@misc{BaldKeller2014,
  author    = {Bald, Ilko and Keller, Adrian},
  title     = {Molecular processes studied at a single-molecule level using DNA origami nanostructures and atomic force microscopy},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {9},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-47584},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-475843},
  pages     = {13803 -- 13823},
  year      = {2014},
  abstract  = {DNA origami nanostructures allow for the arrangement of different functionalities such as proteins, specific DNA structures, nanoparticles, and various chemical modifications with unprecedented precision. The arranged functional entities can be visualized by atomic force microscopy (AFM) which enables the study of molecular processes at a single-molecular level. Examples comprise the investigation of chemical reactions, electron-induced bond breaking, enzymatic binding and cleavage events, and conformational transitions in DNA. In this paper, we provide an overview of the advances achieved in the field of single-molecule investigations by applying atomic force microscopy to functionalized DNA origami substrates.},
  language  = {en}
}
@misc{BaldKeller2014,
  author    = {Bald, Ilko and Keller, Adrian},
  title     = {Molecular processes studied at a single-molecule level using DNA origami nanostructures and atomic force microscopy},
  series = {Molecules},
  volume    = {19},
  journal   = {Molecules},
  number    = {9},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1420-3049},
  doi       = {10.3390/molecules190913803},
  pages     = {13803 -- 13823},
  year      = {2014},
  abstract  = {DNA origami nanostructures allow for the arrangement of different functionalities such as proteins, specific DNA structures, nanoparticles, and various chemical modifications with unprecedented precision. The arranged functional entities can be visualized by atomic force microscopy (AFM) which enables the study of molecular processes at a single-molecular level. Examples comprise the investigation of chemical reactions, electron-induced bond breaking, enzymatic binding and cleavage events, and conformational transitions in DNA. In this paper, we provide an overview of the advances achieved in the field of single-molecule investigations by applying atomic force microscopy to functionalized DNA origami substrates.},
  language  = {en}
}
@article{KellerRackwitzCauetetal.2014,
  author    = {Keller, Adrian and Rackwitz, Jenny and Cauet, Emilie and Lievin, Jacques and K{\"o}rzd{\"o}rfer, Thomas and Rotaru, Alexandru and Gothelf, Kurt V. and Besenbacher, Flemming and Bald, Ilko},
  title     = {Sequence dependence of electron-induced DNA strand breakage revealed by DNA nanoarrays},
  series = {Scientific reports},
  volume    = {4},
  journal   = {Scientific reports},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/srep07391},
  pages     = {6},
  year      = {2014},
  language  = {en}
}
@misc{BaldKopyraKeller2014,
  author    = {Bald, Ilko and Kopyra, Janina and Keller, Adrian},
  title     = {On the role of fluoro-substituted nucleosides in DNA radiosensitization for tumor radiation therapy},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-73412},
  pages     = {6825 -- 6829},
  year      = {2014},
  abstract  = {Gemcitabine (2′,2′-difluorocytidine) is a well-known radiosensitizer routinely applied in concomitant chemoradiotherapy. During irradiation of biological media with high-energy radiation secondary low-energy (<10 eV) electrons are produced that can directly induce chemical bond breakage in DNA by dissociative electron attachment (DEA). Here, we investigate and compare DEA to the three molecules 2′-deoxycytidine, 2′-deoxy-5-fluorocytidine, and gemcitabine. Fluorination at specific molecular sites, i.e., nucleobase or sugar moiety, is found to control electron attachment and subsequent dissociation pathways. The presence of two fluorine atoms at the sugar ring results in more efficient electron attachment to the sugar moiety and subsequent bond cleavage. For the formation of the dehydrogenated nucleobase anion, we obtain an enhancement factor of 2.8 upon fluorination of the sugar, whereas the enhancement factor is 5.5 when the nucleobase is fluorinated. The observed fragmentation reactions suggest enhanced DNA strand breakage induced by secondary electrons when gemcitabine is incorporated into DNA.},
  language  = {en}
}
@article{BaldKellerKopyra2014,
  author    = {Bald, Ilko and Keller, Adrian and Kopyra, Janina},
  title     = {On the role of fluoro-substituted nucleosides in DNA radiosensitization for tumor radiation therapy},
  series = {RSC Advances : an international journal to further the chemical sciences},
  volume    = {4},
  journal   = {RSC Advances : an international journal to further the chemical sciences},
  number    = {13},
  publisher = {Royal Society of Chemistry},
  issn      = {2046-2069},
  doi       = {10.1039/C3RA46735J},
  pages     = {6825 -- 6829},
  year      = {2014},
  abstract  = {Gemcitabine (2′,2′-difluorocytidine) is a well-known radiosensitizer routinely applied in concomitant chemoradiotherapy. During irradiation of biological media with high-energy radiation secondary low-energy (<10 eV) electrons are produced that can directly induce chemical bond breakage in DNA by dissociative electron attachment (DEA). Here, we investigate and compare DEA to the three molecules 2′-deoxycytidine, 2′-deoxy-5-fluorocytidine, and gemcitabine. Fluorination at specific molecular sites, i.e., nucleobase or sugar moiety, is found to control electron attachment and subsequent dissociation pathways. The presence of two fluorine atoms at the sugar ring results in more efficient electron attachment to the sugar moiety and subsequent bond cleavage. For the formation of the dehydrogenated nucleobase anion, we obtain an enhancement factor of 2.8 upon fluorination of the sugar, whereas the enhancement factor is 5.5 when the nucleobase is fluorinated. The observed fragmentation reactions suggest enhanced DNA strand breakage induced by secondary electrons when gemcitabine is incorporated into DNA.},
  language  = {en}
}