@phdthesis{Zhang2019,
  author    = {Zhang, Xiaorong},
  title     = {Electrosynthesis and characterization of molecularly imprinted polymers for peptides and proteins},
  school      = {Universit{\"a}t Potsdam},
  pages     = {116},
  year      = {2019},
  language  = {en}
}
@phdthesis{Zhang2019,
  author    = {Zhang, Shuhao},
  title     = {Synthesis and self-assembly of protein-polymer conjugates for the preparation of biocatalytically active membranes},
  school      = {Universit{\"a}t Potsdam},
  pages     = {VIII, 161},
  year      = {2019},
  abstract  = {This thesis covers the synthesis of conjugates of 2-Deoxy-D-ribose-5-phosphate aldolase (DERA) with suitable polymers and the subsequent immobilization of these conjugates in thin films via two different approaches. 2-Deoxy-D-ribose-5-phosphate aldolase (DERA) is a biocatalyst that is capable of converting acetaldehyde and a second aldehyde as acceptor into enantiomerically pure mono- and diyhydroxyaldehydes, which are important structural motifs in a number of pharmaceutically active compounds. Conjugation and immobilization renders the enzyme applicable for utilization in a continuously run biocatalytic process which avoids the common problem of product inhibition. Within this thesis, conjugates of DERA and poly(N-isopropylacrylamide) (PNIPAm) for immobilization via a self-assembly approach were synthesized and isolated, as well as conjugates with poly(N,N-dimethylacrylamide) (PDMAA) for a simplified and scalable spray-coating approach. For the DERA/PNIPAm-conjugates different synthesis routes were tested, including grafting-from and grafting-to, both being common methods for the conjugation. Furthermore, both lysines and cysteines were addressed for the conjugation in order to find optimum conjugation conditions. It turned out that conjugation via lysine causes severe activity loss as one lysine plays a key role in the catalyzing mechanism. The conjugation via the cysteines by a grafting-to approach using pyridyl disulfide (PDS) end-group functionalized polymers led to high conjugation efficiencies in the presence of polymer solubilizing NaSCN. The resulting conjugates maintained enzymatic activity and also gained high acetaldehyde tolerance which is necessary for their use later on in an industrial relevant process after their immobilization. The resulting DERA/PNIPAm conjugates exhibited enhanced interfacial activity at the air/water interface compared to the single components, which is an important pre-requisite for the immobilization via the self-assembly approach. Conjugates with longer polymer chains formed homogeneous films on silicon wafers and glass slides while the ones with short chains could only form isolated aggregates. On top of that, long chain conjugates showed better activity maintenance upon the immobilization. The crosslinking of conjugates, as well as their fixation on the support materials, are important for the mechanical stability of the films obtained from the self-assembly process. Therefore, in a second step, we introduced the UV-crosslinkable monomer DMMIBA to the PNIPAm polymers to be used for conjugation. The introduction of DMMIBA reduced the lower critical solution temperature (LCST) of the polymer and thus the water solubility at ambient conditions, resulting in lower conjugation efficiencies and in turn slightly poorer acetaldehyde tolerance of the resulting conjugates. Unlike the DERA/PNIPAm, the conjugates from the copolymer P(NIPAM-co-DMMIBA) formed continuous, homogenous films only after the crosslinking step via UV-treatment. For a firm binding of the crosslinked films, a functionalization protocol for the model support material cyclic olefin copolymer (COC) and the final target support, PAN based membranes, was developed that introduces analogue UV-reactive groups to the support surface. The conjugates immobilized on the modified COC films maintained enzymatic activity and showed good mechanical stability after several cycles of activity assessment. Conjugates with longer polymer chains, however, showed a higher degree of crosslinking after the UV-treatment leading to a pronounced loss of activity. A porous PAN membrane onto which the conjugates were immobilized as well, was finally transferred to a dead end filtration membrane module to catalyze the aldol reaction of the industrially relevant mixture of acetaldehyde and hexanal in a continuous mode. Mono aldol product was detectable, but yields were comparably low and the operational stability needs to be further improved Another approach towards immobilization of DERA conjugates that was followed, was to generate the conjugates in situ by simply mixing enzyme and polymer and spray coat the mixture onto the membrane support. Compared to the previous approach, the focus was more put on simplicity and a possible scalability of the immobilization. Conjugates were thus only generated in-situ and not further isolated and characterized. For the conjugation, PDMAA equipped with N-2-thiolactone acrylamide (TlaAm) side chains was used, an amine-reactive comonomer that can react with the lysine residues of DERA, as well as with amino groups introduced to a desired support surface. Furthermore disulfide formation after hydrolysis of the Tla groups causes a crosslinking effect. The synthesized copolymer poly(N,N-Dimethylacrylamide-co-N-2-thiolactone acrylamide) (P(DMAA-co-TlaAm)) thus serves a multiple purpose including protein binding, crosslinking and binding to support materials. The mixture of DERA and polymer could be immobilized on the PAN support by spray-coating under partial maintenance of enzymatic activity. To improve the acetaldehyde tolerance, the polymer in used was further equipped with cysteine reactive PDS end-groups that had been used for the conjugation as described in the first part of the thesis. The generated conjugates indeed showed good acetaldehyde tolerance and were thus used to be coated onto PAN membrane supports. Post treatment with a basic aqueous solution of H2O2 was supposed to further crosslink the spray-coated film hydrolysis and oxidation of the thiolactone groups. However, a washing off of the material was observed. Optimization is thus still necessary.},
  language  = {en}
}
@phdthesis{Zemella2019,
  author    = {Zemella, Anne},
  title     = {Fluoreszenzmarkierung und Modifizierung von komplexen Proteinen in eukaryotischen zellfreien Systemen durch die Etablierung von orthogonalen tRNA/Aminoacyl-tRNA-Synthetase-Paaren},
  doi       = {10.25932/publishup-44236},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-442361},
  school      = {Universit{\"a}t Potsdam},
  pages     = {XI, 141},
  year      = {2019},
  abstract  = {Die funktionelle Charakterisierung von therapeutisch relevanten Proteinen kann bereits durch die Bereitstellung des Zielproteins in ad{\"a}quaten Mengen limitierend sein. Dies trifft besonders auf Membranproteine zu, die aufgrund von zytotoxischen Effekten auf die Produktionszelllinie und der Tendenz Aggregate zu bilden, in niedrigen Ausbeuten an aktivem Protein resultieren k{\"o}nnen. Der lebende Organismus kann durch die Verwendung von translationsaktiven Zelllysaten umgangen werden- die Grundlage der zellfreien Proteinsynthese. Zu Beginn der Arbeit wurde die ATP-abh{\"a}ngige Translation eines Lysates auf der Basis von kultivierten Insektenzellen (Sf21) analysiert. F{\"u}r diesen Zweck wurde ein ATP-bindendes Aptamer eingesetzt, durch welches die Translation der Nanoluziferase reguliert werden konnte. Durch die dargestellte Applizierung von Aptameren, k{\"o}nnten diese zuk{\"u}nftig in zellfreien Systemen f{\"u}r die Visualisierung der Transkription und Translation eingesetzt werden, wodurch zum Beispiel komplexe Prozesse validiert werden k{\"o}nnen. Neben der reinen Proteinherstellung k{\"o}nnen Faktoren wie posttranslationale Modifikationen sowie eine Integration in eine lipidische Membran essentiell f{\"u}r die Funktionalit{\"a}t des Membranproteins sein. Im zweiten Abschnitt konnte, im zellfreien Sf21-System, f{\"u}r den G-Protein-gekoppelten Rezeptor Endothelin B sowohl eine Integration in die endogen vorhandenen Endoplasmatisch Retikulum-basierten Membranstrukturen als auch Glykosylierungen, identifiziert werden. Auf der Grundlage der erfolgreichen Synthese des ET-B-Rezeptors wurden verschiedene Methoden zur Fluoreszenzmarkierung des Adenosin-Rezeptors A2a (Adora2a) angewandt und optimiert. Im dritten Abschnitt wurde der Adora2a mit Hilfe einer vorbeladenen tRNA, welche an eine fluoreszierende Aminos{\"a}ure gekoppelt war, im zellfreien Chinesischen Zwerghamster Ovarien (CHO)-System markiert. Zus{\"a}tzlich konnte durch den Einsatz eines modifizierten tRNA/Aminoacyl-tRNA-Synthetase-Paares eine nicht-kanonische Aminos{\"a}ure an Position eines integrierten Amber-Stopcodon in die Polypeptidkette eingebaut und die funktionelle Gruppe im Anschluss an einen Fluoreszenzfarbstoff gekoppelt werden. Aufgrund des offenen Charakters eignen sich zellfreie Proteinsynthesesysteme besonders f{\"u}r eine Integration von exogenen Komponenten in den Translationsprozess. Mit Hilfe der Fluoreszenzmarkierung wurde eine ligandvermittelte Konformations{\"a}nderung im Adora2a {\"u}ber einen Biolumineszenz-Resonanzenergietransfer detektiert. Durch die Etablierung der Amber-Suppression wurde dar{\"u}ber hinaus das Hormon Erythropoetin pegyliert, wodurch Eigenschaften wie Stabilit{\"a}t und Halbwertszeit des Proteins ver{\"a}ndert wurden. Zu guter Letzt wurde ein neues tRNA/Aminoacyl-tRNA-Synthetase-Paar auf Basis der Methanosarcina mazei Pyrrolysin-Synthetase etabliert, um das Repertoire an nicht-kanonischen Aminos{\"a}uren und den damit verbundenen Kopplungsreaktionen zu erweitern. Zusammenfassend wurden die Potenziale zellfreier Systeme in Bezug auf der Herstellung von komplexen Membranproteinen und der Charakterisierung dieser durch die Einbringung einer positionsspezifischen Fluoreszenzmarkierung verdeutlicht, wodurch neue M{\"o}glichkeiten f{\"u}r die Analyse und Funktionalisierung von komplexen Proteinen geschaffen wurden.},
  language  = {de}
}
@phdthesis{Zapata2019,
  author    = {Zapata, Sebastian Henao},
  title     = {Paleozoic to Pliocene evolution of the Andean retroarc between 26 and 28°S: interactions between tectonics, climate, and upper plate architecture},
  doi       = {10.25932/publishup-43903},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-439036},
  school      = {Universit{\"a}t Potsdam},
  pages     = {139},
  year      = {2019},
  abstract  = {Interactions and feedbacks between tectonics, climate, and upper plate architecture control basin geometry, relief, and depositional systems. The Andes is part of a longlived continental margin characterized by multiple tectonic cycles which have strongly modified the Andean upper plate architecture. In the Andean retroarc, spatiotemporal variations in the structure of the upper plate and tectonic regimes have resulted in marked along-strike variations in basin geometry, stratigraphy, deformational style, and mountain belt morphology. These along-strike variations include high-elevation plateaus (Altiplano and Puna) associated with a thin-skin fold-and-thrust-belt and thick-skin deformation in broken foreland basins such as the Santa Barbara system and the Sierras Pampeanas. At the confluence of the Puna Plateau, the Santa Barbara system and the Sierras Pampeanas, major along-strike changes in upper plate architecture, mountain belt morphology, basement exhumation, and deformation style can be recognized. I have used a source to sink approach to unravel the spatiotemporal tectonic evolution of the Andean retroarc between 26 and 28°S. I obtained a large low-temperature thermochronology data set from basement units which includes apatite fission track, apatite U-Th-Sm/He, and zircon U-Th/He (ZHe) cooling ages. Stratigraphic descriptions of Miocene units were temporally constrained by U-Pb LA-ICP-MS zircon ages from interbedded pyroclastic material. Modeled ZHe ages suggest that the basement of the study area was exhumed during the Famatinian orogeny (550-450 Ma), followed by a period of relative tectonic quiescence during the Paleozoic and the Triassic. The basement experienced horst exhumation during the Cretaceous development of the Salta rift. After initial exhumation, deposition of thick Cretaceous syn-rift strata caused reheating of several basement blocks within the Santa Barbara system. During the Eocene-Oligocene, the Andean compressional setting was responsible for the exhumation of several disconnected basement blocks. These exhumed blocks were separated by areas of low relief, in which humid climate and low erosion rates facilitated the development of etchplains on the crystalline basement. The exhumed basement blocks formed an Eocene to Oligocene broken foreland basin in the back-bulge depozone of the Andean foreland. During the Early Miocene, foreland basin strata filled up the preexisting Paleogene topography. The basement blocks in lower relief positions were reheated; associated geothermal gradients were higher than 25°C/km. Miocene volcanism was responsible for lateral variations on the amount of reheating along the Campo-Arenal basin. Around 12 Ma, a new deformational phase modified the drainage network and fragmented the lacustrine system. As deformation and rock uplift continued, the easily eroded sedimentary cover was efficiently removed and reworked by an ephemeral fluvial system, preventing the development of significant relief. After ~6 Ma, the low erodibility of the basement blocks which began to be exposed caused relief increase, leading to the development of stable fluvial systems. Progressive relief development modified atmospheric circulation, creating a rainfall gradient. After 3 Ma, orographic rainfall and high relief lead to the development of proximal fluvial-gravitational depositional systems in the surrounding basins.},
  language  = {en}
}
@phdthesis{Yishai2019,
  author    = {Yishai, Oren},
  title     = {Engineering the reductive glycine pathway in Escherichia coli},
  school      = {Universit{\"a}t Potsdam},
  pages     = {86},
  year      = {2019},
  language  = {en}
}
@phdthesis{Yan2019,
  author    = {Yan, Runyu},
  title     = {Nitrogen-doped and porous carbons towards new energy storage mechanisms for supercapacitors with high energy density},
  doi       = {10.25932/publishup-43141},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-431413},
  school      = {Universit{\"a}t Potsdam},
  pages     = {152},
  year      = {2019},
  abstract  = {Supercapacitors are electrochemical energy storage devices with rapid charge/discharge rate and long cycle life. Their biggest challenge is the inferior energy density compared to other electrochemical energy storage devices such as batteries. Being the most widely spread type of supercapacitors, electrochemical double-layer capacitors (EDLCs) store energy by electrosorption of electrolyte ions on the surface of charged electrodes. As a more recent development, Na-ion capacitors (NICs) are expected to be a more promising tactic to tackle the inferior energy density due to their higher-capacity electrodes and larger operating voltage. The charges are simultaneously stored by ion adsorption on the capacitive-type cathode surface and via faradic process in the battery-type anode, respectively. Porous carbon electrodes are of great importance in these devices, but the paramount problems are the facile synthetic routes for high-performance carbons and the lack of fundamental understanding of the energy storage mechanisms. Therefore, the aim of the present dissertation is to develop novel synthetic methods for (nitrogen-doped) porous carbon materials with superior performance, and to reveal a deeper understanding energy storage mechanisms of EDLCs and NICs. The first part introduces a novel synthetic method towards hierarchical ordered meso-microporous carbon electrode materials for EDLCs. The large amount of micropores and highly ordered mesopores endow abundant sites for charge storage and efficient electrolyte transport, respectively, giving rise to superior EDLC performance in different electrolytes. More importantly, the controversial energy storage mechanism of EDLCs employing ionic liquid (IL) electrolytes is investigated by employing a series of porous model carbons as electrodes. The results not only allow to conclude on the relations between the porosity and ion transport dynamics, but also deliver deeper insights into the energy storage mechanism of IL-based EDLCs which is different from the one usually dominating in solvent-based electrolytes leading to compression double-layers. The other part focuses on anodes of NICs, where novel synthesis of nitrogen-rich porous carbon electrodes and their sodium storage mechanism are investigated. Free-standing fibrous nitrogen-doped carbon materials are synthesized by electrospinning using the nitrogen-rich monomer (hexaazatriphenylene-hexacarbonitrile, C18N12) as the precursor followed by condensation at high temperature. These fibers provide superior capacity and desirable charge/discharge rate for sodium storage. This work also allows insights into the sodium storage mechanism in nitrogen-doped carbons. Based on this mechanism, further optimization is done by designing a composite material composed of nitrogen-rich carbon nanoparticles embedded in conductive carbon matrix for a better charge/discharge rate. The energy density of the assembled NICs significantly prevails that of common EDLCs while maintaining the high power density and long cycle life.},
  language  = {en}
}
@phdthesis{Wozny2019,
  author    = {Wozny, Florian},
  title     = {Three empirical essays in health economics},
  doi       = {10.25932/publishup-46991},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-469910},
  school      = {Universit{\"a}t Potsdam},
  pages     = {200},
  year      = {2019},
  abstract  = {Modern health care systems are characterized by pronounced prevention and cost-optimized treatments. This dissertation offers novel empirical evidence on how useful such measures can be. The first chapter analyzes how radiation, a main pollutant in health care, can negatively affect cognitive health. The second chapter focuses on the effect of Low Emission Zones on public heath, as air quality is the major external source of health problems. Both chapters point out potentials for preventive measures. Finally, chapter three studies how changes in treatment prices affect the reallocation of hospital resources. In the following, I briefly summarize each chapter and discuss implications for health care systems as well as other policy areas. Based on the National Educational Panel Study that is linked to data on radiation, chapter one shows that radiation can have negative long-term effects on cognitive skills, even at subclinical doses. Exploiting arguably exogenous variation in soil contamination in Germany due to the Chernobyl disaster in 1986, the findings show that people exposed to higher radiation perform significantly worse in cognitive tests 25 years later. Identification is ensured by abnormal rainfall within a critical period of ten days. The results show that the effect is stronger among older cohorts than younger cohorts, which is consistent with radiation accelerating cognitive decline as people get older. On average, a one-standarddeviation increase in the initial level of CS137 (around 30 chest x-rays) is associated with a decrease in the cognitive skills by 4.1 percent of a standard deviation (around 0.05 school years). Chapter one shows that sub-clinical levels of radiation can have negative consequences even after early childhood. This is of particular importance because most of the literature focuses on exposure very early in life, often during pregnancy. However, population exposed after birth is over 100 times larger. These results point to substantial external human capital costs of radiation which can be reduced by choices of medical procedures. There is a large potential for reductions because about one-third of all CT scans are assumed to be not medically justified (Brenner and Hall, 2007). If people receive unnecessary CT scans because of economic incentives, this chapter points to additional external costs of health care policies. Furthermore, the results can inform the cost-benefit trade-off for medically indicated procedures. Chapter two provides evidence about the effectiveness of Low Emission Zones. Low Emission Zones are typically justified by improvements in population health. However, there is little evidence about the potential health benefits from policy interventions aiming at improving air quality in inner-cities. The chapter ask how the coverage of Low Emission Zones air pollution and hospitalization, by exploiting variation in the roll out of Low Emission Zones in Germany. It combines information on the geographic coverage of Low Emission Zones with rich panel data on the universe of German hospitals over the period from 2006 to 2016 with precise information on hospital locations and the annual frequency of detailed diagnoses. In order to establish that our estimates of Low Emission Zones' health impacts can indeed be attributed to improvements in local air quality, we use data from Germany's official air pollution monitoring system and assign monitor locations to Low Emission Zones and test whether measures of air pollution are affected by the coverage of a Low Emission Zone. Results in chapter two confirm former results showing that the introduction of Low Emission Zones improved air quality significantly by reducing NO2 and PM10 concentrations. Furthermore, the chapter shows that hospitals which catchment areas are covered by a Low Emission Zone, diagnose significantly less air pollution related diseases, in particular by reducing the incidents of chronic diseases of the circulatory and the respiratory system. The effect is stronger before 2012, which is consistent with a general improvement in the vehicle fleet's emission standards. Depending on the disease, a one-standard-deviation increase in the coverage of a hospitals catchment area covered by a Low Emission Zone reduces the yearly number of diagnoses up to 5 percent. These findings have strong implications for policy makers. In 2015, overall costs for health care in Germany were around 340 billion euros, of which 46 billion euros for diseases of the circulatory system, making it the most expensive type of disease caused by 2.9 million cases (Statistisches Bundesamt, 2017b). Hence, reductions in the incidence of diseases of the circulatory system may directly reduce society's health care costs. Whereas chapter one and two study the demand-side in health care markets and thus preventive potential, chapter three analyzes the supply-side. By exploiting the same hospital panel data set as in chapter two, chapter three studies the effect of treatment price shocks on the reallocation of hospital resources in Germany. Starting in 2005, the implementation of the German-DRG-System led to general idiosyncratic treatment price shocks for individual hospitals. Thus far there is little evidence of the impact of general price shocks on the reallocation of hospital resources. Additionally, I add to the exiting literature by showing that price shocks can have persistent effects on hospital resources even when these shocks vanish. However, simple OLS regressions would underestimate the true effect, due to endogenous treatment price shocks. I implement a novel instrument variable strategy that exploits the exogenous variation in the number of days of snow in hospital catchment areas. A peculiarity of the reform allowed variation in days of snow to have a persistent impact on treatment prices. I find that treatment price increases lead to increases in input factors such as nursing staff, physicians and the range of treatments offered but to decreases in the treatment volume. This indicates supplier-induced demand. Furthermore, the probability of hospital mergers and privatization decreases. Structural differences in pre-treatment characteristics between hospitals enhance these effects. For instance, private and larger hospitals are more affected. IV estimates reveal that OLS results are biased towards zero in almost all dimensions because structural hospital differences are correlated with the reallocation of hospital resources. These results are important for several reasons. The G-DRG-Reform led to a persistent polarization of hospital resources, as some hospitals were exposed to treatment price increases, while others experienced reductions. If hospitals increase the treatment volume as a response to price reductions by offering unnecessary therapies, it has a negative impact on population wellbeing and public spending. However, results show a decrease in the range of treatments if prices decrease. Hospitals might specialize more, thus attracting more patients. From a policy perspective it is important to evaluate if such changes in the range of treatments jeopardize an adequate nationwide provision of treatments. Furthermore, the results show a decrease in the number of nurses and physicians if prices decrease. This could partly explain the nursing crisis in German hospitals. However, since hospitals specialize more they might be able to realize efficiency gains which justify reductions in input factors without loses in quality. Further research is necessary to provide evidence for the impact of the G-DRG-Reform on health care quality. Another important aspect are changes in the organizational structure. Many public hospitals have been privatized or merged. The findings show that this is at least partly driven by the G-DRG-Reform. This can again lead to a lack in services offered in some regions if merged hospitals specialize more or if hospitals are taken over by ecclesiastical organizations which do not provide all treatments due to moral conviction. Overall, this dissertation reveals large potential for preventive health care measures and helps to explain reallocation processes in the hospital sector if treatment prices change. Furthermore, its findings have potentially relevant implications for other areas of public policy. Chapter one identifies an effect of low dose radiation on cognitive health. As mankind is searching for new energy sources, nuclear power is becoming popular again. However, results of chapter one point to substantial costs of nuclear energy which have not been accounted yet. Chapter two finds strong evidence that air quality improvements by Low Emission Zones translate into health improvements, even at relatively low levels of air pollution. These findings may, for instance, be of relevance to design further policies targeted at air pollution such as diesel bans. As pointed out in chapter three, the implementation of DRG-Systems may have unintended side-effects on the reallocation of hospital resources. This may also apply to other providers in the health care sector such as resident doctors.},
  language  = {en}
}
@phdthesis{Wozniak2019,
  author    = {Wozniak, Natalia Joanna},
  title     = {Convergent evolution of the selfing syndrome in the genus Capsella},
  school      = {Universit{\"a}t Potsdam},
  pages     = {229},
  year      = {2019},
  language  = {en}
}
@phdthesis{Wolf2019,
  author    = {Wolf, Mathias Johannes},
  title     = {The role of partial melting on trace element and isotope systematics of granitic melts},
  doi       = {10.25932/publishup-42370},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-423702},
  school      = {Universit{\"a}t Potsdam},
  pages     = {iv, 129},
  year      = {2019},
  abstract  = {Partial melting is a first order process for the chemical differentiation of the crust (Vielzeuf et al., 1990). Redistribution of chemical elements during melt generation crucially influences the composition of the lower and upper crust and provides a mechanism to concentrate and transport chemical elements that may also be of economic interest. Understanding of the diverse processes and their controlling factors is therefore not only of scientific interest but also of high economic importance to cover the demand for rare metals. The redistribution of major and trace elements during partial melting represents a central step for the understanding how granite-bound mineralization develops (Hedenquist and Lowenstern, 1994). The partial melt generation and mobilization of ore elements (e.g. Sn, W, Nb, Ta) into the melt depends on the composition of the sedimentary source and melting conditions. Distinct source rocks have different compositions reflecting their deposition and alteration histories. This specific chemical "memory" results in different mineral assemblages and melting reactions for different protolith compositions during prograde metamorphism (Brown and Fyfe, 1970; Thompson, 1982; Vielzeuf and Holloway, 1988). These factors do not only exert an important influence on the distribution of chemical elements during melt generation, they also influence the volume of melt that is produced, extraction of the melt from its source, and its ascent through the crust (Le Breton and Thompson, 1988). On a larger scale, protolith distribution and chemical alteration (weathering), prograde metamorphism with partial melting, melt extraction, and granite emplacement are ultimately depending on a (plate-)tectonic control (Romer and Kroner, 2016). Comprehension of the individual stages and their interaction is crucial in understanding how granite-related mineralization forms, thereby allowing estimation of the mineralization potential of certain areas. Partial melting also influences the isotope systematics of melt and restite. Radiogenic and stable isotopes of magmatic rocks are commonly used to trace back the source of intrusions or to quantify mixing of magmas from different sources with distinct isotopic signatures (DePaolo and Wasserburg, 1979; Lesher, 1990; Chappell, 1996). These applications are based on the fundamental requirement that the isotopic signature in the melt reflects that of the bulk source from which it is derived. Different minerals in a protolith may have isotopic compositions of radiogenic isotopes that deviate from their whole rock signature (Ayres and Harris, 1997; Knesel and Davidson, 2002). In particular, old minerals with a distinct parent-to-daughter (P/D) ratio are expected to have a specific radiogenic isotope signature. As the partial melting reaction only involves selective phases in a protolith, the isotopic signature of the melt reflects that of the minerals involved in the melting reaction and, therefore, should be different from the bulk source signature. Similar considerations hold true for stable isotopes.},
  language  = {en}
}
@phdthesis{Willig2019,
  author    = {Willig, Lisa},
  title     = {Ultrafast magneto-optical studies of remagnetisation dynamics in transition metals},
  doi       = {10.25932/publishup-44194},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-441942},
  school      = {Universit{\"a}t Potsdam},
  pages     = {XIV, 113, XVII},
  year      = {2019},
  abstract  = {Ultrafast magnetisation dynamics have been investigated intensely for two decades. The recovery process after demagnetisation, however, was rarely studied experimentally and discussed in detail. The focus of this work lies on the investigation of the magnetisation on long timescales after laser excitation. It combines two ultrafast time resolved methods to study the relaxation of the magnetic and lattice system after excitation with a high fluence ultrashort laser pulse. The magnetic system is investigated by time resolved measurements of the magneto-optical Kerr effect. The experimental setup has been implemented in the scope of this work. The lattice dynamics were obtained with ultrafast X-ray diffraction. The combination of both techniques leads to a better understanding of the mechanisms involved in magnetisation recovery from a non-equilibrium condition. Three different groups of samples are investigated in this work: Thin Nickel layers capped with nonmagnetic materials, a continuous sample of the ordered L10 phase of Iron Platinum and a sample consisting of Iron Platinum nanoparticles embedded in a carbon matrix. The study of the remagnetisation reveals a general trend for all of the samples: The remagnetisation process can be described by two time dependences. A first exponential recovery that slows down with an increasing amount of energy absorbed in the system until an approximately linear time dependence is observed. This is followed by a second exponential recovery. In case of low fluence excitation, the first recovery is faster than the second. With increasing fluence the first recovery is slowed down and can be described as a linear function. If the pump-induced temperature increase in the sample is sufficiently high, a phase transition to a paramagnetic state is observed. In the remagnetisation process, the transition into the ferromagnetic state is characterised by a distinct transition between the linear and exponential recovery. From the combination of the transient lattice temperature Tp(t) obtained from ultrafast X-ray measurements and magnetisation M(t) gained from magneto-optical measurements we construct the transient magnetisation versus temperature relations M(Tp). If the lattice temperature remains below the Curie temperature the remagnetisation curve M(Tp) is linear and stays below the M(T) curve in equilibrium in the continuous transition metal layers. When the sample is heated above phase transition, the remagnetisation converges towards the static temperature dependence. For the granular Iron Platinum sample the M(Tp) curves for different fluences coincide, i.e. the remagnetisation follows a similar path irrespective of the initial laser-induced temperature jump.},
  language  = {en}
}
@phdthesis{Westendorf2019,
  author    = {Westendorf, Martin},
  title     = {Der Betrieb gewerblicher Art},
  series = {Schriften zum Steuerrecht ; 147},
  journal   = {Schriften zum Steuerrecht ; 147},
  publisher = {Duncker \& Humblot},
  address   = {Berlin},
  isbn      = {978-3-428-15783-9},
  pages     = {362},
  year      = {2019},
  abstract  = {Die Arbeit untersucht die Grundlagen der Besteuerung der {\"o}ffentlichen Hand, hier insbesondere die geschichtliche Entwicklung des Betriebs gewerblicher Art und die seit 2009 geltende Querverbundsystematik. Es wird die Entwicklung der einzelnen Tatbest{\"a}nde bis hin zur tatbestandsm{\"a}ßigen Zusammenfassung einzelner Betriebe gewerblicher Art untersucht. Dabei stehen immer wieder die Wettbewerbssystematik und der steuerliche Gleichbehandlungsgrundsatz im Diskussionsmittelpunkt. Nachstehend schließt sich ein Vergleich zwischen dem horizontalen und vertikalen Querverbund an, der die grundlegenden Rechtsfolgen und die dauerdefizit{\"a}ren Bet{\"a}tigungen umfasst. Das Ergebnis zeigt auf, dass die {\"o}ffentliche Hand mit ihrem wahlweisen horizontalen Querverbund und der fehlenden Gewinnerzielungsabsicht erhebliche Vorteile gegen{\"u}ber privatrechtlich gef{\"u}hrten Unternehmensformen genießt und somit erhebliches Steuersparpotential generiert.},
  language  = {de}
}
@phdthesis{Wernert2019,
  author    = {Wernert, Yann},
  title     = {Internationale Kooperation in der Rohstoffpolitik},
  publisher = {Springer VS},
  address   = {Wiesbaden},
  isbn      = {978-3-658-28517-3},
  doi       = {10.1007/978-3-658-28518-0},
  school      = {Universit{\"a}t Potsdam},
  pages     = {521},
  year      = {2019},
  abstract  = {Deutschland und Frankreich ben{\"o}tigen stetige Metallimporte, um ihr Wirtschaftsmodell aufrechtzuerhalten. Internationale Kooperation ist unerl{\"a}sslich, damit diese Importe zuverl{\"a}ssig und nachhaltig verlaufen. Doch welche Potenziale bieten sich in diesem Bereich, welche Grenzen sind dabei zu erkennen? Dieser Frage geht Yann Wernert durch einen Fallstudienvergleich mit prozessanalytischen Methoden und auf der theoretischen Grundlage des neoliberalen Institutionalismus nach. Er zeigt, dass beide L{\"a}nder ihre Bem{\"u}hungen als reaktive Mittelm{\"a}chte gestalten. Sie wollen durch staatliche Rohstoffstrategien wirtschaftliche, strategische und Nachhaltigkeitsziele erreichen. W{\"a}hrend die Analyse durchaus Kooperationspotenziale ausmacht, fallen diese je nach L{\"a}ndergruppe und Politikbereich sehr unterschiedlich aus.},
  language  = {de}
}
@phdthesis{Weber2019,
  author    = {Weber, Marie-Christin},
  title     = {Performance Enhancing Strategies in Different Negotiation Phases},
  publisher = {Kovac},
  address   = {Hamburg},
  isbn      = {978-3-339-10946-0},
  school      = {Universit{\"a}t Potsdam},
  pages     = {78},
  year      = {2019},
  abstract  = {The present dissertation investigates profit-maximizing behavior in different phases of the negotiation process. Over the last decades, research dealt in detail with behavior of negotiation actors with the aim of identifying performance enhancing factors. The majority of those studies focused on behavior within the main negotiation phase. This work, however, considers phases which are, so far, underrepresented in research but show an impact on the negotiation process and outcome. Those phases are the pre-negotiation, the first offer, and the main negotiation phase which is further divided by breaks into several rounds. Within these phases, traits of behavior are analyzed that can be used strategically in order to impact the negotiation outcome. The dissertation contains three papers, each one dealing with a specific strategy within one phase. The first paper investigates communication behavior in the pre-negotiation phase. Content analysis of a negotiation experiment shows that the employment of positive communication elements such as the generation of enthusiasm for an upcoming project results in an increase of agreements on entering a negotiation and also leads to a higher willingness to make concessions. The second paper explores the impact of a semantic first anchor, which does not contain a specific number but only gives a numerical direction, on the opponent's concession behavior and the final outcome. By means of two scenario-based questionnaires and a negotiation experiment it is demonstrated that semantic offers reveal an anchoring effect and lead to better negotiation outcomes. The third paper deals with the introduction of breaks and their effect on the following negotiation process. Therefore, content and outcome of another negotiation experiment are investigated. The analysis shows that breaks evoke a dominant impression but can negatively impact the atmosphere and thereby also the outcome. Finally, the gathered insights are brought together and discussed. The dissertation closes with implications for practice, limitations of the work, and ideas for future research.},
  language  = {en}
}
@phdthesis{Wardecki2019,
  author    = {Wardecki, Bartek},
  title     = {Berlin, Leipziger Straße 3-4},
  publisher = {be.bra wissenschaft Verlag},
  address   = {Berlin},
  isbn      = {978-3-95410-235-8},
  school      = {Universit{\"a}t Potsdam},
  pages     = {382},
  year      = {2019},
  abstract  = {In der Leipziger Straße 3-4 in Berlin, in der seit Herbst 2000 der Deutsche Bundesrat residiert, waren seit jeher bedeutende Institutionen angesiedelt. 1904 errichtet f{\"u}r das Preußische Herrenhaus, wurde das Geb{\"a}ude nach dem Ersten Weltkrieg von den Arbeiter- und Soldatenr{\"a}ten genutzt. In der Weimarer Republik teilten sich der Preußische Staatsrat und das Preußische Wohlfahrtsministerium das Haus. Im Nationalsozialismus arbeiteten hier u. a. das Reichskirchenministerium und die Reichsstelle f{\"u}r Raumordnung. Bartek Wardecki bietet eine vollst{\"a}ndige Darstellung der Geschichte dieser ber{\"u}hmten Adresse sowie eine {\"U}bersicht {\"u}ber ann{\"a}hernd 1000 Veranstaltungen, die hier ausgerichtet wurden.},
  language  = {de}
}
@phdthesis{Wang2019,
  author    = {Wang, Xuepu},
  title     = {Polydimethylsiloxane wrinkles for surface patterns and assembly of metallic nanoparticles},
  school      = {Universit{\"a}t Potsdam},
  pages     = {131},
  year      = {2019},
  language  = {en}
}
@phdthesis{Walczak2019,
  author    = {Walczak, Ralf},
  title     = {Molecular design of nitrogen-doped nanoporous noble carbon materials for gas adsorption},
  doi       = {10.25932/publishup-43524},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-435241},
  school      = {Universit{\"a}t Potsdam},
  pages     = {II, 155},
  year      = {2019},
  abstract  = {In den modernen Gesellschaften f{\"u}hrt ein stetig steigender Energiebedarf zu dem zunehmenden Verbrauch fossiler Brennstoffe wie Kohle, {\"O}l, und Gas. Die Verbrennung dieser kohlenstoffbasierten Brennstoffe f{\"u}hrt unweigerlich zur Freisetzung von Treibhausgasen, vor allem von CO2. Die CO2 Aufnahme unmittelbar bei den Verbrennungsanlagen oder direkt aus der Luft, zusammen mit Regulierung von CO2 produzierenden Energiesektoren (z.B. K{\"u}hlanlagen), k{\"o}nnen den CO2 Ausstoß reduzieren. Allerdings f{\"u}hren insbesondere bei der CO2 Aufnahme die geringen CO2 Konzentrationen und die Aufnahme konkurrierender Gase zu niedrigen CO2 Kapazit{\"a}ten und Selektivit{\"a}ten. Das Zusammenspiel der Gastmolek{\"u}le mit por{\"o}sen Materialien ist dabei essentiell. Por{\"o}se Kohlenstoffmaterialien besitzen attraktive Eigenschaften, unter anderem elektrische Leitf{\"a}higkeit, einstellbare Porosit{\"a}t, als auch chemische und thermische Stabilit{\"a}t. Allerdings f{\"u}hrt die zu geringe Polarisierbarkeit dieser Materialien zu einer geringen Affinit{\"a}t zu polaren Molek{\"u}len (z.B. CO2, H2O, oder NH3). Diese Affinit{\"a}t kann durch den Einbau von Stickstoff erh{\"o}ht werden. Solche Materialien sind oft „edler" als reine Kohlenstoffe, dies bedeutet, dass sie eher oxidierend wirken, als selbst oxidiert zu werden. Die Problematik besteht darin, einen hohen und gleichm{\"a}ßig verteilten Stickstoffgehalt in das Kohlenstoffger{\"u}st einzubauen. Die Zielsetzung dieser Dissertation ist die Erforschung neuer Synthesewege f{\"u}r stickstoffdotierte edle Kohlenstoffmaterialien und die Entwicklung eines grundlegenden Verst{\"a}ndnisses f{\"u}r deren Anwendung in Gasadsorption und elektrochemischer Energiespeicherung. Es wurde eine templatfreie Synthese f{\"u}r stickstoffreiche, edle, und mikropor{\"o}se Kohlenstoffmaterialien durch direkte Kondensation eines stickstoffreichen organischen Molek{\"u}ls als Vorl{\"a}ufer erarbeitet. Dadurch konnten Materialien mit hohen Adsorptionskapazit{\"a}ten f{\"u}r H2O und CO2 bei niedrigen Konzentrationen und moderate CO2/N2 Selektivit{\"a}ten erzielt werden. Um die CO2/N2 Selektivit{\"a}ten zu verbessern, wurden mittels der Einstellung des Kondensationsgrades die molekulare Struktur und Porosit{\"a}t der Kohlenstoffmaterialien kontrolliert. Diese Materialien besitzen die Eigenschaften eines molekularen Siebs f{\"u}r CO2 {\"u}ber N2, das zu herausragenden CO2/N2 Selektivit{\"a}ten f{\"u}hrt. Der ultrahydrophile Charakter der Porenoberfl{\"a}chen und die kleinen Mikroporen dieser Kohlenstoffmaterialien erm{\"o}glichen grundlegende Untersuchungen f{\"u}r die Wechselwirkungen mit Molek{\"u}len die polarer sind als CO2, n{\"a}mlich H2O und NH3. Eine weitere Reihe stickstoffdotierter Kohlenstoffmaterialien wurde durch Kondensation eines konjugierten mikropor{\"o}sen Polymers synthetisiert und deren strukturelle Besonderheiten als Anodenmaterial f{\"u}r die Natriumionen Batterie untersucht. Diese Dissertation leistet einen Beitrag zur Erforschung stickstoffdotierter Kohlenstoffmaterialien und deren Wechselwirkungen mit verschiedenen Gastmolek{\"u}len.},
  language  = {en}
}
@phdthesis{Wagle2019,
  author    = {Wagle, Swapnil},
  title     = {Multi scale modeling of SNARE-mimetic peptides for their applications in membrane fusion},
  pages     = {105},
  year      = {2019},
  language  = {en}
}
@phdthesis{Vranic2019,
  author    = {Vranic, Marija},
  title     = {3D Structure of the biomarker hepcidin-25 in its native state},
  doi       = {10.25932/publishup-45929},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-459295},
  school      = {Universit{\"a}t Potsdam},
  pages     = {xii, 135},
  year      = {2019},
  abstract  = {Hepcidin-25 (Hep-25) plays a crucial role in the control of iron homeostasis. Since the dysfunction of the hepcidin pathway leads to multiple diseases as a result of iron imbalance, hepcidin represents a potential target for the diagnosis and treatment of disorders of iron metabolism. Despite intense research in the last decade targeted at developing a selective immunoassay for iron disorder diagnosis and treatment and better understanding the ferroportin-hepcidin interaction, questions remain. The key to resolving these underlying questions is acquiring exact knowledge of the 3D structure of native Hep-25. Since it was determined that the N-terminus, which is responsible for the bioactivity of Hep-25, contains a small Cu(II)-binding site known as the ATCUN motif, it was assumed that the Hep-25-Cu(II) complex is the native, bioactive form of the hepcidin. This structure has thus far not been elucidated in detail. Owing to the lack of structural information on metal-bound Hep-25, little is known about its possible biological role in iron metabolism. Therefore, this work is focused on structurally characterizing the metal-bound Hep-25 by NMR spectroscopy and molecular dynamics simulations. For the present work, a protocol was developed to prepare and purify properly folded Hep-25 in high quantities. In order to overcome the low solubility of Hep-25 at neutral pH, we introduced the C-terminal DEDEDE solubility tag. The metal binding was investigated through a series of NMR spectroscopic experiments to identify the most affected amino acids that mediate metal coordination. Based on the obtained NMR data, a structural calculation was performed in order to generate a model structure of the Hep-25-Ni(II) complex. The DEDEDE tag was excluded from the structural calculation due to a lack of NMR restraints. The dynamic nature and fast exchange of some of the amide protons with solvent reduced the overall number of NMR restraints needed for a high-quality structure. The NMR data revealed that the 20 Cterminal Hep-25 amino acids experienced no significant conformational changes, compared to published results, as a result of a pH change from pH 3 to pH 7 and metal binding. A 3D model of the Hep-25-Ni(II) complex was constructed from NMR data recorded for the hexapeptideNi(II) complex and Hep-25-DEDEDE-Ni(II) complex in combination with the fixed conformation of 19 C-terminal amino acids. The NMR data of the Hep-25-DEDEDE-Ni(II) complex indicates that the ATCUN motif moves independently from the rest of the structure. The 3D model structure of the metal-bound Hep-25 allows for future works to elucidate hepcidin's interaction with its receptor ferroportin and should serve as a starting point for the development of antibodies with improved selectivity.},
  language  = {en}
}
@phdthesis{Voss2019,
  author    = {Voß, Amira},
  title     = {F{\"u}r eine Reformierung des irakischen internationalen Privatrechts},
  doi       = {10.25932/publishup-43019},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-430190},
  school      = {Universit{\"a}t Potsdam},
  pages     = {XIII; 272},
  year      = {2019},
  abstract  = {Seit 2003 hat sich das politische Bild des Irak stark ver{\"a}ndert. Dadurch begann der Prozess der Neugestaltung der irakischen Rechtsordnung. Die irakische Verfassung von 2005 legt erstmalig in der Geschichte des Irak den Islam und die Demokratie als zwei nebeneinander zu beachtende Grundprinzipien bei der Gesetzgebung fest. Trotz dieser signifikanten Ver{\"a}nderung im irakischen Rechtssystem und erheblicher Entwicklungen im internationalen Privat- und Zivilverfahrensrecht (IPR/IZVR) im internationalen Vergleich gilt die haupts{\"a}chlich im irakischen Zivilgesetzbuch (ZGB) von 1951 enthaltene gesetzliche Regelung des IPR/IZVR im Irak weiterhin. Deshalb entstand diese Arbeit f{\"u}r eine Reformierung des irakischen IPR/IZVR. Die Arbeit gilt als erste umfassende wissenschaftliche Untersuchung, die sich mit dem jetzigen Inhalt und der zuk{\"u}nftigen Reformierung des irakischen internationalen Privatrecht- und Zivilverfahrensrechts (IPR/IZVR) besch{\"a}ftigt. Die Verfasserin vermittelt einen Gesamt{\"u}berblick {\"u}ber das jetzt geltende irakische internationale Privat- und Zivilverfahrensrecht mit gelegentlicher punktueller und stichwortartiger Heranziehung des deutschen, islamischen, t{\"u}rkischen und tunesischen Rechts, zeigt dessen Schwachstellen auf und unterbreitet entsprechende Reformvorschl{\"a}ge. Wegen der besonderen Bedeutung des internationalen Vertragsrechts f{\"u}r die Wirtschaft im Irak und auch zum Teil f{\"u}r Deutschland gibt die Verfasserin einen genaueren {\"U}berblick {\"u}ber das irakische internationale Vertragsrecht und bekr{\"a}ftigt gleichzeitig dessen Reformbed{\"u}rftigkeit. Die Darstellung der wichtigen Entwicklungen im deutsch-europ{\"a}ischen, im traditionellen islamischen Recht und im t{\"u}rkischen und tunesischen internationalen Privat- und Zivilverfahrensrecht im zweiten Kapitel dienen als Grundlage, auf die bei der Reformierung des irakischen IPR/ IZVR zur{\"u}ck gegriffen werden kann. Da die Kenntnisse des islamischen Rechts nicht zwingend zum Rechtsstudium geh{\"o}ren, wird das islamische Recht dazu in Bezug auf seine Entstehung und die Rechtsquellen dargestellt. Am Ende der Arbeit wird ein Entwurf eines f{\"o}deralen Gesetzes zum internationalen Privatrecht im Irak katalogisiert, der sich im Rahmen der irakischen Verfassung gleichzeitig mit dem Islam und der Demokratie vereinbaren l{\"a}sst.},
  language  = {de}
}
@phdthesis{Vorholt2019,
  author    = {Vorholt, Dominik},
  title     = {Konkurrenzausschluss bei deutschen Wirtschaftsverb{\"a}nden},
  publisher = {Lit},
  address   = {Berlin},
  isbn      = {978-3-64314-296-2},
  school      = {Universit{\"a}t Potsdam},
  pages     = {231},
  year      = {2019},
  abstract  = {Die deutschen Wirtschaftsverb{\"a}nde geraten zunehmend unter Konkurrenzdruck. Immer mehr Verb{\"a}nde werben um dieselbe Mitgliederklientel und haben einen {\"a}hnlichen Themenzuschnitt. Dar{\"u}ber hinaus betreiben immer mehr Mitgliedsunternehmen eigene politische Interessenvertretung. Die vorliegende Studie untersucht auf der Grundlage des aus der Evolutionsbiologie stammenden Population Ecology-Ansatzes, wie die Verb{\"a}nde mit dieser Konkurrenz umgehen.},
  language  = {de}
}