@misc{Şener2017, author = {Şener, Ula{\c{s}}}, title = {Rodrik, Dani (2015): Economics Rules: The Rights and Wrongs of the Dismal Science / rezensiert von Ula{\c{s}} Şener}, series = {European journal of economics and economic policies : intervention ; EJEEP}, volume = {14}, journal = {European journal of economics and economic policies : intervention ; EJEEP}, publisher = {Elgar}, address = {Cheltenham}, issn = {2052-7764}, doi = {10.4337/ejeep.2017.03.08}, pages = {375 -- 377}, year = {2017}, language = {en} } @misc{YarmanJetzschmannNeumannetal.2017, author = {Yarman, Aysu and Jetzschmann, Katharina J. and Neumann, Bettina and Zhang, Xiaorong and Wollenberger, Ulla and Cordin, Aude and Haupt, Karsten and Scheller, Frieder W.}, title = {Enzymes as Tools in MIP-Sensors}, series = {Chemosensors}, volume = {5}, journal = {Chemosensors}, publisher = {MDPI}, address = {Basel}, issn = {2227-9040}, doi = {10.3390/chemosensors5020011}, pages = {16}, year = {2017}, abstract = {Molecularly imprinted polymers (MIPs) have the potential to complement antibodies in bioanalysis, are more stable under harsh conditions, and are potentially cheaper to produce. However, the affinity and especially the selectivity of MIPs are in general lower than those of their biological pendants. Enzymes are useful tools for the preparation of MIPs for both low and high-molecular weight targets: As a green alternative to the well-established methods of chemical polymerization, enzyme-initiated polymerization has been introduced and the removal of protein templates by proteases has been successfully applied. Furthermore, MIPs have been coupled with enzymes in order to enhance the analytical performance of biomimetic sensors: Enzymes have been used in MIP-sensors as tracers for the generation and amplification of the measuring signal. In addition, enzymatic pretreatment of an analyte can extend the analyte spectrum and eliminate interferences.}, language = {en} } @misc{YangDarkoHuangetal.2017, author = {Yang, Xiaoping and Darko, Kwame Oteng and Huang, Yanjun and He, Caimei and Yang, Huansheng and He, Shanping and Li, Jianzhong and Li, Jian and Hocher, Berthold and Yin, Yulong}, title = {Resistant starch regulates gut microbiota}, series = {Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology}, volume = {42}, journal = {Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology}, number = {1}, publisher = {Karger}, address = {Basel}, issn = {1015-8987}, doi = {10.1159/000477386}, pages = {306 -- 318}, year = {2017}, abstract = {Starch is one of the most popular nutritional sources for both human and animals. Due to the variation of its nutritional traits and biochemical specificities, starch has been classified into rapidly digestible, slowly digestible and resistant starch. Resistant starch has its own unique chemical structure, and various forms of resistant starch are commercially available. It has been found being a multiple-functional regulator for treating metabolic dysfunction. Different functions of resistant starch such as modulation of the gut microbiota, gut peptides, circulating growth factors, circulating inflammatory mediators have been characterized by animal studies and clinical trials. In this mini-review, recent remarkable progress in resistant starch on gut microbiota, particularly the effect of structure, biochemistry and cell signaling on nutrition has been summarized, with highlights on its regulatory effect on gut microbiota.}, language = {en} } @misc{WiesnerReinholdSchreinerBaldermannetal.2017, author = {Wiesner-Reinhold, Melanie and Schreiner, Monika and Baldermann, Susanne and Schwarz, Dietmar and Hanschen, Franziska S. and Kipp, Anna Patricia and Rowan, Daryl D. and Bentley-Hewitt, Kerry L. and McKenzie, Marian J.}, title = {Mechanisms of Selenium Enrichment and Measurement in Brassicaceous Vegetables, and Their Application to Human Health}, series = {Frontiers in plant science}, volume = {8}, journal = {Frontiers in plant science}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-462X}, doi = {10.3389/fpls.2017.01365}, pages = {20}, year = {2017}, abstract = {Selenium (Se) is an essential micronutrient for human health. Se deficiency affects hundreds of millions of people worldwide, particularly in developing countries, and there is increasing awareness that suboptimal supply of Se can also negatively affect human health. Selenium enters the diet primarily through the ingestion of plant and animal products. Although, plants are not dependent on Se they take it up from the soil through the sulphur (S) uptake and assimilation pathways. Therefore, geographic differences in the availability of soil Se and agricultural practices have a profound influence on the Se content of many foods, and there are increasing efforts to biofortify crop plants with Se. Plants from the Brassicales are of particular interest as they accumulate and synthesize Se into forms with additional health benefits, such as methylselenocysteine (MeSeCys). The Brassicaceae are also well-known to produce the glucosinolates; S-containing compounds with demonstrated human health value. Furthermore, the recent discovery of the selenoglucosinolates in the Brassicaceae raises questions regarding their potential bioefficacy. In this review we focus on Se uptake and metabolism in the Brassicaceae in the context of human health, particularly cancer prevention and immunity. We investigate the close relationship between Se and S metabolism in this plant family, with particular emphasis on the selenoglucosinolates, and consider the methodologies available for identifying and quantifying further novel Se-containing compounds in plants. Finally, we summarize the research of multiple groups investigating biofortification of the Brassicaceae and discuss which approaches might be most successful for supplying Se deficient populations in the future.}, language = {en} } @misc{WickLeegerAschmannMonnetal.2017, author = {Wick, Kristin and Leeger-Aschmann, Claudia S. and Monn, Nico D. and Radtke, Thomas and Ott, Laura V. and Rebholz, Cornelia E. and Cruz, Sergio and Gerber, Natalie and Schmutz, Einat A. and Puder, Jardena J. and Munsch, Simone and Kakebeeke, Tanja H. and Jenni, Oskar G. and Granacher, Urs and Kriemler, Susi}, title = {Interventions to Promote Fundamental Movement Skills in Childcare and Kindergarten: A Systematic Review and Meta-Analysis}, series = {Sports medicine}, volume = {47}, journal = {Sports medicine}, publisher = {Springer}, address = {Northcote}, issn = {0112-1642}, doi = {10.1007/s40279-017-0723-1}, pages = {2045 -- 2068}, year = {2017}, abstract = {Background Proficiency in fundamental movement skills (FMS) lays the foundation for being physically active and developing more complex motor skills. Improving these motor skills may provide enhanced opportunities for the development of a variety of perceptual, social, and cognitive skills. Objective The objective of this systematic review and meta-analysis was to assess the effects of FMS interventions on actual FMS, targeting typically developing young children. Method Searches in seven databases (CINAHL, Embase, MEDLINE, PsycINFO, PubMed, Scopus, Web of Science) up to August 2015 were completed. Trials with children (aged 2-6 years) in childcare or kindergarten settings that applied FMS-enhancing intervention programs of at least 4 weeks and meeting the inclusion criteria were included. Standardized data extraction forms were used. Risk of bias was assessed using a standard scoring scheme (Effective Public Health Practice Project-Quality Assessment Tool for Quantitative Studies [EPHPP]). We calculated effects on overall FMS, object control and locomotor subscales (OCS and LMS) by weighted standardized mean differences (SMDbetween) using random-effects models. Certainty in training effects was evaluated using GRADE (Grading of Recommendations Assessment, Development, and Evaluation System). Results Thirty trials (15 randomized controlled trials and 15 controlled trials) involving 6126 preschoolers (aged 3.3-5.5 years) revealed significant differences among groups in favor of the intervention group (INT) with small-to-large effects on overall FMS (SMDbetween 0.46), OCS (SMDbetween 1.36), and LMS (SMDbetween 0.94). Our certainty in the treatment estimates based on GRADE is very low. Conclusions Although there is relevant effectiveness of programs to improve FMS proficiency in healthy young children, they need to be interpreted with care as they are based on low-quality evidence and immediate post-intervention effects without long-term follow-up.}, language = {en} } @misc{Weiss2017, author = {Weiß, Norman}, title = {Claudio Franzius/Franz C. Mayer/J{\"u}rgen Meyer (Hrsg.), Modelle des Parlamentarismus im 21. Jahrhundert. Neue Ordnungen von Recht und Politik / [rezensiert von] Norman Weiß}, series = {MenschenRechtsMagazin : MRM ; Informationen, Meinungen, Analysen}, volume = {22}, journal = {MenschenRechtsMagazin : MRM ; Informationen, Meinungen, Analysen}, number = {1}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1434-2820}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-405455}, pages = {80 -- 81}, year = {2017}, language = {de} } @misc{vanderLubbeKrauseNehringJungingeretal.2017, author = {van der Lubbe, H. J. L. and Krause-Nehring, J. and Junginger, A. and Garcin, Yannick and Joordens, J. C. A. and Davies, G. R. and Beck, C. and Feibel, C. S. and Johnson, T. C. and Vonhof, H. B.}, title = {Gradual or abrupt? Changes in water source of Lake Turkana (Kenya) during the African Humid Period inferred from Sr isotope ratios}, series = {Quaternary science reviews : the international multidisciplinary research and review journal}, volume = {174}, journal = {Quaternary science reviews : the international multidisciplinary research and review journal}, publisher = {Elsevier}, address = {Oxford}, issn = {0277-3791}, doi = {10.1016/j.quascirev.2017.08.010}, pages = {1 -- 12}, year = {2017}, language = {en} } @misc{Temmen2017, author = {Temmen, Jens}, title = {The Unsettlement of America: Translation, Interpretation, and the Story of Don Luis de Velasco, 1560-1945}, series = {Zeitschrift f{\"u}r Anglistik und Amerikanistik : a quarterly of language, literature and cultur}, volume = {65}, journal = {Zeitschrift f{\"u}r Anglistik und Amerikanistik : a quarterly of language, literature and cultur}, number = {1}, publisher = {De Gruyter}, address = {Berlin}, issn = {0044-2305}, doi = {10.1515/zaa-2017-0011}, pages = {117 -- 119}, year = {2017}, language = {en} } @misc{SubettoNazarovaPestryakovaetal.2017, author = {Subetto, D. A. and Nazarova, Larisa B. and Pestryakova, Luidmila Agafyevna and Syrykh, Liudmila and Andronikov, A. V. and Biskaborn, B. and Diekmann, Bernhard and Kuznetsov, D. D. and Sapelko, T. V. and Grekov, I. M.}, title = {Paleolimnological studies in Russian northern Eurasia}, series = {Contemporary Problems of Ecology}, volume = {10}, journal = {Contemporary Problems of Ecology}, publisher = {Pleiades Publ.}, address = {New York}, issn = {1995-4255}, doi = {10.1134/S1995425517040102}, pages = {327 -- 335}, year = {2017}, abstract = {This article presents a review of the current data on the level of paleolimnological knowledge about lakes in the Russian part of the northern Eurasia. The results of investigation of the northwestern European part of Russia as the best paleolimnologically studied sector of the Russian north is presented in detail. The conditions of lacustrine sedimentation at the boundary between the Late Pleistocene and Holocene and the role of different external factors in formation of their chemical composition, including active volcanic activity and possible large meteorite impacts, are also discussed. The results of major paleoclimatic and paleoecological reconstructions in northern Siberia are presented. Particular attention is given to the databases of abiotic and biotic parameters of lake ecosystems as an important basis for quantitative reconstructions of climatic and ecological changes in the Late Pleistocene and Holocene. Keywords: paleolimnology, lakes, bottom sediments, northern.}, language = {en} } @misc{Spahn2017, author = {Spahn, Hannah}, title = {Rezension zu: Helo, Ari, Thomas Jefferson's ethics and the politics of human progress: the morality of a slaveholder. - New York, NY: Cambridge Univ. Press, 2014. - ISBN 978-1-107-04078-6}, series = {Journal of the Early Republic}, volume = {37}, journal = {Journal of the Early Republic}, number = {1}, publisher = {University of Pennsylvania Press}, address = {Philadelphia}, issn = {0275-1275}, doi = {10.1353/jer.2017.0010}, pages = {170 -- 173}, year = {2017}, language = {en} } @misc{ShpritsAngelopoulosRusselletal.2017, author = {Shprits, Yuri Y. and Angelopoulos, V. and Russell, C. T. and Strangeway, R. J. and Runov, A. and Turner, D. and Caron, R. and Cruce, P. and Leneman, D. and Michaelis, I. and Petrov, V. and Panasyuk, M. and Yashin, I. and Drozdov, Alexander and Russell, C. L. and Kalegaev, V. and Nazarkov, I. and Clemmons, J. H.}, title = {Scientific Objectives of Electron Losses and Fields INvestigation Onboard Lomonosov Satellite}, series = {Space science reviews}, volume = {214}, journal = {Space science reviews}, number = {1}, publisher = {Springer}, address = {Dordrecht}, issn = {0038-6308}, doi = {10.1007/s11214-017-0455-4}, pages = {19}, year = {2017}, abstract = {The objective of the Electron Losses and Fields INvestigation on board the Lomonosov satellite ( ELFIN-L) project is to determine the energy spectrum of precipitating energetic electrons and ions and, together with other polar-orbiting and equatorial missions, to better understand the mechanisms responsible for scattering these particles into the atmosphere. This mission will provide detailed measurements of the radiation environment at low altitudes. The 400-500 km sun-synchronous orbit of Lomonosov is ideal for observing electrons and ions precipitating into the atmosphere. This mission provides a unique opportunity to test the instruments. Similar suite of instruments will be flown in the future NSF-and NASA-supported spinning CubeSat ELFIN satellites which will augment current measurements by providing detailed information on pitch-angle distributions of precipitating and trapped particles.}, language = {en} } @misc{ShlapunovTarkhanov2017, author = {Shlapunov, Alexander and Tarkhanov, Nikolai Nikolaevich}, title = {Golusin-Krylov formulas in complex analysis}, series = {Complex variables and elliptic equations}, volume = {63}, journal = {Complex variables and elliptic equations}, number = {7-8}, publisher = {Routledge}, address = {Abingdon}, issn = {1747-6933}, doi = {10.1080/17476933.2017.1395872}, pages = {1142 -- 1167}, year = {2017}, abstract = {This is a brief survey of a constructive technique of analytic continuation related to an explicit integral formula of Golusin and Krylov (1933). It goes far beyond complex analysis and applies to the Cauchy problem for elliptic partial differential equations as well. As started in the classical papers, the technique is elaborated in generalised Hardy spaces also called Hardy-Smirnov spaces.}, language = {en} } @misc{SernoWincklerAndersonetal.2017, author = {Serno, Sascha and Winckler, Gisela and Anderson, Robert F. and Jaccard, Samuel L. and Kienast, Stephanie S. and Haug, Gerald H.}, title = {Change in dust seasonality as the primary driver for orbital-scale dust storm variability in East Asia}, series = {Geophysical research letters}, volume = {44}, journal = {Geophysical research letters}, publisher = {American Geophysical Union}, address = {Washington}, issn = {0094-8276}, doi = {10.1002/2016GL072345}, pages = {3796 -- 3805}, year = {2017}, abstract = {Glacial periods are recognized to be dustier than interglacials, but the conditions leading to greater dust mobilization are poorly defined. Here we present a new high-resolution dust record based on Th-230-normalized He-4 flux from Ocean Drilling Program site 882 in the Subarctic North Pacific covering the last 170,000years. By analogy with modern relationships, we infer the mechanisms controlling orbital-scale dust storm variability in East Asia. We propose that orbital-scale dust flux variability is the result of an expansion of the dust season into summer, in addition to more intense dust storms during spring and fall. The primary drivers influencing dust flux include summer insolation at subarctic latitudes and variable Siberian alpine glaciation, which together control the cold air reservoir in Siberia. Changes in the extent of the Northern Hemisphere ice sheets may be a secondary control.}, language = {en} } @misc{SchoeneRochSchulzetal.2017, author = {Sch{\"o}ne, Anne-Christin and Roch, Toralf and Schulz, Burkhard and Lendlein, Andreas}, title = {Evaluating polymeric biomaterial-environment interfaces by Langmuir monolayer techniques}, series = {Interface : journal of the Royal Society}, volume = {14}, journal = {Interface : journal of the Royal Society}, publisher = {Royal Society}, address = {London}, issn = {1742-5689}, doi = {10.1098/rsif.2016.1028}, pages = {18}, year = {2017}, abstract = {Polymeric biomaterials are of specific relevance in medical and pharmaceutical applications due to their wide range of tailorable properties and functionalities. The knowledge about interactions of biomaterials with their biological environment is of crucial importance for developing highly sophisticated medical devices. To achieve optimal in vivo performance, a description at the molecular level is required to gain better understanding about the surface of synthetic materials for tailoring their properties. This is still challenging and requires the comprehensive characterization of morphological structures, polymer chain arrangements and degradation behaviour. The review discusses selected aspects for evaluating polymeric biomaterial-environment interfaces by Langmuir monolayer methods as powerful techniques for studying interfacial properties, such as morphological and degradation processes. The combination of spectroscopic, microscopic and scattering methods with the Langmuir techniques adapted to polymers can substantially improve the understanding of their in vivo behaviour.}, language = {en} } @misc{SchusterKrahe2017, author = {Schuster, Isabell and Krah{\´e}, Barbara}, title = {The prevalence of sexual aggression in Turkey: A systematic review}, series = {Aggression and violent behavior : a review journa}, volume = {37}, journal = {Aggression and violent behavior : a review journa}, publisher = {Elsevier}, address = {Oxford}, issn = {1359-1789}, doi = {10.1016/j.avb.2017.05.003}, pages = {102 -- 114}, year = {2017}, abstract = {Although sexual aggression is recognized as a serious problem worldwide, evidence on the prevalence and impact of sexual aggression is based predominantly on studies from Western countries with a Christian or non-religious majority. Little evidence is available from non-Western countries, especially from Muslim societies. The purpose of the present article was to provide a first systematic review of the studies examining the prevalence of sexual aggression in Turkey, including both victimization and perpetration reports from women and men. Additionally, differences in prevalence rates depending on relationship constellations and characteristics of victims and perpetrators were reviewed. By a two-stage literature search, 56 studies were identified for inclusion. All studies examined sexual victimization of women, only four studies included sexual victimization of men. Data on sexual aggression perpetration were extremely limited, with only two studies providing prevalence rates. Prevalence rates of sexual victimization were found to vary greatly, which may be attributed to a lack of methodological and conceptual consistency across studies. Likewise, no consistent picture was revealed for victims' or perpetrators' sociodemographic or situational characteristics associated with differences in prevalence rates. We discuss reasons for the variability in prevalence rates and outline recommendations for future research.}, language = {en} } @misc{SchmidtJochheimKersebaumetal.2017, author = {Schmidt, Martin and Jochheim, Hubert and Kersebaum, Kurt-Christian and Lischeid, Gunnar and Nendel, Claas}, title = {Gradients of microclimate, carbon and nitrogen in transition zones of fragmented landscapes - a review}, series = {Agricultural and forest meteorology}, volume = {232}, journal = {Agricultural and forest meteorology}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0168-1923}, doi = {10.1016/j.agrformet.2016.10.022}, pages = {659 -- 671}, year = {2017}, abstract = {Fragmentation of landscapes creates a transition zone in between natural habitats or different kinds of land use. In forested and agricultural landscapes with transition zones, microclimate and matter cycling are markedly altered. This probably accelerates and is intensified by global warming. However, there is no consensus on defining transition zones and quantifying relevant variables for microclimate and matter cycling across disciplines. This article is an attempt to a) revise definitions and offer a framework for quantitative ecologists, b) review the literature on microclimate and matter cycling in transition zones and c) summarise this information using meta-analysis to better understand bio-geochemical and bio-geophysical processes and their spatial extent in transition zones. We expect altered conditions in soils of transition zones to be 10-20 m with a maximum of 50 m, and 25-50 m for above-ground space with a maximum of 125 m.}, language = {en} } @misc{SchinkoethAntoniewicz2017, author = {Schinkoeth, Michaela and Antoniewicz, Franziska}, title = {Automatic Evaluations and Exercising: Systematic Review and Implications for Future Research}, series = {Frontiers in psychology}, volume = {8}, journal = {Frontiers in psychology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2017.02103}, pages = {19}, year = {2017}, abstract = {The general purpose of this systematic review was to summarize, structure and evaluate the findings on automatic evaluations of exercising. Studies were eligible for inclusion if they reported measuring automatic evaluations of exercising with an implicit measure and assessed some kind of exercise variable. Fourteen nonexperimental and six experimental studies (out of a total N = 1,928) were identified and rated by two independent reviewers. The main study characteristics were extracted and the grade of evidence for each study evaluated. First, results revealed a large heterogeneity in the applied measures to assess automatic evaluations of exercising and the exercise variables. Generally, small to large-sized significant relations between automatic evaluations of exercising and exercise variables were identified in the vast majority of studies. The review offers a systematization of the various examined exercise variables and prompts to differentiate more carefully between actually observed exercise behavior (proximal exercise indicator) and associated physiological or psychological variables (distal exercise indicator). Second, a lack of transparent reported reflections on the differing theoretical basis leading to the use of specific implicit measures was observed. Implicit measures should be applied purposefully, taking into consideration the individual advantages or disadvantages of the measures. Third, 12 studies were rated as providing first-grade evidence (lowest grade of evidence), five represent second-grade and three were rated as third-grade evidence. There is a dramatic lack of experimental studies, which are essential for illustrating the cause-effect relation between automatic evaluations of exercising and exercise and investigating under which conditions automatic evaluations of exercising influence behavior. Conclusions about the necessity of exercise interventions targeted at the alteration of automatic evaluations of exercising should therefore not be drawn too hastily.}, language = {en} } @misc{SadovnichiiPanasyukAmelyushkinetal.2017, author = {Sadovnichii, V. A. and Panasyuk, M. I. and Amelyushkin, A. M. and Bogomolov, V. V. and Benghin, V. V. and Garipov, G. K. and Kalegaev, V. V. and Klimov, P. A. and Khrenov, B. A. and Petrov, V. L. and Sharakin, S. A. and Shirokov, A. V. and Svertilov, S. I. and Zotov, M. Y. and Yashin, I. V. and Gorbovskoy, E. S. and Lipunov, V. M. and Park, I. H. and Lee, J. and Jeong, S. and Kim, M. B. and Jeong, H. M. and Shprits, Yuri Y. and Angelopoulos, V. and Russell, C. T. and Runov, A. and Turner, D. and Strangeway, R. J. and Caron, R. and Biktemerova, S. and Grinyuk, A. and Lavrova, M. and Tkachev, L. and Tkachenko, A. and Martinez, O. and Salazar, H. and Ponce, E.}, title = {"Lomonosov" Satellite-Space Observatory to Study Extreme Phenomena in Space}, series = {Space science reviews}, volume = {212}, journal = {Space science reviews}, publisher = {Springer}, address = {Dordrecht}, issn = {0038-6308}, doi = {10.1007/s11214-017-0425-x}, pages = {1705 -- 1738}, year = {2017}, abstract = {The "Lomonosov" space project is lead by Lomonosov Moscow State University in collaboration with the following key partners: Joint Institute for Nuclear Research, Russia, University of California, Los Angeles (USA), University of Pueblo (Mexico), Sungkyunkwan University (Republic of Korea) and with Russian space industry organi-zations to study some of extreme phenomena in space related to astrophysics, astroparticle physics, space physics, and space biology. The primary goals of this experiment are to study: -Ultra-high energy cosmic rays (UHECR) in the energy range of the Greizen-ZatsepinKuzmin (GZK) cutoff; -Ultraviolet (UV) transient luminous events in the upper atmosphere; -Multi-wavelength study of gamma-ray bursts in visible, UV, gamma, and X-rays; -Energetic trapped and precipitated radiation (electrons and protons) at low-Earth orbit (LEO) in connection with global geomagnetic disturbances; -Multicomponent radiation doses along the orbit of spacecraft under different geomagnetic conditions and testing of space segments of optical observations of space-debris and other space objects; -Instrumental vestibular-sensor conflict of zero-gravity phenomena during space flight. This paper is directed towards the general description of both scientific goals of the project and scientific equipment on board the satellite. The following papers of this issue are devoted to detailed descriptions of scientific instruments.}, language = {en} } @misc{RomaoCoelhoSantosSilvaetal.2017, author = {Romao, Maria Joao and Coelho, Catarina and Santos-Silva, Teresa and Foti, Alessandro and Terao, Mineko and Garattini, Enrico and Leimk{\"u}hler, Silke}, title = {Structural basis for the role of mammalian aldehyde oxidases in the metabolism of drugs and xenobiotics}, series = {Current Opinion in Chemical Biology}, volume = {37}, journal = {Current Opinion in Chemical Biology}, publisher = {Elsevier}, address = {Oxford}, issn = {1367-5931}, doi = {10.1016/j.cbpa.2017.01.005}, pages = {39 -- 47}, year = {2017}, abstract = {Aldehyde oxidases (AOXs) are molybdo-flavoenzymes characterized by broad substrate specificity, oxidizing aromatic/aliphatic aldehydes into the corresponding carboxylic acids and hydroxylating various heteroaromatic rings. Mammals are characterized by a complement of species specific AOX isoenzymes, that varies from one in humans (AOX1) to four in rodents (AOX1, AOX2, AOX3 and AOX4). The physiological function of mammalian AOX isoenzymes is unknown, although human AOX1 is an emerging enzyme in phase-I drug metabolism. Indeed, the number of therapeutic molecules under development which act as AOX substrates is increasing. The recent crystallization and structure determination of human AOX1 as well as mouse AOX3 has brought new insights into the mechanisms underlying substrate/inhibitor binding as well as the catalytic activity of this class of enzymes.}, language = {en} } @misc{NorregaardMetzlerRitteretal.2017, author = {Norregaard, Kamilla and Metzler, Ralf and Ritter, Christine M. and Berg-Sorensen, Kirstine and Oddershede, Lene Broeng}, title = {Manipulation and Motion of Organelles and Single Molecules in Living Cells}, series = {Chemical reviews}, volume = {117}, journal = {Chemical reviews}, number = {5}, publisher = {American Chemical Society}, address = {Washington}, issn = {0009-2665}, doi = {10.1021/acs.chemrev.6b00638}, pages = {4342 -- 4375}, year = {2017}, abstract = {The biomolecule is among the most important building blocks of biological systems, and a full understanding of its function forms the scaffold for describing the mechanisms of higher order structures as organelles and cells. Force is a fundamental regulatory mechanism of biomolecular interactions driving many cellular processes. The forces on a molecular scale are exactly in the range that can be manipulated and probed with single molecule force spectroscopy. The natural environment of a biomolecule is inside a living cell, hence, this is the most relevant environment for probing their function. In vivo studies are, however, challenged by the complexity of the cell. In this review, we start with presenting relevant theoretical tools for analyzing single molecule data obtained in intracellular environments followed by a description of state-of-the art visualization techniques. The most commonly used force spectroscopy techniques, namely optical tweezers, magnetic tweezers, and atomic force microscopy, are described in detail, and their strength and limitations related to in vivo experiments are discussed. Finally, recent exciting discoveries within the field of in vivo manipulation and dynamics of single molecule and organelles are reviewed.}, language = {en} }