@misc{WoodhouseMakowerYeungetal.2016, author = {Woodhouse, Jason Nicholas and Makower, A. Katharina and Yeung, Anna C. Y. and Ongley, Sarah E. and Micallef, Melinda L. and Moffitt, Michelle C. and Neilan, Brett A.}, title = {Advances in genomics, transcriptomics and proteomics of toxin-producing cyanobacteria}, series = {Environmental microbiology reports}, volume = {8}, journal = {Environmental microbiology reports}, publisher = {Wiley-Blackwell}, address = {Hoboken}, issn = {1758-2229}, doi = {10.1111/1758-2229.12366}, pages = {3 -- 13}, year = {2016}, abstract = {A common misconception persists that the genomes of toxic and non-toxic cyanobacterial strains are largely conserved with the exception of the presence or absence of the genes responsible for toxin production. Implementation of -omics era technologies has challenged this paradigm, with comparative analyses providing increased insight into the differences between strains of the same species. The implementation of genomic, transcriptomic and proteomic approaches has revealed distinct profiles between toxin-producing and non-toxic strains. Further, metagenomics and metaproteomics highlight the genomic potential and functional state of toxic bloom events over time. In this review, we highlight how these technologies have shaped our understanding of the complex relationship between these molecules, their producers and the environment at large within which they persist.}, language = {en} } @misc{PearsonDittmannMazmouzetal.2016, author = {Pearson, Leanne A. and Dittmann, Elke and Mazmouz, Rabia and Ongley, Sarah E. and Neilan, Brett A.}, title = {The genetics, biosynthesis and regulation of toxic specialized metabolites of cyanobacteria}, series = {Harmful algae}, volume = {54}, journal = {Harmful algae}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1568-9883}, doi = {10.1016/j.hal.2015.11.002}, pages = {98 -- 111}, year = {2016}, abstract = {The production of toxic metabolites by cyanobacterial blooms represents a significant threat to the health of humans and ecosystems worldwide. Here we summarize the current state of the knowledge regarding the genetics, biosynthesis and regulation of well-characterized cyanotoxins, including the microcystins, nodularin, cylindrospermopsin, saxitoxins and antitoxins, as well as the lesser-known marine toxins (e.g. lyngbyatoxin, aplysiatoxin, jamaicamides, barbamide, curacin, hectochlorin and apratoxins). (C) 2015 Elsevier B.V. All rights reserved.}, language = {en} }