@article{DengZouWangetal.2019,
  author    = {Deng, Zijun and Zou, Jie and Wang, Weiwei and Nie, Yan and Tung, Wing-Tai and Ma, Nan and Lendlein, Andreas},
  title     = {Dedifferentiation of mature adipocytes with periodic exposure to cold},
  series = {Clinical hemorheology and microcirculation : blood flow and vessels},
  volume    = {71},
  journal   = {Clinical hemorheology and microcirculation : blood flow and vessels},
  number    = {4},
  publisher = {IOS Press},
  address   = {Amsterdam},
  issn      = {1386-0291},
  doi       = {10.3233/CH-199005},
  pages     = {415 -- 424},
  year      = {2019},
  abstract  = {Lipid-containing adipocytes can dedifferentiate into fibroblast-like cells under appropriate culture conditions, which are known as dedifferentiated fat (DFAT) cells. However, the relative low dedifferentiation efficiency with the established protocols limit their widespread applications. In this study, we found that adipocyte dedifferentiation could be promoted via periodic exposure to cold (10 degrees C) in vitro. The lipid droplets in mature adipocytes were reduced by culturing the cells in periodic cooling/heating cycles (10-37 degrees C) for one week. The periodic temperature change led to the down-regulation of the adipogenic genes (FABP4, Leptin) and up-regulation of the mitochondrial uncoupling related genes (UCP1, PGC-1 alpha, and PRDM16). In addition, the enhanced expression of the cell proliferation marker Ki67 was observed in the dedifferentiated fibroblast-like cells after periodic exposure to cold, as compared to the cells cultured in 37 degrees C. Our in vitro model provides a simple and effective approach to promote lipolysis and can be used to improve the dedifferentiation efficiency of adipocytes towards multipotent DFAT cells.},
  language  = {en}
}
@misc{FriedrichFaivreBaeurleLenhardetal.2018,
  author    = {Friedrich, Thomas and Faivre, Lea and B{\"a}urle-Lenhard, Isabel and Schubert, Daniel},
  title     = {Chromatin-based mechanisms of temperature memory in plants},
  series = {Plant, cell \& environment : cell physiology, whole-plant physiology, community physiology},
  volume    = {42},
  journal   = {Plant, cell \& environment : cell physiology, whole-plant physiology, community physiology},
  number    = {3},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {0140-7791},
  doi       = {10.1111/pce.13373},
  pages     = {762 -- 770},
  year      = {2018},
  abstract  = {For successful growth and development, plants constantly have to gauge their environment. Plants are capable to monitor their current environmental conditions, and they are also able to integrate environmental conditions over time and store the information induced by the cues. In a developmental context, such an environmental memory is used to align developmental transitions with favourable environmental conditions. One temperature-related example of this is the transition to flowering after experiencing winter conditions, that is, vernalization. In the context of adaptation to stress, such an environmental memory is used to improve stress adaptation even when the stress cues are intermittent. A somatic stress memory has now been described for various stresses, including extreme temperatures, drought, and pathogen infection. At the molecular level, such a memory of the environment is often mediated by epigenetic and chromatin modifications. Histone modifications in particular play an important role. In this review, we will discuss and compare different types of temperature memory and the histone modifications, as well as the reader, writer, and eraser proteins involved.},
  language  = {en}
}
@article{JohnOlasMuellerRoeber2021,
  author    = {John, Sheeba and Olas, Justyna Jadwiga and M{\"u}ller-R{\"o}ber, Bernd},
  title     = {Regulation of alternative splicing in response to temperature variation in plants},
  series = {Journal of experimental botany},
  volume    = {72},
  journal   = {Journal of experimental botany},
  number    = {18},
  publisher = {Oxford Univ. Press},
  address   = {Oxford},
  issn      = {0022-0957},
  doi       = {10.1093/jxb/erab232},
  pages     = {6150 -- 6163},
  year      = {2021},
  abstract  = {Plants have evolved numerous molecular strategies to cope with perturbations in environmental temperature, and to adjust growth and physiology to limit the negative effects of extreme temperature. One of the strategies involves alternative splicing of primary transcripts to encode alternative protein products or transcript variants destined for degradation by nonsense-mediated decay. Here, we review how changes in environmental temperature-cold, heat, and moderate alterations in temperature-affect alternative splicing in plants, including crops. We present examples of the mode of action of various temperature-induced splice variants and discuss how these alternative splicing events enable favourable plant responses to altered temperatures. Finally, we point out unanswered questions that should be addressed to fully utilize the endogenous mechanisms in plants to adjust their growth to environmental temperature. We also indicate how this knowledge might be used to enhance crop productivity in the future.},
  language  = {en}
}