@article{GrudenHrenHermanetal.2012, author = {Gruden, Kristina and Hren, Matjaz and Herman, Ana and Blejec, Andrej and Albrecht, Tanja and Selbig, Joachim and Bauer, Christian G. and Schuchardt, Johannes and Or-Guil, Michal and Zupancic, Klemen and Svajger, Urban and Stabuc, Borut and Ihan, Alojz and Kopitar, Andreja Natasa and Ravnikar, Maja and Knezevic, Miomir and Rozman, Primoz and Jeras, Matjaz}, title = {A "Crossomics" study analysing variability of different components in peripheral blood of healthy caucasoid individuals}, series = {PLoS one}, volume = {7}, journal = {PLoS one}, number = {1}, publisher = {PLoS}, address = {San Fransisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0028761}, pages = {12}, year = {2012}, abstract = {Background: Different immunotherapy approaches for the treatment of cancer and autoimmune diseases are being developed and tested in clinical studies worldwide. Their resulting complex experimental data should be properly evaluated, therefore reliable normal healthy control baseline values are indispensable. Methodology/Principal Findings: To assess intra- and inter-individual variability of various biomarkers, peripheral blood of 16 age and gender equilibrated healthy volunteers was sampled on 3 different days within a period of one month. Complex "crossomics'' analyses of plasma metabolite profiles, antibody concentrations and lymphocyte subset counts as well as whole genome expression profiling in CD4(+)T and NK cells were performed. Some of the observed age, gender and BMI dependences are in agreement with the existing knowledge, like negative correlation between sex hormone levels and age or BMI related increase in lipids and soluble sugars. Thus we can assume that the distribution of all 39.743 analysed markers is well representing the normal Caucasoid population. All lymphocyte subsets, 20\% of metabolites and less than 10\% of genes, were identified as highly variable in our dataset. Conclusions/Significance: Our study shows that the intra- individual variability was at least two-fold lower compared to the inter-individual one at all investigated levels, showing the importance of personalised medicine approach from yet another perspective.}, language = {en} } @article{EremenkoMakowerBaueretal.1997, author = {Eremenko, A. V. and Makower, Alexander and Bauer, Christian G. and Kurochkin, I. N. and Scheller, Frieder W.}, title = {A bienzyme electrode for tyrosine containing peptides determination}, year = {1997}, language = {en} } @article{StrefferKaatzBaueretal.1998, author = {Streffer, Katrin and Kaatz, Helvi and Bauer, Christian G. and Makower, Alexander and Schulmeister, Thomas and Scheller, Frieder W. and Peter, Martin G. and Wollenberger, Ursula}, title = {Application of a sensitive catechol detector for determination of tyrosinase inhibitors}, year = {1998}, language = {en} } @article{BauerEremenkoKuehnetal.1998, author = {Bauer, Christian G. and Eremenko, A. V. and K{\"u}hn, A. and K{\"u}rzinger, K. and Markower, Alexander and Scheller, Frieder W.}, title = {Automated amplifield flow immunoassay for cocaine}, year = {1998}, language = {en} } @article{SchellerBauerMarkoweretal.2001, author = {Scheller, Frieder W. and Bauer, Christian G. and Markower, Alexander and Wollenberger, Ursula and Warsinke, Axel and Bier, Frank Fabian}, title = {Coupling of immunoassays with enzymatic recycling electrodes}, year = {2001}, language = {en} } @article{GhindilisMakowerBaueretal.1995, author = {Ghindilis, A. L. and Makower, Alexander and Bauer, Christian G. and Bier, Frank Fabian and Scheller, Frieder W.}, title = {Determination of p-aminophenol and catecholamines at picomolar concentrations based on recycling enzyme amplification}, year = {1995}, language = {en} } @phdthesis{Bauer1998, author = {Bauer, Christian G.}, title = {Entwicklung neuartiger Enzymimmunosensoren}, address = {Potsdam}, pages = {109 S.: graph. Darst.}, year = {1998}, language = {de} } @article{SchellerPfeifferLisdatetal.1998, author = {Scheller, Frieder W. and Pfeiffer, Dorothea and Lisdat, Fred and Bauer, Christian G. and Gajovic, Nenad}, title = {Enzyme biosensors based on oxygen detection}, year = {1998}, language = {en} } @article{SchellerMakowerGhindilisetal.1995, author = {Scheller, Frieder W. and Makower, Alexander and Ghindilis, A. L. and Bier, Frank Fabian and Ehrentreich-F{\"o}rster, Eva and Wollenberger, Ursula and Bauer, Christian G. and Micheel, Burkhard and Pfeiffer, Dorothea and Szeponik, Jan and Michael, N. and Kaden, H.}, title = {Enzyme sensors for subnanomolar concentrations}, year = {1995}, language = {en} } @article{BierEhrentreichFoersterBaueretal.1996, author = {Bier, Frank Fabian and Ehrentreich-F{\"o}rster, Eva and Bauer, Christian G. and Scheller, Frieder W.}, title = {High sensitive competitive immunodetection of 2,4-dichlorophenoxyacetic acid using enzymatic amplification with electrochemical detection}, year = {1996}, language = {en} } @article{SchellerBauerMakoweretal.2002, author = {Scheller, Frieder W. and Bauer, Christian G. and Makower, Alexander and Wollenberger, Ursula and Warsinke, Axel and Bier, Frank Fabian}, title = {Immunoassays using enzymatic amplification electrodes}, isbn = {0-7484-0791-X}, year = {2002}, language = {en} } @article{BauerKuehnGajovicetal.1999, author = {Bauer, Christian G. and K{\"u}hn, A. and Gajovic, Nenad and Skorobogatko, O. V. and Holt, P. J. and Bruce, N. C. and Makower, Alexander and Lowe, Ch. R. and Scheller, Frieder W.}, title = {New enzymen sensors for morphine and codeine based on morphine dehydrogenase and laccase}, year = {1999}, language = {en} } @article{EremenkoBauerMakoweretal.1998, author = {Eremenko, Arkadi V. and Bauer, Christian G. and Makower, Alexander and Kanne, Beate and Baumgarten, Horst and Scheller, Frieder W.}, title = {The development of a non-competitive immunoenzymometric Assay (IEMA) of cocaine}, year = {1998}, language = {en} } @article{BierEhrentreichFoersterSchelleretal.1996, author = {Bier, Frank Fabian and Ehrentreich-F{\"o}rster, Eva and Scheller, Frieder W. and Makower, Alexander and Eremenko, A. V. and Wollenberger, Ursula and Bauer, Christian G. and Pfeiffer, Dorothea and Micheel, Burkhard}, title = {Ultrasensitive biosensors}, year = {1996}, language = {en} } @article{BauerEremenkoEhrentreichFoersteretal.1996, author = {Bauer, Christian G. and Eremenko, A. V. and Ehrentreich-F{\"o}rster, Eva and Bier, Frank Fabian and Makower, Alexander and Halsall, H. B. and Heineman, W. R. and Scheller, Frieder W.}, title = {Zeptomole-detecting biosensor for alkaline phosphatase in an electroche mical immunoassay for 2,4- dichlorophenoacetic acid}, year = {1996}, language = {en} }