@article{ForterreRailaForterreetal.2006, author = {Forterre, Simone and Raila, Jens and Forterre, Franck and Brunnberg, Leo and Schweigert, Florian J.}, title = {Characterisation of transthyretin and retinol-binding protein in plasma and cerebrospinal fluid of dogs}, issn = {1090-0233}, doi = {10.1016/j.tvjl.2004.11.017}, year = {2006}, abstract = {The aim of this study was to investigate differences in concentrations of vitamin A, transthyretin (TTR) and retinol-binding protein (RBP) between plasma and cerebrospinal fluid (CSF) in dogs. RBP was detected using ELISA, and both RBP and TTR by Western blot analysis after separation on SDS-PAGE. Vitamin A was determined by high performance liquid chromatography. RBP and TTR as well as vitamin A were detected in all samples but at substantially lower concentrations in CSF compared to plasma. RBP in dog plasma showed a similar molecular mass to that of humans, whereas canine TTR had a lower molecular mass. Comparison between plasma and CSF showed that both RBP and TTR were of lower molecular mass in CSF. In CSF, RBP and retinol were present at 10-100-fold lower concentrations compared to plasma. Retinyl esters were present only in minute amounts in 5/17 samples. In conclusion, the CSF of dogs compared to humans is significantly different in terms of both quality and quantity of transport proteins for vitamin A.}, language = {en} } @article{ForeterreRailaForterreetal.2004, author = {Foreterre, Simone and Raila, Jens and Forterre, Franck and Brunnberg, Leo and Schweigert, Florian J.}, title = {Characterisation of transthyretin and retinol-binding protein in plasma and cerebrospinal fluid of dogs}, year = {2004}, language = {en} }