@article{PrieskeDalagerHerzetal.2019,
  author    = {Prieske, Olaf and Dalager, Tina and Herz, Michael and Hortobagyi, Tibor and Sjogaard, Gisela and Sogaard, Karen and Granacher, Urs},
  title     = {Effects of Physical Exercise Training in the Workplace on Physical Fitness: A Systematic Review and Meta-analysis},
  series = {Sports medicine},
  volume    = {49},
  journal   = {Sports medicine},
  number    = {12},
  publisher = {Springer},
  address   = {Northcote},
  issn      = {0112-1642},
  doi       = {10.1007/s40279-019-01179-6},
  pages     = {1903 -- 1921},
  year      = {2019},
  abstract  = {Background There is evidence that physical exercise training (PET) conducted at the workplace is effective in improving physical fitness and thus health. However, there is no current systematic review available that provides high-level evidence regarding the effects of PET on physical fitness in the workforce. Objectives To quantify sex-, age-, and occupation type-specific effects of PET on physical fitness and to characterize dose-response relationships of PET modalities that could maximize gains in physical fitness in the working population. Data Sources A computerized systematic literature search was conducted in the databases PubMed and Cochrane Library (2000-2019) to identify articles related to PET in workers. Study Eligibility Criteria Only randomized controlled trials with a passive control group were included if they investigated the effects of PET programs in workers and tested at least one fitness measure. Study Appraisal and Synthesis Methods Weighted mean standardised mean differences (SMDwm) were calculated using random effects models. A multivariate random effects meta-regression was computed to explain the influence of key training modalities (e.g., training frequency, session duration, intensity) on the effectiveness of PET on measures of physical fitness. Further, subgroup univariate analyses were computed for each training modality. Additionally, methodological quality of the included studies was rated with the help of the Physiotherapy Evidence Database (PEDro) Scale. Results Overall, 3423 workers aged 30-56 years participated in 17 studies (19 articles) that were eligible for inclusion. Methodological quality of the included studies was moderate with a median PEDro score of 6. Our analyses revealed significant, small-sized effects of PET on cardiorespiratory fitness (CRF), muscular endurance, and muscle power (0.29 <= SMDwm <= 0.48). Medium effects were found for CRF and muscular endurance in younger workers (<= 45 years) (SMDwm = 0.71) and white-collar workers (SMDwm = 0.60), respectively. Multivariate random effects meta-regression for CRF revealed that none of the examined training modalities predicted the effects of PET on CRF (R-2 = 0). Independently computed subgroup analyses showed significant PET effects on CRF when conducted for 9-12 weeks (SMDwm = 0.31) and for 17-20 weeks (SMDwm = 0.74). Conclusions PET effects on physical fitness in healthy workers are moderated by age (CRF) and occupation type (muscular endurance). Further, independently computed subgroup analyses indicated that the training period of the PET programs may play an important role in improving CRF in workers.},
  language  = {en}
}
@article{NegyesiHortobagyiHilletal.2022,
  author    = {Negyesi, Janos and Hortobagyi, Tibor and Hill, Jessica and Granacher, Urs and Nagatomi, Ryoichi},
  title     = {Can compression garments reduce the deleterious effects of physical exercise on muscle strength?},
  series = {Sports medicine},
  volume    = {52},
  journal   = {Sports medicine},
  number    = {9},
  publisher = {Springer},
  address   = {Northcote},
  issn      = {0112-1642},
  doi       = {10.1007/s40279-022-01681-4},
  pages     = {2159 -- 2175},
  year      = {2022},
  abstract  = {Background The use of compression garments (CGs) during or after training and competition has gained popularity in the last few decades. However, the data concerning CGs' beneficial effects on muscle strength-related outcomes after physical exercise remain inconclusive. Objective The aim was to determine whether wearing CGs during or after physical exercise would facilitate the recovery of muscle strength-related outcomes. Methods A systematic literature search was conducted across five databases (PubMed, SPORTDiscus, Web of Science, Scopus, and EBSCOhost). Data from 19 randomized controlled trials (RCTs) including 350 healthy participants were extracted and meta-analytically computed. Weighted between-study standardized mean differences (SMDs) with respect to their standard errors (SEs) were aggregated and corrected for sample size to compute overall SMDs. The type of physical exercise, the body area and timing of CG application, and the time interval between the end of the exercise and subsequent testing were assessed. Results CGs produced no strength-sparing effects (SMD [95\% confidence interval]) at the following time points (t) after physical exercise: immediately <= t < 24 h: - 0.02 (- 0.22 to 0.19), p = 0.87; 24 <= t < 48 h: - 0.00 (- 0.22 to 0.21), p = 0.98; 48 <= t < 72 h: - 0.03 (- 0.43 to 0.37), p = 0.87; 72 <= t < 96 h: 0.14 (- 0.21 to 0.49), p = 0.43; 96 h <= t: 0.26 (- 0.33 to 0.85), p = 0.38. The body area where the CG was applied had no strength-sparing effects. CGs revealed weak strength-sparing effects after plyometric exercise. Conclusion Meta-analytical evidence suggests that wearing a CG during or after training does not seem to facilitate the recovery of muscle strength following physical exercise. Practitioners, athletes, coaches, and trainers should reconsider the use of CG as a tool to reduce the effects of physical exercise on muscle strength.},
  language  = {en}
}
@article{MuehlbauerGranacherBordeetal.2017,
  author    = {Muehlbauer, Thomas and Granacher, Urs and Borde, Ron and Hortobagyi, Tibor},
  title     = {Non-Discriminant Relationships between Leg Muscle Strength, Mass and Gait Performance in Healthy Young and Old Adults},
  series = {Gerontology},
  volume    = {64},
  journal   = {Gerontology},
  number    = {1},
  publisher = {Karger},
  address   = {Basel},
  issn      = {0304-324X},
  doi       = {10.1159/000480150},
  pages     = {11 -- 18},
  year      = {2017},
  abstract  = {Background: Gait speed declines with increasing age, but it is unclear if gait speed preferentially correlates with leg muscle strength or mass. Objective: We determined the relationship between gait speed and (1) leg muscle strength measured at 3 lower extremity joints and (2) leg lean tissue mass (LTM) in healthy young (age: 25 years, n = 20) and old (age: 70 years, n = 20) adults. Methods: Subjects were tested for maximal isokinetic hip, knee, and ankle extension torque, leg LTM by bioimpedance, and gait performance (i.e., gait speed, stride length) at preferred and maximal gait speeds. Results: We found no evidence for a preferential relationship between gait performance and leg muscle strength compared with gait performance and leg LTM in healthy young and old adults. In old adults, hip extensor strength only predicted habitual gait speed (R-2 = 0.29, p = 0.015), whereas ankle plantarflexion strength only predicted maximal gait speed and stride length (both R-2 = 0.40, p = 0.003). Conclusions: Gait speed did not preferentially correlate with leg muscle strength or leg LTM, favoring neither outcome for predicting mobility. Thus, we recommend that both leg muscle strength and leg LTM should be tested and trained complementarily. Further, hip and ankle extension torque predicted gait performance, and thus we recommend to test and train healthy old adults by functional integrated multiarticular rather than monoarticular lower extremity strength exercises.},
  language  = {en}
}
@misc{LesinskiHortobagyiMuehlbaueretal.2016,
  author    = {Lesinski, Melanie and Hortobagyi, Tibor and M{\"u}hlbauer, Thomas and Gollhofer, Albert and Granacher, Urs},
  title     = {Effects of Balance Training on Balance Performance in Healthy Older Adults: A Systematic Review and Meta-analysis (vol 45, pg 1721, 2015)},
  series = {Sports medicine},
  volume    = {46},
  journal   = {Sports medicine},
  publisher = {Springer},
  address   = {Northcote},
  issn      = {0112-1642},
  doi       = {10.1007/s40279-016-0500-6},
  pages     = {457 -- 457},
  year      = {2016},
  language  = {en}
}
@misc{LesinskiHortobagyiMuehlbaueretal.2016,
  author    = {Lesinski, Melanie and Hortobagyi, Tibor and M{\"u}hlbauer, Thomas and Gollhofer, Albert and Granacher, Urs},
  title     = {Dose-Response Relationships of Balance Training in Healthy Young Adults: A Systematic Review and Meta-Analysis (vol 45, pg 557, 2015)},
  series = {Sports medicine},
  volume    = {46},
  journal   = {Sports medicine},
  publisher = {Springer},
  address   = {Northcote},
  issn      = {0112-1642},
  doi       = {10.1007/s40279-016-0499-8},
  pages     = {455 -- 455},
  year      = {2016},
  language  = {en}
}
@misc{LesinskiHortobagyiMuehlbaueretal.2015,
  author    = {Lesinski, Melanie and Hortobagyi, Tibor and M{\"u}hlbauer, Thomas and Gollhofer, Albert and Granacher, Urs},
  title     = {Dose-Response Relationships of Balance Training in Healthy Young Adults: A Systematic Review and Meta-Analysis},
  series = {Sports medicine},
  volume    = {45},
  journal   = {Sports medicine},
  number    = {4},
  publisher = {Springer},
  address   = {Northcote},
  issn      = {0112-1642},
  doi       = {10.1007/s40279-014-0284-5},
  pages     = {557 -- 576},
  year      = {2015},
  abstract  = {Background Balance training (BT) has been used for the promotion of balance and sports-related skills as well as for prevention and rehabilitation of lower extremity sport injuries. However, evidence-based dose-response relationships in BT parameters have not yet been established. Objective The objective of this systematic literature review and meta-analysis was to determine dose-response relationships in BT parameters that lead to improvements in balance in young healthy adults with different training status. Data Sources A computerized systematic literature search was performed in the electronic databases PubMed, Web of Knowledge, and SPORTDiscus from January 1984 up to May 2014 to capture all articles related to BT in young healthy adults. Study Eligibility Criteria A systematic approach was used to evaluate the 596 articles identified for initial review. Only randomized controlled studies were included if they investigated BT in young healthy adults (16-40 years) and tested at least one behavioral balance performance outcome. In total, 25 studies met the inclusion criteria for review. Study Appraisal and Synthesis Methods Studies were evaluated using the physiotherapy evidence database (PEDro) scale. Within-subject effect sizes (ESdw) and between-subject effect sizes (ESdb) were calculated. The included studies were coded for the following criteria: training status (elite athletes, sub-elite athletes, recreational athletes, untrained subjects), training modalities (training period, frequency, volume, etc.), and balance outcome (test for the assessment of steady-state, proactive, and reactive balance). Results Mean ESdb demonstrated that BT is an effective means to improve steady-state (ESdb = 0.73) and proactive balance (ESdb = 0.92) in healthy young adults. Studies including elite athletes showed the largest effects (ESdb = 1.29) on measures of steady-state balance as compared with studies analyzing sub-elite athletes (ESdb = 0.32), recreational athletes (ESdb = 0.69), and untrained subjects (ESdb = 0.82). Our analyses regarding dose-response relationships in BT revealed that a training period of 11-12 weeks (ESdb = 1.09), a training frequency of three (mean ESdb = 0.72) or six (single ESdb = 1.84) sessions per week, at least 16-19 training sessions in total (ESdb = 1.12), a duration of 11-15 min for a single training session (ESdb = 1.11), four exercises per training session (ESdb = 1.29), two sets per exercise (ESdb = 1.63), and a duration of 21-40 s for a single BT exercise (ESdb = 1.06) is most effective in improving measures of steady-state balance. Due to a small number of studies, dose-response relationships of BT for measures of proactive and reactive balance could not be qualified. Limitations The present findings must be interpreted with caution because it is difficult to separate the impact of a single training modality (e.g., training frequency) from that of the others. Moreover, the quality of the included studies was rather limited, with a mean PEDro score of 5. Conclusions Our detailed analyses revealed effective BT parameters for the improvement of steady-state balance. Thus, practitioners and coaches are advised to consult the identified dose-response relationships of this systematic literature review and meta-analysis to implement effective BT protocols in clinical and sports-related contexts. However, further research of high methodological quality is needed to (1) determine dose-response relationships of BT for measures of proactive and reactive balance, (2) define effective sequencing protocols in BT (e.g., BT before or after a regular training session), (3) discern the effects of detraining, and (4) develop a feasible and effective method to regulate training intensity in BT.},
  language  = {en}
}
@misc{LacroixHortobagyiBeurskensetal.2017,
  author    = {Lacroix, Andre and Hortobagyi, Tibor and Beurskens, Rainer and Granacher, Urs},
  title     = {Effects of Supervised vs. Unsupervised Training Programs on Balance and Muscle Strength in Older Adults: A Systematic Review and Meta-Analysis},
  series = {Sports medicine},
  volume    = {47},
  journal   = {Sports medicine},
  publisher = {Springer},
  address   = {Northcote},
  issn      = {0112-1642},
  doi       = {10.1007/s40279-017-0747-6},
  pages     = {2341 -- 2361},
  year      = {2017},
  abstract  = {Objectives The objective of this systematic review and meta-analysis was to quantify the effectiveness of supervised vs. unsupervised balance and/or resistance training programs on measures of balance and muscle strength/ power in healthy older adults. In addition, the impact of supervision on training-induced adaptive processes was evaluated in the form of dose-response relationships by analyzing randomized controlled trials that compared supervised with unsupervised trials. Data Sources A computerized systematic literature search was performed in the electronic databases PubMed, Web of Science, and SportDiscus to detect articles examining the role of supervision in balance and/or resistance training in older adults. Study Eligibility Criteria The initially identified 6041 articles were systematically screened. Studies were included if they examined balance and/or resistance training in adults aged >= 65 years with no relevant diseases and registered at least one behavioral balance (e.g., time during single leg stance) and/or muscle strength/ power outcome (e.g., time for 5-Times-Chair-Rise-Test). Finally, 11 studies were eligible for inclusion in this meta-analysis. Study Appraisal Weighted mean standardized mean differences between subjects (SMDbs) of supervised vs. unsupervised balance/resistance training studies were calculated. The included studies were coded for the following variables: number of participants, sex, age, number and type of interventions, type of balance/strength tests, and change (\%) from pre- to post-intervention values. Additionally, we coded training according to the following modalities: period, frequency, volume, modalities of supervision (i.e., number of supervised/unsupervised sessions within the supervised or unsupervised training groups, respectively). Heterogeneity was computed using I 2 and chi(2) statistics. The methodological quality of the included studies was evaluated using the Physiotherapy Evidence Database scale. Results Our analyses revealed that in older adults, supervised balance/resistance training was superior compared with unsupervised balance/resistance training in improving measures of static steady-state balance (mean SMDbs = 0.28, p = 0.39), dynamic steady-state balance (mean SMDbs = 0.35, p = 0.02), proactive balance (mean SMDbs = 0.24, p = 0.05), balance test batteries (mean SMDbs = 0.53, p = 0.02), and measures of muscle strength/power (mean SMDbs = 0.51, p = 0.04). Regarding the examined dose-response relationships, our analyses showed that a number of 10-29 additional supervised sessions in the supervised training groups compared with the unsupervised training groups resulted in the largest effects for static steady-state balance (mean SMDbs = 0.35), dynamic steady-state balance (mean SMDbs = 0.37), and muscle strength/power (mean SMDbs = 1.12). Further, >= 30 additional supervised sessions in the supervised training groups were needed to produce the largest effects on proactive balance (mean SMDbs = 0.30) and balance test batteries (mean SMDbs = 0.77). Effects in favor of supervised programs were larger for studies that did not include any supervised sessions in their unsupervised programs (mean SMDbs: 0.28-1.24) compared with studies that implemented a few supervised sessions in their unsupervised programs (e.g., three supervised sessions throughout the entire intervention program; SMDbs: -0.06 to 0.41). Limitations The present findings have to be interpreted with caution because of the low number of eligible studies and the moderate methodological quality of the included studies, which is indicated by a median Physiotherapy Evidence Database scale score of 5. Furthermore, we indirectly compared dose-response relationships across studies and not from single controlled studies. Conclusions Our analyses suggest that supervised balance and/or resistance training improved measures of balance and muscle strength/power to a greater extent than unsupervised programs in older adults. Owing to the small number of available studies, we were unable to establish a clear dose-response relationship with regard to the impact of supervision. However, the positive effects of supervised training are particularly prominent when compared with completely unsupervised training programs. It is therefore recommended to include supervised sessions (i.e., two out of three sessions/week) in balance/resistance training programs to effectively improve balance and muscle strength/power in older adults.},
  language  = {en}
}
@article{HortobagyiUematsuSandersetal.2018,
  author    = {Hortobagyi, Tibor and Uematsu, Azusa and Sanders, Lianne and Kliegl, Reinhold and Tollar, Jozsef and Moraes, Renato and Granacher, Urs},
  title     = {Beam Walking to Assess Dynamic Balance in Health and Disease},
  series = {Gerontology},
  volume    = {65},
  journal   = {Gerontology},
  number    = {4},
  publisher = {Karger},
  address   = {Basel},
  issn      = {0304-324X},
  doi       = {10.1159/000493360},
  pages     = {332 -- 339},
  year      = {2018},
  abstract  = {Background: Dynamic balance keeps the vertical projection of the center of mass within the base of support while walking. Dynamic balance tests are used to predict the risks of falls and eventual falls. The psychometric properties of most dynamic balance tests are unsatisfactory and do not comprise an actual loss of balance while walking. Objectives: Using beam walking distance as a measure of dynamic balance, the BEAM consortium will determine the psychometric properties, lifespan and patient reference values, the relationship with selected "dynamic balance tests," and the accuracy of beam walking distance to predict falls. Methods: This cross-sectional observational study will examine healthy adults in 7 decades (n = 432) at 4 centers. Center 5 will examine patients (n = 100) diagnosed with Parkinson's disease, multiple sclerosis, stroke, and balance disorders. In test 1, all participants will be measured for demographics, medical history, muscle strength, gait, static balance, dynamic balance using beam walking under single (beam walking only) and dual task conditions (beam walking while concurrently performing an arithmetic task), and several cognitive functions. Patients and healthy participants age 50 years or older will be additionally measured for fear of falling, history of falls, miniBESTest, functional reach on a force platform, timed up and go, and reactive balance. All participants age 50 years or older will be recalled to report fear of falling and fall history 6 and 12 months after test 1. In test 2, seven to ten days after test 1, healthy young adults and age 50 years or older (n = 40) will be retested for reliability of beam walking performance. Conclusion: We expect to find that beam walking performance vis-{\`a}-vis the traditionally used balance outcomes predicts more accurately fall risks and falls. Clinical Trial Registration Number: NCT03532984.},
  language  = {en}
}
@misc{HortobagyiLesinskiGableretal.2016,
  author    = {Hortobagyi, Tibor and Lesinski, Melanie and Gabler, Martijn and VanSwearingen, Jessie M. and Malatesta, Davide and Granacher, Urs},
  title     = {Gait Speed: A Systematic Review and Meta-Analysis (vol 45, pg 1627, 2015)},
  series = {Sports medicine},
  volume    = {46},
  journal   = {Sports medicine},
  publisher = {Springer},
  address   = {Northcote},
  issn      = {0112-1642},
  doi       = {10.1007/s40279-016-0498-9},
  pages     = {453 -- 453},
  year      = {2016},
  language  = {en}
}
@misc{HortobagyiLesinskiFernandezdelOlmoetal.2015,
  author    = {Hortobagyi, Tibor and Lesinski, Melanie and Fernandez-del-Olmo, Miguel and Granacher, Urs},
  title     = {Small and inconsistent effects of whole body vibration on athletic performance: a systematic review and meta-analysis},
  series = {European journal of applied physiology},
  volume    = {115},
  journal   = {European journal of applied physiology},
  number    = {8},
  publisher = {Springer},
  address   = {New York},
  issn      = {1439-6319},
  doi       = {10.1007/s00421-015-3194-9},
  pages     = {1605 -- 1625},
  year      = {2015},
  abstract  = {We quantified the acute and chronic effects of whole body vibration on athletic performance or its proxy measures in competitive and/or elite athletes. Systematic literature review and meta-analysis. Whole body vibration combined with exercise had an overall 0.3 \% acute effect on maximal voluntary leg force (-6.4 \%, effect size = -0.43, 1 study), leg power (4.7 \%, weighted mean effect size = 0.30, 6 studies), flexibility (4.6 \%, effect size = -0.12 to 0.22, 2 studies), and athletic performance (-1.9 \%, weighted mean effect size = 0.26, 6 studies) in 191 (103 male, 88 female) athletes representing eight sports (overall effect size = 0.28). Whole body vibration combined with exercise had an overall 10.2 \% chronic effect on maximal voluntary leg force (14.6 \%, weighted mean effect size = 0.44, 5 studies), leg power (10.7 \%, weighted mean effect size = 0.42, 9 studies), flexibility (16.5 \%, effect size = 0.57 to 0.61, 2 studies), and athletic performance (-1.2 \%, weighted mean effect size = 0.45, 5 studies) in 437 (169 male, 268 female) athletes (overall effect size = 0.44). Whole body vibration has small and inconsistent acute and chronic effects on athletic performance in competitive and/or elite athletes. These findings lead to the hypothesis that neuromuscular adaptive processes following whole body vibration are not specific enough to enhance athletic performance. Thus, other types of exercise programs (e.g., resistance training) are recommended if the goal is to improve athletic performance.},
  language  = {en}
}
@article{HortobagyiGranacherFernandezdelOlmoetal.2020,
  author    = {Hortobagyi, Tibor and Granacher, Urs and Fernandez-del-Olmo, Miguel and Howatson, Glyn and Manca, Andrea and Deriu, Franca and Taube, Wolfgang and Gruber, Markus and Marquez, Gonzalo and Lundbye-Jensen, Jesper and Colomer-Poveda, David},
  title     = {Functional relevance of resistance training-induced neuroplasticity in health and disease},
  series = {Neuroscience \& biobehavioral reviews : official journal of the International Behavioral Neuroscience Society},
  volume    = {122},
  journal   = {Neuroscience \& biobehavioral reviews : official journal of the International Behavioral Neuroscience Society},
  publisher = {Elsevier},
  address   = {Oxford},
  issn      = {0149-7634},
  doi       = {10.1016/j.neubiorev.2020.12.019},
  pages     = {79 -- 91},
  year      = {2020},
  abstract  = {Repetitive, monotonic, and effortful voluntary muscle contractions performed for just a few weeks, i.e., resistance training, can substantially increase maximal voluntary force in the practiced task and can also increase gross motor performance. The increase in motor performance is often accompanied by neuroplastic adaptations in the central nervous system. While historical data assigned functional relevance to such adaptations induced by resistance training, this claim has not yet been systematically and critically examined in the context of motor performance across the lifespan in health and disease. A review of muscle activation, brain and peripheral nerve stimulation, and imaging data revealed that increases in motor performance and neuroplasticity tend to be uncoupled, making a mechanistic link between neuroplasticity and motor performance inconclusive. We recommend new approaches, including causal mediation analytical and hypothesis-driven models to substantiate the functional relevance of resistance training-induced neuroplasticity in the improvements of gross motor function across the lifespan in health and disease.},
  language  = {en}
}
@article{HortobagyiDeakFarkasetal.2021,
  author    = {Hortobagyi, Tibor and Deak, Dorina and Farkas, Dora and Blenyesi, Eszter and Torok, Katalin and Granacher, Urs and Tollar, Jozsef},
  title     = {Effects of exercise dose and detraining duration on mobility at late midlife},
  series = {Gerontology},
  volume    = {67},
  journal   = {Gerontology},
  number    = {4},
  publisher = {Karger},
  address   = {Basel},
  issn      = {0304-324X},
  doi       = {10.1159/000513505},
  pages     = {403 -- 414},
  year      = {2021},
  abstract  = {Background: Office workers near retirement tend to be sedentary and can be prone to mobility limitations and diseases. We examined the dose effects of exergaming volume and duration of detraining on motor and cognitive function in office workers at late midlife to reduce sedentariness and mobility limitations. Methods: In an assessor-blinded randomized trial, 160 workers aged 55-65 years performed physically active video games in a nonimmersive form of virtual reality (exergaming) in small, supervised groups for 1 h, 1x, 2x, or 3x/week for 8 weeks followed by detraining for 8 and 16 weeks. Exergaming comprises high-intensity, full-body sensorimotor coordination, balance, endurance, and strengthening exercises. The primary outcome was the 6-minute walk test (6MWT), and secondary outcomes were body mass, self-reported physical activity, sleep quality, Berg Balance Scale, Short Physical Performance Battery, fast gait speed, dynamic balance, heart rate recovery after step test, and 6 cognitive tests. Results: The 3 groups were not different in any of the outcomes at baseline (all p > 0.05). The outcomes were stable and had acceptable reliability (intraclass correlation coefficients >= 0.334) over an 8-week control period. Training produced an inverted U-shaped dose response of no (1x), most (2x), and medium (3x/week) effects of exergaming volume in most motor and selected cognitive outcomes. The distance walked in the 6MWT (primary outcome) increased most (94 m, 19\%, p < 0.05), medium (57 m, 12\%, p < 0.05), and least (4 m, 1\%) after exergaming 2x, 3x, or 0x (control) (all different p < 0.05). The highest responders tended to retain the exercise effects over 8 weeks of detraining, independent of training volume. This maintenance effect was less consistent after 16 weeks of detraining. Conclusion: Less was more during training and lasted longer after detraining. A medium dose volume of exergaming produced the largest clinically meaningful improvements in mobility and selected cognitive tests in 60-year-old office workers with mild mobility limitations and intact cognition.},
  language  = {en}
}
@article{GaeblerPrieskeHortobagyietal.2018,
  author    = {G{\"a}bler, Martijn and Prieske, Olaf and Hortobagyi, Tibor and Granacher, Urs},
  title     = {The Effects of Concurrent Strength and Endurance Training on Physical Fitness and Athletic Performance in Youth},
  series = {Frontiers in Physiology},
  volume    = {9},
  journal   = {Frontiers in Physiology},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-042X},
  doi       = {10.3389/fphys.2018.01057},
  pages     = {1 -- 13},
  year      = {2018},
  abstract  = {Combining training of muscle strength and cardiorespiratory fitness within a training cycle could increase athletic performance more than single-mode training. However, the physiological effects produced by each training modality could also interfere with each other, improving athletic performance less than single-mode training. Because anthropometric, physiological, and biomechanical differences between young and adult athletes can affect the responses to exercise training, young athletes might respond differently to concurrent training (CT) compared with adults. Thus, the aim of the present systematic review with meta-analysis was to determine the effects of concurrent strength and endurance training on selected physical fitness components and athletic performance in youth. A systematic literature search of PubMed and Web of Science identified 886 records. The studies included in the analyses examined children (girls age 6-11 years, boys age 6-13 years) or adolescents (girls age 12-18 years, boys age 14-18 years), compared CT with single-mode endurance (ET) or strength training (ST), and reported at least one strength/power—(e.g., jump height), endurance—(e.g., peak V°O2, exercise economy), or performance-related (e.g., time trial) outcome. We calculated weighted standardized mean differences (SMDs). CT compared to ET produced small effects in favor of CT on athletic performance (n = 11 studies, SMD = 0.41, p = 0.04) and trivial effects on cardiorespiratory endurance (n = 4 studies, SMD = 0.04, p = 0.86) and exercise economy (n = 5 studies, SMD = 0.16, p = 0.49) in young athletes. A sub-analysis of chronological age revealed a trend toward larger effects of CT vs. ET on athletic performance in adolescents (SMD = 0.52) compared with children (SMD = 0.17). CT compared with ST had small effects in favor of CT on muscle power (n = 4 studies, SMD = 0.23, p = 0.04). In conclusion, CT is more effective than single-mode ET or ST in improving selected measures of physical fitness and athletic performance in youth. Specifically, CT compared with ET improved athletic performance in children and particularly adolescents. Finally, CT was more effective than ST in improving muscle power in youth.},
  language  = {en}
}
@misc{GaeblerPrieskeHortobagyietal.2018,
  author    = {G{\"a}bler, Martijn and Prieske, Olaf and Hortobagyi, Tibor and Granacher, Urs},
  title     = {The Effects of Concurrent Strength and Endurance Training on Physical Fitness and Athletic Performance in Youth},
  series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  number    = {471},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-417683},
  pages     = {13},
  year      = {2018},
  abstract  = {Combining training of muscle strength and cardiorespiratory fitness within a training cycle could increase athletic performance more than single-mode training. However, the physiological effects produced by each training modality could also interfere with each other, improving athletic performance less than single-mode training. Because anthropometric, physiological, and biomechanical differences between young and adult athletes can affect the responses to exercise training, young athletes might respond differently to concurrent training (CT) compared with adults. Thus, the aim of the present systematic review with meta-analysis was to determine the effects of concurrent strength and endurance training on selected physical fitness components and athletic performance in youth. A systematic literature search of PubMed and Web of Science identified 886 records. The studies included in the analyses examined children (girls age 6-11 years, boys age 6-13 years) or adolescents (girls age 12-18 years, boys age 14-18 years), compared CT with single-mode endurance (ET) or strength training (ST), and reported at least one strength/power—(e.g., jump height), endurance—(e.g., peak V°O2, exercise economy), or performance-related (e.g., time trial) outcome. We calculated weighted standardized mean differences (SMDs). CT compared to ET produced small effects in favor of CT on athletic performance (n = 11 studies, SMD = 0.41, p = 0.04) and trivial effects on cardiorespiratory endurance (n = 4 studies, SMD = 0.04, p = 0.86) and exercise economy (n = 5 studies, SMD = 0.16, p = 0.49) in young athletes. A sub-analysis of chronological age revealed a trend toward larger effects of CT vs. ET on athletic performance in adolescents (SMD = 0.52) compared with children (SMD = 0.17). CT compared with ST had small effects in favor of CT on muscle power (n = 4 studies, SMD = 0.23, p = 0.04). In conclusion, CT is more effective than single-mode ET or ST in improving selected measures of physical fitness and athletic performance in youth. Specifically, CT compared with ET improved athletic performance in children and particularly adolescents. Finally, CT was more effective than ST in improving muscle power in youth.},
  language  = {en}
}
@misc{GaeblerBerberyanPrieskeetal.2022,
  author    = {G{\"a}bler, Martijn and Berberyan, Hermine S. and Prieske, Olaf and Elferink-Gemser, Marije Titia and Hortobagyi, Tibor and Warnke, Torsten and Granacher, Urs},
  title     = {Strength Training Intensity and Volume Affect Performance of Young Kayakers/Canoeists},
  series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  journal   = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {1866-8364},
  doi       = {10.25932/publishup-54228},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-542283},
  pages     = {1 -- 10},
  year      = {2022},
  abstract  = {Purpose: The aim of this study was to compare the effects of moderate intensity, low volume (MILV) vs. low intensity, high volume (LIHV) strength training on sport-specific performance, measures of muscular fitness, and skeletal muscle mass in young kayakers and canoeists. Methods: Semi-elite young kayakers and canoeists (N = 40, 13 ± 0.8 years, 11 girls) performed either MILV (70-80\% 1-RM, 6-12 repetitions per set) or LIHV (30-40\% 1-RM, 60-120 repetitions per set) strength training for one season. Linear mixed-effects models were used to compare effects of training condition on changes over time in 250 and 2,000 m time trials, handgrip strength, underhand shot throw, average bench pull power over 2 min, and skeletal muscle mass. Both between- and within-subject designs were used for analysis. An alpha of 0.05 was used to determine statistical significance. Results: Between- and within-subject analyses showed that monthly changes were greater in LIHV vs. MILV for the 2,000 m time trial (between: 9.16 s, SE = 2.70, p < 0.01; within: 2,000 m: 13.90 s, SE = 5.02, p = 0.01) and bench pull average power (between: 0.021 W⋅kg-1, SE = 0.008, p = 0.02; within: 0.010 W⋅kg-1, SE = 0.009, p > 0.05). Training conditions did not affect other outcomes. Conclusion: Young sprint kayakers and canoeists benefit from LIHV more than MILV strength training in terms of 2,000 m performance and muscular endurance (i.e., 2 min bench pull power).},
  language  = {en}
}
@misc{GranacherGollhoferHortobagyietal.2013,
  author    = {Granacher, Urs and Gollhofer, Albert and Hortobagyi, Tibor and Kressig, Reto W. and M{\"u}hlbauer, Thomas},
  title     = {The importance of trunk muscle strength for balance, functional performance, and fall prevention in seniors a systematic review},
  series = {Sports medicine},
  volume    = {43},
  journal   = {Sports medicine},
  number    = {7},
  publisher = {Springer},
  address   = {Auckland},
  issn      = {0112-1642},
  doi       = {10.1007/s40279-013-0041-1},
  pages     = {627 -- 641},
  year      = {2013},
  abstract  = {Background The aging process results in a number of functional (e.g., deficits in balance and strength/power performance), neural (e.g., loss of sensory/motor neurons), muscular (e.g., atrophy of type-II muscle fibers in particular), and bone-related (e.g., osteoporosis) deteriorations. Traditionally, balance and/or lower extremity resistance training were used to mitigate these age-related deficits. However, the effects of resistance training are limited and poorly translate into improvements in balance, functional tasks, activities of daily living, and fall rates. Thus, it is necessary to develop and design new intervention programs that are specifically tailored to counteract age-related weaknesses. Recent studies indicate that measures of trunk muscle strength (TMS) are associated with variables of static/dynamic balance, functional performance, and falls (i.e., occurrence, fear, rate, and/or risk of falls). Further, there is preliminary evidence in the literature that core strength training (CST) and Pilates exercise training (PET) have a positive influence on measures of strength, balance, functional performance, and falls in older adults. Objective The objectives of this systematic literature review are: (a) to report potential associations between TMS/trunk muscle composition and balance, functional performance, and falls in old adults, and (b) to describe and discuss the effects of CST/PET on measures of TMS, balance, functional performance, and falls in seniors. Data Sources A systematic approach was employed to capture all articles related to TMS/trunk muscle composition, balance, functional performance, and falls in seniors that were identified using the electronic databases PubMed and Web of Science (1972 to February 2013). Study Selection A systematic approach was used to evaluate the 582 articles identified for initial review. Cross-sectional (i.e., relationship) or longitudinal (i.e., intervention) studies were included if they investigated TMS and an outcome-related measure of balance, functional performance, and/or falls. In total, 20 studies met the inclusionary criteria for review. Study Appraisal and Synthesis Methods Longitudinal studies were evaluated using the Physiotherapy Evidence Database (PEDro) scale. Effect sizes (ES) were calculated whenever possible. For ease of discussion, the 20 articles were separated into three groups [i.e., cross-sectional (n = 6), CST (n = 9), PET (n = 5)]. Results The cross-sectional studies reported small-to-medium correlations between TMS/trunk muscle composition and balance, functional performance, and falls in older adults. Further, CST and/or PET proved to be feasible exercise programs for seniors with high-adherence rates. Age-related deficits in measures of TMS, balance, functional performance, and falls can be mitigated by CST (mean strength gain = 30 \%, mean effect size = 0.99; mean balance/functional performance gain = 23 \%, mean ES = 0.88) and by PET (mean strength gain = 12 \%, mean ES = 0.52; mean balance/functional performance gain = 18 \%, mean ES = 0.71). Limitations Given that the mean PEDro quality score did not reach the predetermined cut-off of >= 6 for the intervention studies, there is a need for more high-quality studies to explicitly identify the relevance of CST and PET to the elderly population. Conclusions Core strength training and/or PET can be used as an adjunct or even alternative to traditional balance and/or resistance training programs for old adults. Further, CST and PET are easy to administer in a group setting or in individual fall preventive or rehabilitative intervention programs because little equipment and space is needed to perform such exercises.},
  language  = {en}
}
@misc{GaeblerPrieskeHortobagyietal.2018,
  author    = {Gaebler, Martijn and Prieske, Olaf and Hortobagyi, Tibor and Granacher, Urs},
  title     = {The effects of concurrent strength and endurance training on physical fitness and athletic performance in Youth},
  series = {Frontiers in physiology},
  volume    = {9},
  journal   = {Frontiers in physiology},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-042X},
  doi       = {10.3389/fphys.2018.01057},
  pages     = {13},
  year      = {2018},
  abstract  = {Combining training of muscle strength and cardiorespiratory fitness within a training cycle could increase athletic performance more than single-mode training. However, the physiological effects produced by each training modality could also interfere with each other, improving athletic performance less than single-mode training. Because anthropometric, physiological, and biomechanical differences between young and adult athletes can affect the responses to exercise training, young athletes might respond differently to concurrent training (CT) compared with adults. Thus, the aim of the present systematic review with meta-analysis was to determine the effects of concurrent strength and endurance training on selected physical fitness components and athletic performance in youth. A systematic literature search of PubMed and Web of Science identified 886 records. The studies included in the analyses examined children (girls age 6-11 years, boys age 6-13 years) or adolescents (girls age 12-18 years, boys age 14-18 years), compared CT with single-mode endurance (ET) or strength training (ST), and reported at least one strength/power-(e.g., jump height), endurance-(e.g., peak. VO2, exercise economy), or performance-related (e.g., time trial) outcome. We calculated weighted standardized mean differences (SMDs). CT compared to ET produced small effects in favor of CT on athletic performance (n = 11 studies, SMD = 0.41, p = 0.04) and trivial effects on cardiorespiratory endurance (n = 4 studies, SMD = 0.04, p = 0.86) and exercise economy (n = 5 studies, SMD = 0.16, p = 0.49) in young athletes. A sub-analysis of chronological age revealed a trend toward larger effects of CT vs. ET on athletic performance in adolescents (SMD = 0.52) compared with children (SMD = 0.17). CT compared with ST had small effects in favor of CT on muscle power (n = 4 studies, SMD = 0.23, p = 0.04). In conclusion, CT is more effective than single-mode ET or ST in improving selected measures of physical fitness and athletic performance in youth. Specifically, CT compared with ET improved athletic performance in children and particularly adolescents. Finally, CT was more effective than ST in improving muscle power in youth.},
  language  = {en}
}
@article{daSilvaCostaHortobagyidenOtteretal.2022,
  author    = {da Silva Costa, Andreia Abud and Hortobagyi, Tibor and den Otter, Rob and Sawers, Andrew and Moraes, Renato},
  title     = {Beam width and arm position but not cognitive task affect walking balance in older adults},
  series = {Scientific reports},
  volume    = {12},
  journal   = {Scientific reports},
  number    = {1},
  publisher = {Nature Research},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-022-10848-y},
  pages     = {10},
  year      = {2022},
  abstract  = {Detection of changes in dynamic balance could help identify older adults at fall risk. Walking on a narrow beam with its width, cognitive load, and arm position manipulated could be an alternative to current tests. Therefore, we examined additive and interactive effects of beam width, cognitive task (CT), and arm position on dynamic balance during beam walking in older adults. Twenty older adults (69 +/- 4y) walked on 6, 8, and 10-cm wide beams (2-cm high, 4-m-long), with and without CT, with three arm positions (free, crossed, akimbo). We determined cognitive errors, distance walked, step speed, root mean square (RMS) of center of mass (COM) displacement and trunk acceleration in the frontal plane. Beam width decrease progressively reduced distance walked and increased trunk acceleration RMS. Step speed decreased on the narrowest beam and with CT. Arm crossing decreased distance walked and step speed. COM displacement RMS and cognitive errors were not affected by any manipulation. In conclusion, distance walked indicated that beam width and arm position, but less so CT, affected dynamic balance, implying that beam walking has the potential to become a test of fall risk. Stability measurements suggested effective trunk adjustments to control COM position and keep dynamic balance during the task.},
  language  = {en}
}
@article{BeijersbergenHortobagyiBeurskensetal.2016,
  author    = {Beijersbergen, Chantal M. I. and Hortobagyi, Tibor and Beurskens, Rainer and Lenzen-Grossimlinghaus, Romana and Gabler, Martijn and Granacher, Urs},
  title     = {Effects of Power Training on Mobility and Gait Biomechanics in Old Adults with Moderate Mobility Disability: Protocol and Design of the Potsdam Gait Study (POGS)},
  series = {Gerontology},
  volume    = {62},
  journal   = {Gerontology},
  publisher = {Karger},
  address   = {Basel},
  issn      = {0304-324X},
  doi       = {10.1159/000444752},
  pages     = {597 -- 603},
  year      = {2016},
  abstract  = {Background: Walking speed decreases in old age. Even though old adults regularly participate in exercise interventions, we do not know how the intervention-induced changes in physical abilities produce faster walking. The Potsdam Gait Study (POGS) will examine the effects of 10 weeks of power training and detraining on leg muscle power and, for the first time, on complete gait biomechanics, including joint kinematics, kinetics, and muscle activation in old adults with moderate mobility disability. Methods/Design: POGS is a randomized controlled trial with two arms, each crossed over, without blinding. Arm 1 starts with a 10-week control period to assess the reliability of the tests and is then crossed over to complete 25-30 training sessions over 10 weeks. Arm 2 completes 25-30 exercise sessions over 10 weeks, followed by a 10-week follow-up (detraining) period. The exercise program is designed to improve lower extremity muscle power. Main outcome measures are: muscle power, gait speed, and gait biomechanics measured at baseline and after 10 weeks of training and 10 weeks of detraining. Discussion: It is expected that power training will increase leg muscle power measured by the weight lifted and by dynamometry, and these increased abilities become expressed in joint powers measured during gait. Such favorably modified powers will underlie the increase in step length, leading ultimately to a faster walking speed. POGS will increase our basic understanding of the biomechanical mechanisms of how power training improves gait speed in old adults with moderate levels of mobility disabilities. (C) 2016 S. Karger AG, Basel},
  language  = {en}
}
@misc{BeijersbergenGranacherVandervoortetal.2013,
  author    = {Beijersbergen, Chantal M. I. and Granacher, Urs and Vandervoort, A. A. and DeVita, P. and Hortobagyi, Tibor},
  title     = {The biomechanical mechanism of how strength and power training improves walking speed in old adults remains unknown},
  series = {Ageing research reviews : ARR},
  volume    = {12},
  journal   = {Ageing research reviews : ARR},
  number    = {2},
  publisher = {Elsevier},
  address   = {Clare},
  issn      = {1568-1637},
  doi       = {10.1016/j.arr.2013.03.001},
  pages     = {618 -- 627},
  year      = {2013},
  abstract  = {Maintaining and increasing walking speed in old age is clinically important because this activity of daily living predicts functional and clinical state. We reviewed evidence for the biomechanical mechanisms of how strength and power training increase gait speed in old adults. A systematic search yielded only four studies that reported changes in selected gait biomechanical variables after an intervention. A secondary analysis of 20 studies revealed an association of r(2) = 0.21 between the 22\% and 12\% increase, respectively, in quadriceps strength and gait velocity in 815 individuals age 72. In 6 studies, there was a correlation of r(2) = 0.16 between the 19\% and 9\% gains in plantarflexion strength and gait speed in 240 old volunteers age 75. In 8 studies, there was zero association between the 35\% and 13\% gains in leg mechanical power and gait speed in 150 old adults age 73. To increase the efficacy of intervention studies designed to improve gait speed and other critical mobility functions in old adults, there is a need for a paradigm shift from conventional (clinical) outcome assessments to more sophisticated biomechanical analyses that examine joint kinematics, kinetics, energetics, muscle-tendon function, and musculoskeletal modeling before and after interventions.},
  language  = {en}
}