@article{GrimmMeyerCzaplaetal.2013,
  author    = {Grimm, Christiane and Meyer, Thomas and Czapla, Sylvia and Nikolaus, J{\"o}rg and Scheidt, Holger A. and Vogel, Alexander and Herrmann, Andreas and Wessig, Pablo and Huster, Daniel and M{\"u}ller, Peter},
  title     = {Structure and dynamics of molecular rods in membranes application of a Spin-Labeled rod},
  series = {Chemistry - a European journal},
  volume    = {19},
  journal   = {Chemistry - a European journal},
  number    = {8},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0947-6539},
  doi       = {10.1002/chem.201202500},
  pages     = {2703 -- 2710},
  year      = {2013},
  abstract  = {Molecular rods consisting of a hydrophobic backbone and terminally varying functional groups have been synthesized for applications for the functionalization of membranes. In the present study, we employ a spin-labeled analogue of a recently described new class of molecular rods to characterize their dynamic interactions with membranes. By using the different approaches of ESR and NMR spectroscopy, we show that the spin moiety of the membrane-embedded spin-labeled rod is localized in the upper chain/glycerol region of membranes of different compositions. The rod is embedded within the membrane in a tilted orientation to adjust for the varying hydrophobic thicknesses of these bilayers. This orientation does not perturb the membrane structure. The water solubility of the rod is increased significantly in the presence of certain cyclodextrins. These cyclodextrins also allow the rods to be extracted from the membrane and incorporated into preformed membranes. The latter will improve the future applications of these rods in cellular systems as stable membrane-associated anchors for the functionalization of membrane surfaces.},
  language  = {en}
}
@inproceedings{HaralampievMertensSchwarzeretal.2015,
  author    = {Haralampiev, Ivan and Mertens, Monique and Schwarzer, Roland and Herrmann, Andreas and Volkmer, Rudolf and Wessig, Pablo and M{\"u}ller, Peter},
  title     = {A palmitic acid functionalized with a maleimide group is used to recruit SH-containing peptides to lipid and biological membranes},
  series = {The FEBS journal},
  volume    = {282},
  booktitle = {The FEBS journal},
  publisher = {Wiley-Blackwell},
  address   = {Hoboken},
  issn      = {1742-464X},
  pages     = {204 -- 204},
  year      = {2015},
  language  = {en}
}
@article{MertensHilschHaralampievetal.2018,
  author    = {Mertens, Monique and Hilsch, Malte and Haralampiev, Ivan and Volkmer, Rudolf and Wessig, Pablo and M{\"u}ller, Peter},
  title     = {Synthesis and characterization of a new Bifunctionalized, Fluorescent, and Amphiphilic molecule for recruiting SH-Containing molecules to membranes},
  series = {ChemBioChem},
  volume    = {19},
  journal   = {ChemBioChem},
  number    = {15},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1439-4227},
  doi       = {10.1002/cbic.201800268},
  pages     = {1643 -- 1647},
  year      = {2018},
  abstract  = {This study describes the synthesis and characterization of an amphiphilic construct intended to recruit SH-containing molecules to membranes. The construct consists of 1)an aliphatic chain to enable anchoring within membranes, 2)a maleimide moiety to react with the sulfhydryl group of a soluble (bio)molecule, and 3)a fluorescence moiety to allow the construct to be followed by fluorescence spectroscopy and microscopy. It is shown that the construct can be incorporated into preformed membranes, thus allowing application of the approach with biological membranes. The close proximity between the fluorophore and the maleimide moiety within the construct causes fluorescence quenching. This allows monitoring of the reaction with SH-containing molecules by measurement of increases in fluorescence intensity and lifetime. Notably, the construct distributes into laterally ordered membrane domains of lipid vesicles, which is probably triggered by the length of its membrane anchor. The advantages of the new construct can be employed for several biological, biotechnological, and medicinal applications.},
  language  = {en}
}
@article{MuellerNikolausSchilleretal.2009,
  author    = {M{\"u}ller, Peter and Nikolaus, J{\"o}rg and Schiller, Sabine and Herrmann, Andreas and Moellnitz, Kristian and Czapla, Sylvia and Wessig, Pablo},
  title     = {Molecular rods with oligospiroketal backbones as anchors in biological membranes},
  issn      = {1433-7851},
  doi       = {10.1002/anie.200901133},
  year      = {2009},
  abstract  = {Getting stuck in: A hydrophobic molecular rod with terminal fluorescent moieties has been synthesized. The insertion of the rod into membranes was investigated and shown to incorporate efficiently into model and biological membranes (see picture; gray C, blue N, red O). Those rods can be used as stable membrane-associated anchors for functionalization of membrane surfaces.},
  language  = {en}
}
@article{NikolausCzaplaMoellnitzetal.2011,
  author    = {Nikolaus, J{\"o}rg and Czapla, Sylvia and M{\"o}llnitz, Kristian and H{\"o}fer, Chris T. and Herrmann, Andreas and Wessig, Pablo and M{\"u}ller, Peter},
  title     = {New molecular rods - Characterization of their interaction with membranes},
  series = {Biochimica et biophysica acta : Biomembranes},
  volume    = {1808},
  journal   = {Biochimica et biophysica acta : Biomembranes},
  number    = {12},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0005-2736},
  doi       = {10.1016/j.bbamem.2011.08.008},
  pages     = {2781 -- 2788},
  year      = {2011},
  abstract  = {Molecular rods are synthetical molecules consisting of a hydrophobic backbone which are functionalized with varying terminal groups. Here, we report on the interaction of a recently described new class of molecular rods with lipid and biological membranes. In order to characterize this interaction, different fluorescently labeled rods were synthesized allowing for the application of fluorescence spectroscopy and microscopy based approaches. Our data show that the rods are incorporated into membranes with a perpendicular orientation to the membrane surface and enrich preferentially in liquid-disordered lipid domains. These characteristics underline that rods can be applied as stable membrane-associated anchors for functionalizing membrane surfaces.},
  language  = {en}
}
@article{WawrzinekWessigMoellnitzetal.2012,
  author    = {Wawrzinek, Robert and Wessig, Pablo and M{\"o}llnitz, Kristian and Nikolaus, Joerg and Schwarzer, Roland and M{\"u}ller, Peter and Herrmann, Andreas},
  title     = {DBD dyes as fluorescent probes for sensing lipophilic environments},
  series = {Bioorganic \& medicinal chemistry letters : a Tetrahedron publication for rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry and related disciplines},
  volume    = {22},
  journal   = {Bioorganic \& medicinal chemistry letters : a Tetrahedron publication for rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry and related disciplines},
  number    = {17},
  publisher = {Elsevier},
  address   = {Oxford},
  issn      = {0960-894X},
  doi       = {10.1016/j.bmcl.2012.07.056},
  pages     = {5367 -- 5371},
  year      = {2012},
  abstract  = {Small fluorescent organic molecules based on [1,3]dioxolo[4,5-f][1,3]benzodioxole (DBD) could be used as probes for lipophillic microenvironments in aqueous solutions by indicating the critical micelles concentration of detergents and staining cell organelles. Their fluorescence lifetime decreases drastically by the amount of water in their direct environment. Therefore they are potential probes for fluorescence lifetime imaging microscopy (FLIM).},
  language  = {en}
}