@article{Kummer2010,
  author    = {Kummer, Volker},
  title     = {Zusammenstellung lokaler Pilzliteratur 2004 - 2008},
  issn      = {0232-4598},
  year      = {2010},
  language  = {de}
}
@article{SchefflerHiller2010,
  author    = {Scheffler, Ingo and Hiller, Andre},
  title     = {Zur Ektoparasitenfauna der Flederm{\"a}use in Niedersachsen : Neue Funde am Iberg bei Bad Grund},
  year      = {2010},
  abstract  = {Bei einer aktuellen Studie am Iberg in Bad Grund konnten im September 2010 acht Fledermausarten parasitologisch untersucht werden. Die Faenge ergaben Nachweise von 11 Ektoparasitenarten (Fledermausfliegen, Floehe, Flughaut- und Ohrmilben), wobei einige davon Erstfunde fuer Niedersachsen sind. Aus den Fundangaben wurden Parasitenspektren fuer die einzelnen Wirtsarten erstellt und durch weitere unveroeffentlichte Meldungen ergaenzt. Fuer den Vergleich von Ektoparasitenspektren verschiedener Wirtsarten erfolgte die Einfuehrung einer Formel, die die Berechnung einer allgemeinen "Parasitenlast" ermoeglicht. Die Betrachtung der Verteilung von Ektoparasiten auf Individuen zeigte eine starke Trennung verschiedener Parasitengruppen, ein synchrones Vorkommen wurde nur selten registriert. Moeglicherweise ist die Konkurrenz zwischen Ektoparasitenarten ein bisher unterschaetzter determinierender Faktor fuer die Praesenz auf einem Wirt.},
  language  = {de}
}
@article{AppelhagenHuepLuetal.2010,
  author    = {Appelhagen, Ingo and Huep, Gunnar and Lu, Gui-Hua and Strompen, Georg and Weisshaar, Bernd and Sagasser, Martin},
  title     = {Weird fingers : functional analysis of WIP domain proteins},
  issn      = {0014-5793},
  doi       = {10.1016/j.febslet.2010.06.007},
  year      = {2010},
  abstract  = {WIP proteins form a plant specific subfamily of C2H2 zinc finger (ZF) proteins. In this study, we functionally characterized the WIP domain, which consists of four ZF motifs, and discuss molecular functions for WIP proteins. Mutations in each of the ZFs lead to loss of function of the TT1/WIP1 protein in Arabiopsis thaliana. SV40 type nuclear localisation signals were detected in two of the ZFs and functionally characterized using GFP fusions as well as new mutant alleles identified by TILLING. Promoter swap experiments showed that selected WIP proteins are partially able to take over TT1 function. Activity of the AtBAN promoter, a potential TT1 target, could be increased by the addition of TT1 to the TT2-TT8-TTG1 regulatory complex.},
  language  = {en}
}
@article{WronskiWacherHammondetal.2010,
  author    = {Wronski, Torsten and Wacher, Timothy and Hammond, Robert L. and Winney, Bruce and Hundertmark, Kris J. and Blacket, Mark J. and Mohammed, Osama B. and Flores, Benito and Omer, Sawsan A. and Macasero, William and Plath, Martin and Tiedemann, Ralph and Bleidorn, Christoph},
  title     = {Two reciprocally monophyletic mtDNA lineages elucidate the taxonomic status of Mountain gazelles (Gazella gazella)},
  issn      = {1477-2000},
  doi       = {10.1080/14772001003613192},
  year      = {2010},
  abstract  = {Mountain gazelles (Gazella gazella) rank among the most critically endangered mammals on the Arabian Peninsula. Past conservation efforts have been plagued by confusion about the phylogenetic relationship among various 'phenotypically discernable' populations, and even the question of species boundaries was far from being certain. This lack of knowledge has had a direct impact on conservation measures, especially ex situ breeding programmes, hampering the assignment of captive stocks to potential conservation units. Here, we provide a phylogenetic framework, based on the analysis of mtDNA sequences (360 bp cytochrome b and 213 bp Control Region) of 126 individuals collected from the wild throughout the Arabian Peninsula and from captive stocks. Our analyses revealed two reciprocally monophyletic genetic lineages within the presumed species Gazella gazella: one 'northern clade' on the Golan Heights (Israel/Syrian border) and one genetically diverse larger clade from the rest of the Arabian Peninsula including the Arava Valley (Negev, Israel). Applying the Strict Phylogenetic Species Concept (sensu Mishler \& Theriot, 2000) allows assigning species status to these two major clades.},
  language  = {en}
}
@article{VallerianiIgnatovaNagaretal.2010,
  author    = {Valleriani, Angelo and Ignatova, Zoya and Nagar, Apoorva and Lipowsky, Reinhard},
  title     = {Turnover of messenger RNA : polysome statistics beyond the steady state},
  issn      = {0295-5075},
  doi       = {10.1209/0295-5075/89/58003},
  year      = {2010},
  abstract  = {The interplay between turnover or degradation and ribosome loading of messenger RNA (mRNA) is studied theoretically using a stochastic model that is motivated by recent experimental results. Random mRNA degradation affects the statistics of polysomes, i.e., the statistics of the number of ribosomes per mRNA as extracted from cells. Since ribosome loading of newly created mRNA chains requires some time to reach steady state, a fraction of the extracted mRNA/ ribosome complexes does not represent steady state conditions. As a consequence, the mean ribosome density obtained from the extracted complexes is found to be inversely proportional to the mRNA length. On the other hand, the ribosome density profile shows an exponential decrease along the mRNA for prokaryotes and becomes uniform in eukaryotic cells. Copyright (C) EPLA, 2010},
  language  = {en}
}
@article{LehmannSchefflerHermanussen2010,
  author    = {Lehmann, Andreas and Scheffler, Christiane and Hermanussen, Michael},
  title     = {The variation in age at menarche : an indicator of historic developmental tempo},
  issn      = {0003-5548},
  doi       = {10.1127/0003-5548/2010/0086},
  year      = {2010},
  abstract  = {Ample literature describes the history of the association between the advances in the health and wealth of people, and mortality rates, life expectancy and adult height. Twentynine German studies with n > 200 subjects published since 1848 on menarcheal age, were reanalyzed, and 101 studies from various other European and non-European countries. On average, mean age at menarche declined since the mid-19(th) century. Historic urban samples tended to decline earlier than rural groups, upper class women earlier than working class women. In Germany, minimum values for the age at menarche were seen already between the two World Wars (Leipzig 12.6 years in 1934, Halle 13.3 years in 1939). Values for mean age and SD for age at menarche were strongly associated. With improving historic circumstances, the two parameters declined in parallel. The standard deviation for menarcheal age dropped from over 2.5 years in mid-19th century France to little more or even less than 1 year in most modern countries. In the German studies the correlation between menarcheal age and SD was almost complete with r = 0.96 (y = 0.35x - 3.53). Similar associations between mean age at menarche and SD for age were found in other European countries. The obvious and immediate effects of historic events on menarcheal age, and particularly on the age distribution, indicate that menarche is a sensitive indicator of public health and wealth, and may be an appropriate estimator for the socio-economic background of historic populations.},
  language  = {en}
}
@article{TschoepeTielboerger2010,
  author    = {Tsch{\"o}pe, Okka and Tielb{\"o}rger, Katja},
  title     = {The role of successional stage and small-scale disturbance for establishment of pioneer grass Corynephorus canescens},
  issn      = {1402-2001},
  doi       = {10.1111/j.1654-109X.2009.01072.x},
  year      = {2010},
  abstract  = {Question Which mechanisms promote the maintenance of the protected pioneer grass Corynephorus canescens in a mosaic landscape? Which are the interactive effects of small-scale disturbances, successional stage and year-to-year variation on early establishment probabilities of C. canescens? Location Brandenburg, NE Germany. Methods We measured emergence and survival rates over 3 yr in a sowing-experiment conducted in three successional stages (C. canescens- dominated site, ruderal forb site and pioneer forest) under two different regimes of mechanical ground disturbance (disturbed versus undisturbed control). Results Overall, disturbance led to higher emergence in a humid year and to lower emergence in a very dry year. Apparently, when soil moisture was sufficient, the main factor limiting C. canescens' establishment was competition, while in the dry year, water became the limiting factor. Survival rates were not affected by disturbance. In humid years, C. canescens emerged in higher numbers in open successional stages while in the dry year, emergence rates were higher in late stages, suggesting an important role of late successional stages for the persistence of C. canescens. Conclusions Our results suggest that small-scale disturbances can promote germination of C. canescens. However, disturbances should be carefully planned. The optimal strategy for promoting C. canescens is to apply disturbances just before seed dispersal and not during dry years. At the landscape scale, a mosaic of different vegetation types is beneficial for the protected pioneer grass as facilitation by late-successional species may be an important mechanism for the persistence of C. canescens, especially in dry years.},
  language  = {en}
}
@article{VerlindenVleugelsMarchaletal.2010,
  author    = {Verlinden, Heleen and Vleugels, Rut and Marchal, Elisabeth and Badisco, Liesbeth and Pfl{\"u}ger, Hans-Joachim and Blenau, Wolfgang and Vanden Broeck, Jozef},
  title     = {The role of octopamine in locusts and other arthropods},
  issn      = {0022-1910},
  doi       = {10.1016/j.jinsphys.2010.05.018},
  year      = {2010},
  abstract  = {The biogenic amine octopamine and its biological precursor tyramine are thought to be the invertebrate functional homologues of the vertebrate adrenergic transmitters. Octopamine functions as a neuromodulator, neurotransmitter and neurohormone in insect nervous systems and prompts the whole organism to "dynamic action". A growing number of studies suggest a prominent role for octopamine in modulating multiple physiological and behavioural processes in invertebrates, as for example the phase transition in Schistocerca gregaria. Both octopamine and tyramine exert their effects by binding to specific receptor proteins that belong to the superfamily of G protein-coupled receptors. Since these receptors do not appear to be present in vertebrates, they may present very suitable and specific insecticide and acaricide targets. (C) 2010 Elsevier Ltd. All rights reserved.},
  language  = {en}
}
@article{HempHellerKehletal.2010,
  author    = {Hemp, Claudia and Heller, Klaus-Gerhard and Kehl, Siegfried and Warchalowska-Sliwa, Elzbieta and Waegele, Johann Wolfgang and Hemp, Andreas},
  title     = {The Phlesirtes complex (Orthoptera, Tettigoniidae, Conocephalinae, Conocephalini) reviewed : integrating morphological, molecular, chromosomal and bioacoustic data},
  issn      = {0307-6970},
  doi       = {10.1111/j.1365-3113.2009.00512.x},
  year      = {2010},
  abstract  = {The tettigoniid genus Phlesirtes Bolivar and its allies are reviewed. Morphological, ecological and molecular data prompt the erection of the new genus Chortoscirtes gen.n. with type species Xiphidion meruense Sjostedt. The genera Phlesirtes, Chortoscirtes, Karniella and Naskreckiella are characterized by morphological characters supported by molecular, acoustic, ecological and chromosomal data. Four species, Chortoscirtes pseudomeruensis sp.n., C. masaicus sp.n., C. puguensis sp.n. and C. serengeti sp.n., are described from localities in northern and coastal Tanzania and one Karniella, K. crassicerca sp.n., is described from Uganda. The following comb n. are proposed: Phlesirtes kibonotensis (Sjostedt) and Phlesirtes kilimandjaricus (Sjostedt). Subtribal status is proposed for the four investigated African genera. A key to the Chortoscirtes species is provided.},
  language  = {en}
}
@article{HejaziFettkeKoettingetal.2010,
  author    = {Hejazi, Mahdi and Fettke, J{\"o}rg and Koetting, Oliver and Zeeman, Samuel C. and Steup, Martin},
  title     = {The Laforin-like dual-specificity phosphatase SEX4 from Arabidopsis hydrolyzes both C6-and C3-phosphate esters introduced by starch-related dikinases and thereby affects phase transition of alpha-glucans},
  issn      = {0032-0889},
  doi       = {10.1104/pp.109.149914},
  year      = {2010},
  abstract  = {The biochemical function of the Laforin-like dual-specific phosphatase AtSEX4 (EC 3.1.3.48) has been studied. Crystalline maltodextrins representing the A- or the B-type allomorph were prephosphorylated using recombinant glucan, water dikinase (StGWD) or the successive action of both plastidial dikinases (StGWD and AtPWD). AtSEX4 hydrolyzed carbon 6-phosphate esters from both the prephosphorylated A- and B-type allomorphs and the kinetic constants are similar. The phosphatase also acted on prelabeled carbon-3 esters from both crystalline maltodextrins. Similarly, native starch granules prelabeled in either the carbon-6 or carbon-3 position were also dephosphorylated by AtSEX4. The phosphatase did also hydrolyze phosphate esters of both prephosphorylated maltodextrins when the (phospho)glucans had been solubilized by heat treatment. Submillimolar concentrations of nonphosphorylated maltodextrins inhibited AtSEX4 provided they possessed a minimum of length and had been solubilized. As opposed to the soluble phosphomaltodextrins, the AtSEX4- mediated dephosphorylation of the insoluble substrates was incomplete and at least 50\% of the phosphate esters were retained in the pelletable (phospho) glucans. The partial dephosphorylation of the insoluble glucans also strongly reduced the release of nonphosphorylated chains into solution. Presumably, this effect reflects fast structural changes that following dephosphorylation occur near the surface of the maltodextrin particles. A model is proposed defining distinct stages within the phosphorylation/dephosphorylation-dependent transition of alpha-glucans from the insoluble to the soluble state.},
  language  = {en}
}
@article{DoorduinvandenHofVrielingetal.2010,
  author    = {Doorduin, Leonie J. and van den Hof, Kevin and Vrieling, Klaas and Joshi, Jasmin Radha},
  title     = {The lack of genetic bottleneck in invasive Tansy ragwort populations suggests multiple source populations},
  issn      = {1439-1791},
  doi       = {10.1016/j.baae.2009.12.007},
  year      = {2010},
  abstract  = {Jacobaea vulgaris (Asteraceae) is a species of Eurasian origin that has become a serious non-indigenous weed in Australia, New Zealand, and North America. We used neutral molecular markers to (1) test for genetic bottlenecks in invasive populations and (2) to investigate the invasion pathways. It is for the first time that molecular markers were used to unravel the process of introduction in this species. The genetic variation of 15 native populations from Europe and 16 invasive populations from Australia, New Zealand and North America were compared using the amplified fragment length polymorphisms (AFLP's). An analysis of molecular variance showed that a significant part (10\%) of the total genetic variations between all individuals could be explained by native or invasive origin. Significant among-population differentiation was detected only in the native range, whereas populations from the invasive areas did not significantly differ from each other; nor did the Australian, New Zealand and North American regions differ within the invasive range. The result that native populations differed significantly from each other and that the amount of genetic variation, measured as the number of polymorphic bands, did not differ between the native and invasive area, strongly suggests that introductions from multiple source populations have occurred. The lack of differentiation between invasive regions suggests that either introductions may have occurred from the same native sources in all invasive regions or subsequent introductions took place from one into another invasive region and the same mix of genotypes was subsequently introduced into all invasive regions. An assignment test showed that European populations from Ireland, the Netherlands and the United Kingdom most resembled the invasive populations.},
  language  = {en}
}
@article{JingVershininGrzebytaetal.2010,
  author    = {Jing, Runchun and Vershinin, Alexander and Grzebyta, Jacek and Shaw, Paul and Sm{\"i}ykal, Petr and Marshall, David and Ambrose, Michael J. and Ellis, Noel and Flavell, Andrew J.},
  title     = {The genetic diversity and evolution of field pea (Pisum) studied by high throughput retrotransposon based insertion polymorphism (RBIP) marker analysis},
  issn      = {1471-2148},
  doi       = {10.1186/1471-2148-10-44},
  year      = {2010},
  language  = {en}
}
@article{VerlindenVleugelsMarchaletal.2010,
  author    = {Verlinden, Heleen and Vleugels, Rut and Marchal, Elisabeth and Badisco, Liesbeth and Tobback, Julie and Pfl{\"u}ger, Hans-Joachim and Blenau, Wolfgang and Vanden Broeck, Jozef},
  title     = {The cloning, phylogenetic relationship and distribution pattern of two new putative GPCR-type octopamine receptors in the desert locust (Schistocerca gregaria)},
  issn      = {0022-1910},
  doi       = {10.1016/j.jinsphys.2010.03.003},
  year      = {2010},
  abstract  = {The biogenic amine octopamine functions as a neuromodulator, neurotransmitter and neurohormone in insect nervous systems. It plays a prominent role in modulating multiple physiological and behavioural processes in invertebrates. Octopamine exerts its effects by binding to specific receptor proteins that belong to the superfamily of G protein-coupled receptors. We found two partial sequences of putative octopamine receptors in the desert locust Schistocerca gregaria (SgOct alpha R and SgOct beta R) and investigated their transcript levels in males and females of both phases and during the transition between long-term solitarious and gregarious locusts. The transcript levels of SgOctaR are the highest in the central nervous system, whereas those of SgOct beta R are the highest in the flight muscles, followed by the central nervous system. Both SgOct alpha R and SgOct beta R show higher transcript levels in long-term gregarious locusts as compared to solitarious ones. The rise of SgOct beta R transcript levels already appears during the first 4 h of gregarisation, during which also the behavioural changes take place.},
  language  = {en}
}
@article{AndresHankeBaxaetal.2010,
  author    = {Andres, Dorothee and Hanke, Christin and Baxa, Ulrich and Seul, Anait and Barbirz, Stefanie and Seckler, Robert},
  title     = {Tailspike interactions with lipopolysaccharide effect DNA ejection from phage P22 particles in vitro},
  issn      = {0021-9258},
  doi       = {10.1074/jbc.M110.169003},
  year      = {2010},
  abstract  = {Initial attachment of bacteriophage P22 to the Salmonella host cell is known to be mediated by interactions between lipopolysaccharide (LPS) and the phage tailspike proteins (TSP), but the events that subsequently lead to DNA injection into the bacterium are unknown. We used the binding of a fluorescent dye and DNA accessibility to DNase and restriction enzymes to analyze DNA ejection from phage particles in vitro. Ejection was specifically triggered by aggregates of purified Salmonella LPS but not by LPS with different O-antigen structure, by lipid A, phospholipids, or soluble O-antigen polysaccharide. This suggests that P22 does not use a secondary receptor at the bacterial outer membrane surface. Using phage particles reconstituted with purified mutant TSP in vitro, we found that the endorhamnosidase activity of TSP degrading the O-antigen polysaccharide was required prior to DNA ejection in vitro and DNA replication in vivo. If, however, LPS was pre-digested with soluble TSP, it was no longer able to trigger DNA ejection, even though it still contained five O-antigen oligosaccharide repeats. Together with known data on the structure of LPS and phage P22, our results suggest a molecular model. In this model, tail-spikes position the phage particles on the outer membrane surface for DNA ejection. They force gp26, the central needle and plug protein of the phage tail machine, through the core oligosaccharide layer and into the hydrophobic portion of the outer membrane, leading to refolding of the gp26 lazo-domain, release of the plug, and ejection of DNA and pilot proteins.},
  language  = {en}
}
@article{StaabWalossekNellessenetal.2010,
  author    = {Staab, Paul R. and Walossek, J{\"o}rg and Nellessen, David and Gr{\"u}nberg, Raik and Arndt, Katja Maren and M{\"u}ller, Kristian M.},
  title     = {SynBioWave : a real-time communication platform for molecular and synthetic biology},
  issn      = {1367-4803},
  doi       = {10.1093/bioinformatics/btq518},
  year      = {2010},
  abstract  = {Synthetic Biology is advanced by many users and relies on the assembly of genetic elements to devices, systems and finally genomes. SynBioWave is a software suite that enables multiple distributed users to analyze and construct genetic parts in real-time collaboration. It builds on Google Wave and provides an extensible robot-robot-user communication framework, a menu driven user interface, biological data handling including DAS and an internal database communication. We demonstrate its use by implementing robots for gene-data retrieval, manipulation and display. The initial development of SynBioWave demonstrates the power of the underlying Google Wave protocol for Synthetic Biology and lays the foundation for continuous and user-friendly extensions. Specialized wave-robots with a manageable set of capabilities will divide and conquer the complex task of creating a genome in silico.},
  language  = {en}
}
@article{GriessnerHartigChristmannetal.2010,
  author    = {Grießner, Matthias and Hartig, Dave and Christmann, Alexander and Ehrentreich-F{\"o}rster, Eva and Warsinke, Axel and Bier, Frank Fabian},
  title     = {Surface regeneration of microfluidic microarray printheads through plasma techniques},
  issn      = {0960-1317},
  doi       = {10.1088/0960-1317/20/3/037002},
  year      = {2010},
  abstract  = {This work describes a method for surface regeneration of microfluidic microarray printheads through plasma techniques. Modification procedures were chosen in a way to obtain high reproducibility with a minimum of time consumption. The idea behind this is a complete regeneration of a microarray printhead before or after usage to achieve best printing results over a typical print job. A sequence of low-pressure oxygen-plasma and plasma polymerization with hexamethyldisiloxane (HMDSO) was used to regenerate printheads. Proof of the concept is given through quality control performed with a spotter implemented CCD camera, contact angle measurements and a typical hybridization experiment. Stable printing results were obtained over 3000 activations showing that the presented method is suitable for treatment of microarray printheads.},
  language  = {en}
}
@article{SpricigoRichterLeimkuehleretal.2010,
  author    = {Spricigo, Roberto and Richter, Claudia and Leimk{\"u}hler, Silke and Gorton, Lo and Scheller, Frieder W. and Wollenberger, Ursula},
  title     = {Sulfite biosensor based on osmium redox polymer wired sulfite oxidase},
  issn      = {0927-7757},
  doi       = {10.1016/j.colsurfa.2009.09.001},
  year      = {2010},
  abstract  = {A biosensor, based on a redoxactive osmium polymer and sulfite oxidase on screen-printed electrodes, is presented here as a promising method for the detection of sulfite. A catalytic oxidative current was generated when a sample containing sulfite was pumped over the carbon screen-printed electrode modified with osmium redox polymer wired sulfite oxidase. A stationary value was reached after approximately 50 s and a complete measurement lasted no more than 3 min. The electrode polarized at -0.1 V (vs. Ag vertical bar AgCl 1M KCl) permits minimizing the influence of interfering substances, since these compounds can be unspecific oxidized at higher potentials. Because of the good stability of the protein film on the electrode surface, a well functioning biosensor-flow system was possible to construct. The working stability and reproducibility were further enhanced by the addition of bovine serum albumin generating a more long-term stable and biocompatible protein environment. The optimized biosensor showed a stable signal for more than a week of operation and a coefficient of variation of 4.8\% for 12 successive measurements. The lower limit of detection of the sensor was 0.5 mu M sulfite and the response was linear until 100 mu M. The high sensitivity permitted a 1:500 dilution of wine samples. The immobilization procedure and the operational conditions granted minimized interferences. Additionally, repeating the immobilization procedure to form several layers of wired SO further increased the sensitivity of such a sensor. Finally. the applicability of the developed sulfite biosensor was tested on real samples, such as white and red wines.},
  language  = {en}
}
@article{TimmerTheissJuerchottetal.2010,
  author    = {Timmer, Marco and Theiss, Hans and J{\"u}rchott, Katrin and Ries, Christian and Paron, Igor and Franz, W. and Selbig, Joachim and Guo, Ketai and Tonn, J{\"o}rg and Schichor, Christian},
  title     = {Stromal-Derived Factor 1a (Sdf-1a), a Homing Factor for Mesenchymal Progenitor Cells, Is Elevated in Tumor Tissue and Plasma of Glioma Patients},
  issn      = {1522-8517},
  year      = {2010},
  abstract  = {Malignant gliomas are a fatal disease lacking sufficient possibilities for early diagnosis and chemical markers to detect remission or relapse. The recruitment of progenitor cells such as mesenchymal stem cells (MSC) is a main feature of gliomas. Stromal cell-derived factor-1 (SDF-1), a chemokine produced in glioma cell lines, enhances migration in MSC and has been associated with cell survival and apoptosis in gliomas. Therefore, this study was performed to evaluate (i) whether SDF-1 and its receptors are expressed in human malignant gliomas in situ and (ii) if SDF-1 might potentially play a role in recruiting MSCs into human glioma. In glioblastoma tissue, immunohistochemistry revealed that SDF-1 and its receptor CXCR4 are expressed in regions of angiogenesis and necrosis, and qPCR showed that SDF-1 is elevated. Public expression data indicated that CXCR4 was upregulated. The latter data also illustrate that SDF-1 could be up- or downregulated in glioma compared to normal brain in a transcript-specific manner. In plasma, SDF-1 is elevated in glioma patients. The level is reduced by both dexamethasone intake and surgery. Dexamethasone also decreased SDF-1 production in cells in vitro. The undirected migration of human MSC (hMSC) was not enhanced by the addition of SDF-1. However, SDF-1 stimulated directed invasion of hMSC in a dose-dependent manner. Taken together, we show that SDF-1 is a potent chemoattractant of progenitor cells such as hMSCs and that its expression is elevated in glioma tissue, which results in elevated SDF-1 levels in the patient's plasma samples with concomittant decrease after tumor resection. The fact that elevated SDF-1 plasma levels are significantly decreased after tumor surgery could be a first hint that SDF-1 might act as tumor marker for malignant gliomas in order to detect disease progression or remission, respectively.},
  language  = {en}
}
@article{AbrahamGruss2010,
  author    = {Abraham, Andreas and Gruss, Michael},
  title     = {Stress inoculation facilitates active avoidance learning of the semi-precocial rodent Octodon degus},
  issn      = {0166-4328},
  doi       = {10.1016/j.bbr.2010.05.018},
  year      = {2010},
  abstract  = {A growing body of evidence highlights the impact of the early social environment for the adequate development of brain and behavior in animals and humans. Disturbances of this environment were found to be both maladaptive and adaptive to emotional and cognitive function. Using the semi-precocial, biparental rodent Octodon degus, we aimed to examine (i) the impact of age (juvenile/adult), sex (male/female), and (ii) "motivation" to solve the task (by applying increasing foot-shock-intensities) on two-way active avoidance (TWA) learning in socially reared degus, and (iii) whether early life stress inoculation by 1 h daily parental separation during the first three weeks of life has maladaptive or adaptive consequences on cognitive function as measured by TWA learning. Our results showed that (i) juvenile degus, unlike altricial rats of the same age, can successfully learn the TWA task comparable to adults, and (ii) that learning performance improves with increasing "task motivation", irrespective of age and sex. Furthermore, we revealed that (iii) stress inoculation improves avoidance learning, particularly in juvenile males, quantitatively and qualitatively depending on "task motivation". In conclusion, the present study describes for the first time associative learning in O. degus and its modulation by early life stress experience as an animal model to study the underlying mechanisms of learning and memory in the stressed and unstressed brain. Although, stress is commonly viewed as being maladaptive, our data indicate that early life stress inoculation triggers developmental cascades of adaptive functioning, which may improve cognitive and emotional processing of stressors later in life.},
  language  = {en}
}
@article{SteinbergOuerghemmiHerrmannetal.2010,
  author    = {Steinberg, Christian E. W. and Ouerghemmi, Nadia and Herrmann, Steffen and Bouchnak, Rihab and Timofeyev, Maxim A. and Menzel, Ralph},
  title     = {Stress by poor food quality and exposure to humic substances : daphnia magna responds with oxidative stress, lifespan extension, but reduced offspring numbers},
  issn      = {0018-8158},
  doi       = {10.1007/s10750-010-0334-4},
  year      = {2010},
  abstract  = {In freshwater systems, many abiotic and biotic factors determine the natural fluctuation of Daphnia spec. populations: climatic and water quality parameters, quantitative and qualitative food quality and quantity, predation, and humic substances. Many factors/stressors act in concert. In this contribution, we supplied Daphnia magna with two different diets (chlorococcal alga Pseudokirchneriella subcapitata and baker's yeast) fed ad libitum and exposed it to an environmentally realistic concentration of humic substances (HSs). Exposure to HSs caused a transcriptionally controlled stress response with studied genes; cat and hsp60, for the latter partial sequences have been identified. Furthermore, the exposure to HSs reduced the antioxidant capacity. Yet, a much stronger oxidative stress is caused by feeding yeast, which reduced the anti-oxidative capacity to values of approximately 50\% of the green algal diet. This reduction is most likely due to the yeast's cell wall to resist digestion rather than to the elemental ratio or deficiency in long-chained unsaturated fatty acids, because both diets were deficient in fatty acids with back bones of more than 20 C-atoms. We assume that the biochemical machinery in the gut continuously activated oxygen to cleave the yeast's cell wall and, hence, reduced the antioxidative capacity of the animals. Neither the analyzed oxidant, H2O2, nor the antioxidants, total apparent ascorbic acid nor free proline, reflected the oxidative stress situations properly. In addition to the stress, HS exposure extended the mean lifespan of algae-fed D. magna, but at the expense of offspring numbers; so did also the pure yeast diet as compared to the algae diet. The first lifespan extension can be explained by the potential of HSs to block the pathway via the insulin-like growth factor 1 (IGF), whereas the second matches the, in aging papers, well described, but mechanistically poorly understood caloric restriction. Yeast-fed animals, exposed to HSs changed the energy allocation by reducing life span, but increasing offspring numbers. With the lifespan and offspring numbers, ecologically relevant parameters are differently affected by the simultaneous action of two environmentally relevant stressors.},
  language  = {en}
}