}, abstract = {Business process management is an established technique for business organizations to manage and support their processes. Those processes are typically represented by graphical models designed with modeling languages, such as the Business Process Model and Notation (BPMN). Since process models do not only serve the purpose of documentation but are also a basis for implementation and automation of the processes, they have to satisfy certain correctness requirements. In this regard, the notion of soundness of workflow nets was developed, that can be applied to BPMN process models in order to verify their correctness. Because the original soundness criteria are very restrictive regarding the behavior of the model, different variants of the soundness notion have been developed for situations in which certain violations are not even harmful. All of those notions do only consider the control-flow structure of a process model, however. This poses a problem, taking into account the fact that with the recent release and the ongoing development of the Decision Model and Notation (DMN) standard, an increasing number of process models are complemented by respective decision models. DMN is a dedicated modeling language for decision logic and separates the concerns of process and decision logic into two different models, process and decision models respectively. Hence, this thesis is concerned with the development of decisionaware soundness notions, i.e., notions of soundness that build upon the original soundness ideas for process models, but additionally take into account complementary decision models. Similar to the various notions of workflow net soundness, this thesis investigates different notions of decision soundness that can be applied depending on the desired degree of restrictiveness. Since decision tables are a standardized means of DMN to represent decision logic, this thesis also puts special focus on decision tables, discussing how they can be translated into an unambiguous format and how their possible output values can be efficiently determined. Moreover, a prototypical implementation is described that supports checking a basic version of decision soundness. The decision soundness notions were also empirically evaluated on models from participants of an online course on process and decision modeling as well as from a process management project of a large insurance company. The evaluation demonstrates that violations of decision soundness indeed occur and can be detected with our approach.}, language = {en} }