@unpublished{WarschburgerLehmkuhl2011, author = {Warschburger, Petra and Lehmkuhl, Ulrike}, title = {Disturbed eating behavior and its consequences}, series = {Praxis der Kinderpsychologie und Kinderpsychiatrie : Ergebnisse aus Psychotherapie, Beratung und Psychiatrie}, volume = {60}, journal = {Praxis der Kinderpsychologie und Kinderpsychiatrie : Ergebnisse aus Psychotherapie, Beratung und Psychiatrie}, number = {4}, publisher = {Vandenhoeck \& Ruprecht}, address = {G{\"o}ttingen}, issn = {0032-7034}, pages = {249 -- 252}, year = {2011}, language = {de} } @misc{Wapler2011, author = {Wapler, Philipp Sebastian}, title = {Die Effizienz in der EU-Fussionskontrolle : eine Untersuchung {\"u}ber die Bedeutung von Effizienzgewinnen in der Fusionskontrolle der EU nach Art. 2 FKVO 139/2004}, series = {Europ{\"a}ische Hochschulschriften}, volume = {5225}, journal = {Europ{\"a}ische Hochschulschriften}, publisher = {Lang}, address = {Frankfurt am Main}, isbn = {978-3-631-60795-4}, issn = {0531-7312}, pages = {256 S.}, year = {2011}, language = {de} } @article{WangHerzschuh2011, author = {Wang, Yongbo and Herzschuh, Ulrike}, title = {Reassessment of Holocene vegetation change on the upper Tibetan Plateau using the pollen-based REVEALS model}, series = {Review of palaeobotany and palynology : an international journal}, volume = {168}, journal = {Review of palaeobotany and palynology : an international journal}, number = {1}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0034-6667}, doi = {10.1016/j.revpalbo.2011.09.004}, pages = {31 -- 40}, year = {2011}, abstract = {Previous studies based on fossil pollen data have reported significant changes in vegetation on the alpine Tibetan Plateau during the Holocene. However, since the relative proportions of fossil pollen taxa are largely influenced by individual pollen productivities and the dispersal characteristics, such inferences on vegetation have the potential to be considerably biased. We therefore examined the modern pollen-vegetation relationships for four common pollen species on the Tibetan Plateau, using Extended R-value (ERV) models. Assuming an average radius of 100 m for the sampled lakes, we estimated the relevant source area of pollen (RSAP) to be 2200 m (which represents the distance from the lake). Using Poaceae as the reference taxa (Pollen Productivity Estimate, PPE = 1), ERV Submodel 2 derived relative high PPEs for the steppe and desert taxa: 2.079 +/- 0.432 for Artemisia and 5.379 +/- 1.077 for Chenopodiaceae. Low PPEs were estimated for the Cyperaceae (1.036 +/- 0.012). whose plants are characteristic of the alpine Kobresia meadows. Applying these PPEs to four fossil pollen sequences since the Late Glacial, the plant abundances on the central and north-eastern Tibetan Plateau were quantified using the "Regional Estimates of Vegetation Abundance from Large Sites" (REVEALS) model. The proportions of Artemisia and Chenopodiaceae were greatly reduced compared to their original pollen percentages in the reconstructed vegetation, owing to their high productivities and their dispersal characteristics, while Cyperaceae showed a relative increase in the vegetation reconstruction. The reconstructed vegetation assemblages of the four pollen sequence sites always yielded smaller compositional species turnovers than suggested by the pollen spectra, as revealed by Detrended Canonical Correspondence Analyses (DCCA) of the Holocene sections. The strength of the previously reported vegetation changes may therefore have been overestimated, which indicates the importance of taking into account pollen-vegetation relationships when discussing the potential drivers (such as climate, land use, atmospheric CO(2) concentrations) and implications (such as for land surface-climate feedbacks, carbon storage, and biodiversity) of vegetation change.}, language = {en} } @phdthesis{Wang2011, author = {Wang, Yongbo}, title = {Late glacial to Holocene climate and vegetation changes on the Tibetan Plateau inferred from fossil pollen records in lacustrine sediments}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-63155}, school = {Universit{\"a}t Potsdam}, year = {2011}, abstract = {The past climate in central Asia, and especially on the Tibetan Plateau (TP), is of great importance for an understanding of global climate processes and for predicting the future climate. As a major influence on the climate in this region, the Asian Summer Monsoon (ASM) and its evolutionary history are of vital importance for accurate predictions. However, neither the evolutionary pattern of the summer monsoon nor the driving mechanisms behind it are yet clearly understood. For this research, I first synthesized previously published Late Glacial to Holocene climatic records from monsoonal central Asia in order to extract the general climate signals and the associated summer monsoon intensities. New climate and vegetation sequences were then established using improved quantitative methods, focusing on fossil pollen records recovered from Tibetan lakes and also incorporating new modern datasets. The pollen-vegetation and vegetation-climate relationships on the TP were also evaluated in order to achieve a better understanding of fossil pollen records. The synthesis of previously published moisture-related palaeoclimate records in monsoonal central Asia revealed generally different temporal patterns for the two monsoonal subsystems, i.e. the Indian Summer Monsoon (ISM) and East Asian Summer Monsoon (EASM). The ISM appears to have experienced maximum wet conditions during the early Holocene, while many records from the area affected by the EASM indicate relatively dry conditions at that time, particularly in north-central China where the maximum moisture levels occurred during the middle Holocene. A detailed consideration of possible driving factors affecting the summer monsoon, including summer solar insolation and sea surface temperatures, revealed that the ISM was primarily driven by variations in northern hemisphere solar insolation, and that the EASM may have been constrained by the ISM resulting in asynchronous patterns of evolution for these two subsystems. This hypothesis is further supported by modern monsoon indices estimated using the NCEP/NCAR Reanalysis data from the last 50 years, which indicate a significant negative correlation between the two summer monsoon subsystems. By analogy with the early Holocene, intensification of the ISM during coming decades could lead to increased aridification elsewhere as a result of the asynchronous nature of the monsoon subsystems, as can already be observed in the meteorological data from the last 15 years. A quantitative climate reconstruction using fossil pollen records was achieved through analysis of sediment core recovered from Lake Donggi Cona (in the north-eastern part of the TP) which has been dated back to the Last Glacial Maximum (LGM). A new data-set of modern pollen collected from large lakes in arid to semi-arid regions of central Asia is also presented herein. The concept of "pollen source area" was introduced to modern climate calibration based on pollen from large lakes, and was applied to the fossil pollen sequence from Lake Donggi Cona. Extremely dry conditions were found to have dominated the LGM, and a subsequent gradually increasing trend in moisture during the Late Glacial period was terminated by an abrupt reversion to a dry phase that lasted for about 1000 years and coincided with the first Heinrich Event of the northern Atlantic region. Subsequent periods corresponding to the warm B{\o}lling-Aller{\o}d period and the Younger Dryas cold event were followed by moist conditions during the early Holocene, with annual precipitation of up to about 400 mm. A slightly drier trend after 9 cal ka BP was then followed by a second wet phase during the middle Holocene that lasted until 4.5 cal ka BP. Relatively steady conditions with only slight fluctuations then dominated the late Holocene, resulting in the present climatic conditions. In order to investigate the relationship between vegetation and climate, temporal variations in the possible driving factors for vegetation change on the northern TP were examined using a high resolution late Holocene pollen record from Lake Kusai. Moving-window Redundancy Analyses (RDAs) were used to evaluate the correlations between pollen assemblages and individual sedimentary proxies. These analyses have revealed frequent fluctuations in the relative abundances of alpine steppe and alpine desert components, and in particular a decrease in the total vegetation cover at around 1500 cal a BP. The climate was found to have had an important influence on vegetation changes when conditions were relatively wet and stable. However, after the 1500 cal a BP threshold in vegetation cover was crossed the vegetation appears to have been affected more by extreme events such as dust storms or fluvial erosion than by the general climatic trends. In addition, pollen spectra over the last 600 years have been revealed by Procrustes analysis to be significantly different from those recovered from older samples, which is attributed to an increased human impact that resulted in unprecedented changes to the composition of the vegetation. Theoretical models that have been developed and widely applied to the European area (i.e. the Extended R-Value (ERV) model and the Regional Estimates of Vegetation Abundance from Large Sites (REVEALS) model) have been applied to the high alpine TP ecosystems in order to investigate the pollen-vegetation relationships, as well as for quantitative reconstructions of vegetation abundance. The modern pollen-vegetation relationships for four common pollen species on the TP have been investigated using Poaceae as the reference taxa. The ERV Submodel 2 yielded relatively high PPEs for the steppe and desert taxa (Artemisia Chenopodiaceae), and low PPEs for the Cyperaceae that are characteristic of the alpine Kobresia meadows. The plant abundances on the central and north-eastern TP were quantified by applying these PPEs to four post-Late Glacial fossil pollen sequences. The reconstructed vegetation assemblages for the four pollen sequences always yielded smaller compositional species turnovers than suggested by the pollen spectra, indicating that the strength of the previously-reported vegetation changes may therefore have been overestimated. In summary, the key findings of this thesis are that (a) the two ASM subsystems show asynchronous patterns during both the Holocene and modern time periods, (b) fossil pollen records from large lakes reflect regional signals for which the pollen source areas need to be taken into account, (c) climate is not always the main driver for vegetation change, and (d) previously reported vegetation changes on the TP may have been overestimated because they ignored inter-species variations in pollen productivity.}, language = {en} } @phdthesis{Wang2011, author = {Wang, Long}, title = {X-tracking the usage interest on web sites}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-51077}, school = {Universit{\"a}t Potsdam}, year = {2011}, abstract = {The exponential expanding of the numbers of web sites and Internet users makes WWW the most important global information resource. From information publishing and electronic commerce to entertainment and social networking, the Web allows an inexpensive and efficient access to the services provided by individuals and institutions. The basic units for distributing these services are the web sites scattered throughout the world. However, the extreme fragility of web services and content, the high competence between similar services supplied by different sites, and the wide geographic distributions of the web users drive the urgent requirement from the web managers to track and understand the usage interest of their web customers. This thesis, "X-tracking the Usage Interest on Web Sites", aims to fulfill this requirement. "X" stands two meanings: one is that the usage interest differs from various web sites, and the other is that usage interest is depicted from multi aspects: internal and external, structural and conceptual, objective and subjective. "Tracking" shows that our concentration is on locating and measuring the differences and changes among usage patterns. This thesis presents the methodologies on discovering usage interest on three kinds of web sites: the public information portal site, e-learning site that provides kinds of streaming lectures and social site that supplies the public discussions on IT issues. On different sites, we concentrate on different issues related with mining usage interest. The educational information portal sites were the first implementation scenarios on discovering usage patterns and optimizing the organization of web services. In such cases, the usage patterns are modeled as frequent page sets, navigation paths, navigation structures or graphs. However, a necessary requirement is to rebuild the individual behaviors from usage history. We give a systematic study on how to rebuild individual behaviors. Besides, this thesis shows a new strategy on building content clusters based on pair browsing retrieved from usage logs. The difference between such clusters and the original web structure displays the distance between the destinations from usage side and the expectations from design side. Moreover, we study the problem on tracking the changes of usage patterns in their life cycles. The changes are described from internal side integrating conceptual and structure features, and from external side for the physical features; and described from local side measuring the difference between two time spans, and global side showing the change tendency along the life cycle. A platform, Web-Cares, is developed to discover the usage interest, to measure the difference between usage interest and site expectation and to track the changes of usage patterns. E-learning site provides the teaching materials such as slides, recorded lecture videos and exercise sheets. We focus on discovering the learning interest on streaming lectures, such as real medias, mp4 and flash clips. Compared to the information portal site, the usage on streaming lectures encapsulates the variables such as viewing time and actions during learning processes. The learning interest is discovered in the form of answering 6 questions, which covers finding the relations between pieces of lectures and the preference among different forms of lectures. We prefer on detecting the changes of learning interest on the same course from different semesters. The differences on the content and structure between two courses leverage the changes on the learning interest. We give an algorithm on measuring the difference on learning interest integrated with similarity comparison between courses. A search engine, TASK-Moniminer, is created to help the teacher query the learning interest on their streaming lectures on tele-TASK site. Social site acts as an online community attracting web users to discuss the common topics and share their interesting information. Compared to the public information portal site and e-learning web site, the rich interactions among users and web content bring the wider range of content quality, on the other hand, provide more possibilities to express and model usage interest. We propose a framework on finding and recommending high reputation articles in a social site. We observed that the reputation is classified into global and local categories; the quality of the articles having high reputation is related with the content features. Based on these observations, our framework is implemented firstly by finding the articles having global or local reputation, and secondly clustering articles based on their content relations, and then the articles are selected and recommended from each cluster based on their reputation ranks.}, language = {en} } @article{WandHolzloehnerNeupertetal.2011, author = {Wand, Inga and Holzl{\"o}hner, Pamela and Neupert, Steffi and Micheel, Burkhard and Heilmann, Katja}, title = {Cooperation of dendritic cells with naive lymphocyte populations to induce the generation of antigen-specific antibodies in vitro}, series = {Journal of biotechnology}, volume = {156}, journal = {Journal of biotechnology}, number = {3}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0168-1656}, doi = {10.1016/j.jbiotec.2011.09.002}, pages = {173 -- 181}, year = {2011}, abstract = {The production of monoclonal antibodies by hybridoma technology is dependent on lymphocytes taken from vertebrates which have to be immunized against the corresponding antigen. We present here our first experiments which should allow the replacement of this in vivo immunization step by an in vitro immunization procedure. This work provides new possibilities for the specific activation of immune cells in order to use them for the generation of antibodies which are not of murine origin. Bone marrow-derived dendritic cells were loaded with antigen and co-cultured with naive T and B lymphocytes of non-immunized mice. The interaction and activation of the different cell types were investigated by measuring the expression of specific cell surface markers, the release of activation-dependent interleukins and the secretion of antigen-specific antibodies. We could demonstrate that dendritic cells process and present antigen fragments and activate T cells, that T cells proliferate and release activation-induced interleukins, and that B cells maturate under the influence of activated T cells and secrete antigen-specific antibodies.}, language = {en} } @unpublished{WalzAdrianGilbertetal.2011, author = {Walz, Norbert and Adrian, Rita and Gilbert, John J. and Monaghan, Michael T. and Weithoff, Guntram and Zimmermann-Timm, Heike}, title = {Preface}, series = {Hydrobiologia : acta hydrobiologica, hydrographica, limnologica et protistologica}, volume = {662}, journal = {Hydrobiologia : acta hydrobiologica, hydrographica, limnologica et protistologica}, number = {1}, publisher = {Springer}, address = {Dordrecht}, issn = {0018-8158}, doi = {10.1007/s10750-010-0514-2}, pages = {1 -- 4}, year = {2011}, language = {en} } @article{WagnerAntunesRistowetal.2011, author = {Wagner, Viktoria and Antunes, Pedro M. and Ristow, Michael and Lechner, Ute and Hensen, Isabell}, title = {Prevailing negative soil biota effect and no evidence for local adaptation in a widespread eurasian grass}, series = {PLoS one}, volume = {6}, journal = {PLoS one}, number = {3}, publisher = {PLoS}, address = {San Fransisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0017580}, pages = {8}, year = {2011}, abstract = {Background: Soil biota effects are increasingly accepted as an important driver of the abundance and distribution of plants. While biogeographical studies on alien invasive plant species have indicated coevolution with soil biota in their native distribution range, it is unknown whether adaptation to soil biota varies among populations within the native distribution range. The question of local adaptation between plants and their soil biota has important implications for conservation of biodiversity and may justify the use of seed material from local provenances in restoration campaigns. Methodology/Principal Findings: We studied soil biota effects in ten populations of the steppe grass Stipa capillata from two distinct regions, Europe and Asia. We tested for local adaptation at two different scales, both within (ca. 10-80 km) and between (ca. 3300 km) regions, using a reciprocal inoculation experiment in the greenhouse for nine months. Generally, negative soil biota effects were consistent. However, we did not find evidence for local adaptation: both within and between regions, growth of plants in their 'home soil' was not significantly larger relative to that in soil from other, more distant, populations. Conclusions/Significance: Our study suggests that negative soil biota effects can prevail in different parts of a plant species' range. Absence of local adaptation points to the possibility of similar rhizosphere biota composition across populations and regions, sufficient gene flow to prevent coevolution, selection in favor of plasticity, or functional redundancy among different soil biota. From the point of view of plant - soil biota interactions, our findings indicate that the current practice of using seeds exclusively from local provenances in ecosystem restoration campaigns may not be justified.}, language = {en} } @misc{WagnerPywellKnoppetal.2011, author = {Wagner, Markus and Pywell, Richard F. and Knopp, Tatjana and Bullock, James M. and Heard, Matthew S.}, title = {The germination niches of grassland species targeted for restoration}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe}, number = {675}, issn = {1866-8372}, doi = {10.25932/publishup-41343}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-413438}, pages = {117 -- 131}, year = {2011}, abstract = {Restoration of semi-natural grassland communities involves a combination of (1) sward disturbance to create a temporal window for establishment, and (2) target species introduction, the latter usually by seed sowing. With great regularity, particular species establish only poorly. More reliable establishment could improve outcome of restoration projects and increase cost-effectiveness. We investigated the abiotic germination niche of ten poorly establishing calcareous grassland species by simultaneously exploring the effects of moisture and light availability and temperature fluctuation on percentage germina- tion and speed of germination. We also investigated the effects of three different pre-treatments used to enhance seed germination - cold-stratification, osmo- tic priming and priming in combination with gibberellic acid (GA 3 ) - and how these affected abiotic germination niches. Species varied markedly in width of abiotic germination niche, ranging from Carex flacca with very strict abiotic requirements, to several species reliably germinating across the whole range of abiotic conditions. Our results suggest pronounced differ- ences between species in gap requirements for establishment. Germination was improved in most species by at least one pre-treatment. Evidence for positive effects of adding GA 3 to seed priming solutions was limited. In several species, pre-treated seeds germinated under a wider range of abiotic conditions than untreated seeds. Improved knowledge of species-specific germination niches and the effects of seed pre-treatments may help to improve species establishment by sowing, and to identify species for which sowing at a later stage of restoration or introduction as small plants may represent a more viable strategy.}, language = {en} } @article{Wagner2011, author = {Wagner, Birgitt}, title = {J{\"u}dische Gesellschaft im Mittelpunkt}, series = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien e.V.}, journal = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien e.V.}, number = {17}, issn = {1614-6492}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-53246}, pages = {53 -- 70}, year = {2011}, abstract = {Dieser Text geht der Frage nach, wie die wissenschaftliche Auseinandersetzung mit den nationalsozialistischen Ghettos in der Zeit von 1945 bis 1960 im englischen Sprachraum betrieben wurde. Werke, die j{\"u}disches Erleben und Handeln mitsamt der gesellschaftlichen Organisation in den Mittelpunkt r{\"u}cken, sind in diesem Zeitraum deutlich st{\"a}rker vertreten, als dies nach einer Lekt{\"u}re der Sekund{\"a}rliteratur zu erwarten w{\"a}re. Ein wissenschaftlicher Ansatz, der die Juden nicht nur als namenlose Masse von Opfern wahrnimmt, tritt also durchaus schon fr{\"u}h auf. Ebenso wird die Politik der j{\"u}dischen F{\"u}hrungsschichten, der so genannten ‚Judenr{\"a}te', deutlich differenzierter verhandelt als vermutet; neben vernichtenden Urteilen finden sich Kontextualisierungen, die ihr Agieren aus verschiedenen Blickwinkeln beleuchten und einordnen. Auch wenn diese Forschungsanliegen zun{\"a}chst nur bedingt rezipiert wurden und vor allem universit{\"a}r marginal blieben, lassen sich doch von dieser Seite Traditionslinien besonders in die entstehende israelische Holocaustforschung beobachten.}, language = {de} } @phdthesis{Voelker2011, author = {V{\"o}lker, Jan}, title = {{\"A}sthetik der Lebendigkeit : Kants dritte Kritik}, publisher = {Fink}, address = {Paderborn}, isbn = {978-3-7705-5161-3}, pages = {274 S.}, year = {2011}, language = {de} } @phdthesis{Vapenka2011, author = {V{\´a}penka, Aleš}, title = {Geschlechterstereotype und Geschlechtsidentit{\"a}t von M{\"a}nnern mit unterschiedlichem Verlauf der psychosexuellen Entwicklung}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-53175}, school = {Universit{\"a}t Potsdam}, year = {2011}, abstract = {Im Rahmen eines explorativen Vergleichsuntersuchungsplans wurde untersucht, inwieweit sich die durch biologische Faktoren bedingte unterschiedliche Lebenserfahrung sowie die Sozialisationsbedingungen in der psychosexuellen Entwicklung bei hetero-, homo- und postoperativen transsexuellen M{\"a}nnern (N = 191) auf die Integration der Geschlechterstereotypen in die kognitiven (Selbst-, Fremdwahrnehmung), emotionalen (Selbst- und Fremdbewertung) und verhaltensm{\"a}ßigen Aspekte (Normen der geschlechtsspezifischen Verhaltens) der Geschlechtsidentit{\"a}t auswirken und ob sich Identifikationsmuster der Entwicklung des geschlechtlichen Selbstkonzepts ableiten lassen. Die Messung der kognitiven Aspekte des geschlechtlichen Selbstkonzepts (Maskulinit{\"a}t und Femininit{\"a}t) erfolgte mittels der GERO-Skala von Brengelmann und Hendrich (1990). Zur Erfassung der emotionalen Aspekte und Identifikationsmuster der Entwicklung des geschlechtlichen Selbstkonzepts wurden die Werte f{\"u}r die Variablen Maskulinit{\"a}t und Femininit{\"a}t zuerst mittels der computergesteuerten Methodik IDEXMONO und IDEXIDIO, die auf der Identit{\"a}tsstrukturanalyse (Identity Structure Analysis) von Weinreich (2003) basiert, aufgearbeitet und weiter interferenzstatistisch ausgewertet. Weiterhin wurden der Fragebogen zur Messung normativer Geschlechtsrollenorientierung (NGRO) von Athenstaedt (2000) sowie ein ad hoc entworfener demographischer Fragebogen eingesetzt. Die Ergebnisse zeigen, dass der Verlauf der psychosexuellen Entwicklung einen starken Einfluss auf die Integration der Geschlechterstereotypen in die geschlechtliche Selbst- und Fremdwahrnehmung hat. Im kognitiven Bereich, bezogen auf die pers{\"o}nliche Identit{\"a}t (Grad der Selbstzuschreibung m{\"a}nnlicher und weiblicher Merkmale), stellt die Maskulinit{\"a}t eine stabile und erstrebenswerte Variable zur Herausbildung des geschlechtlichen Selbstkonzepts bei allen Gruppen dar. Die Femininit{\"a}t tr{\"a}gt am meisten zur Differenzierung zwischen den Hetero-, Homo- und Transsexuellen bei. Sie wird, je nach der Entwicklungsphase, unterschiedlich in das geschlechtliche Selbstkonzept integriert. Hinsichtlich der sozialen Identit{\"a}t (Zugeh{\"o}rigkeitsgef{\"u}hl) lassen sich die Gruppen bez{\"u}glich der wahrgenommenen {\"A}hnlichkeiten sowohl mit m{\"a}nnlichen als auch weiblichen Personen, je nach der Entwicklungsphase, unterscheiden. Die soziale Wahrnehmung von M{\"a}nnern und Frauen (Fremdwahrnehmung), ist bei Transsexuellen traditioneller als die der Hetero- und Homosexuellen. Bei der Selbst- und Fremdbewertung ergaben sich keine signifikanten Unterschiede. Bei der Internalisierung der sozialen Normen des geschlechtsspezifischen Verhaltens zeigt sich, dass Heterosexuelle der Aus{\"u}bung der Geschlechterrollen gegen{\"u}ber egalit{\"a}rer eingestellt sind als Trans- und Homosexuelle. Bei den Sozialisationsfaktoren ist hervorzuheben, dass generell weibliche Identifikationspersonen einen st{\"a}rkeren Einfluss auf die Herausbildung des geschlechtlichen Selbstkonzeptes hatten als m{\"a}nnliche Identifikationspersonen. Es scheint jedoch, dass Homosexuelle bei der Entwicklung ihres geschlechtlichen Selbstkonzepts st{\"a}rker unter dem Einfluss der Frauen stehen als die anderen zwei erforschten Gruppen. Zur Beantwortung der Frage, welche selbstkonzeptbezogenen Variablen und Entwicklungsfaktoren die gr{\"o}ßte statistische Bedeutung f{\"u}r die Trennung und Pr{\"a}diktion der einzelnen untersuchten Gruppen haben, wurde eine Diskriminanzanalyse berechnet. Die gr{\"o}ßte diskriminatorische Bedeutung besitzen die Variablen „Stereotypische Wahrnehmung der m{\"a}nnlichen Personen" und „Ego-Involvement mit weiblichen Personen" f{\"u}r die Diskriminanzfunktion 1 (Trennung der Transsexuellen von Hetero- und Homosexuellen) und die Variablen „Empathische Identifikation mit m{\"a}nnlichen Personen in der Vergangenheit" und „Zuwachs an empathischer Identifikation mit weiblichen Personen" f{\"u}r die Diskriminanzfunktion 2 (Trennung der Hetero- von Homosexuellen).}, language = {de} } @inproceedings{VukicevicSchreiberBeuermann2011, author = {Vukicevic, Radovan and Schreiber, Ulrike and Beuermann, Sabine}, title = {Azide-terminated poly(vinylidene fluoride) as building block for nanocomposite materials and block copolymers}, series = {Abstracts of papers : joint conference / The Chemical Institute of Cananda, CIC, American Chemical Society, ACS}, volume = {242}, booktitle = {Abstracts of papers : joint conference / The Chemical Institute of Cananda, CIC, American Chemical Society, ACS}, number = {16}, publisher = {American Chemical Society}, address = {Washington}, issn = {0065-7727}, pages = {1}, year = {2011}, language = {en} } @article{VukicevicBeuermann2011, author = {Vukicevic, Radovan and Beuermann, Sabine}, title = {Fullerenes decorated with poly(vinylidene fluoride)}, series = {Macromolecules : a publication of the American Chemical Society}, volume = {44}, journal = {Macromolecules : a publication of the American Chemical Society}, number = {8}, publisher = {American Chemical Society}, address = {Washington}, issn = {0024-9297}, doi = {10.1021/ma102754c}, pages = {2597 -- 2603}, year = {2011}, abstract = {Fullerenes decorated with poly(vinylidene fluoride) (PVDF) were synthesized in a three-step procedure: Iodine transfer polymerization of vinylidene fluoride with C(6)F(12)I(2) as the chain transfer agent was carried out in supercritical carbon dioxide to synthesize iodine-terminated PVDF, which was subsequently transformed to azide-terminated polymer. Finally, azide-terminated PVDF chains were attached to a fullerene core under microwave irradiation at 160 degrees C in 1.5 h. The materials were characterized by NMR, FT-IR, UV/vis, GPC, elemental analysis, and DSC. On average, 4-5 PVDF chains are attached to one C(60) moiety. FT-IR spectra and DSC measurements indicate that the polymer end groups strongly affect the crystallinity of the material. For PVDF with azide end groups and PVDF attached to fullerenes the fraction of the beta polymorph is dominant while alpha polymorphs are almost absent.}, language = {en} } @phdthesis{Vukicevic2011, author = {Vukicevic, Radovan}, title = {Iodine- and azide-terminated poly(vinylidene fluoride) as a building block for the preparation of hybrid materials and block copolymers}, address = {Potsdam}, pages = {122 S.}, year = {2011}, language = {en} } @article{VossNimtzLeimkuehler2011, author = {Voss, Martin and Nimtz, Manfred and Leimk{\"u}hler, Silke}, title = {Elucidation of the dual role of Mycobacterial MoeZR in Molybdenum Cofactor Biosynthesis and Cysteine Biosynthesis}, series = {PLoS one}, volume = {6}, journal = {PLoS one}, number = {11}, publisher = {PLoS}, address = {San Fransisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0028170}, pages = {9}, year = {2011}, abstract = {The pathway of molybdenum cofactor biosynthesis has been studied in detail by using proteins from Mycobacterium species, which contain several homologs associated with the first steps of Moco biosynthesis. While all Mycobacteria species contain a MoeZR, only some strains have acquired an additional homolog, MoeBR, by horizontal gene transfer. The role of MoeBR and MoeZR was studied in detail for the interaction with the two MoaD-homologs involved in Moco biosynthesis, MoaD1 and MoaD2, in addition to the CysO protein involved in cysteine biosynthesis. We show that both proteins have a role in Moco biosynthesis, while only MoeZR, but not MoeBR, has an additional role in cysteine biosynthesis. MoeZR and MoeBR were able to complement an E. coli moeB mutant strain, but only in conjunction with the Mycobacterial MoaD1 or MoaD2 proteins. Both proteins were able to sulfurate MoaD1 and MoaD2 in vivo, while only MoeZR additionally transferred the sulfur to CysO. Our in vivo studies show that Mycobacteria have acquired several homologs to maintain Moco biosynthesis. MoeZR has a dual role in Moco- and cysteine biosynthesis and is involved in the sulfuration of MoaD and CysO, whereas MoeBR only has a role in Moco biosynthesis, which is not an essential function for Mycobacteria.}, language = {en} } @phdthesis{Vosloh2011, author = {Vosloh, Daniel}, title = {Subcellular compartmentation of primary carbon metabolism in mesophyll cells of Arabidopsis thaliana}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-55534}, school = {Universit{\"a}t Potsdam}, year = {2011}, abstract = {Metabolismus in Pflanzenzellen ist stark kompartimentiert. Viele Stoffwechselwege haben Reaktionen in mehr als einem Kompartiment. Zum Beispiel wird w{\"a}hrend der Photosynthese in pflanzlichen Mesophyllzellen Kohlenstoff in Form von St{\"a}rke in den Chloroplasten synthetisiert, w{\"a}hrend es im Zytosol in Form von Sacharose gebildet und in der Vakuole gespeichert wird. Diese Reaktionen sind strikt reguliert um ein Gleichgewicht der Kohlenstoffpools der verschiedenen Kompartimente aufrecht zu erhalten und die Energieversorgung aller Teile der Zelle f{\"u}r anabolische Reaktionen sicher zu stellen. Ich wende eine Methode an, bei der die Zellen unter nicht-w{\"a}ssrigen Bedingungen fraktioniert werden und daher der metabolische Status der w{\"a}hrend der Ernte herrschte {\"u}ber den ganzen Zeitraum der Auftrennung beibehalten wird. Durch die Kombination von nichtw{\"a}ssriger Fraktionierung und verschiedener Massenspektrometrietechniken (Fl{\"u}ssigchromotagraphie- und Gaschromotagraphie basierende Massenspekrometrie) ist es m{\"o}glich die intrazellul{\"a}re Verteilung der meisten Intermediate des photosynthetischen Kohlenstoffstoffwechsels und der Produkte der nachgelagerten metabolischen Reaktionen zu bestimmen. Das Wissen {\"u}ber die in vivo Konzentrationen dieser Metabolite wurde genutzt um die {\"A}nderung der freien Gibbs Energie in vivo zu bestimmen. Mit Hilfe dessen kann bestimmt werden, welche Reaktion sich in einem Gleichgewichtszustand befinden und welche davon entfernt sind. Die Konzentration der Enzyme und der Km Werte wurden mit den Konzentrationen der Metabolite in vivo verglichen, um festzustellen, welche Enzyme substratlimitiert sind und somit sensitiv gegen{\"u}ber {\"A}nderungen der Substratkonzentration sind. Verschiedene Intermediate des Calvin-Benson Zyklus sind gleichzeitig Substrate f{\"u}r andere Stoffwechselwege, als da w{\"a}ren Dihyroxyaceton-phosphat (DHAP, Saccharosesynthese), Fructose 6-phosphat (Fru6P, St{\"a}rkesynthese), Erythrose 4-phosphat (E4P, Shikimat Stoffwechselweg) und Ribose 5-phosphat (R5P, Nukleotidbiosynthese). Die Enzyme, die diese Intermediate verstoffwechseln, liegen an den Abzweigungspunkten zu diesen Stoffwechselwegen. Diese sind Trisose phosphat isomerase (DHAP), Transketolase (E4P), Sedoheptulose-1,7 biphosphat aldolase (E4P) und Ribose-5-phosphat isomerase (R5P), welche nicht mit ihren Substraten ges{\"a}ttigt sind, da die jeweilige Substratkonzentration geringer als der zugeh{\"o}rige Km Wert ist. F{\"u}r metabolische Kontrolle bedeutet dies, dass diese Schritte am sensitivsten gegen{\"u}ber {\"A}nderungen der Substratkonzentrationen sind. Im Gegensatz dazu sind die regulierten irreversiblen Schritte von Fructose-1,6.biphosphatase und Sedoheptulose-1,7-biphosphatase relativ insensitiv gegen{\"u}ber {\"A}nderungen der Substratkonzentration. F{\"u}r den Stoffwechselweg der Saccharosesynthese konnte gezeigt werden, dass die zytosolische Aldolase eine geringer Bindeseitenkonzentration als Substratkonzentration (DHAP) aufweist, und dass die Konzentration von Saccharose-6-phosphat geringer als der Km Wert des synthetisierenden Enzyms Saccharose-phosphatase ist. Sowohl die Saccharose-phosphat-synthase, also auch die Saccharose-phosphatase sind in vivo weit von einem Gleichgewichtszustand entfernt. In Wildtyp Arabidopsis thaliana Columbia-0 Bl{\"a}ttern wurde der gesamte Pool von ADPGlc im Chloroplasten gefunden. Das Enzyme ADPGlc pyrophosphorylase ist im Chloroplasten lokalisiert und synthetisiert ADPGlc aus ATP und Glc1P. Dieses Verteilungsmuster spricht eindeutig gegen die Hypothese von Pozueta-Romero und Kollegen, dass ADPGlc im Zytosol durch ADP vermittelte Spaltung von Saccharose durch die Saccharose Synthase erzeugt wird. Basierend auf dieser Beobachtung und anderen ver{\"o}ffentlichten Ergebnissen wurde geschlußfolgert, dass der generell akzeptierte Stoffwechselweg der St{\"a}rkesynthese durch ADPGlc Produktion via ADPGlc pyrophosphorylase in den Chloroplasten korrekt ist, und die Hypothese des alternativen Stoffwechselweges unhaltbar ist. Innerhalb des Stoffwechselweges der Saccharosesynthsese wurde festgestellt, dass die Konzentration von ADPGlc geringer als der Km Wert des St{\"a}rkesynthase ist, was darauf hindeutet, dass das Enzym substratlimitiert ist. Eine generelle Beobachtung ist, dass viele Enzmye des Calvin-Benson Zyklus {\"a}hnliche Bindeseitenkonzentrationen wie Metabolitkonzentrationen aufweisen, wohingegen in den Synthesewegen von Saccharose und St{\"a}rke die Bindeseitenkonzentrationen der Enzyme viel geringer als die Metabolitkonzentrationen sind.}, language = {en} } @phdthesis{vonNicolai2011, author = {von Nicolai, Christina}, title = {The interplay of salt movements and regional tectonics at the passive continental margin of the South Atlantic, Kwanza Basin}, address = {Potsdam}, pages = {134 S.}, year = {2011}, language = {en} } @article{vonKleistMenzStockeretal.2011, author = {von Kleist, Max and Menz, Stephan and Stocker, Hartmut and Arasteh, Keikawus and Schuette, Christof and Huisinga, Wilhelm}, title = {HIV quasispecies dynamics during pro-active treatment switching impact on multi-drug resistance and resistance archiving in latent reservoirs}, series = {PLoS one}, volume = {6}, journal = {PLoS one}, number = {3}, publisher = {PLoS}, address = {San Fransisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0018204}, pages = {12}, year = {2011}, abstract = {The human immunodeficiency virus (HIV) can be suppressed by highly active anti-retroviral therapy (HAART) in the majority of infected patients. Nevertheless, treatment interruptions inevitably result in viral rebounds from persistent, latently infected cells, necessitating lifelong treatment. Virological failure due to resistance development is a frequent event and the major threat to treatment success. Currently, it is recommended to change treatment after the confirmation of virological failure. However, at the moment virological failure is detected, drug resistant mutants already replicate in great numbers. They infect numerous cells, many of which will turn into latently infected cells. This pool of cells represents an archive of resistance, which has the potential of limiting future treatment options. The objective of this study was to design a treatment strategy for treatment-naive patients that decreases the likelihood of early treatment failure and preserves future treatment options. We propose to apply a single, pro-active treatment switch, following a period of treatment with an induction regimen. The main goal of the induction regimen is to decrease the abundance of randomly generated mutants that confer resistance to the maintenance regimen, thereby increasing subsequent treatment success. Treatment is switched before the overgrowth and archiving of mutant strains that carry resistance against the induction regimen and would limit its future re-use. In silico modelling shows that an optimal trade-off is achieved by switching treatment at \& 80 days after the initiation of antiviral therapy. Evaluation of the proposed treatment strategy demonstrated significant improvements in terms of resistance archiving and virological response, as compared to conventional HAART. While continuous pro-active treatment alternation improved the clinical outcome in a randomized trial, our results indicate that a similar improvement might also be reached after a single pro-active treatment switch. The clinical validity of this finding, however, remains to be shown by a corresponding trial.}, language = {en} } @misc{vonHumboldt2011, author = {von Humboldt, Alexander}, title = {Zenralamerika}, publisher = {Univ.}, address = {San jose}, pages = {119 S.}, year = {2011}, language = {de} }