@article{BeckmannKadowSchumacheretal.2018, author = {Beckmann, Nadine and Kadow, Stephanie and Schumacher, Fabian and Goethert, Joachim R. and Kesper, Stefanie and Draeger, Annette and Schulz-Schaeffer, Walter J. and Wang, Jiang and Becker, Jan U. and Kramer, Melanie and Kuehn, Claudine and Kleuser, Burkhard and Becker, Katrin Anne and Gulbins, Erich and Carpinteiro, Alexander}, title = {Pathological manifestations of Farber disease in a new mouse model}, series = {Biological chemistry}, volume = {399}, journal = {Biological chemistry}, number = {10}, publisher = {De Gruyter}, address = {Berlin}, issn = {1431-6730}, doi = {10.1515/hsz-2018-0170}, pages = {1183 -- 1202}, year = {2018}, abstract = {Farber disease (FD) is a rare lysosomal storage disorder resulting from acid ceramidase deficiency and subsequent ceramide accumulation. No treatments are clinically available and affected patients have a severely shortened lifespan. Due to the low incidence, the pathogenesis of FD is still poorly understood. Here, we report a novel acid ceramidase mutant mouse model that enables the study of pathogenic mechanisms of FD and ceramide accumulation. Asah1(tmEx1) mice were generated by deletion of the acid ceramidase signal peptide sequence. The effects on lysosomal targeting and activity of the enzyme were assessed. Ceramide and sphingomyelin levels were quantified by liquid chromatography tandem-mass spectrometry (LC-MS/MS) and disease manifestations in several organ systems were analyzed by histology and biochemistry. We show that deletion of the signal peptide sequence disrupts lysosomal targeting and enzyme activity, resulting in ceramide and sphingomyelin accumulation. The affected mice fail to thrive and die early. Histiocytic infiltrations were observed in many tissues, as well as lung inflammation, liver fibrosis, muscular disease manifestations and mild kidney injury. Our new mouse model mirrors human FD and thus offers further insights into the pathogenesis of this disease. In the future, it may also facilitate the development of urgently needed therapies.}, language = {en} } @article{BeermannWestburyHofreiteretal.2018, author = {Beermann, Jan and Westbury, Michael V. and Hofreiter, Michael and Hilgers, Leon and Deister, Fabian and Neumann, Hermann and Raupach, Michael J.}, title = {Cryptic species in a well-known habitat}, series = {Scientific reports}, volume = {8}, journal = {Scientific reports}, publisher = {Nature Publ. Group}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-018-25225-x}, pages = {26}, year = {2018}, abstract = {Taxonomy plays a central role in biological sciences. It provides a communication system for scientists as it aims to enable correct identification of the studied organisms. As a consequence, species descriptions should seek to include as much available information as possible at species level to follow an integrative concept of 'taxonomics'. Here, we describe the cryptic species Epimeria frankei sp. nov. from the North Sea, and also redescribe its sister species, Epimeria cornigera. The morphological information obtained is substantiated by DNA barcodes and complete nuclear 18S rRNA gene sequences. In addition, we provide, for the first time, full mitochondrial genome data as part of a metazoan species description for a holotype, as well as the neotype. This study represents the first successful implementation of the recently proposed concept of taxonomics, using data from high-throughput technologies for integrative taxonomic studies, allowing the highest level of confidence for both biodiversity and ecological research.}, language = {en} } @article{BehrendtSchlaad2018, author = {Behrendt, Felix Nicolas and Schlaad, Helmut}, title = {Entropy-Driven Ring-Opening Disulfide Metathesis Polymerization for the Synthesis of Functional Poly(disulfide)s}, series = {Macromolecular rapid communications}, volume = {39}, journal = {Macromolecular rapid communications}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1022-1336}, doi = {10.1002/marc.201700735}, pages = {4}, year = {2018}, abstract = {Metal-free entropy-driven disulfide metathesis polymerization of unsaturated L-cystine based macrocycles produces high-molar-mass heterofunctional poly(disulfide)s, i.e., poly(ester-disulfide-alkene) and poly(amide-disulfide-alkene); M-w(app) = 44-60 kDa, (sic) > 1.7. The polymerization is fast and reaches equilibrium within 1-5 minutes (monomer conversion 70-90\%) in polar aprotic solvents such as N,N-dimethylacetamide, dimethylsulfoxide, or y-valerolactone. Thiol-terminated polymers are stable in bulk or when dissolved in weakly polar solvents, but rapidly depolymerize in dilute polar solution.}, language = {en} } @article{BellmannCaliendoTuebbicke2018, author = {Bellmann, Lutz and Caliendo, Marco and T{\"u}bbicke, Stefan}, title = {The post-reform effectiveness of the new German start-up subsidy for the unemployed}, series = {Labour-England}, volume = {32}, journal = {Labour-England}, number = {3}, publisher = {Wiley}, address = {Hoboken}, issn = {1121-7081}, doi = {10.1111/labr.12126}, pages = {293 -- 319}, year = {2018}, abstract = {The current German start-up subsidy for unemployed individuals underwent a major reform in 2011 that altered key parameters of the program, leading to ambiguous ex ante predictions on the post-reform effectiveness of the program, making a new evaluation necessary. In our descriptive analysis, we find that participants after the reform differ significantly from pre-reform participants in terms of important characteristics and subsequent labor market performance. Our causal analysis reveals positive and sizable treatment effects on the treated regarding employment and income that are larger effects than what was estimated for the pre-reform program. Potential reasons for this are discussed.}, language = {en} } @article{BenardKlimmWoodlandetal.2018, author = {Benard, Antoine and Klimm, Kevin and Woodland, Alan B. and Arculus, Richard J. and Wilke, Max and Botcharnikov, Roman E. and Shimizu, Nobumichi and Nebel, Oliver and Rivard, Camille and Ionov, Dmitri A.}, title = {Oxidising agents in sub-arc mantle melts link slab devolatilisation and arc magmas}, series = {Nature Communications}, volume = {9}, journal = {Nature Communications}, publisher = {Nature Publ. Group}, address = {London}, issn = {2041-1723}, doi = {10.1038/s41467-018-05804-2}, pages = {10}, year = {2018}, abstract = {Subduction zone magmas are more oxidised on eruption than those at mid-ocean ridges. This is attributed either to oxidising components, derived from subducted lithosphere (slab) and added to the mantle wedge, or to oxidation processes occurring during magma ascent via differentiation. Here we provide direct evidence for contributions of oxidising slab agents to melts trapped in the sub-arc mantle. Measurements of sulfur (S) valence state in sub-arc mantle peridotites identify sulfate, both as crystalline anhydrite (CaSO4) and dissolved SO42- in spinel-hosted glass (formerly melt) inclusions. Copper-rich sulfide precipitates in the inclusions and increased Fe3+/Sigma Fe in spinel record a S6+-Fe2+ redox coupling during melt percolation through the sub-arc mantle. Sulfate-rich glass inclusions exhibit high U/Th, Pb/Ce, Sr/Nd and delta S-34 (+ 7 to + 11\%), indicating the involvement of dehydration products of serpentinised slab rocks in their parental melt sources. These observations provide a link between liberated slab components and oxidised arc magmas.}, language = {en} } @article{BenduhnPiersimoniLondietal.2018, author = {Benduhn, Johannes and Piersimoni, Fortunato and Londi, Giacomo and Kirch, Anton and Widmer, Johannes and Koerner, Christian and Beljonne, David and Neher, Dieter and Spoltore, Donato and Vandewal, Koen}, title = {Impact of triplet excited states on the open-circuit voltage of organic solar cells}, series = {dvanced energy materials}, volume = {8}, journal = {dvanced energy materials}, number = {21}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1614-6832}, doi = {10.1002/aenm.201800451}, pages = {7}, year = {2018}, abstract = {The best organic solar cells (OSCs) achieve comparable peak external quantum efficiencies and fill factors as conventional photovoltaic devices. However, their voltage losses are much higher, in particular those due to nonradiative recombination. To investigate the possible role of triplet states on the donor or acceptor materials in this process, model systems comprising Zn- and Cu-phthalocyanine (Pc), as well as fluorinated versions of these donors, combined with C-60 as acceptor are studied. Fluorination allows tuning the energy level alignment between the lowest energy triplet state (T-1) and the charge-transfer (CT) state, while the replacement of Zn by Cu as the central metal in the Pcs leads to a largely enhanced spin-orbit coupling. Only in the latter case, a substantial influence of the triplet state on the nonradiative voltage losses is observed. In contrast, it is found that for a large series of typical OSC materials, the relative energy level alignment between T-1 and the CT state does not substantially affect nonradiative voltage losses.}, language = {en} } @article{BeniniSchenkelSchreiber2018, author = {Benini, Marco and Schenkel, Alexander and Schreiber, Urs}, title = {The Stack of Yang-Mills Fields on Lorentzian Manifolds}, series = {Communications in mathematical physics}, volume = {359}, journal = {Communications in mathematical physics}, number = {2}, publisher = {Springer}, address = {New York}, issn = {0010-3616}, doi = {10.1007/s00220-018-3120-1}, pages = {765 -- 820}, year = {2018}, abstract = {We provide an abstract definition and an explicit construction of the stack of non-Abelian Yang-Mills fields on globally hyperbolic Lorentzian manifolds. We also formulate a stacky version of the Yang-Mills Cauchy problem and show that its well-posedness is equivalent to a whole family of parametrized PDE problems. Our work is based on the homotopy theoretical approach to stacks proposed in Hollander (Isr. J. Math. 163:93-124, 2008), which we shall extend by further constructions that are relevant for our purposes. In particular, we will clarify the concretification of mapping stacks to classifying stacks such as BG (con).}, language = {en} } @article{BentsGrothSatake2018, author = {Bents, Dominik and Groth, Detlef and Satake, Takashi}, title = {The secular trend and network effects on height of male Japanese students from 1955 to 2015}, series = {Journal of biological and clinical anthropology}, volume = {74}, journal = {Journal of biological and clinical anthropology}, number = {5}, publisher = {Schweizerbart}, address = {Stuttgart}, issn = {0003-5548}, doi = {10.1127/anthranz/2018/0838}, pages = {423 -- 429}, year = {2018}, abstract = {Introduction: Body height is influenced by biological factors such as genetics, nutrition and health, but also by the social network, and environmental and economical factors. During centuries, the Japanese society has developed on islands. This setting provides ideal natural conditions for studying the influence of social networks on human height. Material and methods: We investigated body height of male Japanese students aged 17.5 years obtained in 47 prefectures, from the Japanese school health survey of the years 1955, 1975, 1995, and 2015. Results: Japanese students increased in height from 163.23 cm in 1955 to 170.84 cm in 1995, with no further increase thereafter (170.63 cm in 2015). Students living in neighboring prefectures were similar in height. The correlation of height between neighboring prefectures ranged between r = 0.79 and r = 0.49 among first degree neighbors, between r = 0.49 and r = 0.21 among second degree neighbors and dropped to insignificance among third degree neighbors indicating psychosocial effects of the community on body height. Tall stature and short stature prefectures did not remain tall or short throughout history. Autocorrelations of height within the same prefectures decreased from the 20 years periods of 1955-1975, 1975-1995 and 1995-2015 (r = 0.52, r = 0.61, r = 0.63, respectively) to the 40 years periods of 1955-1995 and 1975-2015 (r = 0.49, r = 0.52), down to the 60 years period of 1955-2015 (r = 0.27), indicating significant volatility of height. Conclusion: Body height of 17.5 years old Japanese students increased since 1955. Body height depended on height of the neighboring prefecture, but was volatile with decreasing autocorrelation during a period of 60 years.}, language = {en} } @article{BerkesiCzupponSzaboetal.2018, author = {Berkesi, Marta and Czuppon, Gyorgy and Szabo, Csaba and Kovacs, Istvan and Ferrero, Silvio and Boiron, Marie-Christine and Peiffert, Chantal}, title = {Pargasite in fluid inclusions of mantle xenoliths from northeast Australia (Mt. Quincan)}, series = {Chemical geology : official journal of the European Association for Geochemistry}, volume = {508}, journal = {Chemical geology : official journal of the European Association for Geochemistry}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0009-2541}, doi = {10.1016/j.chemgeo.2018.06.022}, pages = {182 -- 196}, year = {2018}, abstract = {Three spinel lherzolite xenoliths from Mt. Quincan (Queensland, northeastern Australia) were studied with special attention to their enclosed fluid inclusions. The xenoliths are deformed, have porphyroclastic textures and overall show very similar petrographic features. The only significant difference is manifested in the abundance of fluid inclusions in the samples, mostly in orthopyroxene porphyroclasts. Xenolith JMTQ11 is fluid inclusion-free, whereas xenolith JMTQ20 shows a high abundance of fluid inclusions (fluid inclusion-rich). Xenolith JMTQ45 represents a transitional state between the previous two, as it contains only a small amount of fluid inclusions (fluid inclusion-bearing). Previous studies revealed that these xenoliths and the entrapped fluid inclusions represent a former addition of a MORB-type fluid to the pre-existing lithosphere, resulting from asthenosphere upwelling. There is a progressive enrichment in LREE, Nb, Sr and Ti from the fluid inclusion-free xenolith through the fluid inclusion-bearing one to the fluid inclusion-rich lherzolite. This suggests an increase in the extent of the interaction between the fluid-rich melt and the lherzolite wallrock. In addition, the same interaction is considered to be responsible for the formation of pargasitic amphibole as well. The presence of fluid inclusions indicates fluid migration at mantle depth, and their association with exsolution lamellae in orthopyroxene suggests fluid entrapment following the continental rifting (thermal relaxation) during cooling. A series of analyses, including microthermometry coupled with Raman spectroscopy, FTIR hyperspectral imaging, and Focused Ion Beam-Scanning Electron Microscopy (FIB-SEM) was carried out on the fluid inclusions. Based on the results, the entrapped high-density fluid is composed of 7589 mol\% CO2, 918 mol\% H2O, 0.11.7 mol\% N-2 and <= 0.5 mol\% H2S with dissolved trace elements (melt component). Our findings suggest that the metasomatic fluid phase could have been either a fluid/fluid-rich silicate melt released from the deeper asthenosphere, or a coexisting incipient fluid-rich silicate melt. Further cooling, possibly due to thermal relaxation and the upward migration of the fluid phase, caused the investigated lherzolites to reach pargasite stability conditions. We conclude that pargasite, even if only present in very limited modal proportions, can be a common phase at spinel lherzolite stability in the lithospheric upper mantle in continental rift back-arc settings. Studies of fluid inclusions indicate that significant CO2 release from the asthenosphere in a continental rifting environment is resulting from asthenosphere upwelling and its addition to the lithospheric mantle together with fluid-rich melt lherzolite interaction that leaves a CO2-rich fluid behind.}, language = {en} } @article{BerndtYildirimCineretal.2018, author = {Berndt, Christopher and Yildirim, Cengiz and Ciner, Attila and Strecker, Manfred and Ertunc, Gulgun and Sarikaya, M. Akif and {\"O}zcan, Orkan and Ozturk, Tugba and Kiyak, Nafiye Gunec}, title = {Quaternary uplift of the northern margin of the Central Anatolian Plateau}, series = {Quaternary science reviews : the international multidisciplinary research and review journal}, volume = {201}, journal = {Quaternary science reviews : the international multidisciplinary research and review journal}, publisher = {Elsevier}, address = {Oxford}, issn = {0277-3791}, doi = {10.1016/j.quascirev.2018.10.029}, pages = {446 -- 469}, year = {2018}, abstract = {We analysed the interplay between coastal uplift, sea level change in the Black Sea, and incision of the Kizilirmak River in northern Turkey. These processes have created multiple co-genetic fluvial and marine terrace sequences that serve as excellent strain markers to assess the ongoing evolution of the Pontide orogenic wedge and the growth of the northern margin of the Central Anatolian Plateau. We used high-resolution topographic data, OSL ages, and published information on past sea levels to analyse the spatiotemporal evolution of these terraces; we derived a regional uplift model for the northward advancing orogenic wedge that supports the notion of laterally variable uplift rates along the flanks of the Pontides. The best-fit uplift model defines a constant long-term uplift rate of 0.28 +/- 0.07 m/ka for the last 545 ka. This model explains the evolution of the terrace sequence in light of active tectonic processes and superposed cycles of climate-controlled sea-level change. Our new data reveal regional uplift characteristics that are comparable to the inner sectors of the Central Pontides; accordingly, the rate of uplift diminishes with increasing distance from the main strand of the restraining bend of the North Anatolian Fault Zone (NAFZ). This spatial relationship between the regional impact of the restraining bend of the NAFZ and uplift of the Pontide wedge thus suggests a strong link between the activity of the NAFZ, deformation and uplift in the Pontide orogenic wedge, and the sustained lateral growth of the Central Anatolian Plateau flank. (C) 2018 Elsevier Ltd. All rights reserved.}, language = {en} } @article{BernhardMoskwaSchmidtetal.2018, author = {Bernhard, Nadine and Moskwa, Lisa-Marie and Schmidt, Karsten and Oeser, Ralf Andreas and Aburto, Felipe and Bader, Maaike Y. and Baumann, Karen and von Blanckenburg, Friedhelm and Boy, Jens and van den Brink, Liesbeth and Brucker, Emanuel and Buedel, Burkhard and Canessa, Rafaella and Dippold, Michaela A. and Ehlers, Todd and Fuentes, Juan P. and Godoy, Roberto and Jung, Patrick and Karsten, Ulf and Koester, Moritz and Kuzyakov, Yakov and Leinweber, Peter and Neidhardt, Harald and Matus, Francisco and Mueller, Carsten W. and Oelmann, Yvonne and Oses, Romulo and Osses, Pablo and Paulino, Leandro and Samolov, Elena and Schaller, Mirjam and Schmid, Manuel and Spielvogel, Sandra and Spohn, Marie and Stock, Svenja and Stroncik, Nicole and Tielboerger, Katja and Uebernickel, Kirstin and Scholten, Thomas and Seguel, Oscar and Wagner, Dirk and K{\"u}hn, Peter}, title = {Pedogenic and microbial interrelations to regional climate and local topography}, series = {Catena : an interdisciplinary journal of soil science, hydrology, geomorphology focusing on geoecology and landscape evolution}, volume = {170}, journal = {Catena : an interdisciplinary journal of soil science, hydrology, geomorphology focusing on geoecology and landscape evolution}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0341-8162}, doi = {10.1016/j.catena.2018.06.018}, pages = {335 -- 355}, year = {2018}, abstract = {The effects of climate and topography on soil physico-chemical and microbial parameters were studied along an extensive latitudinal climate gradient in the Coastal Cordillera of Chile (26 degrees-38 degrees S). The study sites encompass arid (Pan de Azucar), semiarid (Santa Gracia), mediterranean (La Campana) and humid (Nahuelbuta) climates and vegetation, ranging from arid desert, dominated by biological soil crusts (biocrusts), semiarid shrubland and mediterranean sclerophyllous forest, where biocrusts are present but do have a seasonal pattern to temperate-mixed forest, where biocrusts only occur as an early pioneering development stage after disturbance. All soils originate from granitic parent materials and show very strong differences in pedogenesis intensity and soil depth. Most of the investigated physical, chemical and microbiological soil properties showed distinct trends along the climate gradient. Further, abrupt changes between the arid northernmost study site and the other semi-arid to humid sites can be shown, which indicate non-linearity and thresholds along the climate gradient. Clay and total organic carbon contents (TOC) as well as Ah horizons and solum depths increased from arid to humid climates, whereas bulk density (BD), pH values and base saturation (BS) decreased. These properties demonstrate the accumulation of organic matter, clay formation and element leaching as key-pedogenic processes with increasing humidity. However, the soils in the northern arid climate do not follow this overall latitudinal trend, because texture and BD are largely controlled by aeolian input of dust and sea salts spray followed by the formation of secondary evaporate minerals. Total soil DNA concentrations and TOC increased from arid to humid sites, while areal coverage by biocrusts exhibited an opposite trend. Relative bacterial and archaeal abundances were lower in the arid site, but for the other sites the local variability exceeds the variability along the climate gradient. Differences in soil properties between topographic positions were most pronounced at the study sites with the mediterranean and humid climate, whereas microbial abundances were independent on topography across all study sites. In general, the regional climate is the strongest controlling factor for pedogenesis and microbial parameters in soils developed from the same parent material. Topographic position along individual slopes of limited length augmented this effect only under humid conditions, where water erosion likely relocated particles and elements downward. The change from alkaline to neutral soil pH between the arid and the semi-arid site coincided with qualitative differences in soil formation as well as microbial habitats. This also reflects non-linear relationships of pedogenic and microbial processes in soils depending on climate with a sharp threshold between arid and semi-arid conditions. Therefore, the soils on the transition between arid and semi-arid conditions are especially sensitive and may be well used as indicators of long and medium-term climate changes. Concluding, the unique latitudinal precipitation gradient in the Coastal Cordillera of Chile is predestined to investigate the effects of the main soil forming factor - climate - on pedogenic processes.}, language = {en} } @article{BertiEquilleHarmouchNaumannetal.2018, author = {Berti-Equille, Laure and Harmouch, Nazar and Naumann, Felix and Novelli, Noel and Saravanan, Thirumuruganathan}, title = {Discovery of genuine functional dependencies from relational data with missing values}, series = {Proceedings of the VLDB Endowment}, volume = {11}, journal = {Proceedings of the VLDB Endowment}, number = {8}, publisher = {Association for Computing Machinery}, address = {New York}, issn = {2150-8097}, doi = {10.14778/3204028.3204032}, pages = {880 -- 892}, year = {2018}, abstract = {Functional dependencies (FDs) play an important role in maintaining data quality. They can be used to enforce data consistency and to guide repairs over a database. In this work, we investigate the problem of missing values and its impact on FD discovery. When using existing FD discovery algorithms, some genuine FDs could not be detected precisely due to missing values or some non-genuine FDs can be discovered even though they are caused by missing values with a certain NULL semantics. We define a notion of genuineness and propose algorithms to compute the genuineness score of a discovered FD. This can be used to identify the genuine FDs among the set of all valid dependencies that hold on the data. We evaluate the quality of our method over various real-world and semi-synthetic datasets with extensive experiments. The results show that our method performs well for relatively large FD sets and is able to accurately capture genuine FDs.}, language = {en} } @article{BindiCottonSpallarossaetal.2018, author = {Bindi, Dino and Cotton, Fabrice and Spallarossa, Daniele and Picozzi, Matteo and Rivalta, Eleonora}, title = {Temporal variability of ground shaking and stress drop in Central Italy}, series = {Bulletin of the Seismological Society of America}, volume = {108}, journal = {Bulletin of the Seismological Society of America}, number = {4}, publisher = {Seismological Society of America}, address = {Albany}, issn = {0037-1106}, doi = {10.1785/0120180078}, pages = {1853 -- 1863}, year = {2018}, abstract = {Ground-motion prediction equations (GMPEs) are calibrated to predict the intensity of ground shaking at any given location, based on earthquake magnitude, source-to-site distance, local soil amplifications, and other parameters. GMPEs are generally assumed to be independent of time; however, evidence is increasing that large earthquakes modify the shallow soil conditions and those of the fault zone for months or years. These changes may affect the intensity of shaking and result in time-dependent effects that can potentially be resolved by analyzing between-event residuals (residuals between observed and predicted ground motion for individual earthquakes averaged over all stations). Here, we analyze a data set of about 65,000 recordings for about 1400 earthquakes in the moment magnitude range 2.5-6.5 that occurred in central Italy from 2008 to 2017 to capture the temporal variability of the ground shaking at high frequency. We first compute between-event residuals for each earthquake in the Fourier domain with respect to a GMPE developed ad hoc for the analyzed data set. The between-events show large changes after the occurrence of mainshocks such as the 2009 Mw 6.3 L'Aquila, the 2016 Mw 6.2 Amatrice, and Mw 6.5 Norcia earthquakes. Within the time span of a few months after the mainshocks, the between-event contribution to the ground shaking varies by a factor 7. In particular, we find a large drop in the between-events in the aftermath of the L'Aquila earthquake, followed by a slow positive trend that leads to a recovery interrupted by a new drop at the beginning of 2014. We also quantify the frequency-dependent correlation between the Brune stress drop Δσ and the between-events. We find that the temporal changes of Δσ resemble those of the between-event residuals; in particular, during the period when the between-events show the positive trend, the average logarithm of Δσ increases with an annual rate of 0.19 (i.e., the amplification factor for Δσ is 1.56 per year). Breakpoint analysis located a change in the linear trend coefficients of Δσ versus time in February 2014, although no large earthquakes occurred at that time. Finally, the temporal variability of Δσ mirrors the relative seismic-velocity variations observed in previous studies for the same area and period, suggesting that both crack healing along the main fault system and healing of microcracks distributed at shallow depths throughout the surrounding region might be necessary to explain the wider observations of postearthquake recovery.}, language = {en} } @article{BindiKothaWeatherilletal.2018, author = {Bindi, Dino and Kotha, Sreeram Reddy and Weatherill, Graeme and Lanzano, Giovanni and Luzi, Lucia and Cotton, Fabrice}, title = {The pan-European engineering strong motion (ESM) flatfile}, series = {Bulletin of earthquake engineering : official publication of the European Association for Earthquake Engineering}, volume = {17}, journal = {Bulletin of earthquake engineering : official publication of the European Association for Earthquake Engineering}, number = {2}, publisher = {Springer}, address = {Dordrecht}, issn = {1570-761X}, doi = {10.1007/s10518-018-0466-x}, pages = {583 -- 602}, year = {2018}, abstract = {We present the results of a consistency check performed over the flatfile extracted from the engineering strong motion (ESM) database. The flatfile includes 23,014 recordings from 2179 earthquakes in the magnitude range from 3.5 to 7.8 that occurred since the 1970s in Europe and Middle East, as presented in the companion article by Lanzano et al. (Bull Earthq Eng, 2018a). The consistency check is developed by analyzing different residual distributions obtained from ad-hoc ground motion prediction equations for the absolute spectral acceleration (SA), displacement and Fourier amplitude spectra (FAS). Only recordings from earthquakes shallower than 40 km are considered in the analysis. The between-event, between-station and event-and-station corrected residuals are computed by applying a mixed-effect regression. We identified those earthquakes, stations, and recordings showing the largest deviations from the GMPE median predictions, and also evaluated the statistical uncertainty on the median model to get insights on the applicable magnitude-distance ranges and the usable period (or frequency) range. We observed that robust median predictions are obtained up to 8 s for SA and up to 20 Hz for FAS, although median predictions for Mw ≥ 7 show significantly larger uncertainties with 'bumps' starting above 5 s for SA and below 0.3 Hz for FAS. The between-station variance dominates over the other residual variances, and the dependence of the between-station residuals on logarithm of Vs30 is well-described by a piece-wise linear function with period-dependent slopes and hinge velocity around 580 m/s. Finally, we compared the between-event residuals obtained by considering two different sources of moment magnitude. The results show that, at long periods, the between-event terms from the two regressions have a weak correlation and the overall between-event variability is dissimilar, highlighting the importance of magnitude source in the regression results.}, language = {en} } @article{BindiSpallarossaPicozzietal.2018, author = {Bindi, Dino and Spallarossa, D. and Picozzi, M. and Scafidi, D. and Cotton, Fabrice}, title = {Impact of magnitude selection on aleatory variability associated with ground-motion prediction equations}, series = {Bulletin of the Seismological Society of America}, volume = {108}, journal = {Bulletin of the Seismological Society of America}, number = {3A}, publisher = {Seismological Society of America}, address = {Albany}, issn = {0037-1106}, doi = {10.1785/0120170356}, pages = {1427 -- 1442}, year = {2018}, abstract = {In this study, we analyzed 10 yrs of seismicity in central Italy from 2008 to 2017, a period witnessing more than 1400 earthquakes in the magnitude range 2.5≤Mw≤6.5⁠. The data set includes the main sequences that have occurred in the area, including those associated with the 2009 Mw 6.3 L'Aquila earthquake and the 2016-2017 sequence (⁠Mw 6.2 Amatrice, Mw 6.1 Visso, and Mw 6.5 Norcia earthquakes). We calibrated a local magnitude scale, investigating the impact of changing the reference distance at which the nonparametric attenuation is tied to the zero-magnitude attenuation function for southern California. We also developed an attenuation model to compute the radiated seismic energy (⁠Es⁠) from the time integral of the squared ground-motion velocity. Seismic moment (⁠M0⁠) and stress drop (⁠Δσ⁠) were estimated for each earthquake by fitting a ω-square model to the source spectra obtained by applying a nonparametric spectral inversion. The Δσ-values vary over three orders of magnitude from about 0.1 to 10 MPa, the larger values associated with the mainshocks. The Δσ-values describe a lognormal distribution with mean and standard deviation equal to log(Δσ)=(-0.25±0.45) (i.e., the mean Δσ is 0.57 MPa, with a 95\% confidence interval from 0.08 to 4.79 MPa). The Δσ variability introduces a spread in the distribution of seismic energy versus moment, with differences in energy up two orders of magnitudes for earthquakes with the same moment. The variability in the high-frequency spectral levels is captured by the local magnitude (⁠ML⁠), which scales with radiated energy as ML=(-1.59+0.52logEs) for logEs≤10.26 and ML=(-1.38+0.50logEs) otherwise. As the peak ground velocity increases with increasing Δσ⁠, local and energy magnitudes perform better than moment magnitude as predictors for the shaking potential. The availability of different magnitude scales and source parameters for a large earthquake population will help characterize the between-event ground-motion variability in central Italy.}, language = {en} } @article{BiswasHermanKingetal.2018, author = {Biswas, R. H. and Herman, F. and King, G. E. and Braun, Jean}, title = {Thermoluminescence of feldspar as a multi-thermochronometer to constrain the temporal variation of rock exhumation in the recent past}, series = {Earth \& planetary science letters}, volume = {495}, journal = {Earth \& planetary science letters}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0012-821X}, doi = {10.1016/j.epsl.2018.04.030}, pages = {56 -- 68}, year = {2018}, abstract = {Natural thermoluminescence (TL) in rocks reflects a dynamic equilibrium between radiation-induced TL growth and decay via thermal and athermal pathways. When rocks exhume through Earth's crust and cool from high to low temperature, this equilibrium level increases as the temperature dependent thermal decay decreases. This phenomenon can be exploited to extract thermal histories of rocks. The main advantage of TL is that a single TL glow curve has a wide range of thermal stabilities (lifetime 100 °C/Ma, whereas deeper traps, i.e. with higher activation energies, provide constraints on thermal histories for higher cooling rates (>300 °C/Ma). Finally, we show how the path of rock exhumation (i.e., depth vs. time) can be constrained using an inverse approach. The newly developed methodology is applied to rapidly cooled samples from the Namche Barwa massif, eastern Himalaya to suggest a trend in exhumation rate with time that follows an inverse correlation with global temperature and glaciers equilibrium altitude line (ELA).}, language = {en} } @article{BiterovaEsmaeeliMoghaddamTabalvandaniAlanenetal.2018, author = {Biterova, Ekaterina and Esmaeeli Moghaddam Tabalvandani, Mariam and Alanen, Heli I. and Saaranen, Mirva and Ruddock, Lloyd W.}, title = {Structures of Angptl3 and Angptl4, modulators of triglyceride levels and coronary artery disease}, series = {Scientific reports}, volume = {8}, journal = {Scientific reports}, publisher = {Nature Publ. Group}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-018-25237-7}, pages = {12}, year = {2018}, abstract = {Coronary artery disease is the most common cause of death globally and is linked to a number of risk factors including serum low density lipoprotein, high density lipoprotein, triglycerides and lipoprotein(a). Recently two proteins, angiopoietin-like protein 3 and 4, have emerged from genetic studies as being factors that significantly modulate plasma triglyceride levels and coronary artery disease. The exact function and mechanism of action of both proteins remains to be elucidated, however, mutations in these proteins results in up to 34\% reduction in coronary artery disease and inhibition of function results in reduced plasma triglyceride levels. Here we report the crystal structures of the fibrinogen-like domains of both proteins. These structures offer new insights into the reported loss of function mutations, the mechanisms of action of the proteins and open up the possibility for the rational design of low molecular weight inhibitors for intervention in coronary artery disease.}, language = {en} } @article{BizicIonescuIonescuGrossart2018, author = {Bizic-Ionescu, Mina and Ionescu, Danny and Grossart, Hans-Peter}, title = {Organic Particles: Heterogeneous Hubs for Microbial Interactions in Aquatic Ecosystems}, series = {Frontiers in microbiology}, volume = {9}, journal = {Frontiers in microbiology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-302X}, doi = {10.3389/fmicb.2018.02569}, pages = {15}, year = {2018}, abstract = {The dynamics and activities of microbes colonizing organic particles (hereafter particles) greatly determine the efficiency of the aquatic carbon pump. Current understanding is that particle composition, structure and surface properties, determined mostly by the forming organisms and organic matter, dictate initial microbial colonization and the subsequent rapid succession events taking place as organic matter lability and nutrient content change with microbial degradation. We applied a transcriptomic approach to assess the role of stochastic events on initial microbial colonization of particles. Furthermore, we asked whether gene expression corroborates rapid changes in carbon-quality. Commonly used size fractionated filtration averages thousands of particles of different sizes, sources, and ages. To overcome this drawback, we used replicate samples consisting each of 3-4 particles of identical source and age and further evaluated the consequences of averaging 10-1000s of particles. Using flow-through rolling tanks we conducted long-term experiments at near in situ conditions minimizing the biasing effects of closed incubation approaches often referred to as "the bottle-effect." In our open flow-through rolling tank system, however, active microbial communities were highly heterogeneous despite an identical particle source, suggesting random initial colonization. Contrasting previous reports using closed incubation systems, expression of carbon utilization genes didn't change after 1 week of incubation. Consequently, we suggest that in nature, changes in particle-associated community related to carbon availability are much slower (days to weeks) due to constant supply of labile, easily degradable organic matter. Initial, random particle colonization seems to be subsequently altered by multiple organismic interactions shaping microbial community interactions and functional dynamics. Comparative analysis of thousands particles pooled togethers as well as pooled samples suggests that mechanistic studies of microbial dynamics should be done on single particles. The observed microbial heterogeneity and inter-organismic interactions may have important implications for evolution and biogeochemistry in aquatic systems.}, language = {en} } @article{BlanchardCarpentierGutzeit2018, author = {Blanchard, Gilles and Carpentier, Alexandra and Gutzeit, Maurilio}, title = {Minimax Euclidean separation rates for testing convex hypotheses in R-d}, series = {Electronic journal of statistics}, volume = {12}, journal = {Electronic journal of statistics}, number = {2}, publisher = {Institute of Mathematical Statistics}, address = {Cleveland}, issn = {1935-7524}, doi = {10.1214/18-EJS1472}, pages = {3713 -- 3735}, year = {2018}, abstract = {We consider composite-composite testing problems for the expectation in the Gaussian sequence model where the null hypothesis corresponds to a closed convex subset C of R-d. We adopt a minimax point of view and our primary objective is to describe the smallest Euclidean distance between the null and alternative hypotheses such that there is a test with small total error probability. In particular, we focus on the dependence of this distance on the dimension d and variance 1/n giving rise to the minimax separation rate. In this paper we discuss lower and upper bounds on this rate for different smooth and non-smooth choices for C.}, language = {en} } @article{BlanchardHoffmannReiss2018, author = {Blanchard, Gilles and Hoffmann, Marc and Reiss, Markus}, title = {Optimal adaptation for early stopping in statistical inverse problems}, series = {SIAM/ASA Journal on Uncertainty Quantification}, volume = {6}, journal = {SIAM/ASA Journal on Uncertainty Quantification}, number = {3}, publisher = {Society for Industrial and Applied Mathematics}, address = {Philadelphia}, issn = {2166-2525}, doi = {10.1137/17M1154096}, pages = {1043 -- 1075}, year = {2018}, abstract = {For linear inverse problems Y = A mu + zeta, it is classical to recover the unknown signal mu by iterative regularization methods ((mu) over cap,(m) = 0,1, . . .) and halt at a data-dependent iteration tau using some stopping rule, typically based on a discrepancy principle, so that the weak (or prediction) squared-error parallel to A((mu) over cap (()(tau)) - mu)parallel to(2) is controlled. In the context of statistical estimation with stochastic noise zeta, we study oracle adaptation (that is, compared to the best possible stopping iteration) in strong squared- error E[parallel to((mu) over cap (()(tau)) - mu)parallel to(2)]. For a residual-based stopping rule oracle adaptation bounds are established for general spectral regularization methods. The proofs use bias and variance transfer techniques from weak prediction error to strong L-2-error, as well as convexity arguments and concentration bounds for the stochastic part. Adaptive early stopping for the Landweber method is studied in further detail and illustrated numerically.}, language = {en} }