@article{BirukovCuadratPolemitietal.2021, author = {Birukov, Anna and Cuadrat, Rafael R. C. and Polemiti, Elli and Eichelmann, Fabian and Schulze, Matthias Bernd}, title = {Advanced glycation end-products, measured as skin autofluorescence, associate with vascular stiffness in diabetic, pre-diabetic and normoglycemic individuals}, series = {Cardiovascular diabetology}, volume = {20}, journal = {Cardiovascular diabetology}, number = {1}, publisher = {BioMed Central}, address = {London}, issn = {1475-2840}, doi = {10.1186/s12933-021-01296-5}, pages = {11}, year = {2021}, abstract = {Background Advanced glycation end-products are proteins that become glycated after contact with sugars and are implicated in endothelial dysfunction and arterial stiffening. We aimed to investigate the relationships between advanced glycation end-products, measured as skin autofluorescence, and vascular stiffness in various glycemic strata. Methods We performed a cross-sectional analysis within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort, comprising n = 3535 participants (median age 67 years, 60\% women). Advanced glycation end-products were measured as skin autofluorescence with AGE-Reader (TM), vascular stiffness was measured as pulse wave velocity, augmentation index and ankle-brachial index with Vascular Explorer (TM). A subset of 1348 participants underwent an oral glucose tolerance test. Participants were sub-phenotyped into normoglycemic, prediabetes and diabetes groups. Associations between skin autofluorescence and various indices of vascular stiffness were assessed by multivariable regression analyses and were adjusted for age, sex, measures of adiposity and lifestyle, blood pressure, prevalent conditions, medication use and blood biomarkers. Results Skin autofluorescence associated with pulse wave velocity, augmentation index and ankle-brachial index, adjusted beta coefficients (95\% CI) per unit skin autofluorescence increase: 0.38 (0.21; 0.55) for carotid-femoral pulse wave velocity, 0.25 (0.14; 0.37) for aortic pulse wave velocity, 1.00 (0.29; 1.70) for aortic augmentation index, 4.12 (2.24; 6.00) for brachial augmentation index and - 0.04 (- 0.05; - 0.02) for ankle-brachial index. The associations were strongest in men, younger individuals and were consistent across all glycemic strata: for carotid-femoral pulse wave velocity 0.36 (0.12; 0.60) in normoglycemic, 0.33 (- 0.01; 0.67) in prediabetes and 0.45 (0.09; 0.80) in diabetes groups; with similar estimates for aortic pulse wave velocity. Augmentation index was associated with skin autofluorescence only in normoglycemic and diabetes groups. Ankle-brachial index inversely associated with skin autofluorescence across all sex, age and glycemic strata. Conclusions Our findings indicate that advanced glycation end-products measured as skin autofluorescence might be involved in vascular stiffening independent of age and other cardiometabolic risk factors not only in individuals with diabetes but also in normoglycemic and prediabetic conditions. Skin autofluorescence might prove as a rapid and non-invasive method for assessment of macrovascular disease progression across all glycemic strata.}, language = {en} } @article{BlumeSchneiderGuentner2021, author = {Blume, Theresa and Schneider, Lisa and G{\"u}ntner, Andreas}, title = {Comparative analysis of throughfall observations in six different forest stands}, series = {Hydrological processes}, volume = {36}, journal = {Hydrological processes}, number = {3}, publisher = {Wiley}, address = {Hoboken}, issn = {0885-6087}, doi = {10.1002/hyp.14461}, pages = {21}, year = {2021}, abstract = {Throughfall, that is, the fraction of rainfall that passes through the forest canopy, is strongly influenced by rainfall and forest stand characteristics which are in turn both subject to seasonal dynamics. Disentangling the complex interplay of these controls is challenging, and only possible with long-term monitoring and a large number of throughfall events measured in parallel at different forest stands. We therefore based our analysis on 346 rainfall events across six different forest stands at the long-term terrestrial environmental observatory TERENO Northeast Germany. These forest stands included pure stands of beech, pine and young pine, and mixed stands of oak-beech, pine-beech and pine-oak-beech. Throughfall was overall relatively low, with 54-68\% of incident rainfall in summer. Based on the large number of events it was possible to not only investigate mean or cumulative throughfall but also its statistical distribution. The distributions of throughfall fractions show distinct differences between the three types of forest stands (deciduous, mixed and pine). The distributions of the deciduous stands have a pronounced peak at low throughfall fractions and a secondary peak at high fractions in summer, as well as a pronounced peak at higher throughfall fractions in winter. Interestingly, the mixed stands behave like deciduous stands in summer and like pine stands in winter: their summer distributions are similar to the deciduous stands but the winter peak at high throughfall fractions is much less pronounced. The seasonal comparison further revealed that the wooden components and the leaves behaved differently in their throughfall response to incident rainfall, especially at higher rainfall intensities. These results are of interest for estimating forest water budgets and in the context of hydrological and land surface modelling where poor simulation of throughfall would adversely impact estimates of evaporative recycling and water availability for vegetation and runoff.}, language = {en} } @article{FedchenkoTarkhanov2015, author = {Fedchenko, Dmitri and Tarkhanov, Nikolai Nikolaevich}, title = {An index formula for Toeplitz operators}, series = {Complex variables and elliptic equations}, volume = {60}, journal = {Complex variables and elliptic equations}, number = {12}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {1747-6933}, doi = {10.1080/17476933.2015.1050007}, pages = {1764 -- 1787}, year = {2015}, abstract = {We prove a Fedosov index formula for the index of Toeplitz operators connected with the Hardy space of solutions to an elliptic system of first-order partial differential equations in a bounded domain in R-n with smooth boundary.}, language = {en} } @article{MeraTarkhanov2022, author = {Mera, Azal Jaafar Musa and Tarkhanov, Nikolai}, title = {An elliptic equation of finite index in a domain}, series = {Boletin de la Sociedad Matem{\´a}tica Mexicana}, volume = {28}, journal = {Boletin de la Sociedad Matem{\´a}tica Mexicana}, number = {2}, publisher = {Springer International}, address = {New York [u.a.]}, issn = {1405-213X}, doi = {10.1007/s40590-022-00442-7}, pages = {10}, year = {2022}, abstract = {We give an example of first order elliptic equation for a complex-valued function in a plane domain which has a finite number of linearly independent solutions for any right-hand side. No boundary value conditions are thus required.}, language = {en} } @article{MickelssonPaycha2010, author = {Mickelsson, Jouko and Paycha, Sylvie}, title = {The logarithmic residue density of a generalized Laplacian}, series = {Journal of the Australian Mathematical Society}, volume = {90}, journal = {Journal of the Australian Mathematical Society}, number = {1}, publisher = {Cambridge Univ. Press}, address = {Cambridge}, issn = {0263-6115}, doi = {10.1017/S144678871100108X}, pages = {53 -- 80}, year = {2010}, abstract = {We show that the residue density of the logarithm of a generalized Laplacian on a closed manifold definesan invariant polynomial-valued differential form. We express it in terms of a finite sum of residues ofclassical pseudodifferential symbols. In the case of the square of a Dirac operator, these formulas providea pedestrian proof of the Atiyah-Singer formula for a pure Dirac operator in four dimensions and for atwisted Dirac operator on a flat space of any dimension. These correspond to special cases of a moregeneral formula by Scott and Zagier. In our approach, which is of perturbative nature, we use either aCampbell-Hausdorff formula derived by Okikiolu or a noncommutative Taylor-type formula.}, language = {en} } @article{Tarkhanov2016, author = {Tarkhanov, Nikolai Nikolaevich}, title = {Deformation quantization and boundary value problems}, series = {International journal of geometric methods in modern physics : differential geometery, algebraic geometery, global analysis \& topology}, volume = {13}, journal = {International journal of geometric methods in modern physics : differential geometery, algebraic geometery, global analysis \& topology}, publisher = {World Scientific}, address = {Singapore}, issn = {0219-8878}, doi = {10.1142/S0219887816500079}, pages = {176 -- 195}, year = {2016}, abstract = {We describe a natural construction of deformation quantization on a compact symplectic manifold with boundary. On the algebra of quantum observables a trace functional is defined which as usual annihilates the commutators. This gives rise to an index as the trace of the unity element. We formulate the index theorem as a conjecture and examine it by the classical harmonic oscillator.}, language = {en} }