@article{ZochLesniakDobberkeSchlittetal.2020, author = {Zoch-Lesniak, Beate and Dobberke, Jeanette and Schlitt, Axel and Bongarth, Christa and Glatz, Johannes and Sp{\"o}rl-D{\"o}nch, Sieglinde and Koran, Iryna and V{\"o}ller, Heinz and Salzwedel, Annett}, title = {Performance Measures for Short-Term Cardiac Rehabilitation in Patients of Working Age}, series = {Archives of Rehabilitation Research and Clinical Translation}, volume = {2}, journal = {Archives of Rehabilitation Research and Clinical Translation}, publisher = {Elsevier}, address = {Amsterdam}, issn = {2590-1095}, doi = {10.1016/j.arrct.2020.100043}, pages = {14}, year = {2020}, abstract = {Objective: To determine immediate performance measures for short-term, multicomponent cardiac rehabilitation (CR) in clinical routine in patients of working age, taking into account cardiovascular risk factors, physical performance, social medicine, and subjective health parameters and to explore the underlying dimensionality. Design: Prospective observational multicenter register study in 12 rehabilitation centers throughout Germany. Setting: Comprehensive 3-week CR.}, language = {en} } @article{VoellerSalzwedelNitardyetal.2015, author = {V{\"o}ller, Heinz and Salzwedel, Annett and Nitardy, Aischa and Buhlert, Hermann and Treszl, Andras and Wegscheider, Karl}, title = {Effect of cardiac rehabilitation on functional and emotional status in patients after transcatheter aortic-valve implantation}, series = {European journal of preventive cardiology : the official ESC journal for primary \& secondary cardiovascular prevention, rehabilitation and sports cardiology}, volume = {22}, journal = {European journal of preventive cardiology : the official ESC journal for primary \& secondary cardiovascular prevention, rehabilitation and sports cardiology}, number = {5}, publisher = {Sage Publ.}, address = {London}, issn = {2047-4873}, doi = {10.1177/2047487314526072}, pages = {568 -- 574}, year = {2015}, abstract = {Background Transcatheter aortic-valve implantation (TAVI) is an established alternative therapy in patients with severe aortic stenosis and a high surgical risk. Despite a rapid growth in its use, very few data exist about the efficacy of cardiac rehabilitation (CR) in these patients. We assessed the hypothesis that patients after TAVI benefit from CR, compared to patients after surgical aortic-valve replacement (sAVR). Methods From September 2009 to August 2011, 442 consecutive patients after TAVI (n=76) or sAVR (n=366) were referred to a 3-week CR. Data regarding patient characteristics as well as changes of functional (6-min walk test. 6-MWT), bicycle exercise test), and emotional status (Hospital Anxiety and Depression Scale) were retrospectively evaluated and compared between groups after propensity score adjustment. Results Patients after TAVI were significantly older (p<0.001), more female (p<0.001), and had more often coronary artery disease (p=0.027), renal failure (p=0.012) and a pacemaker (p=0.032). During CR, distance in 6-MWT (both groups p0.001) and exercise capacity (sAVR p0.001, TAVI p0.05) significantly increased in both groups. Only patients after sAVR demonstrated a significant reduction in anxiety and depression (p0.001). After propensity scores adjustment, changes were not significantly different between sAVR and TAVI, with the exception of 6-MWT (p=0.004). Conclusions Patients after TAVI benefit from cardiac rehabilitation despite their older age and comorbidities. CR is a helpful tool to maintain independency for daily life activities and participation in socio-cultural life.}, language = {en} } @article{SchulzBehrendtSalzwedelRabeetal.2017, author = {Schulz-Behrendt, Claudia and Salzwedel, Annett and Rabe, Sophie and Ortmann, K. and V{\"o}ller, Heinz}, title = {Aspekte beruflicher und sozialer Wiedereingliederung aus Sicht kardiovaskul{\"a}r erkrankter Rehabilitanden in besonderen beruflichen Problemlagen}, series = {Die Rehabilitation : Zeitschrift f{\"u}r Praxis und Forschung in der Rehabilitation}, volume = {56}, journal = {Die Rehabilitation : Zeitschrift f{\"u}r Praxis und Forschung in der Rehabilitation}, number = {3}, publisher = {Thieme}, address = {Stuttgart}, issn = {0034-3536}, doi = {10.1055/s-0042-121379}, pages = {181 -- 188}, year = {2017}, abstract = {Ziel: Untersucht wurden subjektive bio-psycho-soziale Auswirkungen chronischer Herz- und Gef{\"a}ßerkrankungen, Bew{\"a}ltigungsstrategien und Formen sozialer Unterst{\"u}tzung bei Rehabilitanden in besonderen beruflichen Problemlagen (BBPL). Methodik: F{\"u}r die qualitative Untersuchung wurden 17 Patienten (48,9±7,0 Jahre, 13 m{\"a}nnl.) mit BBPL (SIMBO-C>30) in leitfadengest{\"u}tzten Interviews befragt. Die Auswertung erfolgte softwaregest{\"u}tzt nach dem inhaltsanalytischen Ansatz von Mayring. Ergebnisse: Im Rahmen der Krankheitsauswirkungen benannten die Patienten soziale, einschließlich beruflicher Aspekte mit 62\% der Aussagen deutlich h{\"a}ufiger als physische oder psychische Faktoren (9 bzw. 29\%). Angewandte Bew{\"a}ltigungsstrategien und erfahrene Unterst{\"u}tzungsleistungen richteten sich jedoch {\"u}berwiegend auf k{\"o}rperliche Einschr{\"a}nkungen (70 bzw. 45\%). Schlussfolgerung: Obgleich soziale Krankheitsauswirkungen f{\"u}r die befragten Rehabilitanden subjektiv bedeutsam waren, gelang die Entwicklung geeigneter Bew{\"a}ltigungsstrategien nur unzureichen}, language = {de} } @article{SalzwedelWegscheiderSchulzBehrendtetal.2019, author = {Salzwedel, Annett and Wegscheider, Karl and Schulz-Behrendt, Claudia and D{\"o}rr, Gesine and Reibis, Rona Katharina and V{\"o}ller, Heinz}, title = {No impact of an extensive social intervention program on return to work and quality of life after acute cardiac event: a cluster-randomized trial in patients with negative occupational prognosis}, series = {International archives of occupational and environmental health}, volume = {92}, journal = {International archives of occupational and environmental health}, number = {8}, publisher = {Springer}, address = {New York}, issn = {0340-0131}, doi = {10.1007/s00420-019-01450-3}, pages = {1109 -- 1120}, year = {2019}, abstract = {Objectives To examine the effectiveness of extensive social therapy intervention during inpatient multi-component cardiac rehabilitation (CR) on return to work and quality of life in patients with low probability of work resumption after an acute cardiac event. Methods Patients after acute cardiac event with negative subjective expectations about return to work or unemployment (n = 354) were included and randomized in clusters of 3-6 study participants. Clusters were randomized for social counseling and therapy led by a social worker, six sessions of 60 min each in 3 weeks, or control group (usual care: individual counseling meeting by request). The return to work (RTW) status and change in quality of life (QoL, short form 12: Physical and Mental Component Summary PCS and MCS) 12 months after discharge from inpatient CR were outcome measures. Results The regression model for RTW showed no impact of the intervention (OR 1.1, 95\% CI 0.6-2.1, P = 0.79; n = 263). Predictors were unemployment prior to CR as well as higher anxiety values at discharge from CR. Likewise, QoL was not improved by social therapy (linear mixed model: Delta PCS 0.3, 95\% CI - 1.9 to 2.5; P = 0.77; n = 177; Delta MCS 0.7, 95\% CI - 1.9 to 3.3; P = 0.58; n = 215). Conclusions In comparison to usual care, an intensive program of social support for patients during inpatient cardiac rehabilitation after an acute cardiac event had no additional impact on either the rate of resuming work or quality of life.}, language = {en} } @article{SalzwedelWegscheiderHerichetal.2015, author = {Salzwedel, Annett and Wegscheider, Karl and Herich, Lena and Rieck, Angelika and Strandt, Gert and V{\"o}ller, Heinz}, title = {Impact of clinical and sociodemographic patient characteristics on the outcome of cardiac rehabilitation in older patients}, series = {Aging clinical and experimental research}, volume = {27}, journal = {Aging clinical and experimental research}, number = {3}, publisher = {Springer}, address = {New York}, issn = {1594-0667}, doi = {10.1007/s40520-014-0283-2}, pages = {315 -- 321}, year = {2015}, abstract = {Background Cardiac rehabilitation (CR) seeks to simultaneously improve several outcome parameters related to patient risk factors, exercise capacity and subjective health. A single score, the multiple outcome criterion (MOC), comprised of alterations in 13 outcome variables was used to measure the overall success of CR in an older population. As this success depends on the older patient's characteristics at the time of admission to CR, we attempted to determine the most important influences. Methods The impact of baseline characteristics on the success of CR, measured by MOC, was analysed using a mixed model for 1,220 older patients (70.9 +/- A 7.0 years, 78.3 \% men) who enrolled in 12 CR clinics. A multitude of potentially influential baseline patient characteristics was considered including sociodemographic variables, comorbidity, duration of hospital stay, exercise capacity, cardiovascular risk factors, emotional status, and laboratory and echocardiographic data. Results Overall, CR was successful, as indicated by the mean value of the MOC (0.6 +/- A 0.45; min -1.0, max 2.0; positive values denoting improvement, negative ones deterioration). Examples of association with negative MOC values included smoking (MOC -0.15, p < 0.001), female gender (MOC -0.07, p = 0.049), and a longer hospital stay (MOC -0.03, p = 0.03). An example of association with positive MOC value was depression score (MOC 0.06, p = 0.003). Further associations included maximal exercise capacity, blood pressure, heart rate and the rehabilitation centre attended. Conclusion Our results emphasize the necessity to take into consideration baseline characteristics when evaluating the success of CR and setting treatment targets for older patients.}, language = {en} } @article{SalzwedelVoeller2021, author = {Salzwedel, Annett and V{\"o}ller, Heinz}, title = {Cardiac rehabilitation}, series = {Deutsches {\"A}rzteblatt international : a weekly online journal of clinical medicine and public health}, volume = {118}, journal = {Deutsches {\"A}rzteblatt international : a weekly online journal of clinical medicine and public health}, number = {29-30}, publisher = {Dt. {\"A}rzte-Verl.}, address = {Cologne}, organization = {OutCaRe Investigators}, issn = {1866-0452}, doi = {10.3238/arztebl.m2021.0211}, pages = {505 -- 506}, year = {2021}, language = {en} } @article{SalzwedelVoellerReibisetal.2018, author = {Salzwedel, Annett and Voeller, Heinz and Reibis, Robert and Bonaventura, Klaus and Behrens, Steffen and Reibis, Rona Katharina}, title = {Regionale Versorgungsaspekte des akuten Myokardinfarktes im Nordosten Deutschlands}, series = {Deutsche medizinische Wochenschrift : DMW ; Organ der Deutschen Gesellschaft f{\"u}r Innere Medizin (DGIM) ; Organ der Gesellschaft Deutscher Naturforscher und {\"A}rzte (GDN{\"A})}, volume = {143}, journal = {Deutsche medizinische Wochenschrift : DMW ; Organ der Deutschen Gesellschaft f{\"u}r Innere Medizin (DGIM) ; Organ der Gesellschaft Deutscher Naturforscher und {\"A}rzte (GDN{\"A})}, number = {8}, publisher = {Thieme}, address = {Stuttgart}, issn = {0012-0472}, doi = {10.1055/s-0043-123907}, pages = {E51 -- E58}, year = {2018}, abstract = {Background In recent decades, guideline-based therapy of myocardial infarction has led to a considerable reduction in myocardial infarction mortality. However, there are relevant differences in acute care and the extent of infarction mortality. The objective of this survey was to analyze the current care situation of patients with acute myocardial infarction in the region of northeast Germany (Berlin, Brandenburg and Mecklenburg-Vorpommern). Methods Based on pseudonymized data from a statutory health insurance of 1 387 084 persons, a total of 6733 patients with inpatient admission at MI were filtered using the ICD10 code I21 and I22 for 2012. Total inhospital mortality and 1-year mortality and prognostic parameters were evaluated and analyzed in country comparisons. Results Both the hospital mortality rate and the 1-year mortality rate of the individual countries (Berlin 13.6 resp. 27.5 \%, respectively, BRB 13.9 and 27.9 \%, MV 14.4 and 29.0 \%, respectively) were comparable to the overall rate (13.9 \% or 28.0 \%) and in the country comparison. In the multiple analysis, the 1-year mortality was determined by the invasive strategy (OR 0.42, 95 \% CI 0.35 -0.51, p < 0.001) as well as by the implementation of the guidelines-based secondary prevention (OR 0.14, 95 \% CI 0.12 - 0.17, p < 0.001). There were no statistical differences between the three federal states. Conclusion The investigated population of patients with acute MI in Berlin, Brandenburg and Mecklenburg-Vorpommern demonstrated a comparable inpatient and post-hospital care and 1-year prognosis regardless of the federal state assignment. Referral to coronary angiography and adequate implementation of evidence-based medication demonstrated a significant prognostic impact.}, language = {de} } @article{SalzwedelRieckReibisetal.2015, author = {Salzwedel, Annett and Rieck, Angelika and Reibis, Rona Katharina and V{\"o}ller, Heinz}, title = {Routine initial exercise stress testing for treatment stratification in comprehensive cardiac rehabilitation}, series = {International journal of rehabilitation research}, volume = {38}, journal = {International journal of rehabilitation research}, number = {4}, publisher = {Lippincott Williams \& Wilkins}, address = {Philadelphia}, issn = {0342-5282}, doi = {10.1097/MRR.0000000000000133}, pages = {344 -- 349}, year = {2015}, abstract = {There is evidence of substantial benefit of cardiac rehabilitation (CR) for patients with low exercise capacity at admission. Nevertheless, some patients are not able to perform an initial exercise stress test (EST). We aimed to describe this group using data of 1094 consecutive patients after a cardiac event (71 +/- 7 years, 78\% men) enrolled in nine centres for inpatient CR. We analysed sociodemographic and clinical variables (e.g. cardiovascular risk factors, comorbidities, complications at admission), amount of therapy (e.g. exercise training, nursing care) and the results of the initial and the final 6-min walking test (6MWT) with respect to the application of an EST. Fifteen per cent of patients did not undergo an EST (non-EST group). In multivariable analysis, the probability of obtaining an EST was higher for men [odds ratio (OR) 1.89, P=0.01], a 6MWT (per 10 m, OR 1.07, P<0.01) and lower for patients with diabetes mellitus (OR 0.48, P<0.01), NYHA-class III/IV (OR 0.27, P<0.01), osteoarthritis (OR 0.39, P<0.01) and a longer hospital stay (per 5 days, OR 0.87, P=0.02). The non-EST group received fewer therapy units of exercise training, but more units of nursing care and physiotherapy than the EST group. However, there were no significant differences between both groups in the increase of the 6MWT during CR (123 vs. 108 m, P=0.122). The present study confirms the feasibility of an EST at the start of CR as an indicator of disease severity. Nevertheless, patients without EST benefit from CR even if exercising less. Thus, there is a justified need for individualized, comprehensive and interdisciplinary CR.}, language = {en} } @article{SalzwedelReibisWegscheideretal.2016, author = {Salzwedel, Annett and Reibis, Rona Katharina and Wegscheider, Karl and Eichler, Sarah and Buhlert, Hermann and Kaminski, Stefan and V{\"o}ller, Heinz}, title = {Cardiopulmonary exercise testing is predictive of return to work in cardiac patients after multicomponent rehabilitation}, series = {Clinical research in cardiology : official journal of the German Cardiac Society.}, volume = {105}, journal = {Clinical research in cardiology : official journal of the German Cardiac Society.}, publisher = {Springer}, address = {Heidelberg}, issn = {1861-0684}, doi = {10.1007/s00392-015-0917-1}, pages = {257 -- 267}, year = {2016}, abstract = {Return to work (RTW) is a pivotal goal of cardiac rehabilitation (CR) in patients after acute cardiac event. We aimed to evaluate cardiopulmonary exercise testing (CPX) parameters as predictors for RTW at discharge after CR. We analyzed data from a registry of 489 working-age patients (51.5 +/- A 6.9 years, 87.9 \% men) who had undergone inpatient CR predominantly after percutaneous coronary intervention (PCI 62.6 \%), coronary artery bypass graft (CABG 17.2 \%), or heart valve replacement (9.0 \%). Sociodemographic and clinical parameters, noninvasive cardiac diagnostic (2D echo, exercise ECG, 6MWT) and psychodiagnostic screening data, as well as CPX findings, were merged with RTW data from the German statutory pension insurance program and analyzed for prognostic ability. During a mean follow-up of 26.5 +/- A 11.9 months, 373 (76.3 \%) patients returned to work, 116 (23.7 \%) did not, and 60 (12.3 \%) retired. After adjustment for covariates, elective CABG (HR 0.68, 95 \% CI 0.47-0.98; p = 0.036) and work intensity (per level HR 0.83, 95 \% CI 0.73-0.93; p = 0.002) were negatively associated with the probability of RTW. Exercise capacity in CPX (in Watts) and the VE/VCO2-slope had independent prognostic significance for RTW. A higher work load increased (HR 1.17, 95 \% CI 1.02-1.35; p = 0.028) the probability of RTW, while a higher VE/VCO2 slope decreased (HR 0.85, 95 \% CI 0.76-0.96; p = 0.009) it. CPX also had prognostic value for retirement: the likelihood of retirement decreased with increasing exercise capacity (HR 0.50, 95 \% CI 0.30-0.82; p = 0.006).}, language = {en} } @article{SalzwedelReibisHeidleretal.2019, author = {Salzwedel, Annett and Reibis, Rona Katharina and Heidler, Maria-Dorothea and Wegscheider, Karl and V{\"o}ller, Heinz}, title = {Determinants of Return to Work After Multicomponent Cardiac Rehabilitation}, series = {Archives of Physical Medicine and Rehabilitation}, volume = {100}, journal = {Archives of Physical Medicine and Rehabilitation}, number = {12}, publisher = {Elsevier}, address = {Philadelphia}, issn = {0003-9993}, doi = {10.1016/j.apmr.2019.04.003}, pages = {2399 -- 2402}, year = {2019}, abstract = {Objectives: To explore predictors of return to work in patients after acute coronary syndrome and coronary artery bypass grafting, taking into account cognitive performance, depression, physical capacity, and self-assessment of the occupational prognosis. Design: Observational, prospective, bicentric. Setting: Postacute 3-week inpatient cardiac rehabilitation (CR). Participants: Patients (N=401) <65 years of age (mean 54.5 +/- 6.3y), 80\% men. Interventions: Not applicable. Main Outcome Measures: Status of return to work (RTW) 6 months after discharge from CR. Results: The regression model for RTW showed negative associations for depression (odds ratio 0.52 per SD, 95\% confidence interval 0.36-0.76, P=.001), age (odds ratio 0.72, 95\% confidence interval 0.52-1.00, P=.047), and in particular for a negative subjective occupational prognosis (expected incapacity for work odds ratio 0.19, 95\% confidence interval 0.06-0.59, P=.004; unemployment odds ratio 0.08, 95\% confidence interval 0.01-0.72, P=.024; retirement odds ratio 0.07, 95\% confidence interval 0.01-0.067, P=.021). Positive predictors were employment before the cardiac event (odds ratio 9.66, 95\% confidence interval 3.10-30.12, P<.001), capacity to work (fit vs unfit) at discharge from CR (odds ratio 3.15, 95\% confidence interval 1.35-7.35, P=.008), and maximum exercise capacity (odds ratio 1.49, 95\% confidence interval 1.06-2.11, P=.022). Cognitive performance had no effect.}, language = {en} } @article{SalzwedelReibisHadzicetal.2019, author = {Salzwedel, Annett and Reibis, Rona Katharina and Hadzic, Miralem and Buhlert, Hermann and V{\"o}ller, Heinz}, title = {Patients' expectations of returning to work, co-morbid disorders and work capacity at discharge from cardiac rehabilitation}, series = {Vascular Health and Risk Management}, volume = {15}, journal = {Vascular Health and Risk Management}, publisher = {Dove Medical Press}, address = {Albany, Auckland}, issn = {1176-6344}, doi = {10.2147/VHRM.S216039}, pages = {301 -- 308}, year = {2019}, abstract = {Objective: We aimed to characterize patients after an acute cardiac event regarding their negative expectations around returning to work and the impact on work capacity upon discharge from cardiac rehabilitation (CR). Methods: We analyzed routine data of 884 patients (52±7 years, 76\% men) who attended 3 weeks of inpatient CR after an acute coronary syndrome (ACS) or cardiac surgery between October 2013 and March 2015. The primary outcome was their status determining their capacity to work (fit vs unfit) at discharge from CR. Further, sociodemographic data (eg, age, sex, and education level), diagnoses, functional data (eg, exercise stress test and 6-min walking test [6MWT]), the Hospital Anxiety and Depression Scale (HADS) and self-assessment of the occupational prognosis (negative expectations and/or unemployment, W{\"u}rzburger screening) at admission to CR were considered. Results: A negative occupational prognosis was detected in 384 patients (43\%). Out of these, 368 (96\%) expected not to return to work after CR and/or were unemployed before CR at 29\% (n=113). Affected patients showed a reduced exercise capacity (bicycle stress test: 100 W vs 118 W, P<0.01; 6MWT: 380 m vs 421 m, P<0.01) and were more likely to receive a depression diagnosis (12\% vs 3\%, P<0.01), as well as higher levels on the HADS. At discharge from CR, 21\% of this group (n=81) were fit for work (vs 35\% of patients with a normal occupational prognosis (n=175, P<0.01)). Sick leave before the cardiac event (OR 0.4, 95\% CI 0.2-0.6, P<0.01), negative occupational expectations (OR 0.4, 95\% CI 0.3-0.7, P<0.01) and depression (OR 0.3, 95\% CI 0.1-0.8, P=0.01) reduced the likelihood of achieving work capacity upon discharge. In contrast, higher exercise capacity was positively associated. Conclusion: Patients with a negative occupational prognosis often revealed a reduced physical performance and suffered from a high psychosocial burden. In addition, patients' occupational expectations were a predictor of work capacity at discharge from CR. Affected patients should be identified at admission to allow for targeted psychosocial care.}, language = {en} } @article{SalzwedelRabeZahnetal.2018, author = {Salzwedel, Annett and Rabe, Sophie and Zahn, Thomas and Neuwirth, Julia and Eichler, Sarah and Haubold, Kathrin and Wachholz, Anne and Reibis, Rona Katharina and V{\"o}ller, Heinz}, title = {Nutzerinteresse an mobilen digitalen Assistenzsystemen zur F{\"o}rderung k{\"o}rperlicher Aktivit{\"a}t bei Studierenden und Mitarbeitern einer Universit{\"a}t}, series = {Gesundheitswesen}, volume = {80}, journal = {Gesundheitswesen}, number = {11}, publisher = {Thieme}, address = {Stuttgart}, issn = {0941-3790}, doi = {10.1055/s-0043-103951}, pages = {1023 -- 1025}, year = {2018}, abstract = {Hintergrund Einem Großteil der Bev{\"o}lkerung gelingt es trotz ausreichenden Wissens um die protektiven Effekte nicht, ausreichende k{\"o}rperliche Aktivit{\"a}t in den Alltag zu integrieren. Digitale Assistenzsysteme k{\"o}nnten hierbei unterst{\"u}tzend eingesetzt werden. Dies setzt jedoch das Interesse potentieller Nutzer voraus. Methode In einer Online-Befragung wurden im Juni/Juli 2015 Mitarbeiter und Studierende der Universit{\"a}t Potsdam zum individuellen Ausmaß der sportlichen Aktivit{\"a}t, dem Interesse an elektronischer Trainingsunterst{\"u}tzung und weiteren Parametern befragt. Ergebnis 1217 Studierende und 485 Mitarbeiter (67,3 bzw. 67,5\% Frauen, 26±4,9 bzw. 42,7±11,7 Jahre) nahmen an der Studie teil. Die empfohlene sportliche Aktivit{\"a}t (≥3 Tage bzw. 150 min/Woche) wurde von 70,1\% der Mitarbeiter und 52,7\% der Studierenden nicht erreicht. Innerhalb dieser Gruppen zeigten 53,2\% (Studierende) bzw. 44,2\% (Mitarbeiter), unabh{\"a}ngig von Alter, Geschlecht, BMI bzw. Bildungsniveau, Interesse an einer elektronischen Trainingsunterst{\"u}tzung. Schlussfolgerung Auch in j{\"u}ngeren Bev{\"o}lkerungsgruppen mit hohem Bildungsniveau ist die Mehrzahl der Personen unzureichend k{\"o}rperlich aktiv. Ein Interesse an Trainingsunterst{\"u}tzung besteht in etwa der H{\"a}lfte dieser sportlich inaktiven Gruppe. Dies legt den Schluss nahe, dass der personalisierte Einsatz mobiler Assistenzsysteme f{\"u}r die positive Beeinflussung des Lebensstils zunehmend an Bedeutung gewinnen k{\"o}nnte.}, language = {de} } @article{SalzwedelRabeZahnetal.2017, author = {Salzwedel, Annett and Rabe, Sophie and Zahn, Thomas and Neuwirth, Julia and Eichler, Sarah and Haubold, Kathrin and Wachholz, Anne and Reibis, Rona Katharina and V{\"o}ller, Heinz}, title = {User Interest in Digital Health Technologies to Encourage Physical Activity}, series = {JMIR. Mhealth \& Uhealth}, volume = {5}, journal = {JMIR. Mhealth \& Uhealth}, number = {4}, publisher = {JMIR Publications}, address = {Toronto}, doi = {10.2196/mhealth.7192}, year = {2017}, abstract = {Background: Although the benefits for health of physical activity (PA) are well documented, the majority of the population is unable to implement present recommendations into daily routine. Mobile health (mHealth) apps could help increase the level of PA. However, this is contingent on the interest of potential users. Objective: The aim of this study was the explorative, nuanced determination of the interest in mHealth apps with respect to PA among students and staff of a university. Methods: We conducted a Web-based survey from June to July 2015 in which students and employees from the University of Potsdam were asked about their activity level, interest in mHealth fitness apps, chronic diseases, and sociodemographic parameters. Results: A total of 1217 students (67.30\%, 819/1217; female; 26.0 years [SD 4.9]) and 485 employees (67.5\%, 327/485; female; 42.7 years [SD 11.7]) participated in the survey. The recommendation for PA (3 times per week) was not met by 70.1\% (340/485) of employees and 52.67\% (641/1217) of students. Within these groups, 53.2\% (341/641 students) and 44.2\% (150/340 employees)—independent of age, sex, body mass index (BMI), and level of education or professional qualification—indicated an interest in mHealth fitness apps. Conclusions: Even in a younger, highly educated population, the majority of respondents reported an insufficient level of PA. About half of them indicated their interest in training support. This suggests that the use of personalized mobile fitness apps may become increasingly significant for a positive change of lifestyle.}, language = {en} } @article{SalzwedelNosperRoehrigetal.2014, author = {Salzwedel, Annett and Nosper, Manfred and Roehrig, Bernd and Linck-Eleftheriadis, Sigrid and Strandt, Gert and V{\"o}ller, Heinz}, title = {Outcome quality of in-patient cardiac rehabilitation in elderly patients - identification of relevant parameters}, series = {European journal of preventive cardiology : the official ESC journal for primary \& secondary cardiovascular prevention, rehabilitation and sports cardiology}, volume = {21}, journal = {European journal of preventive cardiology : the official ESC journal for primary \& secondary cardiovascular prevention, rehabilitation and sports cardiology}, number = {2}, publisher = {Sage Publ.}, address = {London}, issn = {2047-4873}, doi = {10.1177/2047487312469475}, pages = {172 -- 180}, year = {2014}, abstract = {Background: Outcome quality management requires the consecutive registration of defined variables. The aim was to identify relevant parameters in order to objectively assess the in-patient rehabilitation outcome. Methods: From February 2009 to June 2010 1253 patients (70.9 +/- 7.0 years, 78.1\% men) at 12 rehabilitation clinics were enrolled. Items concerning sociodemographic data, the impairment group (surgery, conservative/interventional treatment), cardiovascular risk factors, structural and functional parameters and subjective health were tested in respect of their measurability, sensitivity to change and their propensity to be influenced by rehabilitation. Results: The majority of patients (61.1\%) were referred for rehabilitation after cardiac surgery, 38.9\% after conservative or interventional treatment for an acute coronary syndrome. Functionally relevant comorbidities were seen in 49.2\% (diabetes mellitus, stroke, peripheral artery disease, chronic obstructive lung disease). In three key areas 13 parameters were identified as being sensitive to change and subject to modification by rehabilitation: cardiovascular risk factors (blood pressure, low-density lipoprotein cholesterol, triglycerides), exercise capacity (resting heart rate, maximal exercise capacity, maximal walking distance, heart failure, angina pectoris) and subjective health (IRES-24 (indicators of rehabilitation status): pain, somatic health, psychological well-being and depression as well as anxiety on the Hospital Anxiety and Depression Scale). Conclusion: The outcome of in-patient rehabilitation in elderly patients can be comprehensively assessed by the identification of appropriate key areas, that is, cardiovascular risk factors, exercise capacity and subjective health. This may well serve as a benchmark for internal and external quality management.}, language = {en} } @article{SalzwedelKoranLangheimetal.2020, author = {Salzwedel, Annett and Koran, Iryna and Langheim, Eike and Schlitt, Axel and Nothroff, J{\"o}rg and Bongarth, Christa and Wrenger, Markus and Sehner, Susanne and Reibis, Rona Katharina and Wegscheider, Karl and V{\"o}ller, Heinz}, title = {Patient-reported outcomes predict return to work and health-related quality of life six months after cardiac rehabilitation}, series = {PLoS ONE}, volume = {15}, journal = {PLoS ONE}, number = {5}, publisher = {Plos 1}, address = {San Francisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0232752}, pages = {17}, year = {2020}, abstract = {Background Multi-component cardiac rehabilitation (CR) is performed to achieve an improved prognosis, superior health-related quality of life (HRQL) and occupational resumption through the management of cardiovascular risk factors, as well as improvement of physical performance and patients' subjective health. Out of a multitude of variables gathered at CR admission and discharge, we aimed to identify predictors of returning to work (RTW) and HRQL 6 months after CR. Design Prospective observational multi-centre study, enrolment in CR between 05/2017 and 05/2018. Method Besides general data (e.g. age, sex, diagnoses), parameters of risk factor management (e.g. smoking, hypertension), physical performance (e.g. maximum exercise capacity, endurance training load, 6-min walking distance) and patient-reported outcome measures (e.g. depression, anxiety, HRQL, subjective well-being, somatic and mental health, pain, lifestyle change motivation, general self-efficacy, pension desire and self-assessment of the occupational prognosis using several questionnaires) were documented at CR admission and discharge. These variables (at both measurement times and as changes during CR) were analysed using multiple linear regression models regarding their predictive value for RTW status and HRQL (SF-12) six months after CR. Results Out of 1262 patients (54±7 years, 77\% men), 864 patients (69\%) returned to work. Predictors of failed RTW were primarily the desire to receive pension (OR = 0.33, 95\% CI: 0.22-0.50) and negative self-assessed occupational prognosis (OR = 0.34, 95\% CI: 0.24-0.48) at CR discharge, acute coronary syndrome (OR = 0.64, 95\% CI: 0.47-0.88) and comorbid heart failure (OR = 0.51, 95\% CI: 0.30-0.87). High educational level, stress at work and physical and mental HRQL were associated with successful RTW. HRQL was determined predominantly by patient-reported outcome measures (e.g. pension desire, self-assessed health prognosis, anxiety, physical/mental HRQL/health, stress, well-being and self-efficacy) rather than by clinical parameters or physical performance. Conclusion Patient-reported outcome measures predominantly influenced return to work and HRQL in patients with heart disease. Therefore, the multi-component CR approach focussing on psychosocial support is crucial for subjective health prognosis and occupational resumption.}, language = {en} } @article{SalzwedelJensenRauchetal.2020, author = {Salzwedel, Annett and Jensen, Katrin and Rauch, Bernhard and Doherty, Patrick and Metzendorf, Maria-Inti and Hackbusch, Matthes and V{\"o}ller, Heinz and Schmid, Jean-Paul and Davos, Constantinos H.}, title = {Effectiveness of comprehensive cardiac rehabilitation in coronary artery disease patients treated according to contemporary evidence based medicine}, series = {European journal of preventive cardiology : the official ESC journal for primary \& secondary cardiovascular prevention, rehabilitation and sports cardiology}, volume = {27}, journal = {European journal of preventive cardiology : the official ESC journal for primary \& secondary cardiovascular prevention, rehabilitation and sports cardiology}, number = {16}, publisher = {Oxford Univ. Press}, address = {Oxford}, organization = {Univ Heidelberg Heinrich Heine Univ}, issn = {2047-4873}, doi = {10.1177/2047487320905719}, pages = {1756 -- 1774}, year = {2020}, abstract = {Background Despite numerous studies and meta-analyses the prognostic effect of cardiac rehabilitation is still under debate. This update of the Cardiac Rehabilitation Outcome Study (CROS II) provides a contemporary and practice focused approach including only cardiac rehabilitation interventions based on published standards and core components to evaluate cardiac rehabilitation delivery and effectiveness in improving patient prognosis. Design A systematic review and meta-analysis. Methods Randomised controlled trials and retrospective and prospective controlled cohort studies evaluating patients after acute coronary syndrome, coronary artery bypass grafting or mixed populations with coronary artery disease published until September 2018 were included. Resulte Based on CROS inclusion criteria out of 7096 abstracts six additional studies including 8671 patients were identified (two randomised controlled trials, two retrospective controlled cohort studies, two prospective controlled cohort studies). In total, 31 studies including 228,337 patients were available for this meta-analysis (three randomised controlled trials, nine prospective controlled cohort studies, 19 retrospective controlled cohort studies; 50,653 patients after acute coronary syndrome 14,583, after coronary artery bypass grafting 163,101, mixed coronary artery disease populations; follow-up periods ranging from 9 months to 14 years). Heterogeneity in design, cardiac rehabilitation delivery, biometrical assessment and potential confounders was considerable. Controlled cohort studies showed a significantly reduced total mortality (primary endpoint) after cardiac rehabilitation participation in patients after acute coronary syndrome (prospective controlled cohort studies: hazard ratio (HR) 0.37, 95\% confidence interval (CI) 0.20-0.69; retrospective controlled cohort studies HR 0.64, 95\% CI 0.53-0.76; prospective controlled cohort studies odds ratio 0.20, 95\% CI 0.08-0.48), but the single randomised controlled trial fulfilling the CROS inclusion criteria showed neutral results. Cardiac rehabilitation participation was also associated with reduced total mortality in patients after coronary artery bypass grafting (retrospective controlled cohort studies HR 0.62, 95\% CI 0.54-0.70, one single randomised controlled trial without fatal events), and in mixed coronary artery disease populations (retrospective controlled cohort studies HR 0.52, 95\% CI 0.36-0.77; two out of 10 controlled cohort studies with neutral results). Conclusion CROS II confirms the effectiveness of cardiac rehabilitation participation after acute coronary syndrome and after coronary artery bypass grafting in actual clinical practice by reducing total mortality under the conditions of current evidence-based coronary artery disease treatment. The data of CROS II, however, underscore the urgent need to define internationally accepted minimal standards for cardiac rehabilitation delivery as well as for scientific evaluation.}, language = {en} } @article{SalzwedelHeidlerMengetal.2020, author = {Salzwedel, Annett and Heidler, Maria-Dorothea and Meng, Karin and Schikora, Martin and Wegscheider, Karl and Reibis, Rona Katharina and V{\"o}ller, Heinz}, title = {Impact of cognitive performance on disease-related knowledge six months after multi-component rehabilitation in patients after an acute cardiac event}, series = {European journal of preventive cardiology : the official ESC journal for primary \& secondary cardiovascular prevention, rehabilitation and sports cardiology}, volume = {26}, journal = {European journal of preventive cardiology : the official ESC journal for primary \& secondary cardiovascular prevention, rehabilitation and sports cardiology}, number = {1}, publisher = {Sage Publ.}, address = {London}, issn = {2047-4873}, doi = {10.1177/2047487318791609}, pages = {46 -- 55}, year = {2020}, abstract = {Background Although associations between cardiovascular diseases and cognitive impairment are well known, the impact of cognitive performance on the success of patient education as a core component of cardiac rehabilitation remains insufficiently investigated so far. Design Prospective observational study in two inpatient cardiac rehabilitation centres between September 2014 and August 2015 with a follow-up six months after cardiac rehabilitation. Method At admission to and discharge from cardiac rehabilitation, the cognitive performance of 401 patients (54.5 ± 6.3 years, 80\% men) following an acute coronary syndrome and/or coronary artery bypass graft was tested using the Montreal Cognitive Assessment. Patients' disease-related knowledge was determined using a quiz (22 items for medical knowledge and 12 items for healthy lifestyle and behaviour) at both times and at follow-up. The change in knowledge after cardiac rehabilitation was analysed in multivariable regression models. Potentially influencing parameters (e.g. level of education, medication, cardiovascular risk factors, coronary artery bypass graft, comorbidities, exercise capacity) were considered. Results During cardiac rehabilitation, disease-related knowledge was significantly enhanced in both scales. At follow-up, the average level of medical knowledge was significantly reduced, while lifestyle knowledge remained at a stable level. The maintenance of knowledge after cardiac rehabilitation was predominantly predicted by prior knowledge, cognitive performance at discharge from cardiac rehabilitation and, in the case of medical knowledge, by coronary artery bypass graft. Conclusion Patient education in cardiac rehabilitation led to enhanced disease-related knowledge, but the maintenance of this essentially depended on patients' cognitive performance, especially after coronary artery bypass graft. Therefore, patient education concepts in cardiac rehabilitation should be reconsidered and adjusted as needed.}, language = {en} } @article{SalzwedelHeidlerHauboldetal.2017, author = {Salzwedel, Annett and Heidler, Maria-Dorothea and Haubold, Kathrin and Schikora, Martin and Reibis, Rona Katharina and Wegscheider, Karl and J{\"o}bgens, Michael and V{\"o}ller, Heinz}, title = {Prevalence of mild cognitive impairment in employable patients after acute coronary event in cardiac rehabilitation}, series = {Vascular Health and Risk Management}, volume = {13}, journal = {Vascular Health and Risk Management}, publisher = {Dove Medical Press Ltd}, address = {Albany, Auckland}, issn = {1176-6344}, doi = {10.2147/VHRM.S121086}, pages = {55 -- 60}, year = {2017}, abstract = {Introduction: Adequate cognitive function in patients is a prerequisite for successful implementation of patient education and lifestyle coping in comprehensive cardiac rehabilitation (CR) programs. Although the association between cardiovascular diseases and cognitive impairments (CIs) is well known, the prevalence particularly of mild CI in CR and the characteristics of affected patients have been insufficiently investigated so far. Methods: In this prospective observational study, 496 patients (54.5 ± 6.2 years, 79.8\% men) with coronary artery disease following an acute coronary event (ACE) were analyzed. Patients were enrolled within 14 days of discharge from the hospital in a 3-week inpatient CR program. Patients were tested for CI using the Montreal Cognitive Assessment (MoCA) upon admission to and discharge from CR. Additionally, sociodemographic, clinical, and physiological variables were documented. The data were analyzed descriptively and in a multivariate stepwise backward elimination regression model with respect to CI. Results: At admission to CR, the CI (MoCA score < 26) was determined in 182 patients (36.7\%). Significant differences between CI and no CI groups were identified, and CI group was associated with high prevalence of smoking (65.9 vs 56.7\%, P = 0.046), heavy (physically demanding) workloads (26.4 vs 17.8\%, P < 0.001), sick leave longer than 1 month prior to CR (28.6 vs 18.5\%, P = 0.026), reduced exercise capacity (102.5 vs 118.8 W, P = 0.006), and a shorter 6-min walking distance (401.7 vs 421.3 m, P = 0.021) compared to no CI group. The age- and education-adjusted model showed positive associations with CI only for sick leave more than 1 month prior to ACE (odds ratio [OR] 1.673, 95\% confidence interval 1.07-2.79; P = 0.03) and heavy workloads (OR 2.18, 95\% confidence interval 1.42-3.36; P < 0.01). Conclusion: The prevalence of CI in CR was considerably high, affecting more than one-third of cardiac patients. Besides age and education level, CI was associated with heavy workloads and a longer sick leave before ACE.}, language = {en} } @article{SalzwedelHauboldBarnacketal.2018, author = {Salzwedel, Annett and Haubold, Kathrin and Barnack, Beate and Reibis, Rona Katharina and V{\"o}ller, Heinz}, title = {Indikatoren der Ergebnisqualit{\"a}t kardiologischer Rehabilitation Ergebnisse einer Delphi-Befragung von Mitgliedern der Deutschen Gesellschaft f{\"u}r Pr{\"a}vention und Rehabilitation von Herz- und Kreislauferkrankungen e. V. (DGPR)}, series = {Die Rehabilitation : Zeitschrift f{\"u}r Praxis und Forschung in der Rehabilitation}, volume = {58}, journal = {Die Rehabilitation : Zeitschrift f{\"u}r Praxis und Forschung in der Rehabilitation}, number = {1}, publisher = {Thieme}, address = {Stuttgart}, issn = {0034-3536}, doi = {10.1055/s-0044-101048}, pages = {31 -- 38}, year = {2018}, abstract = {Ziel der Studie Die vorliegende Untersuchung beinhaltete die explorative Erfassung potenzieller Indikatoren der Ergebnisqualit{\"a}t der kardiologischen Rehabilitation (CR) f{\"u}r Patienten unter 65 Jahren. Methoden In einer 4-stufigen webbasierten Delphi-Befragung (04-07/2016) von in der CR t{\"a}tigen {\"A}rzten[2] , Psychologen und Sport-/Physiotherapeuten wurden Parameter der k{\"o}rperlichen Leistungsf{\"a}higkeit, der Sozialmedizin, der subjektiven Gesundheit und kardiovaskul{\"a}re Risikofaktoren hinsichtlich ihrer Eignung als Qualit{\"a}tsindikator bewertet. Ergebnisse Von 44 vorgegebenen wie auch von den Teilnehmern vorgeschlagenen Parametern wurden 21 Parameter (48\%), die H{\"a}lfte davon psychosoziale Faktoren, als potenzielle Qualit{\"a}tsindikatoren ausgew{\"a}hlt, wobei lediglich f{\"u}r das Rauchverhalten, den Blutdruck, das LDL-Cholesterin und die max. Belastbarkeit im Belastungs-EKG ein Konsens (Zustimmung>75\% der Befragten) erzielt wurde. Schlussfolgerung Die Wahl der Qualit{\"a}tsindikatoren durch die Experten erfolgte mehrheitlich mit nur geringer Einigkeit. Eine klinische und wissenschaftliche Evaluierung der gew{\"a}hlten Parameter ist daher zwingend erforderlich.}, language = {de} } @article{RoehrigSalzwedelLinckEleftheriadisetal.2015, author = {R{\"o}hrig, Bernd and Salzwedel, Annett and Linck-Eleftheriadis, Sigrid and V{\"o}ller, Heinz and Nosper, Manfred}, title = {Outcome Based Center Comparisons in Inpatient Cardiac Rehabilitation Results from the EVA-Reha (R) Cardiology Project}, series = {Die Rehabilitation : Zeitschrift f{\"u}r Praxis und Forschung in der Rehabilitation}, volume = {54}, journal = {Die Rehabilitation : Zeitschrift f{\"u}r Praxis und Forschung in der Rehabilitation}, number = {1}, publisher = {Thieme}, address = {Stuttgart}, issn = {0034-3536}, doi = {10.1055/s-0034-1395556}, pages = {45 -- 52}, year = {2015}, abstract = {Background: So far, for center comparisons in inpatient cardiac rehabilitation (CR), the objective outcome quality was neglected because of challenges in quantifying the overall success of CR. In this article, a multifactorial benchmark model measuring the individual rehabilitation success is presented. Methods: In 21 rehabilitation centers, 5 123 patients were consecutively enrolled between 01/2010 and 12/2012 in the prospective multicenter registry EVA-Reha (R) Cardiology. Changes in 13 indicators in the areas cardiovascular risk factors, physical performance and subjective health during rehabilitation were evaluated according to levels of severity. Changes were only rated for patients who needed a medical intervention. Additionally, the changes had to be clinically relevant. Therefore Minimal Important Differences (MID) were predefined. Ratings were combined to a single score, the multiple outcome criterion (MEK). Results: The MEK was determined for all patients (71.7 +/- 7.4 years, 76.9 \% men) and consisted of an average of 5.6 indicators. After risk adjustment for sociodemographic and clinical baseline parameters, MEK was used for center ranking. In addition, individual results of indicators were compared with means of all study sites. Conclusion: With the method presented here, the outcome quality can be quantified and outcome-based comparisons of providers can be made.}, language = {de} }