@article{SalamatZoellerZareetal.2018, author = {Salamat, Mona and Z{\"o}ller, Gert and Zare, Mehdi and Amini, Mortaza}, title = {The maximum expected earthquake magnitudes in different future time intervals of six seismotectonic zones of Iran and its surroundings}, series = {Journal of seismology}, volume = {22}, journal = {Journal of seismology}, number = {6}, publisher = {Springer}, address = {Dordrecht}, issn = {1383-4649}, doi = {10.1007/s10950-018-9780-7}, pages = {1485 -- 1498}, year = {2018}, abstract = {One of the crucial components in seismic hazard analysis is the estimation of the maximum earthquake magnitude and associated uncertainty. In the present study, the uncertainty related to the maximum expected magnitude mu is determined in terms of confidence intervals for an imposed level of confidence. Previous work by Salamat et al. (Pure Appl Geophys 174:763-777, 2017) shows the divergence of the confidence interval of the maximum possible magnitude m(max) for high levels of confidence in six seismotectonic zones of Iran. In this work, the maximum expected earthquake magnitude mu is calculated in a predefined finite time interval and imposed level of confidence. For this, we use a conceptual model based on a doubly truncated Gutenberg-Richter law for magnitudes with constant b-value and calculate the posterior distribution of mu for the time interval T-f in future. We assume a stationary Poisson process in time and a Gutenberg-Richter relation for magnitudes. The upper bound of the magnitude confidence interval is calculated for different time intervals of 30, 50, and 100 years and imposed levels of confidence alpha = 0.5, 0.1, 0.05, and 0.01. The posterior distribution of waiting times T-f to the next earthquake with a given magnitude equal to 6.5, 7.0, and7.5 are calculated in each zone. In order to find the influence of declustering, we use the original and declustered version of the catalog. The earthquake catalog of the territory of Iran and surroundings are subdivided into six seismotectonic zones Alborz, Azerbaijan, Central Iran, Zagros, Kopet Dagh, and Makran. We assume the maximum possible magnitude m(max) = 8.5 and calculate the upper bound of the confidence interval of mu in each zone. The results indicate that for short time intervals equal to 30 and 50 years and imposed levels of confidence 1 - alpha = 0.95 and 0.90, the probability distribution of mu is around mu = 7.16-8.23 in all seismic zones.}, language = {en} } @article{AsgarimehrWickertReich2018, author = {Asgarimehr, Milad and Wickert, Jens and Reich, Sebastian}, title = {TDS-1 GNSS Reflectometry}, series = {IEEE journal of selected topics in applied earth observations and remote sensing}, volume = {11}, journal = {IEEE journal of selected topics in applied earth observations and remote sensing}, number = {11}, publisher = {Inst. of Electr. and Electronics Engineers}, address = {Piscataway}, issn = {1939-1404}, doi = {10.1109/JSTARS.2018.2873241}, pages = {4534 -- 4541}, year = {2018}, abstract = {This study presents the development and a systematic evaluation study of GNSS reflectometry wind speeds. After establishing a wind speed retrieval algorithm, UK TechDemoSat-1 (TDS-1) derived winds, from May 2015 to July 2017, are compared to the Advanced Scatterometer (ASCAT). ERA-Interim wind fields of the European Centre for Medium-range Weather Forecasts (ECMWF) and in situ observation from Tropical Atmosphere Ocean buoy array in the Pacific are taken as reference. One-year averaged TDS-1 global winds demonstrate small differences with ECMWF in a majority of areas as well as discuss under- and overestimations. The pioneering TDS-1 winds demonstrate a root-mean-squared error (RMSE) and bias of 2.77 and -0.33 m/s, which are comparable to the RMSE and bias derived by ASCAT winds, as large as 2.31 and 0.25 m/s, respectively. Using buoys measurements as reference, RMSE and bias of 2.23 and -0.03 m/s for TDS-1 as well as 1.40 and -0.68 m/s for ASCAT are obtained. Utilizing rain microwave-infrared estimates of the Tropical Rainfall Measuring Mission, rain-affected observation of both ASCAT and TDS-1 are collected and evaluated. Although ASCAT winds show a significant performance degradation resulting in an RMSE and bias of 3.16 and 1.03 m/s, respectively, during rain condition, TDS-1 shows a more reliable performance with an RMSE and bias of 2.94 and -0.21 m/s, respectively, which indicates the promising capability of GNSS forward scattering for wind retrievals during rain. A decrease in TDS-1-derived bistatic radar cross sections during rain events, at weak winds, is also demonstrated.}, language = {en} } @article{MoeserLorenzSajfutdinowetal.2018, author = {M{\"o}ser, Christin and Lorenz, Jessica S. and Sajfutdinow, Martin and Smith, David M.}, title = {Pinpointed Stimulation of EphA2 Receptors via DNA-Templated Oligovalence}, series = {International journal of molecular sciences}, volume = {19}, journal = {International journal of molecular sciences}, number = {11}, publisher = {MDPI}, address = {Basel}, issn = {1422-0067}, doi = {10.3390/ijms19113482}, pages = {19}, year = {2018}, abstract = {DNA nanostructures enable the attachment of functional molecules to nearly any unique location on their underlying structure. Due to their single-base-pair structural resolution, several ligands can be spatially arranged and closely controlled according to the geometry of their desired target, resulting in optimized binding and/or signaling interactions. Here, the efficacy of SWL, an ephrin-mimicking peptide that binds specifically to EphrinA2 (EphA2) receptors, increased by presenting up to three of these peptides on small DNA nanostructures in an oligovalent manner. Ephrin signaling pathways play crucial roles in tumor development and progression. Moreover, Eph receptors are potential targets in cancer diagnosis and treatment. Here, the quantitative impact of SWL valency on binding, phosphorylation (key player for activation) and phenotype regulation in EphA2-expressing prostate cancer cells was demonstrated. EphA2 phosphorylation was significantly increased by DNA trimers carrying three SWL peptides compared to monovalent SWL. In comparison to one of EphA2's natural ligands ephrin-A1, which is known to bind promiscuously to multiple receptors, pinpointed targeting of EphA2 by oligovalent DNA-SWL constructs showed enhanced cell retraction. Overall, we show that DNA scaffolds can increase the potency of weak signaling peptides through oligovalent presentation and serve as potential tools for examination of complex signaling pathways.}, language = {en} } @article{AfshariMoeinSomogyvariValleyetal.2018, author = {Afshari Moein, Mohammad J. and Somogyv{\´a}ri, M{\´a}rk and Valley, Beno{\^i}t and Jalali, Mohammadreza and L{\"o}w, Simon and Bayer, Peter}, title = {Fracture network characterization using stress-based tomography}, series = {Journal of geophysical research : JGR}, volume = {123}, journal = {Journal of geophysical research : JGR}, number = {11}, publisher = {American Geophysical Union}, address = {Washington}, issn = {2169-9313}, doi = {10.1029/2018JB016438}, pages = {9324 -- 9340}, year = {2018}, abstract = {Information on structural features of a fracture network at early stages of Enhanced Geothermal System development is mostly restricted to borehole images and, if available, outcrop data. However, using this information to image discontinuities in deep reservoirs is difficult. Wellbore failure data provides only some information on components of the in situ stress state and its heterogeneity. Our working hypothesis is that slip on natural fractures primarily controls these stress heterogeneities. Based on this, we introduce stress-based tomography in a Bayesian framework to characterize the fracture network and its heterogeneity in potential Enhanced Geothermal System reservoirs. In this procedure, first a random initial discrete fracture network (DFN) realization is generated based on prior information about the network. The observations needed to calibrate the DFN are based on local variations of the orientation and magnitude of at least one principal stress component along boreholes. A Markov Chain Monte Carlo sequence is employed to update the DFN iteratively by a fracture translation within the domain. The Markov sequence compares the simulated stress profile with the observed stress profiles in the borehole, evaluates each iteration with Metropolis-Hastings acceptance criteria, and stores acceptable DFN realizations in an ensemble. Finally, this obtained ensemble is used to visualize the potential occurrence of fractures in a probability map, indicating possible fracture locations and lengths. We test this methodology to reconstruct simple synthetic and more complex outcrop-based fracture networks and successfully image the significant fractures in the domain.}, language = {en} } @article{HolzBoeckerSchlierJennenSteinmetzetal.2018, author = {Holz, Nathalie E. and Boecker-Schlier, Regina and Jennen-Steinmetz, Christine and Hohm, Erika and Buchmann, Arlette F. and Blomeyer, Dorothea and Baumeister, Sarah and Plichta, Michael M. and Esser, G{\"u}nter and Schmidt, Martin and Meyer-Lindenberg, Andreas and Banaschewski, Tobias and Brandeis, Daniel and Laucht, Manfred}, title = {Early maternal care may counteract familial liability for psychopathology in the reward circuitry}, series = {Social Cognitive and Affective Neuroscience}, volume = {13}, journal = {Social Cognitive and Affective Neuroscience}, number = {11}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {1749-5016}, doi = {10.1093/scan/nsy087}, pages = {1191 -- 1201}, year = {2018}, abstract = {Reward processing is altered in various psychopathologies and has been shown to be susceptible to genetic and environmental influences. Here, we examined whether maternal care may buffer familial risk for psychiatric disorders in terms of reward processing. Functional magnetic resonance imaging during a monetary incentive delay task was acquired in participants of an epidemiological cohort study followed since birth (N = 172, 25 years). Early maternal stimulation was assessed during a standardized nursing/playing setting at the age of 3 months. Parental psychiatric disorders (familial risk) during childhood and the participants' previous psychopathology were assessed by diagnostic interview. With high familial risk, higher maternal stimulation was related to increasing activation in the caudate head, the supplementary motor area, the cingulum and the middle frontal gyrus during reward anticipation, with the opposite pattern found in individuals with no familial risk. In contrast, higher maternal stimulation was associated with decreasing caudate head activity during reward delivery and reduced levels of attention deficit hyperactivity disorder (ADHD) in the high-risk group. Decreased caudate head activity during reward anticipation and increased activity during delivery were linked to ADHD. These findings provide evidence of a long-term association of early maternal stimulation on both adult neurobiological systems of reward underlying externalizing behavior and ADHD during development.}, language = {en} } @article{DagistanliPossamaiTurneretal.2018, author = {Dagistanli, Selda and Possamai, Adam and Turner, Bryan S. and Voyce, Malcolm and Roose, Joshua}, title = {The limits of multiculturalism in Australia?}, series = {The Sociological Review}, volume = {66}, journal = {The Sociological Review}, number = {6}, publisher = {Sage Publ.}, address = {London}, issn = {0038-0261}, doi = {10.1177/0038026118768133}, pages = {1258 -- 1275}, year = {2018}, abstract = {This article focuses on the marginal extremities - the limits - of Shari'a practices in Australia, through the example of a criminal case in which four Sydney-based Muslim men whipped a Muslim convert to punish him for his excessive consumption of drugs and alcohol. The men claimed they acted in line with the doctrines of Shari'a practice to 'purify' or absolve the victim of his sins. While the case was tried before a magistrate in a lower court, it is argued in this article that its social and political significance was wider, reaching into contemporary debates around multiculturalism and immigration from non-western, non-liberal and mainly Muslim nations. Mainstream media and political narratives viewed the whipping as an example of the moral dangers of accommodating Shari'a norms, eliding the differences between peaceable Shari'a and its violent extremities, while situating the case at the limits of multicultural accommodation. This article interrogates the objectionable margins of some cultural practices through this limit case. At the same time it questions the limits or limitations of a multiculturalism that homogeneously views the practices of entire ethnic or religious groups as violent and incommensurable with dominant norms, while using these understandings as a justification for marginalising these groups.}, language = {en} } @article{TotzPetriLehmannetal.2018, author = {Totz, Sonja Juliana and Petri, Stefan and Lehmann, Jascha and Coumou, Dim}, title = {Regional Changes in the Mean Position and Variability of the Tropical Edge}, series = {Geophysical research letters}, volume = {45}, journal = {Geophysical research letters}, number = {21}, publisher = {American Geophysical Union}, address = {Washington}, issn = {0094-8276}, doi = {10.1029/2018GL079911}, pages = {12076 -- 12084}, year = {2018}, abstract = {Recent studies indicate that the tropical belt has been expanding during recent decades, which can significantly influence precipitation in subtropical climates. Often the location of the tropical border is identified using the Hadley cell edge (HCE) or the subtropical jet stream (STJ), but most studies concentrated on the zonal-mean state, thereby missing regional impacts. Here we detect longitudinal-resolved trends in STJ cores and HCEs over 1979-2016 in both hemispheres at a higher spatial and temporal resolution than previous studies. Besides pronounced regional trend differences in both sign and magnitude, we show that winter HCE and STJ variability increased in the Mediterranean region and decreased over the American and Asian continents. Rainfall variability in these regions changed likewise, and most of those changes can be explained by changes in HCE/STJ variability. This highlights the importance of understanding future tropical belt changes both regionally and in terms of variability. Plain Language Summary We applied a new network-based method to detect motion of the tropical climate border with longitudinal resolution. Depending on the longitudinal position, there are differences in both direction and magnitude of the border motion. In addition, we demonstrate that the rainfall variability is increasing in the Mediterranean region and decreasing over the American and Asian continents, which can be explained by the variability of the tropical belt location.}, language = {en} } @article{SchwanholdIobbiNivolLehmannetal.2018, author = {Schwanhold, Nadine and Iobbi-Nivol, Chantal and Lehmann, Angelika and Leimk{\"u}hler, Silke}, title = {Same but different}, series = {PLoS one}, volume = {13}, journal = {PLoS one}, number = {11}, publisher = {PLoS}, address = {San Fransisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0201935}, pages = {24}, year = {2018}, abstract = {The maturation of bacterial molybdoenzymes is a complex process leading to the insertion of the bulky bis-molybdopterin guanine dinucleotide (bis-MGD) cofactor into the apoenzyme. Most molybdoenzymes were shown to contain a specific chaperone for the insertion of the bis-MGD cofactor. Formate dehydrogenases (FDH) together with their molecular chaperone partner seem to display an exception to this specificity rule, since the chaperone FdhD has been proven to be involved in the maturation of all three FDH enzymes present in Escherichia colt. Multiple roles have been suggested for FdhD-like chaperones in the past, including the involvement in a sulfur transfer reaction from the L-cysteine desulfurase IscS to bis-MGD by the action of two cysteine residues present in a conserved CXXC motif of the chaperones. However, in this study we show by phylogenetic analyses that the CXXC motif is not conserved among FdhD-like chaperones. We compared in detail the FdhD-like homologues from Rhodobacter capsulatus and E. colt and show that their roles in the maturation of FDH enzymes from different subgroups can be exchanged. We reveal that bis-MGDbinding is a common characteristic of FdhD-like proteins and that the cofactor is bound with a sulfido-ligand at the molybdenum atom to the chaperone. Generally, we reveal that the cysteine residues in the motif CXXC of the chaperone are not essential for the production of active FDH enzymes.}, language = {en} } @article{HauptBenderFabianetal.2018, author = {Haupt, Johannes and Bender, Benedict and Fabian, Benjamin and Lessmann, Stefan}, title = {Robust identification of email tracking}, series = {European Journal of Operational Research}, volume = {271}, journal = {European Journal of Operational Research}, number = {1}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0377-2217}, doi = {10.1016/j.ejor.2018.05.018}, pages = {341 -- 356}, year = {2018}, abstract = {Email tracking allows email senders to collect fine-grained behavior and location data on email recipients, who are uniquely identifiable via their email address. Such tracking invades user privacy in that email tracking techniques gather data without user consent or awareness. Striving to increase privacy in email communication, this paper develops a detection engine to be the core of a selective tracking blocking mechanism in the form of three contributions. First, a large collection of email newsletters is analyzed to show the wide usage of tracking over different countries, industries and time. Second, we propose a set of features geared towards the identification of tracking images under real-world conditions. Novel features are devised to be computationally feasible and efficient, generalizable and resilient towards changes in tracking infrastructure. Third, we test the predictive power of these features in a benchmarking experiment using a selection of state-of-the-art classifiers to clarify the effectiveness of model-based tracking identification. We evaluate the expected accuracy of the approach on out-of-sample data, over increasing periods of time, and when faced with unknown senders. (C) 2018 Elsevier B.V. All rights reserved.}, language = {en} } @article{UtechtGaebelKlamroth2018, author = {Utecht, Manuel Martin and Gaebel, Tina and Klamroth, Tillmann}, title = {Desorption induced by low energy charge carriers on Si(111)-7 x 7}, series = {Journal of computational chemistry : organic, inorganic, physical, biological}, volume = {39}, journal = {Journal of computational chemistry : organic, inorganic, physical, biological}, number = {30}, publisher = {Wiley}, address = {Hoboken}, issn = {0192-8651}, doi = {10.1002/jcc.25607}, pages = {2517 -- 2525}, year = {2018}, abstract = {We use clusters for the modeling of local ion resonances caused by low energy charge carriers in STM-induced desorption of benzene derivates from Si(111)-7 x 7. We perform Born-Oppenheimer molecular dynamics for the charged systems assuming vertical transitions to the charged states at zero temperature, to rationalize the low temperature activation energies, which are found in experiment for chlorobenzene. Our calculations suggest very similar low temperature activation energies for toluene and benzene. For the cationic resonance transitions to physisorption are found even at 0 K, while the anion remains chemisorbed during the propagations. Further, we also extend our previous static quantum chemical investigations to toluene and benzene. In addition, an in depth analysis of the ionization potentials and electron affinities, which are used to estimate resonance energies, is given.}, language = {en} } @article{WeberScholzSchroederRitzrauetal.2018, author = {Weber, Michael and Scholz, Denis and Schr{\"o}der-Ritzrau, Andrea and Deininger, Michael and Sp{\"o}tl, Christoph and Lugli, Federico and Mertz-Kraus, Regina and Jochum, Klaus Peter and Fohlmeister, Jens Bernd and Stumpf, Cintia F. and Riechelmann, Dana F. C.}, title = {Evidence of warm and humid interstadials in central Europe during early MISSUE 3 revealed by a multi-proxy speleothem record}, series = {Quaternary science reviews : the international multidisciplinary research and review journal}, volume = {200}, journal = {Quaternary science reviews : the international multidisciplinary research and review journal}, publisher = {Elsevier}, address = {Oxford}, issn = {0277-3791}, doi = {10.1016/j.quascirev.2018.09.045}, pages = {276 -- 286}, year = {2018}, abstract = {Marine Isotope Stage 3 (MIS 3, 57-27 ka) was characterised by numerous rapid climate oscillations (i.e., Dansgaard-Oeschger (D/O-) events), which are reflected in various climate archives. So far, MIS 3 speleothem records from central Europe have mainly been restricted to caves located beneath temperate Alpine glaciers or close to the Atlantic Ocean. Thus, MIS 3 seemed to be too cold and dry to enable speleothem growth north of the Alps in central Europe. Here we present a new speleothem record from Bunker Cave, Germany, which shows two distinct growth phases from 52.0 (+0.8, -0.5) to 50.9 (+0.6, -1.3) ka and 473 (+1.0, -0.6) to 42.8 (+/- 0.9) ka, rejecting this hypothesis. These two growth phases potentially correspond to the two warmest and most humid phases in central Europe during MIS 3, which is confirmed by pollen data from the nearby Eifel. The hiatus separating the two phases is associated with Heinrich stadial 5 (HS 5), although the growth stop precedes the onset of HS 5. The first growth phase is characterised by a fast growth rate, and Mg concentrations and Sr isotope data suggest high infiltration and the presence of soil cover above the cave. The second growth phase was characterised by drier, but still favourable conditions for speleothem growth. During this phase, the delta C-13 values show a significant decrease associated with D/O-event 12. The timing of this shift is in agreement with other MIS 3 speleothem data from Europe and Greenland ice core data. (C) 2018 Elsevier Ltd. All rights reserved.}, language = {en} } @article{RamosMechieStiller2018, author = {Ramos, Catalina and Mechie, James and Stiller, Manfred}, title = {Reflection seismic images and amplitude ratio modelling of the Chilean subduction zone at 38.25 degrees S}, series = {Tectonophysics : international journal of geotectonics and the geology and physics of the interior of the earth}, volume = {747}, journal = {Tectonophysics : international journal of geotectonics and the geology and physics of the interior of the earth}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0040-1951}, doi = {10.1016/j.tecto.2018.10.007}, pages = {115 -- 127}, year = {2018}, abstract = {Active source near-vertical reflection (NVR) data from the interdisciplinary project TIPTEQ were used to image and identify structural and petrophysical properties within the Chilean subduction zone at 38.25 degrees S, where in 1960 the largest earthquake ever recorded (M-w 9.5) occurred. Reflection seismic images of the subduction zone were obtained using the post-stack depth migration technique to process the three components of the NVR data, allowing to present P- and S-stacked time sections and depth-migrated seismic reflection images. Next, the reflectivity method allowed to model traveltimes and amplitude ratios of pairs of reflections for two 1D profiles along the studied transect. The 1D seismic velocities that produced the synthetic seismograms with amplitudes and traveltimes that fit the observed ones were used to infer the rock composition of the different layers in each 1D profile. Finally, an image of the subduction zone is given. The Chilean subduction zone at 38.25 degrees S underlies a continental crust with highly reflective horizontal, as well as dipping events. Among them, the Lanalhue Fault Zone (LFZ), interpreted to be east-dipping, is imaged to very shallow depths for the first time. In terms of seismic velocities, the inferred composition of the continental crust is in agreement with field geology observations at the surface along the profile. Furthermore, no measurable amounts of fluids above the plate interface in the continental crust in this part of the Chilean subduction zone are necessary to explain the results. A large-scale anisotropy in the continental crust and upper mantle is qualitatively proposed. However, quantitative studies on this topic in the continental crust of the Chilean subduction zone at 38.25 degrees S do not exist to date.}, language = {en} } @article{RychkovAltafim2018, author = {Rychkov, Dmitry and Altafim, Ruy Alberto Pisani}, title = {Template-based fluoroethylenepropylene ferroelectrets with enhanced thermal stability of piezoelectricity}, series = {Journal of applied physics}, volume = {124}, journal = {Journal of applied physics}, number = {17}, publisher = {American Institute of Physics}, address = {Melville}, issn = {0021-8979}, doi = {10.1063/1.5041374}, pages = {5}, year = {2018}, abstract = {In ferroelectrets, the piezoelectricity stems from the charges of both polarities trapped on the inner surfaces of the cavities in the material, so that its thermal stability is defined by the stability of the respective charges. In the present work, a template-based lamination technique has been employed to fabricate tubular-channel ferroelectrets from fluoroethylenepropylene (FEP) films. It has been shown that the piezoelectricity in FEP ferroelectrets decays at relatively low temperatures due to the inherently lower thermal stability of the positive charge. In order to improve charge trapping, we have treated both FEP films and inner surfaces of the ferroelectret cavities with titanium-tetrachloride vapor, using the atomic-layer-deposition technique. Using surface-potential-decay measurements on FEP films, we have found that the charge-decay curves shift by more than 100 degrees C to the higher temperatures as a result of the surface treatment. Direct measurements of piezoelectric d(33) coefficients as a function of temperature have shown that the piezoelectric stability is likewise improved with the d(33)-decay curves shifted by 60 degrees C to the right. The improvement of electret/ferroelectret properties can be attributed to the formation of the deeper traps on the chemically modified FEP surface. SEM micrographs and EDS analysis reveal island-like structures with titanium- and oxygen-containing species that can be responsible for the deeper trapping of the electret charges. Published by AIP Publishing.}, language = {en} } @article{ReilBinderFreiseetal.2018, author = {Reil, Daniela and Binder, Florian and Freise, Jona and Imholt, Christian and Beyrers, Konrad and Jacob, Jens and Kr{\"u}ger, Detlev H. and Hofmann, J{\"o}rg and Dreesman, Johannes and Ulrich, Rainer G{\"u}nter}, title = {Hantaviren in Deutschland}, series = {Berliner und M{\"u}nchener tier{\"a}rztliche Wochenschrift}, volume = {131}, journal = {Berliner und M{\"u}nchener tier{\"a}rztliche Wochenschrift}, number = {11-12}, publisher = {Schl{\"u}tersche Verlagsgesellschaft mbH \& Co. KG.}, address = {Hannover}, issn = {0005-9366}, doi = {10.2376/0005-9366-18003}, pages = {453 -- 464}, year = {2018}, abstract = {Hantaviruses are small mammal-associated pathogens that are found in rodents but also in shrews, moles and bats. Aim of this manuscript is to give a current overview of the epidemiology and ecology of hantaviruses in Germany and to discuss respective models for the prediction of virus outbreaks. In Germany the majority of human disease cases are caused by the Puumala virus (PUUV), transmitted by the bank vole (Myodes glareolus). PUUV is associated with the Western evolutionary lineage of the bank vole and is not present in the eastern and northern parts of Germany. A second human pathogenic hantavirus is the Dobrava-Belgrade virus (DOBV), genotype Kurkino; its reservoir host, the striped field mouse (Apodemus agrarius), is mostly occurring in the eastern part of Germany. A PUUV-related hantavirus is the rarely pathogenic Tula virus (TULV), that is associated with the common vole (Microtus arvalis). In addition, Seewis virus, Asikkala virus, and Bruges virus are shrew- and mole-associated hantaviruses with still unknown pathogenicity in humans. Human disease cases are associated with the different hantaviruses according to their regional distribution. The viruses can cause mild to severe but also subclinical courses of the respective disease. The number of human PUUV disease cases in 2007, 2010, 2012, 2015 and 2017 correlates with the occurrence of high levels of seed production of beech trees ("beech mast") in the preceding year. Models based on weather parameters for the prediction of PUUV disease clusters as developed in recent years need further validation and optimisation. in addition to the abundance of infected reservoir rodents, the exposure behaviour of humans affects the risk of human infection. The application of robust forecast models can assist the public health service to develop and communicate spatially and temporally targeted information. Thus, further recommendations to mitigate infection risk for the public may be provided.}, language = {de} } @article{YalewPilzSchweitzeretal.2018, author = {Yalew, S. G. and Pilz, Tobias and Schweitzer, C. and Liersch, Stefan and van der Kwast, J. and van Griensven, A. and Mul, Marloes L. and Dickens, Chris and van der Zaag, Pieter}, title = {Coupling land-use change and hydrologic models for quantification of catchment ecosystem services}, series = {Environmental modelling \& software with environment data news}, volume = {109}, journal = {Environmental modelling \& software with environment data news}, publisher = {Elsevier}, address = {Oxford}, issn = {1364-8152}, doi = {10.1016/j.envsoft.2018.08.029}, pages = {315 -- 328}, year = {2018}, abstract = {Representation of land-use and hydrologic interactions in respective models has traditionally been problematic. The use of static land-use in most hydrologic models or that of the use of simple hydrologic proxies in land-use change models call for more integrated approaches. The objective of this study is to assess whether dynamic feedback between land-use change and hydrology can (1) improve model performances, and/or (2) produce a more realistic quantification of ecosystem services. To test this, we coupled a land-use change model and a hydrologic mode. First, the land-use change and the hydrologic models were separately developed and calibrated. Then, the two models were dynamically coupled to exchange data at yearly time-steps. The approach is applied to a catchment in South Africa. Performance of coupled models when compared to the uncoupled models were marginal, but the coupled models excelled at the quantification of catchment ecosystem services more robustly.}, language = {en} } @article{TabbenIhsanGhouletal.2018, author = {Tabben, Montassar and Ihsan, Mohammed and Ghoul, Nihel and Coquart, Jeremy and Chaouachi, Anis and Chaabene, Helmi and Tourny, Claire and Chamari, Karim}, title = {Performance 24-h After a Simulated Mixed Martial Arts Combat}, series = {Frontiers in physiology}, volume = {9}, journal = {Frontiers in physiology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-042X}, doi = {10.3389/fphys.2018.01542}, pages = {8}, year = {2018}, abstract = {Objective: The aim of the present study was to examine the effect of Cold Water Immersion (CWI) on the recovery of physical performance, hematological stress markers and perceived wellness (i.e., Hooper scores) following a simulated Mixed Martial Arts (MMA) competition. Methods: Participants completed two experimental sessions in a counter-balanced order (CWI or passive recovery for control condition: CON), after a simulated MMAs competition (3 x 5-min MMA rounds separated by 1-min of passive rest). During CWI, athletes were required to submerge their bodies, except the trunk, neck and head, in the seated position in a temperature-controlled bath (similar to 10 degrees C) for 15-min. During CON, athletes were required to be in a seated position for 15-min in same room ambient temperature. Venous blood samples (creatine kinase, cortisol, and testosterone concentrations) were collected at rest (PRE-EX, i.e., before MMAs), immediately following MMAs (POST-EX), immediately following recovery (POST-R) and 24 h post MMAs (POST-24), whilst physical fitness (squat jump, countermovement-jump and 5- and 10-m sprints) and perceptual measures (well-being Hooper index: fatigue, stress, delayed onset muscle soreness (DOMS), and sleep) were collected at PRE-EX, POST-R and POST-24, and at PRE-EX and POST-24, respectively. Conclusion: The use of CWI resulted in an enhanced recovery of 10-m sprint performance, as well as improved perceived wellness 24-h following simulated MMA competition.}, language = {en} } @article{HameisterNickels2018, author = {Hameister, Inga and Nickels, Lyndsey}, title = {The cat in the tree - using picture descriptions to inform our understanding of conceptualisation in aphasia}, series = {Language, cognition and neuroscience}, volume = {33}, journal = {Language, cognition and neuroscience}, number = {10}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {2327-3798}, doi = {10.1080/23273798.2018.1497801}, pages = {1296 -- 1314}, year = {2018}, abstract = {Conceptualisation is the first step of speech production and describes the process by which we map our thoughts onto spoken language. Recent studies suggest that some people with language impairments have conceptualisation deficits manifested by information selection and sequencing difficulties. In this study, we examined conceptualisation in the complex picture descriptions of individuals with and without aphasia. We analysed the number and the order of main concepts (ideas produced by >= 60\% of unimpaired speakers) and non-main concepts (e.g. irrelevant details). Half of the individuals with aphasia showed a reduced number of main concepts that could not be fully accounted for by their language production deficits. Moreover, individuals with aphasia produced both a larger amount of marginally relevant information, as well as having greater variability in the order of main concepts. Both findings provide support for the idea that conceptualisation deficits are a relatively common impairment in people with aphasia.}, language = {en} } @article{SiddiquiMautePedatellaetal.2018, author = {Siddiqui, Tarique Adnan and Maute, Astrid and Pedatella, Nick and Yamazaki, Yosuke and L{\"u}hr, Hermann and Stolle, Claudia}, title = {On the variability of the semidiurnal solar and lunar tides of the equatorial electrojet during sudden stratospheric warmings}, series = {Annales geophysicae}, volume = {36}, journal = {Annales geophysicae}, number = {6}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {0992-7689}, doi = {10.5194/angeo-36-1545-2018}, pages = {1545 -- 1562}, year = {2018}, abstract = {The variabilities of the semidiurnal solar and lunar tides of the equatorial electrojet (EEJ) are investigated during the 2003, 2006, 2009 and 2013 major sudden stratospheric warming (SSW) events in this study. For this purpose, ground-magnetometer recordings at the equatorial observatories in Huancayo and Fuquene are utilized. Results show a major enhancement in the amplitude of the EEJ semidiurnal lunar tide in each of the four warming events. The EEJ semidiurnal solar tidal amplitude shows an amplification prior to the onset of warmings, a reduction during the deceleration of the zonal mean zonal wind at 60 degrees N and 10 hPa, and a second enhancement a few days after the peak reversal of the zonal mean zonal wind during all four SSWs. Results also reveal that the amplitude of the EEJ semidiurnal lunar tide becomes comparable or even greater than the amplitude of the EEJ semidiurnal solar tide during all these warming events. The present study also compares the EEJ semidiurnal solar and lunar tidal changes with the variability of the migrating semidiurnal solar (SW2) and lunar (M2) tides in neutral temperature and zonal wind obtained from numerical simulations at E-region heights. A better agreement between the enhancements of the EEJ semidiurnal lunar tide and the M2 tide is found in comparison with the enhancements of the EEJ semidiurnal solar tide and the SW2 tide in both the neutral temperature and zonal wind at the E-region altitudes.}, language = {en} } @article{WernoWilhelmiKuropkaetal.2018, author = {Werno, Martin Witold and Wilhelmi, Ilka and Kuropka, Benno and Ebert, Franziska and Freund, Christian and Sch{\"u}rmann, Annette}, title = {The GTPase ARFRP1 affects lipid droplet protein composition and triglyceride release from intracellular storage of intestinal Caco-2 cells}, series = {Biochemical and biophysical research communications}, volume = {506}, journal = {Biochemical and biophysical research communications}, number = {1}, publisher = {Elsevier}, address = {San Diego}, issn = {0006-291X}, doi = {10.1016/j.bbrc.2018.10.092}, pages = {259 -- 265}, year = {2018}, abstract = {Intestinal release of dietary triglycerides via chylomicrons is the major contributor to elevated postprandial triglyceride levels. Dietary lipids can be transiently stored in cytosolic lipid droplets (LDs) located in intestinal enterocytes for later release. ADP ribosylation factor-related protein 1 (ARFRP1) participates in processes of LD growth in adipocytes and in lipidation of lipoproteins in liver and intestine. This study aims to explore the impact of ARFRP1 on LD organization and its interplay with chylomicron-mediated triglyceride release in intestinal-like Caco-2 cells. Suppression of Arfrp1 reduced release of intracellularly derived triglycerides (0.69-fold) and increased the abundance of transitional endoplasmic reticulum ATPase TERA/VCP, fatty acid synthase-associated factor 2 (FAF2) and perilipin 2 (Plin2) at the LD surface. Furthermore, TERA/VCP and FAF2 co-occurred more frequently with ATGL at LDs, suggesting a reduced adipocyte triglyceride lipase (ATGL)-mediated lipolysis. Accordingly, inhibition of lipolysis reduced lipid release from intracellular storage pools by the same magnitude as Arfrp1 depletion. Thus, the lack of Arfrp1 increases the abundance of lipolysis-modulating enzymes TERA/VCP, FAF2 and Plin2 at LDs, which might decrease lipolysis and reduce availability of fatty acids for triglyceride synthesis and their release via chylomicrons. (C) 2018 The Authors. Published by Elsevier Inc.}, language = {en} } @article{SposiniChechkinMetzler2018, author = {Sposini, Vittoria and Chechkin, Aleksei V. and Metzler, Ralf}, title = {First passage statistics for diffusing diffusivity}, series = {Journal of physics : A, Mathematical and theoretical}, volume = {52}, journal = {Journal of physics : A, Mathematical and theoretical}, number = {4}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {1751-8113}, doi = {10.1088/1751-8121/aaf6ff}, pages = {11}, year = {2018}, abstract = {A rapidly increasing number of systems is identified in which the stochastic motion of tracer particles follows the Brownian law < r(2)(t)> similar or equal to Dt yet the distribution of particle displacements is strongly non-Gaussian. A central approach to describe this effect is the diffusing diffusivity (DD) model in which the diffusion coefficient itself is a stochastic quantity, mimicking heterogeneities of the environment encountered by the tracer particle on its path. We here quantify in terms of analytical and numerical approaches the first passage behaviour of the DD model. We observe significant modifications compared to Brownian-Gaussian diffusion, in particular that the DD model may have a faster first passage dynamics. Moreover we find a universal crossover point of the survival probability independent of the initial condition.}, language = {en} }