@article{OlejkoCywińskiBald2016, author = {Olejko, Lydia and Cywiński, Piotr J. and Bald, Ilko}, title = {An ion-controlled four-color fluorescent telomeric switch on DNA origami structures}, series = {Nanoscale}, volume = {8}, journal = {Nanoscale}, publisher = {RSC Publ.}, address = {Cambridge}, issn = {2040-3372}, doi = {10.1039/C6NR00119J}, pages = {10339 -- 10347}, year = {2016}, abstract = {The folding of single-stranded telomeric DNA into guanine (G) quadruplexes is a conformational change that plays a major role in sensing and drug targeting. The telomeric DNA can be placed on DNA origami nanostructures to make the folding process extremely selective for K+ ions even in the presence of high Na+ concentrations. Here, we demonstrate that the K+-selective G-quadruplex formation is reversible when using a cryptand to remove K+ from the G-quadruplex. We present a full characterization of the reversible switching between single-stranded telomeric DNA and G-quadruplex structures using F{\"o}rster resonance energy transfer (FRET) between the dyes fluorescein (FAM) and cyanine3 (Cy3). When attached to the DNA origami platform, the G-quadruplex switch can be incorporated into more complex photonic networks, which is demonstrated for a three-color and a four-color FRET cascade from FAM over Cy3 and Cy5 to IRDye700 with G-quadruplex-Cy3 acting as a switchable transmitter.}, language = {en} } @article{Khurana2022, author = {Khurana, Thomas}, title = {Gattungswesen}, series = {Deutsche Zeitschrift f{\"u}r Philosophie : Zweimonatsschrift der internationalen philosophischen Forschung}, volume = {70}, journal = {Deutsche Zeitschrift f{\"u}r Philosophie : Zweimonatsschrift der internationalen philosophischen Forschung}, number = {3}, publisher = {De Gruyter}, address = {Berlin}, issn = {0012-1045}, doi = {10.1515/dzph-2022-0023}, pages = {373 -- 399}, year = {2022}, abstract = {In which sense can human beings be conceived as social animals? To elucidate this question, the present paper (I) distinguishes the logical sociality of all living beings from the material sociality of social animals and the political sociality of self-conscious social animals. (II) The self-conscious political sociality that characterises the human genus-being requires a complex interplay of first and second person through which alone we can participate in our form of life and determine its content. (III) The human form of life thus constituted is characterised by a particularly open, and at the same time precarious, membership which involves specific forms of vulnerability and power. (IV) Against this background, forms of objective spirit are necessary which grant us a generalized recognition and relieve us from the contingency of each particular second-personal recognition, without abandoning the openness of the sociality of the human form of life. This double requirement has led to paradoxical institutions in modern society which strive to protect and ensure the sociality of the human form of life precisely by naturalising and individualising our access to it.}, language = {de} } @article{GiraudierVenturaBortWeymar2020, author = {Giraudier, Manon and Ventura-Bort, Carlos and Weymar, Mathias}, title = {Transcutaneous Vagus Nerve Stimulation (tVNS) Improves High-Confidence Recognition Memory but Not Emotional Word Processing}, series = {Frontiers in Psychology}, volume = {11}, journal = {Frontiers in Psychology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2020.01276}, pages = {13}, year = {2020}, abstract = {Previous clinical research found that invasive vagus nerve stimulation (VNS) enhanced word recognition memory in epileptic patients, an effect assumed to be related to the activation of brainstem arousal systems. In this study, we applied non-invasive transcutaneous auricular VNS (tVNS) to replicate and extend the previous work. Using a single-blind, randomized, between-subject design, 60 healthy volunteers received active or sham stimulation during a lexical decision task, in which emotional and neutral stimuli were classified as words or non-words. In a subsequent recognition memory task (1 day after stimulation), participants' memory performance on these words and their subjective memory confidence were tested. Salivary alpha-amylase (sAA) levels, a putative indirect measure of central noradrenergic activation, were also measured before and after stimulation. During encoding, pleasant words were more accurately detected than neutral and unpleasant words. However, no tVNS effects were observed on task performance or on overall sAA level changes. tVNS also did not modulate overall recognition memory, which was particularly enhanced for pleasant emotional words. However, when hit rates were split based on confidence ratings reflecting familiarity- and recollection-based memory, higher recollection-based memory performance (irrespective of emotional category) was observed during active stimulation than during sham stimulation. To summarize, we replicated prior findings of enhanced processing and memory for emotional (pleasant) words. Whereas tVNS showed no effects on word processing, subtle effects on recollection-based memory performance emerged, which may indicate that tVNS facilitates hippocampus-mediated consolidation processes.}, language = {en} } @article{CiaccioVerissimo2022, author = {Ciaccio, Laura Anna and Ver{\´i}ssimo, Jo{\~a}o}, title = {Investigating variability in morphological processing with Bayesian distributional models}, series = {Psychonomic bulletin \& review : a journal of the Psychonomic Society}, journal = {Psychonomic bulletin \& review : a journal of the Psychonomic Society}, publisher = {Springer}, address = {New York}, issn = {1069-9384}, doi = {10.3758/s13423-022-02109-w}, pages = {2264 -- 2274}, year = {2022}, abstract = {We investigated the processing of morphologically complex words adopting an approach that goes beyond estimating average effects and allows testing predictions about variability in performance. We tested masked morphological priming effects with English derived ('printer') and inflected ('printed') forms priming their stems ('print') in non-native speakers, a population that is characterized by large variability. We modeled reaction times with a shifted-lognormal distribution using Bayesian distributional models, which allow assessing effects of experimental manipulations on both the mean of the response distribution ('mu') and its standard deviation ('sigma'). Our results show similar effects on mean response times for inflected and derived primes, but a difference between the two on the sigma of the distribution, with inflectional priming increasing response time variability to a significantly larger extent than derivational priming. This is in line with previous research on non-native processing, which shows more variable results across studies for the processing of inflected forms than for derived forms. More generally, our study shows that treating variability in performance as a direct object of investigation can crucially inform models of language processing, by disentangling effects which would otherwise be indistinguishable. We therefore emphasize the importance of looking beyond average performance and testing predictions on other parameters of the distribution rather than just its central tendency.}, language = {en} } @article{BreedveldFolkertsmaEccard2019, author = {Breedveld, Merel Cathelijne and Folkertsma, Remco and Eccard, Jana}, title = {Rodent mothers increase vigilance behaviour when facing infanticide risk}, series = {Scientific Reports}, volume = {9}, journal = {Scientific Reports}, publisher = {Macmillan Publishers Limited, part of Springer Nature}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-019-48459-9}, pages = {10}, year = {2019}, abstract = {Infanticide, the killing of unrelated young, is widespread and frequently driven by sexual conflict. especially in mammals with exclusive maternal care, infanticide by males is common and females suffer fitness costs. Recognizing infanticide risk and adjusting offspring protection accordingly should therefore be adaptive in female mammals. Using a small mammal (Myodes glareolus) in outdoor enclosures, we investigated whether lactating mothers adjust offspring protection, and potential mate search behaviour, in response to different infanticide risk levels. We presented the scent of the litter's sire or of a stranger male near the female's nest, and observed female nest presence and movement by radiotracking. While both scents simulated a mating opportunity, they represented lower (sire) and higher (stranger) infanticide risk. compared to the sire treatment, females in the stranger treatment left their nest more often, showed increased activity and stayed closer to the nest, suggesting offspring protection from outside the nest through elevated alertness and vigilance. females with larger litters spent more time investigating scents and used more space in the sire but not in the stranger treatment. Thus, current investment size affected odour inspection and resource acquisition under higher risk. Adjusting nest protection and resource acquisition to infanticide risk could allow mothers to elicit appropriate (fitness-saving) counterstrategies, and thus, may be widespread.}, language = {en} }